Stem cell gel stirring device

Abstract

The utility model provides a kind of stem cell gel stirring device, it is related to stem cell field.The stem cell gel stirring device, including stirring bucket, the top of stirring bucket is equipped with with the feeding hole being connected with stirring bucket inside, the right side of stirring bucket is fixedly connected with fixed frame, the right end of fixed frame is fixedly connected with driving mechanism, the output of driving mechanism is fixedly connected with agitating rod, the lower surface of agitating rod is fixedly connected with mixing frame.The stem cell gel stirring device, through the cooperation between sealing plate, screw rod, first fixed block, second fixed block, rubber pad, jackscrew, support shaft, rotary cylinder, movable plate, bracing piece and backing plate, it can be inclined to stirring device, stem cell gel is mixed and poured out after completion, increase discharge efficiency, solve the problem that stem cell gel stirring device mixes and works, stem cell gel is discharged in process, prone to outlet blockage, affect stem cell gel discharge.

Description

Technical Field

[0001] This utility model relates to the field of stem cell technology, specifically a stem cell gel stirring device. Background Technology

[0002] Hydrogels are a class of polymers with hydrophilic groups that swell in water but are insoluble in water, possessing a three-dimensional network structure. Some hydrogels are insoluble in water and can sense minute external stimuli (intelligent hydrogels). Researchers have discovered that, in addition to their moisture-absorbing properties, hydrogels can also be used in transdermal drug delivery systems (or dressings), as adjuvants for stem cell therapy, and as dissolvable adhesive bandages, among other applications.

[0003] Hydrogels used to culture stem cells contain biomolecules that promote stem cell self-renewal and differentiation, mimicking the natural environment of stem cells by providing them with a protein- and sugar-rich extracellular matrix (ECM). Stem cells adhere to the ECM and spontaneously organize into miniature organs, such as the retina, kidney, or intestine. Biomaterials provide stem cells with a growth microenvironment; when stem cells encounter biomaterials, many challenges in regenerative medicine become miraculous. Stem cells combined with hydrogels can repair insomnia and brain damage. Researchers at the University of Toronto in Canada have developed a hydrogel biomaterial that helps maintain cell viability and allows them to better bind into tissues. Two early trials showed that this material can, to some extent, reverse blindness and help stroke patients recover. The related paper was published in Stem Cell Reports.

[0004] Researchers are developing new therapies for nerve damage caused by disease or trauma. They transplanted stem cells into the eyes and brains of mice after encapsulating them in a hydrogel and found it promoted the recovery of damaged function. The hydrogel consists of two components—methylcellulose and hyaluronic acid (the former forms a gel and binds cells together, while the latter helps cells survive).

[0005] Stem cells hold great promise in regenerative medicine, with the potential to cultivate replacement tissues and organs. While culturing stem cells in the lab is relatively easy, transplanting them to where the body needs them presents numerous challenges. The body's environment is extremely complex, and transplanted stem cells often die or fail to integrate well into surrounding tissues. Hydrogels, initially used simply as bubble-like encapsulations to bind cells together during transfer and implantation, can now not only bind cells together but also directly promote stem cell survival and aggregation, bringing stem cell therapy closer to reality.

[0006] Researchers cultured photoreceptors from stem cells, encapsulated them in a hydrogel, and injected them into the eyes of blind mice. As more and more cells survived and grew together, the mice regained some vision. Tests showed that pupillary reflexes recovered by about 15%, and the eyes began to detect light and respond. In another study, researchers injected stem cells into the brains of mice that had recently suffered a stroke. Several weeks later, the mice's motor coordination began to improve. Researchers noted that the hydrogel's ability to promote cell survival in the eyes and brain could potentially be used for cell transplantation in other parts of the body. Another advantage of the hydrogel is that once the cells are delivered to the designated location, they degrade and are absorbed by the body within a few weeks.

[0007] Stem cell gels require mixing stem cells and hydrogels to obtain the product. Currently, stem cell gel mixing devices are prone to outlet blockage during the discharge of stem cell gels, which affects the discharge of the gels. Utility Model Content

[0008] The purpose of this invention is to provide a stem cell gel stirring device that solves the problem that current stem cell gel stirring devices often experience outlet blockage during the discharge of stem cell gel after mixing, thus affecting the discharge of stem cell gel.

[0009] Technical solution

[0010] To achieve the above objectives, this utility model provides the following technical solution: a stem cell gel stirring device, comprising a stirring tank, a feeding hole communicating with the interior of the stirring tank at the top, a fixing frame fixedly connected to the right side of the stirring tank, a driving mechanism fixedly connected to the right end of the fixing frame, a stirring rod fixedly connected to the output end of the driving mechanism, a mixing frame fixedly connected to the lower surface of the stirring rod, a scraper fixedly connected to the bottom end of the mixing frame, a sealing plate overlapping the left side of the stirring tank, a first fixing block fixedly connected to the top of the sealing plate, a second fixing block fixedly connected to the top of the stirring tank, and a screw threaded between the first fixing block and the second fixing block. A movable plate is fixedly connected to the bottom of the mixing tank, and a rotating cylinder is fixedly connected to the front of the movable plate. A support shaft is movably connected inside the rotating cylinder, and a support rod is fixedly connected to the lower surface of the support shaft. A pad is fixedly connected to the bottom end of the support rod, and a top rod is fixedly connected to the upper surface of the pad. Stem cells and hydrogel are poured into the mixing tank through the feeding hole, and the drive mechanism is started to stir them. After stirring, the screw is unscrewed, the sealing plate is removed from the left side of the mixing tank, and the right side of the mixing tank is lifted upwards. This causes the mixing tank to rotate on the surface of the support shaft via the movable plate, tilting the entire mixing tank to the left and pouring the stem cell gel inside the mixing tank outwards, increasing the discharge efficiency.

[0011] Furthermore, a rubber pad is fixedly connected to the top of the top rod, and the upper surface of the rubber pad overlaps with the bottom of the mixing tank.

[0012] Furthermore, the lower surface of the scraper overlaps with the inner bottom wall of the mixing tank.

[0013] Furthermore, the right side of the first fixing block overlaps with the left side of the second fixing block.

[0014] Furthermore, there are two fixing frames, which are symmetrically arranged about the central axis of the mixing tank.

[0015] This invention provides a stem cell gel stirring device. It has the following beneficial effects:

[0016] This stem cell gel stirring device, through the cooperation of a sealing plate, screw, first fixed block, second fixed block, rubber pad, top rod, support shaft, rotating cylinder, movable plate, support rod, and pad, allows the stirring device to be tilted, so that the stem cell gel can be poured out after mixing, increasing the discharge efficiency. This solves the problem that current stem cell gel stirring devices are prone to outlet blockage during the discharge of stem cell gel after mixing, which affects the discharge of stem cell gel. Attached Figure Description

[0017] Figure 1 This is a schematic diagram of the structure of this utility model;

[0018] Figure 2 This is a front view of the structure of this utility model.

[0019] The components include: 1. mixing tank; 2. feeding hole; 3. fixed frame; 4. drive mechanism; 5. stirring rod; 6. mixing frame; 7. scraper; 8. sealing plate; 9. screw; 10. first fixed block; 11. second fixed block; 12. rubber pad; 13. top rod; 14. support shaft; 15. rotating cylinder; 16. movable plate; 17. support rod; and 18. pad plate. Detailed Implementation

[0020] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present utility model. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments.

[0021] Examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and intended to explain the present invention, and should not be construed as limiting the present invention.

[0022] In the description of this utility model, it should be understood that the terms "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential", etc., indicating the orientation or positional relationship are based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing this utility model and simplifying the description, and are not intended to indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model.

[0023] In this utility model, unless otherwise explicitly specified and limited, the terms "installation," "connection," "joining," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0024] like Figures 1-2 As shown, this embodiment of the present invention provides a stem cell gel stirring device, including a stirring tank 1. A feeding hole 2, communicating with the interior of the stirring tank 1, is opened at the top of the stirring tank 1. Two fixing frames 3 are fixedly connected to the right side of the stirring tank 1, symmetrically arranged about the central axis of the stirring tank 1. A driving mechanism 4 is fixedly connected to the right end of the fixing frame 3. A stirring rod 5 is fixedly connected to the output end of the driving mechanism 4. A mixing frame 6 is fixedly connected to the lower surface of the stirring rod 5. A scraper 7 is fixedly connected to the bottom end of the mixing frame 6, and the lower surface of the scraper 7 overlaps with the inner bottom wall of the stirring tank 1. A sealing plate 8 overlaps on the left side of the stirring tank 1, and a first fixing device is fixedly connected to the top of the sealing plate 8. A first fixed block 10 is fixedly connected to the top of the mixing tank 1, and a second fixed block 11 is fixedly connected to the top of the mixing tank 1. The right side of the first fixed block 10 overlaps with the left side of the second fixed block 11. A screw 9 is threadedly connected between the first fixed block 10 and the second fixed block 11. A movable plate 16 is fixedly connected to the bottom of the mixing tank 1. A rotating cylinder 15 is fixedly connected to the front of the movable plate 16. A support shaft 14 is movably connected inside the rotating cylinder 15. A support rod 17 is fixedly connected to the lower surface of the support shaft 14. A pad 18 is fixedly connected to the bottom of the support rod 17. A top rod 13 is fixedly connected to the upper surface of the pad 18. A rubber pad 12 is fixedly connected to the top of the top rod 13. The upper surface of the rubber pad 12 overlaps with the bottom of the mixing tank 1.

[0025] Working principle: Stem cells and hydrogel are poured into the interior of the mixing tank 1 through the feeding hole 2. The drive mechanism 4 is started to stir them. After stirring, the screw 9 is unscrewed, the sealing plate 8 is removed from the left side of the mixing tank 1, and the right side of the mixing tank 1 is lifted upward. This causes the mixing tank 1 to rotate on the surface of the support shaft 14 via the movable plate 16, causing the mixing tank 1 to tilt to the left and pour the stem cell gel inside the mixing tank 1 outward, increasing the discharge efficiency.

[0026] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A stem cell gel stirring device comprising a stirring barrel (1), characterized in that: The top of the mixing tank (1) has a feeding hole (2) that communicates with the inside of the mixing tank (1). A fixing frame (3) is fixedly connected to the right side of the mixing tank (1). A driving mechanism (4) is fixedly connected to the right end of the fixing frame (3). A stirring rod (5) is fixedly connected to the output end of the driving mechanism (4). A mixing frame (6) is fixedly connected to the lower surface of the stirring rod (5). A scraper (7) is fixedly connected to the bottom end of the mixing frame (6). A sealing plate (8) overlaps on the left side of the mixing tank (1). A first fixing block (10) is fixedly connected to the top of the sealing plate (8). A second fixing block (11) is fixedly connected to the top of the bucket (1). A screw (9) is threaded between the first fixing block (10) and the second fixing block (11). A movable plate (16) is fixedly connected to the bottom of the mixing bucket (1). A rotating cylinder (15) is fixedly connected to the front of the movable plate (16). A support shaft (14) is movably connected inside the rotating cylinder (15). A support rod (17) is fixedly connected to the lower surface of the support shaft (14). A pad (18) is fixedly connected to the bottom end of the support rod (17). A top rod (13) is fixedly connected to the upper surface of the pad (18).

2. The stem cell gel stirring device of claim 1, wherein: A rubber pad (12) is fixedly connected to the top of the top rod (13), and the upper surface of the rubber pad (12) overlaps with the bottom of the mixing tank (1).

3. The stem cell gel stirring device of claim 1, wherein: The lower surface of the scraper (7) overlaps with the inner bottom wall of the mixing tank (1).

4. The stem cell gel stirring device of claim 1, wherein: The right side of the first fixing block (10) overlaps with the left side of the second fixing block (11).

5. The stem cell gel stirring device of claim 1, wherein: The number of the fixing frames (3) is two, and the two fixing frames (3) are symmetrically arranged about the central axis of the mixing tank (1).

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