Polypeptide medicine constant-temperature synthesis kettle

Abstract

This utility model provides a constant temperature synthesis vessel for polypeptide drugs, comprising: a synthesis vessel, which includes a lower connecting ring seat, a first sealing ring groove, and a second sealing ring groove. The first sealing ring groove is formed on the upper surface of the lower connecting ring seat. Compared with the prior art, this utility model has the following beneficial effects: by adding a synthesis vessel, a synthesis mixing component, a heat preservation component, a second sealing ring, and a sealing strip, the two sets of heat preservation components are installed symmetrically above the lower connecting ring seat. The heat generated by the motor in the synthesis mixing component is conducted to the main heat preservation pipe through a waste heat conduction fan, and then distributed to the second heat preservation chamber of the two sets of heat preservation components through two sets of waste heat distribution pipes, thereby realizing the heat preservation and utilization of waste heat. The first heat preservation chamber is heated by an electric heating tube to achieve heat preservation, and the vacuum structure of the third heat preservation chamber assists in heat preservation, which can increase the constant temperature synthesis control effect. By adding a synthesis vessel, a synthesis mixing component, and a heat preservation component, it is easy to disassemble and use independently.

Description

Technical Field

[0001] This invention belongs to the field of preparation technology of oral preparations of smegglutide, and specifically relates to a constant temperature synthesis vessel for polypeptide drugs. Background Technology

[0002] Smegglutide oral formulation is a novel hypoglycemic drug based on a GLP-1 receptor agonist. It is used to treat type 2 diabetes and obesity-related diseases in adults by delaying gastric emptying, suppressing appetite, and promoting insulin secretion. The preparation of smegglutide oral formulation requires the reaction and mixing of multiple raw materials in a synthesis reactor. However, solid-phase synthesis of peptides is temperature-sensitive; temperature fluctuations can lead to side reactions (such as racemization and peptide deletion), affecting purity and yield. Therefore, isothermal synthesis is necessary for peptide drugs (smegglutide oral formulation), requiring a synthesis reactor with an insulating structure. Commonly used synthesis reactors for peptide drugs only have a single insulating structure, such as adding insulating cotton for temperature control. This structure has poor insulation performance, resulting in significant heat loss and making temperature control difficult. Furthermore, the motor used for mixing and agitation in the synthesis reactor generates considerable heat, which is often directly dissipated to the outside environment without being utilized.

[0003] In summary, we hope to propose a new structure to solve the aforementioned technical problems. Utility Model Content

[0004] In view of the shortcomings of the existing technology, the purpose of this utility model is to provide a constant temperature synthesis vessel for polypeptide drugs, so as to solve the problems mentioned in the background technology.

[0005] This utility model is achieved through the following technical solution: a constant temperature synthesis vessel for polypeptide drugs, comprising: a synthesis vessel, wherein the synthesis vessel includes a lower connecting ring seat, a first sealing ring groove, and a second sealing ring groove. The upper surface of the lower connecting ring seat has the first sealing ring groove, and the lower surface of the lower connecting ring seat has the second sealing ring groove. Two sets of symmetrically arranged heat preservation components are installed below the lower connecting ring seat. A synthesis mixing component is installed above the lower connecting ring seat. The synthesis mixing component includes a motor cover, a waste heat guide fan, a waste heat main pipe, and a waste heat branch pipe. A waste heat guide fan for recovering and utilizing the heat generated by the motor is installed on the inner side of the upper end of the motor cover. A waste heat main pipe is fixedly connected above the motor cover. Two sets of waste heat branch pipes are fixedly connected to the other end of the waste heat main pipe. The heat preservation component includes a first heat preservation cavity, a second heat preservation cavity, and a third heat preservation cavity. A sealing strip is installed between the two sets of heat preservation components. A second sealing ring is installed between the heat preservation component and the lower connecting ring seat.

[0006] In a preferred embodiment, a synthesis reactor body is fixedly connected below the lower connecting ring seat, a reactor upper cover is fixedly connected below the motor cover, an upper connecting ring seat is fixedly connected to the outer side of the lower end of the reactor upper cover, and an internal temperature sensor is installed inside the synthesis reactor body.

[0007] In a preferred embodiment, a sealing ring is fixedly connected to the lower surface of the upper connecting ring seat, and the sealing ring and the sealing ring groove are mutually sealed and fitted together. A motor is fixedly installed inside the motor cover, and a vacuum insulation cavity is opened inside the upper cover of the reactor. After the synthesis and mixing components are installed, the sealing ring and the sealing ring groove are fitted together to form a sealing structure to reduce heat loss.

[0008] In a preferred embodiment, the heat insulation component further includes a heat insulation ring seat, and a residual heat communication pipe is fixedly connected to the rear side of the heat insulation ring seat.

[0009] In a preferred embodiment, a first insulation cavity is formed on the inner side of the insulation ring seat. The inner side of the first insulation cavity is filled with insulation liquid and is provided with several sets of electric heating tubes. A temperature sensor for monitoring the temperature inside the cavity is also installed inside the first insulation cavity (the temperature sensor inside the vessel and the temperature sensor are selected as high-precision temperature sensors. The specific model can be selected from existing mature equipment on the market, as long as it meets the use of this utility model. The related connection circuits and control methods all use existing technologies and will not be described in detail here).

[0010] In a preferred embodiment, the second insulation cavity is located outside the first insulation cavity and is connected to the waste heat communication pipe. The third insulation cavity is located outside the second insulation cavity and is in a vacuum state. Foam cotton is filled between the third insulation cavity and the second insulation cavity. The heat generated by the motor is conducted through the waste heat main pipe and introduced into the second insulation cavity of the two sets of insulation components through two sets of waste heat branch pipes. A multi-layer insulation structure is formed by the first insulation cavity, the second insulation cavity, the third insulation cavity and the foam cotton.

[0011] In a preferred embodiment, a set of mating plates are fixedly connected to both the left and right ends of the heat insulation ring seat. A sealing groove is provided on the outer side of the mating plate. The sealing strip and the sealing groove are mutually sealed and fitted together. The second sealing ring and the second sealing ring groove are mutually sealed and fitted together.

[0012] In a preferred embodiment, the upper connecting ring seat and the lower connecting ring seat are attached to each other and fixed by bolts. The mating plates of the two sets of heat preservation components are also attached to each other and fixed by bolts. Each of the lower ends of the two sets of waste heat distribution pipes is provided with a quick connector for quick connection. The waste heat connecting pipe is connected to the quick connector. The synthesis mixing component is installed through the connection of the upper connecting ring seat and the lower connecting ring seat. The heat preservation components are symmetrically installed on the outside of the synthesis kettle body on both sides, and the waste heat distribution pipe is connected to the waste heat connecting pipe through the quick connector, so as to facilitate independent disassembly and assembly.

[0013] After adopting the above technical solution, the beneficial effects of this utility model are:

[0014] 1. By adding a synthesis reactor, a synthesis mixing component, a heat preservation component, a second sealing ring, and a sealing strip, two sets of heat preservation components are installed symmetrically above the lower connecting ring seat. The heat generated by the motor in the synthesis mixing component is conducted to the main heat preservation pipe via a waste heat conduction fan, and then distributed to the second heat preservation chamber of the two sets of heat preservation components via two sets of waste heat distribution pipes, realizing the heat preservation and utilization of waste heat. The first heat preservation chamber is heated by an electric heating tube to achieve heat preservation, and the vacuum structure of the third heat preservation chamber assists in heat preservation. In addition, the synthesis mixing component is assisted in heat preservation by the vacuum heat preservation chamber during use, thereby increasing the constant temperature synthesis control effect.

[0015] 2. By adding a synthesis reactor, a synthesis mixing component, and a heat preservation component, the synthesis mixing component is installed by connecting the upper and lower connecting ring seats. The heat preservation components are symmetrically installed on the outside of the synthesis reactor body in two sets, and the waste heat distribution pipe is connected to the waste heat connecting pipe via a quick connector, which makes it easy to disassemble and use independently. Attached Figure Description

[0016] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0017] Figure 1 This is a schematic diagram of the overall structure of a constant-temperature synthesis vessel for polypeptide drugs according to this utility model.

[0018] Figure 2 This is a schematic diagram of the exploded structure of a isothermal synthesis reactor for polypeptide drugs according to this utility model.

[0019] Figure 3 This is a schematic diagram of the upper structure of the synthesis vessel in the isothermal synthesis vessel for polypeptide drugs according to this utility model.

[0020] Figure 4This is a schematic diagram of the lower structure of the synthesis vessel in the isothermal synthesis vessel for polypeptide drugs according to this utility model.

[0021] Figure 5 This is a schematic diagram of the synthesis and mixing components in a constant-temperature synthesis reactor for polypeptide drugs according to this utility model.

[0022] Figure 6 This is a partial cross-sectional schematic diagram of the synthesis and mixing components in a constant-temperature synthesis reactor for polypeptide drugs according to this utility model.

[0023] Figure 7 This is a schematic diagram of the heat preservation component in a constant-temperature synthesis reactor for polypeptide drugs according to this utility model.

[0024] Figure 8 This is a partial cross-sectional schematic diagram of the heat preservation component in a constant-temperature synthesis reactor for polypeptide drugs according to this utility model.

[0025] In the figure, 100-synthesis reactor, 101-synthesis reactor body, 102-lower connecting ring seat, 103-sealing ring groove one, 104-sealing ring groove two;

[0026] 200-Synthesis mixing component, 201-Upper lid of the reactor, 202-Upper connecting ring seat, 203-Sealing ring one, 204-Vacuum insulation cavity, 205-Motor cover, 206-Waste heat conduction fan, 207-Waste heat main pipe, 208-Waste heat branch pipe, 209-Quick connector;

[0027] 300-Insulation component, 301-Insulation ring seat, 302-Butt plate, 303-Sealing groove, 304-Residual heat connecting pipe, 305-First insulation cavity, 306-Heating tube, 307-Second insulation cavity, 308-Third insulation cavity;

[0028] 400-Sealing Ring Two;

[0029] 500 - Sealing strip. Detailed Implementation

[0030] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0031] Please see Figures 1-8 As the first embodiment of this utility model:

[0032] A constant temperature synthesis vessel for polypeptide drugs includes: a synthesis vessel 100, wherein the synthesis vessel 100 includes a lower connecting ring seat 102, a first sealing ring groove 103 and a second sealing ring groove 104, and the first sealing ring groove 103 is provided on the upper surface of the lower connecting ring seat 102.

[0033] A sealing ring groove 104 is provided on the lower surface of the lower connecting ring seat 102. Two sets of symmetrically arranged heat preservation components 300 are installed below the lower connecting ring seat 102. A synthesis and mixing component 200 is installed above the lower connecting ring seat 102. The synthesis and mixing component 200 includes a motor cover 205, a waste heat conduction fan 206, a waste heat main pipe 207, and a waste heat branch pipe 208.

[0034] A waste heat guide fan 206 for recovering and utilizing the heat generated by the motor is installed on the inner side of the upper end of the motor cover 205. A waste heat main pipe 207 is fixedly connected to the upper part of the motor cover 205. Two sets of waste heat branch pipes 208 are fixedly connected to the other end of the waste heat main pipe 207. The heat insulation component 300 includes a first heat insulation cavity 305, a second heat insulation cavity 307 and a third heat insulation cavity 308. A sealing strip 500 is installed between the two sets of heat insulation components 300. A sealing ring 400 is installed between the heat insulation component 300 and the lower connecting ring seat 102.

[0035] The lower connecting ring seat 102 is fixedly connected to the synthesis reactor body 101 below, the upper cover 201 is fixedly connected to the lower part of the motor cover 205, the upper connecting ring seat 202 is fixedly connected to the outer side of the lower end of the upper cover 201, and the reactor body 101 is equipped with an internal temperature sensor.

[0036] A sealing ring 203 is fixedly connected to the lower surface of the upper connecting ring seat 202. The sealing ring 203 and the sealing ring groove 103 are mutually sealed and fitted. A motor is fixedly installed inside the motor cover 205. A vacuum insulation cavity 204 is opened inside the upper cover 201 of the reactor. After the synthesis mixing component 200 is installed, the sealing ring 203 and the sealing ring groove 103 are fitted to form a sealing structure to reduce heat loss.

[0037] The insulation component 300 also includes an insulation ring seat 301, and a residual heat connecting pipe 304 is fixedly connected to the rear side of the insulation ring seat 301.

[0038] The inner circumference of the heat-insulating ring seat 301 is provided with a first heat-insulating cavity 305. The inner side of the first heat-insulating cavity 305 is filled with heat-insulating liquid and is provided with several sets of electric heating tubes 306. A temperature sensor for monitoring the temperature inside the cavity is also installed inside the first heat-insulating cavity 305 (the temperature sensor inside the vessel and the temperature sensor are selected as high-precision temperature sensors. The specific model can be selected from existing mature equipment on the market, as long as it meets the use of this utility model. The related connection circuits and control methods all use existing technologies and will not be described in detail here).

[0039] The second insulation cavity 307 is located outside the first insulation cavity 305 and is connected to the waste heat connecting pipe 304. The third insulation cavity 308 is located outside the second insulation cavity 307 and is in a vacuum state. Foam cotton is filled between the third insulation cavity 308 and the second insulation cavity 307. The heat generated by the motor is conducted through the waste heat main pipe 207 and introduced into the second insulation cavity 307 of the two sets of insulation components 300 through the two sets of waste heat branch pipes 208. The first insulation cavity 305, the second insulation cavity 307, the third insulation cavity 308 and the foam cotton form a multi-layer insulation structure.

[0040] A set of mating plates 302 are fixedly connected to both ends of the insulation ring seat 301. A sealing groove 303 is opened on the outer side of the mating plate 302. The sealing strip 500 and the sealing groove 303 are mutually sealed and fitted together. The sealing ring 400 and the sealing ring groove 104 are mutually sealed and fitted together.

[0041] Specifically, two sets of heat insulation components 300 are symmetrically installed on the outside of the synthesis reactor body 101, and the synthesis mixing component 200 is installed above the lower connecting ring seat 102. After the synthesis mixing component 200 is installed, the sealing ring 203 and the sealing ring groove 103 are fitted together to form a sealing structure to reduce heat loss. After the two sets of heat insulation components 300 are installed, the sealing ring 400 and the sealing ring groove 104 are fitted together to form a sealing structure to reduce heat loss. The high-power operation of the motor in the synthesis mixing component 200 will generate a lot of heat, which will be collected inside the motor cover 205. Then, it will be guided to the waste heat main pipe 207 through the waste heat guide fan 206, and then introduced into the second heat insulation cavity 307 of the two sets of heat insulation components 300 through the two sets of waste heat branch pipes 208, so as to use the waste heat for auxiliary heat insulation.

[0042] Secondly, the insulation liquid in the first insulation cavity 305 can be heated by the electric heating tube 306 and the temperature can be detected by the temperature sensor. The third insulation cavity 308 is in a vacuum state. The first insulation cavity 305, the second insulation cavity 307, the third insulation cavity 308 and the foam cotton form a multi-layer insulation structure, thereby increasing the constant temperature synthesis control effect.

[0043] Please see Figures 1-5 and Figure 7 As a second embodiment of this utility model:

[0044] The upper connecting ring seat 202 and the lower connecting ring seat 102 are attached to each other and fixed with bolts. The mating plates 302 of the two sets of heat preservation components 300 are also attached to each other and fixed with bolts. Each of the lower ends of the two sets of waste heat distribution pipes 208 is provided with a quick connector 209 for quick connection. The waste heat connecting pipe 304 is connected to the quick connector 209. The synthesis mixing component 200 and the heat preservation component 300 are both detachable structures that are installed with the synthesis kettle 100, and the waste heat distribution pipe 208 and the waste heat connecting pipe 304 are connected via the quick connector 209.

[0045] Based on the first embodiment described above, the synthesis mixing component 200 is further fixed by placing the upper connecting ring seat 202 above the lower connecting ring seat 102 and then connecting it with bolts. The heat preservation component 300 is installed symmetrically in two sets on the outside of the synthesis vessel body 101 and is fixed by bolts after being attached to the mating plate 302. It is also fixed with bolts between itself and the lower connecting ring seat 102. This makes both the synthesis mixing component 200 and the heat preservation component 300 detachable structures for installation with the synthesis vessel 100. Furthermore, the waste heat distribution pipe 208 is connected to the waste heat connecting pipe 304 via the quick connector 209, which completes the convenient connection of the waste heat utilization pipeline, thereby facilitating independent disassembly and assembly.

[0046] The above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A polypeptide drug thermostatted synthesis kettle comprising: A synthesis reactor (100) is characterized in that: the synthesis reactor (100) includes a lower connecting ring seat (102), a first sealing ring groove (103) and a second sealing ring groove (104), and the upper surface of the lower connecting ring seat (102) is provided with the first sealing ring groove (103); The lower connecting ring seat (102) has a sealing ring groove (104) on its lower surface. Two sets of symmetrically arranged heat preservation components (300) are installed below the lower connecting ring seat (102). A synthetic mixing component (200) is installed above the lower connecting ring seat (102). The synthetic mixing component (200) includes a motor cover (205), a waste heat guide fan (206), a waste heat main pipe (207), and a waste heat branch pipe (208). The upper inner side of the motor cover (205) is equipped with a waste heat guide fan (206) for recovering and utilizing the heat generated by the motor. A waste heat main pipe (207) is fixedly connected above the motor cover (205). Two sets of waste heat branch pipes (208) are fixedly connected to the other end of the waste heat main pipe (207). The heat insulation component (300) includes a first heat insulation cavity (305), a second heat insulation cavity (307) and a third heat insulation cavity (308). A sealing strip (500) is installed between the two sets of heat insulation components (300). A sealing ring two (400) is installed between the heat insulation component (300) and the lower connecting ring seat (102).

2. The polypeptide pharmaceutical thermostated synthesis vessel of claim 1, wherein: The lower connecting ring seat (102) is fixedly connected to the synthesis reactor body (101), the lower motor cover (205) is fixedly connected to the reactor top cover (201), the lower outer side of the reactor top cover (201) is fixedly connected to the upper connecting ring seat (202), and the reactor body (101) is equipped with an internal temperature sensor.

3. The isothermal synthesis reactor for polypeptide drugs as described in claim 2, characterized in that: A sealing ring (203) is fixedly connected to the lower surface of the upper connecting ring seat (202). The sealing ring (203) and the sealing ring groove (103) are mutually sealed and fitted. A motor is fixedly installed inside the motor cover (205). A vacuum insulation cavity (204) is opened inside the upper cover (201).

4. The constant-temperature synthesis reactor for polypeptide drugs according to claim 2, characterized in that: The insulation component (300) also includes an insulation ring seat (301), and a residual heat connecting pipe (304) is fixedly connected to the rear side of the insulation ring seat (301).

5. The polypeptide pharmaceutical thermostated synthesis vessel of claim 4, wherein: The inner circumference of the heat-insulating ring seat (301) is provided with a first heat-insulating cavity (305). The inner side of the first heat-insulating cavity (305) is filled with heat-insulating liquid and is provided with several sets of electric heating tubes (306). A temperature sensor for monitoring the temperature inside the cavity is also installed inside the first heat-insulating cavity (305).

6. The isothermal synthesis reactor for polypeptide drugs as described in claim 5, characterized in that: The second heat preservation cavity (307) is located outside the first heat preservation cavity (305) and is connected to the waste heat connecting pipe (304). The third heat preservation cavity (308) is located outside the second heat preservation cavity (307) and is in a vacuum state. Foam cotton is filled between the third heat preservation cavity (308) and the second heat preservation cavity (307).

7. The constant-temperature synthesis reactor for polypeptide drugs according to claim 4, characterized in that: The insulation ring seat (301) is fixedly connected to a set of docking plates (302) at both ends. The outer side of the docking plate (302) is provided with a sealing groove (303). The sealing strip (500) and the sealing groove (303) are mutually sealed and fitted together. The sealing ring two (400) and the sealing ring groove two (104) are mutually sealed and fitted together.

8. The constant-temperature synthesis reactor for polypeptide drugs according to claim 4, characterized in that: The upper connecting ring seat (202) and the lower connecting ring seat (102) are attached to each other and fixed by bolts. The mating plates (302) of the two sets of heat insulation components (300) are also attached to each other and fixed by bolts. The lower end of the two sets of waste heat distribution pipes (208) is provided with a quick connector (209) for quick connection. The waste heat connecting pipe (304) is connected to the quick connector (209).

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