A modular separation component and biopharmaceutical purification equipment

Abstract

A modular separation component and biopharmaceutical purification equipment, belonging to the field of biopharmaceutical separation technology, solves the problem of poor connection stability between the drum and drive rod in sedimentation centrifuges. The modular separation component includes a base plate, with a drive rod rotatably mounted at the top center of the base plate. A drum is detachably mounted on the drive rod. Symmetrically arranged protrusions on the drive rod engage with slots inside the drum's insertion holes. A ring is fitted at the top of the drive rod, connected to the inner wall of the drum by fastening bolts and secured with a nut. The biopharmaceutical purification equipment includes the above component and a hollow sealed chamber. A U-shaped skimming tube is located on the top of the chamber cover, driven by an electric push rod for lateral movement. An observation tube with a transparent sheet and scraper is also provided. This equipment improves the connection stability between the drum and drive rod, facilitates drum disassembly, and allows for easy observation of the processing status.

Description

Technical Field

[0001] This utility model relates to the field of biomedical separation technology, and in particular to a modular separation component and biomedical purification equipment. Background Technology

[0002] Biopharmaceutical purification equipment plays a crucial role in drug research, development, production, and clinical applications. Its core function is to remove impurities through physical, chemical, or biological means to improve the purity, activity, and safety of the target product. Centrifuges, as the core equipment for separating mixtures, can be divided into two categories based on their separation principle: filtration centrifuges and sedimentation centrifuges. In sedimentation centrifuges, those with skimming tubes utilize centrifugal force generated by the rotation of the drum to cause solid particles in the suspension to settle onto the drum wall, forming sediment. The clarified liquid is then discharged through the skimming tube. However, in existing sedimentation centrifuges, the drum and drive rod are often connected by nuts. This connection method suffers from poor stability during operation, potentially affecting separation efficiency and equipment lifespan.

[0003] To address the aforementioned problems, this utility model proposes a modular separation component and a biopharmaceutical purification device. Utility Model Content

[0004] This invention provides a modular separation component and a biopharmaceutical purification device, which solves the problem that in the prior art, the drum and transmission rod of a sedimentation centrifuge are mostly connected by nuts. This connection method has poor stability during equipment operation and may affect the separation effect and equipment life.

[0005] This utility model provides the following technical solution:

[0006] A modular, separable component, comprising:

[0007] A base plate, wherein a transmission rod is rotatably mounted on the center of the top of the base plate via a bearing, and a rotating drum is detachably mounted on the transmission rod. The center of the rotating drum has an insertion hole for the transmission rod to pass through, and a ring is fitted on the transmission rod. The bottom of the ring is tightly abutted against the center of the inner wall of the rotating drum, and the top of the transmission rod passes through the through hole in the center of the ring and is connected to a matching nut via an external thread at the top.

[0008] A drive motor for driving the transmission rod to rotate is fixedly installed at the center of the bottom of the substrate. The output shaft of the drive motor passes through the top of the substrate and is fixedly connected to the bottom end of the transmission rod.

[0009] In one possible design, two protrusions are symmetrically fixed on the transmission rod to prevent the drum from slipping, and the inner wall of the insertion hole is provided with a slot for inserting the corresponding protrusion.

[0010] In one possible design, each of the two through holes on the ring is provided with a corresponding fastening bolt, and the end of the fastening bolt is threadedly connected to the corresponding threaded groove on the inner wall of the drum.

[0011] In one possible design, the bottom of the ring is symmetrically fixed with two positioning pins for assisting in aligning the fastening bolt holes, and the inner wall of the drum is provided with positioning slots for inserting the corresponding positioning pins.

[0012] This utility model also provides a biopharmaceutical purification device, including the modular separation component described in any one of the above, and a hollow sealed chamber. The bottom of the hollow sealed chamber is fixedly connected to the top of the substrate. The transmission rod and the rotating drum are both located inside the hollow sealed chamber. A matching chamber cover is provided at the top of the chamber opening by a sealing ring. The top of the chamber cover is connected to a feed pipe and a rectangular block. A U-shaped skimming pipe for skimming is slidably arranged inside the rectangular block. The other end of the U-shaped skimming pipe passes through the cavity inside the rectangular block and extends to the upper edge near the inner wall of the rotating drum.

[0013] In one possible design, a mounting plate is fixedly installed at the top edge of the rectangular block, and an electric push rod for moving the U-shaped skimming tube laterally to disassemble the rotating drum is fixedly installed in the center of the mounting plate. A connecting plate is fixedly installed at the output end of the electric push rod, and the inner wall of the through hole at the lower end of the connecting plate is glued to the outer wall of the U-shaped skimming tube.

[0014] In one possible design, the top of the bin cover is inclined to have an observation tube for observing the processing status, and a transparent sheet is embedded in the top of the observation tube.

[0015] It should be understood that the above general description and the following detailed description are merely exemplary and do not limit the present invention.

[0016] The working principle and usage process of this technical solution are as follows:

[0017] During installation, the drum is fitted onto the transmission rod, and the protrusion on the transmission rod is inserted into the slot in the drum's insertion hole to achieve axial positioning. Then, the ring is fitted onto the top of the transmission rod, and the positioning pin is inserted into the positioning slot on the inner wall of the drum. The ring is then threaded to the inner wall of the drum using fastening bolts. Finally, the top of the transmission rod is locked with a nut. After closing the hopper cover, the snap fasteners on the outer wall are fastened to seal the hopper opening. The feed pipe is then connected to the external feeding system.

[0018] In use, start the drive motor to rotate the transmission rod and the drum to the set speed, forming a stable centrifugal force field. The biological suspension (such as cell culture medium or fermentation broth) is pumped into the drum through the feed pipe. Under the action of centrifugal force, the liquid forms an annular liquid layer, and the solid particles settle to the inner wall of the drum to form sludge. The clarified separated liquid gathers in the center of the drum. When the liquid level rises to the end of the U-shaped skimming tube, it enters the skimming tube under the action of centrifugal force and is discharged from the sealed chamber, realizing continuous liquid discharge. After the separation is completed, stop feeding and reduce the speed. Push the U-shaped skimming tube to move laterally and back by the electric push rod to make room for the drum to be disassembled. Then open the chamber cover, remove the fastening bolts and nuts, remove the drum and clean the sludge.

[0019] This utility model has the following beneficial effects:

[0020] In this invention, two symmetrically fixed protrusions on the transmission rod engage with the slots on the inner wall of the insertion hole, and the ring is connected to the inner wall of the drum by fastening bolts. With the fastening effect of the nut, the stability during operation is improved, which helps to ensure the smooth progress of the separation process and the separation quality. Furthermore, the connection between each component is detachable, which facilitates the assembly, disassembly and maintenance of the equipment.

[0021] In this invention, an electric push rod drives the U-shaped skimming tube to move laterally. When it is necessary to disassemble the drum for cleaning or replacement, the electric push rod can move the U-shaped skimming tube away, providing convenient space for the disassembly of the drum and improving the ease of operation and maintenance efficiency of the equipment.

[0022] The top of the central chamber cover of this utility model is inclined and connected to an observation tube, and an embedded transparent sheet is set at the top of the observation tube. The staff can observe the processing of the rotating drum inside the hollow sealed chamber at any time through the transparent sheet, and understand the separation progress and equipment operation status in a timely manner. Attached Figure Description

[0023] Figure 1 This is a three-dimensional structural diagram provided for an embodiment of the present utility model;

[0024] Figure 2 This is a schematic diagram of the hollow sealed chamber and chamber cover separation structure provided in an embodiment of the present utility model;

[0025] Figure 3 This is a schematic diagram of the internal structure of the hollow sealed chamber provided in an embodiment of the present utility model;

[0026] Figure 4 This is a schematic diagram of the separation structure of the transmission rod and the drum provided in an embodiment of the present utility model.

[0027] Reference numerals: 1. Base plate; 2. Hollow sealed chamber; 3. Transmission rod; 4. Drum cylinder; 5. Insertion hole; 6. Protrusion; 7. Slot; 8. Ring; 9. Positioning pin; 10. Positioning slot; 11. Fastening bolt; 12. Nut; 13. Chamber cover; 14. Feed pipe; 15. Rectangular block; 16. U-shaped skimming pipe; 17. Mounting plate; 18. Electric push rod; 19. Connecting plate; 20. Observation tube; 21. Transparent sheet; 22. Drive motor. Detailed Implementation

[0028] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of the present utility model.

[0029] In the description of this utility model, it should be understood that the terms "opening", "upper", "middle", "length", "inner", etc., which indicate orientation or positional relationship, are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the components or elements referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model.

[0030] To keep the following description of the embodiments of this utility model clear and concise, detailed descriptions of known functions and known components are omitted.

[0031] In one embodiment:

[0032] Please refer to Figure 1-4 A modular, separable component, comprising:

[0033] The base plate 1 is a rectangular metal plate. A transmission rod 3 is rotatably mounted on the top center of the base plate via a deep groove ball bearing. The transmission rod 3 is a cylindrical metal rod with a smooth surface and an external thread at the top. Two protrusions 6 are symmetrically welded on the transmission rod 3. The protrusions 6 are cuboid metal blocks perpendicular to the axis of the transmission rod 3. The drum cylinder 4 is a cylindrical stainless steel container with an insertion hole 5 in the center. The inner wall of the insertion hole 5 has symmetrical slots 7. The shape of the slots 7 is adapted to the protrusions 6. During installation, the drum cylinder 4 is inserted into the transmission rod 3, so that the protrusions 6 are embedded in the slots 7 to achieve axial positioning.

[0034] The ring 8 is a stainless steel ring with a through hole in the center and two positioning pins 9 symmetrically welded to the bottom. The positioning pins 9 are cylindrical metal rods. The inner wall of the drum 4 has a corresponding positioning slot 10. The shape of the positioning slot 10 is adapted to the positioning pin 9. The ring 8 is put into the top of the transmission rod 3 so that the positioning pin 9 is inserted into the positioning slot 10, thereby achieving the initial fixation and radial positioning of the ring 8 and the drum 4, and preventing the ring 8 from shifting during rotation.

[0035] Two through holes are made on the ring 8. The stainless steel fastening bolt 11 passes through the through holes and is threaded to the threaded groove on the inner wall of the drum 4 to further fix the ring 8. The top of the transmission rod 3 is connected to the nut 12 by the external thread. The nut 12 is a hexagonal stainless steel nut. After tightening, it presses the ring 8 to ensure the stable connection between the drum 4 and the transmission rod 3 and prevent the components from loosening.

[0036] A drive motor 22 is fixedly installed at the bottom center of the substrate 1. The drive motor 22 is a servo motor with a power of 1.5kW and a speed range of 0-5000rpm. Its output shaft passes through the top of the substrate 1 and is fixedly connected to the bottom of the transmission rod 3 through a coupling. When the drive motor 22 is running, it drives the transmission rod 3 and the drum 4 to rotate.

[0037] A biopharmaceutical purification device includes the aforementioned modular separation components, and also includes a hollow sealed chamber 2. The hollow sealed chamber 2 is a cylindrical stainless steel container, with its bottom fixedly connected to the top of the base plate 1 by bolts. The transmission rod 3 and the rotating drum 4 are located inside the hollow sealed chamber 2. A silicone rubber sealing ring is provided at the top opening of the hollow sealed chamber 2. The chamber cover 13 is a circular metal cover, which is snapped onto the opening by the sealing ring and sealed and fixed by fasteners.

[0038] Two through holes are opened at the top of the bin cover 13, which are respectively connected to the feed pipe 14 and the rectangular block 15. The feed pipe 14 is a stainless steel pipe, one end of which is connected to the external feeding system. The feeding system controls the feed flow rate through a peristaltic pump, with a flow rate range of 0-5L / min. The other end extends to the top of the drum 4. The rectangular block 15 is a cuboid metal block with a transverse sliding cavity inside. The U-shaped skimming pipe 16 is a U-shaped stainless steel pipe. One end is slidably set in the sliding groove of the rectangular block 15 and connected to the external drainage system. The other end extends to the upper edge of the inner wall of the drum 4, 5mm away from the inner wall, and is used to skim off the clarified and separated liquid.

[0039] A mounting plate 17 is welded to the top edge of the rectangular block 15. The mounting plate 17 is a rectangular stainless steel plate. An electric push rod 18 is fixed in the center by bolts. The electric push rod 18 is a linear push rod. A connecting plate 19 is welded to the output end. A through hole is opened at the lower end of the connecting plate 19. The outer wall of the U-shaped skimming tube 16 is glued and fixed in the through hole, so as to realize the lateral movement control of the U-shaped skimming tube 16 by the electric push rod 18.

[0040] The top of the cover 13 is tilted and connected to the observation tube 20. The observation tube 20 is a stainless steel pipe with a transparent sheet 21 embedded in the top. The transparent sheet 21 is made of plexiglass. A scraper is mounted on the bottom center of the transparent sheet 21 via a miniature bearing. The scraper is a thin stainless steel rod that fits against the bottom of the transparent sheet 21. An anti-slip cap is set at the top center of the transparent sheet 21. The anti-slip cap is a cylindrical plastic part with its bottom end penetrating the inner wall of the transparent sheet 21 and fixedly connected to the top of the scraper. By rotating the anti-slip cap, the scraper can be driven to scrape away impurities at the bottom of the transparent sheet 21, ensuring clear observation.

[0041] During the installation phase, the drum 4 is fitted onto the transmission rod 3, and the protrusion 6 is embedded into the slot 7 to achieve axial positioning. The ring 8 is fitted onto the top of the transmission rod 3, and the positioning pin 9 is inserted into the positioning slot 10. The ring 8 and the drum 4 are fixed by the fastening bolt 11. The nut 12 is tightened to press the ring 8, ensuring a stable connection between the drum 4 and the transmission rod 3. After closing the cover 13, the fastener is fastened to achieve a seal, and the feed pipe 14 is connected to the external feeding system.

[0042] During operation, after the drive motor 22 is started, it drives the transmission rod 3 and the drum 4 to rotate to the set speed, forming a stable centrifugal force field. Biological suspension (such as cell culture medium) is pumped into the drum 4 through the feed pipe 14. Under the action of centrifugal force, the liquid forms an annular liquid layer, and the solid particles settle to the inner wall of the drum 4 to form sludge. The clarified separated liquid gathers in the center of the drum. When the liquid level rises to the end of the U-shaped skimming pipe 16, it enters the skimming pipe under the action of centrifugal force and is discharged from the sealed chamber, realizing continuous liquid discharge.

[0043] During the maintenance phase, after separation is completed, stop feeding and reduce the rotation speed. Start the electric push rod 18 to push the U-shaped skimming tube 16 to move laterally and make room for disassembly of the drum 4. Then open the bin cover 13, remove the fastening bolts 11 and nuts 12, remove the drum 4 and clean the sediment. If there are impurities at the bottom of the transparent sheet 21 that affect observation, rotate the anti-slip cap to drive the scraper to clean the bottom of the transparent sheet 21 to ensure clear observation.

[0044] This application can be used for biopharmaceutical separation, or for other fields applicable to this application.

[0045] Those skilled in the art should understand that the selection and configuration of the electric actuator 18 and the drive motor 22 are conventional technical means. In specific implementations, the selection can be made according to the performance requirements of the actual application scenario (including but not limited to thrust parameters, stroke range, response speed, etc.). The above-mentioned specific implementation details are all well-known technologies in the field and will not be elaborated further here.

[0046] The accompanying drawings in this application are for illustrative purposes only. The dimensions and shapes of the components shown are not actual limitations but are merely schematic representations. In actual implementation, the components can be reasonably configured and adjusted according to specific needs and actual conditions.

[0047] The above are merely specific embodiments of this utility model, but the protection scope of this utility model is not limited thereto. Any variations or substitutions that can be easily conceived by those skilled in the art within the technical scope disclosed in this utility model should be included within the protection scope of this utility model. In the absence of conflict, the embodiments and features in the embodiments of this utility model can be combined with each other. Therefore, the protection scope of this utility model should be determined by the scope of the claims.

Claims

1. A modular separation module, characterized in that, include: A base plate (1) has a transmission rod (3) rotatably mounted on the center of the top of the base plate (1) via a bearing. A rotating drum (4) is detachably mounted on the transmission rod (3). A hole (5) for the transmission rod (3) to pass through is provided in the center of the rotating drum (4). A ring (8) is fitted on the transmission rod (3). The bottom of the ring (8) is tightly against the center of the inner wall of the rotating drum (4). The top of the transmission rod (3) passes through the through hole in the center of the ring (8) and is connected to a matching nut (12) by the external thread at the top. A drive motor (22) for driving the transmission rod (3) to rotate is fixedly installed at the center of the bottom of the substrate (1). The output shaft of the drive motor (22) passes through the top of the substrate (1) and is fixedly connected to the bottom end of the transmission rod (3).

2. A modular separation assembly according to claim 1, wherein, Two protrusions (6) are symmetrically fixed on the transmission rod (3) to prevent the drum (4) from slipping off, and a slot (7) for inserting the corresponding protrusion (6) is provided on the inner wall of the insertion hole (5).

3. The modular separation assembly of claim 1, wherein, The two through holes on the ring (8) are each provided with a corresponding fastening bolt (11), and the end of the fastening bolt (11) is threadedly connected to the corresponding threaded groove on the inner wall of the drum (4).

4. A modular separation assembly according to claim 3, wherein, The bottom of the ring (8) is symmetrically fixed with two positioning pins (9) for aligning the holes of the fastening bolts (11), and the inner wall of the drum (4) is provided with positioning slots (10) for inserting the corresponding positioning pins (9).

5. A biopharmaceutical purification apparatus, characterized by, The modular separation assembly, including any one of claims 1 to 4, further includes a hollow sealed chamber (2), the bottom of which is fixedly connected to the top of the substrate (1), the transmission rod (3) and the drum (4) are both located inside the hollow sealed chamber (2), and a matching chamber cover (13) is provided at the top of the chamber opening of the hollow sealed chamber (2) by a sealing ring, the top of which is connected to a feed pipe (14) and a rectangular block (15), and a U-shaped skimming pipe (16) for skimming is slidably arranged inside the rectangular block (15), the other end of which penetrates the cavity inside the rectangular block (15) and extends to the upper edge of the inner wall of the drum (4).

6. The biopharmaceutical purification apparatus of claim 5, wherein, An installation plate (17) is fixedly installed at the top edge of the rectangular block (15). An electric push rod (18) for driving the U-shaped skimming tube (16) to move laterally so as to disassemble the drum (4) is fixedly installed in the center of the installation plate (17). A connecting plate (19) is fixedly installed at the output end of the electric push rod (18). The inner wall of the through hole at the lower end of the connecting plate (19) is glued to the outer wall of the U-shaped skimming tube (16).

7. The biopharmaceutical purification apparatus of claim 5, wherein, The top of the bin cover (13) is inclined to be connected to an observation tube (20) for observing the processing situation, and a transparent sheet (21) is embedded in the top of the observation tube (20).

Images