A semi-automatic bone marrow cell morphology washing slide instrument

Abstract

This utility model relates to a semi-automatic bone marrow cell morphology slide washing instrument, comprising: a washing chamber with multiple slots for holding slides; and a robotic arm equipped with a washing head for driving the washing head to move. By holding the slides in the slots and using the robotic arm to drive the washing head, the water flow and angle can be controlled, reducing cell detachment. The closed washing chamber design allows the operator to have zero contact with the staining solution, improving operational safety. Multiple slides can be processed at a time, increasing washing efficiency.

Description

Technical Field

[0001] This utility model relates to the field of medical device technology, specifically to a semi-automatic bone marrow cell morphology washing slide instrument. Background Technology

[0002] Bone marrow cell morphology examination is mainly used to observe changes in cell morphology and quantity in bone marrow smears, assess bone marrow hematopoiesis, and for the diagnosis, differential diagnosis, and monitoring of treatment efficacy in hematological diseases. Its core steps include smear preparation, staining, rinsing, and microscopic examination. The rinsing step requires removing excess staining solution (Wright's stain) from the slide surface using running water, without damaging the cell membranes. Requirements include: stable water pressure (excessive pressure can cause cell detachment, while insufficient pressure results in poor staining due to residual dye, interfering with diagnosis); controllable water flow angle (vertical rinsing can damage the cell layer); and uniform rinsing to avoid localized staining differences.

[0003] Currently, clinical practice mainly relies on manual rinsing, which has three major drawbacks: high operator dependence, with differences in operator technique leading to a high rate of cell detachment and affecting slide quality; biosafety risks, as operators come into direct contact with the staining solution, posing a potential biological hazard; and low efficiency, with each slide taking ≥2 minutes to rinse and requiring continuous manual adjustment of the water flow, which is time-consuming and labor-intensive. Utility Model Content

[0004] Based on the above description, this utility model provides a semi-automatic bone marrow cell morphology washing slide instrument to solve the problems of high operator dependence, biosafety risks, and low efficiency in related technologies.

[0005] The technical solution of this utility model to solve the above-mentioned technical problems is as follows: A semi-automatic bone marrow cell morphology washing slide instrument, comprising: a washing chamber with multiple slots inside for holding slides; and a robotic arm with a washing head installed thereon for driving the washing head to move.

[0006] Based on the above technical solution, the present invention can be further improved as follows.

[0007] Furthermore, the slot is V-shaped and has elasticity.

[0008] Furthermore, multiple slots are arranged vertically in sequence within the flushing chamber.

[0009] Furthermore, the inner width of the slot is 1.0~1.5 mm.

[0010] Furthermore, the rinsing head has a main rinsing port in the center and auxiliary rinsing ports on both sides.

[0011] Furthermore, the diameter of the main flushing port is larger than that of the auxiliary flushing port.

[0012] Furthermore, an ultraviolet disinfection lamp is installed on the inside of the flushing chamber.

[0013] Furthermore, a lifting platform is installed at the bottom of the flushing chamber.

[0014] Furthermore, the flushing chamber is made of transparent polycarbonate material.

[0015] Furthermore, the robotic arm is a multi-axis robotic arm.

[0016] Compared with the prior art, the technical solution of this application has the following beneficial technical effects:

[0017] By attaching the slides to the slots and using a robotic arm to drive the rinsing head, the water flow and angle can be controlled, reducing cell shedding. The closed rinsing chamber design allows the operator to have zero contact with the staining solution, improving operational safety. Multiple slides can be processed at a time, increasing rinsing efficiency. Attached Figure Description

[0018] Figure 1 A schematic diagram of the overall structure of the semi-automatic bone marrow cell morphology washing slide instrument provided in this embodiment of the utility model;

[0019] Figure 2 This is a schematic diagram of the card slot provided in an embodiment of the present utility model;

[0020] Figure 3 This is a schematic diagram of the structure of the flushing head provided in an embodiment of the present utility model.

[0021] The attached diagram lists the components represented by each number as follows:

[0022] 1. Flushing chamber; 2. Card slot; 3. Robotic arm; 4. Flushing head; 41. Main flushing port; 42. Auxiliary flushing port. Detailed Implementation

[0023] To facilitate understanding of this application, a more complete description will be provided below with reference to the accompanying drawings, which illustrate embodiments of the present application. However, the present application can be implemented in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided so that the disclosure of this application will be thorough and complete.

[0024] This invention provides a semi-automatic bone marrow cell morphology washing slide instrument, which can solve the problems of high operator dependence, biosafety risks, and low efficiency in related technologies.

[0025] See Figure 1As shown in the figure, a semi-automatic bone marrow cell morphology rinsing slide instrument provided in this embodiment of the present invention includes: a rinsing chamber 1, which has multiple slots 2 inside for holding slides; and a robotic arm 3, which is equipped with a rinsing head 4 for driving the rinsing head 4 to move.

[0026] See Figure 1 As shown, in some embodiments, the slot 2 is V-shaped and elastic, which improves compatibility and can be adapted to glass slides of any length and width.

[0027] See Figure 2 As shown, in some embodiments, multiple slots 2 are arranged vertically in sequence within the rinsing chamber 1, which can process multiple glass slides at a time, thus improving rinsing efficiency.

[0028] See Figure 1 As shown, in some embodiments, the inner width of the slot 2 is 1.0~1.5 mm, and the slot 2 has a built-in pressure sensing spring, which can be compatible with glass slides of different thicknesses.

[0029] See Figure 3 As shown, in some embodiments, the flushing head 4 has a main flushing port 41 in the center and auxiliary flushing ports 42 on both sides. By setting a three-way spray structure, an enveloping water flow is formed, reducing edge turbulence.

[0030] See Figure 3 As shown, in some embodiments, the diameter of the main flushing port 41 is larger than that of the auxiliary flushing port 42. The diameter of the main flushing port 41 is preferably 1.0 mm, and the diameter of the auxiliary flushing ports 42 on both sides is preferably 0.5 mm, which is conducive to forming an enveloping water flow.

[0031] See Figure 1 As shown, in some embodiments, an ultraviolet disinfection lamp is installed on the inner side of the rinsing chamber 1 to reduce slide contamination.

[0032] See Figure 1 As shown, in some embodiments, a lifting seat is installed at the bottom of the flushing chamber 1 to drive the flushing chamber 1 to rise and fall, so that the flushing chamber 1 can be stored in the box to reduce pollution.

[0033] See Figure 1 As shown, in some embodiments, the rinsing chamber 1 is made of transparent polycarbonate material, which has high transparency and makes it easy to observe the rinsing of the glass slides.

[0034] See Figure 1 As shown, in some embodiments, the robotic arm 3 is a multi-axis robotic arm that can coordinate the movement of multiple joints or axes, and has a high degree of freedom.

[0035] In some embodiments, the semi-automatic bone marrow cell morphology rinsing slide instrument also includes a termination control system that can control the rinsing time.

[0036] Workflow:

[0037] Place the staining rack (containing the slide) into the rinsing chamber 1;

[0038] The robotic arm positions the rinsing head 2cm above the center of the first glass slide.

[0039] Start the multi-stage flushing:

[0040] Stage 1: Low-pressure pre-flushing (0.5 kPa, 5s) to remove floating color;

[0041] Phase 2: Main rinse (1.0 kPa, 15 s) for targeted removal of bound dyes;

[0042] Once the standard is met, move to the next slide. The entire process takes ≤4 minutes per 8 slides.

[0043] The semi-automatic bone marrow cell morphology washing slide instrument provided in this application has the following advantages through its modular mechanical structure and intelligent sensor control:

[0044] 1. Protect the cell membrane of the glass slide

[0045] Water flow control, ensuring the correct water flow angle, reduces cell shedding rate to <5%.

[0046] 2. Enhance operational safety

[0047] The enclosed rinsing chamber design ensures zero contact between the operator and the dye solution, meeting ISO 15190 biosafety standards.

[0048] 3. Optimize efficiency and economy

[0049] Processes 32 slides at a time (compatible with standard staining racks), improving washing efficiency by 300%.

[0050] Compatibility and intelligence, adaptable to any length and width of glass slide (25×75 mm to 30×90 mm).

[0051] The comparative tests are as follows:

[0052] Equipment group: Use this instrument (phosphate buffer, pH 6.8)

[0053] Control group: Manual rinsing by experienced technicians (using the same buffer solution)

[0054] Samples: 100 bone marrow specimens from acute myeloid leukemia (AML), with duplicate smears prepared for each specimen.

[0055]

[0056] As shown in the table above, the glass slides in the equipment group had intact cell structures and no dye crystals, while the glass slides in the control group had local cell layer defects and dye deposition. This indicates that the equipment in this application is significantly superior to manual operation in terms of key performance indicators, and the modular design reduces maintenance costs by 75% (only the flushing head filter needs to be replaced).

[0057] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the application.

[0058] It is understood that spatial relation terms such as "below," "under," "below," "below," "above," "above," etc., can be used here to describe the relationship between one element or feature shown in the figure and other elements or features. It should be understood that, in addition to the orientation shown in the figure, spatial relation terms also include different orientations of the device in use and operation. For example, if the device in the figure is flipped, the element or feature described as "below" or "below" of the other element or feature will be oriented "above" the other element or feature. Therefore, the exemplary terms "below" and "below" can include both upper and lower orientations. Furthermore, the device may also include other orientations (e.g., rotated 90 degrees or other orientations), and the spatial descriptive terms used herein will be interpreted accordingly.

[0059] It should be noted that when one element is considered to be "connected" to another element, it can be directly connected to the other element or connected to the other element through an intermediary element. In the following embodiments, "connection" should be understood as "electrical connection," "communication connection," etc., if the connected circuits, modules, units, etc., have the transmission of electrical signals or data between them.

[0060] When used herein, the singular forms of “a,” “an,” and “the” may also include the plural forms unless the context clearly indicates otherwise. It should also be understood that the terms “comprising,” “including,” or “having,” etc., specify the presence of the stated feature, whole, step, operation, component, part, or combination thereof, but do not preclude the possibility of the presence or addition of one or more other features, wholes, steps, operations, components, parts, or combinations thereof.

[0061] The above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A semi-automatic bone marrow cell morphological flush slide apparatus, characterized by, It includes: The rinsing chamber (1) is provided with multiple slots (2) inside, which are used to hold glass slides; A robotic arm (3) is equipped with a rinsing head (4), which is used to drive the rinsing head (4) to move.

2. The semi-automatic bone marrow cell morphology washing slide instrument according to claim 1, characterized in that: The slot (2) is V-shaped and elastic.

3. The semi-automatic bone marrow cell morphology washing slide instrument according to claim 2, characterized in that: Multiple slots (2) are arranged vertically in sequence inside the flushing chamber (1).

4. The semi-automatic bone marrow cell morphology washing slide instrument according to claim 2, characterized in that: The inner width of the slot (2) is 1.0~1.5 mm.

5. The semi-automatic bone marrow cell morphology washing slide instrument according to claim 1, characterized in that: The flushing head (4) has a main flushing port (41) in the center and auxiliary flushing ports (42) on both sides.

6. The semi-automatic bone marrow cell morphology washing slide instrument according to claim 5, characterized in that: The diameter of the main flushing port (41) is larger than that of the auxiliary flushing port (42).

7. The semi-automatic bone marrow cell morphology washing slide instrument according to claim 1, characterized in that: The inner side of the flushing chamber (1) is equipped with an ultraviolet disinfection lamp.

8. The semi-automatic bone marrow cell morphology washing slide instrument according to claim 1, characterized in that: The bottom of the flushing chamber (1) is equipped with a lifting seat.

9. The semi-automatic bone marrow cell morphology washing slide instrument according to claim 1, characterized in that: The flushing chamber (1) is made of transparent polycarbonate.

10. The semi-automatic bone marrow cell morphology washing slide instrument according to claim 1, characterized in that: The robotic arm (3) is a multi-axis robotic arm.

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