An apparatus for assisting thrombosis of a rat arteriovenous shunt

Abstract

The utility model discloses a device of auxiliary rat arteriovenous bypass thrombosis, including the flat plate, the upper surface of flat plate is provided with the catheter and catheter fixed structure, the catheter fixed structure includes a plurality of limiting components, a plurality of limiting components are n -shaped arrangement and fixed mounting on the upper surface of flat plate, the catheter is along the arrangement track of limiting component to set up, and passes through the inside of every limiting component in proper order. The auxiliary device disclosed by the utility model avoids the problem of blood flow not being smooth caused by the catheter bending, fully guarantees the smoothness of blood in extracorporeal circulation, improves the efficiency of thrombosis, and is favorable to the construction of drug screening model.

Description

Technical Field

[0001] This invention relates to the field of pharmacological model making technology, specifically to a device for assisting in the formation of arteriovenous bypass thrombosis in rats. Background Technology

[0002] The rat arteriovenous bypass thrombosis model is a commonly used screening model for antiplatelet aggregation drugs, antithrombotic drugs, and thrombolytic drugs. In the process of creating this model, an arteriovenous bypass catheter for in vitro thrombus formation is first prepared, with thinner catheters connected to both ends. During the preparation of the arteriovenous bypass thrombus, the catheter placed outside the body often experiences bending tension, causing varying degrees of bending at the insertion end connected to the common carotid artery / external jugular vein. This bending affects the smoothness of blood flow, sometimes even completely blocking it, leading to model failure.

[0003] Therefore, in order to avoid the problem of poor blood flow caused by the bending of the catheter insertion end, there is an urgent need in this field to develop a novel device to assist in the formation of arteriovenous bypass thrombosis in rats, so as to fully ensure the smooth circulation of blood in the body, improve the efficiency of thrombosis formation, and facilitate the construction of drug screening models. Utility Model Content

[0004] To solve the above-mentioned technical problems, this utility model provides a device for assisting in the formation of arteriovenous bypass thrombosis in rats, including a plate. The upper surface of the plate is provided with a catheter and a catheter fixing structure. The catheter fixing structure includes multiple limiting components. The multiple limiting components are arranged in an n-shape and fixedly installed on the upper surface of the plate. The catheter is arranged along the arrangement trajectory of the limiting components and passes through the interior of each limiting component in sequence.

[0005] In one specific embodiment, the limiting component is a semi-circular ring or an inverted L-shaped column.

[0006] In one specific embodiment, the top of the plate is provided with a plurality of circular holes, and the bottom end of the semi-circular ring or inverted L-shaped column is fixedly installed in the circular holes.

[0007] In one specific embodiment, a base is fixedly installed at the bottom end of the plate. The base has an n-shaped structure, and the hollow part of the n-shaped structure is used to accommodate the head of the rat.

[0008] In one specific embodiment, at least three limiting components are provided.

[0009] In one specific embodiment, the flat plate is made of acrylic material, and the thickness of the flat plate is 3-5mm, the length is 5-8cm, and the width is 5-8cm.

[0010] In one specific embodiment, the plate has a thickness of 3mm, a length of 6cm, and a width of 6cm.

[0011] In one specific embodiment, the base has a thickness of 0.5-1.0cm, a length of 3-5cm, a width of 3-5cm, and a bottom width of 0.5cm for the n-shaped structure.

[0012] In one specific embodiment, the base has a thickness of 0.8 cm, a length of 4 cm, and a width of 4 cm.

[0013] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0014] 1. The device for assisting in the formation of arteriovenous bypass thrombosis in rats provided by this utility model can fix the shape of the catheter within a certain range through the setting of the catheter fixing structure and limiting components, thereby preventing excessive bending of the catheter, ensuring the smooth flow of blood in the extracorporeal circulation, facilitating thrombus formation, and improving the efficiency of thrombus formation.

[0015] 2. The device for assisting in the formation of arteriovenous bypass thrombosis in rats provided by this utility model has a simple structure and is easy to operate, which improves the practicality of the device. The n-shaped structure of the base facilitates the placement of the rat's head. Attached Figure Description

[0016] Figure 1 This is a structural schematic diagram from the main viewpoint of this utility model;

[0017] Figure 2 This is a top-view structural schematic diagram of the present invention;

[0018] In the diagram, 1 is a flat plate; 2 is a limiting component; 3 is a conduit; and 4 is a base. Detailed Implementation

[0019] The technical solution of this utility model will be clearly and completely described below. Obviously, the described embodiments are only some, not all, of the embodiments of this utility model. Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this utility model. Unless otherwise specified, the materials, instruments, and reagents used in the following embodiments can be obtained commercially. Unless otherwise specified, the technical means used in the embodiments are conventional means well known to those skilled in the art.

[0020] The structures, proportions, sizes, etc., illustrated in the accompanying drawings of this specification are only for illustrative purposes and to facilitate understanding and reading by those skilled in the art. They are not intended to limit the implementation conditions of this utility model and therefore have no substantial technical significance. Any modifications to the structure, changes in proportions, or adjustments to size, without affecting the effects and objectives of this utility model, should still fall within the scope of the technical content disclosed in this utility model. Furthermore, the terms such as "upper," "lower," "left," "right," "middle," and "one" used in this specification are merely for clarity of description and are not intended to limit the scope of implementation of this utility model. Changes or adjustments to their relative relationships, without substantially altering the technical content, should also be considered within the scope of implementation of this utility model.

[0021] Example 1

[0022] like Figure 1-2 This invention illustrates a device for assisting in the formation of arteriovenous bypass thrombosis in rats, comprising a plate 1. A catheter 3 and a catheter 3 fixing structure are disposed on the upper surface of the plate 1. The catheter 3 fixing structure includes multiple limiting components 2, arranged in an n-shape and fixedly mounted on the upper surface of the plate 1. The catheter 3 is positioned along the arrangement trajectory of the limiting components 2 and passes sequentially through the interior of each limiting component 2. The limiting component 2 is a semi-circular arch or an inverted L-shaped column. In actual operation, the limiting component 2 can be selected according to the possible bending angle of the catheter 3. If the catheter 3 tends to bend inward, a semi-circular arch can be selected for internal support and fixation; if the catheter 3 tends to bend outward, an L-shaped column can be selected for external support and fixation. At least three limiting components 2 are provided in this embodiment. Figure 2 In the middle, the limiting component 2 is provided with 6, which provides better fixation for the conduit 3.

[0023] A base 4 is fixedly installed at the bottom of the plate 1. The base 4 has an n-shaped structure, and the hollow part of the n-shaped structure is used to accommodate the rat's head. The space is more reasonable, allowing for more flexible placement of the catheter 3, maximizing the alignment of the vascular insertion end with the vascular direction, and is also more suitable for experimental mice of various body sizes.

[0024] The top of the plate 1 has multiple circular holes with a diameter of approximately 1 mm. The bottom of a semi-circular ring or inverted L-shaped column is fixedly installed in the circular holes, and the height of the semi-circular ring or inverted L-shaped column is approximately 0.8 cm. The plate 1 is made of acrylic material. In a preferred embodiment, the plate 1 has a thickness of 3 mm, a length of 6 cm, and a width of 6 cm. The base 4 has a thickness of 0.8 cm, a length of 4 cm, and a width of 4 cm. The bottom width of the n-shaped structure is 0.5 cm. This device has reasonable dimensions, is lightweight, and is suitable for rats weighing 200g-500g, assisting in in vitro thrombus formation, and has good practicality.

[0025] Detailed operation process:

[0026] The catheter 3 was pre-filled with heparinized saline and passed through the limiting component 2, then fixed to the plate 1, ensuring that the distal end of the catheter 3, near the blood vessel, was parallel to the direction of the blood vessel. Next, the rat (weighing 200-500g) was anesthetized, its head positioned in the hollow part of the n-shaped structure of the base 4, and a routine vascular dissection was performed to expose the right common carotid artery and the left external jugular vein. Finally, the two ends of the catheter 3 were inserted into the artery and vein respectively, and the catheter 3 was ligated and fixed.

[0027] As can be seen, by using the auxiliary device provided in this embodiment, the extracorporeal circulation catheter can be flexibly placed according to the weight of the experimental animal, avoiding bending of the catheter and fully ensuring the smooth flow of blood in extracorporeal circulation.

[0028] In summary, the above embodiments are merely preferred embodiments of the present utility model and are not intended to limit the scope of protection of the present utility model. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the scope of protection of the present utility model.

Claims

1. A device for assisting in the formation of arteriovenous bypass thrombosis in rats, comprising a plate (1), characterized in that, The upper surface of the plate (1) is provided with a conduit (3) and a conduit (3) fixing structure. The conduit (3) fixing structure includes multiple limiting components (2). The multiple limiting components (2) are arranged in an n-shape and fixedly installed on the upper surface of the plate (1). The conduit (3) is arranged along the arrangement trajectory of the limiting components (2) and passes through the interior of each limiting component (2) in sequence.

2. The device for assisting in the formation of arteriovenous bypass thrombosis in rats according to claim 1, characterized in that, The limiting component (2) is a semi-circular ring or an inverted L-shaped column.

3. The device for assisting in the formation of arteriovenous bypass thrombosis in rats according to claim 2, characterized in that, The top of the plate (1) has multiple circular holes, and the bottom end of the semi-circular ring or inverted L-shaped column is fixedly installed in the circular holes.

4. The device for assisting in the formation of arteriovenous bypass thrombosis in rats according to claim 1, characterized in that, The bottom end of the plate (1) is fixedly installed with a base (4), which is an n-shaped structure. The hollow part of the n-shaped structure is used to accommodate the head of the rat.

5. The device for assisting in the formation of arteriovenous bypass thrombosis in rats according to claim 1, characterized in that, The limiting component (2) is provided with at least 3.

6. The device for assisting in the formation of arteriovenous bypass thrombosis in rats according to claim 1, characterized in that, The plate (1) is made of acrylic material, and the plate (1) has a thickness of 3-5mm, a length of 5-8cm, and a width of 5-8cm.

7. The device for assisting in the formation of arteriovenous bypass thrombosis in rats according to claim 1, characterized in that, The plate (1) has a thickness of 3mm, a length of 6cm, and a width of 6cm.

8. The device for assisting in the formation of arteriovenous bypass thrombosis in rats according to claim 4, characterized in that, The base (4) has a thickness of 0.5-1.0cm, a length of 3-5cm, a width of 3-5cm, and a bottom width of 0.5cm for the n-shaped structure.

9. The device for assisting in the formation of arteriovenous bypass thrombosis in rats according to claim 8, characterized in that, The base (4) has a thickness of 0.8cm, a length of 4cm, and a width of 4cm.

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