Blood purification device
By incorporating a detachable connecting ring into the blood purification device, the problem of the hollow fiber bundle and the end cap being stuck together is solved, enabling the detachable replacement of the hollow fiber bundle and the reuse of the end cap, thereby reducing the manufacturing cost of the blood purification device.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- JAFRON BIOMEDICAL
- Filing Date
- 2025-07-24
- Publication Date
- 2026-07-07
AI Technical Summary
In existing blood purification devices, the hollow fiber bundles cannot be separated from the end caps after they are bonded together, which means that the devices can only be used as disposable items, increasing costs.
A connecting ring is provided on the fiber bundle assembly. The end of the hollow fiber bundle is connected to the connecting ring through a cured adhesive layer. The connecting ring is detachably connected to the inside of the end cap, isolating the cured adhesive layer from the end cap, thus achieving the detachability of the fiber bundle assembly.
The hollow fiber bundles can be detached and replaced, reducing the manufacturing cost of blood purification devices. Furthermore, the end caps and cylinders can be reused, further reducing production costs.
Smart Images
Figure CN224462776U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of blood purification technology, and more specifically, to a blood purification device. Background Technology
[0002] The core of a blood purification device is a hollow fiber filament tube with numerous small pores. Related technologies typically use a colloid to encapsulate the hollow fiber bundle at the end of the device. However, the hollow fiber bundle becomes contaminated after use, making the blood purification device a single-use item. After use, the entire device needs to be replaced, resulting in high costs and increasing the overall cost of blood purification. Utility Model Content
[0003] The present invention aims to address the aforementioned deficiencies of the prior art by providing a blood purification device with replaceable hollow fiber bundles, which helps to reduce the manufacturing cost of the blood purification device.
[0004] To address the above problems, this utility model provides a blood purification device, comprising:
[0005] A cylindrical body, wherein the cylindrical body is provided with a receiving cavity, and the receiving cavity has openings at both ends;
[0006] Two end-sealing components are detachably connected to both ends of the cylinder, and the two end-sealing components are used to seal the two openings of the cylinder, and the end-sealing components are provided with flow ports;
[0007] A fiber bundle assembly, comprising a hollow fiber bundle and connecting rings, wherein the hollow fiber bundle is housed in the receiving cavity, and two connecting rings are respectively disposed at both ends of the hollow fiber bundle, and the ends of the hollow fiber bundle are connected to the connecting rings through a cured adhesive layer, the connecting rings being detachably connected to the interior of the end-sealing member, and the connecting rings isolating the cured adhesive layer from the end-sealing member.
[0008] Furthermore, the connecting ring is embedded inside the end-sealing member, and the outer wall of the connecting ring is tightly fitted with the inner wall of the end-sealing member.
[0009] Furthermore, the roughness Ra of the outer wall of the connecting ring is ≤0.8 μm, and the roughness Ra of the inner wall of the sealing member that is in close contact with the connecting ring is <3.2 μm.
[0010] Furthermore, the outer wall of the connecting ring is a conical ring structure, the conical ring structure having a first conical opening and a second conical opening, the first conical opening being the end closer to the cylinder, the second conical opening being the end away from the cylinder, and the diameter of the first conical opening being smaller than the diameter of the second conical opening;
[0011] The inner wall of the end cap is provided with a tapered groove corresponding to the tapered annular structure.
[0012] Furthermore, the slope of the conical annular structure is 5.88:100 to 6.12:100, and the slope of the conical groove is 5.88:100 to 6.12:100.
[0013] Furthermore, the end-sealing component includes an end head and an end cap, the end head being located between the cylinder and the end cap, one end of the end head being threadedly connected to the cylinder, and the other end of the end head being threadedly connected to the end cap;
[0014] The connecting ring is embedded inside the end head, and the connecting ring is located at the end of the end head near the end cap.
[0015] Furthermore, a first sealing ring is provided between the end and the cylinder, and a second sealing ring is provided between the end and the end cap.
[0016] Furthermore, the end cap is provided with a first flow port, the end head is provided with a second flow port, the second flow port is detachably connected to a flow connector, and a third sealing ring is provided between the flow connector and the end head.
[0017] Furthermore, the blood purification device is a hemodialyzer or a plasma separator.
[0018] Furthermore, the hollow fiber bundle includes multiple hollow fiber tubes. In the hemodialyzer, the inner diameter of the hollow fiber tube is 150 μm to 250 μm, and the pore size on the sidewall is 3 nm to 10 nm. In the plasma separator, the inner diameter of the hollow fiber tube is 200 μm to 400 μm, and the pore size on the sidewall is 200 nm to 600 nm.
[0019] The blood purification device of this invention features a connecting ring on the fiber bundle assembly. The end of the hollow fiber bundle is connected to the connecting ring via a cured adhesive layer. The connecting ring is detachably connected to the inside of the end-sealing component. The connecting ring isolates the cured adhesive layer from the end-sealing component, preventing the hollow fiber bundle from sticking to the end-sealing component due to contact between the cured adhesive layer and the end-sealing component, thus ensuring effective separation. After use, the hollow fiber bundle assembly and end-sealing component can be effectively separated by removing the connecting ring from the end-sealing component. The fiber bundle assembly can be replaced separately, while the end-sealing component and cylinder can be reused after undergoing cleaning, disinfection, and quality inspection processes that meet medical and hygiene requirements. This significantly reduces the manufacturing cost of the blood purification device. Furthermore, the blood purification device provided in this embodiment has low requirements for manufacturing processes, is easy to mass-produce, and has significant potential for widespread application. Attached Figure Description
[0020] Figure 1 This is an exploded structural diagram of the blood purification device provided in the embodiments of this utility model;
[0021] Figure 2 This is a front view of the blood purification device provided in the embodiments of this utility model;
[0022] Figure 3 This is a cross-sectional structural diagram of the hollow fiber tube provided in the embodiment of this utility model. Detailed Implementation
[0023] In related technologies, hollow fiber bundles are usually encapsulated at the end of the blood purification device using colloid, and the hollow fiber bundles and the cylinder are bonded together. The hollow fiber bundles become contaminated after use, and the blood purification device can only be used as a single item. The entire blood purification device needs to be replaced after use, which leads to high costs for blood purification devices and increases the overall cost of blood purification.
[0024] While some technologies allow for the separate installation of hollow fiber bundles within the cylinder, enabling individual replacement, the manufacturing process of blood purification devices necessitates the injection of medical-grade polyurethane adhesives or other sealing materials between the ends of the hollow fiber bundles and the cylinder after placement within the cylinder. This process forms a robust sealing layer, ensuring a strong bond and airtight seal between the hollow fiber bundles and the cylinder, preventing dialysate leakage, and guaranteeing the safety and effectiveness of the blood purification process. However, these existing technologies do not adequately consider the injection process. After injection, the hollow fiber bundles adhere to the inner wall of the cylinder, making separation during subsequent recycling impossible.
[0025] To address the shortcomings of related technologies, this utility model provides a blood purification device that can effectively separate the hollow fiber bundle and the cylinder, thereby allowing the hollow fiber bundle to be replaced and reducing the manufacturing cost of the blood purification device.
[0026] The technical solution of this utility model will be clearly and thoroughly described below with reference to the accompanying drawings. In the description of this utility model, it should be noted that the terms "center," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," and "outer," etc., indicating the orientation or positional relationship shown in the accompanying drawings, are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model. Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Thus, features defined with "first" and "second" may explicitly or implicitly include one or more of the stated features. Moreover, in the description of this utility model, "at least one" means one or more, unless otherwise explicitly specified.
[0027] In this specification, the term "as an alternative embodiment" means that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one alternative embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same implementation or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.
[0028] Combination Figure 1 and Figure 2 As shown, a first aspect of this embodiment provides a blood purification device, including: a cylindrical body 10, an end-sealing member 20, and a fiber bundle assembly, wherein:
[0029] The cylinder 10 is provided with a receiving cavity 11, and the receiving cavity 11 has openings at both ends;
[0030] Two end caps 20 are detachably connected to both ends of the cylinder 10. The two end caps 20 are used to seal the two openings of the cylinder 10 respectively, and the end caps 20 are provided with flow ports.
[0031] The fiber bundle assembly includes a hollow fiber bundle and connecting rings 30. The hollow fiber bundle is housed in the receiving cavity 11. Two connecting rings 30 are respectively disposed at both ends of the hollow fiber bundle (not shown in the figure). The ends of the hollow fiber bundle are connected to the connecting rings 30 through a cured adhesive layer. The connecting rings 30 are detachably connected to the interior of the end cap 20, and the connecting rings 30 isolate the cured adhesive layer from the end cap 20.
[0032] The blood purification device provided in this embodiment features a connecting ring on the fiber bundle assembly. The end of the hollow fiber bundle is connected to the connecting ring via a cured adhesive layer. The connecting ring is detachably connected to the inside of the end-sealing component. The connecting ring isolates the cured adhesive layer from the end-sealing component, preventing the hollow fiber bundle from sticking to the end-sealing component due to contact between the cured adhesive layer and the end-sealing component, thus ensuring effective separation of the hollow fiber bundle and the end-sealing component. After use, the hollow fiber bundle in this embodiment can be effectively separated from the end-sealing component by removing the connecting ring from the inside of the end-sealing component. The fiber bundle assembly can be replaced separately, while the end-sealing component and the cylinder can be reused after undergoing cleaning, disinfection, and quality inspection processes that meet medical and hygiene requirements. This significantly reduces the manufacturing cost of the blood purification device. Furthermore, the blood purification device provided in this embodiment has low requirements for manufacturing process level, is easy to mass-produce, and has great potential for widespread application.
[0033] Based on the above embodiments, as an optional implementation, the connecting ring 30 is embedded inside the sealing member 20, and the outer wall of the connecting ring 30 is tightly fitted with the inner wall of the sealing member 20. This allows the connecting ring 30 to be detachably connected to the sealing member 20 while ensuring a tight seal between them. The connecting ring 30 is a full-circumference annular retaining ring, meaning it has a complete annular structure without notches, grooves, or holes. This isolates the cured adhesive layer from the sealing member 20, preventing liquid adhesive from flowing into the gap between the outer wall of the connecting ring 30 and the inner wall of the sealing member 20 during the curing process, thus ensuring adhesion between them. Alternatively, the connecting ring 30 can be a plastic connecting ring made of injection-molded materials such as polypropylene (PP) or polyvinyl chloride (PVC).
[0034] Based on the above embodiments, as an optional implementation, the outer wall of the connecting ring 30 is a conical ring structure. The conical ring structure has a first conical opening 31 and a second conical opening 32. The first conical opening 31 is the end close to the cylinder 10, and the second conical opening 32 is the end away from the cylinder 10. The diameter of the first conical opening 31 is smaller than the diameter of the second conical opening 32. That is, the diameter of the outer wall of the connecting ring 30 gradually decreases from the end away from the cylinder 10 to the end close to the cylinder 10. The inner wall of the sealing member 20 is provided with a conical groove corresponding to the conical ring structure. Therefore, by setting the outer wall of the connecting ring 30 as a conical annular structure and setting the inner wall of the end cap 20 with a conical groove corresponding to the conical annular structure, the connecting ring 30 can be embedded inside the end cap 20 through a wedge-shaped fit. This not only achieves a tight connection between the connecting ring 30 and the end cap 20, making the connection between the connecting ring 30 and the end cap 20 more secure and stable, but also limits the position of the connecting ring 30, preventing the connecting ring 30 from moving towards the cylinder 10 inside the end cap 20, thus affecting the stability and reliability of the fiber bundle assembly.
[0035] Based on the above embodiments, as an optional implementation, the slope of the conical annular structure is between 5.88:100 and 6.12:100, and the slope of the conical groove is between 5.88:100 and 6.12:100. Preferably, the slope of the conical annular structure is 6:100, and the slope of the conical groove is 6:100. Thus, by setting the slopes of the conical annular structure and the conical groove within the above ranges, it is possible to ensure that the connecting ring 30 can be smoothly inserted into the end-sealing member 20 during installation, and to facilitate separation of the connecting ring 30 and the end-sealing member 20 during disassembly. Simultaneously, the slopes within the above ranges provide a good sealing effect between the connecting ring 30 and the end-sealing member 20, effectively preventing leakage.
[0036] It is understandable that the slope of the conical annular structure being 5.88:100 to 6.12:100 means that the diameter of the conical annular structure differs by 5.88 to 6.12 units for every 100 units of length along the axial direction of the conical annular structure. Similarly, the slope of the conical groove being 5.88:100 to 6.12:100 means that the diameter of the conical groove differs by 5.88 to 6.12 units for every 100 units of length along the axial direction of the end cap 20.
[0037] Based on the above embodiments, as an optional implementation, the roughness Ra of the outer wall of the connecting ring 30 is ≤0.8 μm, and the roughness Ra of the inner wall of the sealing member 20, which is in close contact with the connecting ring 30, is <3.2 μm. Therefore, with the roughness of the outer wall of the connecting ring 30 and the roughness of the inner wall of the sealing member 20 within the above ranges, it can be ensured that the outer wall of the connecting ring 30 and the inner wall of the sealing member 20 remain in close contact. In this embodiment, the roughness Ra of the outer wall of the connecting ring 30 can be ≤0.8 μm by mirror polishing, and the roughness Ra of the inner wall of the sealing member 20, which is in close contact with the connecting ring 30, can be ≤3.2 μm by mirror polishing.
[0038] Based on the above embodiments, as an optional implementation, the end-sealing component 20 includes an end head 21 and an end cap 22. The end head 21 is located between the cylinder 10 and the end cap 22. One end of the end head 21 is threadedly connected to the cylinder 10, and the other end of the end head 21 is threadedly connected to the end cap 22. Therefore, by providing the end head 21 between the cylinder 10 and the end cap 22, the end-sealing component 20 can be divided into two parts, facilitating internal cleaning of the end-sealing component 20 and improving the safety of its recycling. The threaded connection between the end head 21 and the cylinder 10 facilitates disassembly of the end head 21 and the cylinder 10, making cleaning of both parts easier. Similarly, the threaded connection between the end head 21 and the end cap 22 facilitates disassembly of the end head 21 and the end cap 22, making cleaning of both parts easier.
[0039] As an optional implementation, the end 21 and the cylinder 10 are connected by a coarse thread with a pitch ≥ 1 mm, and the end 21 and the end cap 22 are connected by a coarse thread with a pitch ≥ 1 mm. The coarse thread can be a metric coarse thread M series.
[0040] Based on the above embodiments, as an optional implementation, the connecting ring 30 is embedded inside the end 21, and the connecting ring 30 is located at the end of the end 21 near the end cap 22. This allows the end cap 22 to surround the end of the hollow fiber bundle, facilitating contact between the blood and the hollow fiber bundle.
[0041] Based on the above embodiments, as an optional implementation, the axes of the cylinder 10, end 21, end cap 22, and connecting ring 30 coincide. This improves the assembly accuracy of the cylinder 10, end 21, end cap 22, and connecting ring 30 during secondary use.
[0042] Based on the above embodiments, as an optional implementation, the end cap 21 can be a metal end cap made of a metal material that is not easily oxidized, such as stainless steel 316L or titanium alloy, or a plastic end cap made of injection-molded material that meets medical use conditions, such as polycarbonate (PC), polypropylene (PP), polyvinyl chloride (PVC), or polyethylene (PE). The end cap 22 can be a plastic end cap made of injection-molded material such as polycarbonate (PC), polypropylene (PP), polyethylene (PE), or polyvinyl chloride (PVC). The cylinder 10 can be a plastic cylinder made of injection-molded material such as polycarbonate (PC), polypropylene (PP), or polyvinyl chloride (PVC).
[0043] Based on the above embodiments, as an optional implementation, a first sealing ring 23 is provided between the end 21 and the cylinder 10, with one end of the first sealing ring 23 abutting against the end 21 and the other end of the first sealing ring 23 abutting against the cylinder 10; a second sealing ring 24 is provided between the end 21 and the end cap 22, with one end of the second sealing ring 24 abutting against the end 21 and the other end of the second sealing ring 24 abutting against the end cap 22. Thus, by providing the first sealing ring 23 between the end 21 and the cylinder 10, and the second sealing ring 24 between the end 21 and the end cap 22, the sealing performance between the end 21 and the cylinder 10, and between the end 21 and the end cap 22, can be strengthened, preventing liquid leakage. As an optional implementation, the first sealing ring 23 can be a silicone rubber sealing ring or a fluororubber sealing ring, and the second sealing ring 24 can be a silicone rubber sealing ring or a fluororubber sealing ring. Of course, the first sealing ring 23 and the second sealing ring 24 can also be made of other flexible materials.
[0044] Based on the above embodiments, as an optional implementation, a first flow port 221 is provided on the end cap 22. The first flow port 221 can be located in the center of the end cap 22. The first flow port 221 is used for blood inlet or blood outlet. Specifically, the first flow port 221 on one end cap 22 is used for blood inlet, and the first flow port 221 on the other end cap 22 is used for blood outlet. A second flow port 211 is provided on the end head 21. The second flow port 211 can be located on the side of the end head 21. When the blood purification device is a hemodialysis machine, the second flow port 211 is used for dialysate inlet or dialysate outlet. Specifically, the second flow port 211 on one end head 21 of the two end caps 22 is used for dialysate inlet, and the second flow port 211 on the other end head 21 is used for dialysate inlet. When the blood purification device is a plasma separator, the second flow port 211 is used for plasma outlet or sealing port (or pressure detection point). Specifically, the second flow port 211 on one end 21 of the two end caps 22 is used for plasma outlet, while the second flow port 211 on the other end 21 is used for sealing port or pressure detection point.
[0045] Based on the above embodiments, as an optional implementation, the second flow port 211 is detachably connected to a flow connector 212, and a third sealing ring 213 is provided between the flow connector 212 and the end 21. Specifically, the second flow port 211 and the flow connector 212 are connected by threads, one end of the third sealing ring 213 abuts against the end 21, and the other end of the third sealing ring 213 abuts against the flow connector 212. Therefore, by detachably providing the flow connector 212 in the second flow port 211, compared to an integrated structure (i.e., the flow connector 212 and the second flow port 211 are integrally connected), it is not only convenient to disassemble and clean the flow connector 212 and the end 21, but also, if either the end 21 or the flow connector 212 has a quality problem, only the component with the quality problem needs to be replaced, which helps to improve the recycling rate and further reduce production costs. The third sealing ring 213 provided between the flow connector 212 and the end 21 can enhance the sealing between the flow connector 212 and the end 21, preventing liquid leakage. As an optional implementation, the flow connector 212 can be a dialysis nozzle. The dialysis nozzle can be a metal dialysis nozzle made of a non-oxidizing metal material such as 316L stainless steel or titanium alloy, or a plastic dialysis nozzle made of injection-molded materials that meet medical use requirements, such as polycarbonate (PC), polypropylene (PP), polyvinyl chloride (PVC), or polyethylene (PE). The third sealing ring 213 can be a silicone rubber sealing ring or a fluororubber sealing ring. Of course, the third sealing ring 213 can also be made of other flexible materials.
[0046] Based on the above embodiments, as an optional implementation, the second flow port 211 and the flow connector 212 are connected by a coarse thread with a pitch ≥1mm. The coarse thread can be a metric coarse thread M series.
[0047] Based on the above embodiments, as an optional implementation, the blood purification device is a hemodialyzer or a plasma separator. The hollow fiber bundle in this blood purification device includes multiple hollow fiber tubes 40, both ends of which are connected to connecting rings 30 via a cured adhesive layer. Specifically, an adhesive can be applied to both ends of the multiple hollow fiber tubes 40 using a potting method. The adhesive connects both ends of the multiple hollow fiber tubes 40 to two connecting rings 30 respectively. After the adhesive cures, a cured adhesive layer is formed between the ends of the multiple hollow fiber tubes 40 and the connecting rings 30.
[0048] Based on the above embodiments, as an optional implementation method, combined with Figure 3As shown, the hollow fiber tube 40 includes an inner wall 41 and an outer wall 42. The inner diameter of the hollow fiber tube 40 is R1. A sidewall is formed between the inner wall 41 and the outer wall 42, and the sidewall has multiple small holes 43. These small holes 43 are used to filter molecular substances. If the blood purification device is a hemodialysis machine, the inner diameter R1 of the hollow fiber tube 40 in the hemodialysis machine is 150um to 250um, and the pore size of the small holes 43 on the sidewall is 3nm to 10nm. In this case, the hollow fiber tube 40 is mainly composed of a fiber membrane. The pore size of the small holes 43 on the sidewall of the fiber membrane is relatively small. The small holes 43 can allow water, small molecule solutes and some medium molecule solutes to pass through, while preventing large molecules in the blood, such as proteins and blood cells, from passing through, so as to achieve the purpose of better blood purification. If the blood purification device is a plasma separator, then the inner diameter R1 of the hollow fiber tube 40 in the plasma separator is 200µm to 400µm, and the pore size 43 on the sidewall is 200nm to 600nm. In this case, the pore size 43 on the sidewall of the membrane constituting the hollow fiber tube 40 is relatively large, allowing various components in the plasma, including proteins, electrolytes, and metabolic waste, to pass through, while blocking formed elements such as blood cells from the outside of the membrane, thus achieving better separation of plasma and blood cells. It is understood that the pore sizes on the sidewall pores 43 can be the same or different, but the pore sizes of the pores 43 are all within the corresponding pore size range.
[0049] After use, the blood purification device provided in this embodiment is operated by unscrewing the end caps 22 at both ends of the cylinder 10, removing the connecting ring 30 from the inside of the end head 21, separating the connecting ring 30 from the end head 21, stretching the connecting ring 30 outwards to lengthen the hollow fiber bundle fixed to the connecting ring 30, then cutting the exposed hollow fiber bundle with special scissors, and then removing and discarding the cut hollow fiber bundle and the connecting ring 30 fixed to the hollow fiber bundle with a round bar or other tools. The end head 21, the flow connector 212, and the cylinder 10 are then disassembled into individual components. These individual components are then cleaned, disinfected, and dried sequentially. After quality inspection confirms that they meet the quality requirements for recycling, they can be used in secondary production. The blood purification device provided in this embodiment can significantly reduce the manufacturing cost of blood purification devices.
[0050] Although the disclosure is as stated above, the scope of protection of this disclosure is not limited thereto. Those skilled in the art can make various changes and modifications without departing from the spirit and scope of this disclosure, and all such changes and modifications will fall within the protection scope of this utility model.
Claims
1. A blood purification device, characterized in that, include: A cylindrical body, wherein the cylindrical body is provided with a receiving cavity, and the receiving cavity has openings at both ends; Two end-sealing components are detachably connected to both ends of the cylinder, and the two end-sealing components are used to seal the two openings of the cylinder, and the end-sealing components are provided with flow ports; A fiber bundle assembly, comprising a hollow fiber bundle and connecting rings, wherein the hollow fiber bundle is housed in the receiving cavity, and two connecting rings are respectively disposed at both ends of the hollow fiber bundle, and the ends of the hollow fiber bundle are connected to the connecting rings through a cured adhesive layer, the connecting rings being detachably connected to the interior of the end-sealing member, and the connecting rings isolating the cured adhesive layer from the end-sealing member.
2. The blood purification device according to claim 1, characterized in that, The connecting ring is embedded inside the end cap, and the outer wall of the connecting ring is in close contact with the inner wall of the end cap.
3. The blood purification device according to claim 2, characterized in that, The roughness Ra of the outer wall of the connecting ring is ≤0.8 μm, and the roughness Ra of the inner wall of the sealing member that is in close contact with the connecting ring is <3.2 μm.
4. The blood purification device according to claim 2, characterized in that, The outer wall of the connecting ring is a conical ring structure, which has a first conical opening and a second conical opening. The first conical opening is at the end close to the cylinder, and the second conical opening is at the end away from the cylinder. The diameter of the first conical opening is smaller than the diameter of the second conical opening. The inner wall of the end cap is provided with a tapered groove corresponding to the tapered annular structure.
5. The blood purification device according to claim 4, characterized in that, The slope of the conical annular structure is 5.88:100 to 6.12:100, and the slope of the conical groove is 5.88:100 to 6.12:
100.
6. The blood purification device according to claim 1, characterized in that, The end cap includes an end head and an end cap. The end head is located between the cylinder and the end cap. One end of the end head is threadedly connected to the cylinder, and the other end of the end head is threadedly connected to the end cap. The connecting ring is embedded inside the end head, and the connecting ring is located at the end of the end head near the end cap.
7. The blood purification device according to claim 6, characterized in that, A first sealing ring is provided between the end and the cylinder, and a second sealing ring is provided between the end and the end cap.
8. The blood purification device according to claim 6, characterized in that, The end cap is provided with a first flow port, and the end head is provided with a second flow port. The second flow port is detachably connected to a flow connector, and a third sealing ring is provided between the flow connector and the end head.
9. The blood purification device according to claim 1, characterized in that, The blood purification device is a hemodialyzer or a plasma separator.
10. The blood purification device according to claim 9, characterized in that, The hollow fiber bundle includes multiple hollow fiber tubes. In the hemodialyzer, the inner diameter of the hollow fiber tube is 150 μm to 250 μm, and the pore size on the sidewall is 3 nm to 10 nm. In the plasma separator, the inner diameter of the hollow fiber tube is 200 μm to 400 μm, and the pore size on the sidewall is 200 nm to 600 nm.