Modular temperature control structure for a nucleic acid synthesizer

Abstract

The utility model relates to nucleic acid synthesizer temperature control technical field discloses a modularization temperature control structure of nucleic acid synthesizer, including synthetic column body, the outer wall left and right sides of synthetic column body are installed with female temperature control shell and male temperature control shell respectively, the outer wall of female temperature control shell is set up with a plurality of mounting holes, the inner wall of male temperature control shell is connected with a plurality of sliding long rod symmetrically, the outer wall of sliding long rod is fixedly connected with a plurality of press button and sliding block, the outer wall of sliding block is fixedly connected with the engagement block, the inner wall of male temperature control shell is provided with a plurality of spring no.

Description

Technical Field

[0001] This utility model relates to the field of temperature control technology for nucleic acid synthesizers, and in particular to a modular temperature control structure for a nucleic acid synthesizer. Background Technology

[0002] Artificial nucleic acid synthesis is the only known method for targeted modification of gene sequences, and it is widely used in many fields such as protein modification and life sciences, including nucleic acid drugs, enzyme engineering, gene detection, and gene therapy. Nucleic acid synthesizers are important equipment in the field of biotechnology, widely used for the synthesis of DNA and RNA. During synthesis, various reaction reagents are sequentially injected into a synthesis column to react with the carrier within the column.

[0003] In existing technologies, nucleic acid synthesizers typically employ a single temperature control system, which regulates temperature by heating or cooling the entire synthesis column. However, RNA synthesis is highly sensitive to temperature. This method of heating the entire synthesis column cannot provide differentiated temperature control for different regions of the column, resulting in multiple temperature zones within the synthesis column during RNA synthesis. This uneven temperature distribution can lead to localized excessively high or low temperatures, affecting the stability of RNA synthesis and the purity of the product. Utility Model Content

[0004] To overcome the above shortcomings, this invention provides a modular temperature control structure for a nucleic acid synthesizer, aiming to improve the existing nucleic acid synthesis process, which heats the entire synthesis column and cannot differentiate the temperature control for different regions of the synthesis column, thus affecting the stability of RNA synthesis and the purity of the product.

[0005] To achieve the above objectives, this utility model provides the following technical solution: a modular temperature control structure for a nucleic acid synthesizer, comprising a synthesis column body, wherein a female temperature control shell and a male temperature control shell are respectively installed on the left and right sides of the outer wall of the synthesis column body, the outer wall of the female temperature control shell has multiple mounting holes, the inner wall of the male temperature control shell has multiple sliding rods symmetrically slidably connected, the outer wall of the sliding rods has multiple push buttons and sliders fixedly connected, the outer wall of the sliders has a locking block fixedly connected, the inner wall of the male temperature control shell has multiple springs symmetrically arranged, and the bottom of the synthesis column body is provided with a fixing component.

[0006] The above technical solution utilizes the male and female temperature control shells to form a tight external fit on the outer wall of the synthesis column, enabling regional individual adjustment and control of the synthesis column temperature during the synthesis process. By pressing the button on the male temperature control shell, the sliding rod is driven to compress the spring, which in turn drives the slider and locking block to slide and form a locking connection with the mounting hole on the female temperature control shell, thereby firmly fixing the temperature control structure to the outer wall of the synthesis column.

[0007] As a further description of the above technical solution:

[0008] Preferably, the fixing component includes a base, which is fixedly connected to the bottom end of the composite column body. A rotating seat is rotatably connected to the bottom end of the base. An inner core is fixedly connected to the bottom end of the rotating seat. A snap ring is provided on the outer wall of the inner core. A limit toothed sleeve is slidably connected to the bottom end of the rotating seat. A telescopic rod is fixedly connected to the outer wall of the rotating seat. An abutment block is fixedly connected to one end of the telescopic rod. A sliding rod is slidably connected to the inner wall of the abutment block. A fixing block and a clamping block are fixedly connected to the outer wall of the sliding rod. A spring is sleeved on the outer wall of the sliding rod.

[0009] The above technical solution involves installing an additional rotating seat at the bottom of the synthetic column base, and setting an angle self-locking structure at the bottom of the rotating seat to allow for free adjustment of the rotating seat's angle. This facilitates the fixing device to form a perpendicular relationship with the edge of the table. Then, the distance is adjusted using a telescopic rod, and the distance between the abutment block and the clamping block is adjusted using a compression spring, making it easy to fix the device on the table.

[0010] As a further description of the above technical solution:

[0011] Preferably, the outer walls of both the female and male temperature control shells are equipped with multiple temperature sensors and heating elements, the outer side of the synthesis column body is provided with multiple connecting rods, the outer walls of both the female and male temperature control shells are provided with multiple positioning grooves, and the outer walls of the connecting rods are slidably connected to the inner walls of the positioning grooves.

[0012] The above technical solution involves uniformly arranging multiple temperature sensors and heating elements along the axial direction on the inner and outer walls of the male and female temperature control shells to form regional divisions. After being attached to the outer wall of the synthesis column, the internal temperature is detected in sections, and the temperature is adjusted by opening and closing the heating elements. The positioning groove on the temperature control shell is used to form a snap-fit ​​with the original connecting rod on the synthesis column, which facilitates user positioning and ensures temperature control quality.

[0013] As a further description of the above technical solution:

[0014] Preferably, the inner wall of the male temperature control shell is provided with multiple sliding grooves, the outer wall of the sliding rod is slidably connected to the inner wall of the sliding groove, the outer wall of the male temperature control shell is provided with and penetrates multiple limiting grooves, the outer walls of the push button and the slider are slidably connected to the inner wall of the limiting groove, the locking block and the mounting hole are adapted to each other, and the outer wall of the locking block is engaged with the inner wall of the mounting hole.

[0015] The above technical solution limits the sliding of the sliding rod, the push button, and the slider by opening the sliding groove and the limiting groove, ensuring the stability of their sliding. This allows the locking block to be stably locked in the mounting hole, completing the tight installation and fit of the temperature control structure.

[0016] As a further description of the above technical solution:

[0017] Preferably, one end of the spring is fixedly connected to the inner wall of the temperature control shell, and the other end of the spring is fixedly connected to the outer wall of the sliding rod.

[0018] The above technical solution uses a spring to connect the sliding rod to the inner wall of the temperature control housing. When the sliding rod is pressed and slid, it compresses the spring. When released, the stress of the spring causes the sliding rod to slide backward, so that the locking block engages with the inner wall of the mounting hole.

[0019] As a further description of the above technical solution:

[0020] Preferably, a limiting ring is fixedly connected to the outer wall of the rotating seat, a rotating groove is formed on the inner wall of the base, the limiting ring is slidably connected to the inner wall of the rotating groove, and the lower surface of the rotating seat and the upper surface of the limiting tooth sleeve are slidably connected to each other.

[0021] The above technical solution ensures stable rotation of the rotating seat by means of the locking ring at the top of the rotating seat and the rotating groove on the inner wall of the base, without affecting the stability of the base and the locking sleeve.

[0022] As a further description of the above technical solution:

[0023] Preferably, the outer wall of the inner core is provided with multiple pushing grooves, the snap ring is installed in the pushing grooves, the inner wall of the limiting tooth sleeve is provided with annular teeth, and the outer wall of the snap ring is snapped into the inner wall of the annular teeth.

[0024] The above technical solution involves connecting the snap ring and the inner core by pushing the gap in the groove. When the inner core is rotated by the rotating seat, it can further drive the snap ring to rotate synchronously. The ring teeth of the limiting tooth sleeve can engage the snap ring in real time, thereby forming a certain angle self-locking.

[0025] As a further description of the above technical solution:

[0026] Preferably, one end of the second spring is fixedly connected to the outer wall of the fixing block, and the other end of the second spring is fixedly connected to the outer wall of the abutment block. The outer wall of the clamping block has a working groove that extends through it, and the bottom end of the abutment block is slidably connected to the inner wall of the working groove.

[0027] The above technical solution involves pressing down on the clamping block to compress the second spring, thereby adjusting the distance between the clamping block and the fixing block to accommodate different tabletop thicknesses. The elasticity of the second spring is used to clamp the upper and lower surfaces of the tabletop.

[0028] This utility model has the following beneficial effects:

[0029] 1. In this utility model, two semi-circular temperature control shells are installed on the outer wall of the synthesis column to adhere to the surface of the synthesis column. Temperature sensors and heating elements installed in sections on the outside of the temperature control shells are used to independently control and adjust the temperature of different areas of the synthesis column, thereby ensuring the stability of nucleic acid synthesis and the purity of the product.

[0030] 2. In this utility model, by installing a fixing structure that can be freely adjusted in angle and self-locking in real time under the base of the synthesis column, the synthesis column can be clamped and fixedly connected with the tabletop edge during the synthesis process, reducing the impact of accidental external contact on the synthesis column. Attached Figure Description

[0031] Figure 1 This is a front view of a modular temperature control structure for a nucleic acid synthesizer proposed in this utility model;

[0032] Figure 2 This is a schematic diagram showing the unfolded modular temperature control structure of a nucleic acid synthesizer proposed in this utility model;

[0033] Figure 3 This is a separate schematic diagram of the temperature control shell of a modular temperature control structure for a nucleic acid synthesizer proposed in this utility model;

[0034] Figure 4 This is a cross-sectional view of the temperature control shell of a modular temperature control structure for a nucleic acid synthesizer proposed in this utility model;

[0035] Figure 5 This is a bottom view of the modular temperature control structure of a nucleic acid synthesizer proposed in this utility model;

[0036] Figure 6 This is a schematic diagram of the fixed components of a modular temperature control structure for a nucleic acid synthesizer proposed in this utility model;

[0037] Figure 7 This is a structural breakdown diagram of the angle self-locking unit of the modular temperature control structure of a nucleic acid synthesizer proposed in this utility model.

[0038] Legend:

[0039] 1. Synthesis column body; 2. Female temperature control shell; 3. Male temperature control shell; 4. Temperature sensor; 5. Heating element; 6. Press button; 7. Sliding rod; 8. Slider; 9. Locking block; 10. Spring 1; 11. Mounting hole; 12. Connecting rod; 13. Positioning groove; 14. Fixing assembly; 1401. Base; 1402. Rotating seat; 1403. Limiting ring; 1404. Inner core; 1405. Locking ring; 1406. Limiting tooth sleeve; 1407. Telescopic rod; 1408. Abutment block; 1409. Sliding rod; 1410. Fixing block; 1411. Spring 2; 1412. Clamping block. Detailed Implementation

[0040] The technical solutions of the embodiments of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this utility model, and not all embodiments. Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of this utility model.

[0041] Reference Figure 1 , Figure 2 and Figure 4 This utility model provides an embodiment of a modular temperature control structure for a nucleic acid synthesizer, comprising a synthesis column body 1. A female temperature control shell 2 and a male temperature control shell 3 are respectively installed on the left and right sides of the outer wall of the synthesis column body 1. The outer wall of the female temperature control shell 2 has multiple mounting holes 11. Multiple sliding rods 7 are symmetrically slidably connected to the inner wall of the male temperature control shell 3. Multiple pressing buttons 6 and sliders 8 are fixedly connected to the outer wall of the sliding rods 7. A locking block 9 is fixedly connected to the outer wall of the slider 8. Multiple springs 10 are symmetrically arranged on the inner wall of the male temperature control shell 3. The bottom of the column body 1 is provided with a fixing component 14. The inner wall of the male temperature control shell 3 is provided with multiple sliding grooves. The outer wall of the sliding rod 7 is slidably connected to the inner wall of the sliding groove. The outer wall of the male temperature control shell 3 is provided with multiple limiting grooves. The outer walls of the pressing button 6 and the slider 8 are slidably connected to the inner wall of the limiting groove. The locking block 9 and the mounting hole 11 are adapted to each other. The outer wall of the locking block 9 is locked into the inner wall of the mounting hole 11. One end of the spring 10 is fixedly connected to the inner wall of the male temperature control shell 3, and the other end of the spring 10 is fixedly connected to the outer wall of the sliding rod 7.

[0042] Specifically, the synthesis column body 1 is connected to the synthesizer and contains the raw materials required for synthesis. Nucleic acid synthesis is performed according to the synthesizer's set program. The external temperature control shell 2 and male temperature control shell 3 are attached and installed to detect and adjust the temperature of the outer wall of the synthesis column body 1. Both the female temperature control shell 2 and male temperature control shell 3 are semi-circular structures. After being connected, they are tightly attached to the glass outer surface of the synthesis column body 1. The internal raw materials of the synthesis column body 1 are temperature controlled and adjusted in stages. By pressing the buttons 6 on both sides of the male temperature control shell 3 at the same time, when it slides inward, it drives the internal sliding rod 7 to compress the spring 10. The sliding rod 7 drives the slider 8 and the locking block 9 to slide, so that the locking block 9 locks into the inner wall of the mounting hole 11 opened on the female temperature control shell 2. After releasing, the elasticity of the spring 10 can drive the locking block 9 to slide back and firmly lock into the inner wall of the mounting hole 11, thus completing the mutual splicing and installation of the female temperature control shell 2 and male temperature control shell 3.

[0043] Reference Figure 2 , Figure 5 and Figure 6 The fixing component 14 includes a base 1401, which is fixedly connected to the bottom end of the composite column body 1. A rotating seat 1402 is rotatably connected to the bottom end of the base 1401. An inner core 1404 is fixedly connected to the bottom end of the rotating seat 1402. A snap ring 1405 is provided on the outer wall of the inner core 1404. A limit toothed sleeve 1406 is slidably connected to the bottom end of the rotating seat 1402. A telescopic rod 1407 is fixedly connected to the outer wall of the rotating seat 1402. An abutment block 1408 is fixedly connected to one end of the telescopic rod 1407. A sliding rod 1409 is slidably connected to the inner wall of the abutment block 1408. A fixing block 141 is fixedly connected to the outer wall of the sliding rod 1409. 0 and clamping block 1412, spring 1411 is sleeved on the outer wall of slide rod 1409, limit ring 1403 is fixedly connected to the outer wall of rotating seat 1402, rotating groove is opened on the inner wall of base 1401, limit ring 1403 is slidably connected to the inner wall of rotating groove, the lower surface of rotating seat 1402 and the upper surface of limit tooth sleeve 1406 are slidably connected to each other, one end of spring 1411 is fixedly connected to the outer wall of fixing block 1410, the other end of spring 1411 is fixedly connected to the outer wall of abutment block 1408, a working groove is opened and penetrated on the outer wall of clamping block 1412, and the bottom end of abutment block 1408 is slidably connected to the inner wall of working groove;

[0044] Specifically, the entire fixing assembly 14 is located at the bottom of the synthesis column body 1, facilitating its fixation to the edge of the table during synthesis to prevent vibrations caused by accidental external contact. The entire fixing assembly 14 comprises two parts: an angle rotation unit and a tabletop fixing unit. The tabletop fixing unit is fixedly connected to the outer wall of the rotating seat 1402, which is rotatably connected to the bottom of the synthesis column body 1 via a self-locking structure, facilitating adjustment of the angle of the tabletop fixing unit. The synthesis column body 1 is fixedly connected to the top of the base 1401, and the bottom of the base 1401 is rotatably connected to the rotating seat 1402 via a rotating groove. When the rotating seat 1402 rotates, it is held in place by the inner core 1404 and the retaining ring 1405 at its bottom end. The locking structure formed with the limiting tooth sleeve 1406 is self-locked at a certain angle, so that the desktop fixing unit is perpendicular to the edge of the desktop. Then, the telescopic rod 1407 is stretched so that the desktop fixing unit is located at the edge of the desktop. Then, the fixing block 1410 is pressed down, and while compressing the second spring 1411, the sliding rod 1409 and the clamping block 1412 at the bottom end are driven to descend together, so that the clamping block 1412 and the abutment block 1408 are disengaged from their original locking relationship, forming a certain gap, which makes it easy to insert the tabletop into the gap between them. When released, the elastic force of the second spring 1411 is used to drive the clamping block 1412 to slide upward and in the opposite direction, firmly fixing the tabletop between the abutment block 1408 and the clamping block 1412, thereby completing the fixing of the composite column body 1 to the edge of the desktop.

[0045] Reference Figure 2 , Figure 3 and Figure 4 Multiple temperature sensors 4 and heating elements 5 are installed on the outer walls of both the female temperature control shell 2 and the male temperature control shell 3. Multiple connecting rods 12 are provided on the outside of the synthesis column body 1. Multiple positioning grooves 13 are opened on the outer walls of both the female temperature control shell 2 and the male temperature control shell 3. The outer walls of the connecting rods 12 are slidably connected to the inner walls of the positioning grooves 13.

[0046] Specifically, the synthesis column body 1 is divided into multiple independent temperature control zones along the axial direction, such as the top, middle, bottom, and transition zone. The length of each zone is proportionally divided according to the actual specifications of the synthesis column body 1. Each zone is equipped with an independent temperature sensor 4 and a heating element 5. The temperature sensor 4 detects the zone temperature while the heating element 5 heats it, ensuring more precise control of the key reaction zone. Polytetrafluoroethylene heat insulation rings are set between each temperature control zone to reduce heat conduction between zones. At the same time, the internal components of the female temperature control shell 2 and the male temperature control shell 3 are connected to the synthesizer through MCU chips, etc. According to the set synthesis program, the temperature data of each zone is processed in real time, and the heating element 5 is controlled to open and close via PWM signals to adjust the heating or cooling power. This achieves the effect of differentiated control of the temperature requirements of different zones of the synthesis column body 1. Meanwhile, the positioning grooves 13 on the female temperature control shell 2 and the male temperature control shell 3 engage and slide with the connecting rods 12 on the synthesis column body 1 itself, which facilitates the positioning of the female temperature control shell 2 and the male temperature control shell 3 and provides a certain degree of fixation.

[0047] Reference Figure 7 The outer wall of the inner core 1404 is provided with multiple pushing grooves, the snap ring 1405 is installed in the pushing grooves, the inner wall of the limiting tooth sleeve 1406 is provided with annular teeth, and the outer wall of the snap ring 1405 is snapped into the inner wall of the annular teeth.

[0048] Specifically, the snap ring 1405 is installed in the push groove of the inner core 1404. When the inner core 1404 is manually rotated along with the rotating seat 1402, the snap ring 1405 is pushed to rotate along with it through the push groove. At the same time as the rotation, the protruding outer wall of the snap ring 1405 slides and engages with the inner wall of the ring tooth of the limiting tooth sleeve 1406 in real time, thereby forming a real-time self-locking. This facilitates the rotation and adjustment of the angle, and also plays a certain role in fixing after the adjustment is completed, reducing the impact of accidental contact. This makes it easier to adjust the angle of the components on the telescopic rod 1407 to vertically clamp the edge of the table and fix the composite column body 1.

[0049] Working principle: When using this temperature control structure to regulate the temperature of the nucleic acid synthesis column, align the female temperature control shell 2 and the male temperature control shell 3 from the left and right sides of the synthesis column body 1. Align the positioning groove 13 with the connecting rod 12 on the synthesis column body 1 for positioning, and align the locking block 9 on the male temperature control shell 3 with the mounting hole 11 on the female temperature control shell 2. Simultaneously, press the two pressing buttons 6 on the outer wall of the male temperature control shell 3 inward, causing the internal sliding rod 7 to slide inward and compress the spring. At the same time as spring 10, the sliders 8 and locking blocks 9 on both sides are compressed inward. Then, the locking block 9 is inserted into the mounting hole 11 of the female temperature control shell 2, so that the female temperature control shell 2 and the male temperature control shell 3 are tightly joined. Then, the hand is released, and the stress of spring 10 is used to drive the sliding rod 7, slider 8 and locking block 9 to slide in reverse, so that the locking block 9 is engaged with the inner wall of the mounting hole 11, thereby joining the female temperature control shell 2 and the male temperature control shell 3 together, completely covering the outer wall of the synthesis chamber of the synthesis column body 1.

[0050] Multiple temperature sensors 4 and heating elements 5 are layered at the contact points between the female temperature control shell 2 and the male temperature control shell 3 and the synthesis column body 1, and are connected to the synthesizer. Through a set program, the temperature sensors 4 are used to detect the real-time temperature of each part inside the synthesis column body 1 during the synthesis process, and the heating elements 5 are turned on or off to adjust and control the temperature of each part inside the synthesis column body 1 individually.

[0051] During the synthesis process, to prevent accidental external contact that could cause the synthesis column body 1 to shake or tip over, after placing the synthesis column body 1 on the table, rotate the rotating seat 1402 under the base 1401, causing it to rotate the inner core 1404 fixedly connected at the bottom. The inner core 1404 pushes the locking ring 1405 to rotate synchronously. The outer wall of the locking ring 1405 slides and engages with the toothed inner wall of the limiting tooth sleeve 1406 in real time, forming a real-time self-locking mechanism. This causes the telescopic rod 1407 to adjust its angle, allowing the telescopic rod 1407 to adjust its angle. 07 is perpendicular to the edge of the table. Then, stretch the telescopic rod 1407 to align the abutment block 1408 and clamping block 1412 with the edge of the table. Then, press down on the slide rod 1409, which causes the fixing block 1410 and clamping block 1412 to slide down together while compressing the second spring 1411. This causes the edge of the table to be clamped by the upper surface of the clamping block 1412 and the bottom end of the abutment block 1408. After releasing, the stress of the second spring 1411 is used to continuously apply clamping force, thereby ensuring the stability of the composite column body 1 and reducing the possibility of tilting caused by accidental contact.

[0052] Finally, it should be noted that the above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Although the present utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A modular temperature control structure for a nucleic acid synthesizer, comprising a synthesis column body (1), characterized in that: The outer walls of the synthesis column body (1) are respectively equipped with a female temperature control shell (2) and a male temperature control shell (3). The outer walls of the female temperature control shell (2) are provided with multiple mounting holes (11). The inner walls of the male temperature control shell (3) are symmetrically connected with multiple sliding rods (7). The outer walls of the sliding rods (7) are fixedly connected with multiple push buttons (6) and sliders (8). The outer walls of the sliders (8) are fixedly connected with locking blocks (9). The inner walls of the male temperature control shell (3) are symmetrically provided with multiple springs (10). The bottom of the synthesis column body (1) is provided with a fixing component (14).

2. The modular temperature control structure of a nucleic acid synthesizer according to claim 1, characterized in that: The fixing component (14) includes a base (1401), which is fixedly connected to the bottom end of the composite column body (1). A rotating seat (1402) is rotatably connected to the bottom end of the base (1401). An inner core (1404) is fixedly connected to the bottom end of the rotating seat (1402). A snap ring (1405) is provided on the outer wall of the inner core (1404). A limit toothed sleeve (1) is slidably connected to the bottom end of the rotating seat (1402). 406), the outer wall of the rotating seat (1402) is fixedly connected to a telescopic rod (1407), one end of the telescopic rod (1407) is fixedly connected to an abutment block (1408), the inner wall of the abutment block (1408) is slidably connected to a slide rod (1409), the outer wall of the slide rod (1409) is fixedly connected to a fixing block (1410) and a clamping block (1412), and the outer wall of the slide rod (1409) is sleeved with a spring (1411).

3. The modular temperature control structure of a nucleic acid synthesizer according to claim 1, characterized in that: Multiple temperature sensors (4) and heating elements (5) are installed on the outer walls of the female temperature control shell (2) and the male temperature control shell (3). Multiple connecting rods (12) are provided on the outside of the synthesis column body (1). Multiple positioning grooves (13) are opened on the outer walls of the female temperature control shell (2) and the male temperature control shell (3). The outer walls of the connecting rods (12) are slidably connected to the inner walls of the positioning grooves (13).

4. The modular temperature control structure of a nucleic acid synthesizer according to claim 1, characterized in that: The inner wall of the male temperature control shell (3) is provided with multiple sliding grooves. The outer wall of the sliding rod (7) is slidably connected to the inner wall of the sliding groove. The outer wall of the male temperature control shell (3) is provided with multiple limiting grooves. The outer walls of the pressing button (6) and the slider (8) are slidably connected to the inner wall of the limiting groove. The locking block (9) and the mounting hole (11) are adapted to each other. The outer wall of the locking block (9) is locked into the inner wall of the mounting hole (11).

5. The modular temperature control structure of a nucleic acid synthesizer according to claim 1, characterized in that: One end of the spring (10) is fixedly connected to the inner wall of the temperature control shell (3), and the other end of the spring (10) is fixedly connected to the outer wall of the sliding rod (7).

6. The modular temperature control structure of a nucleic acid synthesizer according to claim 2, characterized in that: The outer wall of the rotating seat (1402) is fixedly connected to a limiting ring (1403), the inner wall of the base (1401) is provided with a rotating groove, the limiting ring (1403) is slidably connected to the inner wall of the rotating groove, and the lower surface of the rotating seat (1402) and the upper surface of the limiting tooth sleeve (1406) are slidably connected to each other.

7. The modular temperature control structure of a nucleic acid synthesizer according to claim 2, characterized in that: The outer wall of the inner core (1404) is provided with multiple pushing grooves, the snap ring (1405) is installed in the pushing grooves, the inner wall of the limiting tooth sleeve (1406) is provided with annular teeth, and the outer wall of the snap ring (1405) snaps into the inner wall of the annular teeth.

8. The modular temperature control structure of a nucleic acid synthesizer according to claim 2, characterized in that: One end of the second spring (1411) is fixedly connected to the outer wall of the fixed block (1410), and the other end of the second spring (1411) is fixedly connected to the outer wall of the abutment block (1408). The outer wall of the clamping block (1412) has a working groove that extends through it, and the bottom end of the abutment block (1408) is slidably connected to the inner wall of the working groove.

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