External temperature control device for lipid nanoparticle preparation

Abstract

The utility model belongs to lipid nanoparticle preparation technical field especially for external temperature control device for lipid nanoparticle preparation, including base plate, is located the top of base plate and is provided with temperature control box, is rotationally connected with the lid on temperature control box, is provided with the heat -proof plate in temperature control box's inside, the top one side of base plate is installed temperature control instrument, is located the heat -proof plate and is provided with the electric heating tube of wire connection with temperature control instrument, through setting up the convenient disassembly formula's hoop pipe board, after the pipe line of lipid nanoparticle preparation ware is clamped solid in hoop pipe board, when needing to clean the pipe body, can integrally dismount hoop pipe board, make it and pipe body all are soaked in cleaning fluid, then use the shower nozzle to spray and wash can, thereby exempts from traditional need one -by -one to dismount the operation of cleaning pipe body, relative traditional temperature control device, this design simplifies the operation step, realizes the purpose of pipe body fast maintenance, improves practicality.

Description

Technical Field

[0001] This invention belongs to the field of lipid nanoparticle preparation technology, specifically relating to an external temperature control device for lipid nanoparticle preparation. Background Technology

[0002] Besides inactivated antigens, a large portion of vaccine drugs are mainly mRNA. Through transcription of mRNA in the human body, target proteins with therapeutic effects are obtained, thereby curing or preventing various diseases.

[0003] During the LNP-mRNA preparation process, the tubing is exposed to room temperature for a long time. However, studies have shown that the mixing process of lipid molecules and mRNA is quite sensitive to temperature. Temperature changes can affect the stability of the particles. Some existing temperature control devices place the tubing of the lipid nanoparticle preparer in the temperature control device. The tubing is fixed by multiple clips and connected to a heat-conducting plate so that the temperature can be adjusted in real time by a temperature controller to achieve a controllable effect.

[0004] However, in practical use, the existing temperature control device requires regular cleaning of the internal tubing of the preparation device. Repeated removal and installation of the tubing over a long period of time will not only cause irreversible wear to the tubing but also affect the elastic potential energy of the buckles on the temperature control device. Furthermore, the lipid nanoparticle preparation device has multiple tubing, which needs to be snapped onto the buckles one by one after cleaning, making the operation quite cumbersome.

[0005] To address the aforementioned issues, this application proposes an external temperature control device for the preparation of lipid nanoparticles. Utility Model Content

[0006] To address the aforementioned problems in the existing technology, this utility model provides an external temperature control device for the preparation of lipid nanoparticles, which features convenient pipeline installation, cleaning, and ease of use.

[0007] To achieve the above objectives, the present invention provides the following technical solution: an external temperature control device for the preparation of lipid nanoparticles, comprising a base plate, a temperature control box located on the top of the base plate, and a box cover rotatably connected to the temperature control box;

[0008] A heat insulation plate is installed inside the temperature control box;

[0009] A temperature controller is installed on one side of the top of the base plate, and an electric heating tube connected to the wires of the temperature controller is provided on the heat insulation plate. Multiple cooling fans connected to the wires of the temperature controller are installed on the box cover.

[0010] The temperature control box is provided with a clamp plate, and multiple equally spaced waveform grooves are opened on the clamp plate. Multiple waveform clamps that match the waveform grooves are also provided on the clamp plate.

[0011] It also includes a fixing mechanism, which is mounted on the base plate via a support plate. The fixing mechanism is connected to the temperature control box and the clamp plate and is used to limit and fix the clamp plate.

[0012] Preferably, two symmetrically distributed fixing blocks are fixed on one side of the inner wall of the temperature control box. The fixing mechanism also includes a connecting rod fixed to the support plate and connected to the temperature control box. A sliding plate is slidably connected to the connecting rod. A symmetrically distributed sliding rod is provided on the side of the sliding plate facing the temperature control box. Movable fixing blocks are provided at the ends of the two sliding rods. The sliding rods are slidably connected to the temperature control box.

[0013] Both the movable snap-fit ​​block and the fixed snap-fit ​​block are provided with snap-fit ​​grooves that are adapted to the clamp plate. A spring is sleeved around the outside of the connecting rod, and the spring is located between the support plate and the sliding plate.

[0014] Preferably, a through-tube groove corresponding to the waveform groove is provided on both sides of the top of the temperature control box.

[0015] Preferably, both the movable latching block and the fixed latching block are provided with beveled surfaces.

[0016] Preferably, heat dissipation holes are provided at equal intervals on both sides of the heat insulation plate, the heat insulation plate is located above the base plate and there is a gap between the heat insulation plate and the base plate.

[0017] Preferably, the base plate has multiple ventilation holes that connect to the temperature control box.

[0018] Preferably, suction cup assemblies are provided at the four corners of the base plate. Each suction cup assembly includes an integrally formed rubber suction cup and a hardened sheet. A screw is provided on the hardened sheet. A circular hole with a diameter larger than the screw is opened on the base plate. A screw cap is screwed onto the screw. The screw cap and the rubber suction cup are respectively located on the upper and lower sides of the base plate.

[0019] Compared with the prior art, the beneficial effects of this utility model are:

[0020] In this invention, by setting a removable clamp plate, the tubing of the lipid nanoparticle preparer is secured to the clamp plate. When the tubing needs to be cleaned, the clamp plate can be completely removed, allowing both the clamp plate and the tubing to be immersed in the cleaning solution. Then, the tubing can be sprayed with a nozzle for cleaning. This eliminates the need for the traditional operation of disassembling and cleaning each tubing individually. Compared with traditional temperature control devices, this design simplifies the operation steps, achieves the purpose of rapid tubing maintenance, and improves practicality.

[0021] Other additional advantages and benefits of this application will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of this application. Attached Figure Description

[0022] The accompanying drawings are provided to further illustrate the present invention and form part of the specification. They are used together with the embodiments of the present invention to explain the present invention, but do not constitute a limitation thereof. In the drawings:

[0023] Figure 1 This is a schematic diagram of the structure of this utility model;

[0024] Figure 2 This is a schematic diagram of the temperature control box after it has been opened.

[0025] Figure 3 for Figure 2 A magnified structural diagram of the A mark in the diagram;

[0026] Figure 4 for Figure 2 The bottom shows a schematic diagram of the structure;

[0027] Figure 5 for Figure 2 Schematic diagram of the structure after the central hoop tube sheet is concealed;

[0028] Figure 6 for Figure 5 A schematic diagram of the enlarged structure of the B mark in the diagram;

[0029] Figure 7 This is a three-dimensional structural diagram of the hoop plate;

[0030] Figure 8 This is a schematic diagram of the overall structure of the suction cup assembly.

[0031] In the diagram: 1. Base plate; 2. Temperature control box; 3. Box cover; 4. Temperature controller; 5. Cooling fan; 6. Suction cup assembly; 7. Support plate; 8. Pipe groove; 9. Hoop plate; 10. Corrugated groove; 11. Corrugated clamping plate; 12. Heat insulation plate; 13. Heat dissipation hole; 14. Sliding plate; 15. Connecting rod; 16. Spring; 17. Slide rod; 18. Movable locking block; 19. Beveled surface; 20. Locking groove; 21. Ventilation hole; 22. Heating element; 23. Fixed locking block; 24. Rubber suction cup; 25. Twisted cap; 26. Hardened sheet; 27. Screw. Detailed Implementation

[0032] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0033] Example

[0034] Please see Figures 1-8 The present invention provides the following technical solution: an external temperature control device for the preparation of lipid nanoparticles, including a base plate 1, a temperature control box 2 located on the top of the base plate 1, and a box cover 3 rotatably connected to the temperature control box 2.

[0035] A heat insulation plate 12 is installed inside the temperature control box 2;

[0036] A temperature controller 4 is installed on one side of the top of the base plate 1. An electric heating tube 22 connected to the wires of the temperature controller 4 is set on the heat insulation plate 12. Multiple cooling fans 5 connected to the wires of the temperature controller 4 are installed on the cover 3. The temperature controller 4 controls the opening or closing of the cooling fans 5 and the electric heating tube 22. The temperature controller 4 is an existing electrical component.

[0037] The temperature control box 2 is provided with a clamp plate 9, and multiple equally spaced waveform grooves 10 are provided on the clamp plate 9. Multiple waveform clamps 11 are provided on the clamp plate 9 respectively matching the waveform grooves 10.

[0038] It also includes a fixing mechanism, which is set on the base plate 1 through the support plate 7 in the fixing mechanism. The fixing mechanism is connected to the temperature control box 2 and the clamp plate 9 and is used to limit and fix the clamp plate 9.

[0039] Preferably, by Figures 1 to 3As shown, in this embodiment, two symmetrically distributed fixing blocks 23 are fixed on one side of the inner wall of the temperature control box 2. The fixing mechanism also includes a connecting rod 15 fixed on the support plate 7 and connected to the temperature control box 2. A sliding plate 14 is slidably connected on the connecting rod 15. A symmetrically distributed sliding rod 17 is provided on the side of the sliding plate 14 facing the temperature control box 2. The ends of the two sliding rods 17 are provided with movable fixing blocks 18. The sliding rods 17 are slidably connected to the temperature control box 2.

[0040] Both the movable snap-fit ​​block 18 and the fixed snap-fit ​​block 23 are provided with snap-fit ​​grooves 20 that are adapted to the clamp plate 9. A spring 16 is sleeved around the outside of the connecting rod 15. The spring 16 is located between the support plate 7 and the sliding plate 14.

[0041] When in use, open the box cover 3 and secure each tube of the lipid nanoparticle preparer into the corrugated groove 10 and the corrugated clamping plate 11 respectively. The corrugated groove 10 with a wave shape can increase the contact area between the tube and the clamping plate 9, thereby playing a better role in heat conduction. After arranging the tubes, close the box cover 3 and operate the temperature controller 4 for use. During use, the sliding plate 14 is continuously pushed by the spring 16, which will cause the movable clamping block 18 to press the side of the clamping plate 9, thereby cooperating with the fixed clamping block 23 to form a clamping action and achieve stable installation of the clamping plate 9.

[0042] During cleaning, after opening the box cover 3, pull out the sliding plate 14. When you observe that the two locking blocks 18 have disengaged from the clamp plate 9, remove the clamp plate 9. At this time, the tube is still on the clamp plate 9. The staff only needs to remove the tube from the lipid nanoparticle preparer to clean the tube. This setting not only facilitates quick disassembly and cleaning of the tube, but also has an indicative function, which can help the staff to install the cleaned tube with the lipid nanoparticle preparer, avoid installation errors, and improve practicality.

[0043] Preferably, by Figures 1 to 3 As shown, in this embodiment, through-pipe grooves 8 corresponding to the waveform grooves 10 are provided on both sides of the top of the temperature control box 2.

[0044] When installing the pipes, the pipes are passed through the corresponding through-pipe grooves 8 and then snapped into the corrugated grooves 10 one by one. This ensures that the cover 3 can be properly sealed and that the temperature inside the box can be controlled.

[0045] Preferably, by Figure 3 and Figure 6 As shown, in this embodiment, both the movable latching block 18 and the fixed latching block 23 are provided with beveled surfaces 19;

[0046] When installing the clamp plate 9, this design presses down on the clamp plate 9 so that its two sides are squeezed against the beveled surface 19, while the two movable locking blocks 18 on the other side are squeezed back, which facilitates the quick installation of the clamp plate 9. This eliminates the need to manually pull the sliding plate 14 during the installation process, simplifying the operation and making the installation process more convenient.

[0047] Preferably, by Figures 2 to 4 As shown, in this embodiment, heat dissipation holes 13 are provided at equal intervals on both sides of the heat insulation plate 12. The heat insulation plate 12 is located above the base plate 1 and is spaced apart from the base plate 1.

[0048] When the cooling fan 5 is turned on, the airflow is blown onto the clamp plate 9 and the heat insulation plate 12 to achieve cooling, and is discharged through the heat dissipation hole 13.

[0049] Preferably, by Figure 2 and Figure 4 As shown, in this embodiment, the base plate 1 has multiple ventilation holes 21 that connect to the temperature control box 2;

[0050] When cooling down, the cooling fan 5 is turned on, and the airflow will pass through the heat dissipation hole 13 and be discharged through the ventilation hole 21. This can effectively dissipate heat and cool down the inside of the temperature control box 2, so as to cooperate with the temperature controller 4 to achieve temperature control.

[0051] Preferably, by Figure 1 and Figure 8 As shown, in this embodiment, suction cup assemblies 6 are provided at the four corners of the base plate 1. The suction cup assembly 6 includes an integrally formed rubber suction cup 24 and a hardened sheet 26. A screw 27 is provided on the hardened sheet 26. A circular hole with a diameter larger than the screw 27 is opened on the base plate 1. A screw cap 25 is screwed onto the screw 27. The screw cap 25 and the rubber suction cup 24 are located on the upper and lower sides of the base plate 1, respectively.

[0052] When in use, turn the screw cap 25 clockwise, and the screw 27 will pull the suction cup assembly 6 upward. During the continuous turning process, the rubber suction cup 24 will be gradually tightened until it is firmly attached to the workbench. This setting facilitates the quick fixation of the base plate 1 and makes subsequent work easier.

[0053] Components not described in detail in this article are existing technologies.

[0054] The working principle and usage process of this utility model: When in use, open the box cover 3, so that each tube of the lipid nanoparticle preparer passes through the corresponding through-tube groove 8, and then is secured in the waveform groove 10 and waveform clamp 11. After arranging the tubes, the box cover 3 can be closed and the temperature controller 4 can be operated for use.

[0055] During cleaning, after opening the box cover 3, pull out the sliding plate 14. When you observe that the two snap-fit ​​blocks 18 have disengaged from the clamp plate 9, remove the clamp plate 9. At this time, the tube is still on the clamp plate 9. The staff only needs to remove the tube from the lipid nanoparticle preparer to clean the tube. This setting not only facilitates quick disassembly and cleaning of the tube, but also has an indicative function, which can help the staff to install the cleaned tube with the lipid nanoparticle preparer, avoid installation errors, and improve practicality.

[0056] When installing the clamp plate 9, pressing down on the clamp plate 9 causes the two sides to be pressed against the beveled surface 19, while the two movable locking blocks 18 on the other side are pressed back, which facilitates the quick installation of the clamp plate 9. This eliminates the need to manually pull the sliding plate 14 during the installation process, simplifying the operation and making the installation process more convenient.

[0057] Finally, it should be noted that the above description is merely a preferred embodiment of this utility model and is not intended to limit the utility model. Although the utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this utility model should be included within the protection scope of this utility model.

Claims

1. An external temperature control device for the preparation of lipid nanoparticles, comprising a base plate (1), characterized in that, A temperature control box (2) is provided on the top of the base plate (1), and a box cover (3) is rotatably connected to the temperature control box (2); A heat insulation plate (12) is provided inside the temperature control box (2); A temperature controller (4) is installed on one side of the top of the base plate (1), and an electric heating tube (22) connected to the wire of the temperature controller (4) is provided on the heat insulation plate (12). Multiple cooling fans (5) connected to the wire of the temperature controller (4) are installed on the cover (3). The temperature control box (2) is provided with a clamp plate (9), and multiple equally spaced waveform grooves (10) are provided on the clamp plate (9). Multiple waveform clamps (11) that match the waveform grooves (10) are provided on the clamp plate (9). It also includes a fixing mechanism, which is set on the base plate (1) through the support plate (7) in the fixing mechanism. The fixing mechanism is connected to the temperature control box (2) and the clamp plate (9) and is used to limit and fix the clamp plate (9).

2. The external temperature control device for preparing lipid nanoparticles according to claim 1, characterized in that, Two symmetrically distributed fixing blocks (23) are fixed on one side of the inner wall of the temperature control box (2). The fixing mechanism also includes a connecting rod (15) fixed on the support plate (7) and connected to the temperature control box (2). A sliding plate (14) is slidably connected on the connecting rod (15). A symmetrically distributed sliding rod (17) is provided on the side of the sliding plate (14) facing the temperature control box (2). Movable fixing blocks (18) are provided at the ends of the two sliding rods (17). The sliding rods (17) are slidably connected to the temperature control box (2). Both the movable snap-fit ​​block (18) and the fixed snap-fit ​​block (23) are provided with snap-fit ​​grooves (20) that are adapted to the clamp plate (9). A spring (16) is sleeved around the outside of the connecting rod (15). The spring (16) is located between the support plate (7) and the sliding plate (14).

3. The external temperature control device for preparing lipid nanoparticles according to claim 1, characterized in that, On both sides of the top of the temperature control box (2), there are through-pipe grooves (8) that correspond one-to-one with the waveform grooves (10).

4. The external temperature control device for preparing lipid nanoparticles according to claim 2, characterized in that, Both the movable latching block (18) and the fixed latching block (23) are provided with beveled surfaces (19).

5. The external temperature control device for preparing lipid nanoparticles according to claim 1, characterized in that, Heat dissipation holes (13) are provided at equal intervals on both sides of the heat insulation plate (12). The heat insulation plate (12) is located above the base plate (1) and is spaced apart from the base plate (1).

6. The external temperature control device for preparing lipid nanoparticles according to claim 1, characterized in that, The base plate (1) has multiple ventilation holes (21) that connect to the temperature control box (2).

7. The external temperature control device for preparing lipid nanoparticles according to claim 1, characterized in that, Suction cup assemblies (6) are provided at the four corners of the base plate (1). Each suction cup assembly (6) includes an integrally formed rubber suction cup (24) and a hardening sheet (26). A screw (27) is provided on the hardening sheet (26). A circular hole with a diameter larger than that of the screw (27) is opened on the base plate (1). A screw cap (25) is screwed onto the screw (27). The screw cap (25) and the rubber suction cup (24) are located on the upper and lower sides of the base plate (1), respectively.

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