An experimental mouse alveolar lavage device

Abstract

The utility model discloses a kind of experimental mouse alveolus lavage devices, including the fixing platform for fixing mouse, the syringe for providing lavage liquid, the lavage needle for implementing lavage, the lavage needle fixing joint detachably connected with lavage needle, and the hose of connecting syringe and lavage needle fixing joint;Hose is equipped with hose fixing component, hose fixing component has two mutually parallel fixed surfaces, hose hole is opened on hose fixing component, for hose passes through, the outer wall of hose is fixedly connected with the inner wall of hose hole;Fixing platform is equipped with hose fixing mechanism, and hose fixing mechanism includes fixed frame and binding bolt with the thread connection of fixed frame, two fixed surfaces are respectively matched with the inner wall of fixed frame and the end of binding bolt.The utility model is fixed through the hose fixing component arranged on hose and the hose fixing mechanism arranged on fixing platform in the process of lavage, the fixing of hose and lavage needle, it is convenient for user operation.

Description

Technical Field

[0001] This utility model relates to the technical field of lavage devices, and in particular to an experimental mouse alveolar lavage device. Background Technology

[0002] Mice are commonly used laboratory animals to construct various human disease models and are widely used in basic medical research and drug development. Mouse lung disease models are one such widely used model, and their construction often requires alveolar lavage. Currently, researchers commonly use simple syringes with needles for rudimentary mouse alveolar lavage, which also results in poor mouse fixation. This complex procedure can easily damage mouse tissues, leading to experimental errors or even failure. Utility Model Content

[0003] In view of this, the purpose of this utility model is to provide an experimental mouse alveolar lavage device.

[0004] To achieve the above objectives, the technical solution adopted by this utility model is as follows:

[0005] An experimental mouse alveolar lavage device includes: a fixation table for fixing the mouse, a syringe for providing lavage fluid, an lavage needle for performing lavage, an lavage needle fixing connector detachably connected to the lavage needle, and a tubing connecting the syringe and the lavage needle fixing connector.

[0006] The hose is provided with a hose fixing member, which has two parallel fixing surfaces and a hose hole for the hose to pass through. The outer wall of the hose is fixedly connected to the inner wall of the hose hole.

[0007] The fixing platform is provided with a hose fixing mechanism, which includes a fixing frame and a set bolt threadedly connected to the fixing frame. The two fixing surfaces are respectively matched with the inner wall of the fixing frame and the end of the set bolt.

[0008] The aforementioned experimental mouse alveolar lavage apparatus further includes: a column fixedly connected to the upper surface of the fixed platform, and a crossbeam fixedly connected to the column, wherein the set bolt passes through the crossbeam and the fixed frame in sequence;

[0009] The set bolt is threadedly connected to the crossbeam.

[0010] In the above-mentioned experimental mouse alveolar lavage device, the fixing frame is a rectangular frame, the hose fixing member is rectangular, and the hose fixing member can be disposed inside the rectangular frame.

[0011] In the aforementioned experimental mouse alveolar lavage apparatus, the end of the set bolt is provided with a pressure plate, and one of the fixing surfaces matches the pressure plate at the end of the set bolt.

[0012] The above-mentioned experimental mouse alveolar lavage device includes a fixing groove on the upper surface of the fixing platform for placing mice.

[0013] One or more fixing rings are provided at the fixing groove. One end of the fixing ring is rotatably connected to the upper surface of the fixing platform, and the other end of the fixing ring is connected to the upper surface of the fixing platform by a snap fastener.

[0014] The fixing rings include a head fixing ring for fixing the mouse's head and a body fixing ring for fixing the mouse's body.

[0015] The above-mentioned experimental mouse alveolar lavage apparatus, wherein the fixed stage is triangular prism-shaped;

[0016] The lower end of the fixed platform is provided with two fixed support legs that are fixedly connected to the fixed platform;

[0017] The lower end of the fixed platform is provided with an adjusting foot that is threadedly connected to the fixed platform.

[0018] In the above-mentioned experimental mouse alveolar lavage device, the lavage needle is threadedly connected to the lavage needle fixing connector.

[0019] The above-mentioned experimental mouse alveolar lavage device includes a sealing protective shell on the lavage needle, which is threadedly connected to the lavage needle fixing connector.

[0020] The aforementioned experimental mouse alveolar lavage apparatus further includes: a switching device, which is sleeved on the flexible tube and has a variable diameter groove for the flexible tube to pass through.

[0021] The aforementioned experimental mouse alveolar lavage device includes a variable diameter groove comprising a first part and a second part that are interconnected, wherein the inner diameter of the first part is larger than the inner diameter of the second part.

[0022] Because this utility model employs the aforementioned technology, it has the following positive effects compared to existing technologies:

[0023] (1) This utility model achieves the fixation of the hose and irrigation needle during the irrigation process by means of the hose fixing component arranged on the hose and the hose fixing mechanism arranged on the fixing platform, which facilitates the operation of the user.

[0024] (2) The design of the tubing, irrigation needle and mouse fixation device of this utility model makes the alveolar lavage operation simpler and more effective and basically does not cause damage to mice. Attached Figure Description

[0025] To more clearly illustrate the technical solutions in the embodiments of this utility model, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0026] Figure 1 This is a schematic diagram of a syringe for an experimental mouse bronchoalveolar lavage apparatus as shown in some embodiments of this specification.

[0027] Figure 2 This is a schematic diagram of the lavage needle, lavage needle fixing connector, and tubing of an experimental mouse alveolar lavage apparatus according to some embodiments of this specification.

[0028] Figure 3 This is a schematic diagram of the mounting platform of an experimental mouse alveolar lavage apparatus according to some embodiments of this specification.

[0029] Figure 4 This is a schematic diagram of the tubing fixing mechanism of an experimental mouse alveolar lavage apparatus according to some embodiments of this specification.

[0030] In the attached diagram: 1. Fixing platform; 11. Fixing groove; 12. Fixing ring; 2. Syringe; 3. Irrigation needle; 4. Irrigation needle fixing connector; 5. Hose; 51. Hose fixing component; 6. Hose fixing mechanism; 61. Fixing frame; 62. Set bolt; 63. Column; 64. Crossbeam; 65. Pressure plate; 71. Fixing support; 72. Adjusting support; 8. Sealing protective shell; 9. Switching device; 91. First part; 92. Second part. Detailed Implementation

[0031] To more clearly illustrate the technical solutions of the embodiments in this specification, the embodiments will be described in detail below with reference to the accompanying drawings. Obviously, the content described below are some examples or embodiments of this specification. For those skilled in the art, without creative effort, the technical solutions or means disclosed in this specification can be applied to other scenarios based on this technical content.

[0032] It should be understood that the terms "system," "device," "equipment," "part" and / or "component," "unit" and / or "module" used in this specification are a method of distinguishing different components, elements, parts, sections, or assemblies at different levels. However, if other words can achieve the same purpose, they may be replaced by other expressions.

[0033] Unless otherwise specified, the technical terms used to describe components, elements, etc. in this specification are not singular but may include plural. Generally speaking, terms such as "comprising" or "including" only indicate that explicitly identified steps, elements, or components are included, and these steps, elements, and components do not constitute an exclusive list, as the described method or apparatus may also include other steps or components.

[0034] In the description of this specification, it should be understood that the directional descriptions, such as up, down, front, back, left, and right, indicating the orientation or positional relationship, are based on the orientation or positional relationship shown in the accompanying drawings. These descriptions are for the convenience of describing this application and for simplification, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this application. In the description of this specification, unless otherwise expressly defined, terms such as "setting," "installation," and "connection" should be interpreted broadly. Those skilled in the art can reasonably determine the specific meaning of the above terms in this specification in conjunction with the specific content of the technical solution.

[0035] Figure 1 This is a schematic diagram of a syringe used in an experimental mouse alveolar lavage apparatus, as shown in some embodiments of this specification. Figure 2 This is a schematic diagram of the lavage needle, lavage needle fixing connector, and tubing of an experimental mouse alveolar lavage apparatus according to some embodiments of this specification. Figure 3 This is a schematic diagram of the mounting platform of the experimental mouse alveolar lavage apparatus shown in some embodiments of this specification. Figure 4 This is a schematic diagram of the tubing fixing mechanism of an experimental mouse alveolar lavage apparatus according to some embodiments of this specification. See also Figures 1 to 4 As shown, in one or more embodiments of this specification, the experimental mouse alveolar lavage apparatus may include: a fixation table 1 for fixing the mouse, a syringe 2 for providing lavage fluid, an lavage needle 3 for performing lavage, an lavage needle fixing connector 4 detachably connected to the lavage needle 3, and a tubing 5 connecting the syringe 2 and the lavage needle fixing connector 4. In some embodiments, the syringe 2 is used to temporarily store and contain lavage fluid (such as physiological saline or paraformaldehyde), and lavages the mouse alveoli sequentially through the tubing 5, the lavage needle fixing connector 4, and the lavage needle 3.

[0036] In some embodiments, the hose 5 is provided with a hose fixing member 51, the hose fixing member 51 has two mutually parallel fixing surfaces, the hose fixing member 51 is provided with a hose hole for the hose 5 to pass through, and the outer wall of the hose 5 is fixedly connected to the inner wall of the hose hole of the hose fixing member 51.

[0037] In some embodiments, the fixed platform 1 is provided with a hose fixing mechanism 6, which includes a fixed frame 61 and a set bolt 62 threadedly connected to the fixed frame 61. The two fixing surfaces are respectively matched with the inner wall of the fixed frame 61 and the end of the set bolt 62.

[0038] In some embodiments, the hose fixing member 51 may be made of metal. In some embodiments, the hose fixing member 51 is located at the junction of the irrigation needle 3 and the hose 5. In some embodiments, the hose fixing member 51 is mainly used to fix the irrigation needle 3 during use.

[0039] In some embodiments, the hose fixing mechanism 6 further includes: a column 63 fixedly connected to the upper surface of the fixing platform 1, a crossbeam 64 fixedly connected to the column 63, and a set bolt 62 passing through the crossbeam 64 and the fixing frame 61 in sequence. In some embodiments, the set bolt 62 is threadedly connected to the crossbeam 64.

[0040] In some embodiments, the fixing frame 61 is a rectangular frame, and the hose fixing member 51 is rectangular, with two oppositely arranged surfaces of the rectangular structure forming the aforementioned fixing surface. In some embodiments, the hose fixing member 51 can be disposed inside the rectangular fixing frame 61.

[0041] In some embodiments, the end of the set bolt 62 is provided with a pressure plate 65, and one of the fixing surfaces of the hose fixing member 51 matches the pressure plate 65 at the end of the set bolt 62. See also Figure 4 As shown, the pressure plate 65 is lowered by rotating the set bolt 62 to cooperate with the rectangular fixing frame 61 to clamp the hose fixing member 51.

[0042] In one or more embodiments of this specification, the upper surface of the fixing platform 1 is provided with a fixing groove 11 for placing a mouse. In some embodiments, the fixing groove 11 may include a head fixing groove and a body fixing groove that are in communication with each other.

[0043] In some embodiments, one or more fixing rings 12 are provided at the fixing groove 11. One end of the fixing ring 12 is rotatably connected to the upper surface of the fixing platform 1, and the other end of the fixing ring 12 is connected to the upper surface of the fixing platform 1 by a snap fastener.

[0044] In some embodiments, the retaining ring 12 includes a head retaining ring for retaining the head of the mouse and a body retaining ring for retaining the body of the mouse.

[0045] In some embodiments, anesthetized mice are placed in the fixing slot 11 of the fixing platform 1, and the limbs and torso are fixed by snap-fit ​​rings 12, such as mouse head fixing rings and mouse body fixing rings.

[0046] In some embodiments, the fixed platform 1 is triangular prism-shaped. In some embodiments, the lower end of the fixed platform 1 is provided with two fixed legs 71 fixedly connected to the fixed platform 1. In some embodiments, the lower end of the fixed platform 1 is provided with an adjusting leg 72 threadedly connected to the fixed platform 1. In some embodiments, the effective length of the adjusting leg 72 is adjusted by rotating the adjusting leg 72, thereby adjusting the levelness or angle of the upper surface of the fixed platform 1. In some embodiments, the stability of the fixed platform can be adjusted by rotating the adjusting leg 72, making it highly versatile.

[0047] When using the device, place the experimental mouse alveolar lavage apparatus in a suitable position, adjust the adjustable foot 72 until the apparatus is stable, take out the treated mouse and place it in the fixed slot 11 on the table, and close the mouse body fixing ring and mouse head fixing ring in sequence. Then the mouse alveolar lavage experiment can be carried out.

[0048] In some embodiments, the irrigation needle 3 is threadedly connected to the irrigation needle fixing connector 4 to facilitate the replacement of needles of different specifications (such as a No. 4 half infusion set needle).

[0049] In some embodiments, the irrigation needle 3 is provided with a sealing protective shell 8, which is threadedly connected to the irrigation needle fixing connector 4 to prevent liquid leakage, prevent damage to the irrigation needle 3, and avoid possible harm to the user caused by the irrigation needle 3.

[0050] In one or more embodiments of this specification, the experimental mouse alveolar lavage device further includes: a switch device 9, which is sleeved on the hose 5 and has a variable diameter groove for the hose 5 to pass through.

[0051] In some embodiments, the variable diameter channel includes a first portion 91 and a second portion 92 that are interconnected, wherein the inner diameter of the first portion 91 is larger than the inner diameter of the second portion 92. In some embodiments, the flow rate is adjusted by flushing through the variable diameter channel. In some embodiments, the larger inner diameter of the first portion 91 allows for rapid flushing, while the smaller inner diameter of the second portion 92 allows for precise control. In some embodiments, the second portion 92 may further serve as a shut-off function to stop flushing.

[0052] In this embodiment, the design of the tubing, irrigation needle, and mouse fixation device makes the alveolar lavage procedure simpler and more effective, and virtually does not cause damage to the mice.

[0053] The above description is only a preferred embodiment of the present utility model and does not limit the implementation method and protection scope of the present utility model. Those skilled in the art should realize that all solutions obtained by equivalent substitutions and obvious changes made based on the description and illustrations of the present utility model should be included within the protection scope of the present utility model.

Claims

1. An experimental mouse alveolar lavage device, characterized in that, include: A fixation table for stabilizing mice, a syringe for providing irrigation fluid, an irrigation needle for performing irrigation, an irrigation needle fixing connector detachably connected to the irrigation needle, and a tubing connecting the syringe and the irrigation needle fixing connector. The hose is provided with a hose fixing component, which has two parallel fixing surfaces and a hose hole for the hose to pass through. The outer wall of the hose is fixedly connected to the inner wall of the hose hole. The fixing platform is provided with a hose fixing mechanism, which includes a fixing frame and a set bolt threadedly connected to the fixing frame. The two fixing surfaces are respectively matched with the inner wall of the fixing frame and the end of the set bolt.

2. The experimental mouse alveolar lavage apparatus according to claim 1, characterized in that, Also includes: The column is fixedly connected to the upper surface of the fixed platform, and the crossbeam is fixedly connected to the column. The set bolt passes through the crossbeam and the fixed frame in sequence. The set bolt is threadedly connected to the crossbeam.

3. The experimental mouse alveolar lavage apparatus according to claim 1 or 2, characterized in that, The fixing frame is a rectangular frame, and the hose fixing component is rectangular and can be disposed inside the rectangular frame.

4. The experimental mouse alveolar lavage apparatus according to claim 3, characterized in that, The set bolt has a pressure plate at its end, and one of the fixing surfaces matches the pressure plate at the end of the set bolt.

5. The experimental mouse alveolar lavage apparatus according to claim 1, characterized in that, The upper surface of the fixed platform is provided with a fixing groove for placing mice; One or more fixing rings are provided at the fixing groove. One end of the fixing ring is rotatably connected to the upper surface of the fixing platform, and the other end of the fixing ring is connected to the upper surface of the fixing platform by a snap fastener. The fixing rings include a head fixing ring for fixing the mouse's head and a body fixing ring for fixing the mouse's body.

6. The experimental mouse alveolar lavage apparatus according to claim 1, characterized in that, The fixed platform is in the shape of a triangular prism; The lower end of the fixed platform is provided with two fixed support legs that are fixedly connected to the fixed platform; The lower end of the fixed platform is provided with an adjusting foot that is threadedly connected to the fixed platform.

7. The experimental mouse alveolar lavage apparatus according to claim 1, characterized in that, The irrigation needle is threadedly connected to the irrigation needle fixing connector.

8. The experimental mouse alveolar lavage apparatus according to claim 7, characterized in that, The irrigation needle is provided with a sealing protective shell, which is threadedly connected to the fixing joint of the irrigation needle.

9. The experimental mouse alveolar lavage apparatus according to claim 1, characterized in that, Also includes: A switching device is sleeved on the flexible hose, and the switching device is provided with a variable diameter groove for the flexible hose to pass through.

10. The experimental mouse alveolar lavage apparatus according to claim 9, characterized in that, The variable diameter groove includes a first part and a second part that are interconnected, wherein the inner diameter of the first part is larger than the inner diameter of the second part.

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