A reaction device for preparing cross-linked sodium hyaluronate

Abstract

The utility model discloses a reaction device for crosslinking sodium hyaluronate preparation relates to crosslinking sodium hyaluronate preparation technical field, including bottom plate and motor, bottom plate: the left and right sides of top surface all are fixed with frame, the front and back two sides of frame inside all install the position corresponding main linear motor, the inside surface of main linear motor mobile base is connected with the end of support one side, the inside end of support is connected with the outside surface of sealing cover, the motor is fixed in the top surface middle part of sealing cover, the output shaft of motor is connected with the top end of coupling, this reaction device for crosslinking sodium hyaluronate preparation passes through integrated automation control, accurate quantitative feeding, dynamic temperature control and high -efficient mixing design, has improved the homogeneity, repeatability and production efficiency of sodium hyaluronate crosslinking reaction significantly, has reduced manual operation error simultaneously, has extensive application value in scientific research and industrial production.

Description

Technical Field

[0001] This utility model relates to the field of cross-linked sodium hyaluronate preparation technology, specifically a reaction apparatus for the preparation of cross-linked sodium hyaluronate. Background Technology

[0002] Sodium hyaluronate is the sodium salt of hyaluronic acid, a glucuronic acid, a natural polysaccharide widely found in human connective tissue, skin, eyes, and synovial fluid. It possesses excellent moisturizing, anti-aging, repairing, and lubricating properties, making it widely used in beauty, medicine, and health care. The molecular structure of sodium hyaluronate consists of alternating glucuronic acid and N-acetylglucosamine, giving it a strong water-absorbing capacity; each molecule can absorb hundreds of times its own weight in water, thus significantly improving skin hydration and elasticity. However, natural sodium hyaluronate is easily degraded by enzymes in vivo, exhibiting poor mechanical strength and stability. Therefore, cross-linking modification (such as chemical cross-linking and physical cross-linking) is often used to prolong its action time and enhance its performance. Traditional crosslinking reaction apparatus suffers from uneven mixing and inaccurate temperature control. Insufficient mixing of the crosslinking agent and sodium hyaluronate solution leads to uneven crosslinking degree, affecting product performance. Furthermore, the crosslinking reaction is temperature-sensitive, and traditional apparatuses lack sufficient temperature control precision, easily resulting in over- or under-reaction. Therefore, we propose a reaction apparatus for the preparation of crosslinked sodium hyaluronate. Utility Model Content

[0003] The technical problem to be solved by this utility model is to overcome the existing defects and provide a reaction device for the preparation of cross-linked sodium hyaluronate. By integrating automated control, precise quantitative feeding, dynamic temperature control and efficient mixing design, it significantly improves the uniformity, repeatability and production efficiency of the sodium hyaluronate cross-linking reaction, while reducing human operation errors. It has wide application value in scientific research and industrial production and can effectively solve the problems in the background technology.

[0004] To achieve the above objectives, this utility model provides the following technical solution: a reaction apparatus for the preparation of cross-linked sodium hyaluronate, comprising a base plate and a motor; Base plate: Frames are fixed on both the left and right sides of the top surface. Main linear motors are installed on the front and rear sides of the frame. The inner side of the main linear motor's moving part is connected to the end of one side of the bracket. The inner end of the bracket is connected to the outer side of the sealing cover. The motor is fixed in the middle of the top surface of the sealing cover. The output shaft of the motor is connected to the top of the coupling. The bottom end of the coupling is connected to the top of the dispersing and stirring rack. A metering unit is provided on the bottom surface inside the sealing cover. A temperature control unit is provided inside the sealing cover. It also includes a controller, which is located on the front side of the right frame. The main linear motor and the input end of the motor are electrically connected to the output end of the controller, and the input end of the controller is electrically connected to the output end of an external power source.

[0005] The main linear motor is started, which drives the sealing cover to descend and cover the top of the preparation tank. The motor drives the dispersion and stirring rack to rotate at high speed to disperse and stir the various raw materials inside the preparation tank.

[0006] Furthermore, the quantitative unit includes a flow sensor, a distribution ring, a dripping head, a delivery pipe, a liquid pump, and a suction pipe. The distribution ring is fixed to the bottom surface inside the sealing cap. The bottom surface of the distribution ring is uniformly equipped with dripping heads around its center axis. The inlet pipe on the top surface of the distribution ring is connected to the outlet of the delivery pipe. The inlet of the delivery pipe is connected to the outlet of the liquid pump. The inlet of the liquid pump is equipped with a suction pipe. The flow sensor is installed on the outside of the delivery pipe. The input end of the delivery pipe is electrically connected to the output end of the controller. The output end of the flow sensor is electrically connected to the input end of the controller. The suction pipe is inserted into the crosslinking agent tank. The liquid pump is started to slowly drip the crosslinking agent into the preparation tank through the dripping heads uniformly arranged on the bottom surface of the distribution ring. The flow sensor can control the accuracy of the crosslinking agent addition amount to prevent uneven mixing and clumping caused by excessively rapid addition of the crosslinking agent.

[0007] Furthermore, the temperature control unit includes a temperature sensor, a mounting base, fixing bolts, a heating element, and a temperature controller. There are two mounting bases, fixed to the left and right sides inside the sealing cover respectively. The top surface of the heating element is provided with fixing bolts, which are threaded into the screw holes inside the mounting base. The temperature sensor is installed on the front side of the top surface of the sealing cover. The temperature controller is fixed to the front side of the left frame. The input end of the heating element is electrically connected to the output end of the temperature controller, the input end of the temperature controller is electrically connected to the output end of the controller, and the output end of the temperature sensor is electrically connected to the input end of the controller. The fixing bolts are threaded into the mounting base to install the heating element. The temperature sensor can detect the temperature inside the preparation tank in real time and simultaneously activate the temperature controller to adjust the heating element temperature to avoid temperature fluctuations that could lead to excessive or insufficient crosslinking.

[0008] Furthermore, it also includes a secondary linear motor, a placement plate, and limiting clamps. There are two secondary linear motors, each fixed in a groove on the top surface of the base plate. The top surface of the secondary linear motor's moving part is connected to one side of the bottom surface of the placement plate. The top surface of the placement plate is provided with two corresponding left and right limiting clamps. The input end of the secondary linear motor is electrically connected to the output end of the controller. Activating the secondary linear motor drives the placement plate to move, making it convenient for personnel to pick up the preparation tank. The fixed limiting clamps can limit the movement of the preparation tank.

[0009] Furthermore, it also includes an electric telescopic rod, a box frame, and a cleaning box. There are two electric telescopic rods, each fixed to the rear side of a corresponding frame. The front end of the electric telescopic rod is connected to one end of the rear side of the box frame. The cleaning box is inserted into the box frame. The input end of the electric telescopic rod is electrically connected to the output end of the controller. Activating the electric telescopic rod moves the cleaning box to the lower side of the dispersing and mixing rack, which facilitates the collection of dripping residual liquid or waste when cleaning the dispersing and mixing rack.

[0010] Furthermore, it also includes a display screen, which is fixed to the top of the front side of the right frame. The input end of the display screen is electrically connected to the output end of the controller. The display screen displays the detection data in real time to facilitate personnel to view and adjust it.

[0011] Compared with the prior art, the beneficial effects of this utility model are as follows: This reaction apparatus for the preparation of cross-linked sodium hyaluronate has the following advantages: 1. By starting the liquid pump, the crosslinking agent is slowly dripped into the preparation tank through the evenly distributed dropper head on the bottom surface of the distribution ring. The flow sensor can control the accuracy of the amount of crosslinking agent added to prevent the problem of clumping caused by the crosslinking agent being added too quickly.

[0012] 2. The heating tube is installed by fixing bolts and mounting the internal threads of the mounting base. The temperature sensor can detect the temperature inside the preparation tank in real time, and at the same time, the temperature controller is activated to adjust the temperature of the heating tube to avoid excessive or insufficient crosslinking caused by temperature fluctuations.

[0013] 3. Move the cleaning box to the lower side of the dispersing and mixing rack by activating the electric telescopic rod. This makes it easier for personnel to collect any dripping residual liquid or waste when cleaning the dispersing and mixing rack. Attached Figure Description

[0014] Figure 1 This is a schematic diagram of the structure of this utility model; Figure 2 This is a schematic diagram of the rear side structure of this utility model; Figure 3 This is a schematic diagram of the quantitative unit structure of this utility model.

[0015] In the diagram: 1. Base plate, 2. Quantitative unit, 21. Flow sensor, 22. Distribution ring, 23. Dropper head, 24. Delivery pipe, 25. Liquid pump, 26. Suction pipe, 3. Temperature control unit, 31. Temperature sensor, 32. Mounting base, 33. Fixing bolt, 34. Heating tube, 35. Temperature controller, 4. Frame, 5. Main linear motor, 6. Bracket, 7. Sealing cover, 8. Motor, 9. Coupling, 10. Dispersing and stirring rack, 11. Secondary linear motor, 12. Placement plate, 13. Limiting clamp, 14. Electric telescopic rod, 15. Box rack, 16. Cleaning box, 17. Display screen, 18. Controller. Detailed Implementation

[0016] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0017] Please see Figure 1-3 This embodiment provides a technical solution: a reaction apparatus for preparing cross-linked sodium hyaluronate, including a base plate 1 and a motor 8; Base plate 1: Frames 4 are fixed on both the left and right sides of the top surface. Main linear motors 5 are installed on the front and rear sides of the interior of the frames 4. The inner side of the main linear motor 5's mover is connected to one end of a bracket 6. The inner end of the bracket 6 is connected to the outer side of the sealing cover 7. A motor 8 is fixed in the middle of the top surface of the sealing cover 7. The output shaft of the motor 8 is connected to the top of a coupling 9. The bottom end of the coupling 9 is connected to the top of a dispersing and stirring rack 10. A metering unit 2 is provided on the bottom surface inside the sealing cover 7. The metering unit 2 includes a flow sensor 21, a distribution ring 22, a drip head 23, a delivery pipe 24, and a liquid pump 25. The suction tube 26 and the distribution ring 22 are fixed to the bottom surface inside the sealing cover 7. Drop heads 23 are evenly installed on the bottom surface of the distribution ring 22 with the center as the axis. The inlet pipe on the top surface of the distribution ring 22 is connected to the outlet of the delivery pipe 24. The inlet of the delivery pipe 24 is connected to the outlet of the liquid pump 25. The suction tube 26 is installed at the inlet of the liquid pump 25. The flow sensor 21 is installed on the outside of the delivery pipe 24. The input end of the delivery pipe 24 is electrically connected to the output end of the controller 18, and the output end of the flow sensor 21 is electrically connected to the input end of the controller 18. The suction tube 26 is inserted into the crosslinking agent tank, and the liquid pump 25 is started to deliver the crosslinking agent through... The liquid is slowly dripped into the preparation tank through the evenly distributed drip heads 23 on the bottom surface of the distribution ring 22. The flow sensor 21 controls the accuracy of the crosslinking agent addition to prevent uneven mixing and clumping caused by excessively rapid addition. The sealing cover 7 is equipped with a temperature control unit 3, which includes a temperature sensor 31, a mounting base 32, fixing bolts 33, a heating tube 34, and a temperature controller 35. There are two mounting bases 32, which are fixed on the left and right sides inside the sealing cover 7, respectively. The top surface of the heating tube 34 is equipped with fixing bolts 33, which are threaded into the screw holes inside the mounting base 32. The temperature sensor 31 is installed on the front side of the top surface of the sealing cover 7, and the temperature controller 35 is fixed on the front side of the left frame 4. The input end of the heating tube 34 is electrically connected to the output end of the temperature controller 35, the input end of the temperature controller 35 is electrically connected to the output end of the controller 18, and the output end of the temperature sensor 31 is electrically connected to the input end of the controller 18. The fixing bolt 33 is installed with the internal thread of the mounting base 32 to install the heating tube 34. The temperature sensor 31 can detect the temperature inside the preparation tank in real time, and at the same time, the temperature controller 35 is activated to adjust the temperature of the heating tube 34 to avoid temperature fluctuations that may cause excessive or insufficient crosslinking. The system also includes a controller 18, located on the front side of the right frame 4. The input terminals of the main linear motor 5 and motor 8 are electrically connected to the output terminal of the controller 18, which in turn is electrically connected to the output terminal of an external power supply. Starting the main linear motor 5 causes the sealing cover 7 to descend and cover the top of the preparation tank. Motor 8 drives the dispersing and stirring rack 10 to rotate at high speed to disperse and stir the various raw materials inside the preparation tank. The system also includes a secondary linear motor 11, a placement plate 12, and limiting clamps 13. There are two secondary linear motors 11, each fixed in a groove on the top surface of the base plate 1. The top surface of the actuator of the secondary linear motor 11 is connected to one side of the bottom surface of the placement plate 12. The top surface of the placement plate 12 has two corresponding limiting clamps 13. The input terminal of the secondary linear motor 11 is electrically connected to the output terminal of the controller 18. Starting the secondary linear motor 11 causes the placement plate 12 to move, facilitating personnel to operate the preparation tank. The preparation tank is picked up, and the fixed limiting clamp 13 can limit the movement of the preparation tank. It also includes an electric telescopic rod 14, a box frame 15, and a cleaning box 16. There are two electric telescopic rods 14, which are fixed to the rear side of the corresponding two frames 4. The front end of the electric telescopic rod 14 is connected to one end of the rear side of the box frame 15. The cleaning box 16 is inserted into the box frame 15. The input end of the electric telescopic rod 14 is electrically connected to the output end of the controller 18. Activating the electric telescopic rod 14 moves the cleaning box 16 to the lower side of the dispersion and mixing rack 10, which facilitates the collection of dripping residual liquid or waste when cleaning the dispersion and mixing rack 10. It also includes a display screen 17, which is fixed to the top of the front side of the right frame 4. The input end of the display screen 17 is electrically connected to the output end of the controller 18. The display screen 17 displays the detection data in real time for easy viewing and adjustment by personnel.

[0018] The working principle of the reaction device for preparing cross-linked sodium hyaluronate provided by this utility model is as follows: First, the preparation tank containing the raw materials is placed on the top surface of the placement plate 12. The fixed limiting clamp 13 can limit the preparation tank. The auxiliary linear motor 11 is started to drive the preparation tank to move to the lower side of the sealing cover 7. The suction tube 26 is inserted into the cross-linking agent tank. The main linear motor 5 is started to drive the sealing cover 7 to fall and cover the top surface of the preparation tank. The liquid pump 25 is started to slowly drip the cross-linking agent into the preparation tank through the drip heads 23 evenly arranged on the bottom surface of the distribution ring 22. The flow sensor 21 can control the accuracy of the amount of cross-linking agent added. At the same time, the motor 8 drives... The high-speed rotation of the dispersion stirring rack 10 disperses and stirs the various raw materials inside the preparation tank to prevent uneven mixing and clumping caused by excessively rapid addition of the crosslinking agent. The fixing bolt 33 is installed in the internal thread of the mounting base 32 to install the heating tube 34. The temperature sensor 31 can detect the temperature inside the preparation tank in real time. At the same time, the temperature controller 35 is activated to adjust the temperature of the heating tube 34 to avoid temperature fluctuations that may cause excessive or insufficient crosslinking. After the preparation is completed, the electric telescopic rod 14 is activated to move the cleaning box 16 to the lower side of the dispersion stirring rack 10, which facilitates the collection of dripping residual liquid or waste when cleaning the dispersion stirring rack 10.

[0019] It is worth noting that the controller 18 disclosed in the above embodiments is model S7-1200, while the flow sensor 21 can be freely configured according to the actual application scenario. It is recommended to use a flow sensor of model SLF3X. The motor 8 can be a stepper motor of model 57HS22, and the temperature controller 35 can be a temperature controller of model E5CC-QX2ASM-800. The controller 18 controls the flow sensor 21, liquid pump 25, temperature sensor 31, heating tube 34, temperature controller 35, main linear motor 5, motor 8, auxiliary linear motor 11, electric telescopic rod 14, and display screen 17 using methods commonly used in the prior art.

[0020] The above description is merely an embodiment of this utility model and does not limit the patent scope of this utility model. Any equivalent structural or procedural transformations made based on the content of this utility model specification and drawings, or direct or indirect applications in other related technical fields, are similarly included within the patent protection scope of this utility model.

Claims

1. A reaction apparatus for the preparation of cross-linked sodium hyaluronate, characterized in that: Includes base plate (1) and motor (8); Base plate (1): Frames (4) are fixed on both the left and right sides of the top surface. Main linear motors (5) with corresponding positions are installed on the front and rear sides of the frame (4). The inner side of the moving part of the main linear motor (5) is connected to the end of one side of the bracket (6). The inner end of the bracket (6) is connected to the outer side of the sealing cover (7). The motor (8) is fixed in the middle of the top surface of the sealing cover (7). The output shaft of the motor (8) is connected to the top of the coupling (9). The bottom end of the coupling (9) is connected to the top of the dispersing and stirring rack (10). A quantitative unit (2) is provided on the bottom surface inside the sealing cover (7). A temperature control unit (3) is provided inside the sealing cover (7). The system also includes a controller (18), which is located on the front side of the right frame (4). The input terminals of the main linear motor (5) and the motor (8) are electrically connected to the output terminal of the controller (18), and the input terminal of the controller (18) is electrically connected to the output terminal of an external power source.

2. The reaction apparatus for preparing cross-linked sodium hyaluronate according to claim 1, characterized in that: The quantitative unit (2) includes a flow sensor (21), a distribution ring (22), a drip head (23), a delivery pipe (24), a liquid pump (25), and a suction pipe (26). The distribution ring (22) is fixed to the bottom surface inside the sealing cover (7). The drip heads (23) are evenly installed on the bottom surface of the distribution ring (22) with the center as the axis. The inlet pipe on the top surface of the distribution ring (22) is connected to the outlet of the delivery pipe (24). The inlet of the delivery pipe (24) is connected to the outlet of the liquid pump (25). The inlet of the liquid pump (25) is equipped with a suction pipe (26). The flow sensor (21) is installed on the outside of the delivery pipe (24). The input end of the delivery pipe (24) is electrically connected to the output end of the controller (18). The output end of the flow sensor (21) is electrically connected to the input end of the controller (18).

3. The reaction apparatus for preparing cross-linked sodium hyaluronate according to claim 1, characterized in that: The temperature control unit (3) includes a temperature sensor (31), a mounting base (32), a fixing bolt (33), a heating tube (34), and a temperature controller (35). There are two mounting bases (32) and they are fixed on the left and right sides inside the sealing cover (7). The top surface of the heating tube (34) is provided with a fixing bolt (33). The fixing bolt (33) is threaded into the screw hole inside the mounting base (32). The temperature sensor (31) is installed on the front side of the top surface of the sealing cover (7). The temperature controller (35) is fixed on the front side of the left frame (4). The input end of the heating tube (34) is electrically connected to the output end of the temperature controller (35). The input end of the temperature controller (35) is electrically connected to the output end of the controller (18). The output end of the temperature sensor (31) is electrically connected to the input end of the controller (18).

4. The reaction apparatus for preparing cross-linked sodium hyaluronate according to claim 1, characterized in that: It also includes a secondary linear motor (11), a placement plate (12), and a limiting clamp (13). There are two secondary linear motors (11), which are respectively fixed in the grooves on the top surface of the base plate (1). The top surface of the moving part of the secondary linear motor (11) is connected to one side of the bottom surface of the placement plate (12). The top surface of the placement plate (12) is provided with two corresponding limiting clamps (13). The input end of the secondary linear motor (11) is electrically connected to the output end of the controller (18).

5. The reaction apparatus for preparing cross-linked sodium hyaluronate according to claim 1, characterized in that: It also includes an electric telescopic rod (14), a box frame (15) and a cleaning box (16). There are two electric telescopic rods (14) and they are fixed to the rear sides of the corresponding two frames (4). The front end of the electric telescopic rod (14) is connected to one end of the rear side of the box frame (15). The cleaning box (16) is inserted into the box frame (15). The input end of the electric telescopic rod (14) is electrically connected to the output end of the controller (18).

6. The reaction apparatus for preparing cross-linked sodium hyaluronate according to claim 1, characterized in that: It also includes a display screen (17), which is fixed to the top of the front side of the right frame (4), and the input end of the display screen (17) is electrically connected to the output end of the controller (18).

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