An ester exchange reaction device for producing trimebutine maleate

Abstract

The utility model relates to the technical field of chemical equipment, concretely relates to a kind of transesterification reaction device for maleic acid trimebutine production, including foundation, the top middle of the foundation is provided with reaction mechanism, the top outside of the foundation is provided with control mechanism, the reaction mechanism includes placing rack, the bottom of the placing rack is fixedly connected in the top middle of the foundation, the top of the placing rack is fixedly connected with reaction kettle, the top of the reaction kettle is threadedly connected with kettle cover, the top of the kettle cover is fixedly connected with speed regulating motor, the output of the speed regulating motor is fixedly connected with stirrer;The utility model, by the power output of speed regulating motor, drive stirrer to rotate in reaction kettle, promote reactant to mix fully, to realize the omnidirectional mixing of reactant in reaction kettle and the sustained disturbance of bottom material, both promote the mass transfer heat transfer efficiency between material, also avoid the problem of insufficient reaction caused by bottom material deposition.

Description

Technical Field

[0001] This utility model relates to the field of chemical equipment technology, and in particular to an ester exchange reaction device for the production of trimebutine maleate. Background Technology

[0002] Trimebutine maleate is a commonly used Western medicine suitable for treating symptoms such as loss of appetite, nausea, vomiting, belching, bloating, abdominal pain, diarrhea, and constipation caused by gastrointestinal dysfunction. It can also be used for irritable bowel syndrome. With the increasing number of patients with gastrointestinal diseases, the demand for trimebutine maleate is also constantly increasing. This necessitates efficient and high-quality production processes and corresponding reaction equipment to meet market demand. The synthesis of trimebutine alkaloids is one of the key steps in the synthesis of trimebutine maleate.

[0003] Existing technology patent document CN219356255U discloses a rapid reaction device for transesterification, belonging to the field of chemical equipment technology. This device includes a storage tank, a condenser, a vacuum system, a tail gas treatment system, a circulating pump, a reboiler directly above the storage tank, and a mist distributor located in the upper part of the storage tank, all connected sequentially by pipelines. The storage tank is equipped with a first heating jacket; the reboiler is equipped with a second heating jacket, and the temperature inside the reboiler is 2-5°C lower than the temperature inside the storage tank. The mist distributor is located above the reaction liquid and away from the exhaust port at the top of the storage tank. The lower part of the storage tank, the reboiler, and the mist distributor are connected sequentially by a circulation pipe with a circulating pump. This device can significantly reduce the transesterification reaction time, improve reaction efficiency, and reduce energy consumption. Specifically, the reaction time for the transesterification reaction of ethyl para-aminobenzoate and isooctyl alcohol can be reduced to approximately 12 hours. Furthermore, this device has a simple structure and is easy to maintain.

[0004] While the above method achieves a simple device structure and ease of maintenance, it is difficult to achieve uniform mixing of materials within the reactor during the reaction process. This results in significant differences in material concentration and temperature in different areas, affecting the consistency and completeness of the reaction. Furthermore, materials tend to deposit at the bottom of the reactor, creating localized areas of excessively high concentration, hindering effective contact between reactants and the reaction process. This slows down the reaction rate and reduces efficiency. Ultimately, these problems lead to low product conversion rates and incomplete reactions, increasing energy and raw material consumption, and easily introducing impurities, affecting the quality and yield of trimebutine maleate, making it difficult to meet the ever-increasing production demands and quality requirements. Utility Model Content

[0005] The purpose of this invention is to provide an ester exchange reaction device for the production of trimebutine maleate, aiming to solve the problems of low reaction efficiency, low product conversion rate, and incomplete reaction caused by uneven material mixing and bottom material deposition in the reaction device.

[0006] To achieve the above objectives, this utility model provides a transesterification reaction apparatus for the production of trimebutine maleate, comprising a foundation, a reaction mechanism disposed at the top center of the foundation, and a control mechanism disposed at the top outer side of the foundation. The reaction mechanism includes a placement frame, the bottom of which is fixedly connected to the top center of the foundation, and a reaction vessel fixedly connected to the top of the placement frame. A vessel cover is threadedly connected to the top of the reaction vessel, and a speed-regulating motor is fixedly connected to the top of the vessel cover. A stirrer is fixedly connected to the output end of the speed-regulating motor, a movable rod is fixedly connected to the bottom of the stirrer, and a bottom scraper is fixedly connected to the bottom outer side of the movable rod. A docking assembly is fixedly connected to the bottom left side of the reaction vessel, and an injection assembly is fixedly connected to the bottom right side of the reaction vessel.

[0007] The control mechanism includes a transfer pipe, the bottom of which is fixedly connected to the top left side of the foundation. A converter is fixedly connected to the top of the transfer pipe. An electromagnetic heating tube is fixedly connected inside the converter. A booster is fixedly connected to the top of the converter. A volume control tank is fixedly connected to the top right side of the foundation. A liquid pump is fixedly connected to the output end of the volume control tank.

[0008] A cooler is fixedly connected to the top of the foundation, and multiple heat dissipation fins are fixedly connected inside the cooler. A collection pipe is fixedly connected to the output end of the cooler.

[0009] The docking assembly includes a side interface, one end of which is fixedly connected to the bottom left side of the reactor, and a top interface is fixedly connected to the top left side of the reactor lid.

[0010] The injection assembly includes a side outlet, one end of which is fixedly connected to the bottom right side of the reactor, and a top inlet is fixedly connected to the top right side of the reactor lid.

[0011] The other end of the side interface is threaded to the receiving end of the adapter pipe, and the other end of the top interface is threaded to the output end of the booster.

[0012] The other end of the side outlet is threaded to the receiving end of the volume control tank, and the other end of the top inlet is threaded to the output end of the liquid pump.

[0013] The receiving end of the cooler is fixedly connected to the bottom of the reactor, and the bottom of the collecting pipe is fixedly connected to the top right side of the foundation.

[0014] This utility model relates to an ester exchange reaction apparatus for the production of trimebutine maleate.

[0015] 1. In this utility model, the speed-regulating motor outputs power to drive the stirrer to rotate inside the reactor, promoting thorough mixing of the reactants. The stirrer is connected to a movable rod at the bottom, which drives the bottom scraper to move closely against the bottom of the reactor, preventing material deposition. This achieves all-round mixing of the reactants in the reactor and continuous disturbance of the bottom material, which not only promotes the efficiency of mass and heat transfer between materials, but also avoids the problem of incomplete reaction caused by bottom material deposition. Ultimately, it ensures that the transesterification reaction is carried out efficiently in a uniform and dead-angle-free environment, improving the conversion rate of the product and the integrity of the reaction.

[0016] 2. In this utility model, the electromagnetic heating tube in the converter heats the material input through the converter tube, which drives the booster to input the heated material into the reactor through the top interface. The reactor is connected to the cooler at the bottom, which drives the high-temperature product into the cooler. The heat dissipation area is increased by using heat dissipation fins to solve the problems that the material temperature cannot meet the reaction conditions and that the high-temperature product after the reaction is difficult to cool down to a suitable processing temperature quickly. Attached Figure Description

[0017] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the accompanying drawings used in the description of the embodiments or the prior art will be briefly introduced below.

[0018] Figure 1 This is a schematic diagram of the overall structure of an ester exchange reaction device for the production of trimebutine maleate according to this utility model.

[0019] Figure 2 This is a schematic diagram of the reaction vessel of a transesterification reaction device for producing trimebutine maleate according to this utility model.

[0020] Figure 3 This is a schematic diagram of the converter in a transesterification reaction device for the production of trimebutine maleate according to this utility model.

[0021] Figure 4 This is a schematic diagram of the structure of the stirrer in a transesterification reaction device for the production of trimebutine maleate according to this utility model.

[0022] 1-Foundation; 2-Reaction mechanism; 21-Placement rack; 22-Reaction vessel; 23-Vessel cover; 24-Speed-regulating motor; 25-Agitator; 26-Moving rod; 27-Bottom scraper; 28-Connecting assembly; 281-Side interface; 282-Top interface; 29-Injection assembly; 291-Side outlet; 292-Top inlet; 3-Control mechanism; 31-Transfer pipe; 32-Converter; 33-Electromagnetic heating tube; 34-Pressure booster; 35-Quantity control tank; 36-Liquid pump; 37-Cooler; 38-Heat dissipation fins; 39-Collection pipe. Detailed Implementation

[0023] The embodiment of this application is as follows:

[0024] Please see Figure 1 , Figure 2 and Figure 4 , one The transesterification reaction device for producing trimebutine maleate includes a foundation 1, which provides a stable installation platform to ensure the device remains stable during operation. A reaction mechanism 2 is located in the middle of the top of the foundation 1, and a control mechanism 3 is located on the outer side of the top of the foundation 1.

[0025] The reaction mechanism 2 includes a support frame 21, which supports and fixes the reaction vessel 22, ensuring it is at a suitable height and position. The bottom of the support frame 21 is fixedly connected to the top center of the foundation 1, and the top of the support frame 21 is fixedly connected to the reaction vessel 22. The reaction vessel 22 is the core container for the transesterification reaction in the production of trimebutine maleate, providing a specific space and environment for the reaction to carry out the chemical reaction within it. The top of the reaction vessel 22 is threadedly connected to a lid 23, which seals the reaction vessel 22 to prevent material evaporation and leakage during the reaction. A speed-regulating motor 24 is fixedly connected to the top of the lid 23, providing power to the stirrer 25 and allowing adjustment of the stirring speed according to reaction requirements to promote thorough mixing of reactants and accelerate the reaction rate. The speed-regulating motor 24... A stirrer 25 is fixedly connected to the outlet end. Driven by a speed-regulating motor 24, the stirrer 25 stirs the material in the reactor 22, promotes mass and heat transfer between materials, and makes the reaction more complete. A movable rod 26 is fixedly connected to the bottom of the stirrer 25. The movable rod 26 connects the stirrer 25 and the bottom scraper 27, and transmits the rotational motion of the stirrer 25 to the bottom scraper 27. At the same time, it plays a buffering and regulating role to a certain extent. The bottom scraper 27 is fixedly connected to the outer side of the bottom of the movable rod 26. The bottom scraper 27 is close to the bottom of the reactor 22 and rotates under the drive of the movable rod 26 to scrape off the material at the bottom of the reactor 22, prevent material deposition, and ensure that the reaction is complete. A docking assembly 28 is fixedly connected to the bottom left side of the reactor 22, and an injection assembly 29 is fixedly connected to the bottom right side of the reactor 22.

[0026] The docking assembly 28 includes a side interface 281, which serves as one of the interfaces connecting the reactor 22 to external equipment for material output. One end of the side interface 281 is fixedly connected to the bottom left side of the reactor 22. A top interface 282 is fixedly connected to the top left side of the reactor cover 23. The top interface 282 also serves as an interface connecting the reactor 22 to external equipment, mainly for connecting to the booster 34 to achieve material input. The injection assembly 29 includes a side outlet 291, which is used to discharge the reaction products or intermediate products in the reactor 22 and transport them to subsequent processing equipment. One end of the side outlet 291 is fixedly connected to the bottom right side of the reactor 22. A top inlet 292 is fixedly connected to the top right side of the reactor cover 23. The top inlet 292 serves as one of the inlets for materials to enter the reactor 22, for injecting reactants or other auxiliary materials into the reactor 22.

[0027] Please see Figures 1 to 3 The control mechanism 3 includes a transfer pipe 31, which connects the side interface 281 of the reactor 22 and the converter 32, serving as a material transfer channel. The bottom of the transfer pipe 31 is fixedly connected to the top left side of the foundation 1, and the top of the transfer pipe 31 is fixedly connected to the converter 32. The converter 32 heats the material entering through the transfer pipe 31, providing the required temperature conditions for the transesterification reaction. An electromagnetic heating tube 33 is fixedly connected inside the converter 32. The electromagnetic heating tube 33, as the core heating component of the converter 32, generates heat through electromagnetic induction to heat the material. A pressure booster 34 is fixedly connected to the top of the converter 32. The pressure booster 34 regulates the pressure inside the reactor 22, providing a suitable pressure environment for the transesterification reaction, promoting the reaction and increasing the product yield. The top right side of the foundation 1... A flow control tank 35 is fixedly connected to the reactor. The flow control tank 35 stores and measures the materials required for the reaction, controls the input and output of materials, and ensures the accurate addition of materials and quantitative collection of products during the reaction process. A liquid pump 36 is fixedly connected to the output end of the flow control tank 35. The liquid pump 36 provides power to realize the transportation of materials in the reaction device. A cooler 37 is fixedly connected to the top of the foundation 1. The cooler 37 cools the high-temperature materials discharged from the reactor 22, reduces the material temperature, and makes it meet the requirements for subsequent processing or storage. Multiple heat dissipation fins 38 are fixedly connected inside the cooler 37. The heat dissipation fins 38 increase the heat dissipation area of ​​the cooler 37, improve the cooling efficiency, and accelerate the dissipation of heat from the materials. A collection pipe 39 is fixedly connected to the output end of the cooler 37. The collection pipe 39 collects the materials cooled by the cooler 37.

[0028] The other end of the side interface 281 is threaded to the receiving end of the adapter pipe 31, the other end of the top interface 282 is threaded to the output end of the booster 34, the other end of the side outlet 291 is threaded to the receiving end of the flow control tank 35, the other end of the top inlet 292 is threaded to the output end of the liquid pump 36, the receiving end of the cooler 37 is fixedly connected to the bottom of the reactor 22, and the bottom of the collection pipe 39 is fixedly connected to the top right side of the foundation 1.

[0029] In this specific embodiment, during the material input and reaction process, reactants or auxiliary materials are injected into the reactor from the control tank 35 via the top inlet 292 through the liquid pump 36. The control tank 35 can accurately measure the materials. The speed-regulating motor 24 drives the stirrer 25, which in turn drives the bottom scraper 27 through the movable rod 26 to stir the materials in the reactor and scrape off the bottom materials. At the same time, external materials enter the converter 32 through the side interface 281 and the connected transfer pipe 31. After the electromagnetic heating tube 33 heats the materials, they are input into the reactor through the top interface 282 by the pressure booster 34. The pressure booster 34 can also adjust the pressure inside the reactor to provide a suitable environment for the reaction.

[0030] After the reaction is completed, the high-temperature reaction products are discharged from the bottom of the reactor into the cooler 37. The heat dissipation fins 38 increase the heat dissipation area and efficiently cool the materials. The cooled materials are collected through the collection pipe 39. Throughout the process, the foundation 1 and the placement rack 21 provide stable support for the reactor, and the reactor cover 23 provides a sealed environment for the reactor to ensure the smooth progress of the reaction.

[0031] The above-disclosed embodiments are merely one or more preferred embodiments of this application and should not be construed as limiting the scope of this application. Those skilled in the art can understand that implementing all or part of the above embodiments and making equivalent changes in accordance with the claims of this application still fall within the scope of this application.

Claims

1. A transesterification reactor for the production of trimebutine maleate, comprising a foundation, characterized in that, A reaction mechanism is provided at the top center of the foundation, and a control mechanism is provided on the top outer side of the foundation. The reaction mechanism includes a placement frame, the bottom of which is fixedly connected to the top center of the foundation. A reaction vessel is fixedly connected to the top of the placement frame, and a vessel lid is threadedly connected to the top of the reaction vessel. A speed-regulating motor is fixedly connected to the top of the vessel lid, and a stirrer is fixedly connected to the output end of the speed-regulating motor. A movable rod is fixedly connected to the bottom of the stirrer, and a bottom scraper is fixedly connected to the outer side of the bottom of the movable rod. A docking assembly is fixedly connected to the bottom left side of the reaction vessel, and an injection assembly is fixedly connected to the bottom right side of the reaction vessel.

2. The transesterification apparatus for producing trimebutine maleate as described in claim 1, characterized in that, The control mechanism includes a transfer pipe, the bottom of which is fixedly connected to the top left side of the foundation. A converter is fixedly connected to the top of the transfer pipe. An electromagnetic heating tube is fixedly connected inside the converter. A booster is fixedly connected to the top of the converter. A volume control tank is fixedly connected to the top right side of the foundation. A liquid pump is fixedly connected to the output end of the volume control tank.

3. The transesterification apparatus for producing trimebutine maleate as described in claim 2, characterized in that, A cooler is fixedly connected to the top of the foundation, and multiple heat dissipation fins are fixedly connected inside the cooler. A collection pipe is fixedly connected to the output end of the cooler.

4. The transesterification apparatus for producing trimebutine maleate as described in claim 3, characterized in that, The docking assembly includes a side interface, one end of which is fixedly connected to the bottom left side of the reactor, and a top interface is fixedly connected to the top left side of the reactor lid.

5. The transesterification apparatus for producing trimebutine maleate as described in claim 4, characterized in that, The injection assembly includes a side outlet, one end of which is fixedly connected to the bottom right side of the reactor, and a top inlet is fixedly connected to the top right side of the reactor lid.

6. The transesterification apparatus for producing trimebutine maleate as described in claim 5, characterized in that, The other end of the side interface is threaded to the receiving end of the adapter pipe, and the other end of the top interface is threaded to the output end of the booster.

7. The transesterification apparatus for producing trimebutine maleate as described in claim 6, characterized in that, The other end of the side outlet is threaded to the receiving end of the volume control tank, and the other end of the top inlet is threaded to the output end of the liquid pump.

8. The transesterification apparatus for producing trimebutine maleate as described in claim 7, characterized in that, The receiving end of the cooler is fixedly connected to the bottom of the reactor, and the bottom of the collecting pipe is fixedly connected to the top right side of the foundation.

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