Integrated all-in-one full-automatic liquid chromatograph

Abstract

The utility model discloses an integrated type integral full -automatic liquid chromatograph, including integral machine case, integral machine case top is equipped with solvent placing groove, and integral machine case inside is equipped with first baffle, second baffle from below to top in proper order, third baffle, and the both sides of first baffle, second baffle and third baffle are equipped with the interface mounting bracket that passes through bolt nut connection, and both sides mounting bracket fixed connection in integral machine case inner wall, one side on first baffle, second baffle, third baffle is equipped with pump integrated module, syringe module, detection cell module, and integral machine case inboard has chromatographic column installation groove.

Description

Technical Field

[0001] This utility model belongs to the field of liquid chromatography technology, and more specifically, it relates to an integrated fully automated liquid chromatograph. Background Technology

[0002] Liquid chromatographs (LCs) consist of a high-pressure pump, an injection system, a temperature control system, a chromatographic column, a detector, and a signal recording system, depending on whether the stationary phase is liquid or solid. Compared with classic liquid column chromatography devices, LCs are characterized by high efficiency, speed, and sensitivity. During separation operations, LCs involve a wide variety of mobile phases, such as formic acid, acetic acid, and perchloric acid in aqueous phases, and methanol, acetonitrile, dichloromethane, and DMF in organic phases. The main waste liquids collected in chromatography are those generated after the adsorption and separation of the mobile phase and liquid samples in the chromatographic column.

[0003] However, existing liquid chromatographs generally have a modular structure, with each module having relatively independent functions, making operation cumbersome. The installation and maintenance of internal functional modules are time-consuming and labor-intensive, and the temperature control consistency between the chromatographic column and the internal chamber is poor, which can easily affect the accuracy of detection. Utility Model Content

[0004] To address the shortcomings of existing technologies, this invention provides an integrated, fully automated liquid chromatograph to solve the problems mentioned in the background section.

[0005] To achieve the above objectives, this utility model provides the following technical solution: an integrated fully automated liquid chromatograph, comprising an overall chassis, a solvent placement tank on the top of the chassis, and a first partition, a second partition, and a third partition arranged sequentially from bottom to top inside the chassis. Sliding mounting brackets are provided on both sides of the first, second, and third partitions, and these mounting brackets are fixedly connected to the inner wall of the overall chassis. A pump integration module, a syringe module, and a detection cell module are provided on one side of the first, second, and third partitions. A temperature control baffle hinged to the overall chassis is provided in the column mounting slot. A temperature control component is provided within the column mounting slot, comprising a heat insulation plate installed within the column mounting slot, a sealing heat insulation strip at the connection between the heat insulation plate and the inner wall of the overall chassis, a circulating fan on one side of the column mounting slot, and a heating element within the column mounting slot. A heat-absorbing aluminum plate is embedded in the inner surface of the temperature control baffle.

[0006] Preferably, the column mounting slot and the overall chassis are respectively equipped with a first temperature sensor and a second temperature sensor, and the overall chassis is also equipped with a circuit board that is connected to the first temperature sensor and the second temperature sensor for control.

[0007] Preferably, the surface of the chassis is also equipped with a cooling fan.

[0008] Preferably, the overall chassis has a hinged integrated door on its surface, an electronic display screen on the surface of the integrated door, and an observation window below the electronic display screen.

[0009] Preferably, the column mounting groove is further provided with a column selection valve, which has several mounting ports.

[0010] Preferably, the material of the sealing and heat insulation strip is silicone.

[0011] Preferably, the pump integration module includes a first pump group, a second pump group, a plunger cleaning pump, and an online degasser that are interconnected.

[0012] Preferably, the syringe module includes a syringe, a mixer connected to the syringe, and a high-pressure six-way valve.

[0013] This utility model provides an integrated, fully automated liquid chromatograph, which has the following advantages: This integrated fully automated liquid chromatograph integrates all functional modules through an internal drawer-type design, making it more convenient and labor-saving to use and debug. The internal detachable connection installation makes subsequent maintenance and repair more convenient and labor-saving, thereby improving overall work efficiency.

[0014] This integrated fully automated liquid chromatograph is equipped with a column switching valve, which can install multiple chromatographic columns and automatically switch between different types of chromatographic columns required for detection through a pre-set program. This greatly simplifies the replacement operation steps, reduces the replacement operation time, and improves work efficiency.

[0015] This integrated fully automated liquid chromatograph can ensure the uniformity and consistency of the internal and external temperatures of the chromatographic column through an internal temperature control component, accurately control the column temperature, and ensure the stability and repeatability of the analysis process. The overall temperature control effect is between 5℃ and 115℃.

[0016] 4. By setting up an integrated pump module, stable pressure and flow rate can be provided to ensure that the mobile phase can pass through the chromatographic column uniformly, thereby achieving sample separation. The online degasser can prevent the influence of air bubbles in the pump and avoid the mobile phase flowing around in the chromatographic column, ensuring the accuracy and stability of detection. Attached Figure Description

[0017] Figure 1 This is a schematic diagram of the overall structure of this utility model.

[0018] Figure 2 This is a schematic diagram of the internal structure of this utility model.

[0019] Figure 3This is a schematic diagram of the internal structure of this utility model.

[0020] Figure 4 This is a schematic diagram of the installation of the functional modules of this utility model.

[0021] Figure 5 This is a schematic diagram of the installation of the heat insulation board and sealing heat insulation strip of this utility model.

[0022] In the diagram: 1. Overall chassis; 2. Solvent placement tank; 3. First partition; 4. Second partition; 5. Third partition; 6. Pump integrated module; 7. Syringe module; 8. Detection cell module; 9. Column mounting slot; 10. Temperature control baffle; 11. Temperature control component; 1101. Heat insulation plate; 1102. Sealing heat insulation strip; 1103. Circulating fan; 1104. Heat-absorbing aluminum plate; 12. First temperature sensor; 13. Second temperature sensor; 14. Circuit board; 15. Integrated door; 16. Observation window; 17. Electronic display screen; 18. Cooling fan; 19. Column selection valve; 20. Mounting bracket; 21. First pump set; 22. Second pump set; 23. Plunger cleaning pump; 24. Online degasser; 25. Syringe; 26. Mixer; 27. High-pressure six-way valve. Detailed Implementation

[0023] The embodiments of this utility model will be described in further detail below with reference to the accompanying drawings and examples. The following examples are for illustrative purposes only and should not be construed as limiting the scope of this utility model.

[0024] In the description of this utility model, unless otherwise stated, "a plurality of" means two or more; the terms "upper," "lower," "left," "right," "inner," "outer," "front end," "rear end," "head," "tail," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model. In addition, the terms "first," "second," "third," etc., are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0025] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "connected" and "linked" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0026] Please see Figures 1 to 4This utility model provides a technical solution: an integrated fully automated liquid chromatograph, including an overall chassis 1. A solvent placement tank 2 is located on the top of the overall chassis 1. Inside the overall chassis 1, from bottom to top, are arranged a first partition 3, a second partition 4, and a third partition 5. Sliding mounting brackets 20 are provided on both sides of the first partition 3, second partition 4, and third partition 5, and the mounting brackets 20 are fixedly connected to the inner wall of the overall chassis 1. A pump integration module 6, a syringe module 7, and a detection cell module 8 are provided on one side of the first partition 3, second partition 4, and third partition 5. The pump integration module 6 includes a first pump group, a second pump group, a plunger cleaning pump, and an online degasser, all interconnected. The syringe module 7 includes a syringe 25, a mixer 26 connected to the syringe 25, and a high-pressure six-way valve 27. The inner side of the overall chassis 1 has a column mounting slot 9; the outer side of the column mounting slot 9 is equipped with a temperature control baffle 10 hinged to the overall chassis 1. A temperature control component 11 is installed inside the column mounting slot 9. The temperature control component 11 includes a heat insulation plate 1101 installed inside the column mounting slot 9, a sealing heat insulation strip 1102 located at the connection between the heat insulation plate 1101 and the inner wall of the overall chassis 1, a circulating fan 1103 located on one side of the column mounting slot 9, and a heating element located inside the column mounting slot 9. A heat-absorbing aluminum plate 1104 is embedded on the inner surface of the temperature control baffle 10. A column selection valve 19 is also installed inside the column mounting slot 9, and the column selection valve 19 has several mounting ports. A first temperature sensor 12 and a second temperature sensor 13 are respectively installed inside the column mounting slot 9 and the overall chassis 1. A circuit board 14 connected to the first temperature sensor 12 and the second temperature sensor 13 is also installed inside the overall chassis 1.

[0027] The chassis 1 has a hinged, integrated door 15 on its surface, an electronic display screen 17 on its surface, and an observation window 16 below the electronic display screen 17. The chassis 1 also has a cooling fan 18 on its surface.

[0028] The specific usage and function of this embodiment: This integrated fully automatic liquid chromatograph has a drawer-type internal design, which allows the pump integration module 6, syringe module 7, and detection cell module 8 to be installed in advance and then placed in the respective partitions, making it more convenient and labor-saving to use and debug. The internal detachable connection installation makes subsequent maintenance and repair more convenient and labor-saving. The overall layout is reasonable and reliable, which facilitates the integration of various functional modules. The staff can also easily operate and control the internal components through the electronic display screen 17, which significantly improves the overall work efficiency.

[0029] It is equipped with a column selection valve 19, which can install multiple chromatographic columns. It can also automatically switch between different types of chromatographic columns required for different samples (water, milk, blood, etc.) through a pre-set program, which greatly simplifies the replacement operation steps, reduces the replacement operation time, and improves work efficiency.

[0030] The temperature control component 11 can regulate and control the temperature of the chromatographic column surface. The internal temperature is increased by the heating element 1104, and then the circulating fan 1103 works to agitate the internal air, so that the overall temperature is kept consistent, improving the temperature control uniformity between the inside and outside of the chromatographic column. At the same time, the heat-absorbing aluminum plates 1104 on both sides absorb heat, further ensuring the consistency of internal heat, thereby accurately controlling the temperature of the chromatographic column and ensuring the stability and repeatability of the analysis process. The overall temperature control effect is between 5℃ and 115℃.

[0031] The pump integration module, through the first pump group 21, the second pump group 22, and the plunger cleaning pump 23, can provide stable pressure and flow rate, ensuring that the mobile phase can pass through the chromatographic column uniformly, thereby achieving sample separation. The online degasser 24 can prevent the influence of air bubbles in the pump, avoid the mobile phase from flowing around in the chromatographic column, and ensure the accuracy and stability of detection.

[0032] The syringe 25 in syringe module 7 enables stable sample injection, and then the multi-component solvent is mixed in a low-pressure gradient system by mixer 26, while the high-pressure six-way valve 27 enables stable and precise sample injection.

[0033] The above description is only a preferred embodiment of the present utility model, but the protection scope of the present utility model is not limited thereto. Any equivalent substitutions or changes made by those skilled in the art within the technical scope disclosed in the present utility model, based on the technical solution and the inventive concept of the present utility model, should be included within the protection scope of the present utility model.

Claims

1. An integrated fully automated liquid chromatograph, comprising an integrated chassis (1), wherein the top of the integrated chassis (1) is provided with a solvent placement tank (2), characterized in that: The interior of the integrated chassis (1) is provided with a first partition (3), a second partition (4), and a third partition (5) from bottom to top. Sliding mounting brackets (20) are provided on both sides of the first partition (3), second partition (4), and third partition (5), and the mounting brackets (20) on both sides are fixedly connected to the inner wall of the integrated chassis (1). A pump integration module (6), a syringe module (7), and a detection cell module (8) are sequentially provided on the first partition (3), second partition (4), and third partition (5). A chromatographic column mounting groove (9) is located on the inner side of the integrated chassis (1). The column mounting slot (9) is provided with a temperature control baffle (10) hinged to the overall chassis (1). The column mounting slot (9) is provided with a temperature control component (11). The temperature control component (11) includes a heat insulation plate (1101) installed in the column mounting slot (9), a sealing heat insulation strip (1102) located at the connection between the heat insulation plate (1101) and the inner wall of the overall chassis (1), a circulating fan (1103) located on one side of the column mounting slot (9), and a heating element located in the column mounting slot (9). The inner surface of the temperature control baffle (10) is embedded with a heat-absorbing aluminum plate (1104).

2. The integrated fully automated liquid chromatograph according to claim 1, characterized in that: The column mounting slot (9) and the overall chassis (1) are respectively equipped with a first temperature sensor (12) and a second temperature sensor (13). The overall chassis (1) is also equipped with a circuit board (14) that is connected to the first temperature sensor (12) and the second temperature sensor (13) for control.

3. The integrated fully automated liquid chromatograph according to claim 1, characterized in that: The surface of the chassis (1) is also equipped with a cooling fan (18).

4. The integrated fully automated liquid chromatograph according to claim 1, characterized in that: The overall chassis (1) has a hinged integrated door (15) on its surface, and an electronic display screen (17) is provided on the surface of the integrated door (15). An observation window (16) is provided below the electronic display screen (17).

5. The integrated fully automated liquid chromatograph according to claim 1, characterized in that: The column mounting groove (9) is also provided with a column selection valve (19), and the surface of the column selection valve (19) is provided with several mounting ports.

6. The integrated fully automated liquid chromatograph according to claim 1, characterized in that: The sealing and heat insulation strip (1102) is made of silicone.

7. The integrated fully automated liquid chromatograph according to claim 1, characterized in that: The pump integration module (6) includes a first pump group (21), a second pump group (22), a plunger cleaning pump (23), and an online degasser (24) that are interconnected.

8. The integrated fully automated liquid chromatograph according to claim 1, characterized in that: The syringe module (7) includes a syringe (25), a mixer (26) connected to the syringe (25), and a high-pressure six-way valve (27).

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