A cleaning system for plastic ampoule suspension and true solution co-linear production

Abstract

The utility model relates to the technical field of medicament pipeline cleaning, disclose a kind of cleaning system of plastic ampoule suspension solution and true solution collinear production, including cleaning tank and mandrel cover, the cleaning medium in the cleaning tank is entered mandrel cover after passing through the pipeline of production system, mandrel cover can discharge its inside cleaning medium, still including injection water tank, ethanol circulation pipeline and nitrogen pipeline, the injection water in injection water tank can be entered mandrel cover after passing through the pipeline of production system, ethanol circulation pipeline is connected mandrel cover and cleaning tank, nitrogen pipeline is connected ethanol circulation pipeline, nitrogen in nitrogen pipeline can be purged to ethanol circulation pipeline.The utility model is through to the structure and pipeline of current cleaning station are reformed optimization, so that cleaning station simultaneously has the function of water washing and ethanol cleaning, to allow the existing automatic liquid preparation liquid system and blow-filling-seal integrated machine can be used to produce true solution ampoule, also can be used to produce suspension solution ampoule, with collinear production capacity.

Description

Technical Field

[0001] The utility model relates to the technical field of cleaning of pharmaceutical pipelines, and particularly relates to a cleaning system for co-linear production of plastic ampoule suspension and true solution. Background Art

[0002] At the current stage, the automatic liquid preparation pharmaceutical solution system and the blow-fill-seal integrated machine for producing plastic ampoules only produce true solution ampoules. Therefore, the cleaning station and the related cleaning pipelines supporting them only have the ability to clean the related tanks and pipelines with purified water.

[0003] As shown in the appendix Figure 1 During the production process, valve c is closed, and the pharmaceutical solution in the preparation tank 1 sequentially enters the balance tank 3 through valve a and valve b. The balance tank 3 has the function of regulating pressure and stabilizing voltage. The liquid medicine in the balance tank 3 enters the filling needle 4 and finally enters the plastic ampoule bottle. When the equipment pipeline needs to be cleaned, valve a is closed, and the purified water in the cleaning tank 2 sequentially enters the balance tank 3 through valve c and valve b, and then enters the filling needle 4. A mandrel cover 5 is arranged below the filling needle 4, and the flushing water flowing out of the filling needle 4 enters the mandrel cover 5 and can be directly discharged through valve d.

[0004] However, when producing suspension, since the suspension is insoluble in water, the equipment and pipelines after producing the suspension cannot meet the cleaning requirements only by water washing. A large amount of ethanol needs to be used to clean the pipelines. Ethanol cannot be directly discharged during the cleaning process. Ethanol needs to be used to circulate and clean the pipelines, and the ethanol needs to be collected after cleaning. Due to the single function of the cleaning station, the existing equipment cannot produce plastic ampoules of suspension, so it needs to be improved. Content of the Utility Model

[0005] Aiming at the problems existing in the prior art: the cleaning station supporting the existing automatic liquid preparation pharmaceutical solution system and the blow-fill-seal integrated machine only has the function of water washing, resulting in the existing equipment being unable to produce plastic ampoules of suspension. The purpose of the utility model is to provide a cleaning system for co-linear production of plastic ampoule suspension and true solution. By reforming and optimizing the structure and pipelines of the current cleaning station, the cleaning station simultaneously has the functions of water washing and ethanol cleaning, so that the existing automatic liquid preparation pharmaceutical solution system and the blow-fill-seal integrated machine can be used to produce both true solution ampoules and suspension ampoules, and have the co-linear production ability.

[0006] To achieve the above purpose, the technical solution of the utility model is as follows: A cleaning system for co-production of plastic ampoule suspension and true solution includes a cleaning tank and a mandrel housing. The cleaning medium in the cleaning tank enters the mandrel housing through the production system pipeline. The mandrel housing can discharge the cleaning medium inside. The system also includes an injection water tank, an ethanol circulation pipeline, and a nitrogen pipeline. The injection water in the injection water tank enters the mandrel housing through the production system pipeline. The ethanol circulation pipeline connects the mandrel housing and the cleaning tank. The nitrogen pipeline connects to the ethanol circulation pipeline, and the nitrogen in the nitrogen pipeline can purge the ethanol circulation pipeline.

[0007] The present invention is further configured such that: the cleaning tank is also provided with a cleaning return pipeline, the production system includes a preparation tank, the preparation tank is provided with a suspension circulation pipeline, and the cleaning medium in the cleaning tank can enter the suspension circulation pipeline and return to the cleaning tank through the cleaning return pipeline.

[0008] The present invention is further configured such that: valve a and valve e are provided on the suspension circulation pipeline, valve a is located at the end of the suspension circulation pipeline for conveying the cleaning medium, and valve e is located at the liquid inlet end of the suspension circulation pipeline; in the suspension circulation pipeline, the suspension in the preparation tank passes through valve a and valve e in sequence; the cleaning medium in the cleaning tank enters the suspension circulation pipeline from a position close to valve a and downstream of valve a; and the connection position between the cleaning return pipeline and the suspension circulation pipeline is located close to valve e and upstream of valve e.

[0009] The present invention is further configured such that: a valve g is provided between the mandrel cover and the ethanol circulation pipeline, the connection point between the nitrogen pipeline and the ethanol circulation pipeline is located downstream of and close to the valve g, and the valve g is closed when the nitrogen in the nitrogen pipeline purges the ethanol circulation pipeline.

[0010] The present invention is further configured such that: the pipeline for supplying cleaning medium from the injection water tank to the production system is connected to the pipeline for supplying cleaning medium from the cleaning tank to the production system, and a valve m is provided on the pipeline for supplying cleaning medium from the cleaning tank to the production system, and a valve k is provided on the pipeline for supplying cleaning medium from the injection water tank to the production system.

[0011] The present invention is further configured such that: valve m is opened when the cleaning tank delivers the cleaning medium to the production system and closed when the injection water tank delivers the cleaning medium to the production system; and valve k is closed when the cleaning tank delivers the cleaning medium to the production system and opened after the cleaning tank has finished delivering the cleaning medium to the production system.

[0012] The present invention is further configured such that: a valve c is provided on the pipeline from the injection water tank and the cleaning tank to the production system for conveying the cleaning medium, and the valve c is closed during the operation of the production system.

[0013] In summary, the beneficial effects achieved by this utility model are as follows: (1) An ethanol circulation pipeline connecting the mandrel cover and the cleaning tank was added to the original cleaning station. When the cleaning medium in the cleaning tank is changed from purified water to ethanol, the ethanol can clean the production system along the pipeline of the original cleaning station. When the ethanol enters the mandrel cover, the mandrel cover does not directly discharge the ethanol but sends the ethanol back to the cleaning tank through the ethanol circulation pipeline, thereby realizing the circulation cleaning of the production system and also achieving the purpose of collecting ethanol. (2) An injection water tank and a nitrogen pipeline were added to the original cleaning station. After the pipelines of the production system were cleaned with ethanol, the circulation pump in the pipeline was shut down. However, some ethanol still remained in the pipelines of the production system and the ethanol circulation pipeline. At this time, the nitrogen pipeline could be connected to the ethanol circulation pipeline, and the nitrogen in the nitrogen pipeline could be used to purge the ethanol circulation pipeline, blowing the ethanol in the ethanol circulation pipeline into the cleaning tank. The ethanol in the production system was rinsed by the injection water in the injection water tank. The mixture of ethanol and injection water during the rinsing process was discharged through the mandrel cover, thereby cleaning all the ethanol in the pipelines of the production system and the ethanol circulation pipeline. (3) After the production system was changed from producing true solution ampoules to producing suspension ampoules, the preparation tank in the production system needed to continuously circulate through the added suspension circulation pipeline according to the production requirements. The cleaning station added a cleaning return pipeline connected to the suspension circulation pipeline between the original cleaning pipeline and the cleaning tank, thereby enabling the cleaning of the suspension circulation pipeline as well, and realizing the comprehensive cleaning of the production system. Attached Figure Description

[0014] To more clearly illustrate the technical solutions in the embodiments of this utility model, the drawings used in the specification will be briefly introduced below. Obviously, the drawings described below are only some embodiments recorded in this utility model. For those skilled in the art, other drawings can be obtained based on these drawings.

[0015] Figure 1 This is a schematic diagram of the composition of the production and cleaning system for plastic ampoule solution in the background art of this utility model; Figure 2 This is a schematic diagram of the composition of the cleaning system in which the plastic ampoule suspension and the real solution are produced on the same production line in this embodiment of the present invention.

[0016] In the diagram: 1. Preparation tank; 11. Suspension circulation pipeline; 2. Cleaning tank; 21. Cleaning return pipeline; 3. Balance tank; 4. Filling needle; 5. Mandrel cover; 6. Injection water tank; 7. Ethanol circulation pipeline; 8. Nitrogen pipeline.

[0017] Furthermore, the valves on the pipeline in the diagram are labeled with letters a~h, as well as k, m, and n. Detailed Implementation

[0018] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, not all embodiments. For ease of explanation, the terms "vertical", "horizontal", "left", "right", "upper", "lower", "inner", "outer", "bottom", etc., used in this specification indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this application.

[0019] Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this utility model.

[0020] As attached Figure 2 As shown, a cleaning system for the co-production of plastic ampoule suspension and true solution is used to clean the tank equipment and pipelines in the production system.

[0021] The production system includes a preparation tank 1, a balance tank 3, and a filling needle 4. The preparation tank 1 stores the drug solution to be filled. When producing true solution ampoules, the preparation tank 1 stores the true solution drug solution; when producing suspension ampoules, the preparation tank 1 stores the suspension drug solution. According to production requirements, the suspension drug solution in the preparation tank 1 needs to circulate continuously. Therefore, a suspension circulation pipeline 11 is installed on the preparation tank 1. When producing suspension ampoules, valves a and e need to be opened to achieve the self-circulation of the suspension in the preparation tank 1.

[0022] It should be noted that other components in the pipeline, such as pressure gauges, flow meters, and circulation pumps, are not shown in the figure; furthermore, the positions of valves and connection points where pipelines intersect, as indicated in the attached figure, are not their actual locations on the pipeline. For example, valve a on the suspension circulation pipeline 11 is located at the end of the pipeline that delivers the cleaning medium, close to the bottom of the preparation tank 1, while valve e is located at the inlet end, close to the top of the preparation tank 1.

[0023] Both the balance tank 3 and the filling needle 4 are existing equipment. The balance tank 3 has the function of regulating and stabilizing pressure. Only the liquid medicine flowing out of the balance tank 3 can enter the filling needle 4 at a uniform flow rate, and then the filling needle 4 fills the liquid medicine into the plastic ampoule.

[0024] The cleaning system includes a cleaning tank 2, a spindle cover 5, an injection water tank 6, an ethanol circulation pipeline 7, and a nitrogen pipeline 8.

[0025] The cleaning tank 2 is used to store the cleaning medium of the cleaning production system. In this invention, the cleaning medium is purified water or ethanol. Specifically, when the production system produces true solution ampoules, the cleaning medium in the cleaning tank 2 is purified water; when the production system produces suspension ampoules, the cleaning medium in the cleaning tank 2 is ethanol.

[0026] A valve m is installed at the bottom of the cleaning tank 2. Valves m, c and b are installed on the pipeline from the cleaning medium in the cleaning tank 2 to the production system.

[0027] The injection tank 6 stores water for injection used in drug preparation, and the pipeline is kept clean after rinsing with the injection water. The pipeline from the injection tank 6 to the production system for supplying the cleaning medium is connected to the pipeline from the cleaning tank 2 to the production system, and valve k is installed on the pipeline from the injection tank 6 to the production system, located upstream of valve c. That is, valves k, c, and b are sequentially installed on the pipeline from the injection tank 6 to the production system for the injection water. When the cleaning tank 2 supplies the cleaning medium to the production system, valve m is open and valve k is closed; when the cleaning tank 2 finishes supplying the cleaning medium to the production system, valve m is closed and valve k is open.

[0028] The mandrel cover 5 is an existing stainless steel component, which is only installed below the filling needle 4 when the cleaning system is operating to receive the cleaning medium flowing out of the filling needle 4. When the production system is operating normally, the filling needle 4 only connects to the plastic ampoule bottle without the mandrel cover 5.

[0029] The bottom of the mandrel cover 5 is equipped with a pipeline for conveying cleaning medium. Valve g and valve d are installed on the pipeline for conveying cleaning medium. When both valve g and valve d are in the open state, the cleaning medium inside the mandrel cover 5 can be directly discharged.

[0030] The ethanol circulation line 7 is used to connect the mandrel cover 5 and the cleaning tank 2. Specifically, the end of the ethanol circulation line 7 near the cleaning tank 2 is located at the top of the cleaning tank 2, while the end of the ethanol circulation line 7 near the mandrel cover 5 is located on the cleaning medium conveying pipeline of the mandrel cover 5. The connection point between the ethanol circulation line 7 and the cleaning medium conveying pipeline of the mandrel cover 5 is located between valve g and valve d.

[0031] One end of the nitrogen pipeline 8 is connected to a nitrogen source, and the other end is connected to the ethanol circulation pipeline 7. Specifically, the connection point between the nitrogen pipeline 8 and the ethanol circulation pipeline 7 is located upstream of or at the same location as the connection point between the ethanol circulation pipeline 7 and the mandrel cover 5's cleaning medium delivery pipeline. The nitrogen pressure in the nitrogen pipeline 8 is adjustable, and nitrogen at a certain pressure can be used to purge the ethanol circulation pipeline 7. The use of nitrogen can prevent safety issues such as fire and explosion.

[0032] Because the production system adds a suspension circulation pipeline 11 during the production of suspension ampoules, a corresponding cleaning return pipeline 21 is added to the cleaning tank 2 to achieve comprehensive cleaning of the production system. That is, the cleaning medium flowing out of the cleaning tank 2 is diverted, so that part of the cleaning medium enters the suspension circulation pipeline 11 downstream of valve a and close to valve a, and is discharged and returned to the cleaning tank 2 downstream of the suspension circulation pipeline 11 near valve e and upstream of valve e, thereby achieving cleaning of the newly added suspension circulation pipeline 11.

[0033] The implementation principle of the above embodiments is as follows: The production system of this utility model has the following two working modes: I. Production of genuine solution ampoules: The preparation tank 1 stores the true solution. Valves a and b are opened, while valves c, e, and f are closed. The solution in the preparation tank 1 enters the balance tank 3 through valves a and b in sequence, and then the true solution ampoules are filled through the filling needle 4.

[0034] II. Production of suspension ampoules: The preparation tank 1 stores the suspension solution. Valves a, b, and e are open, while valves c and f are closed. The solution in the preparation tank 1 flows through valves a and e, achieving self-circulation of the suspension solution in the preparation tank 1. At the same time, the solution can enter the balance tank 3 through valves a and b in sequence, and then complete the filling of the suspension ampoules through the filling needle 4.

[0035] Corresponding to the different production modes of the production system, the cleaning system of this utility model has the following two working modes: 1. When it is necessary to clean the production system that has produced true solution ampoules: Purified water is stored in cleaning tank 2. Valves m, c, and b are open, while valve k below injection tank 6 is closed.

[0036] Furthermore, valve f on the cleaning return line 21, valve h on the ethanol circulation line 7, and valve n on the nitrogen line 8 are all closed.

[0037] The purified water in cleaning tank 2 enters balance tank 3 sequentially through valves m, c, and b, and then enters filling needle 4. The water discharged from filling needle 4 flows into mandrel cover 5. Valves g and d on the cleaning medium delivery pipe of mandrel cover 5 are both open, allowing the purified water that has rinsed the production system to be discharged directly.

[0038] 2. When it is necessary to clean the production system that has produced suspension ampoules: Ethanol is stored in cleaning tank 2. Valves m, c, and b are open, as are valve f on cleaning return line 21 and valve h on ethanol circulation line 7.

[0039] Furthermore, valve n on nitrogen pipeline 8 and valve k below injection water tank 6 are temporarily closed.

[0040] After passing through valve c, the ethanol in cleaning tank 2 enters balance tank 3 through valve b, and enters suspension circulation pipeline 11 downstream of valve a.

[0041] Ethanol entering the balance tank 3 flows through the pipeline into the filling needle 4, and ethanol discharged from the filling needle 4 enters the mandrel cover 5. Since the process of cleaning with ethanol requires circulating cleaning, and the ethanol used for cleaning needs to be collected and cannot be discharged, valve g on the cleaning medium delivery pipeline of the mandrel cover 5 is open while valve d is closed. The ethanol that has rinsed the production system returns to the cleaning tank 2 through valve h and along the ethanol circulation pipeline 7.

[0042] Ethanol entering the suspension circulation line 11 exits the suspension circulation line 11 upstream of valve e and enters the cleaning return line 21. After passing through valve f, it also returns to the cleaning tank 2.

[0043] Specifically, after the ethanol completes the rinsing of the production system, the circulation pump in the cleaning system stops, but some ethanol remains in the pipeline. At this time, valves m and g need to be closed, and then valve n needs to be opened. In this way, the nitrogen in the nitrogen pipeline 8 is used to purge the residual ethanol in the ethanol circulation pipeline 7 back to the cleaning tank 2. After the nitrogen purging is completed, valves n and h are closed, and the ethanol in the cleaning tank 2 is discharged for treatment. Then valves k and d are opened, and the clean injection water stored in the injection water tank 6 passes through valves k and c in sequence, then one path enters the balance tank 3 through valve b, and the other path enters the suspension circulation pipeline 11. After completing the rinsing of the cleaning return pipeline 21, it enters the cleaning tank 2 to continue rinsing the cleaning tank 2, and finally is discharged. The injection water entering the balance tank 3 rinses the filling needle 4 and then enters the mandrel cover 5. Valve d is in the open state, so the injection water rinsing solution in the mandrel cover 5 can be discharged. As a result, the residual ethanol in the production system and the cleaning return line 21 is rinsed clean with injected water, while the residual ethanol in the ethanol circulation line 7 is purged with nitrogen and returned to the cleaning tank 2.

[0044] Although preferred embodiments of the present invention have been described, those skilled in the art, upon learning the basic inventive concept, can make other changes and modifications to these embodiments. Therefore, the appended claims are intended to be interpreted as including both the preferred embodiments and all changes and modifications falling within the scope of the present invention. Clearly, those skilled in the art can make various alterations and modifications to the present invention without departing from its spirit and scope. Thus, if such modifications and modifications fall within the scope of the claims of the present invention and their equivalents, the present invention also intends to include such modifications and modifications.

Claims

1. A cleaning system for the co-production of plastic ampoule suspension and true solution, comprising a cleaning tank (2) and a mandrel cover (5), wherein the cleaning medium in the cleaning tank (2) enters the mandrel cover (5) through the pipeline of the production system, and the mandrel cover (5) can discharge the cleaning medium inside it, characterized in that, It also includes an injection water tank (6), an ethanol circulation pipeline (7) and a nitrogen pipeline (8). The injection water in the injection water tank (6) can enter the mandrel cover (5) through the pipeline of the production system. The ethanol circulation pipeline (7) connects the mandrel cover (5) and the cleaning tank (2). The nitrogen pipeline (8) connects the ethanol circulation pipeline (7). The nitrogen in the nitrogen pipeline (8) can purge the ethanol circulation pipeline (7).

2. The cleaning system for co-production of plastic ampoule suspension and true solution according to claim 1, characterized in that, The cleaning tank (2) is also provided with a cleaning return pipeline (21). The production system includes a preparation tank (1) and a suspension circulation pipeline (11) is provided on the preparation tank (1). The cleaning medium in the cleaning tank (2) can enter the suspension circulation pipeline (11) and return to the cleaning tank (2) through the cleaning return pipeline (21).

3. The cleaning system for co-production of plastic ampoule suspension and true solution according to claim 2, characterized in that, The suspension circulation pipeline (11) is equipped with valve a and valve e. Valve a is located at the end of the suspension circulation pipeline (11) that delivers the cleaning medium, and valve e is located at the inlet end of the suspension circulation pipeline (11). In the suspension circulation pipeline (11), the suspension in the preparation tank (1) passes through valve a and valve e in turn. The cleaning medium in the cleaning tank (2) enters the suspension circulation pipeline (11) from a position close to valve a and downstream of valve a. The connection position between the cleaning return pipeline (21) and the suspension circulation pipeline (11) is located close to valve e and upstream of valve e.

4. The cleaning system for co-production of plastic ampoule suspension and true solution according to claim 1, characterized in that, A valve g is provided between the spindle cover (5) and the ethanol circulation pipeline (7). The connection between the nitrogen pipeline (8) and the ethanol circulation pipeline (7) is located downstream of and close to the valve g. The valve g is closed when the nitrogen in the nitrogen pipeline (8) purges the ethanol circulation pipeline (7).

5. The cleaning system for co-production of plastic ampoule suspension and true solution according to claim 1, characterized in that, The pipeline from the injection tank (6) to the production system for conveying the cleaning medium is connected to the pipeline from the cleaning tank (2) to the production system for conveying the cleaning medium. A valve m is installed on the pipeline from the cleaning tank (2) to the production system for conveying the cleaning medium, and a valve k is installed on the pipeline from the injection tank (6) to the production system for conveying the cleaning medium.

6. The cleaning system for co-production of plastic ampoule suspension and true solution according to claim 5, characterized in that, The valve m is opened when the cleaning tank (2) delivers the cleaning medium to the production system and closed when the injection water tank (6) delivers the cleaning medium to the production system. The valve k is closed when the cleaning tank (2) delivers the cleaning medium to the production system and opened after the cleaning tank (2) has finished delivering the cleaning medium to the production system.

7. The cleaning system for co-production of plastic ampoule suspension and true solution according to claim 5, characterized in that, The injection water tank (6) and the cleaning tank (2) are equipped with valves c on the pipelines that deliver the cleaning medium to the production system. The valves c are closed during the operation of the production system.

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