Convenient energy-saving low-temperature crystallization device

Abstract

The utility model relates to low temperature crystallization technical field, and disclose a kind of low temperature crystallization device of convenient energy saving, including base, the top end of base is fixedly connected with base at left side place close, the middle part of base is fixedly sleeved with double-layer heat preservation crystallization jar, the top end of double-layer heat preservation crystallization jar is fixedly connected with protective shell, the top end middle part of base is fixedly connected with support seat, the top end right side of base is fixedly connected with mixing tank, the rear side of double-layer heat preservation crystallization jar is equipped with refrigerant outlet, and then backflow to refrigeration compressor through refrigerant outlet, pass through the flow of multiple-point temperature sensor data adjustment, the accurate cooling crystallization of mixed solution in double-layer heat preservation crystallization jar, open electric valve two, high temperature refrigerant is transferred to the heat preservation layer of mixing tank through high temperature refrigerant pipe, heat exchange is carried out to the medical intermediate mixed solution to be preheated, make medical intermediate mixed solution temperature rise, simultaneously make high temperature refrigerant cool, it is favorable to improve energy utilization, guarantee the development demand of energy saving and cost reduction of pharmaceutical industry.

Description

Technical Field

[0001] This utility model relates to the field of low-temperature crystallization technology, and more specifically to a convenient and energy-saving low-temperature crystallization device. Background Technology

[0002] Pharmaceutical intermediates are key intermediate products used in the synthesis of drugs. They are the core bridge connecting chemical raw materials and final drugs (active pharmaceutical ingredients or preparations). They do not have direct medicinal value, but they are indispensable "semi-finished products" in drug production. Low-temperature crystallization is the core process for achieving high-purity purification in the production of pharmaceutical intermediates. It can precipitate the target intermediate from the mixture in a low-temperature environment, thereby separating it into high-purity products.

[0003] According to research, the working steps of a low-temperature crystallization device for pharmaceutical intermediate production revolve around the core logic of "dissolution-cooling crystallization-separation-purification". Strict control of parameters such as temperature, stirring, and time is required to ensure the purity, yield, and crystal morphology of the intermediates (to avoid affecting the compatibility of subsequent processes). Basic preparations must be completed before formal operation to avoid batch failures due to material compatibility or equipment malfunction. The liquid to be crystallized is converted into a "high-temperature clear solution" to provide a uniform system for subsequent cooling crystallization, while ensuring that impurities are fully dissolved (facilitating subsequent separation). Cooling and crystallization create supersaturation and guide crystal growth. After complete crystallization (confirmed by sampling that there are no obvious unprecipitated solids in the solution), the crystals and mother liquor (containing unprecipitated target substances and impurities) must be separated at low temperature to prevent the crystals from redissolving.

[0004] The shortcomings of existing technologies: Traditional low-temperature crystallization devices for pharmaceutical intermediate production rely on continuous cooling by compressors to maintain a low-temperature environment. During the cooling process, heat is directly discharged to the outside, resulting in low energy utilization and high energy consumption per unit. This does not meet the development needs of energy conservation and consumption reduction in the pharmaceutical industry. The mixing of the liquid is mostly uniform in one direction. Under low-temperature conditions, the temperature distribution of the liquid is uneven, which can easily lead to local overcooling and crystal agglomeration. This not only prolongs the crystallization time but also introduces impurities into the crystals, increasing the cost of subsequent drying and purification.

[0005] Therefore, there is a need to provide a convenient and energy-saving low-temperature crystallization device to solve the problems mentioned above. Utility Model Content

[0006] In order to overcome the above-mentioned defects of the prior art, the present invention provides a convenient and energy-saving low-temperature crystallization device to solve the problems existing in the background art.

[0007] This utility model provides the following technical solution: a convenient and energy-saving low-temperature crystallization device, including a base, a base fixedly connected to the top of the base near the left side, a double-layer insulated crystallization tank fixedly sleeved in the middle of the base, a protective shell fixedly connected to the top of the double-layer insulated crystallization tank, a support base fixedly connected to the middle of the top of the base, a mixing tank fixedly connected to the right side of the top of the base, a refrigerant outlet opened on the rear side of the double-layer insulated crystallization tank, a filter plate fixedly connected to the inside of the double-layer insulated crystallization tank near the bottom, a crystal outlet tube fixedly connected to the middle of the bottom of the double-layer insulated crystallization tank, and a solenoid valve fixedly connected to the middle of the crystal outlet tube.

[0008] Convenient and energy-saving low-temperature crystallization devices also include:

[0009] An energy-saving component is installed between the double-layer insulated crystallizer and the mixing tank to recover and reuse the heat generated during low-temperature crystallization.

[0010] A bidirectional mixing component is disposed inside the protective shell and the double-layer insulated crystallizer, and is used to bidirectionally stir the mixture in the double-layer insulated crystallizer.

[0011] Preferably, the energy-saving component includes a refrigeration compressor, the bottom end of which is fixedly connected to the top end of the support base, a main refrigerant pipe fixedly connected to the top end of the refrigeration compressor, the left end of the main refrigerant pipe fixedly connected to a double-layer insulated crystallizing tank, the refrigerant outlet fixedly connected to the refrigeration compressor via a pipe, a high-temperature refrigerant pipe fixedly connected to the right end of the refrigeration compressor, and the right end of the high-temperature refrigerant pipe fixedly connected to a mixing tank.

[0012] Preferably, an electric valve one is fixedly connected near the left end of the main refrigerant pipe, and an electric valve two is fixedly connected in the middle of the high-temperature refrigerant pipe.

[0013] Preferably, an inlet pipe is fixedly connected to the top center of the mixing tank, and an outlet pipe is fixedly connected to the right side of the mixing tank near the bottom.

[0014] Preferably, the bidirectional hybrid component includes:

[0015] A U-shaped frame is fixedly connected at its bottom end to the top of a double-layer insulated crystallization tank. Both ends of the left side of the U-shaped frame are fixedly connected to sleeve blocks. A stirring shaft is movably sleeved in the middle of the sleeve block near the top. A stirring blade is fixedly sleeved through the outer wall of the stirring shaft and through the double-layer insulated crystallization tank. A second stirring shaft is movably sleeved in the middle of the sleeve block near the bottom end. A stirring blade is fixedly sleeved through the outer wall of the second stirring shaft and through the double-layer insulated crystallization tank. The outer wall of the first stirring shaft and the inner wall of the second stirring shaft are movably sleeved together. A limit block is fixedly connected through the sleeve block at the top end of the first stirring shaft.

[0016] A driving mechanism is provided on the outer wall of the second stirring shaft and the first stirring shaft, and is used to drive the second stirring shaft and the first stirring shaft to rotate in opposite directions.

[0017] Preferably, a secondary bevel gear is fixedly sleeved on the outer wall of the first stirring shaft located at the bottom of the sleeve block, and a secondary bevel gear is fixedly sleeved on the outer wall of the second stirring shaft located at the top of the sleeve block. A main bevel gear meshes between the outer walls of the secondary bevel gear and the secondary bevel gear. A drive motor is fixedly connected to the right side of the U-shaped frame, and the transmission end of the drive motor passes through the U-shaped frame and is fixedly sleeved with the main bevel gear.

[0018] The technical effects and advantages of this utility model are as follows:

[0019] 1. This utility model, by incorporating energy-saving components, allows for precise cooling and crystallization of the mixture in a double-layered insulated crystallizing tank. The refrigeration compressor and electric valve one are activated, transferring refrigerant through the main refrigerant pipe to the internal insulation layer of the double-layered insulated crystallizing tank. The refrigerant then flows back to the refrigeration compressor through the refrigerant outlet. The flow rate is adjusted using data from multiple temperature sensors, ensuring accurate cooling and crystallization of the mixture in the double-layered insulated crystallizing tank. Electric valve two is then activated, allowing high-temperature refrigerant to be transferred through the high-temperature refrigerant pipe to the insulation layer of the mixing tank. This facilitates heat exchange with the preheated pharmaceutical intermediate mixture, raising its temperature while simultaneously cooling the high-temperature refrigerant. This improves energy efficiency and meets the energy-saving and consumption-reducing development needs of the pharmaceutical industry.

[0020] 2. This utility model, by incorporating a bidirectional mixing component, allows for the uniform cooling and crystallization of the pharmaceutical intermediate mixture within a double-layered insulated crystallizer. Under the protection of the protective shell and the support of the U-shaped frame, the drive motor is activated, causing the main bevel gear to rotate. This, in turn, causes the secondary bevel gears one and two to rotate in opposite directions. With the rotational connection of the two sleeve blocks and the limiting block, the stirring shaft one rotates in the opposite direction within the stirring shaft two. This facilitates the opposite rotation of the stirring blades two and one within the double-layered insulated crystallizer, ensuring uniform stirring of the pharmaceutical intermediate mixture, resulting in even cooling, reduced crystallization time, and ultimately, improved crystallization efficiency. Attached Figure Description

[0021] Figure 1 This is a schematic diagram of the overall structure of this utility model.

[0022] Figure 2 This is a cross-sectional view of the overall structure of this utility model.

[0023] Figure 3 This is a cross-sectional view of the bidirectional hybrid component of this utility model.

[0024] Figure 4 This is an enlarged schematic diagram of the structure at point A of this utility model.

[0025] Figure 5 This is a schematic diagram of the structure of the energy-saving component of this utility model.

[0026] The attached diagram is labeled as follows: 1. Double-layer insulated crystallizer; 2. Protective shell; 3. Base; 4. Base; 5. Support base; 6. Energy-saving component; 601. Main refrigerant pipe; 602. Electric valve one; 603. Refrigeration compressor; 604. Electric valve two; 605. High-temperature refrigerant pipe; 7. Mixing tank; 701. Liquid inlet pipe; 8. Liquid outlet pipe; 9. Two-way mixing component; 901. Stirring blade two; 902. Stirring shaft two; 903. Stirring blade one; 904. Stirring shaft one; 905. Limiting block; 906. Sleeve block; 907. Secondary bevel gear one; 908. Secondary bevel gear two; 909. Main bevel gear; 910. U-shaped frame; 911. Drive motor; 10. Filter plate; 11. Crystal outlet pipe; 12. Solenoid valve. Detailed Implementation

[0027] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of the present utility model.

[0028] like Figure 1-5 As shown, this utility model has the following two specific embodiments.

[0029] Example 1

[0030] This utility model is a convenient and energy-saving low-temperature crystallization device, including a base 4, a base 3 fixedly connected to the top of the base 4 near the left side, a double-layer insulated crystallization tank 1 fixedly sleeved in the middle of the base 3, a protective shell 2 fixedly connected to the top of the double-layer insulated crystallization tank 1, a support base 5 fixedly connected to the top middle of the base 4, a mixing tank 7 fixedly connected to the top right of the base 4, a refrigerant outlet opened on the rear side of the double-layer insulated crystallization tank 1, a filter plate 10 fixedly connected to the inside of the double-layer insulated crystallization tank 1 near the bottom, a crystal outlet pipe 11 fixedly connected to the bottom middle of the double-layer insulated crystallization tank 1, and a solenoid valve 12 fixedly connected to the middle of the crystal outlet pipe 11.

[0031] Convenient and energy-saving low-temperature crystallization devices also include:

[0032] Energy-saving component 6 is installed between the double-layer insulated crystallizer 1 and the mixing tank 7 to recover and reuse the heat generated during low-temperature crystallization.

[0033] The bidirectional mixing component 9 is disposed inside the protective shell 2 and the double-layer insulated crystallizer 1, and is used to bidirectionally stir the mixture in the double-layer insulated crystallizer 1.

[0034] The energy-saving component 6 includes a refrigeration compressor 603. The bottom end of the refrigeration compressor 603 is fixedly connected to the top end of the support base 5. The top end of the refrigeration compressor 603 is fixedly connected to the main refrigerant pipe 601. The left end of the main refrigerant pipe 601 is fixedly connected to the double-layer insulated crystallizing tank 1. The refrigerant outlet is fixedly connected to the refrigeration compressor 603 through a pipe. The right end of the refrigeration compressor 603 is fixedly connected to a high-temperature refrigerant pipe 605. The right end of the high-temperature refrigerant pipe 605 is fixedly connected to the mixing tank 7.

[0035] An electric valve 602 is fixedly connected to the left end of the main refrigerant pipe 601, and an electric valve 604 is fixedly connected to the middle of the high-temperature refrigerant pipe 605.

[0036] An inlet pipe 701 is fixedly connected to the top center of the mixing tank 7, and an outlet pipe 8 is fixedly connected to the right side of the mixing tank 7 near the bottom.

[0037] In this embodiment, as Figure 1-2 and Figure 5 As shown, the refrigeration compressor 603 and the first electric valve 602 are turned on, and the refrigerant is transferred through the main refrigerant pipe 601 to the internal insulation layer of the double-layer insulated crystallizer 1. Then, it flows back to the refrigeration compressor 603 through the refrigerant outlet. The flow rate is adjusted by the data of the multi-point temperature sensor to precisely cool and crystallize the mixture in the double-layer insulated crystallizer 1. The second electric valve 604 is turned on, and the high-temperature refrigerant is transferred through the high-temperature refrigerant pipe 605 to the insulation layer of the mixing tank 7 to exchange heat with the pharmaceutical intermediate mixture to be preheated.

[0038] Example 2

[0039] The difference from Embodiment 1 is that this embodiment discloses a bidirectional hybrid component 9 comprising:

[0040] U-shaped frame 910, the bottom end of U-shaped frame 910 is fixedly connected to the top end of double-layer heat-insulated crystallization tank 1. Both ends of the left side of U-shaped frame 910 are fixedly connected to sleeve blocks 906. The middle part of sleeve block 906 near the top end is movably sleeved with stirring shaft 904. The outer wall of stirring shaft 904 penetrates the double-layer heat-insulated crystallization tank 1 and is fixedly sleeved with stirring blade 903. The middle part of sleeve block 906 near the bottom end is movably sleeved with stirring shaft 902. The outer wall of stirring shaft 902 penetrates the double-layer heat-insulated crystallization tank 1 and is fixedly sleeved with stirring blade 901. The outer wall of stirring shaft 904 and the inner wall of stirring shaft 902 are movably sleeved. The top end of stirring shaft 904 penetrates sleeve block 906 and is fixedly connected with limit block 905.

[0041] A drive mechanism is installed on the outer wall of the second stirring shaft 902 and the first stirring shaft 904, and is used to drive the second stirring shaft 902 and the first stirring shaft 904 to rotate in opposite directions.

[0042] A secondary bevel gear 907 is fixedly sleeved on the outer wall of the stirring shaft 904 located at the bottom of the sleeve block 906. A secondary bevel gear 908 is fixedly sleeved on the outer wall of the stirring shaft 902 located at the top of the sleeve block 906. A main bevel gear 909 meshes between the outer walls of the secondary bevel gear 907 and the secondary bevel gear 908. A drive motor 911 is fixedly connected to the right side of the U-shaped frame 910. The transmission end of the drive motor 911 passes through the U-shaped frame 910 and is fixedly sleeved with the main bevel gear 909.

[0043] In this embodiment, as Figure 1-4 As shown, when the drive motor 911 is turned on, the main bevel gear 909 rotates, which in turn drives the secondary bevel gear 907 and the secondary bevel gear 908 to rotate in the opposite direction. Under the rotational connection of the two sleeve blocks 906 and the limitation of the limiting block 905, the stirring shaft 904 rotates in the opposite direction within the stirring shaft 902, which in turn facilitates the stirring blades 901 and 903 to rotate in the opposite direction within the double-layer insulated crystallizing tank 1.

[0044] The working principle of this invention is as follows: When cooling and crystallizing the mixture in the double-layer insulated crystallizer 1, the refrigeration compressor 603 and the first electric valve 602 are turned on, and the refrigerant is transferred through the main refrigerant pipe 601 to the internal insulation layer of the double-layer insulated crystallizer 1, and then flows back to the refrigeration compressor 603 through the refrigerant outlet. The flow rate is adjusted by data from multiple temperature sensors to precisely cool and crystallize the mixture in the double-layer insulated crystallizer 1. The second electric valve 604 is turned on, and the high-temperature refrigerant is transferred through the high-temperature refrigerant pipe 605 to the insulation layer of the mixing tank 7 to exchange heat with the preheated pharmaceutical intermediate mixture, thereby raising the temperature of the pharmaceutical intermediate mixture and simultaneously cooling and crystallizing the high-temperature refrigerant. During the cooling process, while the pharmaceutical intermediate mixture in the double-layer insulated crystallization tank 1 is being uniformly cooled and crystallized, the drive motor 911 is activated under the protection of the protective shell 2 and the support of the U-shaped frame 910. This drives the main bevel gear 909 to rotate, which in turn drives the secondary bevel gear 1 907 and secondary bevel gear 2 908 to rotate in the opposite direction. Under the rotational connection of the two sleeve blocks 906 and the limiting block 905, the stirring shaft 1 904 rotates in the opposite direction within the stirring shaft 2 902. This, in turn, drives the stirring fan blade 2 901 and stirring fan blade 1 903 to rotate in the opposite direction within the double-layer insulated crystallization tank 1, uniformly stirring the pharmaceutical intermediate mixture in the double-layer insulated crystallization tank 1 and ensuring uniform cooling.

[0045] Finally, the following points should be noted: First, in the description of this application, it should be noted that, unless otherwise specified and limited, the terms "installation", "connection", and "linkage" should be interpreted broadly, and can be mechanical or electrical connections, or internal connections between two components, or direct connections. "Up", "down", "left", "right", etc. are only used to indicate relative positional relationships. When the absolute position of the described object changes, the relative positional relationship may change.

[0046] Secondly: The accompanying drawings of the embodiments disclosed in this utility model only involve the structures involved in the embodiments disclosed in this utility model. Other structures can refer to the general design. In the absence of conflict, the same embodiment and different embodiments of this utility model can be combined with each other.

[0047] Finally: The above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A convenient and energy-saving low-temperature crystallization device, comprising a base (4), characterized in that: A base (3) is fixedly connected to the top of the base (4) near the left side. A double-layer heat-insulating crystallizer (1) is fixedly sleeved in the middle of the base (3). A protective shell (2) is fixedly connected to the top of the double-layer heat-insulating crystallizer (1). A support base (5) is fixedly connected to the middle of the top of the base (4). A mixing tank (7) is fixedly connected to the right side of the top of the base (4). A refrigerant outlet is opened on the rear side of the double-layer heat-insulating crystallizer (1). A filter plate (10) is fixedly connected to the inside of the double-layer heat-insulating crystallizer (1) near the bottom. A crystal outlet pipe (11) is fixedly connected to the middle of the bottom of the double-layer heat-insulating crystallizer (1). A solenoid valve (12) is fixedly connected to the middle of the crystal outlet pipe (11). Convenient and energy-saving low-temperature crystallization devices also include: Energy-saving component (6), which is set between the double-layer heat-insulated crystallizer (1) and the mixing tank (7), is used to recover and reuse the heat generated during low-temperature crystallization; A bidirectional mixing component (9) is disposed inside the protective shell (2) and the double-layer insulated crystallizer (1) for bidirectional stirring of the mixture in the double-layer insulated crystallizer (1).

2. The convenient and energy-saving low-temperature crystallization device according to claim 1, characterized in that: The energy-saving component (6) includes a refrigeration compressor (603), the bottom end of which is fixedly connected to the top end of the support base (5), the top end of which is fixedly connected to a main refrigerant pipe (601), the left end of which is fixedly connected to a double-layer insulated crystallizing tank (1), the refrigerant outlet being fixedly connected to the refrigeration compressor (603) via a pipe, the right end of which is fixedly connected to a high-temperature refrigerant pipe (605), and the right end of which is fixedly connected to a mixing tank (7).

3. The convenient and energy-saving low-temperature crystallization device according to claim 2, characterized in that: An electric valve (602) is fixedly connected to the left end of the main refrigerant pipe (601), and an electric valve (604) is fixedly connected to the middle of the high-temperature refrigerant pipe (605).

4. The convenient and energy-saving low-temperature crystallization device according to claim 1, characterized in that: The mixing tank (7) is fixedly connected to the top center of the liquid inlet pipe (701), and the mixing tank (7) is fixedly connected to the right side near the bottom end of the liquid outlet pipe (8).

5. The convenient and energy-saving low-temperature crystallization device according to claim 1, characterized in that: The bidirectional hybrid component (9) includes: A U-shaped frame (910) is fixedly connected at its bottom end to the top end of a double-layer insulated crystallizing tank (1). Both ends of the left side of the U-shaped frame (910) are fixedly connected to a sleeve block (906). A stirring shaft (904) is movably sleeved in the middle of the sleeve block (906) near the top end. A stirring fan blade (903) is fixedly sleeved through the double-layer insulated crystallizing tank (1) on the outer wall of the stirring shaft (904). A stirring shaft (902) is movably sleeved in the middle of the sleeve block (906) near the bottom end. A stirring fan blade (901) is fixedly sleeved through the double-layer insulated crystallizing tank (1) on the outer wall of the stirring shaft (904). The outer wall of the stirring shaft (904) is movably sleeved with the inner wall of the stirring shaft (902). A limit block (905) is fixedly connected through the sleeve block (906) at the top end of the stirring shaft (904). A driving mechanism is provided on the outer wall of the second stirring shaft (902) and the first stirring shaft (904) for driving the second stirring shaft (902) and the first stirring shaft (904) to rotate in opposite directions.

6. The convenient and energy-saving low-temperature crystallization device according to claim 5, characterized in that: A secondary bevel gear 1 (907) is fixedly sleeved on the outer wall of the first stirring shaft (904) located at the bottom of the sleeve block (906). A secondary bevel gear 2 (908) is fixedly sleeved on the outer wall of the second stirring shaft (902) located at the top of the sleeve block (906). A main bevel gear (909) meshes between the outer walls of the secondary bevel gear 1 (907) and the secondary bevel gear 2 (908). A drive motor (911) is fixedly connected to the right side of the U-shaped frame (910). The transmission end of the drive motor (911) passes through the U-shaped frame (910) and is fixedly sleeved with the main bevel gear (909).

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