A continuous elution device for heparin sodium preparation

Abstract

The utility model discloses a continuous elution device for heparin sodium preparation, including continuous elution column and the silica gel adsorbent of setting in the inside of continuous elution column, the both ends of silica gel adsorbent are provided with first filter plate, second filter plate respectively, the lower end surface of second filter plate is provided with press lifting assembly, and the press lifting assembly sits in the inside bottom end of continuous elution column. The utility model discloses through the setting of press lifting assembly makes silica gel adsorbent through the mode of pressing and elongation and shortening, and the silica gel adsorbent of shortening can be set in the inside of continuous elution column and carries out the washing of mixed solution, and the silica gel adsorbent of elongation makes its one end stretch out the continuous elution column, so that the silica gel adsorbent can be directly pulled out from the continuous elution column, thereby avoid the problem that the silica gel adsorbent setting in the inside of continuous elution column and the silica gel adsorbent are not easy to pour out due to the greater adsorption strength of the inside wall surface of continuous elution column.

Description

Technical Field

[0001] This invention belongs to the field of heparin sodium preparation technology, and particularly relates to a continuous elution device for heparin sodium preparation. Background Technology

[0002] A continuous elution apparatus for heparin sodium preparation is a device used to produce heparin sodium, primarily for extracting heparin from animal tissues (such as pig intestines or bovine lungs) and purifying it through a continuous elution process. This equipment can efficiently and stably extract and purify heparin sodium, making it suitable for industrial production. After heparin is extracted from animal tissues, it is first extracted with an acidic solution. Heparin usually coexists with other impurities and needs to be separated from the tissue through a series of chemical reactions. Then, continuous elution is used to continuously separate heparin from the extract through liquid flow. The eluent typically contains salt solutions, buffer solutions, or other chemical reagents of varying concentrations. By controlling the flow rate and liquid ratio, heparin is separated from other impurities, achieving purification. Finally, it is concentrated to obtain heparin sodium.

[0003] Currently, commonly used continuous elution devices for heparin sodium preparation include an elution column and an adsorbent (usually silica gel) placed inside the elution column. The adsorbent filters and purifies the mixture containing heparin sodium. As the adsorbent is used for a long time, it needs to be replaced. The common method for replacing the adsorbent is to pour out the adsorbent from the elution column and then put the new adsorbent into the elution column. However, as the adsorbent is used, water stains will adhere to the surface of the adsorbent. The water stains on the surface of the adsorbent will increase the adsorption force between the adsorbent and the inner wall of the elution column. If the adsorption force between the adsorbent and the inner wall of the elution column is large, the adsorbent inside the elution column will not be easy to pour out.

[0004] Therefore, we propose a continuous elution apparatus for the preparation of heparin sodium. Summary of the Invention

[0005] To address the aforementioned problems, the purpose of this invention is to provide a continuous elution apparatus for the preparation of heparin sodium.

[0006] To achieve the above objectives, this utility model proposes a continuous elution device for preparing heparin sodium, comprising a continuous elution column and a silica gel adsorbent disposed inside the continuous elution column. A first filter plate and a second filter plate are respectively disposed at both ends of the silica gel adsorbent. A pressing and lifting assembly is disposed on the lower end face of the second filter plate. The pressing and lifting assembly is seated at the bottom end of the inner side of the continuous elution column.

[0007] Preferably, the pressing and lifting assembly includes a support ring disposed below the second filter plate and a connecting plate disposed on the lower end face of the second filter plate. The upper end face of the support ring is provided with a receiving groove, and the connecting plate is inserted into the receiving groove on the upper end face of the support ring.

[0008] Preferably, the support ring has a guide groove, which is V-shaped. A limit groove is provided at the upper end of the bend of the guide groove. A slider is provided on the connecting plate, and the slider is slidably connected in the guide groove.

[0009] Preferably, a reset spring is provided between the second filter plate and the support ring, and the reset spring is located inside the receiving groove.

[0010] Preferably, a rotating ring is provided at the bottom inner side of the receiving groove and the lower end face of the second filter plate. A limiting ring is provided on the rotating ring. The two limiting rings are rotatably connected to the bottom inner side of the receiving groove and the lower end face of the second filter plate, respectively. The cross-section of the limiting ring is an isosceles trapezoid.

[0011] Preferably, the outlet tube of the continuous elution column is provided with two control knobs, and the positions of the two control knobs correspond to each other.

[0012] Preferably, multiple guide grooves and connecting plates are provided, and the positions of the multiple connecting plates correspond to the positions of the multiple guide grooves.

[0013] The continuous elution apparatus for preparing heparin sodium proposed in this invention can bring the following beneficial effects: The press-and-lift assembly allows the silica gel adsorbent to stretch and shrink by pressing. The shortened silica gel adsorbent can be placed inside the continuous elution column to elute the mixture, while the stretched silica gel adsorbent extends one end out of the continuous elution column, allowing it to be pulled out directly from the column. This avoids the problem of the silica gel adsorbent being difficult to pour out due to the strong adhesion between the adsorbent placed inside the continuous elution column and the inner wall. Attached Figure Description

[0014] The accompanying drawings, which are provided to further illustrate the present invention and constitute a part of the present invention, illustrate exemplary embodiments of the present invention and are used to explain the present invention, but do not constitute an undue limitation of the present invention.

[0015] In the attached diagram: Figure 1 This is a schematic diagram of the overall structure of this utility model.

[0016] Figure 2 This is a cross-sectional view of the present invention.

[0017] Figure 3 This is a split diagram of the silica gel adsorbent of this utility model.

[0018] Figure 4 This is an exploded view of the press-and-lift assembly of this utility model.

[0019] Figure 5 This is a cross-sectional view of the press-and-lift assembly of this utility model.

[0020] Figure 6 For the present utility model Figure 5 Enlarged view of point A in the middle.

[0021] In the picture: 1. Continuous elution column; 2. Silica gel adsorbent; 3. First filter plate; 4. Second filter plate; 5. Pressing and lifting assembly; 51. Support ring; 52. Connecting plate; 53. Receiving groove; 54. Guide groove; 55. Limiting groove; 56. Sliding block; 57. Return spring; 6. Rotary ring; 7. Limiting ring; 9. Control knob. Detailed Implementation

[0022] To more clearly illustrate the overall concept of this utility model, a detailed description will be provided below with reference to the accompanying drawings.

[0023] In the description of this utility model, it should be understood that the terms "center", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "axial", "radial", "circumferential", etc., indicating the orientation or positional relationship are based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing this utility model and simplifying the description, and are not intended to indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model.

[0024] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this utility model, "a plurality of" means two or more, unless otherwise explicitly specified.

[0025] In this utility model, unless otherwise explicitly specified and limited, the terms "installation," "connection," "linking," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection, an electrical connection, or a communication connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0026] In this invention, unless otherwise expressly specified and limited, the first feature "on" or "below" the second feature may be in direct contact with the first and second features, or indirect contact through an intermediate medium. In the description of this specification, references to terms such as "a solution," "some solutions," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that solution or example is included in at least one solution or example of this invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same solution or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more solutions or examples.

[0027] like Figures 1-6 As shown in the figure, an embodiment of the present invention provides a continuous elution device for preparing heparin sodium, including a continuous elution column 1 and a silica gel adsorbent 2 disposed inside the continuous elution column 1. A first filter plate 3 and a second filter plate 4 are respectively disposed at both ends of the silica gel adsorbent 2. A pressing and lifting assembly 5 is disposed on the lower end surface of the second filter plate 4. The pressing and lifting assembly 5 is seated at the bottom end of the inner side of the continuous elution column 1.

[0028] like Figure 4 As shown, the pressing and lifting assembly 5 includes a support ring 51 disposed below the second filter plate 4 and a connecting plate 52 disposed on the lower end face of the second filter plate 4. The upper end face of the support ring 51 has a receiving groove 53, and the connecting plate 52 is inserted into the receiving groove 53 on the upper end face of the support ring 51. The support ring 51 has a guide groove 54, which is V-shaped. A limiting groove 55 is formed at the upper end of the bend of the guide groove 54. A slider 56 is disposed on the connecting plate 52, and the slider 56 is slidably connected within the guide groove 54. A return spring 57 is disposed between the second filter plate 4 and the support ring 51, and the return spring 57 is located inside the receiving groove 53.

[0029] When replacing the silica gel adsorbent 2, press the first filter plate 3. The first filter plate 3, through the silica gel adsorbent 2, drives the connecting plate 52 on the second filter plate 4 to push out from the limiting groove 55 inside the guide groove 54 via the slider 56. Then rotate the first filter plate 3. The first filter plate 3, through the silica gel adsorbent 2, drives the slider 56 connected to the second filter plate 4 to disengage from the limiting groove 55 inside the guide groove 54. Then stop pressing the first filter plate 3. At this time, the return spring 57 pushes the second filter plate 4 and the silica gel adsorbent 2 on the second filter plate 4 upward along the guide groove 54 through the connecting plate 52. When the slider 56 on the connecting plate 52 moves to the beginning of the stroke of the guide groove 54, one end of the silica gel adsorbent 2 and the first filter plate 3 on it are pushed out of the continuous elution column 1. Then remove the silica gel adsorbent 2 from the continuous elution column 1. Then, set the new continuous elution column 1 inside the continuous elution column 1 in the reverse order of the above steps.

[0030] By pressing the lifting assembly 5, the silica gel adsorbent 2 can be stretched and shortened by pressing. The shortened silica gel adsorbent 2 can be placed inside the continuous elution column 1 to elute the mixture. The stretched silica gel adsorbent 2 extends one end out of the continuous elution column 1, so that the silica gel adsorbent 2 can be directly pulled out from the continuous elution column 1. This avoids the problem that the silica gel adsorbent 2 placed inside the continuous elution column 1 has a strong adsorption force with the inner wall of the continuous elution column 1, which makes it difficult to pour out the silica gel adsorbent 2.

[0031] like Figure 6 As shown, a rotating ring 6 is provided on the bottom inner side of the receiving groove 53 and the lower end face of the second filter plate 4. A limiting ring 7 is provided on the rotating ring 6. The two limiting rings 7 are rotatably connected to the bottom inner side of the receiving groove 53 and the lower end face of the second filter plate 4, respectively. The cross-section of the limiting ring 7 is an isosceles trapezoid.

[0032] It should be noted that the two ends of the return spring 57 are connected to the two rotating rings 6 respectively.

[0033] The setting of the rotating ring 6 and the limiting ring 7 allows the reset spring 57 to rotate between the bottom end of the inner side of the receiving groove 53 and the second filter plate 4, which can reduce the friction between the reset spring 57 and the bottom end of the inner side of the receiving groove 53 and the lower end face of the second filter plate 4 due to rotation.

[0034] The continuous elution column 1 has two control knobs 9 on its outlet pipe, and the positions of the two control knobs 9 are corresponding to each other. The amount of liquid discharged from the continuous elution column 1 can be adjusted by setting the control knobs 9.

[0035] Multiple guide grooves 54 and connecting plates 52 are provided, with the positions of the multiple connecting plates 52 corresponding to the positions of the multiple guide grooves 54. The arrangement of multiple connecting plates 52 and guide grooves 54 ensures high lifting stability of the pressing and lifting assembly 5.

[0036] Working principle: When the silica gel adsorbent 2 needs to be replaced, press the first filter plate 3. The first filter plate 3, through the silica gel adsorbent 2, drives the connecting plate 52 on the second filter plate 4 to push out from the limiting groove 55 inside the guide groove 54 via the slider 56. Then rotate the first filter plate 3. The first filter plate 3, through the silica gel adsorbent 2, drives the slider 56 connected to the second filter plate 4 to be misaligned with the limiting groove 55 inside the guide groove 54. Then stop pressing the first filter plate 3. At this time, the return spring 57 pushes the second filter plate 4 and the silica gel adsorbent 2 on the second filter plate 4 upward along the guide groove 54 through the connecting plate 52. When the slider 56 on the connecting plate 52 moves to the beginning of the stroke of the guide groove 54, one end of the silica gel adsorbent 2 and the first filter plate 3 on it are pushed out of the continuous elution column 1. Then remove the silica gel adsorbent 2 from the continuous elution column 1. Then, set the new continuous elution column 1 inside the continuous elution column 1 in the reverse order of the above steps.

[0037] The various embodiments in this specification are described in a progressive manner. Similar or identical parts between embodiments can be referred to interchangeably. Each embodiment focuses on describing the differences from other embodiments. In particular, the system embodiments are basically similar to the method embodiments, so the description is relatively simple; relevant parts can be referred to the descriptions in the method embodiments.

[0038] The above description is merely an embodiment of this utility model and is not intended to limit the scope of this utility model. Various modifications and variations can be made to this utility model by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principle of this utility model should be included within the scope of the claims of this utility model.

Claims

1. A continuous elution apparatus for preparing heparin sodium, comprising a continuous elution column (1) and a silica gel adsorbent (2) disposed inside the continuous elution column (1), wherein a first filter plate (3) and a second filter plate (4) are respectively disposed at both ends of the silica gel adsorbent (2), characterized in that, The lower end face of the second filter plate (4) is provided with a pressing and lifting assembly (5), which is located at the bottom of the inner side of the continuous elution column (1).

2. The continuous elution apparatus for preparing heparin sodium according to claim 1, characterized in that, The pressing and lifting assembly (5) includes a support ring (51) disposed below the second filter plate (4) and a connecting plate (52) disposed on the lower end face of the second filter plate (4). The upper end face of the support ring (51) is provided with a receiving groove (53), and the connecting plate (52) is inserted into the receiving groove (53) on the upper end face of the support ring (51).

3. The continuous elution apparatus for preparing heparin sodium according to claim 2, characterized in that, The support ring (51) is provided with a guide groove (54), which is V-shaped. A limit groove (55) is provided at the upper end of the bend of the guide groove (54). A slider (56) is provided on the connecting plate (52), and the slider (56) is slidably connected in the guide groove (54).

4. The continuous elution apparatus for preparing heparin sodium according to claim 2, characterized in that, A reset spring (57) is provided between the second filter plate (4) and the support ring (51), and the reset spring (57) is located inside the receiving groove (53).

5. The continuous elution apparatus for preparing heparin sodium according to claim 2, characterized in that, A rotating ring (6) is provided on the bottom inner side of the receiving groove (53) and the lower end face of the second filter plate (4). A limiting ring (7) is provided on the rotating ring (6). The two limiting rings (7) are rotatably connected to the bottom inner side of the receiving groove (53) and the lower end face of the second filter plate (4), respectively. The cross-section of the limiting ring (7) is an isosceles trapezoid.

6. The continuous elution apparatus for preparing heparin sodium according to claim 1, characterized in that, The outlet tube of the continuous elution column (1) is equipped with two control knobs (9), and the positions of the two control knobs (9) correspond to each other.

7. The continuous elution apparatus for preparing heparin sodium according to claim 3, characterized in that, Multiple guide grooves (54) and multiple connecting plates (52) are provided, and the positions of the multiple connecting plates (52) correspond to the positions of the multiple guide grooves (54).

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