An apparatus for reacting an aprepitant intermediate
By employing a double-layer structure, combined stirring mechanism, and inert gas barrier in the aspirin intermediate reaction vessel, the problem of uneven mixing in the synthesis of aspirin intermediates in traditional reaction vessels has been solved, achieving more efficient reaction control and equipment durability.
Patent Information
- Application Number
- CN202521647082.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-08-05
- Publication Date
- 2026-08-25
- Estimated Expiration
- 2035-08-05
AI Technical Summary
Existing glass-lined reactors have problems in the synthesis of aspirin intermediates, where the stirring system is difficult to achieve uniform mixing throughout the reactor in high-viscosity systems or multiphase reactions, leading to excessively high local concentrations and side reactions.
The reactor adopts a double-layer structure, with the inner layer being a glass-lined double-glazed structure. It combines a combined stirring mechanism and an inert gas barrier, using axial and radial stirring impellers and equipped with a gas disperser to enhance the mixing effect. The mechanical seal and inert gas barrier improve the sealing performance.
It achieves uniform mixing of aprepitant intermediates, reduces side reactions, improves production efficiency, extends equipment life, and adapts to multi-step reaction requirements.
Smart Images
Figure CN224672694U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of reaction device technology, specifically to an aprepitant intermediate reaction device. Background Technology
[0002] As a key chemical product in the synthesis of aspirin, the production quality of intermediates directly determines the safety and efficacy of the final drug. These synthetic reactions typically involve multiple complex processes, including halogenation, hydrogenation reduction, low-temperature lithiation, and high-temperature condensation, and often require operation in highly corrosive media and under strict temperature control conditions (-80°C to 300°C).
[0003] Existing glass-lined reactors combine the corrosion resistance of glass with the mechanical strength of metal by sintering a high borosilicate glass glaze layer onto a metal substrate (usually carbon steel). They have become one of the standard equipment for the production of pharmaceutical intermediates. However, there are still defects in the synthesis of aspirin intermediates. Traditional stirring systems are prone to dead zones in high-viscosity systems or multiphase reactions. Conventional radial flow impellers are difficult to achieve uniform mixing throughout the reactor, resulting in excessively high local concentrations and side reactions. Utility Model Content
[0004] The purpose of this invention is to provide an aprepitant intermediate reaction device to solve the above problems, which provides uniform mixing, strong corrosion resistance, and improved service life.
[0005] Technical Solution: This utility model provides an aprepitant intermediate reaction device, comprising: a reaction vessel body, a sealing device, a combined stirring mechanism, baffles, and a gas disperser. The reaction vessel body adopts a double-layer structure, with an outer metal substrate and an inner glass-lined enamel layer, the inner glass layer adopting a double-glazed structure. The sealing device includes a sealing cap and an inert gas barrier. The sealing cap is located in the middle of the upper part of the reaction vessel body, and the sealing cap and the reaction vessel body are sealed together to form an annular sealing cavity. The sealing cap is provided with a gas filling port, and the inert gas barrier is filled into the annular sealing cavity through the gas filling port. The combined stirring mechanism includes an axial stirring mechanism, a radial stirring mechanism, and a stirring shaft. The stirring shaft is vertically installed inside the reaction vessel body, with its upper end passing through the sealing cap to the outside. The axial stirring mechanism is located in the middle of the stirring shaft, and the radial stirring mechanism is located at the bottom of the stirring shaft. The baffles are detachable, and several baffles are evenly arranged on the inner wall of the inner layer structure of the reaction vessel body. The gas disperser is located at the bottom of the reaction vessel body.
[0006] Furthermore, in the aforementioned aprepitant intermediate reaction apparatus, the inner glass lining of the reaction vessel body 1 has a double-glazed structure, with the bottom layer being a chromium oxide-containing transition layer and the top layer being a cerium dioxide and silicon dioxide composite material layer.
[0007] Furthermore, in the aforementioned aprepitant intermediate reaction apparatus, after the sealing cap is sealed and installed with the reaction vessel body, a cooling jacket is fitted on the outside, and coolant is circulated into the cooling jacket.
[0008] Furthermore, in the aforementioned aprepitant intermediate reaction device, a support is provided on the upper part of the sealing cap, and a drive mechanism is provided above the support.
[0009] Furthermore, in the aforementioned aprepitant intermediate reaction device, the driving mechanism includes a reducer and a drive motor. The reducer is mounted on a support, and the drive motor is mounted above and connected to the reducer. The stirring shaft passes through the middle of the sealing cover and is connected to the reducer.
[0010] Furthermore, in the aforementioned aprepitant intermediate reaction device, the upper end of the stirring shaft is a drive shaft and the lower part is a driven shaft, and the drive shaft and the driven shaft are connected by a coupling.
[0011] Furthermore, in the aforementioned aprepitant intermediate reaction apparatus, a manhole and a feed inlet are provided on the top of the reactor body, a jacket is provided in the middle of the outer side, an air inlet is provided on the outer bottom side, and a discharge outlet and a medium outlet are provided at the bottom.
[0012] Furthermore, in the aforementioned aprepitant intermediate reaction device, the gas disperser is arranged in a ring shape, the inlet pipe is connected to the inlet, and several outlet holes are arranged alternately on the gas disperser.
[0013] Furthermore, in the aforementioned aprepitant intermediate reaction device, the outer side of the axial stirring mechanism has inclined stirring blades with an inclination angle of 45°-60°, and the radial stirring mechanism has vertical stirring blades.
[0014] Furthermore, in the aforementioned aprepitant intermediate reaction device, an electric regulating valve is installed outside the sealing cap to monitor and maintain the gas pressure inside the sealing chamber, such that the inert gas barrier satisfies Pb=Pr+ΔP, where Pb is the pressure inside the barrier chamber; Pr is the pressure inside the vessel; and ΔP is the positive pressure difference maintained at 0.05-0.2 MPa.
[0015] As can be seen from the above technical solution, this utility model has the following beneficial effects: The aprepitant intermediate reaction device of this utility model has a double-layer structure for the reaction vessel. The glass lining adopts a double-layer glaze structure, which improves the resistance to acid and alkali conditions. The sealing device is a double-layer sealing structure, with mechanical seal and inert gas barrier, which significantly improves the sealing effect and ensures the stable progress of the reaction. A combined stirring mechanism is set, with an inclined impeller at the top to enhance axial flow and a vertical impeller at the bottom to enhance radial flow, so as to make the mixing uniform. The baffle is detachably set on the inner wall of the reaction vessel to enhance turbulence and eliminate vortices. A gas disperser is set at the bottom of the reaction vessel to make the gas uniformly dispersed and improve the reaction rate. It can be adapted to the multi-step reaction of aprepitant intermediate, reduce equipment switching, and improve production efficiency. Attached Figure Description
[0016] Figure 1 This is a schematic diagram of the reaction device for aprepitant intermediate according to the present invention; Figure 2 This is a diagram of the sealing device of this utility model; Figure 3 This is a schematic diagram of the gas disperser of this utility model.
[0017] In the figure: 1. Reactor body; 2. Sealing device; 3. Combined stirring mechanism; 4. Baffle; 5. Gas distributor; 6. Drive mechanism; 21. Sealing cover; 22. Inert gas barrier; 23. Cooling jacket; 212. Gas inlet; 31. Axial stirring mechanism; 32. Radial stirring mechanism; 33. Stirring shaft; 61. Reducer; 62. Drive motor; 331. Drive shaft; 332. Driven shaft; 333. Coupling; 11. Manhole; 12. Feed inlet; 13. Jacket; 14. Air inlet; 15. Discharge outlet; 16. Medium outlet; 51. Gas outlet. Detailed Implementation
[0018] Example 1 like Figure 1-3The apparatus shown is a reaction device for an aprepitant intermediate, comprising: a reaction vessel body 1, a sealing device 2, a combined stirring mechanism 3, a baffle 4, and a gas distributor 5. The reaction vessel body 1 has a double-layer structure, with an outer metal substrate and an inner glass-lined enamel layer, the inner glass layer having a double-glazed structure. The sealing device 2 includes a sealing cap 21 and an inert gas barrier 22. The sealing cap 21 is located in the upper middle part of the reaction vessel body 1, and the sealing cap 21 and the reaction vessel body 1 are sealed together to form an annular sealing cavity. The sealing cap 21 is provided with a gas filling port 212. Gas barrier 22 is introduced into the annular sealed cavity through gas inlet 212; the combined stirring mechanism 3 includes an axial stirring mechanism 31, a radial stirring mechanism 32, and a stirring shaft 33. The stirring shaft 33 is vertically installed inside the reactor body 1, with its upper end passing through the sealing cover 21 to the outside. The axial stirring mechanism 31 is located in the middle of the stirring shaft 33, and the radial stirring mechanism 32 is located at the bottom of the stirring shaft 33; the baffle 4 is detachable, and several baffles 4 are evenly arranged on the inner wall of the inner layer structure of the reactor body 1; the gas distributor 5 is located at the bottom of the reactor body 1. The reactor body 1 adopts a double-layer structure, and the inner glass adopts a double-glaze structure to improve resistance to acid and alkali conditions. The sealing device 2 is a double-layer sealing structure, combining mechanical sealing with inert gas to significantly improve the sealing effect. The combined stirring mechanism 3 ensures uniform mixing, and the gas distributor 5 ensures uniform gas dispersion, thereby increasing the reaction rate.
[0019] like Figure 2 The illustrated apropitant intermediate reaction apparatus, after the sealing cap 21 is sealed and installed with the reaction vessel body 1, has a cooling jacket 23 fitted over its outer side. Coolant flows through the cooling jacket 23, surrounding the sealing area, and cooling slows down the aging of the seal.
[0020] In this embodiment, a bracket is provided on the upper part of the sealing cover 21, and a drive mechanism 6 is provided above the bracket. The drive mechanism 6 includes a reducer 61 and a drive motor 62. The reducer 61 is provided on the bracket, and the drive motor 62 is provided above the reducer 61 and connected to it. The stirring shaft 33 passes through the middle of the sealing cover 21 and is connected to the reducer 61.
[0021] In this embodiment, the inner glass lining of the reactor body 1 has a double-glazed structure, with a chromium oxide-containing transition layer at the bottom and a cerium dioxide and silicon dioxide composite material layer at the top. This improves resistance to alkali brittleness and extends the service life of the equipment.
[0022] Example 2 Based on Example 1, in this example, as Figure 3The apparatus shown is an aprepitant intermediate reaction device. The gas distributor 5 is arranged in a ring shape, and the gas inlet pipe is connected to the gas inlet 14. Several gas outlet holes 51 are arranged alternately on the gas distributor 5. The gas distributor 5 is made of porous sintered metal material, using Hastelloy, and covered with an outer glass protective layer to achieve uniform gas dispersion.
[0023] like Figure 1 The apparatus shown is a reaction device for aprepitant intermediates. The upper end of the stirring shaft 33 is a drive shaft 331, and the lower part is a driven shaft 332. The drive shaft 331 and the driven shaft 332 are connected by a coupling 333.
[0024] In this embodiment, the reactor body 1 is provided with a manhole 11 and a feed inlet 12 on the top, a jacket 13 in the middle of the outer side, an air inlet 14 on the outer side of the bottom, and a discharge outlet 15 and a medium outlet 16 at the bottom.
[0025] In this embodiment, the outer side of the axial stirring mechanism 31 is an inclined stirring blade with an inclination angle of 45°-60°. Combined with the bottom gas disperser 5, it promotes the dispersion of axial flow hydrogen bubbles throughout the entire reactor, improves catalyst contact efficiency, avoids solid product deposition, accelerates heat transfer, and prevents local overheating. The radial stirring mechanism 32 has vertical stirring blades, which increases radial flow, prevents radial shearing from adhering to the wall, and can quickly disperse raw materials.
[0026] In this embodiment, an electrically adjustable valve is installed outside the sealing cap 21 to monitor and maintain the gas pressure inside the sealing cavity, ensuring that the inert gas barrier 22 satisfies Pb = Pr + ΔP, where Pb is the barrier cavity pressure, Pr is the pressure inside the vessel, and ΔP is the positive pressure difference maintained at 0.05-0.2 MPa. Injecting inert gas into the sealing cavity forms a positive pressure barrier, preventing leakage of the reaction medium and protecting the mechanical seal. Nitrogen can be selected for conventional reactions, argon for extreme inertness requirements, and carbon dioxide can be selected to neutralize alkaline vapors to a certain extent in specific alkaline environments.
[0027] It should be noted that the above description is merely a technical solution of the utility model and not a limitation. Although the present utility model has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solution of the utility model without departing from the scope of the present utility model, and all such modifications and substitutions should be covered within the scope of the claims of the present utility model.
Claims
1. An aprepitant intermediate reaction apparatus, characterized in that: include: The reactor body (1) adopts a double-layer structure, with an outer metal substrate and an inner glass lining (enamel), and the inner glass adopts a double-glaze structure. The sealing device (2) includes a sealing cover (21) and an inert gas barrier (22). The sealing cover (21) is located in the middle of the upper part of the reactor body (1). The sealing cover (21) and the reactor body (1) are sealed together to form an annular sealing cavity. The sealing cover (21) is provided with an air inlet (212). The inert gas barrier (22) is filled into the annular sealing cavity through the air inlet (212). The combined stirring mechanism (3) includes an axial stirring mechanism (31), a radial stirring mechanism (32), and a stirring shaft (33). The stirring shaft (33) is vertically installed inside the reactor body (1), with its upper end passing through the sealing cover (21) to enter the outside. The axial stirring mechanism (31) is located in the middle of the stirring shaft (33), and the radial stirring mechanism (32) is located at the bottom of the stirring shaft (33). Baffle (4), the baffle (4) is detachable, and several baffles (4) are evenly arranged on the inner wall of the inner layer structure of the reactor body (1); Gas disperser (5) is located at the bottom of the reactor body (1).
2. The aprepitant intermediate reaction apparatus according to claim 1, characterized in that: The inner glass lining of the reactor body (1) has a double-glazed structure, with a bottom layer containing chromium oxide and a top layer of cerium dioxide and silicon dioxide composite material.
3. The aprepitant intermediate reaction apparatus according to claim 1, characterized in that: After the sealing cover (21) is sealed and installed with the reactor body (1), a cooling jacket (23) is fitted on the outside, and coolant is introduced into the cooling jacket (23).
4. The aprepitant intermediate reaction apparatus according to claim 1, characterized in that: A bracket is provided on the upper part of the sealing cover (21), and a driving mechanism (6) is provided above the bracket.
5. The aprepitant intermediate reaction apparatus according to claim 4, characterized in that: The drive mechanism (6) includes a reducer (61) and a drive motor (62). The reducer (61) is mounted on a bracket, and the drive motor (62) is mounted above the reducer (61) and connected to it. The stirring shaft (33) passes through the middle of the sealing cover (21) and is connected to the reducer (61).
6. The aprepitant intermediate reaction apparatus according to claim 5, characterized in that: The upper end of the stirring shaft (33) is a drive shaft (331), and the lower part is a driven shaft (332). The drive shaft (331) and the driven shaft (332) are connected by a coupling (333).
7. The aprepitant intermediate reaction apparatus according to claim 1, characterized in that: The reactor body (1) is provided with a manhole (11) and a feed inlet (12) on the top, a jacket (13) in the middle of the outer side, an air inlet (14) on the outer side of the bottom, and a discharge outlet (15) and a medium outlet (16) at the bottom.
8. The aprepitant intermediate reaction apparatus according to claim 1, characterized in that: The gas disperser (5) is arranged in a ring shape, with the air inlet pipe connected to the air inlet (14), and several air outlets (51) are arranged alternately on the gas disperser (5).
9. The aprepitant intermediate reaction apparatus according to claim 1, characterized in that: The outer side of the axial stirring mechanism (31) is an inclined stirring blade with an inclination angle of 45°-60°, and the radial stirring mechanism (32) is a vertical stirring blade.
10. The aprepitant intermediate reaction apparatus according to claim 1, characterized in that: An electric regulating valve is provided outside the sealing cover (21) to monitor and maintain the gas pressure in the sealing cavity, so that the inert gas barrier (22) satisfies Pb=Pr+ΔP, where Pb: barrier cavity pressure; Pr: pressure inside the vessel; ΔP: maintain a positive pressure difference of 0.05-0.2 MPa.