NEW ANALOGUES AS REGULATORS OF ANDROGONE RECEPTORS AND GLUCOCORTICOD RECEPTORS

Abstract

The present invention relates to novel dihydropyridine derivatives of the chemical formula (I) as modulators of nuclear receptors selected from androgen and glucocorticoid receptors, to a process for their preparation, to pharmaceutical compositions containing said compounds and to the use of said compounds for the manufacture of pharmaceutical preparations for the treatment of pathological conditions or diseases that can be improved by modulating the androgen receptor and / or the glucocorticoid receptor, selected from cancer, metastatic cancer, benign prostatic hyperplasia, polycystic ovary syndrome (PCOS), hair loss, hirsutism, acne, hypogonadism, muscle-wasting diseases, cachexia, Cushing's syndrome, weight gain induced by antipsychotic drugs, post-traumatic stress disorder and alcoholism.