Method for determining a measure of waste rate and mass spectrometry system

By using SNR and m/z-dependent corrections, the method addresses the limitations of existing FTICR CCS determination methods, enabling accurate and precise CCS measurements across a broad mass range, enhancing measurement reliability and compatibility with chromatography techniques.

DE102022128278B4Active Publication Date: 2026-06-11THERMO FISHER SCI BREMEN
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Patent Information

Authority / Receiving Office
DE · DE
Patent Type
Patents
Current Assignee / Owner
THERMO FISHER SCI BREMEN
Filing Date
2022-10-25
Publication Date
2026-06-11

AI Technical Summary

Technical Problem

Existing methods for determining collision cross-section areas (CCS) in Fourier transform ion cyclotron resonance mass spectrometry (FTICR) are limited by the need to isolate specific ions for intensity, leading to unreliable measurements over broad mass ranges and inability to determine CCS in parallel with mass-to-charge ratio (m/z) determination, especially when ion intensities are low.

Method used

The method employs signal-to-noise ratio (SNR) and m/z-dependent corrections to improve decay time measurements, allowing for parallel determination of CCS across a broad mass range, using techniques like liquid chromatography (LC) or gas chromatography (GC), and incorporates hardware for varying gas pressure to enhance measurement accuracy.

Benefits of technology

This approach enables accurate and precise determination of CCS values across a wide mass range, compatible with high-dynamic-range scans, improving measurement reliability and enabling online analysis.

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Abstract

Method for determining a measure of the decay rate of an ion sample subjected to mass analysis in a mass analyzer with mirror current detection, the method comprising: Receiving a detection signal for the ion sample from a detection of transients of the ion sample obtained using the mass analyzer, wherein the detection signal for the ion sample has a temporal decay rate; and Determining the measure for the decay rate of the ion sample based on an extrapolated resolution for the ion sample, where the extrapolated resolution is an expected resolution of the detection signal under conditions where the temporal decay rate of the detection signal for the ion sample is dominated by collision effects, where the extrapolated resolution for the ion sample is an expected resolution of the detection signal under conditions where the resolution of the detection signal is stable with respect to increasing the number of sample ions in the sample ion cloud used to generate the detection signal for the ion sample, wherein the extrapolated resolution for the ion sample is determined from an extrapolated function that provides an expected resolution of the detection signal under conditions dominated by collision effects, wherein the extrapolated function is determined based on several measures of resolution and several measures of signal intensity that were not obtained under conditions dominated by collision effects.
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