Dental hygiene products

Abstract

Toothpaste composition, comprehensive (i) 0.01 to 1% by weight cinnamon oil, (ii) 0.003 to 0.3 wt% Trifolium pratense extract, (iii) 0.006 to 0.6 wt% yarrow extract, (iv) 0.01 to 1% by weight of myrrh tincture, and (v) 1 to 25 wt% montmorillonite, wherein the toothpaste composition has a pH of 7 to 9.

Description

Technical area

[0001] The present invention relates to compositions for dental hygiene and dental prevention and treatment. In particular, the present invention relates to natural compositions for preventing or alleviating gingivitis, as well as compositions for use in a method for treating and / or preventing gingivitis. Background of the invention

[0002] Studies have shown that many people have problems with their gums, making effective dental and oral hygiene, as well as the prevention and treatment of gingivitis and other dental problems, of considerable importance in everyday life. Periodontal inflammation (periodontitis, gum disease) is by far the most common disease in Germany. This is according to data from a recent oral health study: 52% of people over the age of 35 are affected by periodontitis, and among seniors, the figure rises to 90%. Periodontitis is one of the most common chronic diseases worldwide. In Germany, approximately 11.5 million people suffer from a severe form of this widespread disease (Micheelis, W. et al., Third German Oral Health Study (DMS III): Results, Trends and Problem Analyses Based on Population-Representative Samples in Germany 1997. Deutscher Ärzte-Verlag, Cologne 1999).

[0003] It's worth noting that conventional toothpastes can contain a number of ingredients that are harmful to health. Although toothpaste isn't usually swallowed, its ingredients are absorbed through the oral mucosa and thus enter the bloodstream particularly quickly. This is particularly aggravated by the polyethylene glycols sometimes contained in toothpastes, as these promote the permeability of the oral mucosa, allowing harmful substances to be absorbed more easily.

[0004] Sodium lauryl sulfate (SLS or SDS) is particularly controversial because it is considered allergenic and a skin irritant. Its use can lead to or promote the development of small, painful mouth ulcers (canker sores). Titanium dioxide, which is used to whiten toothpaste, is also not considered safe, as it is suspected of being harmful to health, mutagenic, and carcinogenic. Parabens, which are very similar in structure to the female sex hormone estrogen, are similarly concerning, leading to fears that they can disrupt people's hormonal balance. There are also concerns about the substance chlorhexidine, which inhibits caries bacteria. With prolonged use, this substance not only discolors teeth brownishly, but is also suspected of disrupting the natural oral flora. The anti-cavity ingredient cetylpyridinium chloride is classified as a strong mucosal irritant.The antibacterial agent triclosan can trigger contact allergies and has shown harmful effects on the hormonal system in animal studies.

[0005] Another key ingredient in many toothpastes is fluoride. When swallowed regularly in small amounts, fluoride has no noticeable acute toxic effect. However, chronic fluoride intake can be harmful and lead to a condition called fluorosis, which initially manifests as harmless discoloration of the tooth enamel and can lead to, among other things, skeletal and especially joint problems.

[0006] Abrasives can also be problematic because they can damage tooth enamel. Dental care products with an RDA (relative dentin abrasion) above 80 should therefore be avoided.

[0007] Furthermore, several commonly used ingredients are considered environmentally harmful or at least ecologically questionable. For example, common toothpastes can also contain microplastics, particularly in the form of polyethylene and / or polypropylene.

[0008] Known from the prior art is document WO 2022 / 082218, which discloses dermatological compositions that may contain, among other ingredients, cinnamon oil, myrrh oil, and red clover extract, as well as their applications, particularly with regard to improving damaged skin as a result of a bacterial infection or, more generally, as a result of environmental influences such as sunlight (UV radiation). Furthermore, an example of a mouthwash solution is disclosed that contains, among other ingredients, cinnamon- and peppermint-based flavors and fluoride. Fluoride is used, in particular, to prevent caries.

[0009] Document DE 10 2005 019 653 A1 discloses plant extracts that can be used to treat halitosis, gingivitis, or periodontitis. In particular, the function of the cosmetic and pharmaceutical compositions is to inhibit the enzyme methionine gamma-lyase (METase). The disclosed plant extracts include, for example, red clover extract, but also cinnamon oil, which can function as an aromatic oil. Furthermore, binding agents or consistency regulators, such as montmorillonite clays, may be present. Furthermore, a preferred pH range between 7.5 and 9 is disclosed, which can be achieved by adding acid.

[0010] Document WO 2012 / 174091 A2 discloses body care compositions that may contain, among other ingredients, flavonoids, which may be obtained, for example, by extraction from red clover. Furthermore, the compositions may contain certain plant extracts with antibacterial properties, such as cinnamon oil, in a concentration range between 0.0001 and 30 wt.%.

[0011] Document US 2022 / 0331344 A1 discloses oral compositions comprising at least one botanical extract of a psychotropic macrofungus and at least one mouthfeel enhancer. For example, the document describes methods and materials for the manufacture of dissolvable lozenges, disclosing cinnamon oil, among others, as a suitable mouthfeel enhancer.

[0012] Document DE 10 2010 040 567 A1 discloses cosmetic agents and compositions comprising microcapsules that are low in or free of formaldehyde. Among other ingredients, cinnamon oil is disclosed as a long-lasting fragrance, red clover extract as a source of isoflavones or isoflavone glycosides, and yarrow extract as a usable plant extract. Furthermore, the cosmetic compositions can contain, for example, antimicrobial, antiperspirant, skin-lightening, moisturizing, and / or anti-caries or anti-tartar active ingredients.

[0013] The document DE 10 2005 014 687 A1 discloses compositions which in particular comprise human beta-defensin 2 as an antimicrobial active ingredient. The compositions are in particular selected from cosmetic and / or pharmaceutical compositions, washing and / or cleaning agents, water treatment agents and cooling lubricants. Red clover extract is disclosed as a possible source of isoflavones or their glycosides. Yarrow is named as an example of a plant extract. Furthermore, peppermint oil, cinnamon oil and myrrh extract are disclosed, as well as the use of organic or inorganic thickeners in amounts of up to 2 wt.% in total with respect to the total composition. In this context, montmorillonite clays are disclosed, among others, as representatives of the phyllosilicates, which can be used as binders and consistency regulators. In addition, substances such asα- and β-hydroxycarboxylic acids are added to regulate the pH of the composition.

[0014] Furthermore, document DE 102018 126 513 A1 discloses oral or dental care cleansers containing at least one mineral of plant origin. Examples of extracts mentioned in this context include chamomile, yarrow, peppermint, cinnamon, horsetail, and myrrh. Clay minerals such as montmorillonite and kaolin are also described, preferably comprising between 10 and 40% by weight of the total composition. Furthermore, a basic pH value is to be maintained on the treated surfaces, particularly tooth surfaces, by leaving the plant oil as a protective layer on the (tooth) surface, thus protecting it from negative acid influences.

[0015] Considering the multitude of substances that are harmful to health, the increasing importance of environmentally friendly and sustainable products, as well as the prevalence of gum problems, there is a clear need for toothpastes that are safe and sustainable, while at the same time enabling effective prevention and treatment of gum problems, especially gingivitis, preferably without the disadvantages described above.

[0016] A technical object of the invention is therefore to provide a toothpaste composition which is harmless to health and sustainable, and which at the same time enables effective prevention and treatment of gum problems, especially gingivitis.

[0017] The object is achieved by a toothpaste composition according to claim 1. Further advantageous embodiments of the present invention are the subject of the dependent claims. Summary of the invention

[0018] A toothpaste composition is provided comprising (i) 0.01 to 1 wt.%, preferably 0.025 to 0.5 wt.%, particularly preferably 0.05 to 0.2 wt.%, cinnamon oil, and (ii) 0.003 to 0.3 wt.%, preferably 0.005 to 0.01 wt.%, particularly preferably 0.01 to 0.05 wt.%, Trifolium pratense (meadow clover / red clover) extract, and (iii) 0.006 to 0.6 wt.%, preferably 0.01 to 0.15 wt.%, particularly preferably 0.03 to 0.09 wt.%, yarrow extract, preferably Achillea millefolium extract, and (iv) 0.01 to 1 wt.%, preferably 0.05 to 0.2 wt.%, particularly preferably 0.075 to 0.125 % by weight of myrrh tincture, preferably Commiphora myrrha tincture, and (v) 1 to 25% by weight, preferably 3 to 15% by weight, particularly preferably 5 to 10% by weight of montmorillonite.

[0019] Such a composition is pH-stabilizing (thus avoiding an acidic pH) and anti-inflammatory. Furthermore, it is a natural or essentially natural toothpaste composition.

[0020] Trifolium pratense is used for its content of isoflavones and rhodanide; isoflavones have antioxidant effects, while rhodanide has anti-inflammatory effects and has been shown to stimulate the humoral immune response.

[0021] At the selected amounts (wt%), the active ingredients do not influence each other.

[0022] In one embodiment, the cinnamon oil is Cinnamomum zeylanicum oil.

[0023] The cinnamon oil of the toothpaste composition according to the invention can consist of cinnamon bark oil, cinnamon leaf oil or a mixture thereof, wherein the cinnamon oil preferably consists of cinnamon leaf oil.

[0024] Trifolium pratense extract comprises and / or consists of an extract from the flowers of Trifolium pratense, preferably Trifolium pratense extract consists of an extract from the flowers of Trifolium pratense.

[0025] In a further embodiment, the amount of components (i) and (ii) in the toothpaste composition is sufficient to impart anti-inflammatory efficacy to the composition.

[0026] The toothpaste composition has a pH of 7 to 9, preferably a pH of 7.5 to 8.5, more preferably a pH of about 8.

[0027] The pH plays a role in our physical health with regard to the progressive behavior of inflammatory parameters. Patients with hyperacidity tend to exhibit more severe inflammatory modalities than others with an average to alkaline pH.

[0028] In a further embodiment, the toothpaste composition (vi) comprises 1 to 25 wt%, preferably 3 to 15 wt%, particularly preferably 5 to 10 wt%, of kaolin.

[0029] Kaolin has a purifying and cleansing effect.

[0030] In yet another embodiment, both components (v) and (vi) are present and together make up 2 to 30 wt.%, preferably 5 to 20 wt.%, particularly preferably 12 to 16 wt.%.

[0031] In yet another embodiment, the toothpaste composition further comprises (vii) 0.003 to 0.3 wt%, preferably 0.005 to 0.075 wt%, more preferably 0.01 to 0.05 wt%, of horsetail extract, preferably Equisetum arvense extract; and / or (viii) 0.003 to 0.3 wt%, preferably 0.005 to 0.075 wt%, more preferably 0.01 to 0.05 wt%, of chamomile extract, preferably Chamomilla recutita extract; and / or (ix) 0.01 to 1 wt%, preferably 0.05 to 0.2 wt%, more preferably 0.075 to 0.125 wt%, of peppermint oil; and / or (x) 30 to 60 wt.%, preferably 40 to 50 wt.%, particularly preferably 44 to 47 wt.%, water.

[0032] Achillea millefolium (yarrow) acts as a bittering agent and is also effective against inflammation and for disinfection.

[0033] Chamomilla recutita is used herein as a synonym for Matricaria chamomilla. Chamomile extract includes and / or consists of an extract from chamomile flower heads.

[0034] Myrrh is used here as a synonym for myrrh resin. Myrrh tincture is preferably made from 1 part myrrh to 5 parts 90% ethanol.

[0035] Commiphora myrrha has astringent, anti-inflammatory, analgesic, disinfectant, hemostatic, and antimicrobial effects—especially for inflammation of the skin and mucous membranes in the mouth and throat area.

[0036] Equisetum arvense also has an anti-inflammatory effect, as well as a firming, strengthening and cleansing effect on the connective tissue.

[0037] Chamomilla recutita extract (chamomile flower extract) has wound-healing, mild antioxidant, anti-inflammatory and antibacterial properties.

[0038] Peppermint oil has antibacterial, anti-inflammatory, analgesic, antiseptic and expectorant properties.

[0039] In yet another embodiment, the toothpaste composition further comprises (xi) 0.03 to 3 wt%, preferably 0.06 to 1 wt%, more preferably 0.1 to 0.5 wt%, of hydrogen peroxide and / or carbamide peroxide.

[0040] In yet another embodiment, the toothpaste composition further comprises one or more excipients, preferably selected from the group consisting of (xii) humectant, preferably sorbitol and / or glycerin; and / or (xiii) filler(s) and / or binder, preferably carboxymethylcellulose and / or microcrystalline cellulose, and / or xanthan gum; and / or (xiv) surfactant(s), preferably sugar surfactants, in particular decyl glucoside, cocamidopropyl betaine and / or sodium lauroyl sarcosinate; and / or (xv) preservative(s), preferably sodium benzoate and / or potassium sorbate; and / or (xvi) fragrance(s), preferably limonene and / or linalool; and / or (xvii, xviii) further substance(s), preferably ethanol, sodium chloride and / or citric acid.

[0041] In yet another embodiment, the toothpaste composition comprises or consists of (i) 0.05 to 0.2 wt% cinnamon oil, and (ii) 0.01 to 0.05 wt% Trifolium pratense extract, and (iii) 0.03 to 0.09 wt% Achillea millefolium extract, and (iv) 0.075 to 0.125 wt% Commiphora myrrha tincture, and (v) 5 to 10 wt% montmorillonite, and / or (vi) 5 to 10 wt% kaolin, and / or (vii) 0.01 to 0.05 wt% Equisetum arvense extract, and / or (viii) 0.01 to 0.05 wt% Chamomilla recutita extract, and / or (ix) 0.075 to 0.125 wt% Peppermint oil, and / or (x) 44 to 47 wt.% water, and / or (xii-a) 15 to 20 wt.% sorbitol, and / or (xii-b) 7 to 10 wt.% glycerin, and / or (xiii-a) 1 to 1.5 wt.% carboxymethylcellulose, and / or (xiii-b) 1 to 1.5 wt.% microcrystalline cellulose, and / or (xiii-c) 0.25 to 0.75 wt.% xanthan, and / or (xiv-a) 2 to 4 wt.% decyl glucoside, and / or (xiv-b) 0.6 to 1.3 wt.% cocamidopropyl betaine, and / or (xiv-c) 0.6 to 1.3 wt.-% sodium lauroyl sarcosinate, and / or (xv-a) 0.2 to 0.3 wt.% sodium benzoate, and / or (xv-b) 0.1 to 0.2 wt.% potassium sorbate, and / or (xvi-a) 0.002 to 0.006 wt.% limonene, and / or (xvi-b) 0.0001 to 0.0003 wt.% linalool, and / or (xviii-a) 0.2 to 0.6 wt.% ethanol, and / or (xviii-b) 0.1 to 0.2 wt.% sodium chloride, and / or (xviii-c) 0.001 to 0.002 wt.% citric acid.

[0042] Montmorillonite (bentonite) is used to detoxify heavy metals.

[0043] In yet another embodiment, the toothpaste composition comprises or consists of (i) 0.05 to 0.2 wt% cinnamon oil, and (ii) 0.01 to 0.05 wt% Trifolium pratense flower extract, and (iii) 0.03 to 0.09 wt% Achillea millefolium extract, and (iv) 0.075 to 0.125 wt% Commiphora myrrha tincture, and (v) 5 to 10 wt% montmorillonite, and / or (vi) 5 to 10 wt% kaolin, and / or (vii) 0.01 to 0.05 wt% Equisetum arvense extract, and / or (viii) 0.01 to 0.05 wt% Chamomilla recutita extract, and / or (ix) 0.075 to 0.125 wt% Peppermint oil, and / or (x) 44 to 47 wt.% water, and / or (xi) 0.1 to 0.5 wt.% carbamide peroxide, and / or (xii-a) 15 to 20 wt.% sorbitol, and / or (xii-b) 7 to 10 wt.% glycerin, and / or (xiii-a) 1 to 1.5 wt.% carboxymethylcellulose, and / or (xiii-b) 1 to 1.5 wt.% microcrystalline cellulose, and / or (xiii-c) 0.25 to 0.75 wt.% xanthan, and / or (xiv-a) 2 to 4 wt.% decyl glucoside, and / or (xiv-b) 0.6 to 1.3 wt.-% cocamidopropyl betaine, and / or (xiv-c) 0.6 to 1.3 wt.% sodium lauroyl sarcosinate, and / or (xv-a) 0.2 to 0.3 wt.% sodium benzoate, and / or (xv-b) 0.1 to 0.2 wt.% potassium sorbate, and / or (xvi-a) 0.002 to 0.006 wt.% limonene, and / or (xvi-b) 0.0001 to 0.0003 wt.% linalool, and / or (xviii-a) 0.2 to 0.6 wt.% ethanol, and / or (xviii-b) 0.1 to 0.2 wt.% sodium chloride, and / or (xviii-c) 0.001 to 0.002 wt.% citric acid.

[0044] In a further aspect, a toothpaste composition as defined in the first aspect is provided for use in a method of treating and / or preventing gingivitis.

[0045] In one embodiment of the second aspect, the method for treating and / or preventing gingivitis involves increasing the pH value in the oral cavity. Definitions

[0046] The term "anti-inflammatory" as used herein describes the suitability and / or property of a toothpaste composition, when used conventionally and regularly, preferably twice daily, orally, to reduce and / or prevent inflammation in the oral cavity and / or in / on the gums, wherein the application preferably takes place over a period of at least 14 days. Inflammation and / or gingivitis within the meaning of the present invention encompasses any increase in suitable inflammatory parameters above a recognized normal value. Methods for determining suitable inflammatory parameters, such as bleeding on probing (BoP), are known to those skilled in the art. In addition to components (i) and (ii), other components can also contribute to the anti-inflammatory effect.In particular, in embodiments in which the toothpaste composition comprises one, several or all of the components (iii), (iv), (vii), (viii), and / or (ix), in addition to the components (i) and (ii), one, several or all of the components (iii), (iv), (vii), (viii), and / or (ix) may also contribute to the anti-inflammatory effect.

[0047] An "extract" or "extraction" as used herein describes a mixture of components obtained from the respective designated plant and / or part of the designated plant using a suitable extraction process. The terminology used herein, particularly with regard to the extracts, oils, and tinctures disclosed herein, corresponding products, and / or production methods, is well known to those skilled in the art. A “natural” toothpaste composition consists of “natural” substances, i.e. of naturally occurring substances and / or at least nature-identical substances and / or derivatives of naturally occurring and / or nature-identical substances (e.g. by carboxymethylation), preferably including products of saponification, including the formation of sugar surfactants and / or cocoamidopropyl betaines, from naturally occurring and / or nature-identical substances (in particular the surfactants described herein as being for use according to the invention). A “substantially natural” toothpaste composition consists of at least 90% by weight, preferably at least 95% by weight, at least 98% by weight or at least 99% by weight of natural substances. A natural or substantially natural toothpaste composition preferably consists of at least 90% by weight or at least 95% by weight.-% from naturally occurring and / or nature-identical substances and in particular and / or additionally does not contain one, several or preferably all of the following components: titanium dioxide, aluminum oxide, sodium lauryl sulfate, chlorhexidine, triclosan (5-chloro-2-(2,4-dichlorophenoxy)-phenol), cetylpyridinium chloride, fluorides, parabens, polyethylene glycols, strong (RDA >80) abrasives and synthetic abrasives such as microplastics made from polyethylene or other plastics, preferably if the respective component was not obtained from a plant. Detailed description

[0048] Due to health and environmental concerns and current trends, it was important to develop an oral care product whose ingredients are formulated to have an anti-inflammatory and pH-stabilizing effect, ideally produced entirely sustainably and from natural ingredients, preferably without artificial flavor enhancers, artificial abrasives, and artificial preservatives.

[0049] In particular, patients whose oral hygiene is normal to above-average, but whose periodontal health remains suboptimal despite proper care and regular dental visits, should be helped to reduce or improve these symptoms. Professional athletes, whose hyperacidity is always a major concern and thus inflammatory parameters in the oral cavity also play a role, should also be provided with a product that alleviates such inflammatory processes. In the normal dental care sector, there are products that, while user-friendly, contain some ingredients that do not primarily have therapeutic value.Furthermore, most commercially available products contain ingredients that, while pleasant in taste and sometimes provide a refreshing sensation for the user, are not free from artificial flavors and flavor enhancers, contain sugar, and are not always sustainably produced. The primary goal of this development was to provide a sustainable product that is plant-based, free of artificial flavors and preservatives, and also has positive effects in terms of anti-inflammatory properties, tartar reduction, and caries protection.

[0050] In a first aspect, as described above, there is provided a toothpaste composition comprising (i) 0.01 to 1 wt%, preferably 0.025 to 0.5 wt%, more preferably 0.05 to 0.2 wt%, of cinnamon oil, and (ii) 0.003 to 0.3 wt%, preferably 0.005 to 0.1 wt%, more preferably 0.01 to 0.05 wt%, of Trifolium pratense (meadow clover / red clover) extract.

[0051] In one embodiment, the cinnamon oil is Cinnamomum zeylanicum oil.

[0052] In a further aspect, a toothpaste composition as defined in the first aspect is provided for use in a method of treating and / or preventing gingivitis.

[0053] In preferred embodiments, the application comprises a usual and regular, preferably twice daily, oral application, wherein the application preferably takes place over a period of at least 14 days.

[0054] In one embodiment of the second aspect, the method for treating and / or preventing gingivitis comprises increasing the pH value in the oral cavity. ExamplesExample 1:

[0055] The following toothpaste compositions were prepared. Table 1: Toothpaste composition (Rev. 00) Share in % by weight Ingredient CAS No. EINECS No. 46,805 Water 7732-18-5 231-791-2 17,5 Sorbitol 50-70-4 200-061-5 14 Montmorillonite 1318-93-0 215-288-5 8,65 Glycerin 56-81-5 200-289-5 5 Erythritol 7541-59-5 231-418-3 2,75 Decylglucoside 54549-25-6 259-218-1 1,25 Carboxymethylcellulose 9004-32-4 - 1,25 Microcrystalline cellulose 9004-34-6 232-674-9 0,9 Cocamidopropyl Betaine 61789-40-0 263-058-8 0,5 Xanthan 11138-66-2 234-394-2 0,4 Ethanol 64-17-5 200-578-6 0,245 Sodium benzoate 532-32-1 208-534-8 0,15 Sodium chloride 7647-14-5 231-598-3 0,1485 Potassium sorbate 24634-61-5 246-376-1 0,1 Commiphora myrrha resin tincture 84929-26-0 284-510-0 0,1 Cinnamomum Zeylanicum Leaf Oil 84649-98-9 283-479-0 0,0958 Mentha Piperita (Peppermint) Oil 8006-90-4 - 0,06 Achillea millefolium extract 84082-83-7 282-030-6 0,03 Trifolium pratense flower extract 85085-25-2 285-356-7 0,03 Equisetum arvense leaf extract 71011-23-9 275-123-8 0,03 Chamomilla recutita flower extract 84082-60-0 282-006-5 0,004 Limonen 5989-27-5 227-813-5 0,0015 citric acid 77-92-9 201-069-1 0,0002 Linalool 78-70-6 201-134-4 Viscosity: 30,000 - 60,000 mPa s pH: about 8 Table 2: Toothpaste composition (Rev. 01) Share in % by weight Ingredient CAS No. EINECS No. 45,905 Water 7732-18-5 231-791-2 17,5 Sorbitol 50-70-4 200-061-5 8,65 Glycerin 56-81-5 200-289-5 7 Montmorillonite 1318-93-0 215-288-5 7 kaolin 1332-58-7 310-194-1 5 Erythritol 7541-59-5 231-418-3 2,75 Decylglucoside 54549-25-6 259-218-1 1,25 Carboxymethylcellulose 9004-32-4 - 1,25 Microcrystalline cellulose 9004-34-6 232-674-9 0,9 Cocamidopropyl Betaine 61789-40-0 263-058-8 0,9 Sodium lauroyl sarcosinate 137-16-6 205-281-5 0,5 Xanthan 11138-66-2 234-394-2 0,4 Ethanol 64-17-5 200-578-6 0,245 Sodium benzoate 532-32-1 208-534-8 0,15 Sodium chloride 7647-14-5 231-598-3 0,1485 Potassium sorbate 24634-61-5 246-376-1 0,1 Commiphora myrrha resin extract 84929-26-0 284-510-0 0,1 Cinnamomum Zeylanicum Leaf Oil 84649-98-9 283-479-0 0,0958 Mentha Piperita (Peppermint) Oil 8006-90-4 - 0,06 Achillea millefolium extract 84082-83-7 282-030-6 0,03 Trifolium pratense flower extract 85085-25-2 285-356-7 0,03 Equisetum arvense leaf extract 71011-23-9 275-123-8 0,03 Chamomilla recutita flower extract 84082-60-0 282-006-5 0,004 Limonen 5989-27-5 227-813-5 0,0015 citric acid 77-92-9 201-069-1 0,0002 Linalool 78-70-6 201-134-4 Viscosity: 30,000 - 60,000 mPa s pH: about 8 Table 3: Toothpaste composition (Rev. 01) with 0.3% carbamide peroxide Share in % by weight Ingredient CAS No. EINECS No. 45,605 Water 7732-18-5 231-791-2 17,5 Sorbitol 50-70-4 200-061-5 8,65 Glycerin 56-81-5 200-289-5 7 Montmorillonite 1318-93-0 215-288-5 7 kaolin 1332-58-7 310-194-1 5 Erythritol 7541-59-5 231-418-3 2,75 Decylglucoside 54549-25-6 259-218-1 1,25 Carboxymethylcellulose 9004-32-4 - 1,25 Microcrystalline cellulose 9004-34-6 232-674-9 0,9 Cocamidopropyl Betaine 61789-40-0 263-058-8 0,9 Sodium lauroyl sarcosinate 137-16-6 205-281-5 0,5 Xanthan 11138-66-2 234-394-2 0,4 Ethanol 64-17-5 200-578-6 0,3 Carbamide peroxide 124-43-6 204-701-4 0,245 Sodium benzoate 532-32-1 208-534-8 0,15 Sodium chloride 7647-14-5 231-598-3 0,1485 Potassium sorbate 24634-61-5 246-376-1 0,1 Commiphora myrrha resin tincture 84929-26-0 284-510-0 0,1 Cinnamomum Zeylanicum Leaf Oil 84649-98-9 283-479-0 0,0958 Mentha Piperita (Peppermint) Oil 8006-90-4 - 0,06 Achillea millefolium extract 84082-83-7 282-030-6 0,03 Trifolium pratense flower extract 85085-25-2 285-356-7 0,03 Equisetum arvense leaf extract 71011-23-9 275-123-8 0,03 Chamomilla recutita flower extract 84082-60-0 282-006-5 0,004 Limonen 5989-27-5 227-813-5 0,0015 citric acid 77-92-9 201-069-1 0,0002 Linalool 78-70-6 201-134-4 Viscosity: 30,000 - 60,000 mPa s pH: about 8 Table 4: Toothpaste composition (Rev. 01) with 0.25% carbamide peroxide Share in % by weight Ingredient CAS No. EINECS No. 45,655 Water 7732-18-5 231-791-2 17,5 Sorbitol 50-70-4 200-061-5 8,65 Glycerin 56-81-5 200-289-5 7 Montmorillonite 1318-93-0 215-288-5 7 kaolin 1332-58-7 310-194-1 5 Erythritol 7541-59-5 231-418-3 2,75 Decylglucoside 54549-25-6 259-218-1 1,25 Carboxymethylcellulose 9004-32-4 - 1,25 Microcrystalline cellulose 9004-34-6 232-674-9 0,9 Cocamidopropyl Betaine 61789-40-0 263-058-8 0,5 Xanthan 11138-66-2 234-394-2 0,9 Sodium lauroyl sarcosinate 137-16-6 205-281-5 0,4 Ethanol 64-17-5 200-578-6 0,25 Carbamide peroxide 124-43-6 204-701-4 0,245 Sodium benzoate 532-32-1 208-534-8 0,15 Sodium chloride 7647-14-5 231-598-3 0,1485 Potassium sorbate 24634-61-5 246-376-1 0,1 Commiphora myrrha resin tincture 84929-26-0 284-510-0 0,1 Cinnamomum Zeylanicum Leaf Oil 84649-98-9 283-479-0 0,0958 Mentha Piperita (Peppermint) Oil 8006-90-4 - 0,06 Achillea millefolium extract 84082-83-7 282-030-6 0,03 Trifolium pratense flower extract 85085-25-2 285-356-7 0,03 Equisetum arvense leaf extract 71011-23-9 275-123-8 0,03 Chamomilla recutita flower extract 84082-60-0 282-006-5 0,004 Limonen 5989-27-5 227-813-5 0,0015 citric acid 77-92-9 201-069-1 0,0002 Linalool 78-70-6 201-134-4 Viscosity: 30,000 - 60,000 mPa s pH: about 8 Example 2: Observational study

[0056] An observational study was conducted over a period of three months in a dental practice with patients who voluntarily agreed to use a product that complied with the claims and complete a study protocol. The toothpaste composition was tested, particularly with regard to its influence on inflammatory parameters and oral pH.

[0057] An improvement in the inflammatory index was observed in 85% of cases, which is particularly interesting given that the study primarily included patients who had previously demonstrated significant periodontal disease. Furthermore, a positive effect on tartar formation, plaque formation, and biofilm adhesion, as well as on caries protection and microflora, was observed. Furthermore, a positive effect on gum and tooth sensitivity was also observed in the subjects. Subjects

[0058] The study was conducted with 20 subjects, 10 male and 10 female, aged approximately 30-50 years: Sports activity several times a week: Yes: 15 subjects No: 5 subjects Previous gum disease: Yes: 16 subjects No: 4 subjects Daily use of dental floss or interdental brushes: Yes: 19 subjects No: 1 subject Known inflammations on or in other parts of the body: Yes: 4 subjects No: 16 subjects Bad breath (if known): Yes 1 subject No 19 subjects Hyperacidity (if known): Yes 7 subjects No 13 subjects

[0059] In the study, the inflammatory parameters were determined in the form of a bleeding and probing index using the computer program Parostatus, and the pH values ​​were measured regularly by the patients during use.

[0060] pH value initial measurement: 6.0 to 6.5: 11 subjects up to 7.0: 6 subjects over 7.0: 3 subjects Application • 14 days of cleaning the toothbrush before applying toothpaste, brushing: 2 minutes in the morning after breakfast and 2 minutes in the evening before going to bed; without using any other dental care products • pH measurement of saliva in the evening after brushing teeth, three times a week Follow-upBOP:

[0061] Improvement of BOP (on average by 5-10%): 16 subjects Consistent BOP: 2 subjects Deterioration of BOP: 2 subjects

[0062] pH measurement: pH increase: 12 subjects pH constant: 8 subjects pH reduction: 1 subject

[0063] The product prevents tartar formation: (Follow-up by the examiner) Definitely not: 0 subjects No: 0 subjects Yes: 11 subjects Definitely yes: 9 subjects

[0064] The product prevents the formation of plaque and reduces the adhesion of biofilm: (Follow-up by the examiner) Definitely not: 0 subjects No: 0 subjects Yes: 12 subjects Definitely yes: 8 subjects

[0065] The product protects against caries, reduces acid production, healthy oral microflora: (Follow-up by the examiner) Definitely not: 1 subject No: 8 subjects Yes: 5 subjects Definitely yes: 6 subjects

[0066] The product protects sensitive gums: Definitely not: 0 subjects No: 0 subjects Neutral: 0 subjects Yes: 16 subjects Definitely yes: 4 subjects

[0067] The product soothes and cares for sensitive gums: Definitely not: 0 subjects No: 0 subjects Neutral: 2 subjects Yes: 13 subjects Definitely yes: 5 subjects

[0068] The product relieves tooth sensitivity and cares for sensitive teeth: Definitely not: 0 subjects No: 2 subjects Neutral: 2 subjects Yes: 12 subjects Definitely yes: 4 subjects

Claims

[1] Toothpaste composition comprising (i) 0.01 to 1% by weight cinnamon oil, (ii) 0.003 to 0.3% by weight of Trifolium pratense extract, (iii) 0.006 to 0.6% by weight of yarrow extract, (iv) 0.01 to 1% by weight of myrrh tincture, and (v) 1 to 25 wt% montmorillonite, wherein the toothpaste composition has a pH of 7 to 9. [2] Toothpaste composition according to claim 1, wherein (i) cinnamon oil is present in a concentration of 0.025 to 0.5% by weight, preferably 0.05 to 0.2% by weight, and (ii) Trifolium pratense extract is present in a concentration of 0.005 to 0.1% by weight, preferably 0.01 to 0.05% by weight. [3] A toothpaste composition according to claim 1 or 2, wherein the cinnamon oil is Cinnamomum Zeylanicum oil. [4] Toothpaste composition according to any one of the preceding claims, further comprising (vi) 1 to 25% by weight, preferably 3 to 15% by weight, particularly preferably 5 to 10% by weight, of kaolin. [5] Toothpaste composition according to claim 4, wherein the components (v) and (vi) are present and together make up 2 to 30 wt.%, preferably 5 to 20 wt.%, particularly preferably 12 to 16 wt.%. [6] Toothpaste composition according to any one of the preceding claims, further comprising at least one of the following components (vii) 0.003 to 0.3% by weight, preferably 0.005 to 0.075% by weight, particularly preferably 0.01 to 0.05% by weight, horsetail extract, preferably Equisetum arvense extract; (viii) 0.003 to 0.3% by weight, preferably 0.005 to 0.075% by weight, particularly preferably 0.01 to 0.05% by weight, of chamomile extract, preferably Chamomilla recutita extract; (ix) 0.01 to 1% by weight, preferably 0.05 to 0.2% by weight, particularly preferably 0.075 to 0.125% by weight, peppermint oil; (x) 30 to 60 wt.%, preferably 40 to 50 wt.%, particularly preferably 44 to 47 wt.%, of water, wherein the content of yarrow extract is preferably 0.01 to 0.15 wt.%, particularly preferably 0.03 to 0.09 wt.% and the yarrow extract is preferably Achillea millefolium extract. [7] Toothpaste composition according to any one of the preceding claims, further comprising (xi) 0.03 to 3 wt.%, preferably 0.06 to 1 wt.%, particularly preferably 0.1 to 0.5 wt.%, of hydrogen peroxide and / or carbamide peroxide. [8] Toothpaste composition according to any one of the preceding claims, further comprising one or more excipients, preferably selected from the group consisting of (xii) humectants, preferably sorbitol and / or glycerin; (xiii) filler(s) and / or binder(s), preferably carboxymethylcellulose and / or microcrystalline cellulose, and / or xanthan gum; (xiv) surfactant(s), preferably sugar surfactants, in particular decyl glucoside, and / or cocamidopropyl betaine and / or sodium lauroyl sarcosinate; (xv) preservative(s), preferably sodium benzoate and / or potassium sorbate; (xvi) fragrance(s), preferably limonene and / or linalool; (xvii) sweeteners, preferably erythritol; (xviii) other substance(s), preferably ethanol, sodium chloride and / or citric acid. [9] Toothpaste composition according to any one of the preceding claims, comprising or consisting of (i) 0.05 to 0.2% by weight of cinnamon oil, and (ii) 0.01 to 0.05% by weight of Trifolium pratense extract, and (iii) 0.03 to 0.09% by weight of Achillea millefolium extract, and (iv) 0.075 to 0.125% by weight of Commiphora myrrha tincture, and (v) 5 to 10 wt% montmorillonite, and (vi) 5 to 10 wt% kaolin, and (vii) 0.01 to 0.05% by weight of Equisetum arvense extract, and (viii) 0.01 to 0.05% by weight of Chamomilla recutita extract, and (ix) 0.075 to 0.125 wt% peppermint oil, and (x) 44 to 47 wt% water, and (xii-a) 15 to 20 wt% sorbitol, and (xii-b) 7 to 10 wt% glycerol, and (xiii-a) 1 to 1.5 wt% carboxymethylcellulose, and (xiii-b) 1 to 1.5 wt% microcrystalline cellulose, and (xiii-c) 0.25 to 0.75 wt% xanthan, and (xiv-a) 2 to 4 wt% decyl glucoside, and (xiv-b) 0.6 to 1.3 wt% cocamidopropyl betaine, and (xiv-c) 0.6 to 1.3 wt% sodium lauroyl sarcosinate, and (xv-a) 0.2 to 0.3 wt% sodium benzoate, and (xv-b) 0.1 to 0.2 wt% potassium sorbate, and (xvi-a) 0.002 to 0.006 wt.% limonene, and (xvi-b) 0.0001 to 0.0003 wt.% linalool, and (xvii) 3 to 7 wt% erythritol, and (xviii-a) 0.2 to 0.6 wt% ethanol, and (xviii-b) 0.1 to 0.2 wt% sodium chloride, and (xviii-c) 0.001 to 0.002 wt% citric acid. [10] Toothpaste composition according to any one of the preceding claims, comprising or consisting of (i) 0.05 to 0.2% by weight of cinnamon oil, and (ii) 0.01 to 0.05% by weight of Trifolium pratense extract, and (iii) 0.03 to 0.09% by weight of Achillea millefolium extract, and (iv) 0.075 to 0.125% by weight of Commiphora myrrha tincture, and (v) 5 to 10 wt% montmorillonite, and (vi) 5 to 10 wt% kaolin, and (vii) 0.01 to 0.05% by weight of Equisetum arvense extract, and (viii) 0.01 to 0.05% by weight of Chamomilla recutita extract, and (ix) 0.075 to 0.125 wt% peppermint oil, and (x) 44 to 47 wt% water, and (xi) 0.1 to 0.5 wt% carbamide peroxide, and (xii-a) 15 to 20 wt% sorbitol, and (xii-b) 7 to 10 wt% glycerol, and (xiii-a) 1 to 1.5 wt% carboxymethylcellulose, and (xiii-b) 1 to 1.5 wt% microcrystalline cellulose, and (xiii-c) 0.25 to 0.75 wt% xanthan, and (xiv-a) 2 to 4 wt% decyl glucoside, and (xiv-b) 0.6 to 1.3 wt% cocamidopropyl betaine, and (xiv-c) 0.6 to 1.3 wt% sodium lauroyl sarcosinate, and (xv-a) 0.2 to 0.3 wt% sodium benzoate, and (xv-b) 0.1 to 0.2 wt% potassium sorbate, and (xvi-a) 0.002 to 0.006 wt.% limonene, and (xvi-b) 0.0001 to 0.0003 wt.% linalool, and (xvii) 3 to 7 wt% erythritol, and (xviii-a) 0.2 to 0.6 wt% ethanol, and (xviii-b) 0.1 to 0.2 wt% sodium chloride, and (xviii-c) 0.001 to 0.002 wt% citric acid. [11] Toothpaste composition according to any one of the preceding claims, for use in the treatment and / or prevention of gingivitis.