5-[(2,4-DINITROPHENOXY)METHYL]-1-METHYL-2-NITRO-L H-IMIDAZOLE AND ITS PHARMACEUTICAL USE
Patent Information
- Application Number
- DE602018090510
- Authority / Receiving Office
- DE · DE
- Patent Type
- Patents
- Current Assignee / Owner
- Priority Date
- 2017-11-13
- Filing Date
- 2018-01-05
- Publication Date
- 2026-04-08
- Estimated Expiration
- 2038-01-05
AI Technical Summary
Existing chemical uncouplers like 2,4-dinitrophenol (DNP) are toxic and pose safety concerns for treating obesity and diabetes-related conditions by increasing energy expenditure without generating ATP, necessitating the development of safer mitochondrial uncouplers.
Development of novel phenyl derivatives, specifically 5-[(2,4-dinitrophenoxy)methyl]-1-methyl-2-nitro-1H-imidazole compounds, which regulate mitochondria activity to reduce adiposity and treat diseases such as diabetes and diabetes-associated complications without the toxicity of DNP.
The novel compounds effectively reduce adiposity, treat diabetes and its complications, and modulate weight gain in mammals by safely increasing energy expenditure, with reduced toxicity and improved safety profiles compared to DNP.