Microcarriers for cell culture
Plasmonic nanoparticles integrated on microcarrier beads facilitate cell culture monitoring and biomarker reporting, ensuring compatible cell growth and expansion, and enabling plasmonic release of cells.
EP4017960B1Active Publication Date: 2026-06-17LUXEMBOURG INSTITUTE OF SCIENCE AND TECHNOLOGY (LIST)
Patent Information
- Authority / Receiving Office
- EP · EP
- Patent Type
- Patents
- Current Assignee / Owner
- LUXEMBOURG INSTITUTE OF SCIENCE AND TECHNOLOGY (LIST)
- Filing Date
- 2020-08-18
- Publication Date
- 2026-06-17
AI Technical Summary
Technical Problem
Existing microcarriers for cell culture lack the ability to integrate sensing functions for monitoring cell health and reporting biomarkers, while maintaining optimal conditions for cell adhesion and proliferation.
Method used
Integration of plasmonic nanoparticles on the surface of microcarrier beads, which are electrostatically attached to a hydrogel matrix, allowing for optical detection methods like surface plasmon resonance and surface-enhanced Raman spectroscopy to monitor cell interactions and biomarkers.
Benefits of technology
Enables effective cell culture monitoring and biomarker reporting without adversely affecting cell behavior, while maintaining cell expansion and migration capabilities, and providing a platform for plasmonic release of cells.
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Abstract
A cell culture microcarrier bead is proposed. The microcarrier bead comprises a bead body having its surface flecked with plasmonic nanoparticles. In a second aspect, the invention relates to a cell culture reactor, containing a cell culture medium and the proposed microcarrier beads. A third aspect of the invention concerns a method for observing living cells on such microcarrier beads. Yet a further aspect of the invention relates to a method for packing nanoparticles on a carrier body.
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