Ligand compounds for e3 ubiquitin ligase, protein degraders developed on basis of ligand compounds, and uses thereof

Abstract

The present disclosure provides compounds of Formula (I) and (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof, and uses thereof. The present disclosure also provides pharmaceutical compositions comprising, as an active ingredient, the compounds of Formula (I) and (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof, and uses thereof.

Description

Technical Field

[0001] The present disclosure relates to cereblon (CRBN) E3 ubiquitin ligase ligand compounds of Formula (I), protein degrader compounds of Formula (II) comprising the same, and their applications. The CRBN E3 ubiquitin ligase ligand compounds can effectively treat or prevent cereblon protein mediated diseases or disorders. The protein degrader compounds of Formula (II) can effectively treat or prevent diseases or disorders associated with the proteins degraded.Background

[0002] Bifunctional proteolysis-targeting drugs consist of three moieties, one end of which is a ligand warhead that can bind to a specific target protein, and the other end is a small molecule ligand of E3 ubiquitin ligase, both of which are connected together through linkers of different lengths and categories located in the middle. The bifunctional proteolysis-targeting small molecules can utilize the binding effects of the ligands at both ends to simultaneously bind to a specific target protein and E3 ubiquitin ligase, thereby recruiting E3 ubiquitin ligase to the vicinity of the specific target protein and enabling E3 ubiquitin ligase to ubiquitinate the target protein. The polyubiquitinated target protein will be recognized and degraded by proteasomes in the body. The biggest difference between the bifunctional proteolysis-targeting drugs and traditional small molecule-based inhibitor drugs is that the former mobilize the entire cell as a drug effector unit. This drug action mode only requires small molecule drugs to briefly bind to the target protein and tag it for degradation. Therefore, a low drug dose can meet the requirements, greatly reducing the risk of off-target effects, and potentially eliminating tumor progression caused by abnormal expression of driver genes and drug resistance caused by acquired mutations in driver genes.

[0003] The E3 ubiquitin ligases involved in the design of proteolysis-targeting drugs include over 500 different proteins, each with a distinct cellular expression profile, and can be classified into multiple categories based on the structural elements related to their E3 functional activity. Currently, only a few ligases have been successfully applied in preclinical degraders research. Among them, Cereblon (CRBN) E3 ubiquitin ligase is one of the most widely used E3 ubiquitin ligases. The known ligands for CRBN-type E3 ubiquitin ligase (CRBN ligands) include thalidomide and its analogs pomalidomide and lenalidomide, all of which possess a phthalimide backbone. CRBN-type E3 ubiquitin ligase ligands can also act as molecular glues to induce the degradation of specific proteins. Cereblon (CRBN) forms a functional E3 ubiquitin ligase complex with damaged DNA binding protein 1 (DDB1) and Cullin 4A, where CRBN serves as the substrate receptor. Molecular glue degraders like thalidomide bind to CRBN, inducing it to recognize new substrate proteins. The binding leads to the ubiquitination of these proteins, followed by their recognition and degradation by proteasomes.

[0004] CRBN ligands have been widely used in protein degradation, and a series of small molecules protein degraders based on CRBN ligands, which utilize the function of the CRBN E3 ubiquitin ligase complex, have gradually been developed. Since CRBN ligands can serve not only as molecular glue degraders to induce the degradation of different substrate proteins but also as a component of bifunctional proteolysis-targeting drugs to achieve effective degradation of specific pathogenic proteins, and given the unavoidable side effects and drug resistance issues associated with various existing domides compounds, such as thalidomide, it is of great significance to design novel and optimized E3 ubiquitin ligase ligands and study their binding ability to CRBN and evaluate their biological activity. Furthermore, these E3 ubiquitin ligase ligands can potentially be applied in bifunctional proteolysis-targeting small molecules.

[0005] Therefore, there is an urgent need for a series of novel CRBN E3 ubiquitin ligase ligands that can serve as effective molecular glue degraders and can also be further used to synthesize corresponding bifunctional proteolysis-targeting degraders for the treatment and / or prevention of diseases or conditions mediated or associated with the proteins degraded.Summary of Invention

[0006] In view of the above, the objectives of the present disclosure are to provide novel CRBN E3 ubiquitin ligase ligands, protein degrader molecules designed based on the novel CRBN E3 ubiquitin ligase ligands and various target protein ligands, as well as their applications and usage methods. The advantages of the compounds of the present disclosure lie in their ability to exhibit a wide range of pharmacological activities through the degradation / inhibition of diverse types or families of pathogenic proteins.

[0007] To achieve the above objectives and other related goals, in one aspect, the present disclosure provides novel CRBN E3 ubiquitin ligase ligands that can themselves act as molecular glues binding to CRBN E3 ligase, and subsequently induce the degradation of CRBN substrate proteins, including but not limited to GSPT1, IKZF1, IKZF2, IKZF3 (Aiolos), and IKZF4 proteins.

[0008] In some embodiments, the novel CRBN E3 ubiquitin ligase ligands of the present disclosure can be compounds of Formula (I): or salts, stereoisomers (including enantiomers), solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof, wherein A represents CO, CH 2 or CD 2 ; R 1 , R 2 , R 3 and R 4 are the same or different and independently represent e.g., hydrogen, deuterium, halogen, optionally deuterated C 1-6 alkyl, optionally deuterated C 1-6 alkoxy, or halogenated C 1-6 alkyl; (R a ) m indicates that benzene ring is substituted with m R a substituents, with each R a being the same or different and independently representing the structure of the following formula: wherein R represents chlorine, bromine, iodine, hydroxy, leaving group, NR 7 R 8 or a group W 1< , wherein R 7 and R 8 are the same or different and independently represent hydrogen, C 1-6 alkyl, C 2-6 alkynyl-C 1-6 alkylene, C 2-6 alkenyl-C 1-6 alkylene, optionally substituted 4- to 15-membered nitrogen-containing heterocyclyl, or R 2a< -R 1a< -, where R 1a< is optionally substituted C 1-6 alkylene or optionally substituted C 2-6 alkenylene, R 2a< represents halogen, amino, hydroxy, carboxyl, C 2-6 alkynyl, C 2-6 alkenyl or a leaving group; and W 1< represents the structure of the following formula: wherein ring W 2< represents optionally substituted nitrogen-containing heterocyclyl, each ring W 3< is the same or different and independently represents optionally substituted nitrogen-containing heterocyclylene, t represents an integer of 1 or 2, and ring W 4< represents optionally substituted aryl, optionally substituted heteroaryl or optionally substituted heterocyclyl; R 5 and R 6 are the same or different and independently represent hydrogen, fluorine, chlorine, bromine, iodine, optionally substituted methyl, or optionally substituted linear or branched C 2-30 alkyl, wherein one or more groups R c and / or one or more groups R d and / or any combination of one or more groups R c and R d are optionally inserted into the backbone carbon chain of the linear or branched C 2-30 alkyl group, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R c , R d , or a combination of R c and R d ; wherein each R c is selected from the group consisting of O, N(R e ), C(O), C(O)O, S(O), S(O) 2 , S(O) 2 NH, NHS(O) 2 , OC(O), C(O)N(R e ), N(R e )C(O), or N(R e )C(O)N(R e ), where each R e independently represents H or C 1-6 alkyl, and in case that two or more groups R c are inserted into the backbone carbon chain of the linear or branched C 2-30 alkyl group, the two or more groups R c are not directly connected to each other; and wherein each R d is selected from the group consisting of cycloalkylene, arylene, heterocyclylene, heteroarylene, alkynylene, alkenylene, or any combination thereof, wherein the cycloalkylene, arylene, heterocyclylene, and heteroarylene are independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C 1-6 alkyl, optionally deuterated C 3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C 1-6 alkoxy, optionally deuterated C 1-6 alkyl-NH-, halogenated C 1-6 alkyl, NH 2 -C 1-6 alkylene, optionally deuterated C 1-6 alkyl-NHC(O)-, optionally deuterated C 1-6 alkyl-C(O)NH-, or any combination thereof; or R and R 5 , together with the carbon atom to which they are connected, form carbonyl group, R 6 represents hydrogen, optionally substituted methyl, or optionally substituted linear or branched C 2-30 alkyl, wherein one or more groups R c and / or one or more groups R d and / or any combination of one or more groups R c and R d are optionally inserted into the backbone carbon chain of the linear or branched C 2-30 alkyl group, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R c , R d , or a combination of R c and R d ; wherein each R c is selected from the group consisting of O, N(R e ), C(O), C(O)O, S(O), S(O) 2 , S(O) 2 NH, NHS(O) 2 , OC(O), C(O)N(R e ), N(R e )C(O), or N(R e )C(O)N(R e ), where each R e independently represents H or C 1-6 alkyl, and in case that two or more groups R c are inserted into the backbone carbon chain of the linear or branched C 2-30 alkyl group, the two or more groups R c are not directly connected to each other; and wherein each R d is selected from the group consisting of cycloalkylene, arylene, heterocyclylene, heteroarylene, alkynylene, alkenylene, or any combination thereof, wherein the cycloalkylene, arylene, heterocyclylene, and heteroarylene are independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C 1-6 alkyl, optionally deuterated C 3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, optionally deuterated C 1-6 alkoxy, optionally deuterated C 1-6 alkyl-NH-, halogenated C 1-6 alkyl, NH 2 -C 1-6 alkylene, optionally deuterated C 1-6 alkyl-NHC(O)-, optionally deuterated C 1-6 alkyl-C(O)NH-, cyano, or any combination thereof; (R b ) n indicates that the benzene ring is substituted with n R b substituents, with each R b being the same or different and independently representing deuterium, halogen, hydroxy, mercapto, nitro, amino, cyano, optionally deuterated C 1-6 alkyl, optionally deuterated C 1-6 alkoxy, halogenated C 1-6 alkyl, optionally substituted C 3-6 cycloalkyl, C 2-6 alkenyl or C 2-6 alkynyl; and m represents an integer of 1, 2, 3, or 4, n represents an integer of 0, 1, 2, or 3, and the sum of m and n is an integer of 1, 2, 3, or 4; wherein when R and R 5 together with the carbon atom to which they are connected form a carbonyl group and R 6 represents hydrogen, m represents an integer of 1, 2, or 3, n represents an integer of 1, 2, or 3, and the sum of m and n is an integer of 2, 3, or 4; with the proviso that the following compounds and compounds of Formula (I') are excluded: and when A represents CH 2 or C(O) and R represents unsubstituted piperazinyl, m represents an integer of 1 and n represents an integer of 0; when A represents CH 2 or C(O) and R a represents H 2 N-CH 2 -, m represents an integer of 1 and n represents an integer of 0; when A represents C(O) and R represents bromine, m represents an integer of 1 and n represents an integer of 0; and the compounds of Formula (I'): wherein in Formula (I'), A represents CH 2 or C(O), and R represents unsubstituted piperidinyl or methylamino substituted piperidinyl.

[0009] In another aspect, the protein degrader compounds of the present disclosure can be compounds of Formula (II):         PBM-R f -LIN-ULM     Formula (II) or salts, stereoisomers (including enantiomers), solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof, wherein PBM-R f - represents a targeting moiety capable of binding protein, ULM represents a E3 ubiquitin ligase ligand moiety, LIN is a linker moiety, and PBM-R f - is covalently bonded to ULM through LIN; ULM represents the structure of Formula (ULM): wherein A represents CO, CH 2 or CD 2 ; R 1 , R 2 , R 3 and R 4 are the same or different and each independently represent hydrogen, deuterium, halogen, optionally deuterated C 1-6 alkyl, optionally deuterated C 1-6 alkoxy, or halogenated C 1-6 alkyl; (R b ) n indicates that the benzene ring is optionally substituted with n R b substituents, with each R b being the same or different and independently representing deuterium, halogen, hydroxy, mercapto, nitro, amino, cyano, optionally deuterated C 1-6 alkyl, optionally deuterated C 1-6 alkoxy, halogenated C 1-6 alkyl, optionally substituted C 3-6 cycloalkyl, C 2-6 alkenyl or C 2-6 alkynyl; n represents an integer of 0, 1, 2 or 3; LIN represents the structure of the following formula: wherein R 5 and R 6 are the same or different and each independently represent hydrogen, fluorine, chlorine, bromine, iodine, optionally substituted methyl, or optionally substituted linear or branched C 2-30 alkyl, wherein one or more groups R c and / or one or more groups R d and / or any combination of one or more groups R c and R d are optionally inserted into the backbone carbon chain of the linear or branched C 2-30 alkyl group, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R c , R d , or a combination of R c and R d ; wherein each R c is selected from the group consisting of O, N(R e ), C(O), C(O)O, S(O), S(O) 2 , S(O) 2 NH, NHS(O) 2 , OC(O), C(O)N(R e ), N(R e )C(O), or N(R e )C(O)N(R e ), where each R e independently represents H or C 1-6 alkyl, and in case that two or more groups R c are inserted into the backbone carbon chain of the linear or branched C 2-30 alkyl group, the two or more groups R c are not directly connected to each other; and wherein each R d is selected from the group consisting of cycloalkylene, arylene, heterocyclylene, heteroarylene, alkynylene, alkenylene, or any combination thereof, wherein the cycloalkylene, arylene, heterocyclylene, and heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C 1-6 alkyl, optionally deuterated C 3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C 1-6 alkoxy, optionally deuterated C 1-6 alkyl-NH-, halogenated C 1-6 alkyl, NH 2 -C 1-6 alkylene, optionally deuterated C 1-6 alkyl-NHC(O)-, optionally deuterated C 1-6 alkyl-C(O)NH-, or any combination thereof; R f represents a bond, -O-, -N(R g )-, -NHC(O)-R h -W 5< -*, -C(O)NH-R h -W 5< -*, -NHC(O)-W 5< -*, - C(O)NH-W 5< -*, -NHC(O)-*, -C(O)NH-*, -O-R h -W 5< -*, -O-W 5< -*, -O-R h -N(R i )-*, -N(R g )-R h -N(R i )-*, - W 5< -, -W 5< -N(R g )-*, -N(R g )-W 5< -*, -N(R g )-W 5< -N(R i )-*, -R h -W 5< -*, -R h -C(O)-W 5< -*, -C(O)-W 5< -*, -R h -C(O)NH-R j -W 5< -*, -R h -NHC(O)-R j -W 5< -*, -R h -C(O)NH-*, -R h -NHC(O)-*, -R h -, -R h -N(R i )-*, or wherein W 5< represents the structure of the following formula: wherein each ring W 6< is the same or different and each independently represents nitrogen-containing heterocyclylene, t1 represents an integer of 1 or 2, and (R a2< ) m2 indicates that each ring W 6< is optionally substituted with m2 R a2< substituents, with each R a2< being independently deuterium, optionally deuterated C 1-6 alkyl, optionally halogenated C 1-6 alkyl, C 1-6 alkoxy, halogen, amino, hydroxy, mercapto, cyano, carboxyl, C 2-6 alkynyl, C 2-6 alkenyl, optionally deuterated C 3-6 cycloalkyl, or R 12a< -R 11a< -, where R 11a< is optionally substituted C 1-6 alkylene or optionally substituted C 2-6 alkenylene, and R 12a< represents halogen, R 13a< R 14a< N-, hydroxy, carboxyl, ethynyl, or vinyl, wherein R 13a< and R 14a< are the same or different and each independently represent hydrogen or C 1-3 alkyl, and m2 represents an integer of 0-20; each ring W 7< is the same or different and each independently represents nitrogen-containing heterocyclylene, arylene, or heteroarylene, t2 represents an integer of 0 or 1, and (R a3< ) m3 indicates that each ring W 7< is independently optionally substituted with m3 R a3< substituents, with each R a3< being independently deuterium, optionally deuterated C 1-6 alkyl, C 1-6 alkoxy, halogen, amino, hydroxy, mercapto, cyano, carboxyl, C 2-6 alkynyl, C 2-6 alkenyl, optionally deuterated C 3-6 cycloalkyl, or R 16a< -R 15a< -, where R 15a< is optionally substituted C 1-6 alkylene or optionally substituted C 2-6 alkenylene, and R 16a< represents halogen, R 17a< R 18a< N-, hydroxy, carboxyl, ethynyl, or vinyl, wherein R 17a< and R 18a< are the same or different and each independently represent hydrogen or C 1-3 alkyl, and m3 represents an integer of 0-20; and R g and R i each independently represent hydrogen or C 1-6 alkyl, R h and R j each independently represent optionally substituted C 1-6 alkylene or optionally substituted C 2-6 alkenylene, and symbol * indicates the point of attachment to LIN; wherein when PBM represents the structure of the following formula: and simultaneously -R f -LIN- represents where symbol ** indicates the point of attachment to ULM, (R b ) n indicates that benzene ring of Formula (ULM) is substituted with 1, 2, or 3 R b , with each R b being the same or different and independently representing deuterium, halogen, hydroxy, mercapto, nitro, amino, cyano, optionally deuterated C 1-6 alkyl, optionally deuterated C 1-6 alkoxy, halogenated C 1-6 alkyl, optionally substituted C 3-6 cycloalkyl, C 2-6 alkenyl, or C 2-6 alkynyl; with the proviso that the following compounds are excluded: 3-(4-((3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1 - yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; N-(5-(3,5-difluorobenzyl)-1H-indazol-3-yl)-4-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperidin-3-yl)piperazin-1-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide; N-(5-(3,5-difluorobenzyl)-1H-indazol-3-yl)-4-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)methyl)piperazin-1-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide; N-(5-(3,5-difluorobenzyl)-1H-indazol-3-yl)-4-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-3-oxoisoindolin-5-yl)methyl)piperidin-3-yl)piperazin-1-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide; N-(5-(3,5-difluorobenzyl)-1H-indazol-3-yl)-4-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-1-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide; N-(5-(3,5-difluorobenzyl)-1H-indazol-3-yl)-4-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)methyl)pyrrolidin-3-yl)piperazin-1-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide; N-(5-(3,5-difluorobenzyl)-1H-indazol-3-yl)-4-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)methyl)piperidin-3-yl)piperazin-1-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide; N-(5-(3,5-difluorobenzyl)-1H-indazol-3-yl)-4-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)methyl)azetidin-3-yl)piperazin-1-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide; 2-(2,6-dioxopiperidin-3-yl)-5-((4-(6-(6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)pyridin-2-yl)piperazin-1-yl)methyl)isoindoline-1,3-dione; and 2-(2,6-dioxopiperidin-3-yl)-5-((3-(4-(6-(6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3 -yl)pyridin-2-yl)piperazin-1-yl)azetidin-1-yl)methyl)isoindoline-1,3 -dione.

[0010] In a further aspect, the present disclosure provides a pharmaceutical composition comprising the compound of Formula (I) or salts, stereoisomers (including enantiomers), solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof, and at least one pharmaceutically acceptable carrier.

[0011] In a further aspect, the present disclosure provides a pharmaceutical composition comprising the compound of Formula (II) or salts, stereoisomers (including enantiomers), solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof, and at least one pharmaceutically acceptable carrier.

[0012] In a further aspect, the present disclosure further provides a medicine kit or reagent kit comprising: the compound of Formula (I) or a pharmaceutically acceptable salt, or the pharmaceutical composition comprising the same; or the compound of Formula (II) or a pharmaceutically acceptable salt, or the pharmaceutical composition comprising the same.

[0013] In a further aspect, the present disclosure provides the compound of Formula (I) or salts, stereoisomers (including enantiomers), solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof, or the pharmaceutical composition comprising the same as active ingredient for use as a medicament.

[0014] In a further aspect, the present disclosure provides the compound of Formula (I) or salts, stereoisomers (including enantiomers), solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof, or the pharmaceutical composition comprising the same as active ingredient for use in the prevention or treatment of cereblon protein-mediated disease or disorder.

[0015] In some embodiments, the cereblon protein-mediated disease or disorder includes, but not limited to, tumor, infectious disease, autoinflammatory disease, inflammatory disease, autoimmune disease, neurological disease, respiratory disease, anemia, hemorrhagic shock, transplant rejection, multiple organ dysfunction syndrome (MODS), sarcoidosis, adult respiratory distress syndrome, cardiovascular disease, Unverricht's syndrome, Richter syndrome (RS), acute liver failure, or diabetes.

[0016] In a further aspect, the present disclosure provides the compound of Formula (II) or salts, stereoisomers (including enantiomers), solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof, or the pharmaceutical composition comprising the same as active ingredient for use as a medicament.

[0017] In a further aspect, the present disclosure provides the compound of Formula (II) or salts, stereoisomers (including enantiomers), solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof, or the pharmaceutical composition comprising the same as active ingredient for use in the treatment and / or prevention of a disease or disorder selected from the group consisting of tumor, infectious disease, autoinflammatory disease, inflammatory disease, autoimmune disease, neurological disease, respiratory disease, anemia, hemorrhagic shock, transplant rejection, multiple organ dysfunction syndrome (MODS), sarcoidosis, adult respiratory distress syndrome, Unverricht's syndrome, Richter syndrome (RS), acute liver failure, diabetes, Kennedy disease, seborrheic alopecia, hirsutism, skin disease, cardiovascular disease, dysfunctional uterine bleeding, anemia, pediatric aplastic anemia, endometriosis, transplant rejection, polycystic ovary syndrome, and thyroid disease.

[0018] In a further aspect, the present disclosure provides use of the compound of Formula (I) or salts, stereoisomers (including enantiomers), solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof for the preparation of the compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof of the present disclosure.

[0019] In a further aspect, the present disclosure also provides a method for preparing the compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof of the present disclosure by using the compound of Formula (I) or salts, stereoisomers (including enantiomers), solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof.

[0020] In a further aspect, the present disclosure provides use of the compound of Formula (I) or salts, stereoisomers (including enantiomers), solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof for the manufacture of a medicament for the prevention or treatment of cereblon protein-mediated disease or disorder.

[0021] In a further aspect, the present disclosure provides use of the compound of Formula (II) or salts, stereoisomers (including enantiomers), solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof for the manufacture of a medicament for the prevention and / or treatment of a disease or disorder selected from the group consisting of tumor, infectious disease, autoinflammatory disease, inflammatory disease, autoimmune disease, neurological disease, respiratory disease, anemia, hemorrhagic shock, transplant rejection, multiple organ dysfunction syndrome (MODS), sarcoidosis, adult respiratory distress syndrome, Unverricht's syndrome, Richter syndrome (RS), acute liver failure, diabetes, Kennedy disease, seborrheic alopecia, hirsutism, skin disease, cardiovascular disease, dysfunctional uterine bleeding, anemia, pediatric aplastic anemia, endometriosis, transplant rejection, polycystic ovary syndrome, and thyroid disease.

[0022] In a further aspect, the present disclosure provides a method for treating or preventing a cereblon protein-mediated disease or disorder in a subject, comprising administering to the subject a therapeutically effective amount of the compound of Formula (I) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof, or the pharmaceutical composition comprising the same.

[0023] In a further aspect, the present disclosure provides a method for treating or preventing a disease or disorder in a subject, comprising administering to the subject a therapeutically effective amount of the compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof, or the pharmaceutical composition comprising the same, wherein the disease or disorder comprises tumor, infectious disease, autoinflammatory disease, inflammatory disease, autoimmune disease, neurological disease, respiratory disease, anemia, hemorrhagic shock, transplant rejection, multiple organ dysfunction syndrome (MODS), sarcoidosis, adult respiratory distress syndrome, Unverricht's syndrome, Richter syndrome (RS), acute liver failure, diabetes, Kennedy disease, seborrheic alopecia, hirsutism, skin disease, cardiovascular disease, dysfunctional uterine bleeding, anemia, pediatric aplastic anemia, endometriosis, transplant rejection, polycystic ovary syndrome, and thyroid disease.Detailed Description of the Invention

[0024] The following detailed description is provided as exemplary specific embodiments to assist those skilled in the art in understanding and practicing the present disclosure. It should be appreciated, however, that such description is not intended to limit the scope of the present disclosure, and that various modifications and changes may be made to the specific embodiments described in the present disclosure without departing from the spirit and scope of the present disclosure. Such changes and modifications are to be understood as being included within the scope of the present invention as defined by the appended claims.I. Compounds Compounds of Formula (I)

[0025] The present disclosure provides a compound of Formula (I) or salts (including pharmaceutically acceptable salts), stereoisomers (including enantiomers), solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof: wherein A, R 1 , R 2 , R 3 , R 4 , (R a ) m , (R b ) n , m and n are s defined in the compounds of Formula (I) above.

[0026] In some embodiments, R 1 , R 2 , R 3 and R 4 of the compound of Formula (I) are the same or different and each independently represent hydrogen, deuterium, halogen (e.g., fluorine, chlorine, bromine, or iodine), optionally deuterated C 1-6 alkyl (e.g., optionally deuterated C 1-4 alkyl, such as methyl, CD 3 , ethyl, propyl, isopropyl, butyl, sec-butyl or tert-butyl), optionally deuterated C 1-6 alkoxy (e.g., optionally deuterated C 1-4 alkoxy, such as methoxy, CD 3 -O-, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), or halogenated C 1-6 alkyl (e.g., halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -).

[0027] In some embodiments, R 1 , R 2 , R 3 and R 4 of the compound of Formula (I) are the same or different and each independently represent hydrogen or deuterium.

[0028] In some embodiments, R 1 , R 2 , R 3 and R 4 of the compound of Formula (I) represent hydrogen.

[0029] In some embodiments, A of the compound of Formula (I) represents CO.

[0030] In some embodiments, A of the compound of Formula (I) represents CH 2 .

[0031] In some embodiments, A of the compound of Formula (I) represents CD 2 .

[0032] In some embodiments, m of the compound of Formula (I) represents an integer of 1, n represents an integer of 0, 1, 2, or 3, and the sum of m and n is an integer of 1, 2, 3, or 4.

[0033] In some embodiments, m of the compound of Formula (I) represents an integer of 2, n represents an integer of 0, 1, or 2, and the sum of m and n is an integer of 2, 3, or 4.

[0034] In some embodiments, when R and R 5 together with the carbon atom to which they are connected form a carbonyl group and R 6 represents hydrogen, m represents an integer of 1, 2, or 3, n represents an integer of 1, 2, or 3, and the sum of m and n is an integer of 2, 3, or 4. In some sub-embodiments, m represents an integer of 1, n represents an integer of 1, 2, or 3, and the sum of m and n is an integer of 2, 3, or 4. In some sub-embodiments, m represents an integer of 2, n represents an integer of 1 or 2, and the sum of m and n is an integer of 3 or 4. In some sub-embodiments, m represents an integer of 3, n represents an integer of 1.

[0035] In some embodiments, R of the compound of Formula (I) represents chlorine, bromine, iodine, hydroxy, leaving group (e.g., -N 3 , chlorine, bromine, iodine, sulfonate, e.g., methanesulfonyloxy (MsO-), trifluoromethanesulfonyloxy (TfO-), or p-toluenesulfonyloxy (TsO-)).

[0036] In some embodiments, R of the compound of Formula (I) represents NR 7 R 8 , wherein R 7 and R 8 are the same or different and each independently represent hydrogen, C 1-6 alkyl (e.g., C 1-4 alkyl or C 1-3 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), C 2-6 alkynyl-C 1-6 alkylene- (e.g., C 2-6 alkynyl-C 1-4 alkylene- or C 2-6 alkynyl-C 1-3 alkylene-, such as ethynyl-methylene-, ethynyl-ethylene-, ethynyl-propylene-, ethynyl-butylene-, ethynyl-pentylene-, or ethynyl-hexylene-), C 2-6 alkenyl-C 1-6 alkylene- (e.g., C 2-6 alkenyl-C 1-4 alkylene- or C 2-6 alkenyl-C 1-3 alkylene-, such as vinyl-methylene-, vinyl-ethylene-, vinyl-propylene-, vinyl-butylene-, vinyl-pentylene-, or vinyl-hexylene-), optionally substituted 4- to 15-membered (e.g., 4- to 11-membered, 4- to 10-membered, 4- to 9-membered, 4- to 8-membered, 4- to 7-membered, 4- to 6-membered, 5- to 15-membered, or 5- to 9-membered) nitrogen-containing monocyclic heterocyclyl, optionally substituted 4- to 15-membered (e.g., 4- to 11-membered, 4- to 10-membered, 4- to 9-membered, 4- to 8-membered, 4- to 7-membered, 4- to 6-membered, 5- to 15-membered, or 5- to 9-membered) nitrogen-containing bridged heterocyclyl, optionally substituted 4- to 15-membered (e.g., 4- to 11-membered, 4- to 10-membered, 4- to 9-membered, 4- to 8-membered, 4- to 7-membered, 4- to 6-membered, 5- to 15-membered, or 5- to 9-membered) nitrogen-containing spiro-heterocyclyl, or R 2a< -R 1a< -, where R 1a< is optionally substituted C 1-6 alkylene (e.g., optionally substituted C 1-4 alkylene, such as optionally substituted methylene, ethylene, or propylene) or optionally substituted C 2-6 alkenylene (e.g., optionally substituted C 2-4 alkenylene, such as optionally substituted vinylene, propenylene, or butenylene), and R 2a< represents halogen (e.g., fluorine, chlorine, bromine, or iodine), amino, hydroxy, carboxyl, CHO, C 2-6 alkynyl (e.g., C 2-4 alkynyl, such as ethynyl, propynyl, or butynyl), C 2-6 alkenyl (e.g., C 2-4 alkenyl, such as vinyl, propenyl, or butenyl) or a leaving group (e.g., -N 3 , chlorine, bromine, iodine, sulfonate, e.g., methanesulfonyloxy (MsO-), trifluoromethanesulfonyloxy (TfO-), or p-toluenesulfonyloxy (TsO-)). The 4- to 15-membered nitrogen-containing monocyclic heterocyclyl, the 4- to 15-membered nitrogen-containing bridged heterocyclyl, and the 4- to 15-membered nitrogen-containing spiro-heterocyclyl are each independently optionally substituted with one or more (e.g., 1-10, such as 1, 2, 3, 4, 5, 6, 8, or 10) substituents selected from the group consisting of deuterium, C 1-6 alkyl (e.g., C 1-4 alkyl or C 1-3 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), C 1-6 alkoxy (e.g., C 1-4 alkoxy, such as methoxy, ethoxy, propoxy, isopropoxy, n-butoxy, isobutoxy, tert-butoxy, pentyloxy, or hexyloxy), halogen (e.g., fluorine, chlorine, bromine, or iodine), leaving group (e.g., -N 3 , chlorine, bromine, iodine, sulfonate, e.g., methanesulfonyloxy (MsO-), trifluoromethanesulfonyloxy (TfO-), or p-toluenesulfonyloxy (TsO-)), amino, hydroxy, carboxyl, CHO, C 2-6 alkynyl (e.g., C 2-4 alkynyl, such as ethynyl, propynyl, or butynyl), C 2-6 alkenyl (e.g., C 2-4 alkenyl, such as vinyl, propenyl, or butenyl), R 4a< -R 3a< -, or any combination thereof, where R 3a< represents optionally substituted C 1-6 alkylene (e.g., optionally substituted C 1-4 alkylene, such as optionally substituted methylene, ethylene, or propylene) or optionally substituted C 2-6 alkenylene (e.g., optionally substituted C 2-4 alkenylene, such as optionally substituted vinylene, propenylene, or butenylene), R 4a< represents halogen, R 5a< R 6a< N-, hydroxy, carboxyl, CHO, ethynyl, vinyl, or leaving group (e.g., -N 3 , chlorine, bromine, iodine, sulfonate, e.g., methanesulfonyloxy (MsO-), trifluoromethanesulfonyloxy (TfO-), or p-toluenesulfonyloxy (TsO-)), wherein R 5a< and R 6a< are the same or different and each independently represent hydrogen or C 1-3 alkyl (e.g., methyl, ethyl, or propyl). The number of substituents is not theoretically limited in any way or automatically limited by the size of the building units. For example, when the substituent is deuterium, the 4- to 15-membered nitrogen-containing monocyclic heterocyclyl, the 4- to 15-membered nitrogen-containing bridged heterocyclyl, and the 4-to 15-membered nitrogen-containing spiro-heterocyclyl are each independently optionally perdeuterated or partially deuterated.

[0037] In some sub-embodiments, R of the compound of Formula (I) represents NR 7 R 8 , wherein R 7 and R 8 are the same or different and each independently represent: hydrogen, C 1-6 alkyl, C 2-6 alkynyl-C 1-6 alkylene-, or C 2-6 alkenyl-C 1-6 alkylene-; or optionally substituted 4- to 15-membered nitrogen-containing monocyclic heterocyclyl, optionally substituted 4- to 15-membered nitrogen-containing bridged heterocyclyl, or optionally substituted 4- to 15-membered nitrogen-containing spiro-heterocyclyl, e.g., piperidinyl, piperazinyl, morpholinyl, azetidinyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, oxazolidinyl, thiazolidinyl, thiomorpholinyl, azepanyl, diazacycloheptanyl, azacyclooctyl, diazacyclooctyl, azabicyclo[3.1.1]heptanyl, azabicyclo[2.2.1]heptanyl, azabicyclo[3.2.1]octanyl, azabicyclo[2.2.2]octanyl, diazabicyclo[3.1.1]heptanyl, diazabicyclo[2.2.1]heptanyl, diazabicyclo[3.2.1]octanyl, diazabicyclo[2.2.2]octanyl, 3-azaspiro[5.5]undecan-3-yl, 8-azaspiro[4.5]decan-4-yl, 2-oxa-8-azaspiro[4.5]decan-4-yl, or 3-methyl-2-oxa-8-azaspiro[4.5]decan-4-yl, or or R 2a< -R 1a< -, wherein R 1a< represents optionally substituted C 1-6 alkylene or optionally substituted C 2-6 alkenylene, and R 2a< represents halogen, amino, hydroxy, carboxyl, CHO, C 2-6 alkynyl, C 2-6 alkenyl, or leaving group, and wherein the 4- to 15-membered nitrogen-containing monocyclic heterocyclyl, 4- to 15-membered nitrogen-containing bridged heterocyclyl and 4- to 15-membered nitrogen-containing spiro-heterocyclyl are each independently optionally substituted with one or more (e.g., 1-10, such as 1, 2, 3, 4, 5, 6, 8, or 10) substituents selected from the group consisting of deuterium, C 1-6 alkyl, C 1-6 alkoxy, halogen, leaving group, amino, hydroxy, carboxyl, CHO, C 2-6 alkynyl, C 2-6 alkenyl, R 4a< -R 3a< -, or any combination thereof, wherein R 3a< represents optionally substituted C 1-6 alkylene or optionally substituted C 2-6 alkenylene, and R 4a< represents halogen, R 5a< R 6a< N-, hydroxy, carboxyl, CHO, ethynyl, vinyl, or leaving group, wherein R 5a< and R 6a< are the same or different and each independently represent hydrogen or C 1-3 alkyl. The number of substituents is not theoretically limited in any way or automatically limited by the size of the building units. For example, when the substituent is deuterium, the 4- to 15-membered nitrogen-containing monocyclic heterocyclyl, the 4- to 15-membered nitrogen-containing bridged heterocyclyl, and the 4- to 15-membered nitrogen-containing spiro-heterocyclyl are each independently optionally perdeuterated or partially deuterated.

[0038] In some embodiments, R of the compound of Formula (I) represents NH 2 , -NHCH 3 , - NHCH 2 CH 3 , -N(CH 3 ) 2 , -N(CH 3 )-CH 2 CH 3 , -N(CH 3 )-CH 2 CH 2 Br, or

[0039] In some embodiments, R of the compound of Formula (I) represents W 1< represented by the structure of the following formula: wherein ring W 2< represents 4- to 20-membered (e.g., 4- to 15-membered, 4- to 12-membered, 4-to 11-membered, 4- to 10-membered, 4- to 9-membered, 4- to 8-membered, 4- to 7-membered, 4- to 6-membered, 5- to 15-membered, or 5- to 9-membered) nitrogen-containing heterocyclyl, e.g., 4- to 20-membered (e.g., 4- to 15-membered, 4- to 12-membered, 4- to 11-membered, 4- to 10-membered, 4- to 9-membered, 4- to 8-membered, 4- to 7-membered, 4- to 6-membered, 5- to 15-membered, or 5- to 9-membered) heterocyclyl containing one nitrogen atom and optionally a heteroatom selected from the group consisting of oxygen, nitrogen, and sulfur, (R a1< ) m1 indicates that ring W 2< is optionally substituted with m1 R a1< substituents, with each R a1< being independently deuterium, optionally deuterated C 1-6 alkyl (e.g., optionally deuterated C 1-4 alkyl, such as methyl, CD 3 , ethyl, propyl, isopropyl, butyl, sec-butyl, or tert-butyl), C 1-6 alkoxy (e.g., C 1-4 alkoxy, such as methoxy, CD 3 -O-, ethoxy, propoxy, isopropoxy, n-butoxy, isobutoxy, or tert-butoxy), halogen (e.g., fluorine, chlorine, bromine, or iodine), leaving group (e.g., -N 3 , chlorine, bromine, iodine, sulfonate, e.g., methanesulfonyloxy (MsO-), trifluoromethanesulfonyloxy (TfO-) or p-toluenesulfonyloxy (TsO-)), amino, hydroxy, mercapto, cyano, carboxyl, CHO, C 2-6 alkynyl (e.g., C 2-4 alkynyl, such as ethynyl, propynyl, or butynyl), C 2-6 alkenyl (e.g., C 2-4 alkenyl, such as vinyl, propenyl, or butenyl), optionally deuterated C 3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl, or optionally perdeuterated cyclohexyl), or R 8a< -R 7a< -, wherein R 7a< is optionally substituted C 1-6 alkylene (e.g., optionally substituted C 1-4 alkylene, such as optionally substituted methylene, ethylene or propylene) or optionally substituted C 2-6 alkenylene (e.g., optionally substituted C 2-4 alkenylene, such as optionally substituted vinylene, propenylene, butenylene); and R 8a< represents halogen (e.g., fluorine, chlorine, bromine, or iodine), R 9a< R 10a< N-, hydroxy, carboxyl, CHO, ethynyl, vinyl, or leaving group (e.g., -N 3 , chlorine, bromine, iodine, sulfonate, e.g., methanesulfonyloxy (MsO-), trifluoromethanesulfonyloxy (TfO-) or p-toluenesulfonyloxy (TsO-)), wherein R 9a< and R 10a< are the same or different and each independently represent hydrogen or C 1-3 alkyl (e.g., methyl, ethyl, or propyl); wherein m1 represents an integer of 0-20 (e.g., an integer of 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or 20). The number of substituents is not theoretically limited in any way or automatically limited by the size of the building units.

[0040] In some sub-embodiments, R of the compound of Formula (I) represents W 1< represented by the structure of the following formula: wherein ring W 2< represents 4- to 20-membered nitrogen-containing heterocyclyl, e.g., 4- to 20-membered (e.g., 4- to 15-membered, 4- to 12-membered, 4- to 11-membered, 4- to 10-membered, 4- to 9-membered, 4- to 8-membered, 4- to 7-membered, 4- to 6-membered, 5- to 15-membered, or 5- to 9-membered) heterocyclyl containing one nitrogen atom and optionally a heteroatom selected from the group consisting of oxygen, nitrogen, and sulfur, e.g., piperidinyl, piperazinyl, morpholinyl, azetidinyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, oxazolidinyl, thiazolidinyl, thiomorpholinyl, azepanyl, diazacycloheptanyl, azacyclooctyl, diazacyclooctyl, azabicyclo[3.1. 1]heptanyl, azabicyclo[2.2.1]heptanyl, azabicyclo[3.2.1]octanyl, azabicyclo[2.2.2]octanyl, diazabicyclo[3.1.1]heptanyl, diazabicyclo[2.2.1]heptanyl, diazabicyclo[3.2.1]octanyl, diazabicyclo[2.2.2]octanyl, 3-azaspiro[5.5]undecan-3-yl, 8-azaspiro[4.5]decan-4-yl, 2-oxa-8-azaspiro[4.5]decan-4-yl, or 3-methyl-2-oxa-8-azaspiro[4.5]decan-4-yl, or (R a1< ) m1 indicates that ring W 2< is optionally substituted with m1 R a1< substituents, with each R a1< being independently deuterium, optionally deuterated C 1-6 alkyl, C 1-6 alkoxy, halogen, leaving group, amino, hydroxy, mercapto, cyano, carboxyl, CHO, C 2-6 alkynyl, C 2-6 alkenyl, optionally deuterated C 3-6 cycloalkyl, or R 8a< -R 7a< -, wherein R 7a< is optionally substituted C 1-6 alkylene or optionally substituted C 2-6 alkenylene, and R 8a< represents halogen, R 9a< R 10a< N-, hydroxy, carboxyl, CHO, ethynyl, vinyl, or leaving group, wherein R 9a< and R 10a< are the same or different and each independently represent hydrogen or C 1-3 alkyl; wherein m1 represents an integer of 0-20 (e.g., an integer of 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or 20). The number of substituents is not theoretically limited in any way or automatically limited by the size of the building units.

[0041] In some embodiments, ring W 2< is optionally perdeuterated or partially deuterated.

[0042] In some embodiments, R of the compound of Formula (I) represents W 1< represented by the structure of the following formula: wherein each ring W 3< is the same or different and each independently represents 4- to 20-membered (e.g., 4- to 15-membered, 4- to 12-membered, 4- to 11-membered, 4- to 10-membered, 4- to 9-membered, 4- to 8-membered, 4- to 7-membered, 4- to 6-membered, 5- to 15-membered, or 5- to 9-membered) nitrogen-containing heterocyclylene, e.g., 4- to 20-membered (e.g., 4- to 15-membered, 4-to 12-membered, 4- to 11-membered, 4- to 10-membered, 4- to 9-membered, 4- to 8-membered, 4- to 7-membered, 4- to 6-membered, 5- to 15-membered, or 5- to 9-membered) heterocyclylene containing one nitrogen atom and optionally a heteroatom selected from the group consisting of oxygen, nitrogen, and sulfur; t represents an integer of 1 or 2, and (R a2< ) m2 indicates that each ring W 3< is optionally substituted with m2 R a2< substituents, with each R a2< being independently deuterium, optionally deuterated C 1-6 alkyl (e.g., optionally deuterated C 1-4 alkyl, such as methyl, CD 3 , ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), C 1-6 alkoxy (e.g., C 1-4 alkoxy, such as methoxy, ethoxy, propoxy, isopropoxy, n-butoxy, sec-butoxy, tert-butoxy, pentyloxy, or hexyloxy), halogen (e.g., fluorine, chlorine, bromine, or iodine), leaving group (e.g., -N 3 , chlorine, bromine, iodine, sulfonate, e.g., methanesulfonyloxy (MsO-), trifluoromethanesulfonyloxy (TfO-) or p-toluenesulfonyloxy (TsO-)), amino, hydroxy, mercapto, cyano, carboxyl, CHO, C 2-6 alkynyl (e.g., C 2-4 alkynyl, such as ethynyl, propynyl, or butynyl), C 2-6 alkenyl (e.g., C 2-4 alkenyl, such as vinyl, propenyl, or butenyl), optionally deuterated C 3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl, or optionally perdeuterated cyclohexyl), or R 12a< -R 11a< -, wherein R 11a< is optionally substituted C 1-6 alkylene (e.g., optionally substituted C 1-4 alkylene, such as optionally substituted methylene, ethylene or propylene) or optionally substituted C 2-6 alkenylene (e.g., optionally substituted C 2-4 alkenylene, such as optionally substituted methylene, ethylene or propylene), and R 12a< represents halogen (e.g., fluorine, chlorine, bromine, or iodine), R 13a< R 14a< N-, hydroxy, carboxyl, CHO, ethynyl, vinyl, or leaving group (e.g., -N 3 , chlorine, bromine, iodine, sulfonate, e.g., methanesulfonyloxy (MsO-), trifluoromethanesulfonyloxy (TfO-), or p-toluenesulfonyloxy (TsO-)), wherein R 13a< and R 14a< are the same or different and each independently represent hydrogen or C 1-3 alkyl (e.g., methyl, ethyl, or propyl); and ring W 4< represents 4- to 15-membered (e.g., 4- to 12-membered, 4- to 11-membered, 4- to 10-membered, 4- to 9-membered, 4- to 8-membered, 4- to 7-membered, 4- to 6-membered, 5- to 15-membered, or 5- to 9-membered) nitrogen-containing heterocyclyl (e.g., 4- to 15-membered (e.g., 4- to 15-membered, 4- to 12-membered, 4- to 11-membered, 4- to 10-membered, 4- to 9-membered, 4- to 8-membered, 4- to 7-membered, 4- to 6-membered, 5- to 15-membered, or 5- to 9-membered) heterocyclyl containing one nitrogen atom and optionally a heteroatom selected from the group consisting of oxygen, nitrogen, and sulfur), 6- to 10-membered aryl, or 5- to 10-membered (e.g., 5- to 6-membered, or 5- to 9-membered) heteroaryl (e.g., 5- to 10-membered (e.g., 5- to 9-membered, 5- to 8-membered, 5- to 7-membered, or 5- to 6-membered) heteroaryl containing one nitrogen atom and optionally a heteroatom selected from the group consisting of oxygen, nitrogen, and sulfur); (R a3< ) m3 indicates that ring W 4< is optionally substituted with m3 R a3< substituents, with each R a3< independently representing deuterium, optionally deuterated C 1-6 alkyl (e.g., optionally deuterated C 1-4 alkyl, such as methyl, CD 3 , ethyl, propyl, isopropyl, butyl, sec-butyl, or tert-butyl), C 1-6 alkoxy (e.g., C 1-4 alkoxy, such as methoxy, ethoxy, propoxy, isopropoxy, n-butoxy, sec-butoxy, tert-butoxy, pentyloxy, or hexyloxy), halogen (e.g., fluorine, chlorine, bromine, or iodine), leaving group (e.g., -N 3 , chlorine, bromine, iodine, sulfonate, e.g., methanesulfonyloxy (MsO-), trifluoromethanesulfonyloxy (TfO-) or p-toluenesulfonyloxy (TsO-)), amino, hydroxy, mercapto, cyano, carboxyl, CHO, C 2-6 alkynyl (e.g., C 2-4 alkynyl, such as ethynyl, propynyl, or butynyl), C 2-6 alkenyl (e.g., C 2-4 alkenyl, such as vinyl, propenyl, or butenyl), optionally deuterated C 3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl, or optionally perdeuterated cyclohexyl), or R 16a< -R 15a< -, wherein R 15a< is optionally substituted C 1-6 alkylene (e.g., optionally substituted C 1-4 alkylene, such as optionally substituted methylene, ethylene or propylene) or optionally substituted C 2-6 alkenylene (e.g., optionally substituted C 2-4 alkenylene, such as optionally substituted vinylene, propenylene, butenylene), and R 16a< represents halogen (e.g., fluorine, chlorine, bromine, or iodine), R 17a< R 18a< N-, hydroxy, carboxyl, CHO, ethynyl, vinyl, or leaving group (e.g., -N 3 , chlorine, bromine, iodine, sulfonate, e.g., methanesulfonyloxy (MsO-), trifluoromethanesulfonyloxy (TfO-) or p-toluenesulfonyloxy (TsO-)), wherein R 17a< and R 18a< are the same or different and each independently represent hydrogen or C 1-3 alkyl (e.g., methyl, ethyl, or propyl); wherein m2 and m3 each independently represent an integer of 0-20 (e.g., an integer of 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or 20). The number of substituents is not theoretically limited in any way or automatically limited by the size of the building units.

[0043] In some sub-embodiments, R of the compound of Formula (I) represents W 1< represented by the structure of the following formula: wherein each ring W 3< is the same or different and each independently represents 4- to 20-membered nitrogen-containing heterocyclylene, e.g., piperidinylene, piperazinylene, morpholinylene, azetidinylene, pyrrolidinylene, imidazolidylene, pyrazolidylene, oxazolidinylene, thiazolidinylene, thiomorpholinylene, azepanylene, diazacycloheptanylene, azacyclooctylene, diazacyclooctylene, azabicyclo[3.1.1]heptanylene, azabicyclo[2.2.1]heptanylene, azabicyclo[3.2.1]octanylene, azabicyclo[2.2.2]octanylene, diazabicyclo[3.1.1]heptanylene, diazabicyclo[2.2.1]heptanylene, diazabicyclo[3.2.1]octanylene, diazabicyclo[2.2.2]octanylene, 3-azaspiro[5.5]undecan-3-ylene, 8-azaspiro[4.5]decan-4-ylene, 2-oxa-8-azaspiro[4.5]decan-4-ylene, or 3-methyl-2-oxa-8-azaspiro[4.5]decan-4-ylene, or t represents an integer of 1 or 2, and (R a2< ) m2 indicates that each ring W 3< is optionally substituted with m2 R a2< substituents, with each R a2< being independently deuterium, optionally deuterated C 1-6 alkyl, C 1-6 alkoxy, halogen, leaving group, amino, hydroxy, mercapto, cyano, carboxyl, CHO, C 2-6 alkynyl, C 2-6 alkenyl, optionally deuterated C 3-6 cycloalkyl, or R 12a< -R 11a< -, wherein R 11a< is optionally substituted C 1-6 alkylene or optionally substituted C 2-6 alkenylene, and R 12a< represents halogen, R 13a< R 14a< N-, hydroxy, carboxyl, CHO, ethynyl, vinyl, or leaving group, wherein R 13a< and R 14a< are the same or different and each independently represent hydrogen or C 1-3 alkyl; and ring W 4< represents 4- to 15-membered nitrogen-containing heterocyclyl, 6- to 10-membered aryl, or 5- to 10-membered heteroaryl, e.g., piperidinyl, piperazinyl, morpholinyl, azetidinyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, oxazolidinyl, thiazolidinyl, thiomorpholinyl, azepanyl, diazacycloheptanyl, azacyclooctyl, diazacyclooctyl, azabicyclo[3.1.1]heptanyl, azabicyclo[2.2.1]heptanyl, azabicyclo[3.2.1]octanyl, azabicyclo[2.2.2]octanyl, diazabicyclo[3.1.1]heptanyl, diazabicyclo[2.2.1]heptanyl, diazabicyclo[3.2.1]octanyl, diazabicyclo[2.2.2]octanyl, 3-azaspiro[5.5]undecan-3-yl, 8-azaspiro[4.5]decan-4-yl, 2-oxa-8-azaspiro[4.5]decan-4-yl, 3-methyl-2-oxa-8-azaspiro[4.5]decan-4-yl, phenyl, naphthyl, furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzotriazolyl, benzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphthyridinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, pyrrolo[2,1-b]thiazolyl, or imidazo[2,1-b]thiazolyl; or (R a3< ) m3 indicates that ring W 4< is optionally substituted with m3 R a3< substituents, with each R a3< independently representing deuterium, optionally deuterated C 1-6 alkyl, C 1-6 alkoxy, halogen, leaving group, amino, hydroxy, mercapto, cyano, carboxyl, CHO, C 2-6 alkynyl, C 2-6 alkenyl, optionally deuterated C 3-6 cycloalkyl, or R 16a< -R 15a< -, wherein R 15a< is optionally substituted C 1-6 alkylene or optionally substituted C 2-6 alkenylene, and R 16a< represents halogen, R 17a< R 18a< N-, hydroxy, carboxyl, CHO, ethynyl, vinyl, or leaving group, wherein R 17a< and R 18a< are the same or different and each independently represent hydrogen or C 1-3 alkyl; wherein m2 and m3 each independently represent an integer of 0-20 (e.g., an integer of 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or 20). The number of substituents is not theoretically limited in any way or automatically limited by the size of the building units.

[0044] In some sub-embodiments, each ring W 3< is independently optionally perdeuterated or partially deuterated.

[0045] In some sub-embodiments, ring W 4< is optionally perdeuterated or partially deuterated.

[0046] In some sub-embodiments, R of the compound of Formula (I) represents the following groups: chlorine, bromine, iodine, hydroxy, -N 3 , sulfonate, e.g., methanesulfonyloxy (MsO-), trifluoromethanesulfonyloxy (TfO-) or p-toluenesulfonyloxy (TsO-), NH 2 , or or

[0047] In some embodiments, R 5 and R 6 of the compound of Formula (I) each independently represent: hydrogen, fluorine, chlorine, bromine, iodine, optionally substituted methyl, or optionally substituted linear or branched C 2-30 alkyl, wherein one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, 1-2, or 1) groups R c and / or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, 1-2, or 1) groups R d and / or any combination of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, 1-2, or 1) groups R c and R d are optionally inserted into the backbone carbon chain of the linear or branched C 2-30 alkyl group, wherein carbon-carbon bond between one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, 1-2, or 1) pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R c , R d , or a combination of R c and R d ; wherein each R c is selected from the group consisting of O, N(R e ), C(O), C(O)O, S(O), S(O) 2 , S(O) 2 NH, NHS(O) 2 , OC(O), C(O)N(R e ), N(R e )C(O), or N(R e )C(O)N(R e ), where each R e independently represents H or C 1-6 alkyl (e.g., C 1-4 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), and in case that two or more groups R c are inserted into the backbone carbon chain of the linear or branched C 2-30 alkyl group, the two or more groups R c are not directly connected to each other; and wherein each R d is selected from the group consisting of cycloalkylene (e.g., C 3-20 cycloalkylene), arylene (e.g., C 3-20 arylene), heterocyclylene (e.g., 4- to 20-membered heterocyclylene), heteroarylene (e.g., 4- to 20-membered heteroarylene), alkynylene (e.g., C 2-6 alkynylene), alkenylene (e.g., C 2-6 alkenylene), or any combination thereof, wherein the cycloalkylene, arylene, heterocyclylene, and heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C 1-6 alkyl (e.g., optionally deuterated C 1-4 alkyl, such as methyl, CD 3 , ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), optionally deuterated C 3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl, or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, halogen (e.g., fluorine, chlorine, bromine, or iodine), optionally deuterated C 1-6 alkoxy (e.g., optionally deuterated C 1-4 alkoxy, such as methoxy, CD 3 -O-, ethoxy, propoxy, isopropoxy, n-butoxy, sec-butoxy, or tert-butoxy), optionally deuterated C 1-6 alkyl-NH- (e.g., optionally deuterated C 1-3 alkyl-NH-, such as CH 3 NH-, CH 3 CH 2 NH- or CH 3 CH 2 CH 2 NH-), halogenated C 1-6 alkyl (e.g., halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), NH 2 -C 1-6 alkylene (e.g., NH 2 -C 1-3 alkylene-, such as NH 2 CH 2 -, NH 2 CH 2 CH 2 - and NH 2 CH 2 CH 2 CH 2 -), optionally deuterated C 1-6 alkyl-NHC(O)- (e.g., optionally deuterated C 1-4 alkyl-NHC(O)-, such as CH 3 -NHC(O)-, CH 3 CH 2 -NHC(O)-, and CH 3 CH 2 CH 2 -NHC(O)-), optionally deuterated C 1-6 alkyl-C(O)NH-(e.g., optionally deuterated C 1-4 alkyl-C(O)NH-, such as CH 3 -C(O)NH-, CH 3 CH 2 -C(O)NH-, and CH 3 CH 2 CH 2 -C(O)NH-), cyano or any combination thereof; and a hydrogen atom of methyl and hydrogen atom of one or more (e.g., 1-30, such as 1-25, 1-20, 1-15, 1-10, 1-5, 1-4, 1-3, 1-2 or 1) CH 2 of C 2-30 alkyl are optionally substituted with a substituent selected from the group consisting of deuterium, hydroxy, amino, mercapto, nitro, halogen (e.g., fluorine, chlorine, bromine, or iodine), cyano, optionally deuterated C 1-6 alkyl (e.g., optionally deuterated C 1-4 alkyl, such as methyl, CD 3 , ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 alkyl (e.g., halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), optionally deuterated C 3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl, or optionally perdeuterated cyclohexyl), optionally deuterated C 1-6 alkoxy (e.g., optionally deuterated C 1-4 alkoxy, such as methoxy, CD 3 -O-, ethoxy, propoxy, isopropoxy, n-butoxy, sec-butoxy, or tert-butoxy), optionally deuterated C 1-6 alkyl-NH- (e.g., optionally deuterated C 1-3 alkyl-NH-, such as CH 3 NH-, CH 3 CH 2 NH- or CH 3 CH 2 CH 2 NH-), NH 2 -C 1-6 alkylene (e.g., NH 2 -C 1-3 alkylene-, such as NH 2 CH 2 -, NH 2 CH 2 CH 2 - and NH 2 CH 2 CH 2 CH 2 -), optionally deuterated C 1-6 alkyl-NHC(O)- (e.g., optionally deuterated C 1-4 alkyl-NHC(O)-, such as CH 3 -NHC(O)-, CH 3 CH 2 -NHC(O)-, and CH 3 CH 2 CH 2 -NHC(O)-), optionally deuterated C 1-6 alkyl-C(O)NH- (e.g., optionally deuterated C 1-4 alkyl-C(O)NH-, such as CH 3 -C(O)NH-, CH 3 CH 2 -C(O)NH-, and CH 3 CH 2 CH 2 -C(O)NH-), or any combination thereof.

[0048] In some embodiments, R 5 of the compound of Formula (I) represents hydrogen, fluorine, chlorine, bromine, iodine, optionally substituted methyl, optionally substituted methoxy, optionally substituted ethoxy, optionally substituted propoxy, optionally substituted butoxy, or optionally substituted tert-butoxy.

[0049] In some embodiments, R and R 5 together with the carbon atom to which they are connected of the compound of Formula (I) form carbonyl group. In other words, R a of the compound of Formula (I) represents the following group: wherein R 6 is as defined above.

[0050] In some embodiments, R and R 5 are as defined in the compound of Formula (I) above and any one of its embodiments, and R 6 represents: hydrogen, fluorine, chlorine, bromine, iodine, optionally substituted methyl, or optionally substituted linear or branched C 2-30 alkyl, wherein one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, 1-2, or 1) groups R c and / or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, 1-2, or 1) groups R d and / or any combination of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, 1-2, or 1) groups R c and R d are optionally inserted into the backbone carbon chain of the linear or branched C 2-30 alkyl group, wherein carbon-carbon bond between one or more (e.g., 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, 1-2, or 1) pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R c , R d , or a combination of R c and R d ; wherein each R c is selected from the group consisting of O, N(R e ), C(O), C(O)O, S(O), S(O) 2 , S(O) 2 NH, NHS(O) 2 , OC(O), C(O)N(R e ), N(R e )C(O), or N(R e )C(O)N(R e ), where each R e independently represents H or C 1-6 alkyl (e.g., C 1-4 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), and in case that two or more groups R c are inserted into the backbone carbon chain of the linear or branched C 2-30 alkyl group, the two or more groups R c are not directly connected to each other; and wherein each R d is selected from the group consisting of cycloalkylene (e.g., C 3-20 cycloalkylene), arylene (e.g., C 3-20 arylene), heterocyclylene (e.g., 4- to 20-membered heterocyclylene), heteroarylene (e.g., 4- to 20-membered heteroarylene), alkynylene (e.g., C 2-6 alkynylene), alkenylene (e.g., C 2-6 alkenylene), or any combination thereof, wherein the cycloalkylene, arylene, heterocyclylene, and heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C 1-6 alkyl (e.g., optionally deuterated C 1-4 alkyl, such as methyl, CD 3 , ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), optionally deuterated C 3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl, or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, halogen (e.g., fluorine, chlorine, bromine, or iodine), optionally deuterated C 1-6 alkoxy (e.g., optionally deuterated C 1-4 alkoxy, such as methoxy, CD 3 -O-, ethoxy, propoxy, isopropoxy, n-butoxy, sec-butoxy, or tert-butoxy), optionally deuterated C 1-6 alkyl-NH- (e.g., optionally deuterated C 1-3 alkyl-NH-, such as CH 3 NH-, CH 3 CH 2 NH- or CH 3 CH 2 CH 2 NH-), halogenated C 1-6 alkyl (e.g., halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), NH 2 -C 1-6 alkylene (e.g., NH 2 -C 1-3 alkylene-, such as NH 2 CH 2 -, NH 2 CH 2 CH 2 - and NH 2 CH 2 CH 2 CH 2 -), optionally deuterated C 1-6 alkyl-NHC(O)- (e.g., optionally deuterated C 1-4 alkyl-NHC(O)-, such as CH 3 -NHC(O)-, CH 3 CH 2 -NHC(O)-, and CH 3 CH 2 CH 2 -NHC(O)-), optionally deuterated C 1-6 alkyl-C(O)NH-(e.g., optionally deuterated C 1-4 alkyl-C(O)NH-, such as CH 3 -C(O)NH-, CH 3 CH 2 -C(O)NH-, and CH 3 CH 2 CH 2 -C(O)NH-), cyano or any combination thereof; and a hydrogen atom of methyl and hydrogen atom of one or more (e.g., 1-30, such as 1-25, 1-20, 1-15, 1-10, 1-5, 1-4, 1-3, 1-2 or 1) CH 2 of C 2-30 alkyl are optionally substituted with a substituent selected from the group consisting of deuterium, hydroxy, amino, mercapto, nitro, halogen (e.g., fluorine, chlorine, bromine, or iodine), cyano, optionally deuterated C 1-6 alkyl (e.g., optionally deuterated C 1-4 alkyl, such as methyl, CD 3 , ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 alkyl (e.g., halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), optionally deuterated C 3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl, or optionally perdeuterated cyclohexyl), optionally deuterated C 1-6 alkoxy (e.g., optionally deuterated C 1-4 alkoxy, such as methoxy, CD 3 -O-, ethoxy, propoxy, isopropoxy, n-butoxy, sec-butoxy, or tert-butoxy), optionally deuterated C 1-6 alkyl-NH- (e.g., optionally deuterated C 1-3 alkyl-NH-, such as CH 3 NH-, CH 3 CH 2 NH- or CH 3 CH 2 CH 2 NH-), NH 2 -C 1-6 alkylene (e.g., NH 2 -C 1-3 alkylene-, such as NH 2 CH 2 -, NH 2 CH 2 CH 2 - and NH 2 CH 2 CH 2 CH 2 -), optionally deuterated C 1-6 alkyl-NHC(O)- (e.g., optionally deuterated C 1-4 alkyl-NHC(O)-, such as CH 3 -NHC(O)-, CH 3 CH 2 -NHC(O)-, and CH 3 CH 2 CH 2 -NHC(O)-), optionally deuterated C 1-6 alkyl-C(O)NH- (e.g., optionally deuterated C 1-4 alkyl-C(O)NH-, such as CH 3 -C(O)NH-, CH 3 CH 2 -C(O)NH-, and CH 3 CH 2 CH 2 -C(O)NH-), or any combination thereof.

[0051] In some sub-embodiments, R 6 of the compound of Formula (I) represents hydrogen, fluorine, chlorine, bromine, or iodine.

[0052] In some sub-embodiments, R 6 of the compound of Formula (I) represents the structure of the following formula: -C 1-30 alkyl; -(C(R a4< )(R a5< )) n1 -(R c -(C(R a6< )(R a7< )) n2 ) m4 -H; -(C(R a4< )(R a5< )) n1 -(R c -(C(R a6< )(R a7< )) n2 ) m4 -(R c -(C(R a8< )(R a9< )) n3 ) m5 -H; -(C(R a4< )(R a5< )) n1 -(R c -(C(R a6< )(R a7< )) n2 ) m4 -(R c -(C(R a8< )(R a9< )) n3 ) m5 -(R c -(C(R a10< )(R a11< )) n4 ) m6 -H; -(C(R a4< )(R a5< )) n1 -(R d -(C(R a6< )(R a7< )) n2 ) m4 -H; -(C(R a4< )(R a5< )) n1 -(R d -(C(R a6< )(R a7< )) n2 ) m4 -(R d -(C(R a8< )(R a9< )) n3 ) m5 -H; -(C(R a4< )(R a5< )) n1 -(R d -(C(R a6< )(R a7< )) n2 ) m4 -(R d -(C(R a8< )(R a9< )) n3 ) m5 -(R d -(C(R a10< )(R a11< )) n4 ) m6 -H; -(C(R a4< )(R a5< )) n1 -(R c -R d -(C(R a6< )(R a7< )) n2 ) m4 -H; -(C(R a4< )(R a5< )) n1 -(R c -(C(R a6< )(R a7< )) n2 ) m4 -(R d -(C(R a8< )(R a9< )) n3 ) m5 -H; -(C(R a4< )(R a5< )) n1 -(R d -R c -(C(R a6< )(R a7< )) n2 ) m4 -H; or -(C(R a4< )(R a5< )) n1 -(R d -(C(R a6< )(R a7< )) n2 ) m4 -(R c -(C(R a8< )(R a9< )) n3 ) m5 -H; wherein each R c is selected from the group consisting of O, N(R e ), C(O), C(O)O, OC(O), S(O), S(O) 2 , S(O) 2 NH, NHS(O) 2 , C(O)N(R e ), N(R e )C(O), or N(R e )C(O)N(R e ), where each R e independently represents H or C 1-6 alkyl; and wherein each R d is selected from the group consisting of cycloalkylene (e.g., C 3-20 cycloalkylene), arylene (e.g., C 5-20 arylene), heterocyclylene (e.g., 4- to 20-membered heterocyclylene), heteroarylene (e.g., 5- to 20-membered heteroarylene), alkynylene (e.g., C 2-6 alkynylene), alkenylene (e.g., C 2-6 alkenylene), or any combination thereof, wherein the cycloalkylene, arylene, heterocyclylene, and heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, (e.g., optionally deuterated C 1-4 alkyl, such as methyl, CD 3 , ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), optionally deuterated C 3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl, or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, halogen (e.g., fluorine, chlorine, bromine, or iodine), optionally deuterated C 1-6 alkoxy (e.g., optionally deuterated C 1-4 alkoxy, such as methoxy, CD 3 -O-, ethoxy, propoxy, isopropoxy, n-butoxy, sec-butoxy, or tert-butoxy), optionally deuterated C 1-6 alkyl-NH- (e.g., optionally deuterated C 1-3 alkyl-NH-, such as CH 3 NH-, CH 3 CH 2 NH- or CH 3 CH 2 CH 2 NH-), halogenated C 1-6 alkyl (e.g., halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), NH 2 -C 1-6 alkylene (e.g., NH 2 -C 1-3 alkylene-, such as NH 2 CH 2 -, NH 2 CH 2 CH 2 - and NH 2 CH 2 CH 2 CH 2 -), optionally deuterated C 1-6 alkyl-NHC(O)- (e.g., optionally deuterated C 1-4 alkyl-NHC(O)-, such as CH 3 -NHC(O)-, CH 3 CH 2 -NHC(O)-, and CH 3 CH 2 CH 2 -NHC(O)-), optionally deuterated C 1-6 alkyl-C(O)NH- (e.g., optionally deuterated C 1-4 alkyl-C(O)NH-, such as CH 3 -C(O)NH-, CH 3 CH 2 -C(O)NH-, and CH 3 CH 2 CH 2 -C(O)NH-), cyano, or any combination thereof; a hydrogen atom of one or more (e.g., 1-30, such as 1-25, 1-20, 1-15, 1-10, 1-5, 1-4, 1-3, 1-2 or 1) CH 2 of C 1-30 alkyl are optionally substituted with a substituent selected from the group consisting of deuterium, hydroxy, amino, mercapto, nitro, halogen (e.g., fluorine, chlorine, bromine, or iodine), cyano, optionally deuterated C 1-6 alkyl (e.g., optionally deuterated C 1-4 alkyl, such as methyl, CD 3 , ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 alkyl (e.g., halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), optionally deuterated C 3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl, or optionally perdeuterated cyclohexyl), optionally deuterated C 1-6 alkoxy (e.g., optionally deuterated C 1-4 alkoxy, such as methoxy, CD 3 -O-, ethoxy, propoxy, isopropoxy, n-butoxy, sec-butoxy, or tert-butoxy), optionally deuterated C 1-6 alkyl-NH- (e.g., optionally deuterated C 1-3 alkyl-NH-, such as CH 3 NH-, CH 3 CH 2 NH- or CH 3 CH 2 CH 2 NH-), NH 2 -C 1-6 alkylene (e.g., NH 2 -C 1-3 alkylene-, such as NH 2 CH 2 -, NH 2 CH 2 CH 2 - and NH 2 CH 2 CH 2 CH 2 -), optionally deuterated C 1-6 alkyl-NHC(O)- (e.g., optionally deuterated C 1-4 alkyl-NHC(O)-, such as CH 3 -NHC(O)-, CH 3 CH 2 -NHC(O)-, and CH 3 CH 2 CH 2 -NHC(O)-), optionally deuterated C 1-6 alkyl-C(O)NH- (e.g., optionally deuterated C 1-4 alkyl-C(O)NH-, such as CH 3 -C(O)NH-, CH 3 CH 2 -C(O)NH-, and CH 3 CH 2 CH 2 -C(O)NH-), or any combination thereof; R a4< , R a5< , R a6< , R a7< , R a8< , R a9< , R a10< and R a11< each independently represent H, deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C 1-6 alkyl (e.g., optionally deuterated C 1-4 alkyl, such as methyl, CD 3 , ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 alkyl (e.g., halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), optionally deuterated C 3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl, or optionally perdeuterated cyclohexyl), optionally deuterated C 1-6 alkoxy (e.g., optionally deuterated C 1-4 alkoxy, such as methoxy, CD 3 -O-, ethoxy, propoxy, isopropoxy, n-butoxy, sec-butoxy, or tert-butoxy), optionally deuterated C 1-6 alkyl-NH- (e.g., optionally deuterated C 1-3 alkyl-NH-, such as CH 3 NH-, CH 3 CH 2 NH- or CH 3 CH 2 CH 2 NH-), NH 2 -C 1-6 alkylene (e.g., NH 2 -C 1-3 alkylene-, such as NH 2 CH 2 -, NH 2 CH 2 CH 2 - and NH 2 CH 2 CH 2 CH 2 -), optionally deuterated C 1-6 alkyl-NHC(O)- (e.g., optionally deuterated C 1-4 alkyl-NHC(O)-, such as CH 3 -NHC(O)-, CH 3 CH 2 -NHC(O)-, and CH 3 CH 2 CH 2 -NHC(O)-), or optionally deuterated C 1-6 alkyl-C(O)NH- (e.g., optionally deuterated C 1-4 alkyl-C(O)NH-, such as CH 3 -C(O)NH-, CH 3 CH 2 -C(O)NH-, and CH 3 CH 2 CH 2 -C(O)NH-); and n1, n2, n3, n4, m4, m5, and m6 each independently represent an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

[0053] In some sub-embodiments, R 6 of the compound of Formula (I) represents the structure of the following formula: -(C(R a4< )(R a5< )) n1 -(O-(C(R a6< )(R a7< )) n2 ) m4 -H; -(C(R a4< )(R a5< )) n1 -(O-(C(R a6< )(R a7< )) n2 ) m4 -(O-(C(R a8< )(R a9< )) n3 ) m5 -H; -(C(R a4< )(Ra 5< )) n1 -(O-(C(R a6< )(R a7< )) n2 ) m4 -(O-(C(R a8< )(R a9< )) n3 ) m5 -(O-(C(R al0< )(R al< l)) n4 ) m6 -H; -(C(Ra 4< )(R a5< )) ni -(N(Re)-(C(Ra 6< )(Ra 7< )) n2 ) m4 -H; -(C(R a4< )(R a5< )) n1 -(N(R e )-(C(R a6< )(R a7< )) n2 ) m4 -(N(R e )-(C(R a8< )(R a9< )) n3 ) m5< -H; -(C(R a4< )(R a5< )) n1 -(N(R e )-(C(R a6< )(R a7< )) n2 ) m4 -(N(R e )-(C(R a8< )(R a9< )) n3 ) m5 -(N(R e )-(C(R a10< )(R a11< )) n4 ) m6 -H; -(C(R a4< )(R a5< )) n1 -(C(O)N(R e )-(C(R a6< )(R a7< )) n2 ) m4 -H; -(C(R a4< )(R a5< )) n1 -(C(O)N(R e )-(C(R a6< )(R a7< )) n2 ) m4 -(C(O)N(R e )-(C(R a8< )(R a9< )) n3 ) m5 -H; -(C(R a4< )(R a5< )) n1 -(C(O)N(R e )-(C(R a6< )(R a7< )) n2 ) m4 -(C(O)N(R e )-(C(R a8< )(R a9< )) n3 ) m5 -(C(O)N(R e )-(C(R a10< )(R a11< )) n4 ) m6 -H; -(C(R a4< )(R a5< )) n1 -(C(O)N(R e )-(C(R a6< )(R a7< )) n2 ) m4 -(O-(C(R a8< )(R a9< )) n3 ) m5 -H; -(C(R a4< )(R a5< )) n1 -C(O)N(R e )-(C(R a6< )(R a7< )) n2 -(O-(C(R a8< )(R a9< )) n3 ) m4 -H; -(C(R a4< )(R a5< )) n1 -(N(R e )C(O)-(C(R a6< )(R a7< )) n2 ) m4 -H; -(C(R a4< )(R a5< )) n1 -(N(R e )C(O)-(C(R a6< )(R a7< )) n2 ) m4 -(O-(C(R a8< )(R a9< )) n3 ) m5 -H; -(C(R a4< )(R a5< )) n1 -(N(R e )C(O)-(C(R a6< )(R a7< )) n2 ) m4 -(O-(C(R a8< )(R a9< )) n3 ) m5 -(O-(C(R a10< )(R a11< )) n4 ) m6 -H; -(C(R a4< )(R a5< )) n1 -N(R e )C(O)-(C(R a6< )(R a7< )) n2 -(O-(C(R a8< )(R a9< )) n3 ) m4 -H; -(C(R a4< )(R a5< )) n1 -N(R e )C(O)N(R e )-(C(R a6< )(R a7< )) n2 -H; -(C(R a4< )(R a5< )) n1 -C(O)-(C(R a6< )(R a7< )) n2 -H; -(C(R a< 4)arylene-(C(R a6< )(R a< 7)-H; -(C(R a< 4)arylene-(C(R a6< )(R a7< )-arylene-(C(R a8< )(R a9< )H; -(C(R a4< )(R a5< )) n1 -(heterocyclylene-(C(R a6< )(R a7< )) n2 ) m4 -H; -(C(R a4< )(R a5< )) n1 -(heterocyclylene-(C(R a6< )(R a7< )) n2 ) m4 -(heterocyclylene-(C(R a8< )(R a9< )) n3 ) m5 -H; -(C(R a4< )(R a5< )) n1 -(heteroarylene-(C(R a6< )(R a7< )) n2 ) m4 -H; -(C(R a4< )(R as< )) n1 -(heteroarylene-(C(R a6< )(R a7< )) n2 ) m4 -(heteroarylene-(C(R a8< )(R a9< )) n3 ) m5 -H; -(C(R a4< )(R a5< )) n1 -(cycloalkylene-(C(R a6< )(R a7< )) n2 ) m4 -H;or -(C(R a4< )(R a5< )) n1 -(cycloalkylene-(C(R a6< )(R a7< )) n2 ) m4 -(cycloalkylene-(C(R a8< )(R a9< )) n3 ) m5 -H; wherein each R e independently represents H or C 1-6 alkyl (e.g., C 1-4 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl); the cycloalkylene (e.g., C 3-20 cycloalkylene, C 3-15 cycloalkylene, C 3-10 cycloalkylene, C 3-8 cycloalkylene, or C 3-6 cycloalkylene), arylene (e.g., C 5-20 arylene, C 5-15 arylene, C 5-10 arylene, or C 5-6 arylene), heterocyclylene (e.g., 4- to 20-membered heterocyclylene, 4- to 15-membered heterocyclylene, 4- to 10-membered heterocyclylene, 4- to 9-membered heterocyclylene, 4- to 8-membered heterocyclylene, 5- to 7-membered heterocyclylene, or 6-membered heterocyclylene) and heteroarylene (e.g., 5- to 20-membered heteroarylene, 5- to 15-membered heteroarylene, 5- to 10-membered heteroarylene, 5- to 9-membered heteroarylene, 5- to 8-membered heteroarylene, 5- to 7-membered heteroarylene, or 6-membered heteroarylene,) are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C 1-6 alkyl (e.g., optionally deuterated C 1-4 alkyl, such as methyl, CD 3 , ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), optionally deuterated C 3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl, or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, halogen (e.g., fluorine, chlorine, bromine, or iodine), optionally deuterated C 1-6 alkoxy (e.g., optionally deuterated C 1-4 alkoxy, such as methoxy, CD 3 -O-, ethoxy, propoxy, isopropoxy, n-butoxy, sec-butoxy, or tert-butoxy), optionally deuterated C 1-6 alkyl-NH- (e.g., optionally deuterated C 1-3 alkyl-NH-, such as CH 3 NH-, CH 3 CH 2 NH- or CH 3 CH 2 CH 2 NH-), halogenated C 1-6 alkyl (e.g., halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), NH 2 -C 1-6 alkylene (e.g., NH 2 -C 1-3 alkylene-, such as NH 2 CH 2 -, NH 2 CH 2 CH 2 - and NH 2 CH 2 CH 2 CH 2 -), optionally deuterated C 1-6 alkyl-NHC(O)- (e.g., optionally deuterated C 1-4 alkyl-NHC(O)-, such as CH 3 -NHC(O)-, CH 3 CH 2 -NHC(O)-, and CH 3 CH 2 CH 2 -NHC(O)-), optionally deuterated C 1-6 alkyl-C(O)NH- (e.g., optionally deuterated C 1-4 alkyl-C(O)NH-, such as CH 3 -C(O)NH-, CH 3 CH 2 -C(O)NH-, and CH 3 CH 2 CH 2 -C(O)NH-), cyano, or any combination thereof; R a4< , R a5< , R a6< , R a7< , R a8< , R a9< , R a10< and R a11< each independently represent H, deuterium, hydroxy, amino, mercapto, nitro, halogen (e.g., fluorine, chlorine, bromine, or iodine), cyano, optionally deuterated C 1-6 alkyl (e.g., optionally deuterated C 1-4 alkyl, such as methyl, CD 3 , ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 alkyl (e.g., halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), optionally deuterated C 3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl, or optionally perdeuterated cyclohexyl), optionally deuterated C 1-6 alkoxy (e.g., optionally deuterated C 1-4 alkoxy, such as methoxy, CD 3 -O-, ethoxy, propoxy, isopropoxy, n-butoxy, sec-butoxy, or tert-butoxy), optionally deuterated C 1-6 alkyl-NH- (e.g., optionally deuterated C 1-3 alkyl-NH-, such as CH 3 NH-, CH 3 CH 2 NH- or CH 3 CH 2 CH 2 NH-), NH 2 -C 1-6 alkylene (e.g., NH 2 -C 1-3 alkylene-, such as NH 2 CH 2 -, NH 2 CH 2 CH 2 - and NH 2 CH 2 CH 2 CH 2 -), optionally deuterated C 1-6 alkyl-NHC(O)- (e.g., optionally deuterated C 1-4 alkyl-NHC(O)-, such as CH 3 -NHC(O)-, CH 3 CH 2 -NHC(O)-, and CH 3 CH 2 CH 2 -NHC(O)-), or optionally deuterated C 1-6 alkyl-C(O)NH- (e.g., optionally deuterated C 1-4 alkyl-C(O)NH-, such as CH 3 -C(O)NH-, CH 3 CH 2 -C(O)NH-, and CH 3 CH 2 CH 2 -C(O)NH-); and n1, n2, n3, n4, m4, m5, and m6 each independently represent an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

[0054] In some sub-embodiments, R 6 of the compound of Formula (I) represents the following groups: H, fluorine, chlorine, bromine, iodine, -CH 3 , -CH 2 -CH 3 , -(CH 2 ) 2 -CH 3 , -(CH 2 ) 3 -CH 3 , -(CH 2 ) 4 -CH 3 , -(CH 2 ) 5 -CH 3 , -(CH 2 ) 6 -CH 3 , -(CH 2 ) 7 -CH 3 , -(CH 2 ) 8 -CH 3 , -(CH 2 ) 9 -CH 3 , -(CH 2 ) 1O -CH 3 , -(CH 2 ) 11 -CH 3 , - (CH 2 ) 12 -CH 3 , -(CH 2 ) 13 -CH 3 , -(CH 2 ) 14 -CH 3 , -(CH 2 ) 15 -CH 3 , -(CH 2 ) 16 -CH 3 , -(CH 2 ) 17 -CH 3 , -(CH 2 ) 18 -CH 3 , -(CH 2 ) 19 -CH 3 , -(CH 2 ) 20 -CH 3 , -(CH 2 ) 21 -CH 3 , -(CH 2 ) 22 -CH 3 , -(CH 2 ) 25 -CH 3 , -(CH 2 ) 29 -CH 3 ;-CH 2 -O-CH 3 , -CH 2 -O-CH 2 -CH 3 , -CH 2 -O-(CH 2 ) 2 -CH 3 , -(CH 2 ) 1 -O-(CH 2 ) 3 -CH 3 , -(CH 2 ) 1 -O-(CH 2 ) 4 -CH 3 , -(CH 2 ) 1 -O-(CH 2 ) 5 -CH 3 , -(CH 2 ) 1 -O-(CH 2 ) 6 -CH 3 , -(CH 2 ) 1 -O-(CH 2 ) 7 -CH 3 , -(CH 2 ) 1 -O-(CH 2 ) 8 -CH 3 , -(CH 2 ) 1 -O-(CH 2 ) 9 -CH 3 , -(CH 2 ) 1 -O-(CH 2 ) 10 -CH 3 , -(CH 2 ) 2 -O-CH 3 , -(CH 2 ) 2 -O-CH 2 -CH 3 , -(CH 2 ) 2 -O-(CH 2 ) 2 -CH 3 , - (CH 2 ) 2 -O-(CH 2 ) 3 -CH 3 , -(CH 2 ) 2 -O-(CH 2 ) 4 -CH 3 , -(CH 2 ) 2 -O-(CH 2 ) 5 -CH 3 , -(CH 2 ) 2 -O-(CH 2 ) 6 -CH 3 , - (CH 2 ) 2 -O-(CH 2 ) 7 -CH 3 , -(CH 2 ) 2 -O-(CH 2 ) 8 -CH 3 , -(CH 2 ) 2 -O-(CH 2 ) 9 -CH 3 , -(CH 2 ) 2 -O-(CH 2 ) I0 -CH 3 , - (CH 2 ) 2 -O-(CH 2 ) 11 -CH 3 , -(CH 2 ) 2 -O-(CH 2 ) 12 -CH 3 , -(CH 2 ) 3 -O-CH 3 , -(CH 2 ) 3 -O-CH 2 -CH 3 , -(CH 2 ) 3 -O-(CH 2 ) 2 -CH 3 , -(CH 2 ) 3 -O-(CH 2 ) 3 -CH 3 , -(CH 2 ) 3 -O-(CH 2 ) 4 -CH 3 , -(CH 2 ) 3 -O-(CH 2 ) 5 -CH 3 , -(CH 2 ) 3 -O-(CH 2 ) 6 -CH 3 , -(CH 2 ) 3 -O-(CH 2 ) 7 -CH 3 , -(CH 2 ) 4 -O-CH 3 , -(CH 2 ) 4 -O-CH 2 -CH 3 , -(CH 2 ) 4 -O-(CH 2 ) 2 -CH 3 , - (CH 2 ) 4 -O-(CH 2 ) 3 -CH 3 , -(CH 2 ) 4 -O-(CH 2 ) 4 -CH 3 , -(CH 2 ) 4 -O-(CH 2 ) 5 -CH 3 , -(CH 2 ) 4 -O-(CH 2 ) 6 -CH 3 , - (CH 2 ) 5 -O-CH 3 , -(CH 2 ) 5 -O-CH 2 -CH 3 , -(CH 2 ) 5 -O(CH 2 ) 2 -CH 3 , -(CH 2 ) 5 -O-(CH 2 ) 3 -CH 3 , -(CH 2 ) 5 -O-(CH 2 ) 4 -CH 3 , -(CH 2 ) 5 -O-(CH 2 ) 5 -CH 3 , -(CH 2 ) 6 -O-CH 3 , -(CH 2 ) 6 -O-CH 2 -CH 3 , -(CH 2 ) 6 -O-(CH 2 ) 2 -CH 3 , - (CH 2 ) 6 -O-(CH 2 ) 3 -CH 3 , -(CH 2 ) 6 -O-(CH 2 ) 4 -CH 3 , -(CH 2 ) 7 -O-CH 3 , -(CH 2 ) 7 -O-CH 2 -CH 3 , -(CH 2 ) 7 -O-(CH 2 ) 2 -CH 3 , -(CH 2 ) 7 -O-(CH 2 ) 3 -CH 3 , -(CH 2 ) 8 -O-CH 3 , -(CH 2 ) 8 -O-CH 2 -CH 3 , -(CH 2 ) 8 -O-(CH 2 ) 2 -CH 3 , - CH(CH 3 )-O-CH 3 , -CH(CH 3 )-O-CH 2 -CH 3 , -CH(CH 3 )-O-(CH 2 ) 2 -CH 3 , -CH(CH 3 )-O-(CH 2 ) 3 -CH 3 , - CH(CH 3 )-O-(CH 2 ) 4 -CH 3 , -CH(CH 3 )-O-(CH 2 ) 5 -CH 3 , -CH(CH 3 )-O-(CH 2 ) 6 -CH 3 , -CH(CH 3 )-O-(CH 2 ) 7 -CH 3 , -CH(CH 3 )-O-(CH 2 ) 8 -CH 3 , -CH(CH 3 )-O-(CH 2 ) 9 -CH 3 , -CH(CH 3 )-O-(CH 2 ) 10 -CH 3 , -CH 2 -(O(CH 2 ) 2 ) 1 -OCH 2 CH 3 , -CH 2 -(O(CH 2 ) 2 ) 2 -OCH 2 CH 3 , -CH 2 -(O(CH 2 ) 2 ) 3 -OCH 2 CH 3 , -CH 2 -(O(CH 2 ) 2 ) 4 -OCH 2 CH 3 , -CH 2 -(O(CH 2 ) 2 ) 5 -OCH 2 CH 3 , -CH 2 -(O(CH 2 ) 2 ) 6 -OCH 2 CH 3 , -CH 2 -(O(CH 2 ) 2 ) 7 -OCH 2 CH 3 , - CH 2 -(O(CH 2 ) 2 ) 8 -OCH 2 CH 3 , -CH 2 -(O(CH 2 ) 2 ) 9 -OCH 2 CH 3 , -CH 2 -(O(CH 2 ) 2 ) 10 -OCH 2 CH 3 , -CH 2 -(O(CH 2 ) 2 ) 1 -OCH 3 , -CH 2 -(O(CH 2 ) 2 ) 2 -OCH 3 , -CH 2 -(O(CH 2 ) 2 ) 3 -OCH 3 , -CH 2 -(O(CH 2 ) 2 ) 4 -OCH 3 , -CH 2 -(O(CH 2 ) 2 ) 5 -OCH 3 , -CH 2 -(O(CH 2 ) 2 ) 6 -OCH 3 , -CH 2 -(O(CH 2 ) 2 ) 7 -OCH 3 , -CH 2 -(O(CH 2 ) 2 ) 8 -OCH 3 , -CH 2 -(O(CH 2 ) 2 ) 9 -OCH 3 , -CH 2 -(O(CH 2 ) 2 ) 10 -OCH 3 , -(CH 2 ) 2 -(O(CH 2 ) 2 ) 1 -OCH 2 CH 3 , -(CH 2 ) 2 -(O(CH 2 ) 2 ) 2 -OCH 2 CH 3 , -(CH 2 ) 2 -(O(CH 2 ) 2 ) 3 -OCH 2 CH 3 , -(CH 2 ) 2 -(O(CH 2 ) 2 ) 4 -OCH 2 CH 3 , -(CH 2 ) 2 -(O(CH 2 ) 2 ) 5 -OCH 2 CH 3 , -(CH 2 ) 2 -(O(CH 2 ) 2 ) 6 -OCH 2 CH 3 , -(CH 2 ) 2 -(O(CH 2 ) 2 ) 7 -OCH 2 CH 3 , -(CH 2 ) 2 -(O(CH 2 ) 2 ) 8 -OCH 2 CH 3 , -(CH 2 ) 2 -(O(CH 2 ) 2 ) 9 -OCH 2 CH 3 , -(CH 2 ) 2 -(O(CH 2 ) 2 ) 10 -OCH 2 CH 3 , -(CH 2 ) 3 -(O(CH 2 ) 2 ) 1 -OCH 2 CH 3 , -(CH 2 ) 3 -(O(CH 2 ) 2 ) 2 -OCH 2 CH 3 , -(CH 2 ) 3 -(O(CH 2 ) 2 ) 3 -OCH 2 CH 3 , -(CH 2 ) 3 -(O(CH 2 ) 2 ) 4 -OCH 2 CH 3 , -(CH 2 ) 3 -(O(CH 2 ) 2 ) 5 -OCH 2 CH 3 , -(CH 2 ) 3 -(O(CH 2 ) 2 ) 6 -OCH 2 CH 3 , -(CH 2 ) 3 -(O(CH 2 ) 2 ) 7 -OCH 2 CH 3 , -(CH 2 ) 3 -(O(CH 2 ) 2 ) 8 -OCH 2 CH 3 , -(CH 2 ) 3 -(O(CH 2 ) 2 ) 9 -OCH 2 CH 3 , -(CH 2 ) 3 -(O(CH 2 ) 2 ) 10 -OCH 2 CH 3 , -(CH 2 ) 4 -(O(CH 2 ) 2 ) 1 -OCH 2 CH 3 , -(CH 2 ) 4 -(O(CH 2 ) 2 ) 2 -OCH 2 CH 3 , -(CH 2 ) 4 -(O(CH 2 ) 2 ) 3 -OCH 2 CH 3 , -(CH 2 ) 4 -(O(CH 2 ) 2 ) 4 -OCH 2 CH 3 , -(CH 2 ) 4 -(O(CH 2 ) 2 ) 5 -OCH 2 CH 3 , -(CH 2 ) 4 -(O(CH 2 ) 2 ) 6 -OCH 2 CH 3 , -(CH 2 ) 4 -(O(CH 2 ) 2 ) 7 -OCH 2 CH 3 , -(CH 2 ) 4 -(O(CH 2 ) 2 ) 8 -OCH 2 CH 3 , -(CH 2 ) 4 -(O(CH 2 ) 2 ) 9 -OCH 2 CH 3 , -(CH 2 ) 4 -(0(CH 2 ) 2 ) lO -OCH 2 CH 3 , -CH 2 -(O(CH 2 ) 3 ) 1 -OCH 2 CH 2 CH 3 , -CH 2 -(O(CH 2 ) 3 ) 2 -OCH 2 CH 2 CH 3 , -CH 2 -(O(CH 2 ) 3 ) 3 -OCH 2 CH 2 CH 3 , -CH 2 -(O(CH 2 ) 3 ) 4 -OCH 2 CH 2 CH 3 , -CH 2 -(O(CH 2 ) 3 ) 5 -OCH 2 CH 2 CH 3 , -CH 2 -(O(CH 2 ) 3 ) 6 -OCH 2 CH 2 CH 3 , -CH 2 -(O(CH 2 ) 3 ) 7 -OCH 2 CH 2 CH 3 , -CH 2 -(O(CH 2 ) 3 ) 8 -OCH 2 CH 2 CH 3 , -CH 2 -(O(CH 2 ) 3 ) 9 -OCH 2 CH 2 CH 3 , -CH 2 -(O(CH 2 ) 3 ) l o-OCH 2 CH 2 CH 3 , -(CH 2 ) 2 -(O(CH 2 ) 3 ) t -OCH 2 CH 2 CH 3 , -(CH 2 ) 2 -(O(CH 2 ) 3 ) 2 -OCH 2 CH 2 CH 3 , -(CH 2 ) 2 -(O(CH 2 ) 3 ) 3 -OCH 2 CH 2 CH 3 , - (CH 2 ) 2 -(O(CH 2 ) 3 ) 4 -OCH 2 CH 2 CH 3 , -(CH 2 ) 2 -(O(CH 2 ) 3 ) 5 -OCH 2 CH 2 CH 3 , -(CH 2 ) 2 -(O(CH 2 ) 3 ) 6 -OCH 2 CH 2 CH 3 , -(CH 2 ) 2 -(O(CH 2 ) 3 ) 7 -OCH 2 CH 2 CH 3 , -(CH 2 ) 2 -(O(CH 2 ) 3 ) S -OCH 2 CH 2 CH 3 , -(CH 2 ) 3 -(O(CH 2 ) 3 ) t -OCH 2 CH 2 CH 3 , -(CH 2 ) 3 -(O(CH 2 ) 3 ) 2 -OCH 2 CH 2 CH 3 , -(CH 2 ) 3 -(O(CH 2 ) 3 ) 3 -OCH 2 CH 2 CH 3 , - (CH 2 ) 3 -(O(CH 2 ) 3 ) 4 -OCH 2 CH 2 CH 3 , -(CH 2 ) 3 -(O(CH 2 ) 3 ) 5 -OCH 2 CH 2 CH 3 , -(CH 2 ) 3 -(O(CH 2 ) 3 ) 6 -OCH 2 CH 2 CH 3 , -(CH 2 ) 3 -(O(CH 2 ) 3 ) 7 -OCH 2 CH 2 CH 3 , -(CH 2 ) 3 -(O(CH 2 ) 3 ) 8 -OCH 2 CH 2 CH 3 , -CH 2 -O-(CH 2 ) 2 -O-(CH 2 ) 2 -CH 3 , -CH 2 -(O(CH 2 ) 2 ) 2 -(O(CH 2 ) 3 ) 1 -OCH 2 CH 2 CH 3 , -CH 2 -(O(CH 2 ) 2 ) 3 -(O(CH 2 ) 3 ) 2 -OCH 2 CH 2 CH 3 , -CH 2 -(O(CH 2 ) 2 ) 4 -(O(CH 2 ) 3 ) 3 -OCH 2 CH 2 CH 3 , -CH 2 -(O(CH 2 ) 2 ) 5 -(O(CH 2 ) 3 ) 4 -OCH 2 CH 2 CH 3 , -(CH 2 ) 2 -O-(CH 2 ) 2 -O-(CH 2 ) 2 CH 3 , -(CH 2 ) 2 -(O(CH 2 ) 2 ) 2 -(O(CH 2 ) 3 ) 1 -OCH 2 CH 2 CH 3 , - (CH 2 ) 2 -(O(CH 2 ) 2 ) 3 -(O(CH 2 ) 3 ) 2 -OCH 2 CH 2 CH 3 , -(CH 2 ) 2 -(O(CH 2 ) 2 ) 4 -(O(CH 2 ) 3 ) 3 -OCH 2 CH 2 CH 3 , - (CH 2 ) 2 -(O(CH 2 ) 2 ) 5 -(O(CH 2 ) 3 ) 4 -OCH 2 CH 2 CH 3 , -(CH 2 ) 3 -O-(CH 2 ) 2 -O-(CH 2 ) 2 CH 3 , -(CH 2 ) 3 -(O(CH 2 ) 2 ) 2 -(O(CH 2 ) 3 ) t -OCH 2 CH 2 CH 3 , -(CH 2 ) 3 -(O(CH 2 ) 2 ) 3 -(O(CH 2 ) 3 ) 2 -OCH 2 CH 2 CH 3 , -(CH 2 ) 3 -(O(CH 2 ) 2 ) 4 -(O(CH 2 ) 3 ) 3 -OCH 2 CH 2 CH 3 , -(CH 2 ) 3 -(O(CH 2 ) 2 ) 5 -(O(CH 2 ) 3 ) 4 -OCH 2 CH 2 CH 3 , -CH 2 -O-(CH 2 ) 3 -O-CH 2 CH 3 , -CH 2 -(O(CH 2 ) 3 ) 2 -(O(CH 2 ) 2 ) I -O-CH 2 CH 3 , -CH 2 -(O(CH 2 ) 3 ) 3 -(O(CH 2 ) 2 ) 2 -O-CH 2 CH 3 , -CH 2 -(O(CH 2 ) 3 ) 4 -(O(CH 2 ) 2 ) 3 -O-CH 2 CH 3 , -CH 2 -(O(CH 2 ) 3 ) 5 -(O(CH 2 ) 2 ) 4 -O-CH 2 CH 3 , -(CH 2 ) 2 -O-(CH 2 ) 3 -O-CH 2 CH 3 , -(CH 2 ) 2 -(O(CH 2 ) 3 ) 2 -(O(CH 2 ) 2 ) 1 -O-CH 2 CH 3 , -(CH 2 ) 2 -(O(CH 2 ) 3 ) 3 -(O(CH 2 ) 2 ) 2 -O-CH 2 CH 3 , - (CH 2 ) 2 -(O(CH 2 ) 3 ) 4 -(O(CH 2 ) 2 ) 3 -O-CH 2 CH 3 , -(CH 2 ) 2 -(O(CH 2 ) 3 ) 5 -(O(CH 2 ) 2 ) 4 -O-CH 2 CH 3 , -(CH 2 ) 3 -O-(CH 2 ) 3 -O-CH 2 CH 3 , -(CH 2 ) 3 -(O(CH 2 ) 3 ) 2 -(O(CH 2 ) 2 ) 1 -O-CH 2 CH 3 , -(CH 2 ) 3 -(O(CH 2 ) 3 ) 3 -(O(CH 2 ) 2 ) 2 -O-CH 2 CH 3 , -(CH 2 ) 3 -(O(CH 2 ) 3 ) 4 -(O(CH 2 ) 2 ) 3 -O-CH 2 CH 3 , -(CH 2 ) 3 -(O(CH 2 ) 3 ) 5 -(O(CH 2 ) 2 ) 4 -O-CH 2 CH 3 , - CH 2 -O-(CH 2 ) 2 -O-CH 3 , -(CH 2 ) 2 -O-(CH 2 ) 2 -O-CH 3 , -(CH 2 ) 2 -(O(CH 2 ) 2 ) 2 -O-(CH 2 ) 2 CH 3 , -(CH 2 ) 2 -(O(CH 2 ) 2 ) 3 -O-(CH 2 ) 2 CH 3 , -(CH 2 ) 2 -(O(CH 2 ) 2 ) 4 -O-(CH 2 ) 2 CH 3 , -(CH 2 ) 5 -(O(CH 2 ) 2 ) 2 -O-(CH 2 ) 4 CH 3 , - (CH 2 ) 5 -(O(CH 2 ) 2 ) 2 -O-(CH 2 ) 5 CH 3 , -(CH 2 ) 1 -N(R e )-CH 3 , -(CH 2 ) 1 -N(R e )-(CH 2 ) 1 -CH 3 , -(CH 2 ) 1 -N(R e )-(CH 2 ) 2 -CH 3 , -(CH 2 ) 1 -N(R e )-(CH 2 ) 3 -CH 3 , -(CH 2 ) 1 -N(R e )-(CH 2 ) 4 -CH 3 , -(CH 2 ) 1 -N(Re)-(CH 2 ) 5 -CH 3 , - (CH 2 ) 1 -N(R e )-(CH 2 ) 6 -CH 3 , -(CH 2 ) 1 -N(R e )-(CH2) 7 -CH 3 , -(CH 2 ) 1 -N(R e )-(CH 2 ) 8 -CH 3 , -(CH 2 ) 1 -N(R e )-(CH 2 ) 9 -CH 3 , -(CH 2 ) 2 -N(R e )-CH 3 , -(CH 2 ) 2 -N(R e )-(CH 2 ) 1 -CH 3 , -(CH 2 ) 2 -N(R e )-(CH 2 ) 2 -CH 3 , -(CH 2 ) 2 -N(R e )-(CH 2 ) 3 -CH 3 , -(CH 2 ) 2 -N(R e )-(CH 2 ) 4 -CH 3 , -(CH 2 ) 2 -N(R e )-(CH 2 ) 5 -CH 3 , -(CH 2 ) 2 -N(R e )-(CH 2 ) 6 -CH 3 , -(CH 2 ) 2 -N(R e )-(CH 2 ) 7 -CH 3 , -(CH 2 ) 2 -N(R e )-(CH 2 ) 8 -CH 3 , -(CH 2 ) 2 -N(R e )-(CH 2 ) 9 -CH 3 , -(CH 2 ) 2 -N(R e )-(CH 2 ) 10 -CH 3 , -(CH 2 ) 2 -N(R e )-(CH 2 ) 11 -CH 3 , -(CH 2 ) 3 -N(R e )-CH 3 , -(CH 2 ) 3 -N(R e )-(CH 2 ) 1 -CH 3 , - (CH 2 ) 3 -N(R e )-(CH 2 ) 2 -CH 3 , -(CH 2 ) 4 -N(R e )-CH 3 , -(CH 2 ) 4 -N(R e )-(CH 2 ) 1 -CH 3 , -(CH 2 ) 4 -N(R e )-(CH 2 ) 2 -CH 3 , -(CH 2 ) 4 -N(R e )-(CH 2 ) 3 -CH 3 , -(CH 2 ) 5 -N(R e )-CH 3 , -(CH 2 ) 5 -N(R e )-(CH 2 ) 1 -CH 3 , -(CH 2 ) 5 -N(R e )-(CH 2 ) 2 -CH 3 , -(CH 2 ) 5 -N(R e )-(CH 2 ) 3 -CH 3 , -(CH 2 ) 5 -N(R e )-(CH 2 ) 4 -CH 3 , -(CH 2 ) 6 -N(R e )-CH 3 , -(CH 2 ) 6 -N(R e )-(CH 2 ) 1 -CH 3 , -(CH 2 ) 6 -N(R e )-(CH 2 ) 2 -CH 3 , -(CH 2 ) 7 -N(R e )-CH 3 , -(CH 2 ) 7 -N(R e )-(CH 2 ) 1 -CH 3 , - (CH 2 ) 7 -N(R e )-(CH 2 ) 2 -CH 3 , -(CH 2 ) 8 -N(R e )-CH 3 , -(CH 2 ) 8 -N(R e )-(CH 2 ) 1 -CH 3 , -(CH 2 ) 8 -N(R e )-(CH 2 ) 2 -CH 3 , -CH(CH 3 )-N(R e )-CH 3 , -CH(CH 3 )-N(R e )-(CH 2 ) 1 -CH 3 , -CH(CH 3 )-N(R e )-(CH 2 ) 2 -CH 3 , -CH(CH 3 )-N(R e )-(CH 2 ) 3 -CH 3 , -CH(CH 3 )-N(R e )-(CH 2 ) 4 -CH 3 , -CH(CH 3 )-N(R e )-(CH 2 ) 5 -CH 3 , -CH(CH 3 )-N(R e )-(CH 2 ) 6 -CH 3 , -CH(CH 3 )-N(R e )-(CH 2 ) 7 -CH 3 , -CH(CH 3 )-N(R e )-(CH 2 ) 8 -CH 3 , -CH(CH 3 )-N(R e )-(CH 2 ) 9 -CH 3 , -CH 2 C(O)NHCH 3 , -(CH 2 ) 2 C(O)NHCH 2 CH 3 , -(CH 2 ) 2 C(O)NH(CH 2 ) 2 -CH 3 , - (CH 2 ) 2 C(O)NH(CH 2 ) 3 -CH 3 , -(CH 2 ) 2 C(O)NH(CH 2 ) 4 -CH 3 , -(CH 2 ) 3 C(O)NH(CH 2 ) 2 -CH 3 , - (CH 2 ) 3 C(O)NH(CH 2 ) 3 -CH 3 , -(CH 2 ) 4 C(O)NH(CH 2 ) 3 -CH 3 , -(CH 2 ) 5 C(O)NH(CH 2 ) 4 -CH 3 , - (CH 2 ) 6 C(O)NH(CH 2 ) 6 -CH 3 , -(CH 2 ) 6 C(O)NH(CH 2 ) 5 -CH 3 , -(CH 2 ) 7 C(O)NH(CH 2 ) 6 -CH 3 , - (CH 2 ) 8 C(O)NH(CH 2 ) 7 -CH 3 , U-(CH 2 ) 9 C(O)NH(CH 2 ) 8 -CH 3 , -(CH 2 ) 10 C(O)NH(CH 2 ) 9 -CH 3 , - (CH 2 ) 2 C(O)NH(CH 2 ) 2 -O-CH 2 -CH 3 , -CH 2 NHC(O)CH 3 , -(CH 2 ) 2 NHC(O)CH 2 CH 3 , - (CH 2 ) 2 NHC(O)(CH 2 ) 2 -CH 3 , -(CH 2 ) 2 NHC(O)(CH 2 ) 3 -CH 3 , -(CH 2 ) 2 NHC(O)(CH 2 ) 4 -CH 3 , - (CH 2 ) 3 NHC(O)(CH 2 ) 2 -CH 3 , -(CH 2 ) 3 NHC(O)(CH 2 ) 3 -CH 3 , -(CH 2 ) 4 NHC(O)(CH 2 ) 3 -CH 3 , - (CH 2 ) 5 NHC(O)(CH 2 ) 4 -CH 3 , -(CH 2 ) 6 NHC(O)(CH 2 ) 6 -CH 3 , -(CH 2 ) 6 NHC(O)(CH 2 ) 5 -CH 3 , - (CH 2 ) 7 NHC(O)(CH 2 ) 6 -CH 3 , -(CH 2 ) 8 NHC(O)(CH 2 ) 7 -CH 3 , -(CH 2 ) 9 NHC(O)(CH 2 ) 8 -CH 3 , - (CH 2 ) 10 NHC(O)(CH 2 ) 9 -CH 3 , -(CH 2 ) 4 NHC(O)(CH 2 ) 7 -CH 3 , -(CH 2 ) 2 NHC(O)(CH 2 ) 2 -O-CH 2 -CH 3 , - (CH 2 ) 4 NHC(O)CH 3 , -CH 2 -pipendinylene-CH 3 , -CH 2 -piperidinylene-CH 2 -CH 3 , -CH 2 -piperidinylene-(CH 2 ) 2 -CH 3 , -CH 2 -piperidinylene-(CH 2 ) 3 -CH 3 , -CH 2 -piperidinylene-(CH 2 ) 4 -CH 3 , -CH 2 -piperidinylene-(CH 2 ) 5 -CH 3 , -CH 2 -piperidinylene-(CH 2 ) 6 -CH 3 , -CH 2 -piperidinylene-(CH 2 ) 7 -CH 3 , - (CH 2 ) 2 -piperidinylene-CH 3 , -(CH 2 ) 2 -piperidinylene-CH 2 -CH 3 , -(CH 2 ) 2 -piperidinylene-(CH 2 ) 2 -CH 3 , - (CH 2 ) 2 -piperidinylene-(CH 2 ) 3 -CH 3 , -(CH 2 ) 2 -piperidinylene-(CH 2 ) 4 -CH 3 , -(CH 2 ) 2 -piperidinylene-(CH 2 ) 5 -CH 3 , -(CH 2 ) 2 -piperidinylene-(CH 2 ) 6 -CH 3 , -(CH 2 ) 2 -piperidinylene-(CH 2 ) 7 -CH 3 , -(CH 2 ) 3 -piperidinylene-CH 3 , -(CH 2 ) 3 -piperidinylene-CH 2 -CH 3 , -(CH 2 ) 3 -piperidinylene-(CH 2 ) 2 -CH 3 , -(CH 2 ) 3 -piperidinylene-(CH 2 ) 3 -CH 3 , -(CH 2 ) 3 -piperidinylene-(CH 2 ) 4 -CH 3 , -(CH 2 ) 3 -piperidinylene-(CH 2 ) 5 -CH 3 , -(CH 2 ) 3 -piperidinylene-(CH 2 ) 6 -CH 3 , -(CH 2 ) 3 -piperidinylene-(CH 2 ) 7 -CH 3 , -(CH 2 ) 4 -piperidinylene-CH 3 , -(CH 2 ) 4 -piperidinylene-CH 2 -CH 3 , -(CH 2 ) 4 -piperidinylene-(CH 2 ) 2 -CH 3 , -(CH 2 ) 4 -piperidinylene-(CH 2 ) 3 -CH 3 , -(CH 2 ) 4 -piperidinylene-(CH 2 ) 4 -CH 3 , -(CH 2 ) 4 -piperidinylene-(CH 2 ) 5 -CH 3 , -(CH 2 ) 4 -piperidinylene-(CH 2 ) 6 -CH 3 , -(CH 2 ) 4 -piperidinylene-(CH 2 ) 7 -CH 3 , -(CH 2 ) 5 -piperidinylene-CH 3 , - (CH 2 ) 5 -piperidinylene-CH 2 -CH 3 , -(CH 2 ) 5 -piperidinylene-(CH 2 ) 2 -CH 3 , -(CH 2 ) 5 -piperidinylene-(CH 2 ) 3 -CH 3 , -(CH 2 ) 5 -piperidinylene-(CH 2 ) 4 -CH 3 , -(CH 2 ) 5 -piperidinylene-(CH 2 ) 5 -CH 3 , -(CH 2 ) 5 -piperidinylene-(CH 2 ) 6 -CH 3 , -(CH 2 ) 5 -piperidinylene-(CH 2 ) 7 -CH 3 , -(CH 2 ) 6 -piperidinylene-CH 3 , - (CH 2 ) 6 -piperidinylene-CH 2 -CH 3 , -(CH 2 ) 6 -piperidinylene-(CH 2 ) 2 -CH 3 , -(CH 2 ) 6 -piperidinylene-(CH 2 ) 3 -CH 3 , -(CH 2 ) 6 -piperidinylene-(CH 2 ) 4 -CH 3 , -(CH 2 ) 6 -piperidinylene-(CH 2 ) 5 -CH 3 , -(CH 2 ) 6 -piperidinylene-(CH 2 ) 6 -CH 3 , -(CH 2 ) 6 -piperidinylene-(CH 2 ) 7 -CH 3 , -(CH 2 ) 7 -piperidinylene-CH 3 , - (CH 2 ) 7 -piperidinylene-CH 2 -CH 3 , -(CH 2 ) 7 -piperidinylene-(CH 2 ) 2 -CH 3 , -(CH 2 ) 7 -piperidinylene-(CH 2 ) 3 -CH 3 , -(CH 2 ) 7 -piperidinylene-(CH 2 ) 7 -CH 3 , -(CH 2 ) 8 -piperidinylene-CH 3 , -(CH 2 ) 8 -piperidinylene-CH 2 -CH 3 , -(CH 2 ) 8 -piperidinylene-(CH 2 ) 2 -CH 3 , -(CH 2 ) 8 -piperidinylene-(CH 2 ) 3 -CH 3 , -(CH 2 ) 8 -piperidinylene-(CH 2 ) 4 -CH 3 , -(CH 2 ) 8 -piperidinylene-(CH 2 ) 5 -CH 3 , -(CH 2 ) 8 -piperidinylene-(CH 2 ) 6 -CH 3 , -(CH 2 ) 8 -piperidinylene-(CH 2 ) 7 -CH 3 , -CH 2 -N(R e )-CH 2 -piperidinylene-CH 3 , -CH 2 -N(R e )-CH 2 -piperidinylene-CH 3 , -CH 2 -N(R e )-CH 2 -piperidinylene-(CH 2 ) 2 -CH 3 , -CH 2 -N(R e )-CH 2 -piperidinylene-(CH 2 ) 3 -CH 3 , -CH 2 -N(R e )-CH 2 -piperidinylene-(CH 2 ) 4 -CH 3 , -CH 2 -N(R e )-CH 2 -piperidinylene-(CH 2 ) 5 -CH 3 , -CH 2 -N(R e )-CH 2 -piperidinylene-(CH 2 ) 6 -CH 3 , -CH 2 -N(R e )-CH 2 -piperidinylene-(CH 2 ) 7 -CH 3 , - CH 2 -N(R e )-(CH 2 ) 2 -piperidinylene-CH 3 , -CH 2 -N(R e )-(CH 2 ) 2 -piperidinylene-CH 2 -CH 3 , -CH 2 -N(R e )-(CH 2 ) 2 -piperidinylene-(CH 2 ) 2 -CH 3 , -CH 2 -N(R e )-(CH 2 ) 2 -piperidinylene-(CH 2 ) 3 -CH 3 , -CH 2 -N(R e )-(CH 2 ) 2 -piperidinylene-(CH 2 ) 4 -CH 3 , -CH 2 -N(R e )-(CH 2 ) 2 -pipendinylene-(CH 2 ) 5 -CH 3 , -CH 2 -N(R e )-(CH 2 ) 2 -piperidinylene-(CH 2 ) 6 -CH 3 , -CH 2 -N(R e )-(CH 2 ) 2 -piperidinylene-(CH 2 ) 7 -CH 3 , -(CH 2 ) 2 -N(R e )-CH 2 -piperidinylene-CH 3 , -(CH 2 ) 2 -N(R e )-CH 2 -piperidinylene-CH 2 -CH 3 , -(CH 2 ) 2 -N(R e )-CH 2 -piperidinylene-(CH 2 ) 2 -CH 3 , -(CH 2 ) 2 -N(R e )-CH 2 -piperidinylene-(CH 2 ) 3 -CH 3 , -(CH 2 ) 2 -N(R e )-CH 2 -piperidinylene-(CH 2 ) 4 -CH 3 , -(CH 2 ) 2 -N(R e )-CH 2 -piperidinylene-(CH 2 ) 5 -CH 3 , -(CH 2 ) 2 -N(R e )-CH 2 -piperidinylene-(CH 2 ) 6 -CH 3 , -(CH 2 ) 2 -N(R e )-CH 2 -piperidinylene-(CH 2 ) 7 -CH 3 , -(CH 2 ) 3 -N(R e )-CH 2 -piperidinylene-CH 3 , -(CH 2 ) 3 -N(R e )-CH 2 -piperidinylene-CH 2 -CH 3 , -(CH 2 ) 3 -N(R e )-CH 2 -piperidinylene-(CH 2 ) 2 -CH 3 , -(CH 2 ) 3 -N(R e )-CH 2 -piperidinylene-(CH 2 ) 7 -CH 3 , -(CH 2 ) 4 -N(R e )-CH 2 -piperidinylene-CH 3 , -(CH 2 ) 4 -N(R e )-CH 2 -piperidinylene-CH 2 -CH 3 , -(CH 2 ) 4 -N(R e )-CH 2 -piperidinylene-(CH 2 ) 2 -CH 3 , - (CH 2 ) 4 -N(R e )-CH 2 -piperidinylene-(CH 2 ) 7 -CH 3 , -(CH 2 ) 5 -N(R e )-CH 2 -piperidinylene-(CH 2 ) 2 -CH 3 , - (CH 2 ) 5 -N(R e )-CH 2 -piperidinylene-(CH 2 ) 7 -CH 3 , -(CH 2 ) 6 -N(R e )-CH 2 -piperidinylene-(CH 2 ) 2 -CH 3 , - (CH 2 ) 6 -N(R e )-CH 2 -piperidinylene-(CH 2 ) 7 -CH 3 , -(CH 2 ) 7 -N(R e )-CH 2 -piperidinylene-(CH 2 ) 2 -CH 3 , - (CH 2 ) 7 -N(R e )-CH 2 -piperidinylene-(CH 2 ) 7 -CH 3 , -(CH 2 ) 8 -N(R e )-CH 2 -piperidinylene-CH 3 , -(CH 2 ) 8 -N(R e )-CH 2 -piperidinylene-CH 2 -CH 3 , -(CH 2 ) 8 -N(R e )-CH 2 -piperidinylene-(CH 2 ) 2 -CH 3 , -(CH 2 ) 8 -N(R e )-CH 2 -piperidinylene-(CH 2 ) 3 -CH 3 , -(CH 2 ) 8 -N(R e )-CH 2 -piperidinylene-(CH 2 ) 4 -CH 3 , -(CH 2 ) 8 -N(R e )-CH 2 -piperidinylene-(CH 2 ) 5 -CH 3 , -(CH 2 ) 8 -N(R e )-CH 2 -piperidinylene-(CH 2 ) 6 -CH 3 , -(CH 2 ) 8 -N(R e )-CH 2 -piperidinylene-(CH 2 ) 7 -CH 3 , -CH 2 -piperazinylene-CH 3 , -CH 2 -piperazinylene-CH 2 -CH 3 , -CH 2 -piperazinylene-(CH 2 ) 2 -CH 3 , -CH 2 -piperazinylene-(CH 2 ) 3 -CH 3 , -CH 2 -piperazinylene-(CH 2 ) 4 -CH 3 , - CH 2 -piperazinylene-(CH 2 ) 5 -CH 3 , -CH 2 -piperazinylene-(CH 2 ) 6 -CH 3 , -CH 2 -piperazinylene-(CH 2 ) 7 -CH 3 , -(CH 2 ) 2 -piperazinylene-CH 3 , -(CH 2 ) 2 -piperazinylene-CH 2 -CH 3 , -(CH 2 ) 2 -piperazinylene-(CH 2 ) 2 -CH 3 , - (CH 2 ) 2 -piperazinylene-(CH 2 ) 3 -CH 3 , -(CH 2 ) 2 -piperazinylene-(CH 2 ) 4 -CH 3 , -(CH 2 ) 2 -piperazinylene-(CH 2 ) 5 -CH 3 , -(CH 2 ) 2 -piperazinylene-(CH 2 ) 6 -CH 3 , -(CH 2 ) 2 -piperazinylene-(CH 2 ) 7 -CH 3 , -(CH 2 ) 3 -piperazinylene-CH 3 , -(CH 2 ) 3 -piperazinylene-CH 2 -CH 3 , -(CH 2 ) 3 -piperazinylene-(CH 2 ) 2 -CH 3 , -(CH 2 ) 3 -piperazinylene-(CH 2 ) 3 -CH 3 , -(CH 2 ) 3 -piperazinylene-(CH 2 ) 4 -CH 3 , -(CH 2 ) 3 -piperazinylene-(CH 2 ) 5 -CH 3 , -(CH 2 ) 3 -piperazinylene-(CH 2 ) 6 -CH 3 , -(CH 2 ) 3 -piperazinylene-(CH 2 ) 7 -CH 3 , -(CH 2 ) 4 -piperazinylene-CH 3 , -(CH 2 ) 4 -piperazinylene-CH 2 -CH 3 , -(CH 2 ) 4 -piperazinylene-(CH 2 ) 2 -CH 3 , -(CH 2 ) 4 -piperazinylene-(CH 2 ) 3 -CH 3 , -(CH 2 ) 4 -piperazinylene-(CH 2 ) 4 -CH 3 , -(CH 2 ) 4 -piperazinylene-(CH 2 ) 5 -CH 3 , -(CH 2 ) 4 -piperazinylene-(CH 2 ) 6 -CH 3 , -(CH 2 ) 4 -piperazinylene-(CH 2 ) 7 -CH 3 , -(CH 2 ) 5 -piperazinylene-CH 3 , - (CH 2 ) 5 -piperazinylene-CH 2 -CH 3 , -(CH 2 ) 5 -piperazinylene-(CH 2 ) 2 -CH 3 , -(CH 2 ) 5 -piperazinylene-(CH 2 ) 3 -CH 3 , -(CH 2 ) 5 -piperazinylene-(CH 2 ) 4 -CH 3 , -(CH 2 ) 5 -piperazinylene-(CH 2 ) 5 -CH 3 , -(CH 2 ) 5 -piperazinylene-(CH 2 ) 6 -CH 3 , -(CH 2 ) 5 -piperazinylene-(CH 2 ) 7 -CH 3 , -(CH 2 ) 6 -piperazinylene-CH 3 , - (CH 2 ) 6 -piperazinylene-CH 2 -CH 3 , -(CH 2 ) 6 -piperazinylene-(CH 2 ) 2 -CH 3 , -(CH 2 ) 6 -piperazinylene-(CH 2 ) 3 -CH 3 , -(CH 2 ) 6 -piperazinylene-(CH 2 ) 4 -CH 3 , -(CH 2 ) 6 -piperazinylene-(CH 2 ) 5 -CH 3 , -(CH 2 ) 6 -piperazinylene-(CH 2 ) 6 -CH 3 , -(CH 2 ) 6 -piperazinylene-(CH 2 ) 7 -CH 3 , -(CH 2 ) 7 -piperazinylene-CH 3 , - (CH 2 ) 7 -piperazinylene-CH 2 -CH 3 , -(CH 2 ) 7 -piperazinylene-(CH 2 ) 2 -CH 3 , -(CH 2 ) 7 -piperazinylene-(CH 2 ) 3 -CH 3 , -(CH 2 ) 7 -piperazinylene-(CH 2 ) 7 -CH 3 , -(CH 2 ) 8 -piperazinylene-CH 3 , -(CH 2 ) 8 -piperazinylene-CH 2 -CH 3 , -(CH 2 ) 8 -piperazinylene-(CH 2 ) 2 -CH 3 , -(CH 2 ) 8 -piperazinylene-(CH 2 ) 3 -CH 3 , -(CH 2 ) 8 -piperazinylene-(CH 2 ) 4 -CH 3 , -(CH 2 ) 8 -piperazinylene-(CH 2 ) 5 -CH 3 , -(CH 2 ) 8 -piperazinylene-(CH 2 ) 6 -CH 3 , or -(CH 2 ) 8 -piperazinylene-(CH 2 ) 7 -CH 3 ; wherein the piperidinylene and piperazinylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C 1-6 alkyl (e.g., optionally deuterated C 1-4 alkyl, such as methyl, CD 3 , ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), optionally deuterated C 3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl, or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, halogen (e.g., fluorine, chlorine, bromine, or iodine), optionally deuterated C 1-6 alkoxy (e.g., optionally deuterated C 1-4 alkoxy, such as methoxy, CD 3 -O-, ethoxy, propoxy, isopropoxy, n-butoxy, sec-butoxy, or tert-butoxy), optionally deuterated C 1-6 alkyl-NH- (e.g., optionally deuterated C 1-3 alkyl-NH-, such as CH 3 NH-, CH 3 CH 2 NH- or CH 3 CH 2 CH 2 NH-), halogenated C 1-6 alkyl (e.g., halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), NH 2 -C 1-6 alkylene (e.g., NH 2 -C 1-3 alkylene-, such as NH 2 CH 2 -, NH 2 CH 2 CH 2 - and NH 2 CH 2 CH 2 CH 2 -), optionally deuterated C 1-6 alkyl-NHC(O)- (e.g., optionally deuterated C 1-4 alkyl-NHC(O)-, such as CH 3 -NHC(O)-, CH 3 CH 2 -NHC(O)-, and CH 3 CH 2 CH 2 -NHC(O)-), optionally deuterated C 1-6 alkyl-C(O)NH- (e.g., optionally deuterated C 1-4 alkyl-C(O)NH-, such as CH 3 -C(O)NH-, CH 3 CH 2 -C(O)NH-, and CH 3 CH 2 CH 2 -C(O)NH-), cyano, or any combination thereof; a hydrogen atom of CH 3 of the groups and a hydrogen atom of one or more (e.g., 1-30, such as 1-25, 1-20, 1-15, 1-10, 1-5, 1-4, 1-3, 1-2 or 1) CH 2 of the groups are optionally substituted with a substituent selected from the group consisting of deuterium, hydroxy, amino, mercapto, nitro, halogen (e.g., fluorine, chlorine, bromine, or iodine), cyano, optionally deuterated C 1-6 alkyl (e.g., optionally deuterated C 1-4 alkyl, such as methyl, CD 3 , ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 alkyl (e.g., halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), optionally deuterated C 3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl, or optionally perdeuterated cyclohexyl), optionally deuterated C 1-6 alkoxy (e.g., optionally deuterated C 1-4 alkoxy, such as methoxy, CD 3 -O-, ethoxy, propoxy, isopropoxy, n-butoxy, sec-butoxy, or tert-butoxy), optionally deuterated C 1-6 alkyl-NH- (e.g., optionally deuterated C 1-3 alkyl-NH-, such as CH 3 NH-, CH 3 CH 2 NH- or CH 3 CH 2 CH 2 NH-), NH 2 -C 1-6 alkylene (e.g., NH 2 -C 1-3 alkylene-, such as NH 2 CH 2 -, NH 2 CH 2 CH 2 - and NH 2 CH 2 CH 2 CH 2 -), optionally deuterated C 1-6 alkyl-NHC(O)- (e.g., optionally deuterated C 1-4 alkyl-NHC(O)-, such as CH 3 -NHC(O)-, CH 3 CH 2 -NHC(O)-, and CH 3 CH 2 CH 2 -NHC(O)-), optionally deuterated C 1-6 alkyl-C(O)NH- (e.g., optionally deuterated C 1-4 alkyl-C(O)NH-, such as CH 3 -C(O)NH-, CH 3 CH 2 -C(O)NH-, and CH 3 CH 2 CH 2 -C(O)NH-) or any combination thereof; ach R e independently represents H or C 1-6 alkyl (e.g., C 1-4 alkyl, such as methyl, CD 3 , ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl); and n1, n2, n3, n4, m4, m5, and m6 each independently represent an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

[0055] In some embodiments, R 5 and R 6 of the compound of Formula (I) represent hydrogen.

[0056] In some embodiments, (R b ) n of the compound of Formula (I) indicates that the benzene ring is substituted with n R b substituents, with each R b being the same or different and independently representing hydrogen, deuterium, halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxy, mercapto, nitro, amino, cyano, optionally deuterated C 1-6 alkyl (e.g., optionally deuterated C 1-4 alkyl, such as methyl, CD 3 , ethyl, propyl, isopropyl, butyl, sec-butyl, or tert-butyl), optionally deuterated C 1-6 alkoxy (e.g., optionally deuterated C 1-4 alkoxy, such as methoxy, CD 3 -O-, ethoxy, propoxy, isopropoxy, n-butoxy, sec-butoxy, or tert-butoxy), halogenated C 1-6 alkyl (e.g., halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), optionally substituted C 3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl, or optionally perdeuterated cyclohexyl), C 2-6 alkenyl (e.g., vinyl, propenyl, or butenyl) or C 2-6 alkynyl (e.g., ethynyl, propynyl, or butynyl); and wherein n represents an integer of 0, 1, 2, or 3. In some sub-embodiments, the substituents of the optionally substituted C 3-6 cycloalkyl are selected from C 1 -C 3 alkyl, C 3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, C 1 -C 3 alkoxy, C 1 -C 3 alkyl-NH-, halogenated C 1 -C 3 alkyl, NH 2 -C 1-3 alkylene, C 1-3 alkyl-NHC(O)-, C 1-3 alkyl-C(O)NH-, cyano or any combination thereof; and the number of substituents can be one or more (e.g., 1-5, 1-4, 1-3, 1-2, or 1). The number of substituents is not theoretically limited in any way or automatically limited by the size of the building units.

[0057] In some embodiments, the compound of Formula (I) is also of Formula (1-1) or Formula (1-2): wherein A, R 1 , R 2 , R 3 , R 4 , (R b ) n and (R a ) m are as defined in the compound of Formula (I) and its various embodiments above.

[0058] In some embodiments, the compound of Formula (I) is also of Formula (1-3) or Formula (1-4): wherein A, (R b ) n and (R a ) m are as defined in the compound of Formula (I) and its various embodiments above.

[0059] In some embodiments, the compound of Formula (I) is also of Formula (1-5), Formula (1-6), Formula (1-7) or Formula (1-8): wherein A, R 1 , R 2 , R 3 , R 4 , (R b ) n and R a are as defined in the compound of Formula (I) and its various embodiments above.

[0060] In some embodiments, in the compounds of Formula (1-5), (1-6), (1-7) or (I-8), A represents CO, CH 2 or CD 2 ; R 1 , R 2 , R 3 and R 4 are the same or different and each independently represent hydrogen, deuterium, halogen (e.g., fluorine, chlorine, bromine, or iodine), optionally deuterated C 1-6 alkyl (e.g., optionally deuterated C 1-4 alkyl, such as methyl, CD 3 , ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), optionally deuterated C 1-6 alkoxy (e.g., optionally deuterated C 1-4 alkoxy, such as methoxy, CD 3 -O-, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy, or tert-butoxy), or halogenated C 1-6 alkyl (e.g., halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -); (R a ) m indicates that benzene ring is substituted with m R a substituents, with each R a being the same or different and independently representing the structure of the following formula: wherein R represents chlorine, bromine, iodine, hydroxy, leaving group (e.g., -N 3 , chlorine, bromine, iodine, sulfonate, such as methanesulfonyloxy (MsO-), trifluoromethanesulfonyloxy (TfO-) or p-toluenesulfonyloxy (TsO-)), NR 7 R 8 or W 1< , wherein R 7 and R 8 are the same or different and each independently represent hydrogen, C 1-6 alkyl (e.g., C 1-4 alkyl or C 1-3 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), C 2-6 alkynyl-C 1-6 alkylene- (e.g., C 2-6 alkynyl-C 1-4 alkylene- or C 2-6 alkynyl-C 1-3 alkylene-, such as ethynyl-methylene-, ethynyl-ethylene-, ethynyl-propylene-, ethynyl-butylene-, ethynyl-pentylene-, or ethynyl-hexylene-), C 2-6 alkenyl-C 1-6 alkylene- (e.g., C 2-6 alkenyl-C 1-4 alkylene- or C 2-6 alkenyl-C 1-3 alkylene-, such as vinyl-methylene-, vinyl-ethylene-, vinyl-propylene-, vinyl-butylene-, vinyl-pentylene-, or vinyl-hexylene-), optionally substituted 4- to 15-membered (e.g., 4- to 11-membered, 4- to 10-membered, 4- to 9-membered, 4- to 8-membered, 4- to 7-membered, 4- to 6-membered, 5- to 15-membered, or 5- to 9-membered) nitrogen-containing heterocyclyl, or R 2a< -R 1a< -, where R 1a< is optionally substituted C 1-6 alkylene (e.g., optionally substituted C 1-4 alkylene, such as optionally substituted methylene, ethylene, or propylene) or optionally substituted C 2-6 alkenylene (e.g., optionally substituted C 2-4 alkenylene, such as optionally substituted vinylene, propenylene, or butenylene), and R 2a< represents halogen (e.g., fluorine, chlorine, bromine, or iodine), amino, hydroxy, carboxyl, C 2-6 alkynyl (e.g., C 2-4 alkynyl, such as ethynyl, propynyl, or butynyl), C 2-6 alkenyl (e.g., C 2-4 alkenyl, such as vinyl, propenyl, or butenyl) or a leaving group (e.g., -N 3 , chlorine, bromine, iodine, sulfonate, e.g., methanesulfonyloxy (MsO-), trifluoromethanesulfonyloxy (TfO-), or p-toluenesulfonyloxy (TsO-)); and W 1< represents the structure of the following formula: wherein ring W 2< represents optionally substituted nitrogen-containing heterocyclyl (e.g., optionally substituted 4- to 20-membered nitrogen-containing heterocyclyl), and each ring W 3< is the same or different and each independently represents optionally substituted nitrogen-containing heterocyclylene (e.g., optionally substituted 4- to 20-membered nitrogen-containing heterocyclylene), t represents an integer of 1 or 2, and ring W 4< represents optionally substituted aryl (e.g., optionally substituted 6- to 10-membered aryl), optionally substituted heteroaryl (e.g., optionally substituted 5- to 10-membered heteroaryl) or optionally substituted heterocyclyl (e.g., 4- to 15-membered nitrogen-containing heterocyclyl); R 5 and R 6 are the same or different and each independently represent hydrogen, fluorine, chlorine, bromine, iodine, optionally substituted methyl, or optionally substituted linear or branched C 2-30 alkyl, wherein one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, 1-2, or 1) groups R c and / or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, 1-2, or 1) groups R d and / or any combination of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, 1-2, or 1) groups R c and R d are optionally inserted into the backbone carbon chain of the linear or branched C 2-30 alkyl group, wherein carbon-carbon bond between one or more (e.g., 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, 1-2, or 1) pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R c , R d , or a combination of R c and R d ; wherein each R c is selected from the group consisting of O, N(R e ), C(O), C(O)O, S(O), S(O) 2 , S(O) 2 NH, NHS(O) 2 , OC(O), C(O)N(R e ), N(R e )C(O), or N(R e )C(O)N(R e ), where each R e independently represents H or C 1-6 alkyl (e.g., C 1-4 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), and in case that two or more groups R c are inserted into the backbone carbon chain of the linear or branched C 2-30 alkyl group, the two or more groups R c are not directly connected to each other; and wherein each R d is selected from the group consisting of cycloalkylene (e.g., C 3-20 cycloalkylene), arylene (e.g., C 3-20 arylene), heterocyclylene (e.g., 4- to 20-membered heterocyclylene), heteroarylene (e.g., 4- to 20-membered heteroarylene), alkynylene (e.g., C 2-6 alkynylene), alkenylene (e.g., C 2-6 alkenylene), or any combination thereof, wherein the cycloalkylene, arylene, heterocyclylene, and heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, (e.g., optionally deuterated C 1-4 alkyl, such as methyl, CD 3 , ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), optionally deuterated C 3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl, or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, halogen (e.g., fluorine, chlorine, bromine, or iodine), cyano, optionally deuterated C 1-6 alkoxy (e.g., optionally deuterated C 1-4 alkoxy, such as methoxy, CD 3 -O-, ethoxy, propoxy, isopropoxy, n-butoxy, sec-butoxy, or tert-butoxy), optionally deuterated C 1-6 alkyl-NH- (e.g., optionally deuterated C 1-3 alkyl-NH-, such as CH 3 NH-, CH 3 CH 2 NH- or CH 3 CH 2 CH 2 NH-), halogenated C 1-6 alkyl (e.g., halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), NH 2 -C 1-6 alkylene (e.g., NH 2 -C 1-3 alkylene-, such as NH 2 CH 2 -, NH 2 CH 2 CH 2 - and NH 2 CH 2 CH 2 CH 2 -), optionally deuterated C 1-6 alkyl-NHC(O)- (e.g., optionally deuterated C 1-4 alkyl-NHC(O)-, such as CH 3 -NHC(O)-, CH 3 CH 2 -NHC(O)-, and CH 3 CH 2 CH 2 -NHC(O)-), optionally deuterated C 1-6 alkyl-C(O)NH- (e.g., optionally deuterated C 1-4 alkyl-C(O)NH-, such as CH 3 -C(O)NH-, CH 3 CH 2 -C(O)NH-, and CH 3 CH 2 CH 2 -C(O)NH-), or any combination thereof; or R and R 5 together with the carbon atom to which they are connected form carbonyl group, and R 6 represents hydrogen, optionally substituted methyl, or linear or branched C 2-30 alkyl, wherein one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, 1-2, or 1) groups R c and / or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, 1-2, or 1) groups R d and / or any combination of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, 1-2, or 1) groups R c and R d are optionally inserted into the backbone carbon chain of the linear or branched C 2-30 alkyl group, wherein carbon-carbon bond between one or more (e.g., 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, 1-2, or 1) pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group R c , R d , or a combination of R c and R d ; wherein each R c is selected from the group consisting of O, N(R e ), C(O), C(O)O, S(O), S(O) 2 , S(O) 2 NH, NHS(O) 2 , OC(O), C(O)N(R e ), N(R e )C(O), or N(R e )C(O)N(R e ), where each R e independently represents H or C 1-6 alkyl (e.g., C 1-4 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), and in case that two or more groups R c are inserted into the backbone carbon chain of the linear or branched C 2-30 alkyl group, the two or more groups R c are not directly connected to each other; and wherein each R d is selected from the group consisting of cycloalkylene (e.g., C 3-20 cycloalkylene), arylene (e.g., C 3-20 arylene), heterocyclylene (e.g., 4- to 20-membered heterocyclylene), heteroarylene (e.g., 4- to 20-membered heteroarylene), alkynylene (e.g., C 2-6 alkynylene), alkenylene (e.g., C 2-6 alkenylene), or any combination thereof, wherein the cycloalkylene, arylene, heterocyclylene, and heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C 1-6 alkyl (e.g., optionally deuterated C 1-4 alkyl, such as methyl, CD 3 , ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), optionally deuterated C 3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl, or optionally perdeuterated cyclohexyl), hydroxy, amino, mercapto, halogen (e.g., fluorine, chlorine, bromine, or iodine), optionally deuterated C 1-6 alkoxy (e.g., optionally deuterated C 1-4 alkoxy, such as methoxy, CD 3 -O-, ethoxy, propoxy, isopropoxy, n-butoxy, sec-butoxy, or tert-butoxy), optionally deuterated C 1-6 alkyl-NH- (e.g., optionally deuterated C 1-3 alkyl-NH-, such as CH 3 NH-, CH 3 CH 2 NH- or CH 3 CH 2 CH 2 NH-), halogenated C 1-6 alkyl (e.g., halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), NH 2 -C 1-6 alkylene (e.g., NH 2 -C 1-3 alkylene-, such as NH 2 CH 2 -, NH 2 CH 2 CH 2 - and NH 2 CH 2 CH 2 CH 2 -), optionally deuterated C 1-6 alkyl-NHC(O)- (e.g., optionally deuterated C 1-4 alkyl-NHC(O)-, such as CH 3 -NHC(O)-, CH 3 CH 2 -NHC(O)-, and CH 3 CH 2 CH 2 -NHC(O)-), optionally deuterated C 1-6 alkyl-C(O)NH- (e.g., optionally deuterated C 1-4 alkyl-C(O)NH-, such as CH 3 -C(O)NH-, CH 3 CH 2 -C(O)NH-, and CH 3 CH 2 CH 2 -C(O)NH-), cyano, or any combination thereof; (R b ) n indicates that the benzene ring is substituted with n R b substituents, with each R b being the same or different and independently representing hydrogen, deuterium, halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxy, mercapto, nitro, amino, cyano, optionally deuterated C 1-6 alkyl (e.g., optionally deuterated C 1-4 alkyl, such as methyl, CD 3 , ethyl, propyl, isopropyl, butyl, sec-butyl, or tert-butyl), optionally deuterated C 1-6 alkoxy (e.g., optionally deuterated C 1-4 alkoxy, such as methoxy, CD 3 -O-, ethoxy, propoxy, isopropoxy, n-butoxy, sec-butoxy, or tert-butoxy), halogenated C 1-6 alkyl (e.g., halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), optionally substituted C 3-6 cycloalkyl (e.g., optionally perdeuterated cyclopropyl, optionally perdeuterated cyclobutyl, optionally perdeuterated cyclopentyl, or optionally perdeuterated cyclohexyl), C 2-6 alkenyl (e.g., vinyl, propenyl, or butenyl) or C 2-6 alkynyl (e.g., ethynyl, propynyl, or butynyl); and m represents an integer of 1, 2, 3, or 4, n represents an integer of 0, 1, 2, or 3, and the sum of m and n is an integer of 1, 2, 3, or 4; wherein when R and R 5 together with the carbon atom to which they are connected form a carbonyl group and R 6 represents hydrogen, m represents an integer of 1, 2, or 3, n represents an integer of 1, 2, or 3, and the sum of m and n is an integer of 2, 3, or 4; with the proviso that the following compounds and compounds of Formula (I') are excluded: and when A represents CH 2 or C(O) and R represents unsubstituted piperazinyl, m represents an integer of 1 and n represents an integer of 0; when A represents CH 2 or C(O) and R a represents H 2 N-CH 2 -, m represents an integer of 1 and n represents an integer of 0; when A represents C(O) and R represents bromine, m represents an integer of 1 and n represents an integer of 0; and the compounds of Formula (I'): wherein A represents CH 2 or C(O), and R represents unsubstituted piperidinyl or methylamino substituted piperidinyl.

[0061] In some embodiments, the compounds of Formula (I) and their salts (including pharmaceutically acceptable salts, such as hydrochloride, etc.), prodrugs, solvates, isotopically enriched analogs, polymorphs, stereoisomers (including enantiomers and diastereomers), or mixture of stereoisomers thereof in Table 1 below are provided: Compounds of Formula (II)

[0062] The present disclosure provides a compound of Formula (II) or salts (including pharmaceutically acceptable salts), stereoisomers (including enantiomers), solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof:         PBM-R f -LIN-ULM     Formula (II) wherein PBM, R f , LIN and ULM are as defined in the compounds of Formula (II) above.

[0063] The compound of Formula (II) of the present disclosure does not comprise the following compounds: 3 -(4-((3 -(4-amino-3 -(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1 - yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; N-(5-(3,5-difluorobenzyl)-1H-indazol-3-yl)-4-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperidin-3-yl)piperazin-1-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide; N-(5-(3,5-difluorobenzyl)-1H-indazol-3-yl)-4-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)methyl)piperazin-1-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide; N-(5-(3,5-difluorobenzyl)-1H-indazol-3-yl)-4-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-3-oxoisoindolin-5-yl)methyl)piperidin-3-yl)piperazin-1-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide; N-(5-(3,5-difluorobenzyl)-1H-indazol-3-yl)-4-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-1-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide; N-(5-(3,5-difluorobenzyl)-1H-indazol-3-yl)-4-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)methyl)pyrrolidin-3-yl)piperazin-1-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide; N-(5-(3,5-difluorobenzyl)-1H-indazol-3-yl)-4-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)methyl)piperidin-3-yl)piperazin-1-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide; N-(5-(3,5-difluorobenzyl)-1H-indazol-3-yl)-4-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)methyl)azetidin-3-yl)piperazin-1-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide; 2-(2,6-dioxopiperidin-3-yl)-5-((4-(6-(6-(2-(3-fluorophenyl)pyrrolidin-l-yl)imidazo[1,2-b]pyridazin-3-yl)pyridin-2-yl)piperazin-1-yl)methyl)isoindoline-1,3-dione; and 2-(2,6-dioxopiperidin-3-yl)-5-((3-(4-(6-(6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3 -yl)pyridin-2-yl)piperazin-1-yl)azetidin-1-yl)methyl)isoindoline-1,3 -dione.

[0064] The compound of Formula (II) or salts (including pharmaceutically acceptable salts), stereoisomers (including enantiomers), solvates, isotope enriched analogues, prodrugs, or polymorphs thereof of the present disclosure can bind to target proteins, recruit target proteins to E3 ubiquitin ligases for ubiquitination labeling and degradation. The compound of Formula (II) of the present disclosure can specifically target specific type or family of target protein, and exhibit a wide range of pharmacological activities by degrading / inhibiting diverse types or families of target proteins.

[0065] In some embodiments, specific target protein includes, but is not limited to, the target proteins in Table 2: Table 2. Applicable specific target proteinsabbreviation of target proteintarget protein's nameChinese translation of target protein's nameCas9CRISPR-associated endonuclease Cas9CRISPR-associated endonuclease Cas9SHP2Src homology 2 domain containing protein tyrosine phosphataseSrc homology 2 domain containing protein tyrosine phosphataseEREstrogen receptorEstrogen receptorARAndrogen receptorAndrogen receptorBTKBruton tyrosine kinaseBruton tyrosine kinaseIRAK4Interleukin-1 receptor-associated kinase 4Interleukin-1 receptor-associated kinase 4EGFREpidermal growth factor receptorEpidermal growth factor receptorMETHepatocyte growth factor receptorHepatocyte growth factor receptorKITMast / stem cell growth factor receptor KitMast / stem cell growth factor receptor KitEPHA2Ephrin type-A receptor 2Ephrin type-A receptor 2PDE4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DcAMP-specific 3',5'-cyclic phosphodiesterase 4DSRCProto-oncogene tyrosine-protein kinase SrcProto-oncogene tyrosine-protein kinase SrcBRAFSerine / threonine-protein kinase B-rafSerine / threonine-protein kinase B-rafFGFR(fibroblast growth factor receptors,FGFRs)(fibroblast growth factor receptors,FGFRs)FGFR2Fibroblast growth factor receptor 2Fibroblast growth factor receptor 2FGFR1Fibroblast growth factor receptor 1Fibroblast growth factor receptor 1LYNTyrosine-protein kinase LynTyrosine-protein kinase LynITKTyrosine-protein kinase ITK / TSKTyrosine-protein kinase ITK / TSKPARP1Poly [ADP-ribose] polymerase 1Poly [ADP-ribose] polymerase 1HDAC2Histone deacetylase 2Histone deacetylase 2HDAC3Histone deacetylase 3Histone deacetylase 3JAK1Tyrosine-protein kinase JAK1Tyrosine-protein kinase JAK1BCL2Apoptosis regulator Bcl-2Apoptosis regulator Bcl-2HDAC6Histone deacetylase 6Histone deacetylase 6CRBNProtein cereblonProtein cereblonEPHB2Ephrin type-B receptor 2Ephrin type-B receptor 2BLKTyrosine-protein kinase BlkTyrosine-protein kinase BlkHDAC1Histone deacetylase 1Histone deacetylase 1IGF1RInsulin-like growth factor 1 receptorInsulin-like growth factor 1 receptorTGFBR1TGF-beta receptor type-1TGF-beta receptor type-1AKT2RAC-beta serine / threonine-protein kinaseRAC-beta serine / threonine-protein kinaseAKT1RAC-alpha serine / threonine-protein kinaseRAC-alpha serine / threonine-protein kinaseFAKFocal adhesion kinaseFocal adhesion kinaseMAPK1Mitogen-activated protein kinase 1Mitogen-activated protein kinase 1MAPK14Mitogen-activated protein kinase 14Mitogen-activated protein kinase 14CDK9Cyclin-dependent kinase 9Cyclin-dependent kinase 9MCL1Induced myeloid leukemia cell differentiation protein Mcl-1Induced myeloid leukemia cell differentiation protein Mcl-1BETBromodomain and extra-terminal domain proteinBromodomain and extra-terminal domain proteinBRD4Bromodomain-containing protein 4Bromodomain-containing protein 4BRD3Bromodomain-containing protein 3Bromodomain-containing protein 3CDK13Cyclin-dependent kinase 13Cyclin-dependent kinase 13BCL2L1Bcl-2-like protein 1Bcl-2-like protein 1CDK12Cyclin-dependent kinase 12Cyclin-dependent kinase 12CDK1Cyclin-dependent kinase 1Cyclin-dependent kinase 1AKT3RAC-gamma serine / threonine-protein kinaseRAC-gamma serine / threonine-protein kinaseCDK11BCyclin-dependent kinase 11BCyclin-dependent kinase 11BPAK4Serine / threonine-protein kinase PAK 4Serine / threonine-protein kinase PAK 4MAPKAPK2MAP kinase-activated protein kinase 2MAP kinase-activated protein kinase 2TNK2Activated CDC42 kinase 1Activated CDC42 kinase 1SIRT2NAD-dependent protein deacetylase sirtuin-2NAD-dependent protein deacetylase sirtuin-2DAPK1Death-associated protein kinase 1Death-associated protein kinase 1ABL2Tyrosine-protein kinase ABL2Tyrosine-protein kinase ABL2PRKAA25'-AMP-activated protein kinase catalytic subunit alpha-25'-AMP-activated protein kinase catalytic subunit alpha-2KAT2AHistone acetyltransferase KAT2AHistone acetyltransferase KAT2APBRM1Protein polybromo-1Protein polybromo-1EIF2AK2Interferon-induced, double-stranded RNA-activated protein kinaseInterferon-induced, double-stranded RNA-activated protein kinaseMAP3K7Mitogen-activated protein kinase kinase kinase 7Mitogen-activated protein kinase kinase kinase 7MAPTMicrotubule-associated protein tauMicrotubule-associated protein tauRIPK1Receptor-interacting serine / threonine-protein kinase 1Receptor-interacting serine / threonine-protein kinase 1IRAK1Interleukin-1 receptor-associated kinase 1Interleukin-1 receptor-associated kinase 1MAP4K1Mitogen-activated protein kinase kinase kinase kinase 1Mitogen-activated protein kinase kinase kinase kinase 1MARK4MAP / microtubule affinity-regulating kinase 4MAP / microtubule affinity-regulating kinase 4BRD9Bromodomain-containing protein 9Bromodomain-containing protein 9RIPK2Receptor-interacting serine / threonine-protein kinase 2Receptor-interacting serine / threonine-protein kinase 2LIMK1LIM domain kinase 1LIM domain kinase 1STK38Serine / threonine-protein kinase 38Serine / threonine-protein kinase 38TRIM24Transcription intermediary factor 1-alphaTranscription intermediary factor 1-alphaSMARCA4Transcription activator BRG1Transcription activator BRG1PRKAA15'-AMP-activated protein kinase catalytic subunit alpha-15'-AMP-activated protein kinase catalytic subunit alpha-1TBK1Serine / threonine-protein kinase TBK1Serine / threonine-protein kinase TBK1KRASGTPase KRasGTPase KRasSMARCA2Probable global transcription activator SNF2L2Probable global transcription activator SNF2L2PCNAProliferating cell nuclear antigenProliferating cell nuclear antigenBRD7Bromodomain-containing protein 7Bromodomain-containing protein 7SUZ12Polycomb protein SUZ12Polycomb protein SUZ12IKZF1DNA-binding protein IkarosDNA-binding protein IkarosHTTHuntingtinHuntingtinSNCAAlpha-synucleinAlpha-synucleinSLC9A1Sodium / hydrogen exchanger 1Sodium / hydrogen exchanger 1FERTyrosine-protein kinase FerTyrosine-protein kinase FerMAP4K2Mitogen-activated protein kinase kinase kinase kinase 2Mitogen-activated protein kinase kinase kinase kinase 2DLG4Disks large homolog 4Disks large homolog 4IKZF3Zinc finger protein AiolosZinc finger protein AiolosPDE4AcAMP-specific 3',5'-cyclic phosphodiesterase 4AcAMP-specific 3',5'-cyclic phosphodiesterase 4AHMGCR3-hydroxy-3-methylglutaryl-coenzyme A reductase3-hydroxy-3-methylglutaryl-coenzyme A reductaseABL1Tyrosine-protein kinase ABL1Tyrosine-protein kinase ABL1RARARetinoic acid receptor alphaRetinoic acid receptor alphaFLT3Receptor-type tyrosine-protein kinase FLT3Receptor-type tyrosine-protein kinase FLT3RARGRetinoic acid receptor gammaRetinoic acid receptor gammaVEGFR-1Vascular endothelial growth factor receptor 1Vascular endothelial growth factor receptor 1EZH2Histone-lysine N-methyltransferase EZH2Histone-lysine N-methyltransferase EZH2EPHA1Ephrin type-A receptor 1Ephrin type-A receptor 1AURKAAurora kinase AAurora kinase ACHEK1Serine / threonine-protein kinase Chk1Serine / threonine-protein kinase Chk1WEE1Weel-like protein kinaseWeel-like protein kinasePLK1Serine / threonine-protein kinase PLK1Serine / threonine-protein kinase PLK1CDC7Cell division cycle 7-related protein kinaseCell division cycle 7-related protein kinaseAURKBAurora kinase BAurora kinase BPLK4Serine / threonine-protein kinase PLK4Serine / threonine-protein kinase PLK4MDM2E3 ubiquitin-protein ligase Mdm2E3 ubiquitin-protein ligase Mdm2MAPK6Mitogen-activated protein kinase 6Mitogen-activated protein kinase 6BUB1Mitotic checkpoint serine / threonine-protein kinase BUB1Mitotic checkpoint serine / threonine-protein kinase BUB1ESRRASteroid hormone receptor ERR1Steroid hormone receptor ERR1BCL6B-cell lymphoma 6 proteinB-cell lymphoma 6 proteinMAPK12Mitogen-activated protein kinase 12Mitogen-activated protein kinase 12CRABP2Cellular retinoic acid-binding protein 2Cellular retinoic acid-binding protein 2HIPK1Homeodomain-interacting protein kinase 1Homeodomain-interacting protein kinase 1ADRM1Proteasomal ubiquitin receptor ADRM1Proteasomal ubiquitin receptor ADRM1CDC20Cell division cycle protein 20 homologCell division cycle protein 20 homologBUB1BMitotic checkpoint serine / threonine-protein kinase BUB1 betaMitotic checkpoint serine / threonine-protein kinase BUB1 betaNTRK2BDNF / NT-3 growth factors receptorBDNF / NT-3 growth factors receptorNTRK1High affinity nerve growth factor receptorHigh affinity nerve growth factor receptorCD274Programmed cell death 1 ligand 1Programmed cell death 1 ligand 1NUAK1NUAK family SNF1-like kinase 1NUAK family SNF1-like kinase 1PDCD1Programmed cell death protein 1Programmed cell death protein 1ERBB2Receptor tyrosine-protein kinase erbB-2Receptor tyrosine-protein kinase erbB-2EPHA3Ephrin type-A receptor 3Ephrin type-A receptor 3PIK3CGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoformPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoformMAP2K1Dual specificity mitogen-activated protein kinase kinase 1Dual specificity mitogen-activated protein kinase kinase 1LCKTyrosine-protein kinase LckTyrosine-protein kinase LckMAP2K2Dual specificity mitogen-activated protein kinase kinase 2Dual specificity mitogen-activated protein kinase kinase 2JAK3Tyrosine-protein kinase JAK3Tyrosine-protein kinase JAK3GSK3BGlycogen synthase kinase-3 betaGlycogen synthase kinase-3 betaJAK2Tyrosine-protein kinase JAK2Tyrosine-protein kinase JAK2PRKCIProtein kinase C iota typeProtein kinase C iota typeFKBP1APeptidyl-prolyl cis-trans isomerase FKBP1APeptidyl-prolyl cis-trans isomerase FKBP1ADHODHDihydroorotate dehydrogenaseDihydroorotate dehydrogenasePIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformCDK6Cyclin-dependent kinase 6Cyclin-dependent kinase 6CDK4Cyclin-dependent kinase 4Cyclin-dependent kinase 4PDE4BcAMP-specific 3',5'-cyclic phosphodiesterase 4BcAMP-specific 3',5'-cyclic phosphodiesterase 4BFYNTyrosine-protein kinase FynTyrosine-protein kinase FynTYK2Non-receptor tyrosine-protein kinase TYK2Non-receptor tyrosine-protein kinase TYK2PDK1Pyruvate dehydrogenase 1Pyruvate dehydrogenase 1PDK2Pyruvate dehydrogenase 2Pyruvate dehydrogenase 2PDK3Pyruvate dehydrogenase 3Pyruvate dehydrogenase 3YES1Tyrosine-protein kinase YesTyrosine-protein kinase YesGSK3AGlycogen synthase kinase-3 alphaGlycogen synthase kinase-3 alphaCDK16Cyclin-dependent kinase 16Cyclin-dependent kinase 16CSNK2A1Casein kinase II subunit alphaCasein kinase II subunit alphaCDK7Cyclin-dependent kinase 7Cyclin-dependent kinase 7PTK2BProtein-tyrosine kinase 2-betaProtein-tyrosine kinase 2-betaMAPK10Mitogen-activated protein kinase 10Mitogen-activated protein kinase 10MAPK9Mitogen-activated protein kinase 9Mitogen-activated protein kinase 9MAPK8Mitogen-activated protein kinase 8Mitogen-activated protein kinase 8CDK5Cyclin-dependent-like kinase 5Cyclin-dependent-like kinase 5METAP2Methionine aminopeptidase 2Methionine aminopeptidase 2BRD2Bromodomain-containing protein 2Bromodomain-containing protein 2MAPK3Mitogen-activated protein kinase 3Mitogen-activated protein kinase 3TECTyrosine-protein kinase TecTyrosine-protein kinase TecCDK14Cyclin-dependent kinase 14Cyclin-dependent kinase 14CDK17Cyclin-dependent kinase 17Cyclin-dependent kinase 17MAP3K11Mitogen-activated protein kinase kinase kinase 11Mitogen-activated protein kinase kinase kinase 11RPS6KB1Ribosomal protein S6 kinase beta-1Ribosomal protein S6 kinase beta-1CSKTyrosine-protein kinase CSKTyrosine-protein kinase CSKMERTKTyrosine-protein kinase MerTyrosine-protein kinase MerSTK17BSerine / threonine-protein kinase 17BSerine / threonine-protein kinase 17BCSNK2A2Casein kinase II subunit alpha'Casein kinase II subunit alpha'RPS6KA1Ribosomal protein S6 kinase alpha-1Ribosomal protein S6 kinase alpha-1MAPK13Mitogen-activated protein kinase 13Mitogen-activated protein kinase 13GAKCyclin-G-associated kinaseCyclin-G-associated kinaseCLK1Dual specificity protein kinase CLK1Dual specificity protein kinase CLK1STK4Serine / threonine-protein kinase 4Serine / threonine-protein kinase 4EIF4EEukaryotic translation initiation factor 4EEukaryotic translation initiation factor 4ESTK10Serine / threonine-protein kinase 10Serine / threonine-protein kinase 10LRRK2Leucine-rich repeat serine / threonine-protein kinase 2Leucine-rich repeat serine / threonine-protein kinase 2TAOK3Serine / threonine-protein kinase TAO3Serine / threonine-protein kinase TAO3MARK2Serine / threonine-protein kinase MARK2Serine / threonine-protein kinase MARK2CSNK1DCasein kinase I isoform deltaCasein kinase I isoform deltaAAK1AP2-associated protein kinase 1AP2-associated protein kinase 1IRAK3Interleukin-1 receptor-associated kinase 3Interleukin-1 receptor-associated kinase 3STAT3Signal transducer and activator of transcription 3Signal transducer and activator of transcription 3CAMKK1Calcium / calmodulin-dependent protein kinase kinase 1Calcium / calmodulin-dependent protein kinase kinase 1EEDPolycomb protein EEDPolycomb protein EEDCSNK1A1Casein kinase I isoform alphaCasein kinase I isoform alphaNEK1Serine / threonine-protein kinase Nek1Serine / threonine-protein kinase Nek1BMP2KBMP-2-inducible protein kinaseBMP-2-inducible protein kinaseMAPK7Mitogen-activated protein kinase 7Mitogen-activated protein kinase 7ULK1Serine / threonine-protein kinase ULK1Serine / threonine-protein kinase ULK1RPS6KA3Ribosomal protein S6 kinase alpha-3Ribosomal protein S6 kinase alpha-3PTPN11Tyrosine-protein phosphatase non-receptor type 11Tyrosine-protein phosphatase non-receptor type 11LIMK2LIM domain kinase 2LIM domain kinase 2CSNK1ECasein kinase I isoform epsilonCasein kinase I isoform epsilonEIF2AK4eIF-2-alpha kinase GCN2eIF-2-alpha kinase GCN2MAP2K5Dual specificity mitogen-activated protein kinase kinase 5Dual specificity mitogen-activated protein kinase kinase 5MAP4K3Mitogen-activated protein kinase kinase kinase kinase 3Mitogen-activated protein kinase kinase kinase kinase 3VHLvon Hippel-Lindau disease tumor suppressorvon Hippel-Lindau disease tumor suppressorMARK3MAP / microtubule affinity-regulating kinase 3MAP / microtubule affinity-regulating kinase 3TAOK2Serine / threonine-protein kinase TAO2Serine / threonine-protein kinase TAO2MAP4K5Mitogen-activated protein kinase kinase kinase kinase 5Mitogen-activated protein kinase kinase kinase kinase 5SNRKSNF-related serine / threonine-protein kinaseSNF-related serine / threonine-protein kinaseEEF2KEukaryotic elongation factor 2 kinaseEukaryotic elongation factor 2 kinaseSGK3Serine / threonine-protein kinase Sgk3Serine / threonine-protein kinase Sgk3AHRAryl hydrocarbon receptorAryl hydrocarbon receptorNEK4Serine / threonine-protein kinase Nek4Serine / threonine-protein kinase Nek4NEK9Serine / threonine-protein kinase Nek9Serine / threonine-protein kinase Nek9CITCitron Rho-interacting kinaseCitron Rho-interacting kinaseLATS1Serine / threonine-protein kinase LATS1Serine / threonine-protein kinase LATS1MINK1Misshapen-like kinase 1Misshapen-like kinase 1SIK3Serine / threonine-protein kinase SIK3Serine / threonine-protein kinase SIK3RPS6KA4Ribosomal protein S6 kinase alpha-4Ribosomal protein S6 kinase alpha-4NEK3Serine / threonine-protein kinase Nek3Serine / threonine-protein kinase Nek3SIK2Serine / threonine-protein kinase SIK2Serine / threonine-protein kinase SIK2MAST3Microtubule-associated serine / threonine-protein kinase 3Microtubule-associated serine / threonine-protein kinase 3STK32CSerine / threonine-protein kinase 32CSerine / threonine-protein kinase 32CALKALK tyrosine kinase receptorALK tyrosine kinase receptorALK2(activin receptor-like kinase 2,ALK2)(activin receptor-like kinase 2,ALK2)EPHB4Ephrin type-B receptor 4Ephrin type-B receptor 4PARP2Poly (ADP-ribose) polymerase 2Poly (ADP-ribose) polymerase 2PTK6Protein-tyrosine kinase 6Protein-tyrosine kinase 6PARP3Protein mono-ADP-ribosyltransferase PARP3Protein mono-ADP-ribosyltransferase PARP3CDK2Cyclin-dependent kinase 2Cyclin-dependent kinase 2CDK8Cyclin-dependent kinase 8Cyclin-dependent kinase 8BRDTBromodomain testis-specific proteinBromodomain testis-specific proteinMAPKAPK5MAP kinase-activated protein kinase 5MAP kinase-activated protein kinase 5MAP3K1Mitogen-activated protein kinase kinase kinase 1Mitogen-activated protein kinase kinase kinase 1CDK18Cyclin-dependent kinase 18Cyclin-dependent kinase 18CDK10Cyclin-dependent kinase 10Cyclin-dependent kinase 10TTKDual specificity protein kinase TTKDual specificity protein kinase TTKPIM2Serine / threonine-protein kinase pim-2Serine / threonine-protein kinase pim-2PKMYT1Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinaseMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinaseMKNK2MAP kinase-interacting serine / threonine-protein kinase 2MAP kinase-interacting serine / threonine-protein kinase 2KAT2BHistone acetyltransferase KAT2BHistone acetyltransferase KAT2BNEK2Serine / threonine-protein kinase Nek2Serine / threonine-protein kinase Nek2HASPINSerine / threonine-protein kinase haspinSerine / threonine-protein kinase haspinPIRPirinPirinCYP1B1Cytochrome P450 1B1Cytochrome P450 1B1ERN1Serine / threonine-protein kinase / endoribonuclease IRE1Serine / threonine-protein kinase / endoribonuclease IRE1MELKMaternal embryonic leucine zipper kinaseMaternal embryonic leucine zipper kinaseCOQ8AAtypical kinase COQ8A, mitochondrialAtypical kinase COQ8A, mitochondrialRIOK2Serine / threonine-protein kinase RI02Serine / threonine-protein kinase RI02RPS6KA6Ribosomal protein S6 kinase alpha-6Ribosomal protein S6 kinase alpha-6MAP3K20Mitogen-activated protein kinase kinase kinase 20Mitogen-activated protein kinase kinase kinase 20MAPKAPK3MAP kinase-activated protein kinase 3MAP kinase-activated protein kinase 3ULK3Serine / threonine-protein kinase ULK3Serine / threonine-protein kinase ULK3MAP3K21Mitogen-activated protein kinase kinase kinase 21Mitogen-activated protein kinase kinase kinase 21COQ8BAtypical kinase COQ8B, mitochondrialAtypical kinase COQ8B, mitochondrialTNK1Non-receptor tyrosine-protein kinase TNK1Non-receptor tyrosine-protein kinase TNK1BMPR1ABone morphogenetic protein receptor type-1ABone morphogenetic protein receptor type-1ASTK17ASerine / threonine-protein kinase 17ASerine / threonine-protein kinase 17ACDK11ACyclin-dependent kinase 11ACyclin-dependent kinase 11ATESK2Dual specificity testis-specific protein kinase 2Dual specificity testis-specific protein kinase 2NLKSerine / threonine-protein kinase NLKSerine / threonine-protein kinase NLKSTK35Serine / threonine-protein kinase 35Serine / threonine-protein kinase 35PKN3Serine / threonine-protein kinase N3Serine / threonine-protein kinase N3STK33Serine / threonine-protein kinase 33Serine / threonine-protein kinase 33SBK1Serine / threonine-protein kinase SBK1Serine / threonine-protein kinase SBK1SLC9A2Sodium / hydrogen exchanger 2Sodium / hydrogen exchanger 2CSNK2A3Casein kinase II subunit alpha 3Casein kinase II subunit alpha 3TACC3Transforming acidic coiled-coil-containing protein 3Transforming acidic coiled-coil-containing protein 3GSPT1Eukaryotic peptide chain release factor GTP-binding subunit ERF3AEukaryotic peptide chain release factor GTP-binding subunit ERF3ASLC9A7Sodium / hydrogen exchanger 7Sodium / hydrogen exchanger 7RPS6KC1Ribosomal protein S6 kinase delta-1Ribosomal protein S6 kinase delta-1TBCKTBC domain-containing protein kinase-like proteinTBC domain-containing protein kinase-like proteinCRABP1Cellular retinoic acid-binding protein 1Cellular retinoic acid-binding protein 1BCKDK[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrialTRPM7Transient receptor potential cation channel subfamily M member 7Transient receptor potential cation channel subfamily M member 7TRIB3Tribbles homolog 3Tribbles homolog 3UHMK1Serine / threonine-protein kinase KistSerine / threonine-protein kinase KistPDIK1LSerine / threonine-protein kinase PDIK1LSerine / threonine-protein kinase PDIK1LSTK40Serine / threonine-protein kinase 40Serine / threonine-protein kinase 40SLC9A4Sodium / hydrogen exchanger 4Sodium / hydrogen exchanger 4EPHB3Ephrin type-B receptor 3Ephrin type-B receptor 3NTRK3NT-3 growth factor receptorNT-3 growth factor receptorMAP3K12Mitogen-activated protein kinase kinase kinase 12Mitogen-activated protein kinase kinase kinase 12MAPK11Mitogen-activated protein kinase 11Mitogen-activated protein kinase 11DDR2Discoidin domain-containing receptor 2Discoidin domain-containing receptor 2RARBRetinoic acid receptor betaRetinoic acid receptor betaPDE4CcAMP-specific 3',5'-cyclic phosphodiesterase 4CcAMP-specific 3',5'-cyclic phosphodiesterase 4CIDO1Indoleamine 2,3-dioxygenase 1Indoleamine 2,3-dioxygenase 1SLC9B1Sodium / hydrogen exchanger 9B1Sodium / hydrogen exchanger 9B1PRAG1Inactive tyrosine-protein kinase PRAG1Inactive tyrosine-protein kinase PRAG1TOP 1DNA topoisomerase 1DNA topoisomerase 1TOP2ADNA topoisomerase 2-alphaDNA topoisomerase 2-alphaCXCR4C-X-C chemokine receptor type 4C-X-C chemokine receptor type 4ERBB4Receptor tyrosine-protein kinase erbB-4Receptor tyrosine-protein kinase erbB-4HCKTyrosine-protein kinase HCKTyrosine-protein kinase HCKSYKTyrosine-protein kinase SYKTyrosine-protein kinase SYKACLYATP-citrate synthaseATP-citrate synthaseIMPDH2Inosine-5'-monophosphate dehydrogenase 2Inosine-5'-monophosphate dehydrogenase 2CYP3A4Cytochrome P450 3A4Cytochrome P450 3A4TOP2BDNA topoisomerase 2-betaDNA topoisomerase 2-betaKEAP1Kelch-like ECH-associated protein 1Kelch-like ECH-associated protein 1NR3C1Glucocorticoid receptorGlucocorticoid receptorDNMT1DNA (cytosine-5)-methyltransferase 1DNA (cytosine-5)-methyltransferase 1TXNRD1Thioredoxin reductase 1, cytoplasmicThioredoxin reductase 1, cytoplasmicHDAC4Histone deacetylase 4Histone deacetylase 4PDGFRAPlatelet-derived growth factor receptor alphaPlatelet-derived growth factor receptor alphaTUBBTubulin beta chainTubulin beta chainTUBB2BTubulin beta-2B chainTubulin beta-2B chainGABRA5Gamma-aminobutyric acid receptor subunit alpha-5Gamma-aminobutyric acid receptor subunit alpha-5EPHB1Ephrin type-B receptor 1Ephrin type-B receptor 1KCNQ2Potassium voltage-gated channel subfamily KQT member 2Potassium voltage-gated channel subfamily KQT member 2GRIK2Glutamate receptor ionotropic, kainate 2Glutamate receptor ionotropic, kainate 2CALM1Calmodulin-1Calmodulin-1HDAC5Histone deacetylase 5Histone deacetylase 5DNMT3ADNA (cytosine-5)-methyltransferase 3ADNA (cytosine-5)-methyltransferase 3AKIF5BKinesin-1 heavy chainKinesin-1 heavy chainPOLD1DNA polymerase delta catalytic subunitDNA polymerase delta catalytic subunitCUL4ACullin-4ACullin-4ATUBB2ATubulin beta-2A chainTubulin beta-2A chainPDGFRBPlatelet-derived growth factor receptor betaPlatelet-derived growth factor receptor betaFGRTyrosine-protein kinase FgrTyrosine-protein kinase FgrPRKCGProtein kinase C gamma typeProtein kinase C gamma typeSCN3ASodium channel protein type 3 subunit alphaSodium channel protein type 3 subunit alphaHDAC9Histone deacetylase 9Histone deacetylase 9BACE1Beta-secretase 1Beta-secretase 1HSP90AA1Heat shock protein HSP 90-alphaHeat shock protein HSP 90-alphaHSP90AB1Heat shock protein HSP 90-betaHeat shock protein HSP 90-betaPDPK13-phosphoinositide-dependent protein kinase 13-phosphoinositide-dependent protein kinase 1BIRC2Baculoviral IAP repeat-containing protein 2Baculoviral IAP repeat-containing protein 2CHEK2Serine / threonine-protein kinase Chk2Serine / threonine-protein kinase Chk2MAP3K5Mitogen-activated protein kinase kinase kinase 5Mitogen-activated protein kinase kinase kinase 5CASP1Caspase-1Caspase-1NAE1NEDD8-activating enzyme E1 regulatory subunitNEDD8-activating enzyme E1 regulatory subunitPIK3R1Phosphatidylinositol 3-kinase regulatory subunit alphaPhosphatidylinositol 3-kinase regulatory subunit alphaIKBKBInhibitor of nuclear factor kappa-B kinase subunit betaInhibitor of nuclear factor kappa-B kinase subunit betaPSMA1Proteasome subunit alpha type-1Proteasome subunit alpha type-1ITGB1Integrin beta-1Integrin beta-1PRKDCDNA-dependent protein kinase catalytic subunitDNA-dependent protein kinase catalytic subunitPIK3R2Phosphatidylinositol 3-kinase regulatory subunit betaPhosphatidylinositol 3-kinase regulatory subunit betaFGF2Fibroblast growth factor 2Fibroblast growth factor 2ZAP70Tyrosine-protein kinase ZAP-70Tyrosine-protein kinase ZAP-70PIP4K2BPhosphatidylinositol 5-phosphate 4-kinase type-2 betaPhosphatidylinositol 5-phosphate 4-kinase type-2 betaGAPDHGlyceraldehyde-3-phosphate dehydrogenaseGlyceraldehyde-3-phosphate dehydrogenaseFASNFatty acid synthaseFatty acid synthasePKMPyruvate kinase PKMPyruvate kinase PKMVCPTransitional endoplasmic reticulum ATPaseTransitional endoplasmic reticulum ATPaseKDM1ALysine-specific histone demethylase 1ALysine-specific histone demethylase 1ATAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1EP300Histone acetyltransferase p300Histone acetyltransferase p300VRK1Serine / threonine-protein kinase VRK1Serine / threonine-protein kinase VRK1RPS6KA5Ribosomal protein S6 kinase alpha-5Ribosomal protein S6 kinase alpha-5UBA2SUMO-activating enzyme subunit 2SUMO-activating enzyme subunit 2LDHAL-lactate dehydrogenase A chainL-lactate dehydrogenase A chainTKTTransketolaseTransketolaseHPRT1Hypoxanthine-guanine phosphoribosyltransferaseHypoxanthine-guanine phosphoribosyltransferaseKDM2ALysine-specific demethylase 2ALysine-specific demethylase 2AEHMT1Histone-lysine N-methyltransferase EHMT1Histone-lysine N-methyltransferase EHMT1CAMK1DCalcium / calmodulin-dependent protein kinase type 1DCalcium / calmodulin-dependent protein kinase type 1DWDR5WD repeat-containing protein 5WD repeat-containing protein 5EHMT2Histone-lysine N-methyltransferase EHMT2Histone-lysine N-methyltransferase EHMT2RAC1Ras-related C3 botulinum toxin substrate 1Ras-related C3 botulinum toxin substrate 1OGTUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitNCOA1Nuclear receptor coactivator 1Nuclear receptor coactivator 1PHGDHD-3-phosphoglycerate dehydrogenaseD-3-phosphoglycerate dehydrogenaseARHGDIARho GDP-dissociation inhibitor 1Rho GDP-dissociation inhibitor 1RBBP4Histone-binding protein RBBP4Histone-binding protein RBBP4BPTFNucleosome-remodeling factor subunit BPTFNucleosome-remodeling factor subunit BPTFKAT5Histone acetyltransferase KAT5Histone acetyltransferase KAT5NOTCH1Neurogenic locus notch homolog protein 1Neurogenic locus notch homolog protein 1PPIAPeptidyl-prolyl cis-trans isomerase APeptidyl-prolyl cis-trans isomerase AFKBP4Peptidyl-prolyl cis-trans isomerase FKBP4Peptidyl-prolyl cis-trans isomerase FKBP4CREBBPCREB-binding proteinCREB-binding proteinPOLBDNA polymerase betaDNA polymerase betaAPEX1DNA-(apurinic or apyrimidinic site) endonucleaseDNA-(apurinic or apyrimidinic site) endonucleaseCCNT1Cyclin-T1Cyclin-T 1EIF4A1Eukaryotic initiation factor 4A-IEukaryotic initiation factor 4A-IUSP7Ubiquitin carboxyl-terminal hydrolase 7Ubiquitin carboxyl-terminal hydrolase 7CTNNB1Catenin beta-1Catenin beta-1TXNThioredoxinThioredoxinDDX3XATP-dependent RNA helicase DDX3XATP-dependent RNA helicase DDX3XNLRP3NACHT, LRR and PYD domains-containing protein 3NACHT, LRR and PYD domains-containing protein 3TNKSPoly [ADP-ribose] polymerase tankyrase-1Poly [ADP-ribose] polymerase tankyrase-1PAK3Serine / threonine-protein kinase PAK 3Serine / threonine-protein kinase PAK 3PKN1Serine / threonine-protein kinase N1Serine / threonine-protein kinase N1CISD1CDGSH iron-sulfur domain-containing protein 1CDGSH iron-sulfur domain-containing protein 1WNK1Serine / threonine-protein kinase WNK1Serine / threonine-protein kinase WNK1BRD1Bromodomain-containing protein 1Bromodomain-containing protein 1XIAPE3 ubiquitin-protein ligase XIAPE3 ubiquitin-protein ligase XIAPPRDX1Peroxiredoxin-1Peroxiredoxin-1KMT2AHistone-lysine N-methyltransferase 2AHistone-lysine N-methyltransferase 2AKDM5CLysine-specific demethylase 5CLysine-specific demethylase 5CRPA1Replication protein A 70 kDa DNA-binding subunitReplication protein A 70 kDa DNA-binding subunitCAMK1Calcium / calmodulin-dependent protein kinase type 1Calcium / calmodulin-dependent protein kinase type 1EIF4A3Eukaryotic initiation factor 4A-IIIEukaryotic initiation factor 4A-IIITAF1Transcription initiation factor TFIID subunit 1Transcription initiation factor TFIID subunit1ALKBH3Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3MAP3K2Mitogen-activated protein kinase kinase kinase 2Mitogen-activated protein kinase kinase kinase 2RELATranscription factor p65Transcription factor p65NCOR2Nuclear receptor corepressor 2Nuclear receptor corepressor 2PRPF4BSerine / threonine-protein kinase PRP4 homologSerine / threonine-protein kinase PRP4 homologRPS340S ribosomal protein S340S ribosomal protein S3RPSA40S ribosomal protein SA40S ribosomal protein SARPS27AUbiquitin-40S ribosomal protein S27aUbiquitin-40S ribosomal protein S27aRPS2040S ribosomal protein S2040S ribosomal protein S20RPL1860S ribosomal protein L1860S ribosomal protein L18RPS540S ribosomal protein S540S ribosomal protein S5RPL660S ribosomal protein L660S ribosomal protein L6RPLP060S acidic ribosomal protein P060S acidic ribosomal protein P0RPL360S ribosomal protein L360S ribosomal protein L3RPL18A60S ribosomal protein L18a60S ribosomal protein L18aRPL2860S ribosomal protein L2860S ribosomal protein L28RPL1960S ribosomal protein L1960S ribosomal protein L19RPL3460S ribosomal protein L3460S ribosomal protein L34RPS1340S ribosomal protein S1340S ribosomal protein S13RPL2460S ribosomal protein L2460S ribosomal protein L24RPS1540S ribosomal protein S1540S ribosomal protein S15RPL560S ribosomal protein L560S ribosomal protein L5RPS1040S ribosomal protein S1040S ribosomal protein S10RPL3560S ribosomal protein L3560S ribosomal protein L35RPS640S ribosomal protein S640S ribosomal protein S6RPS2440S ribosomal protein S2440S ribosomal protein S24RPS240S ribosomal protein S240S ribosomal protein S2RPL1160S ribosomal protein L1160S ribosomal protein L11RPS840S ribosomal protein S840S ribosomal protein S8RPL3260S ribosomal protein L3260S ribosomal protein L32RPS3A40S ribosomal protein S3a40S ribosomal protein S3aRPL1060S ribosomal protein L1060S ribosomal protein L10RPL7A60S ribosomal protein L7a60S ribosomal protein L7aRPL3060S ribosomal protein L3060S ribosomal protein L30RPL860S ribosomal protein L860S ribosomal protein L8RPL2660S ribosomal protein L2660S ribosomal protein L26RPS1440S ribosomal protein S1440S ribosomal protein S14RPL1360S ribosomal protein L1360S ribosomal protein L13RPS940S ribosomal protein S940S ribosomal protein S9RPS2140S ribosomal protein S2140S ribosomal protein S21RPS740S ribosomal protein S740S ribosomal protein S7RPL3860S ribosomal protein L3860S ribosomal protein L38RPL460S ribosomal protein L460S ribosomal protein L4RPL1560S ribosomal protein L1560S ribosomal protein L15RPS1740S ribosomal protein S1740S ribosomal protein S17RPS2340S ribosomal protein S2340S ribosomal protein S23RPL1460S ribosomal protein L1460S ribosomal protein L14RPL1260S ribosomal protein L1260S ribosomal protein L12RPS4X40S ribosomal protein S4, X isoform40S ribosomal protein S4, X isoformRPL23A60S ribosomal protein L23a60S ribosomal protein L23aRPL10A60S ribosomal protein L23a60S ribosomal protein L23aRPS1840S ribosomal protein S1840S ribosomal protein S18SLC7A5Large neutral amino acids transporter small subunit 1Large neutral amino acids transporter small subunit 1ORAI1Calcium release-activated calcium channel protein 1Calcium release-activated calcium channel protein 1PI4K2APhosphatidylinositol 4-kinase type 2-alphaPhosphatidylinositol 4-kinase type 2-alphaSUMO1Small ubiquitin-related modifier 1Small ubiquitin-related modifier 1HSPA8Heat shock cognate 71 kDa proteinHeat shock cognate 71 kDa proteinHSPD160 kDa heat shock protein, mitochondrial60 kDa heat shock protein, mitochondrialCSNK2BCasein kinase II subunit betaCasein kinase II subunit betaPPP2CASerine / threonine-protein phosphatase 2A catalytic subunit alpha isoformSerine / threonine-protein phosphatase 2A catalytic subunit alpha isoformFSCN1FascinFascinBIDBH3-interacting domain death agonistBH3-interacting domain death agonistDCUN1D1DCN1-like protein 1DCN1-like protein 1USP28Ubiquitin carboxyl-terminal hydrolase 28Ubiquitin carboxyl-terminal hydrolase 28TP53BP1TP53-binding protein 1TP53-binding protein 1KDM5ALysine-specific demethylase 5ALysine-specific demethylase 5ABAZ2ABromodomain adjacent to zinc finger domain protein 2ABromodomain adjacent to zinc finger domain protein 2AUBE2ISUMO-conjugating enzyme UBC9SUMO-conjugating enzyme UBC9SPIN1Spindlin-1Spindlin-1TDP2Tyrosyl-DNA phosphodiesterase 2Tyrosyl-DNA phosphodiesterase 2KDM5BLysine-specific demethylase 5BLysine-specific demethylase 5BRBBP5Retinoblastoma-binding protein 5Retinoblastoma-binding protein 5PRMT1Protein arginine N-methyltransferase 1Protein arginine N-methyltransferase 1MLLT1Protein ENLProtein ENLSETDB1Histone-lysine N-methyltransferase SETDB1Histone-lysine N-methyltransferase SETDB1ARNTAryl hydrocarbon receptor nuclear translocatorAryl hydrocarbon receptor nuclear translocatorSNRNP200U5 small nuclear ribonucleoprotein 200 kDa helicaseU5 small nuclear ribonucleoprotein 200 kDa helicaseATAD2ATPase family AAA domain-containing protein 2ATPase family AAA domain-containing protein 2SQSTM1Sequestosome-1Sequestosome-1DPY30Protein dpy-30 homologProtein dpy-30 homologWRNWerner syndrome ATP-dependent helicaseWerner syndrome ATP-dependent helicaseJMJD1CProbable JmjC domain-containing histone demethylation protein 2CProbable JmjC domain-containing histone demethylation protein 2CMDM4Protein Mdm4Protein Mdm4L3MBTL3Lethal(3)malignant brain tumor-like protein 3Lethal(3)malignant brain tumor-like protein 3LDLRLow-density lipoprotein receptorLow-density lipoprotein receptorGLULGlutamine synthetaseGlutamine synthetaseHRASGTPase HRasGTPase HRasAPOBEC3GDNA dC->dU-editing enzyme APOBEC-3GDNA dC->dU-editing enzyme APOBEC-3GTSG101Tumor susceptibility gene 101 proteinTumor susceptibility gene 101 proteinLRP6Low-density lipoprotein receptor-related protein 6Low-density lipoprotein receptor-related protein 6ENO1Alpha-enolaseAlpha-enolaseANXA2Annexin A2Annexin A2SOD1Superoxide dismutase [Cu-Zn]Superoxide dismutase [Cu-Zn]KAT6AHistone acetyltransferase KAT6AHistone acetyltransferase KAT6ACBSCystathionine beta-synthaseCystathionine beta-synthaseRUVBL1RuvB-like 1RuvB-like 1UHRF1E3 ubiquitin-protein ligase UHRF1E3 ubiquitin-protein ligase UHRF1HSPA5Endoplasmic reticulum chaperone BiPEndoplasmic reticulum chaperone BiPSQLESqualene monooxygenaseSqualene monooxygenaseNEDD4E3 ubiquitin-protein ligase NEDD4E3 ubiquitin-protein ligase NEDD4RBBP7Histone-binding protein RBBP7Histone-binding protein RBBP7UBE2NUbiquitin-conjugating enzyme E2 NUbiquitin-conjugating enzyme E2 NNRASGTPase NRasGTPase NRasPTENPhosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENPhosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENRHOATransforming protein RhoATransforming protein RhoARNF31E3 ubiquitin-protein ligase RNF31E3 ubiquitin-protein ligase RNF31PIN4Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4TPI1Triosephosphate isomeraseTriosephosphate isomerasePPIGPeptidyl-prolyl cis-trans isomerase GPeptidyl-prolyl cis-trans isomerase GNCOA2Nuclear receptor coactivator 2Nuclear receptor coactivator 2FOXO1Forkhead box protein O1Forkhead box protein O1PSIP1PC4 and SFRS1-interacting proteinPC4 and SFRS1-interacting proteinMACROD2ADP-ribose glycohydrolase MACROD2ADP-ribose glycohydrolase MACROD2SETD2Histone-lysine N-methyltransferase SETD2Histone-lysine N-methyltransferase SETD2NFKBIANF-kappa-B inhibitor alphaNF-kappa-B inhibitor alphaPLA2G4ACytosolic phospholipase A2Cytosolic phospholipase A2ICAM1Intercellular adhesion molecule 1Intercellular adhesion molecule 1ACVR1BActivin receptor type-1BActivin receptor type-1BCYBBCytochrome b-245 heavy chainCytochrome b-245 heavy chainSTAMBPSTAM-binding proteinSTAM-binding proteinNFKB1Nuclear factor NF-kappa-B p105 subunitNuclear factor NF-kappa-B p105 subunitPAK2Serine / threonine-protein kinase PAK 2Serine / threonine-protein kinase PAK 2ITPR1Inositol 1,4,5-trisphosphate receptor type 1Inositol 1,4,5-trisphosphate receptor type 1ELAVL1ELAV-like protein 1ELAV-like protein 1NFKB2Nuclear factor NF-kappa-B p100 subunitNuclear factor NF-kappa-B p100 subunitSTAT1Signal transducer and activator of transcription 1-alpha / betaSignal transducer and activator of transcription 1-alpha / betaSTATSASignal transducer and activator of transcription 5ASignal transducer and activator of transcription 5ARIPK3Receptor-interacting serine / threonine-protein kinase 3Receptor-interacting serine / threonine-protein kinase 3BRSK2Serine / threonine-protein kinase BRSK2Serine / threonine-protein kinase BRSK2ERCC4DNA repair endonuclease XPFDNA repair endonuclease XPFNPM1NucleophosminNucleophosminIKBKGNF-kappa-B essential modulatorNF-kappa-B essential modulatorPBKLymphokine-activated killer T-cell-originated protein kinaseLymphokine-activated killer T-cell-originated protein kinaseCD22B-cell receptor CD22B-cell receptor CD22APCAdenomatous polyposis coli proteinAdenomatous polyposis coli proteinPLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1ING2Inhibitor of growth protein 2Inhibitor of growth protein 2ERCC1DNA excision repair protein ERCC-1DNA excision repair protein ERCC-1KDM2BLysine-specific demethylase 2BLysine-specific demethylase 2BETV6Transcription factor ETV6Transcription factor ETV6CBX4E3 SUMO-protein ligase CBX4E3 SUMO-protein ligase CBX4USP25Ubiquitin carboxyl-terminal hydrolase 25Ubiquitin carboxyl-terminal hydrolase 25HSF1Heat shock factor protein 1Heat shock factor protein 1TRIM33E3 ubiquitin-protein ligase TRIM33E3 ubiquitin-protein ligase TRIM33HNRNPA1Heterogeneous nuclear ribonucleoprotein A1Heterogeneous nuclear ribonucleoprotein A1TERF2Telomeric repeat-binding factor 2Telomeric repeat-binding factor 2PTBP1Polypyrimidine tract-binding protein 1Polypyrimidine tract-binding protein 1NR2C2Nuclear receptor subfamily 2 group C member 2Nuclear receptor subfamily 2 group C member 2NOTCH2Neurogenic locus notch homolog protein 2Neurogenic locus notch homolog protein 2USP8Ubiquitin carboxyl-terminal hydrolase 8Ubiquitin carboxyl-terminal hydrolase 8RGS12Regulator of G-protein signaling 12Regulator of G-protein signaling 12ATF1Cyclic AMP-dependent transcription factor ATF-1Cyclic AMP-dependent transcription factor ATF-1PPM1BProtein phosphatase 1BProtein phosphatase 1BPDCD4Programmed cell death protein 4Programmed cell death protein 4LMNAPrelamin-A / CPrelamin-A / CMITFMicrophthalmia-associated transcription factorMicrophthalmia-associated transcription factorADCY3Adenylate cyclase type 3Adenylate cyclase type 3EEF1A1Elongation factor 1-alpha 1Elongation factor 1-alpha 1MYH9Myosin-9Myosin-9BCL3B-cell lymphoma 3 proteinB-cell lymphoma 3 proteinXRCCSX-ray repair cross-complementing protein 5X-ray repair cross-complementing protein 5USP4Ubiquitin carboxyl-terminal hydrolase 4Ubiquitin carboxyl-terminal hydrolase 4AGLGlycogen debranching enzymeGlycogen debranching enzymeXRCC6X-ray repair cross-complementing protein 6X-ray repair cross-complementing protein 6MAGI3Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3DVL1Segment polarity protein dishevelled homolog DVL-1Segment polarity protein dishevelled homolog DVL-1VDAC2Voltage-dependent anion-selective channel protein 2Voltage-dependent anion-selective channel protein 2MDH1Malate dehydrogenase, cytoplasmicMalate dehydrogenase, cytoplasmicCBX5Chromobox protein homolog 5Chromobox protein homolog 5USP10Ubiquitin carboxyl-terminal hydrolase 10Ubiquitin carboxyl-terminal hydrolase 10CBX1Chromobox protein homolog 1Chromobox protein homolog 1BRD8Bromodomain-containing protein 8Bromodomain-containing protein 8TSNAXTranslin-associated protein XTranslin-associated protein XCREB1Cyclic AMP-responsive element-binding protein 1Cyclic AMP-responsive element-binding protein 1RBCK1RanBP-type and C3HC4-type zinc finger-containing protein 1RanBP-type and C3HC4-type zinc finger-containing protein 1UBA1Ubiquitin-like modifier-activating enzyme 1Ubiquitin-like modifier-activating enzyme 1MACROD1ADP-ribose glycohydrolase MACROD1ADP-ribose glycohydrolase MACROD1PELP1Proline-, glutamic acid- and leucine-rich protein 1Proline-, glutamic acid- and leucine-rich protein 1BAP 1Ubiquitin carboxyl-terminal hydrolase BAP1Ubiquitin carboxyl-terminal hydrolase BAP1TERF2IPTelomeric repeat-binding factor 2-interacting protein 1Telomeric repeat-binding factor 2-interacting protein 1LARP7La-related protein 7La-related protein 7UBA7Ubiquitin-like modifier-activating enzyme 7Ubiquitin-like modifier-activating enzyme 7SUMO3Small ubiquitin-related modifier 3Small ubiquitin-related modifier 3SUMO2Small ubiquitin-related modifier 2Small ubiquitin-related modifier 2GIGYF2GRB10-interacting GYF protein 2GRB10-interacting GYF protein 2S100A10Protein S100-A10Protein S100-A10GRIK3Glutamate receptor ionotropic, kainate 3Glutamate receptor ionotropic, kainate 3TLR8Toll-like receptor 8Toll-like receptor 8DYRK2Dual specificity tyrosine-phosphorylation-regulated kinase 2Dual specificity tyrosine-phosphorylation-regulated kinase 2NOS1Nitric oxide synthase, brainNitric oxide synthase, brainWNK3Serine / threonine-protein kinase WNK3Serine / threonine-protein kinase WNK3TLR2Toll-like receptor 2Toll-like receptor 2BCL2L11Bcl-2-like protein 11Bcl-2-like protein 11SLC11A2Natural resistance-associated macrophage protein 2Natural resistance-associated macrophage protein 2ABCB11Bile salt export pumpBile salt export pumpITGALIntegrin alpha-LIntegrin alpha-LROCK1Rho-associated protein kinase 1Rho-associated protein kinase 1CA12Carbonic anhydrase 12Carbonic anhydrase 12EPHA7Ephrin type-A receptor 7Ephrin type-A receptor 7PRKCAProtein kinase C alpha typeProtein kinase C alpha typeCA2Carbonic anhydrase 2Carbonic anhydrase 2PDE2AcGMP-dependent 3',5'-cyclic phosphodiesterasecGMP-dependent 3',5'-cyclic phosphodiesteraseEPHA4Ephrin type-A receptor 4Ephrin type-A receptor 4ACEAngiotensin-converting enzymeAngiotensin-converting enzymeRAF1RAF proto-oncogene serine / threonine-protein kinaseRAF proto-oncogene serine / threonine-protein kinaseGLAAlpha-galactosidase AAlpha-galactosidase AMAOBAmine oxidase [flavin-containing] BAmine oxidase [flavin-containing] BAKR1B1Aldo-keto reductase family 1 member B1Aldo-keto reductase family 1 member B1GSRGlutathione reductase, mitochondrialGlutathione reductase, mitochondrialUMPSUridine 5'-monophosphate synthaseUridine 5'-monophosphate synthaseTHRAThyroid hormone receptor alphaThyroid hormone receptor alphaGARTTrifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine- -glycine ligaseTrifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligaseFDPSFarnesyl pyrophosphate synthaseFarnesyl pyrophosphate synthaseADH5Alcohol dehydrogenase class-3Alcohol dehydrogenase class-3RXRBRetinoic acid receptor RXR-betaRetinoic acid receptor RXR-betaDHFRDihydrofolate reductaseDihydrofolate reductasePDE10AcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AIDH1Isocitrate dehydrogenase [NADP] cytoplasmicIsocitrate dehydrogenase [NADP] cytoplasmicITGB2Integrin beta-2Integrin beta-2COMTCatechol O-methyltransferaseCatechol O-methyltransferasePRKCQProtein kinase C theta typeProtein kinase C theta typeIMPDH1Inosine-5'-monophosphate dehydrogenase 1Inosine-5'-monophosphate dehydrogenase 1HDAC7Histone deacetylase 7Histone deacetylase 7TUBB3Tubulin beta-3 chainTubulin beta-3 chainTUBA1ATubulin alpha-1A chainTubulin alpha-1A chainADAAdenosine deaminaseAdenosine deaminaseGABRG2Gamma-aminobutyric acid receptor subunit gamma-2Gamma-aminobutyric acid receptor subunit gamma-2GABBR2Gamma-aminobutyric acid type B receptor subunit 2Gamma-aminobutyric acid type B receptor subunit 2GABRB2Gamma-aminobutyric acid receptor subunit beta-2Gamma-aminobutyric acid receptor subunit beta-2GABRB3Gamma-aminobutyric acid receptor subunit beta-3Gamma-aminobutyric acid receptor subunit beta-3GABBR1Gamma-aminobutyric acid type B receptor subunit 1Gamma-aminobutyric acid type B receptor subunit 1PRKCEProtein kinase C epsilon typeProtein kinase C epsilon typeSIGMAR1Sigma non-opioid intracellular receptor 1Sigma non-opioid intracellular receptor 1MTORSerine / threonine-protein kinase mTORSerine / threonine-protein kinase mTORSLC29A1Equilibrative nucleoside transporter 1Equilibrative nucleoside transporter 1KCNJ11ATP-sensitive inward rectifier potassium channel 11ATP-sensitive inward rectifier potassium channel 11GAALysosomal alpha-glucosidaseLysosomal alpha-glucosidasePRKCHProtein kinase C eta typeProtein kinase C eta typePIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformROCK2Rho-associated protein kinase 2Rho-associated protein kinase 2MAOAAmine oxidase [flavin-containing] AAmine oxidase [flavin-containing] ASOAT1Sterol O-acyltransferase 1Sterol O-acyltransferase 1BCRBreakpoint cluster region proteinBreakpoint cluster region proteinPSMBSProteasome subunit beta type-5Proteasome subunit beta type-5XPO1Exportin-1Exportin-1MALT1Mucosa-associated lymphoid tissue lymphoma translocation protein 1Mucosa-associated lymphoid tissue lymphoma translocation protein 1IDH2Isocitrate dehydrogenase [NADP], mitochondrialIsocitrate dehydrogenase [NADP], mitochondrialRRM1Ribonucleoside-diphosphate reductase large subunitRibonucleoside-diphosphate reductase large subunitNDUFA10NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrialNADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrialEPHA5Ephrin type-A receptor 5Ephrin type-A receptor 5TUBB4BTubulin beta-4B chainTubulin beta-4B chainTUBB1Tubulin beta-1 chainTubulin beta-1 chainTUBB4ATubulin beta-4A chainTubulin beta-4A chainTUBB6Tubulin beta-6 chainTubulin beta-6 chainTUBA4ATubulin alpha-4A chainTubulin alpha-4A chainTUBA1CTubulin alpha-1C chainTubulin alpha-1C chainCACNB1Voltage-dependent L-type calcium channel subunit beta-1Voltage-dependent L-type calcium channel subunit beta-1ATP1A2Sodium / potassium-transporting ATPase subunit alpha-2Sodium / potassium-transporting ATPase subunit alpha-2ATP1A3Sodium / potassium-transporting ATPase subunit alpha-3Sodium / potassium-transporting ATPase subunit alpha-3GRIA1Glutamate receptor 1Glutamate receptor 1GABRB1Gamma-aminobutyric acid receptor subunit beta-1Gamma-aminobutyric acid receptor subunit beta-1ATP1A1Sodium / potassium-transporting ATPase subunit alpha-1Sodium / potassium-transporting ATPase subunit alpha-1KCNQ5Potassium voltage-gated channel subfamily KQT member 5Potassium voltage-gated channel subfamily KQT member 5PRKCDProtein kinase C delta typeProtein kinase C delta typeCACNAIHVoltage-dependent T-type calcium channel subunit alpha-1HVoltage-dependent T-type calcium channel subunit alpha-1HGRIA4Glutamate receptor 4Glutamate receptor 4KCNA3Potassium voltage-gated channel subfamily A member 3Potassium voltage-gated channel subfamily A member 3S1PR3Sphingosine 1-phosphate receptor 3Sphingosine 1-phosphate receptor 3NISCHNischarinNischarinPRKCBProtein kinase C beta typeProtein kinase C beta typeTLR7Toll-like receptor 7Toll-like receptor 7CACNA1BVoltage-dependent N-type calcium channel subunit alpha-1BVoltage-dependent N-type calcium channel subunit alpha-1BCACNA2D2Voltage-dependent calcium channel subunit alpha-2 / delta-2Voltage-dependent calcium channel subunit alpha-2 / delta-2CPT2Carnitine O-palmitoyltransferase 2, mitochondrialCarnitine O-palmitoyltransferase 2, mitochondrialFAAHFatty-acid amide hydrolase 1Fatty-acid amide hydrolase 1UGCGCeramide glucosyltransferaseCeramide glucosyltransferasePDE1ACalcium / calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1ACalcium / calmodulin-dependent 3',5' -cyclic nucleotide phosphodiesterase 1AHPD4-hydroxyphenylpyruvate dioxygenase4-hydroxyphenylpyruvate dioxygenaseCA5BCarbonic anhydrase 5B, mitochondrialCarbonic anhydrase 5B, mitochondrialCA5ACarbonic anhydrase 5A, mitochondrialCarbonic anhydrase 5A, mitochondrialANO1Anoctamin-1Anoctamin-1DHCR24Delta(24)-sterol reductaseDelta(24)-sterol reductaseCCDC6Coiled-coil domain-containing protein 6Coiled-coil domain-containing protein 6EML4Echinoderm microtubule-associated protein-like 4Echinoderm microtubule-associated protein-like 4KCNA2Potassium voltage-gated channel subfamily A member 2Potassium voltage-gated channel subfamily A member 2KCNB2Potassium voltage-gated channel subfamily B member 2Potassium voltage-gated channel subfamily B member 2PLA2G7Platelet-activating factor acetylhydrolasePlatelet-activating factor acetylhydrolaseGRM5Metabotropic glutamate receptor 5Metabotropic glutamate receptor 5PLA2G2APhospholipase A2, membrane associatedPhospholipase A2, membrane associatedMIFMacrophage migration inhibitory factorMacrophage migration inhibitory factorGBALysosomal acid glucosylceramidaseLysosomal acid glucosylceramidaseINSRInsulin receptorInsulin receptorGSTP1Glutathione S-transferase PGlutathione S-transferase PPNPPurine nucleoside phosphorylasePurine nucleoside phosphorylaseFDFT1Squalene synthaseSqualene synthaseCASP8Caspase-8Caspase-8CASP9Caspase-9Caspase-9CASP6Caspase-6Caspase-6CASP3Caspase-3Caspase-3CASP7Caspase-7Caspase-7ERAP1Endoplasmic reticulum aminopeptidase 1Endoplasmic reticulum aminopeptidase 1UBA3NEDD8-activating enzyme E1 catalytic subunitNEDDS-activating enzyme E1 catalytic subunitPSEN1Presenilin-1Presenilin-1FNTAProtein famesyltransferase / geranylgeranyltransferase type-1 subunit alphaProtein famesyltransferase / geranylgeranyltransferase type-1 subunit alphaMETAP1Methionine aminopeptidase 1Methionine aminopeptidase 1CASP2Caspase-2Caspase-2ITGA4Integrin alpha-4Integrin alpha-4ABCB1ATP-dependent translocase ABCB1ATP-dependent translocase ABCB1NTSR1Neurotensin receptor type 1Neurotensin receptor type 1GRM3Metabotropic glutamate receptor 3Metabotropic glutamate receptor 3LNPEPLeucyl-cystinyl aminopeptidaseLeucyl-cystinyl aminopeptidaseAPH1AGamma-secretase subunit APH-1AGamma-secretase subunit APH-1ANCSTNNicastrinNicastrinPSMB1Proteasome subunit beta type-1Proteasome subunit beta type-1PSMA2Proteasome subunit alpha type-2Proteasome subunit alpha type-2PSMB7Proteasome subunit beta type-7Proteasome subunit beta type-7PSMA5Proteasome subunit alpha type-5Proteasome subunit alpha type-5PSMA4Proteasome subunit alpha type-4Proteasome subunit alpha type-4PSMA3Proteasome subunit alpha type-3Proteasome subunit alpha type-3PSMA6Proteasome subunit alpha type-6Proteasome subunit alpha type-6PSMA7Proteasome subunit alpha type-7Proteasome subunit alpha type-7PSMB2Proteasome subunit beta type-2Proteasome subunit beta type-2EGLN1Egl nine homolog 1Egl nine homolog 1PSMB6Proteasome subunit beta type-6Proteasome subunit beta type-6PSMB4Proteasome subunit beta type-4Proteasome subunit beta type-4PSMB8Proteasome subunit beta type-8Proteasome subunit beta type-8PSMB10Proteasome subunit beta type-10Proteasome subunit beta type-10PSMB9Proteasome subunit beta type-9Proteasome subunit beta type-9FNTBProtein farnesyltransferase subunit betaProtein farnesyltransferase subunit betaPSMB3Proteasome subunit beta type-3Proteasome subunit beta type-3ERAP2Endoplasmic reticulum aminopeptidase 2Endoplasmic reticulum aminopeptidase 2DNPEPAspartyl aminopeptidaseAspartyl aminopeptidaseSTSSteryl-sulfataseSteryl-sulfataseSELLL-selectinL-selectinCCR1C-C chemokine receptor type 1C-C chemokine receptor type 1PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformPORCNProtein-serine O-palmitoleoyltransferase porcupineProtein-serine O-palmitoleoyltransferase porcupineP4HTMTransmembrane prolyl 4-hydroxylaseTransmembrane prolyl 4-hydroxylaseATRSerine / threonine-protein kinase ATRSerine / threonine-protein kinase ATRCDK19Cyclin-dependent kinase 19Cyclin-dependent kinase 19CDK3Cyclin-dependent kinase 3Cyclin-dependent kinase 3CASP4Caspase-4Caspase-4PIK3R5Phosphoinositide 3-kinase regulatory subunit 5Phosphoinositide 3-kinase regulatory subunit 5CASP10Caspase-10Caspase-10NPEPPSPuromycin-sensitive aminopeptidasePuromycin-sensitive aminopeptidaseRNPEPAminopeptidase BAminopeptidase BLAP3Cytosol aminopeptidaseCytosol aminopeptidaseCDK20Cyclin-dependent kinase 20Cyclin-dependent kinase 20DPYDDihydropyrimidine dehydrogenase [NADP(+)]Dihydropyrimidine dehydrogenase [NADP(+)]XPNPEP1Xaa-Pro aminopeptidase 1Xaa-Pro aminopeptidase 1NAMPTNicotinamide phosphoribosyltransferaseNicotinamide phosphoribosyltransferasePRKACAcAMP-dependent protein kinase catalytic subunit alphacAMP-dependent protein kinase catalytic subunit alphaPSMD1426S proteasome non-ATPase regulatory subunit 1426S proteasome non-ATPase regulatory subunit 14ARAFSerine / threonine-protein kinase A-RafSerine / threonine-protein kinase A-RafPRKACBcAMP-dependent protein kinase catalytic subunit betacAMP-dependent protein kinase catalytic subunit betaITGAVIntegrin alpha-VIntegrin alpha-VTGM2Protein-glutamine gamma-glutamyltransferase 2Protein-glutamine gamma-glutamyltransferase 2ACE2Angiotensin-converting enzyme 2Angiotensin-converting enzyme 2PAK1Serine / threonine-protein kinase PAK 1Serine / threonine-protein kinase PAK 1CAPN1Calpain-1 catalytic subunitCalpain-1 catalytic subunitCDC42Cell division control protein 42 homologCell division control protein 42 homologNMT1Glycylpeptide N-tetradecanoyltransferase 1Glycylpeptide N-tetradecanoyltransferase 1CAMK2DCalcium / calmodulin-dependent protein kinase type II subunit deltaCalcium / calmodulin-dependent protein kinase type II subunit deltaAKR1B10Aldo-keto reductase family 1 member B10Aldo-keto reductase family 1 member B10P4HBProtein disulfide-isomeraseProtein disulfide-isomeraseCDC42BPBSerine / threonine-protein kinase MRCK betaSerine / threonine-protein kinase MRCK betaCAMK2GCalcium / calmodulin-dependent protein kinase type II subunit gammaCalcium / calmodulin-dependent protein kinase type II subunit gammaPTP4A1Protein tyrosine phosphatase type IVA 1Protein tyrosine phosphatase type IVA 1G6PDGlucose-6-phosphate 1-dehydrogenaseGlucose-6-phosphate 1-dehydrogenaseLSSLanosterol synthaseLanosterol synthaseALBAlbuminAlbuminECE1Endothelin-converting enzyme 1Endothelin-converting enzyme 1CTSDCathepsin DCathepsin DCTSBCathepsin BCathepsin BILKIntegrin-linked protein kinaseIntegrin-linked protein kinaseMGLLMonoglyceride lipaseMonoglyceride lipaseCASKPeripheral plasma membrane protein CASKPeripheral plasma membrane protein CASKADAM17Disintegrin and metalloproteinase domain-containing protein 17Disintegrin and metalloproteinase domain-containing protein 17PYGLGlycogen phosphorylase, liver formGlycogen phosphorylase, liver formATICBifunctional purine biosynthesis protein ATICBifunctional purine biosynthesis protein ATICHSD17B103-hydroxyacyl-CoA dehydrogenase type-23-hydroxyacyl-CoA dehydrogenase type-2SRPK1SRSF protein kinase 1SRSF protein kinase 1LTA4HLeukotriene A-4 hydrolaseLeukotriene A-4 hydrolaseSTK16Serine / threonine-protein kinase 16Serine / threonine-protein kinase 16ADKAdenosine kinaseAdenosine kinaseGRK6G protein-coupled receptor kinase 6G protein-coupled receptor kinase 6ACVR1Activin receptor type-1Activin receptor type-1CES1Liver carboxylesterase 1Liver carboxylesterase 1CSNK1G3Casein kinase I isoform gamma-3Casein kinase I isoform gamma-3CYP51A1Lanosterol 14-alpha demethylaseLanosterol 14-alpha demethylaseCAMK2ACalcium / calmodulin-dependent protein kinase type II subunit alphaCalcium / calmodulin-dependent protein kinase type II subunit alphaBCAT1Branched-chain-amino-acid aminotransferase, cytosolicBranched-chain-amino -acid aminotransferase, cytosolicMAP2K4Dual specificity mitogen-activated protein kinase kinase 4Dual specificity mitogen-activated protein kinase kinase 4ACACBAcetyl-CoA carboxylase 2Acetyl-CoA carboxylase 2MTAPS-methyl-5'-thioadenosine phosphorylaseS-methyl-5'-thioadenosine phosphorylaseAHCYAdenosylhomocysteinaseAdenosylhomocysteinaseSTK24Serine / threonine-protein kinase 24Serine / threonine-protein kinase 24GALK1GalactokinaseGalactokinaseMAP2K6Dual specificity mitogen-activated protein kinase kinase 6Dual specificity mitogen-activated protein kinase kinase 6DCPSm7GpppX diphosphatasem7GpppX diphosphataseLDHBL-lactate dehydrogenase B chainL-lactate dehydrogenase B chainEPHX2Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2Bifunctional epoxide hydrolase 2 [Includes: Cytosolic epoxide hydrolase 2NQO2Ribosyldihydronicotinamide dehydrogenase [quinone]Ribosyldihydronicotinamide dehydrogenase [quinone]SRPK2SRSF protein kinase 2SRSF protein kinase 2SAE1SUMO-activating enzyme subunit 1SUMO-activating enzyme subunit 1CARM1Histone-arginine methyltransferase CARM1Histone-arginine methyltransferase CARM1CAMK4Calcium / calmodulin-dependent protein kinase type IVCalcium / calmodulin-dependent protein kinase type IVTNIKTRAF2 and NCK-interacting protein kinaseTRAF2 and NCK-interacting protein kinaseDCKDeoxycytidine kinaseDeoxycytidine kinasePHKG2Phosphorylase b kinase gamma catalytic chain, liver / testis isoformPhosphorylase b kinase gamma catalytic chain, liver / testis isoformDYRK1ADual specificity tyrosine-phosphorylation-regulated kinase 1ADual specificity tyrosine-phosphorylation-regulated kinase 1ACBR1Carbonyl reductase [NADPH] 1Carbonyl reductase [NADPH] 1DAPK3Death-associated protein kinase 3Death-associated protein kinase 3FEN1Flap endonuclease 1Flap endonuclease 1OXSR1Serine / threonine-protein kinase OSR1Serine / threonine-protein kinase OSR1CLK3Dual specificity protein kinase CLK3Dual specificity protein kinase CLK3UPP1Uridine phosphorylase 1Uridine phosphorylase 1AKR1C1Aldo-keto reductase family 1 member C1Aldo-keto reductase family 1 member C1AKR1C3Aldo-keto reductase family 1 member C3Aldo-keto reductase family 1 member C3CD38ADP-ribosyl cyclase / cyclic ADP-ribose hydrolase 1ADP-ribosyl cyclase / cyclic ADP-ribose hydrolase 1SORT1SortilinSortilinGALNT2Polypeptide N-acetylgalactosaminyltransferase 2Polypeptide N-acetylgalactosaminyltransferase 2LGALS1Galectin-1Galectin-1HK2Hexokinase-2Hexokinase-2HK1Hexokinase-1Hexokinase-1HMOX1Heme oxygenase 1Heme oxygenase 1PARP14Protein mono-ADP-ribosyltransferase PARP14Protein mono-ADP-ribosyltransferase PARP14GRB2Growth factor receptor-bound protein 2Growth factor receptor-bound protein 2HMOX2Heme oxygenase 2Heme oxygenase 2DDAH1N(G),N(G)-dimethylarginine dimethylaminohydrolase 1N(G),N(G)-dimethylarginine dimethylaminohydrolase 1PARP12Protein mono-ADP-ribosyltransferase PARP12Protein mono-ADP-ribosyltransferase PARP12OATOrnithine aminotransferase, mitochondrialOrnithine aminotransferase, mitochondrialSIRT6NAD-dependent protein deacetylase sirtuin-6NAD-dependent protein deacetylase sirtuin-6PGK1Phosphoglycerate kinase 1Phosphoglycerate kinase 1KAT8Histone acetyltransferase KAT8Histone acetyltransferase KAT8SPRSepiapterin reductaseSepiapterin reductaseCTHCystathionine gamma-lyaseCystathionine gamma-lyaseSIRT5NAD-dependent protein deacylase sirtuin-5, mitochondrialNAD-dependent protein deacylase sirtuin-5, mitochondrialGSTO1Glutathione S-transferase omega-1Glutathione S-transferase omega-1PFKFB36-phosphofructo-2-kinase / fructose-2,6-bisphosphatase 36-phosphofructo-2-kinase / fructose-2,6-bisphosphatase 3CTBP2C-terminal-binding protein 2C-terminal-binding protein 2PARP10Protein mono-ADP-ribosyltransferase PARP 10Protein mono-ADP-ribosyltransferase PARP 10SMYD3Histone-lysine N-methyltransferase SMYD3Histone-lysine N-methyltransferase SMYD3SULT1A1Sulfotransferase 1A1Sulfotransferase 1A1AKR1C4Aldo-keto reductase family 1 member C4Aldo-keto reductase family 1 member C4GSTM2Glutathione S-transferase Mu 2Glutathione S-transferase Mu 2STRADASTE20-related kinase adapter protein alphaSTE20-related kinase adapter protein alphaBMPR2Bone morphogenetic protein receptor type-2Bone morphogenetic protein receptor type-2PIK3C2APhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alphaPhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alphaPTPN1Tyrosine-protein phosphatase non-receptor type 1Tyrosine-protein phosphatase non-receptor type 1IDEInsulin-degrading enzymeInsulin-degrading enzymeCAPNS1Calpain small subunit 1Calpain small subunit 1GLO1Lactoylglutathione lyaseLactoylglutathione lyaseUCHL1Ubiquitin carboxyl-terminal hydrolase isozyme L1Ubiquitin carboxyl-terminal hydrolase isozyme L1NPC1NPC intracellular cholesterol transporter 1NPC intracellular cholesterol transporter 1FESTyrosine-protein kinase Fes / FpsTyrosine-protein kinase Fes / FpsCSNK1G1Casein kinase I isoform gamma-1Casein kinase I isoform gamma-1SLKSTE20-like serine / threonine-protein kinaseSTE20-like serine / threonine-protein kinaseMAP2K7Dual specificity mitogen-activated protein kinase kinase 7Dual specificity mitogen-activated protein kinase kinase 7PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3Phosphatidylinositol 3-kinase catalytic subunit type 3HAO1Hydroxyacid oxidase 1Hydroxyacid oxidase 1PASKPAS domain-containing serine / threonine-protein kinasePAS domain-containing serine / threonine-protein kinaseSTK25Serine / threonine-protein kinase 25Serine / threonine-protein kinase 25KYNUKynureninaseKynureninaseDUTDeoxyuridine 5'-triphosphateDeoxyuridine 5'-triphosphatenucleotidohydrolase, mitochondrialnucleotidohydrolase, mitochondrialPTPN22Tyrosine-protein phosphatase non-receptor type 22Tyrosine-protein phosphatase non-receptor type 22NEK7Serine / threonine-protein kinase Nek7Serine / threonine-protein kinase Nek7NNMTNicotinamide N-methyltransferaseNicotinamide N-methyltransferaseNRP1Neuropilin-1Neuropilin-1RPS2740S ribosomal protein S2740S ribosomal protein S27DDR1Epithelial discoidin domain-containing receptor 1Epithelial discoidin domain-containing receptor 1LPLLipoprotein lipaseLipoprotein lipaseABCC1Multidrug resistance-associated protein 1Multidrug resistance-associated protein 1ASIC1Acid-sensing ion channel 1Acid-sensing ion channel 1SLC2A1Solute carrier family 2, facilitated glucose transporter member 1Solute carrier family 2, facilitated glucose transporter member 1PTPRSReceptor-type tyrosine-protein phosphatase SReceptor-type tyrosine-protein phosphatase SABCG2Broad substrate specificity ATP-binding cassette transporter ABCG2Broad substrate specificity ATP-binding cassette transporter ABCG2SLC1A3Excitatory amino acid transporter 1Excitatory amino acid transporter 1SLC1A1Excitatory amino acid transporter 3Excitatory amino acid transporter 3TRPM2Transient receptor potential cation channel subfamily M member 2Transient receptor potential cation channel subfamily M member 2GRM1Metabotropic glutamate receptor 1Metabotropic glutamate receptor 1MLKLMixed lineage kinase domain-like proteinMixed lineage kinase domain-like proteinRAB7ARas-related protein Rab-7aRas-related protein Rab-7aAHCYL1S-adenosylhomocysteine hydrolase-like protein 1S-adenosylhomocysteine hydrolase-like protein 1NAAAN-acylethanolamine-hydrolyzing acid amidaseN-acylethanolamine-hydrolyzing acid amidaseCAMK2BCalcium / calmodulin-dependent protein kinase type II subunit betaCalcium / calmodulin-dependent protein kinase type II subunit betaNT5E5'-nucleotidase5'-nucleotidaseCTSLProcathepsin LProcathepsin LHSPA1AHeat shock 70 kDa protein 1AHeat shock 70 kDa protein 1AFABPSFatty acid-binding protein 5Fatty acid-binding protein 5CTSCDipeptidyl peptidase 1Dipeptidyl peptidase 1ACVR2AActivin receptor type-2AActivin receptor type-2AMMP14Matrix metalloproteinase-14Matrix metalloproteinase-14HSP90B1EndoplasminEndoplasminGLB1Beta-galactosidaseBeta-galactosidasePTPRFReceptor-type tyrosine-protein phosphatase FReceptor-type tyrosine-protein phosphatase FST14Suppressor of tumorigenicity 14 proteinSuppressor of tumorigenicity 14 proteinPKN2Serine / threonine-protein kinase N2Serine / threonine-protein kinase N2ARG1Arginase-1Arginase-1PGAM1Phosphoglycerate mutase 1Phosphoglycerate mutase 1PPPICASerine / threonine-protein phosphatase PP1-alpha catalytic subunitSerine / threonine-protein phosphatase PP1-alpha catalytic subunitPTP4A2Protein tyrosine phosphatase type IVA 2Protein tyrosine phosphatase type IVA 2MAST1Microtubule-associated serine / threonine-protein kinase 1Microtubule-associated serine / threonine-protein kinase 1PI4KBPhosphatidylinositol 4-kinase betaPhosphatidylinositol 4-kinase betaVRK2Serine / threonine-protein kinase VRK2Serine / threonine-protein kinase VRK2SCDStearoyl-CoA desaturaseStearoyl-CoA desaturaseNUDT17,8-dihydro-8-oxoguanine triphosphatase7,8-dihydro-8-oxoguanine triphosphataseCSNK1G2Casein kinase I isoform gamma-2Casein kinase I isoform gamma-2EBP3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase3-beta-hydroxysteroid-Delta(8),Delta(7)-isomeraseEIF2AK3Eukaryotic translation initiation factor 2-alpha kinase 3Eukaryotic translation initiation factor 2-alpha kinase 3ATP2A2Sarcoplasmic / endoplasmic reticulum calcium ATPase 2Sarcoplasmic / endoplasmic reticulum calcium ATPase 2MAN1B1Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidaseEndoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidaseCDKLSCyclin-dependent kinase-like 5Cyclin-dependent kinase-like 5MAP4K4Mitogen-activated protein kinase kinase kinase kinase 4Mitogen-activated protein kinase kinase kinase kinase 4DPP8Dipeptidyl peptidase 8Dipeptidyl peptidase 8MKNK1MAP kinase-interacting serine / threonine-protein kinase 1MAP kinase-interacting serine / threonine-protein kinase 1PREPProlyl endopeptidaseProlyl endopeptidaseFKBPSPeptidyl-prolyl cis-trans isomerase FKBPSPeptidyl-prolyl cis-trans isomerase FKBPSSIRT1NAD-dependent protein deacetylase sirtuin-1NAD-dependent protein deacetylase sirtuin-1STK3Serine / threonine-protein kinase 3Serine / threonine-protein kinase 3LIG1DNA ligase 1DNA ligase 1DUSP3Dual specificity protein phosphatase 3Dual specificity protein phosphatase 3CAMKK2Calcium / calmodulin-dependent protein kinase kinase 2Calcium / calmodulin-dependent protein kinase kinase 2PRKAB15'-AMP-activated protein kinase subunit beta-15'-AMP-activated protein kinase subunit beta-1MTRMethionine synthaseMethionine synthaseUCHL3Ubiquitin carboxyl-terminal hydrolase isozyme L3Ubiquitin carboxyl-terminal hydrolase isozyme L3ESRRBSteroid hormone receptor ERR2Steroid hormone receptor ERR2RIOK1Serine / threonine-protein kinase RIO1Serine / threonine-protein kinase RIO1TRAP1Heat shock protein 75 kDa, mitochondrialHeat shock protein 75 kDa, mitochondrialPIN1Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1ALDH1A2Retinal dehydrogenase 2Retinal dehydrogenase 2PAK6Serine / threonine-protein kinase PAK 6Serine / threonine-protein kinase PAK 6AOX1Aldehyde oxidaseAldehyde oxidaseDPP9Dipeptidyl peptidase 9Dipeptidyl peptidase 9ACP1Low molecular weight phosphotyrosine protein phosphataseLow molecular weight phosphotyrosine protein phosphatasePTPN7Tyrosine-protein phosphatase non-receptor type 7Tyrosine-protein phosphatase non-receptor type 7TLK2Serine / threonine-protein kinase tousled-like 2Serine / threonine-protein kinase tousled-like 2SMG1Serine / threonine-protein kinase SMG1Serine / threonine-protein kinase SMG1YWHAZ14-3-3 protein zeta / delta14-3-3 protein zeta / deltaALDH1A1Retinal dehydrogenase 1Retinal dehydrogenase 1PHF8Histone lysine demethylase PHF8Histone lysine demethylase PHF8PRKAG15'-AMP-activated protein kinase subunit gamma-15'-AMP-activated protein kinase subunit gamma-1PRMT3Protein arginine N-methyltransferase 3Protein arginine N-methyltransferase 3SF3B3Splicing factor 3B subunit 3Splicing factor 3B subunit 3AKT1S1Proline-rich AKT1 substrate 1Proline-rich AKT1 substrate 1CHUKInhibitor of nuclear factor kappa-B kinase subunit alphaInhibitor of nuclear factor kappa-B kinase subunit alphaRPL36A60S ribosomal protein L36a60S ribosomal protein L36aRPL3160S ribosomal protein L3160S ribosomal protein L31RPS1640S ribosomal protein S1640S ribosomal protein S16RPS1940S ribosomal protein S1940S ribosomal protein S19RPS1240S ribosomal protein S1240S ribosomal protein S12RPL2260S ribosomal protein L2260S ribosomal protein L22RPS2540S ribosomal protein S2540S ribosomal protein S25RPL2160S ribosomal protein L2160S ribosomal protein L21RPL2360S ribosomal protein L2360S ribosomal protein L23RPS4Y140S ribosomal protein S4, Y isoform 140S ribosomal protein S4, Y isoform 1RPL3660S ribosomal protein L3660S ribosomal protein L36RPL2760S ribosomal protein L2760S ribosomal protein L27RPS15A40S ribosomal protein S15a40S ribosomal protein S15aRPS1140S ribosomal protein S1140S ribosomal protein S11RPL13A60S ribosomal protein L13a60S ribosomal protein L13aRPL3760S ribosomal protein L3760S ribosomal protein L37RPL760S ribosomal protein L760S ribosomal protein L7RPL2960S ribosomal protein L2960S ribosomal protein L29RPL27A60S ribosomal protein L27a60S ribosomal protein L27aRPL35A60S ribosomal protein L35a60S ribosomal protein L35aRPS2640S ribosomal protein S2640S ribosomal protein S26RPL37A60S ribosomal protein L37a60S ribosomal protein L37aRPS2940S ribosomal protein S2940S ribosomal protein S29RPS2840S ribosomal protein S2840S ribosomal protein S28RPL1760S ribosomal protein L1760S ribosomal protein L17FAU40S ribosomal protein S3040S ribosomal protein S30SLC2A3Solute carrier family 2, facilitated glucose transporter member 3Solute carrier family 2, facilitated glucose transporter member 3ASAH1Acid ceramidaseAcid ceramidaseBTN3A1Butyrophilin subfamily 3 member A1Butyrophilin subfamily 3 member A1NMT2Glycylpeptide N-tetradecanoyltransferase 2Glycylpeptide N-tetradecanoyltransferase 2PI4KAPhosphatidylinositol 4-kinase alphaPhosphatidylinositol 4-kinase alphaGNG2Guanine nucleotide-binding protein G(I) / G(S) / G(O) subunit gamma-2Guanine nucleotide-binding protein G(I) / G(S) / G(O) subunit gamma-2GNA11Guanine nucleotide-binding protein subunit alpha-11Guanine nucleotide-binding protein subunit alpha-11PRMT8Protein arginine N-methyltransferase 8Protein arginine N-methyltransferase 8LYPLA1Acyl-protein thioesterase 1Acyl-protein thioesterase 1LGALS3Galectin-3Galectin-3UBE2D3Ubiquitin-conjugating enzyme E2 D3Ubiquitin-conjugating enzyme E2 D3S100A4Protein S100-A4Protein S100-A4LGALS9Galectin-9Galectin-9PIP4K2APhosphatidylinositol 5-phosphate 4-kinase type-2 alphaPhosphatidylinositol 5-phosphate 4-kinase type-2 alphaLGMNLegumainLegumainGNB1Guanine nucleotide-binding protein G(I) / G(S) / G(T) subunit beta-1Guanine nucleotide-binding protein G(I) / G(S) / G(T) subunit beta-1HINT1Histidine triad nucleotide-binding protein 1Histidine triad nucleotide-binding protein 1FTOAlpha-ketoglutarate-dependent dioxygenase FTOAlpha-ketoglutarate-dependent dioxygenase FTOBRPF1PeregrinPeregrinST6GAL1Beta-galactoside alpha-2,6-sialyltransferase 1Beta-galactoside alpha-2,6-sialyltransferase 1INPPL1Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2PI4K2BPhosphatidylinositol 4-kinase type 2-betaPhosphatidylinositol 4-kinase type 2-betaPARP16Protein mono-ADP-ribosyltransferase PARP 16Protein mono-ADP-ribosyltransferase PARP16HEXABeta-hexosaminidase subunit alphaBeta-hexosaminidase subunit alphaSGPL1Sphingosine-1-phosphate lyase 1Sphingosine-1-phosphate lyase 1MGAT2Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferaseAlpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferaseLGALS8Galectin-8Galectin-8ASH2LSet1 / Ash2 histone methyltransferase complex subunit ASH2Set1 / Ash2 histone methyltransferase complex subunit ASH2SARM1NAD(+) hydrolase SARM1NAD(+) hydrolase SARM1LYPLA2Acyl-protein thioesterase 2Acyl-protein thioesterase 2ASNSAsparagine synthetase [glutamine-hydrolyzing]Asparagine synthetase [glutamine-hydrolyzing]PABPC1Polyadenylate-binding protein 1Polyadenylate-binding protein 1PRMTSProtein arginine N-methyltransferase 5Protein arginine N-methyltransferase 5DNPH12'-deoxynucleoside 5'-phosphate N-hydrolase 12'-deoxynucleoside 5'-phosphate N-hydrolase 1WDR48WD repeat-containing protein 48WD repeat-containing protein 48WDR77Methylosome protein 50Methylosome protein 50ATAD2BATPase family AAA domain-containing protein 2BATPase family AAA domain-containing protein 2BCOPSSCOP9 signalosome complex subunit 5COP9 signalosome complex subunit 5PFKFB26-phosphofructo-2-kinase / fructose-2,6-bisphosphatase 26-phosphofructo-2-kinase / fructose-2,6-bisphosphatase 2KDM4BLysine-specific demethylase 4BLysine-specific demethylase 4BPRKAB25'-AMP-activated protein kinase subunit beta-25'-AMP-activated protein kinase subunit beta-2MEN1MeninMeninPMM2Phosphomannomutase 2Phosphomannomutase 2RPTORRegulatory-associated protein of mTORRegulatory-associated protein of mTORMLST8Target of rapamycin complex subunit LST8Target of rapamycin complex subunit LST8DTYMKThymidylate kinaseThymidylate kinasePTPN9Tyrosine-protein phosphatase non-receptor type 9Tyrosine-protein phosphatase non-receptor type 9SHMT2Serine hydroxymethyltransferase, mitochondrialSerine hydroxymethyltransferase, mitochondrialPARGPoly(ADP-ribose) glycohydrolasePoly(ADP-ribose) glycohydrolaseGLSGlutaminase kidney isoform, mitochondrialGlutaminase kidney isoform, mitochondrialAPAF1Apoptotic protease-activating factor 1Apoptotic protease-activating factor 1KSR2Kinase suppressor of Ras 2Kinase suppressor of Ras 2SORDSorbitol dehydrogenaseSorbitol dehydrogenaseSMSSpermine synthaseSpermine synthaseGALEUDP-glucose 4-epimeraseUDP-glucose 4-epimerasePGD6-phosphogluconate dehydrogenase, decarboxylating6-phosphogluconate dehydrogenase, decarboxylatingHNMTHistamine N-methyltransferaseHistamine N-methyltransferaseQDPRDihydropteridine reductaseDihydropteridine reductaseGSTK1Glutathione S-transferase kappa 1Glutathione S-transferase kappa 1SRMSpermidine synthaseSpermidine synthaseFARS2Phenylalanine--tRNA ligase, mitochondrialPhenylalanine--tRNA ligase, mitochondrialGNAI3Guanine nucleotide-binding protein G(i) subunit alpha-3Guanine nucleotide-binding protein G(i) subunit alpha-3CLTCClathrin heavy chain 1Clathrin heavy chain 1RHOCRho-related GTP-binding protein RhoCRho-related GTP-binding protein RhoCDNM1Dynamin-1Dynamin-1GALNT10Polypeptide N-acetylgalactosaminyltransferase 10Polypeptide N-acetylgalactosaminyltransferase 10MTHFD1C-1-tetrahydrofolate synthase, cytoplasmicC-1-tetrahydrofolate synthase, cytoplasmicRAB2ARas-related protein Rab-2ARas-related protein Rab-2AUSP5Ubiquitin carboxyl-terminal hydrolase 5Ubiquitin carboxyl-terminal hydrolase 5GDAGuanine deaminaseGuanine deaminaseUCK2Uridine-cytidine kinase 2Uridine-cytidine kinase 2HIF1ANHypoxia-inducible factor 1-alpha inhibitorHypoxia-inducible factor 1-alpha inhibitorMDH2Malate dehydrogenase, mitochondrialMalate dehydrogenase, mitochondrialCYP2E1Cytochrome P450 2E1Cytochrome P450 2E1YWHAG14-3-3 protein gamma14-3-3 protein gammaGFPT1Glutamine-fructose-6-phosphate aminotransferase [isomerizing] 1Glutamine-fructose-6-phosphate aminotransferase [isomerizing] 1FN1FibronectinFibronectinPLAURUrokinase plasminogen activator surface receptorUrokinase plasminogen activator surface receptorNCS1Neuronal calcium sensor 1Neuronal calcium sensor 1GNAI1Guanine nucleotide-binding protein G(i) subunit alpha-1Guanine nucleotide-binding protein G(i) subunit alpha-1HCN2Potassium / sodium hyperpolarization-activated cyclic nucleotide-gated channel 2Potassium / sodium hyperpolarization-activated cyclic nucleotide-gated channel 2QSOX1Sulfhydryl oxidase 1Sulfhydryl oxidase 1TLR1Toll-like receptor 1Toll-like receptor 1USP14Ubiquitin carboxyl-terminal hydrolase 14Ubiquitin carboxyl-terminal hydrolase 14KSR1Kinase suppressor of Ras 1Kinase suppressor of Ras 1RAB9ARas-related protein Rab-9ARas-related protein Rab-9ACCR7C-C chemokine receptor type 7C-C chemokine receptor type 7PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2GFERFAD-linked sulfhydryl oxidase ALRFAD-linked sulfhydryl oxidase ALRPTPRGReceptor-type tyrosine-protein phosphatase gammaReceptor-type tyrosine-protein phosphatase gammaFUT8Alpha-(1,6)-fucosyltransferaseAlpha-(1,6)-fucosyltransferasePORNADPH-cytochrome P450 reductaseNADPH-cytochrome P450 reductaseRECQLATP-dependent DNA helicase Q1ATP-dependent DNA helicase Q1UNGUracil-DNA glycosylaseUracil-DNA glycosylaseCADCAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthaseCAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthaseNCOA3Nuclear receptor coactivator 3Nuclear receptor coactivator 3CTDSP1Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1KDM1BLysine-specific histone demethylase 1BLysine-specific histone demethylase 1BTEAD1Transcriptional enhancer factor TEF-1Transcriptional enhancer factor TEF-1DDOD-aspartate oxidaseD-aspartate oxidaseCD4T-cell surface glycoprotein CD4T-cell surface glycoprotein CD4SLC1A5Neutral amino acid transporter B(0)Neutral amino acid transporter B(0)CD81CD81 antigenCD81 antigenGGT1Glutathione hydrolase 1 proenzymeGlutathione hydrolase 1 proenzymeADIPOR1Adiponectin receptor protein 1Adiponectin receptor protein 1RAP1ARas-related protein Rap-1ARas-related protein Rap-1ARAB29Ras-related protein Rab-7L1Ras-related protein Rab-7L1GOPCGolgi-associated PDZ and coiled-coil motif-containing proteinGolgi-associated PDZ and coiled-coil motif-containing proteinUTRNUtrophinUtrophinGNAO1Guanine nucleotide-binding protein G(o) subunit alphaGuanine nucleotide-binding protein G(o) subunit alphaDDOSTDolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunitDolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunitPYGBGlycogen phosphorylase, brain formGlycogen phosphorylase, brain formRABGGTBGeranylgeranyl transferase type-2 subunit betaGeranylgeranyl transferase type-2 subunit betaVAV1Proto-oncogene vavProto-oncogene vavSDHASuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialQTRT1Queuine tRNA-ribosyltransferase catalytic subunit 1Queuine tRNA-ribosyltransferase catalytic subunit 1CISD2CDGSH iron-sulfur domain-containing protein 2CDGSH iron-sulfur domain-containing protein 2DHPSDeoxyhypusine synthaseDeoxyhypusine synthasePPP2R5ASerine / threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoformSerine / threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoformPANK2Pantothenate kinase 2, mitochondrialPantothenate kinase 2, mitochondrialNEDD8NEDD8NEDD8DOHHDeoxyhypusine hydroxylaseDeoxyhypusine hydroxylaseUBE2MNEDD8-conjugating enzyme Ubc12NEDD8-conjugating enzyme Ubc12RNASEL2-5A-dependent ribonuclease2-5A-dependent ribonucleaseSYNJ1Synaptoj anin-1Synaptoj anin-1DUS2tRNA-dihydrouridine(20) synthase [NAD(P)+]-liketRNA-dihydrouridine(20) synthase [NAD(P)+]-likeCYCSCytochrome cCytochrome cPPP1CCSerine / threonine-protein phosphatase PP1-gamma catalytic subunitSerine / threonine-protein phosphatase PP1-gamma catalytic subunitHMBSPorphobilinogen deaminasePorphobilinogen deaminasePNPOPyridoxine-5'-phosphate oxidasePyridoxine-5'-phosphate oxidasePPIFPeptidyl-prolyl cis-trans isomerase F, mitochondrialPeptidyl-prolyl cis-trans isomerase F, mitochondrialDPP7Dipeptidyl peptidase 2Dipeptidyl peptidase 2MARK1Serine / threonine-protein kinase MARK1Serine / threonine-protein kinase MARK1PRCPLysosomal Pro-X carboxypeptidaseLysosomal Pro-X carboxypeptidasePIP4K2CPhosphatidylinositol 5-phosphate 4-kinase type-2 gammaPhosphatidylinositol 5-phosphate 4-kinase type-2 gammaAKR1A1Aldo-keto reductase family 1 member A1Aldo-keto reductase family 1 member A1ME1NADP-dependent malic enzymeNADP-dependent malic enzymeACACAAcetyl-CoA carboxylase 1Acetyl-CoA carboxylase 1CD74HLA class II histocompatibility antigen gamma chainHLA class II histocompatibility antigen gamma chainNFATC1Nuclear factor of activated T-cells, cytoplasmic 1Nuclear factor of activated T-cells, cytoplasmic 1RUNX1Runt-related transcription factor 1Runt-related transcription factor 1PTPRCReceptor-type tyrosine-protein phosphatase CReceptor-type tyrosine-protein phosphatase CCAPN2Calpain-2 catalytic subunitCalpain-2 catalytic subunitRB1Retinoblastoma-associated proteinRetinoblastoma-associated proteinITGA5Integrin alpha-5Integrin alpha-5ITGA2Integrin alpha-2Integrin alpha-2ADAM10Disintegrin and metalloproteinase domain-containing protein 10Disintegrin and metalloproteinase domain-containing protein 10DAGLBDiacylglycerol lipase-betaDiacylglycerol lipase-betaSLC16A1Monocarboxylate transporter 1Monocarboxylate transporter 1ABCC2ATP-binding cassette sub-family C member 2ATP-binding cassette sub-family C member 2SCARB1Scavenger receptor class B member 1Scavenger receptor class B member 1DAGLADiacylglycerol lipase-alphaDiacylglycerol lipase-alphaSLC47A1Multidrug and toxin extrusion protein 1Multidrug and toxin extrusion protein 1PIK3C2BPhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit betaPhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit betaGBA2Non-lysosomal glucosylceramidaseNon-lysosomal glucosylceramidaseNCEH1Neutral cholesterol ester hydrolase 1Neutral cholesterol ester hydrolase 1WNK2Serine / threonine-protein kinase WNK2Serine / threonine-protein kinase WNK2LIPEHormone-sensitive lipaseHormone-sensitive lipaseSLC27A1Long-chain fatty acid transport protein 1Long-chain fatty acid transport protein 1PTPRAReceptor-type tyrosine-protein phosphataseReceptor-type tyrosine-protein phosphatasealphaalphaPTPN2Tyrosine-protein phosphatase non-receptor type 2Tyrosine-protein phosphatase non-receptor type 2ITGB5Integrin beta-5Integrin beta-5CTSHPro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin HPro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin HMAN2B1Lysosomal alpha-mannosidaseLysosomal alpha-mannosidaseITPR2Inositol 1,4,5-trisphosphate receptor type 2Inositol 1,4,5-trisphosphate receptor type 2ITPR3Inositol 1,4,5-trisphosphate receptor type 3Inositol 1,4,5-trisphosphate receptor type 3ABHD12Lysophosphatidylserine lipase ABHD12Lysophosphatidylserine lipase ABHD12CTSZCathepsin ZCathepsin ZSLC6A12Sodium- and chloride-dependent betaine transporterSodium- and chloride-dependent betaine transporterSLC6A11Sodium- and chloride-dependent GABA transporter 3Sodium- and chloride-dependent GABA transporter 3KCNN3Small conductance calcium-activated potassium channel protein 3Small conductance calcium-activated potassium channel protein 3SLC27A4Long-chain fatty acid transport protein 4Long-chain fatty acid transport protein 4PTPN6Tyrosine-protein phosphatase non-receptor type 6Tyrosine-protein phosphatase non-receptor type 6AMPD3AMP deaminase 3AMP deaminase 3PLECPlectinPlectinPLD1Phospholipase D1Phospholipase D1PAMPeptidyl-glycine alpha-amidating monooxygenasePeptidyl-glycine alpha-amidating monooxygenasePRKD2Serine / threonine-protein kinase D2Serine / threonine-protein kinase D2TYROSTyrosine-protein kinase receptor TYROSTyrosine-protein kinase receptor TYROSRYR2Ryanodine receptor 2Ryanodine receptor 2PIP5K1CPhosphatidylinositol 4-phosphate 5-kinase type-1 gammaPhosphatidylinositol 4-phosphate 5-kinase type-1 gammaLIPALysosomal acid lipase / cholesteryl ester hydrolaseLysosomal acid lipase / cholesteryl ester hydrolasePPIBPeptidyl-prolyl cis-trans isomerase BPeptidyl-prolyl cis-trans isomerase BATP2A3Sarcoplasmic / endoplasmic reticulum calcium ATPase 3Sarcoplasmic / endoplasmic reticulum calcium ATPase 3CPT1ACarnitine O-palmitoyltransferase 1, liver isoformCarnitine O-palmitoyltransferase 1, liver isoformICMTProtein-S-isoprenylcysteine O-methyltransferaseProtein-S-isoprenylcysteine O-methyltransferaseHSD17B73-keto-steroid reductase / 17-beta-hydroxysteroid dehydrogenase 73-keto-steroid reductase / 17-beta-hydroxysteroid dehydrogenase 7ELOVL6Elongation of very long chain fatty acids protein 6Elongation of very long chain fatty acids protein 6DHCR77-dehydrocholesterol reductase7-dehydrocholesterol reductaseATP2A1Sarcoplasmic / endoplasmic reticulum calcium ATPase 1Sarcoplasmic / endoplasmic reticulum calcium ATPase 1RIOK3Serine / threonine-protein kinase RI03Serine / threonine-protein kinase RI03HSPB1Heat shock protein beta-1Heat shock protein beta-1PTPN12Tyrosine-protein phosphatase non-receptor type 12Tyrosine-protein phosphatase non-receptor type 12PLAAPhospholipase A-2-activating proteinPhospholipase A-2-activating proteinMPIMannose-6-phosphate isomeraseMannose-6-phosphate isomeraseMATKMegakaryocyte-associated tyrosine-protein kinaseMegakaryocyte-associated tyrosine-protein kinaseUBA6Ubiquitin-like modifier-activating enzyme 6Ubiquitin-like modifier-activating enzyme 6MAP2K3Dual specificity mitogen-activated protein kinase kinase 3Dual specificity mitogen-activated protein kinase kinase 3RPS6KA2Ribosomal protein S6 kinase alpha-2Ribosomal protein S6 kinase alpha-2MAP3K4Mitogen-activated protein kinase kinase kinase 4Mitogen-activated protein kinase kinase kinase 4PARP4Protein mono-ADP-ribosyltransferase PARP4Protein mono-ADP-ribosyltransferase PARP4EIF4HEukaryotic translation initiation factor 4HEukaryotic translation initiation factor 4HTESK1Dual specificity testis-specific protein kinase 1Dual specificity testis-specific protein kinase 1MLXMax-like protein XMax-like protein XNEK6Serine / threonine-protein kinase Nek6Serine / threonine-protein kinase Nek6ALDH1B1Aldehyde dehydrogenase X, mitochondrialAldehyde dehydrogenase X, mitochondrialATMSerine-protein kinase ATMSerine-protein kinase ATMCDYLChromodomain Y-like proteinChromodomain Y-like proteinTAOK1Serine / threonine-protein kinase TAO1Serine / threonine-protein kinase TAO1STAT6Signal transducer and activator of transcription 6Signal transducer and activator of transcription 6MGMTMethylated-DNA--protein-cysteine methyltransferaseMethylated-DNA--protein-cysteine methyltransferasePPIDPeptidyl-prolyl cis-trans isomerase DPeptidyl-prolyl cis-trans isomerase DSTATSBSignal transducer and activator of transcription 5BSignal transducer and activator of transcription 5BTXNRD2Thioredoxin reductase 2, mitochondrialThioredoxin reductase 2, mitochondrialTXNRD3Thioredoxin reductase 3Thioredoxin reductase 3STK39STE20 / SPS1-related proline-alanine-rich protein kinaseSTE20 / SPS1-related proline-alanine-rich protein kinaseSTK38LSerine / threonine-protein kinase 38-likeSerine / threonine-protein kinase 38-likeCDC42BPASerine / threonine-protein kinase MRCK alphaSerine / threonine-protein kinase MRCK alphaATG4BCysteine protease ATG4BCysteine protease ATG4BDCLK2Serine / threonine-protein kinase DCLK2Serine / threonine-protein kinase DCLK2TUBAL3Tubulin alpha chain-like 3Tubulin alpha chain-like 3MAP3K3Mitogen-activated protein kinase kinase kinase 3Mitogen-activated protein kinase kinase kinase 3PPME1Protein phosphatase methylesterase 1Protein phosphatase methylesterase 1RPLP160S acidic ribosomal protein P160S acidic ribosomal protein P1GSDMDGasdermin-DGasdermin-DC9Complement component C9 [Cleaved into: Complement component C9a; Complement component C9b]Complement component C9 [Cleaved into: Complement component C9a; Complement component C9b]HMGB1High mobility group protein B1High mobility group protein B 1DAB2IPDisabled homolog 2-interacting proteinDisabled homolog 2-interacting proteinPHLPP1PH domain leucine-rich repeat-containing protein phosphatase 1PH domain leucine-rich repeat-containing protein phosphatase 1PHKA2Phosphorylase b kinase regulatory subunit alpha, liver isoformPhosphorylase b kinase regulatory subunit alpha, liver isoformPHKA1Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoformPhosphorylase b kinase regulatory subunit alpha, skeletal muscle isoformPHKBPhosphorylase b kinase regulatory subunit betaPhosphorylase b kinase regulatory subunit betaEWSR1RNA-binding protein EWSRNA-binding protein EWSSLC16A3Monocarboxylate transporter 4Monocarboxylate transporter 4PTPREReceptor-type tyrosine-protein phosphatase epsilonReceptor-type tyrosine-protein phosphatase epsilonNEU1Sialidase-1Sialidase-1PCSK6Proprotein convertase subtilisin / kexin type 6Proprotein convertase subtilisin / kexin type 6ANTXR2Anthrax toxin receptor 2Anthrax toxin receptor 2STIM1Stromal interaction molecule 1Stromal interaction molecule 1DNM2Dynamin-2Dynamin-2SDHBSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialMAPKAP1Target of rapamycin complex 2 subunit MAPKAP1Target of rapamycin complex 2 subunit MAPKAP1PTGES2Prostaglandin E synthase 2Prostaglandin E synthase 2TMEM97Sigma intracellular receptor 2Sigma intracellular receptor 2SPPL2ASignal peptide peptidase-like 2ASignal peptide peptidase-like 2ASLC7A11Cystine / glutamate transporterCystine / glutamate transporterABHD6Monoacylglycerol lipase ABHD6Monoacylglycerol lipase ABHD6DGKADiacylglycerol kinase alphaDiacylglycerol kinase alphaNAPRTNicotinate phosphoribosyltransferaseNicotinate phosphoribosyltransferaseBAXApoptosis regulator BAXApoptosis regulator BAXSPTLC1Serine palmitoyltransferase 1Serine palmitoyltransferase 1SPTLC2Serine palmitoyltransferase 2Serine palmitoyltransferase 2MGAT1Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferaseAlpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferaseEPHX1Epoxide hydrolase 1Epoxide hydrolase 1FADS1Acyl-CoAAcyl-CoAABHDS1-acylglycerol-3-phosphate O-acyltransferase ABHDS1-acylglycerol-3-phosphate O-acyltransferase ABHDSCBFBCore-binding factor subunit betaCore-binding factor subunit betaPOLR1ADNA-directed RNA polymerase I subunit RPA1DNA-directed RNA polymerase I subunit RPA1MPGDNA-3-methyladenine glycosylaseDNA-3-methyladenine glycosylaseGYS1Glycogen [starch] synthase, muscleGlycogen [starch] synthase, musclePRKAG25'-AMP-activated protein kinase subunit gamma-25'-AMP-activated protein kinase subunit gamma-2ASF1AHistone chaperone ASF1AHistone chaperone ASF1AMED23Mediator of RNA polymerase II transcription subunit 23Mediator of RNA polymerase II transcription subunit 23PFKFB46-phosphofructo-2-kinase / fructose-2,6-bisphosphatase 46-phosphofructo-2-kinase / fructose-2,6-bisphosphatase 4KDM3ALysine-specific demethylase 3ALysine-specific demethylase 3AUSP9XProbable ubiquitin carboxyl-terminal hydrolase FAF-XProbable ubiquitin carboxyl-terminal hydrolase FAF-XMAXProtein maxProtein maxMBD2Methyl-CpG-binding domain protein 2Methyl-CpG-binding domain protein 2CBX8Chromobox protein homolog 8Chromobox protein homolog 8FLI1Friend leukemia integration 1 transcription factorFriend leukemia integration 1 transcription factorATRIPATR-interacting proteinATR-interacting proteinRICTORRapamycin-insensitive companion of mTORRapamycin-insensitive companion of mTORUBLCP1Ubiquitin-like domain-containing CTD phosphatase 1Ubiquitin-like domain-containing CTD phosphatase 1DCTPP1dCTP pyrophosphatase 1dCTP pyrophosphatase 1TCF4Transcription factor 4Transcription factor 4CNOT7CCR4-NOT transcription complex subunit 7CCR4-NOT transcription complex subunit 7OGFRL1Opioid growth factor receptor-like protein 1Opioid growth factor receptor-like protein 1MVDDiphosphomevalonate decarboxylaseDiphosphomevalonate decarboxylaseIL6STInterleukin-6 receptor subunit betaInterleukin-6 receptor subunit betaDOCK2Dedicator of cytokinesis protein 2Dedicator of cytokinesis protein 2C3Complement C3Complement C3PPM1AProtein phosphatase 1AProtein phosphatase 1ASHC1SHC-transforming protein 1SHC-transforming protein 1DVL2Segment polarity protein dishevelled homolog DVL-2Segment polarity protein dishevelled homolog DVL-2NPR3Atrial natriuretic peptide receptor 3Atrial natriuretic peptide receptor 3GSTM1Glutathione S-transferase Mu 1Glutathione S-transferase Mu 1PPP3CASerine / threonine-protein phosphatase 2B catalytic subunit alpha isoformSerine / threonine-protein phosphatase 2B catalytic subunit alpha isoformSLC12A2Solute carrier family 12 member 2Solute carrier family 12 member 2ABCC3ATP-binding cassette sub-family C member 3ATP-binding cassette sub-family C member 3ABCC4ATP-binding cassette sub-family C member 4ATP-binding cassette sub-family C member 4GGHGamma-glutamyl hydrolaseGamma-glutamyl hydrolaseHCN3Potassium / sodium hyperpolarization-activated cyclic nucleotide-gated channel 3Potassium / sodium hyperpolarization-activated cyclic nucleotide-gated channel 3ADCY1Adenylate cyclase type 1Adenylate cyclase type 1ADCY5Adenylate cyclase type 5Adenylate cyclase type 5CYP4F2Cytochrome P450 4F2Cytochrome P450 4F2HKDC1Hexokinase HKDC1Hexokinase HKDC 1PPT1Palmitoyl-protein thioesterase 1Palmitoyl-protein thioesterase 1PRNPMajor prion proteinMajor prion proteinCXCRSC-X-C chemokine receptor type 5C-X-C chemokine receptor type 5SMPD2Sphingomyelin phosphodiesterase 2Sphingomyelin phosphodiesterase 2SLC6A15Sodium-dependent neutral amino acid transporter B(0)AT2Sodium-dependent neutral amino acid transporter B(0)AT2MANBABeta-mannosidaseBeta-mannosidaseAGPAT21-acyl-sn-glycerol-3-phosphate acyltransferase beta1-acyl-sn-glycerol-3-phosphate acyltransferase betaABHD16APhosphatidylserine lipase ABHD16APhosphatidylserine lipase ABHD16AGCLCGlutamate-cysteine ligase catalytic subunitGlutamate-cysteine ligase catalytic subunitHAGHHydroxyacylglutathione hydrolase, mitochondrialHydroxyacylglutathione hydrolase, mitochondrialSENP1Sentrin-specific protease 1Sentrin-specific protease 1DNAJA1DnaJ homolog subfamily A member 1DnaJ homolog subfamily A member 1SCP2Sterol carrier protein 2Sterol carrier protein 2AMPD2AMP deaminase 2AMP deaminase 2ERCC5DNA repair protein complementing XP-G cellsDNA repair protein complementing XP-G cellsSENP7Sentrin-specific protease 7Sentrin-specific protease 7RBPJRecombining binding protein suppressor of hairlessRecombining binding protein suppressor of hairlessUSP47Ubiquitin carboxyl-terminal hydrolase 47Ubiquitin carboxyl-terminal hydrolase 47NADKNAD kinaseNAD kinaseRBBP9Serine hydrolase RBBP9Serine hydrolase RBBP9CD2T-cell surface antigen CD2T-cell surface antigen CD2CD44CD44 antigenCD44 antigenSLC27A2Very long-chain acyl-CoA synthetaseVery long-chain acyl-CoA synthetasePLEKHA1Pleckstrin homology domain-containing family A member 1Pleckstrin homology domain-containing family A member 1ITGA3Integrin alpha-3Integrin alpha-3CD47Leukocyte surface antigen CD47Leukocyte surface antigen CD47SPPL2BSignal peptide peptidase-like 2BSignal peptide peptidase-like 2BPLTPPhospholipid transfer proteinPhospholipid transfer proteinCD63CD63 antigenCD63 antigenSLC20A2Sodium-dependent phosphate transporter 2Sodium-dependent phosphate transporter 2ADCY6Adenylate cyclase type 6Adenylate cyclase type 6IGF2RCation-independent mannose-6-phosphate receptorCation-independent mannose-6-phosphate receptorEZREzrinEzrinGNAQGuanine nucleotide-binding protein G(q) subunit alphaGuanine nucleotide-binding protein G(q) subunit alphaINPP5AInositol polyphosphate-5-phosphatase AInositol polyphosphate-5-phosphatase ACRACR2AEF-hand calcium-binding domain-containing protein 4BEF-hand calcium-binding domain-containing protein 4BLANCL2LanC-like protein 2LanC-like protein 2SMPD3Sphingomyelin phosphodiesterase 3Sphingomyelin phosphodiesterase 3EHD1EH domain-containing protein 1EH domain-containing protein 1PDIA6Protein disulfide-isomerase A6Protein disulfide-isomerase A6CHN2Beta-chimaerinBeta-chimaerinCDH2Cadherin-2Cadherin-2TFPITissue factor pathway inhibitorTissue factor pathway inhibitorCD58Lymphocyte function-associated antigen 3Lymphocyte function-associated antigen 3SLC2A8Solute carrier family 2, facilitated glucose transporter member 8Solute carrier family 2, facilitated glucose transporter member 8PTPRMReceptor-type tyrosine-protein phosphatase muReceptor-type tyrosine-protein phosphatase muSTIM2Stromal interaction molecule 2Stromal interaction molecule 2ADCY7Adenylate cyclase type 7Adenylate cyclase type 7SLC20A1Sodium-dependent phosphate transporter 1Sodium-dependent phosphate transporter 1ITGA1Integrin alpha-1Integrin alpha-1RABGGTAGeranylgeranyl transferase type-2 subunit alphaGeranylgeranyl transferase type-2 subunit alphaMAP1BMicrotubule-associated protein 1BMicrotubule-associated protein 1BPAFAH1B2Platelet-activating factor acetylhydrolase IB subunit alpha2Platelet-activating factor acetylhydrolase IB subunit alpha2RIN1Ras and Rab interactor 1Ras and Rab interactor 1PLCD11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1RGS19Regulator of G-protein signaling 19Regulator of G-protein signaling 19PNPLA2Patatin-like phospholipase domain-containing protein 2Patatin-like phospholipase domain-containing protein 2ST3GAL3CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferaseCMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferaseGALNT1Polypeptide N-acetylgalactosaminyltransferase 1Polypeptide N-acetylgalactosaminyltransferase 1ATP6V1B2V-type proton ATPase subunit B, brain isoformV-type proton ATPase subunit B, brain isoformATP6AP1V-type proton ATPase subunit S1V-type proton ATPase subunit S1PHLPP2PH domain leucine-rich repeat-containing protein phosphatase 2PH domain leucine-rich repeat-containing protein phosphatase 2GNPATDihydroxyacetone phosphate acyltransferaseDihydroxyacetone phosphate acyltransferasePPP3CBSerine / threonine-protein phosphatase 2B catalytic subunit beta isoformSerine / threonine-protein phosphatase 2B catalytic subunit beta isoformSLC25A20Mitochondrial carnitine / acylcarnitine carrier proteinMitochondrial carnitine / acylcarnitine carrier proteinELOVL1Elongation of very long chain fatty acids protein 1Elongation of very long chain fatty acids protein 1MAN2A1Alpha-mannosidase 2Alpha-mannosidase 2SLC33A1Acetyl-coenzyme A transporter 1Acetyl-coenzyme A transporter 1GAB1GRB2-associated-binding protein 1GRB2-associated-binding protein 1ARHGEF12Rho guanine nucleotide exchange factor 12Rho guanine nucleotide exchange factor 12MAP2Microtubule-associated protein 2Microtubule-associated protein 2MBTD1MBT domain-containing protein 1MBT domain-containing protein 1PNKPBifunctional polynucleotide phosphatase / kinaseBifunctional polynucleotide phosphatase / kinaseNLRP1NACHT, LRR and PYD domains-containing protein 1NACHT, LRR and PYD domains-containing protein 1TXN2Thioredoxin, mitochondrialThioredoxin, mitochondrialEEF1A2Elongation factor 1-alpha 2Elongation factor 1-alpha 2GOT1Aspartate aminotransferase, cytoplasmicAspartate aminotransferase, cytoplasmicPRMT7Protein arginine N-methyltransferase 7Protein arginine N-methyltransferase 7MYH10Myosin-10Myosin-10TPP2Tripeptidyl-peptidase 2Tripeptidyl-peptidase 2EYA3Eyes absent homolog 3Eyes absent homolog 3SSU72RNA polymerase II subunit A C-terminal domain phosphatase SSU72RNA polymerase II subunit A C-terminal domain phosphatase SSU72AMDHD2N-acetylglucosamine-6-phosphate deacetylaseN-acetylglucosamine-6-phosphate deacetylaseCLPXATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrialATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrialMECP2Methyl-CpG-binding protein 2Methyl-CpG-binding protein 2KPNA2Importin subunit alpha-1Importin subunit alpha-1PSMG1Proteasome assembly chaperone 1Proteasome assembly chaperone 1CBX6Chromobox protein homolog 6Chromobox protein homolog 6PPP2R2ASerine / threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoformSerine / threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoformUBE2V1Ubiquitin-conjugating enzyme E2 variant 1Ubiquitin-conjugating enzyme E2 variant 1PSMG2Proteasome assembly chaperone 2Proteasome assembly chaperone 2PPICPeptidyl-prolyl cis-trans isomerase CPeptidyl-prolyl cis-trans isomerase CPGK2Phosphoglycerate kinase 2Phosphoglycerate kinase 2SOS1SOS Ras / Rac guanine nucleotide exchange factor 1SOS Ras / Rac guanine nucleotide exchange factor 1

[0066] In some embodiments, the PBM-R f - can be a small molecule ligand that targets and binds to specific target proteins, including but not limited to, epidermal growth factor receptor (EGFR), Cyclin-dependent kinase 4 / 6 (CDK4 / 6), anaplastic lymphoma kinase (ALK), activin receptor-like kinase 2 (ALK2), fibroblast growth factor receptors (FGFRs), proto-oncogene tyrosine-protein kinase receptor RET (RET), Focal adhesion kinase (FAK), breakpoint cluster region (BCR)-Abelson leukemia virus (ABL) (BCR-ABL) tyrosine kinase, Bruton tyrosine kinase (BTK), Androgen receptor (AR), Estrogen receptor (ER), Bromodomain and extra-terminal domain protein (BET), Interleukin-1 receptor-associated kinase 4 (IRAK4), Cyclin-dependent kinase 9 (CDK9), Histone-lysine N-methyltransferase EZH2 (EZH2), neurotrophic receptor tyrosine kinase (NTRK), Src homology 2 domain containing protein tyrosine phosphatase (SHP2), Poly (ADP-ribose) polymerase (PARP), signal transducers and activators of transcription 3 (STAT3), FMS-like tyrosine kinase 3 (FLT3), B cell lymphoma-2 (BCL-2) family proteins, SOS Ras / Rac guanine nucleotide exchange factor 1 (SOS1), or GTPase Kras (KRAS).

[0067] In some embodiments, PBM comprises the structures of the following formula: or wherein (R 1< ) p1 indicates that the benzene ring in Formula (PBM-1) is substituted with p1 R 1< , with each R 1< being the same or different and independently representing halogen, hydroxy, NH 2 , NO 2 , cyano, C 1-6 alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 alkyl, C 1-6 alkoxy, or halogenated C 1-6 alkoxy; (R 2< ) p2 indicates that the quinazoline ring in Formula (PBM-1) is substituted with p2 R 2< , with each R 2< being the same or different and independently representing halogen, NO 2 , cyano, halogenated C 1-6 alkyl, C 1-10 alkyl, deuterated C 1-10 alkyl, C 1-10 alkoxy, halogenated C 1-10 alkoxy, -O-optionally substituted heterocyclyl, or -NHC(O)R 3< , wherein R 3< is C 1-10 alkyl, deuterated C 1-10 alkyl, or C 2-10 alkenyl, e.g., R 2< represents methyl, methoxy, such as p1 represents an integer of 1, 2, 3, 4 or 5; p2 represents an integer of 1, 2, or 3; (R 4< ) p3 indicates that the benzene ring in Formula (PBM-2) is substituted with p3 R 4< , with each R 4< being the same or different and independently representing halogen, NO 2 , cyano, halogenated C 1-6 alkyl, C 1-10 alkyl, deuterated C 1-10 alkyl, C 1-10 alkoxy, or -NHC(O)R 15a< , where R 15a< is C 1-10 alkyl, deuterated C 1-10 alkyl, or C 2-10 alkenyl, e.g., R 4< represents methyl, methoxy, NO 2 , or p3 represents an integer of 1, 2, 3 or 4; (R 5< ) p4 indicates that the 1H-indole ring in Formula (PBM-2) is substituted with p4 R 5< , with each R 5< being the same or different and independently representing hydrogen, C 1-10 alkyl or deuterated C 1-10 alkyl, and p4 represents an integer of 0, 1, 2 or 3; R 6< represents hydrogen, C 1-10 alkyl, or deuterated C 1-10 alkyl; (R 7< ) p5 indicates that the benzene ring in Formula (PBM-3) is substituted with p5 R 7< , with each R 7< being the same or different and independently representing halogen, hydroxy, C 1-6 alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 alkyl, NO 2 , NH 2 , or cyano; p5 represents an integer of 0, 1, 2, 3, 4 or 5; R 8< represents substituted or unsubstituted C 3-15 cycloalkyl, such as Cyclopentyl; (R 9< ) p6 indicates that the benzene ring in Formula (PBM-4) is substituted with p6 R 9< , with each R 9< being the same or different and independently representing halogen, hydroxy, C 1-6 alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 alkyl, NO 2 , NH 2 , C 1-6 alkoxy, halogenated C 1-6 alkoxy, or cyano; p6 represents an integer of 2, 3, 4 or 5; R 10< represents C 6-10 aryl, or heteroaryl containing one or two 5- to 7-membered rings and 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulfur, wherein the C 6-10 aryl and heteroaryl are each optionally substituted with one or more R b1< , with each R b1< being the same or different and independently representing halogen, hydroxy, cyano, amino, nitro, C 1-6 alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 alkyl, C 1-6 alkoxy, or halogenated C 1-6 alkoxy; (R 11< ) p7 indicates that the benzene ring and the pyridine ring in Formula (PBM-5) are each optionally substituted with p7 R 11< , with each p7 being the same or different and independently representing an integer of 0, 1, 2 or 3, and each R 11< in Formula (PBM-5) is the same or different and each independently represents hydrogen, halogen, C 1-6 alkyl, halogenated C 1-6 alkyl, or deuterated C 1-6 alkyl; R 12< represents hydrogen, C 1-6 alkyl, halogenated C 1-6 alkyl, or deuterated C 1-6 alkyl; R 13< in Formula (PBM-6) represents hydrogen, C 1-10 alkyl (e.g., ), deuterated C 1-10 alkyl or halogenated C 1-10 alkyl; R 14< represents wherein (R b2< ) p8 indicates that the piperidine ring is optionally substituted with p8 R b2< , with each R b2< being the same or different and independently representing deuterium, halogen, hydroxy, C 1-6 alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 alkyl, C 1-6 alkoxy, halogenated C 1-6 alkoxy, deuterated C 1-6 alkoxy, NO 2 , NH 2 , or cyano, p8 represents an integer of 1, 2, 3, 4 or 5; ring A in Formula (PBM-7) represents C 6-10 aryl or 5- to 20-membered monocyclic or bicyclic heteroaryl containing from 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur, and the ring A is optionally substituted with one or more R b3< , with each R b3< being the same or different and independently representing deuterium, halogen, hydroxy, cyano, amino, nitro, C 1-6 alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 alkyl, C 1-6 alkoxy, halogenated C 1-6 alkoxy, C 2-6 alkenyl, or C 2-6 alkynyl; ring B in Formula (PBM-7) represents C 3-15 cycloalkyl or 3- to 20-membered heterocyclyl containing from 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur, and the ring B is optionally substituted with one or more R b4< , with each R b4< being the same or different and independently representing deuterium, halogen, C 1-6 alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 alkyl, C 1-6 alkoxy, or halogenated C 1-6 alkoxy; ring C in Formula (PBM-7) represents 5- to 20-membered monocyclic or bicyclic heteroaryl containing from 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur, and the ring C is optionally substituted with one or more R b5< , with each R b5< being the same or different and independently representing deuterium, halogen, hydroxy, cyano, amino, C 1-6 alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 alkyl, C 1-6 alkoxy, or halogenated C 1-6 alkoxy; R 15< in Formula (PBM-8) represents 4- to 20-membered heterocyclyl containing from 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur, and the heterocyclyl is optionally substituted with one or more R b6< , with each R b6< being the same or different and independently representing halogen, hydroxy, cyano, amino, nitro, C 1-6 alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 alkyl, C 1-6 alkoxy, or halogenated C 1-6 alkoxy; (R 16< ) p9 indicates that the benzene ring in Formula (PBM-8) is substituted with p9 R 16< , with each R 16< being the same or different and independently representing halogen, C 1-6 alkyl, halogenated C 1-6 alkyl, or deuterated C 1-6 alkyl, and p9 represents an integer of 1, 2, 3 or 4; X 1 in Formula (PBM-9) represents N or CR b7< , wherein R b7< is hydrogen or amino, and X 2 represents N or CR 17< , wherein R 17< is hydrogen or represents a bond, and X 3 represents CH or N; R 18< and R 19< each independently represent hydrogen or a bond; (R 20< ) p10 indicates that the benzene ring in Formula (PBM-9) is substituted with p10 R 20< , with each R 20< being the same or different and independently representing -O-aryl, -O-heteroaryl, -C 1-3 alkylene-NHC(O)-heteroaryl, -C 1-3 alkylene-C(O)NH-heteroaryl or halogen, wherein the aryl and heteroaryl are each independently optionally substituted with one or more R b8< , with each R b8< being the same or different and independently representing deuterium, halogen, hydroxy, cyano, amino, C 1-6 alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 alkyl, C 1-6 alkoxy, or halogenated C 1-6 alkoxy; ρ10 represents an integer of 1, 2, 3 or 4; R 21< represents a bond, deuterium, hydrogen, halogen, C 1-6 alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 alkyl, or C 1-6 alkoxy; R 22< represents hydrogen, halogen, cyano, or amino; wherein R 17< , R 18< , R 19< , and R 21< are not simultaneously hydrogen, and R 17< , R 18< , R 19< , and R 21< do not simultaneously represent a bond, and only one of R 17< , R 18< , R 19< , and R 21< represents a bond, wherein when R 18< represents a bond, the carbon atom on the ring connected to R 18< is directly connected to R f , X 2 represents CH or N, and R 19< is hydrogen, and R 21< is not a bond; when X 2 represents CR 17< ', where R 17< represents a bond, the carbon atom on the ring connected to R 17< is directly connected to R f , and R 18< and R 19< are hydrogen, and R 21< is not a bond; when R 19< represents a bond, the nitrogen atom on the ring connected to R 19< is directly connected to R f , X 2 represents N or CH, and R 18< is hydrogen, and R 21< is not a bond; and when R 21< represents a bond, the carbon atom on the ring connected to R 21< is directly connected to R f , and X 2 represents N or CH, and R 18< and R 19< are hydrogen; (R 23< ) p11 indicates that the cyclopentene ring in Formula (PBM-10) is substituted with p11 R 23< , with each R 23< being the same or different and independently representing halogen, C 1-6 alkyl, halogenated C 1-6 alkyl, or deuterated C 1-6 alkyl, and p11 represents an integer of 1, 2, 3, or 4; (R 24< ) p12 indicates that the pyridine ring in Formula (PBM-10) is substituted with p12 R 24< , with each R 24< being the same or different and independently representing halogen, -C 1-3 alkylene-OH, C 1-6 alkyl, halogenated C 1-6 alkyl, or deuterated C 1-6 alkyl, and p12 represents an integer of 1, 2, or 3; R 25< represents hydrogen, C 1-6 alkyl, halogenated C 1-6 alkyl, or deuterated C 1-6 alkyl; X 4 in Formula (PBM-11) represents CR 26< or a fragment wherein symbol # indicates the point of attachment to N atom adjacent to X 4 , symbol ## indicates the point of attachment to X 5 , and R 26< represents deuterium, hydrogen, halogen, C 1-6 alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 alkyl, - C(O)-C 1-6 alkyl, -C(O)-deuterated C 1-6 alkyl, or -C(O)NR b9< R b10< , where R b9< and R b10< are the same or different and each independently represent hydrogen, C 1-6 alkyl or deuterated C 1-6 alkyl; X 5 in Formula (PBM-11) represents N or CR 27< , where R 27< represents hydrogen, deuterium, halogen, C 1-6 alkyl, deuterated C 1-6 alkyl, or halogenated C 1-6 alkyl; X 6 and X 7 each independently represent CH or N; R 28< represents a bond or optionally substituted heteroarylene (e.g., halogenated heteroarylene); R 29< represents hydrogen, C 1-6 alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 alkyl, or optionally substituted C 3-7 cycloalkyl; R 30< and R 31< are the same or different and each independently represent hydrogen, halogen, C 1-6 alkyl, halogenated C 1-6 alkyl, or deuterated C 1-6 alkyl; R 32< in Formula (PBM-12) represents hydrogen, halogen, C 1-6 alkyl, halogenated C 1-6 alkyl, or deuterated C 1-6 alkyl; R 33< represents hydrogen, cyano, halogen, C 1-6 alkyl, halogenated C 1-6 alkyl, or deuterated C 1-6 alkyl; (R 34< ) p13 indicates that the benzene ring in Formula (PBM-13) is substituted with p13 R 34< , with each R 34< being the same or different and independently representing halogen, hydroxy, amino, cyano, C 1-6 alkyl, halogenated C 1-6 alkyl, or deuterated C 1-6 alkyl; p13 represents an integer of 1, 2, 3, 4 or 5; R 35< represents NR b11< R b12< , where R b11< and R b12< are the same or different and each independently represent hydrogen, C 1-6 alkyl, halogenated C 1-6 alkyl, or deuterated C 1-6 alkyl; (R 36< ) p14 indicates that the benzene ring in Formula (PBM-14) is optionally substituted with p14 R 36< , with each R 36< in Formula (PBM-14) being the same or different and independently representing halogen, amino, cyano, C 1-6 alkyl, halogenated C 1-6 alkyl, or deuterated C 1-6 alkyl, and p14 represents an integer of 1, 2 or 3; R 37< represents hydrogen, C 1-6 alkyl, halogenated C 1-6 alkyl, or deuterated C 1-6 alkyl; X 8 , X 9 , X 10 , X 11 , and X 12 in Formula (PBM-15) are the same or different and each independently represent N or CH; R 38< represents a bond or optionally substituted methylene (e.g., halogenated methylene); R 39< represents -C(O)NHR b13< , -NHC(O)-R b13< , -S(O) 2 NHR b13< , -N(R b14< )S(O) 2 R b13< , -S(O) 2 R b13< or - P(O)(R b13< ) 2 , wherein each R b13< is the same or different and each independently represents C 1-6 alkyl or deuterated C 1-6 alkyl, and R b14< represents hydrogen or C 1-6 alkyl; (R 40< ) p15 indicates that the 6-membered ring containing X 9 and X 10 in Formula (PBM-15) is optionally substituted with p15 R 40< , with each R 40< being the same or different and independently representing halogen, C 1-6 alkoxy, C 1-6 alkyl, deuterated C 1-6 alkyl or halogenated C 1-6 alkyl; p15 represents an integer of 0, 1, 2, 3 or 4; R 41< represents halogen, C 1-6 alkoxy, C 1-6 alkyl, deuterated C 1-6 alkyl or halogenated C 1-6 alkyl; (R 42< ) p16 indicates that the benzene ring in Formula (PBM-16) is optionally substituted with p16 R 42< , with each R 42< being the same or different and independently representing halogen, C 1-6 alkoxy, C 1-6 alkyl, deuterated C 1-6 alkyl or halogenated C 1-6 alkyl; each p16 is the same or different and each independently represents an integer of 0, 1, 2, 3 or 4; (R 43< ) p17 indicates that the benzene ring in Formula (PBM-17) is substituted with p17 R 43< , with each R 43< being the same or different and independently representing halogen, C 1-6 alkoxy, C 1-6 alkyl, deuterated C 1-6 alkyl or halogenated C 1-6 alkyl, and p17 represents an integer of 0, 1, 2, 3 or 4; (R 44< ) p18 indicates that the benzene ring in Formula (PBM-18) is optionally substituted with p18 R 44< , with each R 44< being the same or different and independently representing halogen, C 1-6 alkoxy, C 1-6 alkyl, deuterated C 1-6 alkyl or halogenated C 1-6 alkyl; p18 represents an integer of 0, 1, 2, 3 or 4; (R 45< ) p19 indicates that the 4-oxo-3,4-dihydroquinazoline ring in Formula (PBM-18) is substituted with p19 R 45< , with each R 45< being the same or different and independently representing halogen, C 1-6 alkoxy, C 1-6 alkyl, deuterated C 1-6 alkyl or halogenated C 1-6 alkyl; p19 represents an integer of 1, 2, 3 or 4; (R 46< ) p20 indicates that the benzene ring in Formula (PBM-19) is substituted with p20 R 46< , with each R 46< being the same or different and independently representing halogen, C 1-6 alkoxy, C 1-6 alkyl, deuterated C 1-6 alkyl, or halogenated C 1-6 alkyl; p20 represents an integer of 1, 2, 3, 4 or 5; R 47< represents halogen, C 1-6 alkyl, deuterated C 1-6 alkyl, or halogenated C 1-6 alkyl; (R 48< ) p21 indicates that the quinoline ring in Formula (PBM-20) is substituted with p21 R 48< , with each R 48< being the same or different and independently representing halogen, cyano, C 1-6 alkoxy, C 1-6 alkyl, deuterated C 1-6 alkyl, or halogenated C 1-6 alkyl; p21 represents an integer of 1, 2, 3 or 4; (R 49< ) p22 indicates that the benzene ring in Formula (PBM-20) is substituted with p22 R 49< , with each R 49< being the same or different and independently representing halogen, C 1-6 alkoxy, C 1-6 alkyl, deuterated C 1-6 alkyl, or halogenated C 1-6 alkyl; p22 represents an integer of 2, 3 or 4; R 50< in Formula (PBM-21) represents -NHC(O)- or -C(O)NH-; R 51< represents -NH- or ethynylene; (R 52< ) p23 indicates that the benzene rings in Formula (PBM-21) are each optionally substituted with p23 R 52< , with each R 52< being the same or different and independently representing halogen, C 1-6 alkoxy, C 1-6 alkyl, deuterated C 1-6 alkyl, or halogenated C 1-6 alkyl; each p23 is the same or different and each independently represents an integer of 0, 1, 2, 3 or 4; ring D in Formula (PBM-21) represents 5- to 20-membered monocyclic or bicyclic heteroaryl containing from 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur, and (R 53< ) p24 indicates that the ring D is optionally substituted with p24 R 53< , with each R 53< being the same or different and independently representing optionally substituted 5- to 15-membered heteroaryl, deuterium, halogen, hydroxy, cyano, amino, C 1-6 alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 alkyl, C 1-6 alkoxy, or halogenated C 1-6 alkoxy; p24 represents an integer of 0, 1, 2, or 3; only one of R 54< , R 55< , R 56< , and R 57< in Formula (PBM-22) represents a bond, and the remaining are the same or different and each independently represent hydrogen, halogen, or hydroxy, wherein when one of R 54< , R 55< , R 56< and R 57< represents a bond, the benzene ring or methylene in Formula (PBM-22) connected to the bond is directly connected to R f ; symbol "" connected to a double bond in Formula (PBM-22) represents a bond in stereo-configuration (cis or trans configuration, or E- or Z-configuration); X 13 in Formula (PBM-23) represents -O- or -CH 2 -; (R 58< ) p25 indicates that 1,2,3,4-tetrahydronaphthalene ring in Formula (PBM-23) is substituted with p25 R 58< , with each R 58< being the same or different and independently representing hydrogen, hydroxy, halogen, C 1-6 alkyl, halogenated C 1-6 alkyl, or deuterated C 1-6 alkyl; p25 represents an integer of 1, 2, 3 or 4; one of R 59< and R 60< represents a bond, and another represents hydrogen, halogen, C 1-6 alkyl, deuterated C 1-6 alkyl or halogenated C 1-6 alkyl, wherein when one of R 59< and R 60< represents a bond, the carbon atom on the ring in Formula (PBM-23) connected to the bond is directly connected to R f ; ring E in Formula (PBM-24) represents 5- to 20-membered monocyclic or bicyclic heteroarylene containing from 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur; R 62< represents optionally substituted 5- to 15-membered heteroaryl, optionally substituted 5- to 15-membered heterocyclyl, deuterium, halogen, hydroxy, cyano, amino, C 1-6 alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 alkyl, C 1-6 alkoxy, or halogenated C 1-6 alkoxy; R 61< represents halogen, C 1-6 alkyl, halogenated C 1-6 alkyl, or deuterated C 1-6 alkyl; R 63< in Formula (PBM-25) represents optionally substituted 5- to 15-membered heterocyclyl, deuterium, halogen, hydroxy, cyano, amino, C 1-6 alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 alkyl, C 1-6 alkoxy, or halogenated C 1-6 alkoxy; R 64< represents 5- to 20-membered monocyclic or bicyclic heteroaryl containing from 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur, and the heteroaryl is optionally substituted with one or more substituents selected from the group consisting of deuterium, halogen, hydroxy, cyano, amino, C 1-6 alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 alkyl, C 1-6 alkoxy, halogenated C 1-6 alkoxy, or any combination thereof; (R 65< ) p26 indicates that the isoquinoline ring in Formula (PBM-26) is substituted with p26 R 65< , with each R 65< being the same or different and independently representing hydrogen, hydroxy, halogen, C 1-6 alkyl, C 1-6 alkoxy, -C(O)NH 2 , deuterated C 1-6 alkyl, or halogenated C 1-6 alkyl; p26 represents an integer of 1, 2, 3 or 4; groups R 66< are the same or different and each independently represent hydrogen, hydroxy, halogen, C 1-6 alkyl, C 1-6 alkoxy, deuterated C 1-6 alkyl, or halogenated C 1-6 alkyl; X 14 in Formula (PBM-27) represents N or CR b23< , where R b23< represents hydrogen or halogen, and X 15 represents N or CH; R 67< represents a bond, -C(O)NH- or -NHC(O)-; R 68< represents halogen, C 1-6 alkyl, deuterated C 1-6 alkyl, or halogenated C 1-6 alkyl; R 69< represents hydrogen, C 1-6 alkyl, deuterated C 1-6 alkyl, halogenated C 1-6 alkyl, or -C 1-3 alkylene-C 3-6 cycloalkyl; R 70< represents hydrogen, C 1-6 alkyl, deuterated C 1-6 alkyl, or halogenated C 1-6 alkyl; or R 69< and R 70< together with the corresponding nitrogen and carbon atoms to which they are connected form an optionally substituted 5- to 7-membered nitrogen-containing heterocycle; R 71< represents hydrogen or a bond, R 72< represents hydrogen or a bond, wherein R 71< and R 72< are not simultaneously hydrogen, and only one of R 71< and R 72< represents a bond, and another represents hydrogen, wherein when R 71< represents a bond, the carbon atom on the ring connected to R 71< is directly connected to R f , and when R 72< represents a bond, the carbon atom on the ring connected to R 72< is directly connected to R f ; R 74< in Formula (PBM-28) represents C 1-3 alkylene or halogenated C 1-3 alkylene; R 73< represents optionally substituted C 3-6 cycloalkyl, halogenated C 3-6 cycloalkyl, or optionally substituted C 1-6 alkyl; R 75< in Formula (PBM-29) represents C 1-3 alkylene or halogenated C 1-3 alkylene; R 76< represents C 1-6 alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 alkyl, or optionally substituted C 3-6 cycloalkyl; R 77< in Formula (PBM-30) represents C 1-3 alkylene or halogenated C 1-3 alkylene; R 78< represents hydroxy, halogen, C 1-6 alkyl, C 1-6 alkoxy, deuterated C 1-6 alkyl, or halogenated C 1-6 alkyl; R 79< and R 80< are the same or different and each independently represent hydrogen, optionally substituted C 1-10 alkyl or optionally substituted C 3-6 cycloalkyl; R 81< represents hydrogen, halogen, C 1-6 alkyl, deuterated C 1-6 alkyl, or halogenated C 1-6 alkyl; X 16 in Formula (PBM-31) represents -S- or a fragment wherein when X 16 represents -S-, heteroaryl containing X 16 and nitrogen atom in Formula (PBM-31) is thiazolyl, and when X 16 represents the fragment the heteroaryl containing X 16 and nitrogen atom in Formula (PBM-31) is pyridyl; X 17 represents N or CH; R 82< represents hydrogen or optionally substituted C 1-10 alkyl; R 83< represents hydrogen, -C 1-3 alkylene-optionally substituted 4- to 10-membered heterocyclyl, or optionally substituted 4- to 10-membered heterocyclyl; R 84< represents hydroxy, halogen, C 1-6 alkyl, C 1-6 alkoxy, deuterated C 1-6 alkyl, or halogenated C 1-6 alkyl; R 85< and R 86< in Formula (PBM-32) are the same or different and each independently represent hydroxy, halogen, C 1-6 alkyl, C 1-6 alkoxy, deuterated C 1-6 alkyl, or halogenated C 1-6 alkyl; R 87< represents -S(O) 2 NH 2 or -C(O)NH 2 ; R 88< in Formula (PBM-33) represents hydrogen, hydroxy, halogen, C 1-6 alkyl, deuterated C 1-6 alkyl, or halogenated C 1-6 alkyl; R 89< represents C 1-6 alkyl, deuterated C 1-6 alkyl, or halogenated C 1-6 alkyl; or R 88< and R 89< together with the corresponding carbon and nitrogen atoms to which they are connected form an optionally substituted 4- to 6-membered heteroaromatic ring or optionally substituted 4- to 6-membered heterocycle; R 90< represents optionally substituted C 3-6 cycloalkyl, C 1-6 alkyl, deuterated C 1-6 alkyl, halogenated C 1-6 alkyl or optionally substituted 4- to 10-membered heterocyclyl; (R 91< ) p27 indicates that pyridin-2(1H)-one ring in Formula (PBM-33) is substituted with p27 R 91< , with each R 91< being the same or different and independently representing hydroxy, halogen, C 1-6 alkyl, C 1-6 alkoxy, deuterated C 1-6 alkyl, or halogenated C 1-6 alkyl; p27 represents an integer of 1, 2 or 3; ring F in Formula (PBM-33) represents arylene or 5- to 20-membered monocyclic or bicyclic heteroarylene containing from 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur; and (R 92< ) p28 indicates that the ring F is optionally substituted with p28 R 92< , with each R 92< being the same or different and independently representing deuterium, halogen, hydroxy, cyano, amino, C 1-6 alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 alkyl, C 1-6 alkoxy, or halogenated C 1-6 alkoxy; p28 represents an integer of 0, 1, 2, 3 or 4; (R 93< ) p29 indicates that the benzene ring in Formula (PBM-34) is substituted with p29 R 93< , with each R 93< being the same or different and independently representing hydroxy, amino, cyano, halogen, C 1-6 alkyl, C 1-6 alkoxy, deuterated C 1-6 alkyl, or halogenated C 1-6 alkyl; p29 represents an integer of 1, 2, 3, 4 or 5; R 94< represents hydrogen, hydroxy, amino, cyano, halogen, C 1-6 alkyl, C 1-6 alkoxy, deuterated C 1-6 alkyl, or halogenated C 1-6 alkyl; R 95< represents NR b15< R b16< , where R b15< and R b16< are the same or different and each independently represent hydrogen, C 1-6 alkyl, deuterated C 1-6 alkyl, halogenated C 1-6 alkyl, optionally substituted C 3-6 cycloalkyl, or optionally substituted 4- to 8-membered heterocyclyl; X 18 , X 19 and X 20 in Formula (PBM-35) are the same or different and each independently represent CH or N, wherein X 18 , X 19 and X 20 are not simultaneously N, and the 6-membered ring containing X 18 , X 19 , X 20 and nitrogen atom is optionally substituted with 1 or 2 substituents selected from the group consisting of halogen, cyano, C 1-6 alkyl, deuterated C 1-6 alkyl, halogenated C 1-6 alkyl, or any combination thereof; X 21 and X 22 in Formula (PBM-35) are the same or different and each independently represent C or N, wherein X 21 and X 22 are not simultaneously N; (R 96< ) p30 indicates that the benzene ring in Formula (PBM-35) is substituted with p30 R 96< , with each R 96< being the same or different and independently representing hydroxy, amino, cyano, halogen, C 1-6 alkyl, C 1-6 alkoxy, deuterated C 1-6 alkyl, or halogenated C 1-6 alkyl; p30 represents an integer of 1, 2, 3, 4 or 5; (R 97< ) p31 indicates that the pyrrolidine ring in Formula (PBM-35) is optionally substituted with p31 R 97< , with each R 97< being the same or different and independently representing hydrogen, hydroxy, amino, cyano, halogen, C 1-6 alkyl, C 1-6 alkoxy, deuterated C 1-6 alkyl, or halogenated C 1-6 alkyl; p31 represents an integer of 0, 1, 2, 3, 4, 5 or 6; R 98< , R 99< , and R 100< are the same or different and each independently represent hydrogen, halogen, C 1-6 alkyl, deuterated C 1-6 alkyl, or halogenated C 1-6 alkyl; X 23 in Formula (PBM-36) represents CH or N; R 101< represents a bond or -S-; R 102< represents a bond or optionally substituted 4- to 15-membered nitrogen-containing heterocyclyl; R 103< represents a bond, halogen, amino, C 1-6 alkyl, deuterated C 1-6 alkyl, halogenated C 1-6 alkyl, or optionally substituted 4- to 15-membered nitrogen-containing heterocyclyl; wherein R 102< and R 103< are not simultaneously a bond, and only one of R 102< and R 103< is a bond, wherein when R 102< represents a bond, the carbon atom on the ring connected to R 102< is directly connected to R f , and when R 103< represents a bond, the carbon atom on the ring connected to R 103< is directly connected to R f ; (R 104< ) p32 indicates that the 6-membered ring in Formula (PBM-36) is optionally substituted with p32 R 104< , with each R 104< being the same or different and independently representing hydroxy, amino, cyano, halogen, C 1-6 alkyl, C 1-6 alkoxy, deuterated C 1-6 alkyl, or halogenated C 1-6 alkyl; p32 represents an integer of 0, 1, 2, 3 or 4; (R 105< ) p33 indicates that the benzene ring in Formula (PBM-37) is optionally substituted with p33 R 105< , with each R 105< being the same or different and independently representing hydroxy, amino, cyano, halogen, C 1-6 alkyl, C 1-6 alkoxy, deuterated C 1-6 alkyl, or halogenated C 1-6 alkyl; p33 represents an integer of 1, 2, 3 or 4; (R 106< ) p34 indicates that the phthalazinone ring in Formula (PBM-37) is optionally substituted with p34 R 106< , with each R 106< being the same or different and independently representing hydroxy, amino, cyano, halogen, C 1-6 alkyl, C 1-6 alkoxy, deuterated C 1-6 alkyl or halogenated C 1-6 alkyl; p34 represents an integer of 0, 1, 2, 3 or 4; (R 107< ) p35 indicates that the 2H-indazole ring in Formula (PBM-38) is optionally substituted with p35 R 107< , with each R 107< being the same or different and independently representing hydroxy, amino, cyano, halogen, C 1-6 alkyl, C 1-6 alkoxy, deuterated C 1-6 alkyl or halogenated C 1-6 alkyl; p35 represents an integer of 0, 1, 2 or 3; (R 108< ) p36 indicates that the benzene ring in Formula (PBM-38) is optionally substituted with p36 R 108< , with each R 108< being the same or different and independently representing hydroxy, amino, cyano, halogen, C 1-6 alkyl, C 1-6 alkoxy, deuterated C 1-6 alkyl or halogenated C 1-6 alkyl; p36 represents an integer of 0, 1, 2 or 3; (R 109< ) p37 indicates that the 2H-indazole ring in Formula (PBM-39) is optionally substituted with p37 R 109< , with each R 109< being the same or different and independently representing hydroxy, amino, cyano, halogen, C 1-6 alkyl, C 1-6 alkoxy, deuterated C 1-6 alkyl or halogenated C 1-6 alkyl; p37 represents an integer of 0, 1, 2 or 3; (R 110< ) p38 indicates that the benzene ring in Formula (PBM-39) is optionally substituted with p38 R 110< , with each R 110< being the same or different and independently representing hydroxy, amino, cyano, halogen, C 1-6 alkyl, C 1-6 alkoxy, deuterated C 1-6 alkyl or halogenated C 1-6 alkyl; p38 represents an integer of 0, 1, 2 or 3; (R 111< ) p39 indicates that the benzene ring in Formula (PBM-40) is optionally substituted with p39 R 111< , with each R 111< being the same or different and independently representing hydroxy, amino, cyano, halogen, C 1-6 alkyl, C 1-6 alkoxy, deuterated C 1-6 alkyl or halogenated C 1-6 alkyl; p39 represents an integer of 0, 1, 2, 3 or 4; R 112< , R 113< , and R 114< are the same or different and each independently represent hydrogen, halogen, C 1-6 alkyl, deuterated C 1-6 alkyl or halogenated C 1-6 alkyl; R 115< in Formula (PBM-41) represents hydrogen, C 1-6 alkyl, deuterated C 1-6 alkyl or halogenated C 1-6 alkyl; R 116< , R 117< , and R 118< are the same or different and each independently represent hydrogen, halogen, C 1-6 alkyl, deuterated C 1-6 alkyl or halogenated C 1-6 alkyl; (R 119< ) p40 indicates that the benzene ring in Formula (PBM-41) is optionally substituted with p40 R 119< , with each R 119< being the same or different and independently representing hydroxy, amino, cyano, halogen, C 1-6 alkyl, C 1-6 alkoxy, deuterated C 1-6 alkyl or halogenated C 1-6 alkyl; p40 represents an integer of 0, 1, 2, 3 or 4; R 120< and R 121< in Formula (PBM-42) are the same or different and each independently represent hydrogen, halogen, C 1-3 alkyl or halogenated C 1-3 alkyl; R 122< represents a bond, hydrogen, C 1-6 alkyl, deuterated C 1-6 alkyl or halogenated C 1-6 alkyl; R 123< represents the structure of the following formula: wherein R 124< represents a bond or hydrogen; and (R 125< ) p41 indicates that the benzene ring is optionally substituted with p41 R 125< , with each R 125< being the same or different and independently representing hydroxy, amino, cyano, halogen, C 1-6 alkyl, C 1-6 alkoxy, deuterated C 1-6 alkyl or halogenated C 1-6 alkyl, and p41 represents an integer of 0, 1, 2, 3 or 4; or R 123< represents the structure of the following formula: wherein (R 126< ) p42 indicates that the benzene ring is optionally substituted with p42 R 126< , with each R 126< being the same or different and independently representing hydroxy, amino, cyano, halogen, C 1-6 alkyl, C 1-6 alkoxy, deuterated C 1-6 alkyl or halogenated C 1-6 alkyl, and p42 represents an integer of 0, 1, 2, 3, 4 or 5; wherein R 122< and R 124< are not simultaneously a bond, and only one of R 122< and R 124< represents a bond, wherein when R 122< represents a bond, the nitrogen atom on the ring connected to R 122< is directly connected to R f , and when R 124< represents a bond, the carbon atom on the ring connected to R 124< is directly connected to R f ; (R 127< ) p43 indicates that the benzene ring in Formula (PBM-43) is optionally substituted with p43 R 127< , with each R 127< being the same or different and independently representing hydroxy, amino, cyano, halogen, C 1-6 alkyl, C 1-6 alkoxy, deuterated C 1-6 alkyl or halogenated C 1-6 alkyl; p43 represents an integer of 0, 1, 2, 3 or 4; R 131< in Formula (PBM-45) represents C 1-6 alkyl, deuterated C 1-6 alkyl, halogenated C 1-6 alkyl or hydrogen; R 132< represents C 1-6 alkyl, deuterated C 1-6 alkyl, halogenated C 1-6 alkyl, optionally substituted C 3-6 cycloalkyl, optionally substituted 4- to 8-membered nitrogen-containing heterocyclyl or NR b17< R b18< , where R b17< and R b18< are the same or different and each independently represent hydrogen, C 1-6 alkyl, deuterated C 1-6 alkyl or optionally substituted 4- to 8-membered heterocyclyl; (R 133< ) p46 indicates that the benzene ring in Formula (PBM-45) is optionally substituted with p46 R 133< , with each R 133< being the same or different and independently representing hydroxy, amino, cyano, halogen, C 1-6 alkyl, C 1-6 alkoxy, deuterated C 1-6 alkyl or halogenated C 1-6 alkyl; p46 represents an integer of 0, 1, 2, 3 or 4; (R 134< ) p47 indicates that the benzene ring in Formula (PBM-46) is optionally substituted with p47 R 134< , with each R 134< being the same or different and independently representing hydroxy, amino, cyano, halogen, C 1-6 alkyl, C 1-6 alkoxy, deuterated C 1-6 alkyl or halogenated C 1-6 alkyl; p47 represents an integer of 0, 1, 2, 3 or 4; (R 135< ) p48 indicates that the benzene ring in Formula (PBM-46) is optionally substituted with p48 R 135< , with each R 135< being the same or different and independently representing hydroxy, amino, cyano, halogen, C 1-6 alkyl, C 1-6 alkoxy, deuterated C 1-6 alkyl or halogenated C 1-6 alkyl; p48 represents an integer of 0, 1, 2, 3 or 4; ring H in Formula (PBM-48) represents C 6-10 arylene or C 5-10 heteroarylene, and (R 137< ) p49 indicates that the ring H is optionally substituted with p49 R 137< , with each R 137< being the same or different and independently representing deuterium, halogen, hydroxy, cyano, amino, nitro, C 1-6 alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 alkyl, C 1-6 alkoxy, or halogenated C 1-6 alkoxy; p49 represents an integer of 0, 1, 2, 3 or 4; R 136< represents optionally substituted 5- to 20-membered monocyclic or bicyclic heteroaryl containing from 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur, which is optionally substituted with a substituent selected from the group consisting of hydroxy, amino, cyano, halogen, C 1-6 alkyl, C 1-6 alkoxy, deuterated C 1-6 alkyl or halogenated C 1-6 alkyl; X 24 , X 25 , and X 26 in Formula (PBM-49) each independently represents CH or N; R 138< represents -C(O)NHR b19< , -NHC(O)-R b19< , -S(O) 2 NHR b19< , -NHS(O) 2 R b19< , -S(O) 2 R b19< or - P(O)(R b19< ) 2 , wherein each R b19< is the same or different and each independently represents C 1-6 alkyl or deuterated C 1-6 alkyl; R 139< and R 140< each independently represent halogen, hydroxy, cyano, amino, nitro, C 1-6 alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 alkyl, C 1-6 alkoxy, or halogenated C 1-6 alkoxy; (R 141< ) p50 indicates that the benzene ring is optionally substituted with p50 R 141< , with each R 141< being independently halogen, hydroxy, cyano, amino, nitro, C 1-6 alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 alkyl, C 1-6 alkoxy, or halogenated C 1-6 alkoxy; p50 represents an integer of 0, 1, 2, 3 or 4; and (R 143< ) p51 in Formula (PBM-50) indicates that the benzene ring is optionally substituted with p51 R 143< , with each R 143< being independently halogen, hydroxy, cyano, amino, nitro, C 1-6 alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 alkyl, C 1-6 alkoxy, or halogenated C 1-6 alkoxy; p51 represents an integer of 0, 1, 2, 3, 4 or 5; R 142< represents H, C 1-6 alkyl or halogenated C 1-6 alkyl; (R 144< ) p52 indicates that the quinazoline ring in Formula (PBM-50) is optionally substituted with p52 R 144< , with each R 144< being independently halogen, hydroxy, cyano, amino, nitro, C 1-6 alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 alkyl, C 1-6 alkoxy, or halogenated C 1-6 alkoxy, and p52 represents an integer of 1, 2, or 3; R f2 in Formula (PBM-51) represents a bond, or R f2 represents -NH-R f3 -C(O)-***, wherein symbol *** indicates the point of attachment to R f1 , and R f3 represents optionally substituted C 3-8 cycloalkyl; (R 145< ) p53 indicates that the 1H-pyrrolo[2,3-b]pyridine ring in Formula (PBM-51) is optionally substituted with p53 R 145< , with each R 145< being independently cyano, halogen, hydroxy, amino, nitro, C 1-6 alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 alkyl, C 1-6 alkoxy, or halogenated C 1-6 alkoxy, and p53 represents an integer of 0, 1, 2, 3, 4 or 5; (R 146< ) p54 indicates that the pyridine ring in Formula (PBM-51) is optionally substituted with p54 R 146< , with each R 146< being independently cyano, halogen, hydroxy, nitro, C 1-6 alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 alkyl, C 1-6 alkoxy, or halogenated C 1-6 alkoxy or NR b25< R b26< , wherein R b25< and R b26< are the same or different and each independently represent hydrogen, C 1-6 alkyl, deuterated C 1-6 alkyl, halogenated C 1-6 alkyl, optionally substituted C 3-6 cycloalkyl or optionally substituted 4- to 8-membered heterocyclyl, and p54 represents an integer of 0, 1, 2 or 3; (R 147< ) p55 in Formula (PBM-52) indicates that the benzene ring is optionally substituted with p55 R 147< , with each R 147< being independently halogen, hydroxy, cyano, amino, nitro, C 1-6 alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 alkyl, C 1-6 alkoxy or halogenated C 1-6 alkoxy, and p55 represents an integer of 0, 1, 2, 3, 4 or 5; R 148< represents NHC(O) or C(O)NH; (R 149< ) p56 indicates that the 1H-pyrazole ring in Formula (PBM-52) is optionally substituted with p56 R 149< , with each R 149< being independently halogen, hydroxy, cyano, amino, nitro, C 1-6 alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 alkyl, C 1-6 alkoxy or halogenated C 1-6 alkoxy, and p56 represents an integer of 0, 1 or 2; and X 27 in Formula (PBM-53) represents N or CH; R 150< represents a bond or optionally substituted methylene (e.g., halogenated methylene); ring I represents C 6-10 arylene or 5- to 15-membered heteroarylene, and (R 151< ) p57 indicates that the ring I is optionally substituted with p57 R 151< , with each R 151< being the same or different and independently representing deuterium, halogen, hydroxy, cyano, amino, nitro, oxo, C 1-6 alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 alkyl, C 1-6 alkoxy, or halogenated C 1-6 alkoxy, and p57 represents an integer of 0, 1, 2, 3 or 4; (R 152< ) p58 indicates that the 6-membered ring containing X 27 in Formula (PBM-53) is optionally substituted with p58 R 152< , with each R 152< independently representing halogen, C 1-6 alkoxy, C 1-6 alkyl, deuterated C 1-6 alkyl or halogenated C 1-6 alkyl, and p58 represents an integer of 0, 1 or 2; (R 153< ) p59 indicates that the benzene ring in Formula (PBM-53) is optionally substituted with p59 R 153< , with each R 153< being the same or different and independently representing halogen, C 1-6 alkoxy, C 1-6 alkyl, deuterated C 1-6 alkyl or halogenated C 1-6 alkyl, and p15 represents an integer of 0, 1, 2, 3 or 4.

[0068] In some embodiments, PBM-R f - represents a small molecule ligand targeting EGFR.

[0069] In some embodiments, PBM represents the structures of Formula (PBM-1-1A), Formula (PBM-1-1B), Formula (PBM-1-1C) or Formula (PBM-1-1D): wherein in Formula (PBM-1-1A), Formula (PBM-1-1B), Formula (PBM-1-1C) and Formula (PBM-1-1D), (R 1< ) p1 each independently indicates that the benzene ring is substituted with p1 R 1< , with each R 1< being the same or different and independently representing halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxy, NH 2 , NO 2 , cyano, C 1-6 alkyl (e.g., C 1-4 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterated C 1-6 alkyl (e.g., perdeuterated C 1-6 alkyl or perdeuterated C 1-4 alkyl, such as CD 3 , CD 3 CD 2 -, CD 3 CD 2 CD 2 - etc.), halogenated C 1-6 alkyl (e.g., halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), C 1-6 alkoxy (e.g., C 1-4 alkoxy, such as methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy, or tert-butoxy), or halogenated C 1-6 alkoxy (e.g., halogenated C 1-4 alkoxy, such as F 3 C-O-, FCH 2 -O-, F 2 CH-O-, ClCH 2 -O-, Cl 2 CH-O-, CF 3 CF 2 -O-, CF 3 CHF-O-, CHF 2 CF 2 -O-, CHF 2 CHF-O-, CF 3 CH 2 -O- or CH 2 ClCH 2 -O-); (R 2< ) p2 each independently indicates that the quinazoline ring is substituted with p2 R 2< , with each R 2< being the same or different and independently representing halogen (e.g., fluorine, chlorine, bromine, or iodine), NO 2 , cyano, halogenated C 1-6 alkyl (e.g., halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), C 1-10 alkyl (e.g., C 1-8 alkyl, C 1-6 alkyl or C 1-4 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, hexyl, heptyl, or octyl), deuterated C 1-10 alkyl (e.g., perdeuterated C 1-8 alkyl, perdeuterated C 1-6 alkyl or perdeuterated C 1-4 alkyl, such as CD 3 , CD 3 CD 2 -, CD 3 CD 2 CD 2 - etc.), C 1-10 alkoxy (e.g., C 1-8 alkoxy, C 1-6 alkoxy or C 1-4 alkoxy, such as methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy, or tert-butoxy), halogenated C 1-10 alkoxy (e.g., halogenated C 1-4 alkoxy, such as trifluoromethoxy), -O-optionally substituted heterocyclyl (where heterocyclyl is e.g., 4- to 20-membered monocyclic or bicyclic heterocyclyl containing one or more (e.g., from 1 to 4, or 1, 2, 3, or 4) heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur), or -NHC(O)R 3< , wherein R 3< is C 1-10 alkyl (e.g., C 1-8 alkyl, C 1-6 alkyl or C 1-4 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, hexyl, heptyl, or octyl), deuterated C 1-10 alkyl (e.g., perdeuterated C 1-8 alkyl, perdeuterated C 1-6 alkyl or perdeuterated C 1-4 alkyl, such as CD 3 , CD 3 CD 2 -, CD 3 CD 2 CD 2 - etc.), or C 2-10 alkenyl (e.g., C 2-6 alkenyl or C 2-4 alkenyl, such as vinyl, propenyl, butenyl or pentenyl), e.g., R 2< represents methyl, methoxy, such as p1 represents an integer of 1, 2, 3, 4 or 5; and p2 represents an integer of 1, 2, or 3.

[0070] In some embodiments, R 2< represents -O-optionally substituted heterocyclyl, and the heterocyclyl is 4- to 20-membered (e.g., 4- to 15-membered, 4- to 12-membered, 4- to 10-membered, 4- to 7-membered, or 4- to 6-membered) monocyclic or bicyclic heterocyclyl group containing one or more (e.g., 1-4, or 1, 2, 3, or 4) heteroatoms selected from nitrogen, oxygen, and sulfur, and includes but is not limited to azetidinyl, oxetanyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, tetrahydrofuranyl, tetrahydropyranyl, tetrahydrothienyl, tetrahydrothiopyranyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, dioxacyclohexyl, azacycloheptyl, diazacycloheptanyl (e.g., 1,4-diazacycloheptan-1-yl), azacyclooctyl, diazacyclooctyl, azabicyclo[3.1.1]heptanyl, azabicyclo[2.2.1]heptanyl, azabicyclo[3.2.1]octanyl, azabicyclo[2.2.2]octanyl, diazabicyclo[3.1.1]heptanyl, diazabicyclo[2.2.1]heptanyl, diazabicyclo[3.2.1]octanyl (e.g., 3,8-diazabicyclo[3.2.1]octan-3-yl), diazabicyclo[2.2.2]octanyl (e.g., 2,5-diazabicyclo[2.2.2]octan-2-yl). In some embodiments, the heterocyclyl is optionally substituted with a substituent selected from the group consisting of deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C 1-6 alkyl, halogenated C 1-6 alkyl, optionally deuterated C 3-6 cycloalkyl, optionally deuterated C 1-6 alkoxy, optionally deuterated C 1-6 alkyl-NH-, NH 2 -C 1-6 alkylene, optionally deuterated C 1-6 alkyl-NHC(O)-, optionally deuterated C 1-6 alkyl-C(O)NH- or any combination thereof.

[0071] In some embodiments, R 2< represents: fluorine, chlorine, bromine, or iodine; methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, hexyl, heptyl or octyl; methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy, or tert-butoxy; -NHC(O)-C 2-10 alkenyl, e.g., -NHC(O)-vinyl (i.e., ), -NHC(O)-propenyl, or -NHC(O)-butenyl; or

[0072] In some embodiments, PBM represents the structures of Formula (PBM-1-1), Formula (PBM-1-2), Formula (PBM-1-3), Formula (PBM-1-4) or Formula (PBM-1-5):

[0073] In some embodiments, PBM represents the structures of Formula (PBM-2-1A), Formula (PBM-2-1B), Formula (PBM-2-1C), Formula (PBM-2-1D) or Formula (PBM-2-1E): wherein in Formula (PBM-2-1A), Formula (PBM-2-1B), Formula (PBM-2-1C), Formula (PBM-2-1D) and Formula (PBM-2-1E), (R 4< ) p3 each independently indicates that the benzene ring is substituted with p3 R 4< , with each R 4< being the same or different and independently representing halogen (e.g., fluorine, chlorine, bromine, or iodine), nitro, cyano, halogenated C 1-6 alkyl (e.g., halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), C 1-10 alkyl (e.g., C 1-8 alkyl, C 1-6 alkyl or C 1-4 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, hexyl, heptyl or octyl), deuterated C 1-10 alkyl (e.g., perdeuterated C 1-8 alkyl, perdeuterated C 1-6 alkyl or perdeuterated C 1-4 alkyl, such as CD 3 , CD 3 CD 2 -, CD 3 CD 2 CD 2 - etc.), C 1-10 alkoxy (e.g., C 1-8 alkoxy, C 1-6 alkoxy or C 1-4 alkoxy, such as methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy, or tert-butoxy) or -NHC(O)R 19a< , where R 19a< is C 1-10 alkyl (e.g., C 1-8 alkyl, C 1-6 alkyl or C 1-4 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, hexyl, heptyl or octyl), deuterated C 1-10 alkyl (e.g., perdeuterated C 1-8 alkyl, perdeuterated C 1-6 alkyl or perdeuterated C 1-4 alkyl, such as CD 3 , CD 3 CD 2 -, CD 3 CD 2 CD 2 - etc.) or C 2-10 alkenyl (e.g., C 2-6 alkenyl or C 2-4 alkenyl, such as vinyl, propenyl, butenyl or pentenyl), e.g., R 4< represents methyl, methoxy, nitro or p3 represents an integer of 1, 2, 3 or 4; (R 5< ) p4 each independently indicates that the 1H-indole ring is substituted with p4 R 5< , with each R 5< being the same or different and independently representing C 1-10 alkyl (e.g., C 1-8 alkyl, C 1-6 alkyl or C 1-4 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, hexyl, heptyl or octyl) or deuterated C 1-10 alkyl (e.g., perdeuterated C 1-8 alkyl, perdeuterated C 1-6 alkyl or perdeuterated C 1-4 alkyl, such as CD 3 , CD 3 CD 2 -, CD 3 CD 2 CD 2 - etc.); and p4 represents an integer of 0, 1, 2 or 3.

[0074] In some embodiments, PBM represents the structure of Formula (PBM-2-1) or Formula (PBM-2-2):

[0075] In some embodiments, PBM represents the structure of Formula (PBM-3-1A), Formula (PBM-3-1B), or Formula (PBM-3-1C): wherein in Formula (PBM-3-1A), Formula (PBM-3-1B) and Formula (PBM-3-1C), (R 7< ) p5 each independently indicates that the benzene ring is substituted with p5 R 7< , with each R 7< being the same or different and independently representing halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxy, C 1-6 alkyl (e.g., C 1-4 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 alkyl (e.g., halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), deuterated C 1-6 alkyl (e.g., perdeuterated C 1-6 alkyl or perdeuterated C 1-4 alkyl, such as CD 3 , CD 3 CD 2 -, CD 3 CD 2 CD 2 - etc.), NO 2 , NH 2 , or cyano; p5 represents an integer of 0, 1, 2, 3, 4 or 5; R 8< each independently represents substituted or unsubstituted C 3-15 cycloalkyl (e.g., substituted or unsubstituted C 3-10 cycloalkyl or C 3-6 cycloalkyl, such as cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl). In some embodiments, the C 3-15 cycloalkyl is optionally substituted with one or more (e.g., 1-3, 1, 2, or 3) substituents selected from the group consisting of deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C 1-6 alkyl, halogenated C 1-6 alkyl, optionally deuterated C 3-6 cycloalkyl, optionally deuterated C 1-6 alkoxy, optionally deuterated C 1-6 alkyl-NH-, NH 2 -C 1-6 alkylene, optionally deuterated C 1-6 alkyl-NHC(O)-, optionally deuterated C 1-6 alkyl-C(O)NH- or any combination thereof.

[0076] In some embodiments, PBM represents the structure of Formula (PBM-3-1):

[0077] In some embodiments, PBM represents the structure of Formula (PBM-4-1A), Formula (PBM-4-1B), Formula (PBM-4-1C) or Formula (PBM-4-1D): wherein in Formula (PBM-4-1A), Formula (PBM-4-1B), Formula (PBM-4-1C) and Formula (PBM-4-1D), (R 9< ) p6 each independently indicates that the benzene ring is substituted with p6 R 9< , with each R 9< being the same or different and independently representing halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxy, C 1-6 alkyl (e.g., C 1-6 alkyl, C 1-4 alkyl or C 1-3 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 alkyl (e.g., halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), deuterated C 1-6 alkyl (e.g., perdeuterated C 1-6 alkyl, perdeuterated C 1-5 alkyl or perdeuterated C 1-4 alkyl, such as CD 3 , CD 3 CD 2 -, CD 3 CD 2 CD 2 - etc.), NO 2 , NH 2 , C 1-6 alkoxy (e.g., C 1-5 alkoxy or C 1-4 alkoxy, such as methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy, or tert-butoxy), halogenated C 1-6 alkoxy (e.g., halogenated C 1-4 alkoxy, such as F 3 C-O-, FCH 2 -O-, F 2 CH-O-, ClCH 2 -O-, Cl 2 CH-O-, CF 3 CF 2 -O-, CF 3 CHF-O-, CHF 2 CF 2 -O-, CHF 2 CHF-O-, CF 3 CH 2 -O- or CH 2 ClCH 2 -O-), or cyano, p6 represents an integer of 2, 3, 4 or 5; and R 10< each independently represents C 6-10 aryl, or heteroaryl containing one or two 5- to 7-membered rings and 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulfur, wherein the C 6-10 aryl and heteroaryl are each optionally substituted with one or more (e.g., 1-6, such as 1, 2, 3, 4, 5 or 6) R b1< , with each R b1< being the same or different and independently representing halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxy, cyano, amino, nitro, C 1-6 alkyl (e.g., C 1-5 alkyl, C 1-4 alkyl or C 1-3 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 alkyl (e.g., halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), deuterated C 1-6 alkyl (e.g., perdeuterated C 1-6 alkyl, perdeuterated C 1-5 alkyl or perdeuterated C 1-4 alkyl, such as CD 3 , CD 3 CD 2 -, CD 3 CD 2 CD 2 - etc.), C 1-6 alkoxy (e.g., C 1-4 alkoxy, such as methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy, or tert-butoxy), or halogenated C 1-6 alkoxy (e.g., halogenated C 1-4 alkoxy, such as F 3 C-O-, FCH 2 -O-, F 2 CH-O-, ClCH 2 -O-, Cl 2 CH-O-, CF 3 CF 2 -O-, CF 3 CHF-O-, CHF 2 CF 2 -O-, CHF 2 CHF-O-, CF 3 CH 2 -O- or CH 2 ClCH 2 -O-).

[0078] In some embodiments, R 10< represents C 6-10 aryl, such as but not limited to phenyl or naphthyl, each of which is optionally substituted with one or more (e.g., 1-6, such as 1, 2, 3, 4, 5 or 6) R b1< as defined above.

[0079] In some embodiments, R 10< represents heteroaryl containing one or two 5- to 7-membered rings and 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulfur. In a sub-embodiment, R 10< represents 5- to 14-membered monocyclic or bicyclic aromatic ring group containing one or more (e.g., from 1 to 6, or from 1 to 5, or from 1 to 4, or from 1 to 3) heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur. In a sub-embodiment, examples of heteroaryl include, but are not limited to, furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzotriazolyl, benzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphthyridinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, pyrrolo[2,1-b]thiazolyl, imidazo[2,1-b]thiazolyl, or imidazo[1,2-b]pyridazinyl. The heteroaryl group is optionally substituted with one or more (e.g., 1-6, such as 1, 2, 3, 4, 5 or 6) R b1< as defined above.

[0080] In some embodiments, PBM represents the structure of Formula (PBM-4-1) or Formula (PBM-4-2):

[0081] In some embodiments, PBM represents the structure of Formula (PBM-5-1A), Formula (PBM-5-1B), Formula (PBM-5-1C) or Formula (PBM-5-1D): wherein in Formula (PBM-5-1A), Formula (PBM-5-1B), Formula (PBM-5-1C) and Formula (PBM-5-1D), (R 11< ) p7 each independently indicates that the benzene ring and the pyridine ring are each optionally substituted with p7 R 11< , with each p7 being the same or different and each independently representing an integer of 0, 1, 2 or 3, and each R 11< is the same or different and each independently represents halogen (e.g., fluorine, chlorine, bromine, or iodine), C 1-6 alkyl (e.g., C 1-5 alkyl, C 1-4 alkyl or C 1-3 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 alkyl (e.g., halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), or deuterated C 1-6 alkyl (e.g., perdeuterated C 1-6 alkyl, perdeuterated C 1-5 alkyl or perdeuterated C 1-4 alkyl, such as CD 3 , CD 3 CD 2 -, CD 3 CD 2 CD 2 - etc.); and R 12< each independently represents hydrogen, C 1-6 alkyl (e.g., C 1-5 alkyl, C 1-4 alkyl or C 1-3 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 alkyl (e.g., halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), or deuterated C 1-6 alkyl (e.g., perdeuterated C 1-6 alkyl, perdeuterated C 1-5 alkyl or perdeuterated C 1-4 alkyl, such as CD 3 , CD 3 CD 2 -, CD 3 CD 2 CD 2 - etc.).

[0082] In some embodiments, PBM represents the structure of Formula (PBM-5-1):

[0083] In some embodiments, PBM represents the structure of Formula (PBM-6): wherein R 13< represents hydrogen, C 1-10 alkyl (e.g., C 1-8 alkyl, C 1-6 alkyl or C 1-4 alkyl, such as methyl, ethyl, propyl, isopropyl( ), butyl, sec-butyl, tert-butyl, pentyl, hexyl, heptyl or octyl), deuterated C 1-10 alkyl (e.g., perdeuterated C 1-8 alkyl, perdeuterated C 1-6 alkyl or perdeuterated C 1-4 alkyl, such as CD 3 , CD 3 CD 2 -, CD 3 CD 2 CD 2 - etc.) or halogenated C 1-10 alkyl (e.g., halogenated C 1-8 alkyl or halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -); and R 14< represents wherein (R b2< ) p8 represents indicates that the piperidine ring is substituted with p8 R b2< , with each R b2< being the same or different and each independently representing deuterium, halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxy, C 1-6 alkyl (e.g., C 1-5 alkyl, C 1-4 alkyl or C 1-3 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 alkyl (e.g., halogenated C 1-5 alkyl or halogenated C 1-3 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), deuterated C 1-6 alkyl (e.g., perdeuterated C 1-6 alkyl, perdeuterated C 1-5 alkyl or perdeuterated C 1-4 alkyl, such as CD 3 , CD 3 CD 2 -, CD 3 CD 2 CD 2 - etc.), C 1-6 alkoxy (e.g., C 1-4 alkoxy, such as methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy, or tert-butoxy), halogenated C 1-6 alkoxy (e.g., halogenated C 1-4 alkoxy, such as F 3 C-O-, FCH 2 -O-, F 2 CH-O-, ClCH 2 -O-, Cl 2 CH-O-, CF 3 CF 2 -O-, CF 3 CHF-O-, CHF 2 CF 2 -O-, CHF 2 CHF-O-, CF 3 CH 2 -O- or CH 2 ClCH 2 -O-), deuterated C 1-6 alkoxy (e.g., perdeuterated C 1-4 alkoxy, such as CD 3 -O-, CD 3 CD 2 -O-, or CD 3 CD 2 CD 2 -O-), NO 2 , NH 2 , or cyano, p8 represents an integer of 1, 2, 3, 4 or 5.

[0084] In some embodiments, PBM represents the structure of Formula (PBM-6-1) or Formula (PBM-6-2):

[0085] In some embodiments, PBM represents the structure of Formula (PBM-49): wherein X 24 , X 25 , X 26 each independently represent CH or N; R 138< represents -C(O)NHR b19< , -NHC(O)-R b19< , -S(O) 2 NHR b19< , -NHS(O) 2 R b19< , -S(O) 2 R b19< or - P(O)(R b19< ) 2 , wherein each R b19< is the same or different and each independently represents C 1-6 alkyl (e.g., C 1-4 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl) or deuterated C 1-6 alkyl (e.g., perdeuterated C 1-5 alkyl, perdeuterated C 1-4 alkyl or perdeuterated C 1-3 alkyl, such as CD 3 , CD 3 CD 2 -, CD 3 CD 2 CD 2 - etc.); R 139< and R 140< each independently represent halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxy, cyano, amino, nitro, C 1-6 alkyl (e.g., C 1-4 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 alkyl (e.g., halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), deuterated C 1-6 alkyl (e.g., perdeuterated C 1-5 alkyl, perdeuterated C 1-4 alkyl or perdeuterated C 1-3 alkyl, such as CD 3 , CD 3 CD 2 -, CD 3 CD 2 CD 2 - etc.), C 1-6 alkoxy (e.g., C 1-5 alkoxy, C 1-4 alkoxy or C 1-3 alkoxy, such as methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy, or tert-butoxy), or halogenated C 1-6 alkoxy (e.g., halogenated C 1-4 alkoxy, such as trifluoromethoxy); (R 141< ) p50 indicates that the benzene ring is substituted with p50 R 141< , with each R 141< being independently halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxy, cyano, amino, nitro, C 1-6 alkyl (e.g., C 1-4 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 alkyl (e.g., halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), deuterated C 1-6 alkyl (e.g., perdeuterated C 1-5 alkyl, perdeuterated C 1-4 alkyl or perdeuterated C 1-3 alkyl, such as CD 3 , CD 3 CD 2 -, CD 3 CD 2 CD 2 - etc.), C 1-6 alkoxy (e.g., C 1-5 alkoxy, C 1-4 alkoxy or C 1-3 alkoxy, such as methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy, or tert-butoxy), or halogenated C 1-6 alkoxy (e.g., halogenated C 1-4 alkoxy, such as trifluoromethoxy); and p50 represents an integer of 0, 1, 2, 3 or 4.

[0086] In some embodiments, PBM represents the structure of Formula (PBM-49-1A), Formula (PBM-49-1B), Formula (PBM-49-1C) or Formula (PBM-49-1D): wherein in Formula (PBM-49-1A), Formula (PBM-49-1B), Formula (PBM-49-1C), Formula (PBM-49-1D) and Formula (PBM-49-1E), X 24 , X 25 , X 26 each independently represent CH or N; R 138< represents -C(O)NHR b19< , -NHC(O)-R b19< , -S(O) 2 NHR b19< , -NHS(O) 2 R b19< , -S(O) 2 R b19< or - P(O)(R bl9< ) 2 , wherein each R b19< is the same or different and each independently represents C 1-6 alkyl (e.g., C 1-4 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl) or deuterated C 1-6 alkyl (e.g., perdeuterated C 1-5 alkyl, perdeuterated C 1-4 alkyl or perdeuterated C 1-3 alkyl, such as CD 3 , CD 3 CD 2 -, CD 3 CD 2 CD 2 - etc.); R 139< and R 140< each independently represent halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxy, cyano, amino, nitro, C 1-6 alkyl (e.g., C 1-4 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 alkyl (e.g., halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), deuterated C 1-6 alkyl (e.g., perdeuterated C 1-5 alkyl, perdeuterated C 1-4 alkyl or perdeuterated C 1-3 alkyl, such as CD 3 , CD 3 CD 2 -, CD 3 CD 2 CD 2 - etc.), C 1-6 alkoxy (e.g., C 1-5 alkoxy, C 1-4 alkoxy or C 1-3 alkoxy, such as methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy, or tert-butoxy), or halogenated C 1-6 alkoxy (e.g., halogenated C 1-4 alkoxy, such as trifluoromethoxy); (R 14I< ) p50 indicates that the benzene ring is optionally substituted with p50 R 141< , with each R 141< being independently halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxy, cyano, amino, nitro, C 1-6 alkyl (e.g., C 1-4 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 alkyl (e.g., halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), deuterated C 1-6 alkyl (e.g., perdeuterated C 1-5 alkyl, perdeuterated C 1-4 alkyl or perdeuterated C 1-3 alkyl, such as CD 3 , CD 3 CD 2 -, CD 3 CD 2 CD 2 - etc.), C 1-6 alkoxy (e.g., C 1-5 alkoxy, C 1-4 alkoxy or C 1-3 alkoxy, such as methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy, or tert-butoxy), or halogenated C 1-6 alkoxy (e.g., halogenated C 1-4 alkoxy, such as trifluoromethoxy); and p50 represents an integer of 0, 1, 2, 3 or 4.

[0087] In some embodiments, X 24 and X 25 each independently represent CH or N. In some sub-embodiments, X 24 represents CH, and X 25 represents N. In some sub-embodiments, X 24 represents CH, and X 25 represents CH. In some sub-embodiments, X 24 represents N, and X 25 represents CH. In some sub-embodiments, X 24 represents N, and X 25 represents N.

[0088] In some embodiments, X 26 represents CH or N. In some sub-embodiments, X 26 represents N. In some sub-embodiments, X 26 represents CH.

[0089] In some embodiments, R 138< represents -C(O)NHR bl9< , -NHC(O)-R b19< , -S(O) 2 NHR b19< , - NHS(O) 2 R b19< , -S(O) 2 R b19< or -P(O)(R bl9< ) 2 , wherein each R bl9< is the same or different and each independently represents C 1-6 alkyl (e.g., C 1-4 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), or deuterated C 1-6 alkyl (e.g., perdeuterated C 1-5 alkyl, perdeuterated C 1-4 alkyl or perdeuterated C 1-3 alkyl, such as CD 3 , CD 3 CD 2 -, CD 3 CD 2 CD 2 - etc.). In some sub-embodiments, R 138< represents -P(O)(R bl9< ) 2 , wherein each R bl9< is the same or different and each independently represents C 1-6 alkyl (e.g., C 1-4 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), or deuterated C 1-6 alkyl (e.g., perdeuterated C 1-5 alkyl, perdeuterated C 1-4 alkyl or perdeuterated C 1-3 alkyl, such as CD 3 , CD 3 CD 2 -, CD 3 CD 2 CD 2 - etc.). In some sub-embodiments, R 138< represents -P(O)(CH 3 ) 2 .

[0090] In some embodiments, p50 represents an integer of 0, 1, 2, 3 or 4. In some sub-embodiments, p50 represents an integer of 2.

[0091] In some embodiments, PBM represents the structure of Formula (PBM-49-1), Formula (PBM-49-2), Formula (PBM-49-3), Formula (PBM-49-4) or Formula (PBM-49-5):

[0092] In some embodiments, PBM represents the structure of Formula (PBM-55): wherein R 157< represents C 6-1O aryl, or heteroaryl containing one or two 5- to 7-membered rings and 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulfur, wherein the C 6-1O aryl and heteroaryl are each optionally substituted with one or more (e.g., 1-6, such as 1, 2, 3, 4, 5 or 6) substituents selected from the group consisting of: halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxy, mercapto, cyano, amino, nitro, C 1-6 alkyl (e.g., C 1-5 alkyl, C 1-4 alkyl or C 1-3 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 alkyl (e.g., halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), deuterated C 1-6 alkyl (e.g., perdeuterated C 1-6 alkyl, perdeuterated C 1-5 alkyl or perdeuterated C 1-4 alkyl, such as CD 3 , CD 3 CD 2 -, CD 3 CD 2 CD 2 - etc.), C 1-6 alkoxy (e.g., C 1-4 alkoxy, such as methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy, or tert-butoxy), or halogenated C 1-6 alkoxy (e.g., halogenated C 1-4 alkoxy, such as F 3 C-O-, FCH 2 -O-, F 2 CH-O-, ClCH 2 -O-, Cl 2 CH-O-, CF 3 CF 2 -O-, CF 3 CHF-O-, CHF 2 CF 2 -O-, CHF 2 CHF-O-, CF 3 CH 2 -O- or CH 2 ClCH 2 -O-); R 158< represents 5- to 15-membered heteroaryl containing from 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulfur, wherein the 5- to 15-membered heteroaryl is optionally substituted with one or more substituents selected from the group consisting of: halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxy, mercapto, cyano, amino, nitro, C 1-6 alkyl (e.g., C 1-5 alkyl, C 1-4 alkyl or C 1-3 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 alkyl (e.g., halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), deuterated C 1-6 alkyl (e.g., perdeuterated C 1-6 alkyl, perdeuterated C 1-5 alkyl or perdeuterated C 1-4 alkyl, such as CD 3 , CD 3 CD 2 -, CD 3 CD 2 CD 2 - etc.), C 1-6 alkoxy (e.g., C 1-4 alkoxy, such as methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy, or tert-butoxy), or halogenated C 1-6 alkoxy (e.g., halogenated C 1-4 alkoxy, such as F 3 C-O-, FCH 2 -O-, F 2 CH-O-, ClCH 2 -O-, Cl 2 CH-O-, CF 3 CF 2 -O-, CF 3 CHF-O-, CHF 2 CF 2 -O-, CHF 2 CHF-O-, CF 3 CH 2 -O- or CH 2 ClCH 2 -O-); and (R 159< ) p61 indicates that the isoindolinone ring in Formula (PBM-55) is substituted with p61 R 159< , with each R 159< being the same or different and each independently representing halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxy, mercapto, cyano, amino, nitro, C 1-6 alkyl (e.g., C 1-5 alkyl, C 1-4 alkyl or C 1-3 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 alkyl (e.g., halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), deuterated C 1-6 alkyl (e.g., perdeuterated C 1-6 alkyl, perdeuterated C 1-5 alkyl or perdeuterated C 1-4 alkyl, such as CD 3 , CD 3 CD 2 -, CD 3 CD 2 CD 2 - etc.), C 1-6 alkoxy (e.g., C 1-4 alkoxy, such as methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy, or tert-butoxy), or halogenated C 1-6 alkoxy (e.g., halogenated C 1-4 alkoxy, such as F 3 C-O-, FCH 2 -O-, F 2 CH-O-, ClCH 2 -O-, Cl 2 CH-O-, CF 3 CF 2 -O-, CF 3 CHF-O-, CHF 2 CF 2 -O-, CHF 2 CHF-O-, CF 3 CH 2 -O- or CH 2 ClCH 2 -O-), and p61 represents an integer of 0, 1, 2 or 3.

[0093] In some embodiments, R 157< represents C 6-1O aryl, such as but not limited to phenyl or naphthyl, each of which is optionally substituted with one or more (e.g., 1-6, such as 1, 2, 3, 4, 5 or 6) substituents selected from the group consisting of: halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxy, mercapto, cyano, amino, nitro, C 1-6 alkyl (e.g., C 1-5 alkyl, C 1-4 alkyl or C 1-3 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 alkyl (e.g., halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), deuterated C 1-6 alkyl (e.g., perdeuterated C 1-6 alkyl, perdeuterated C 1-5 alkyl or perdeuterated C 1-4 alkyl, such as CD 3 , CD 3 CD 2 -, CD 3 CD 2 CD 2 - etc.), C 1-6 alkoxy (e.g., C 1-4 alkoxy, such as methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy, or tert-butoxy), or halogenated C 1-6 alkoxy (e.g., halogenated C 1-4 alkoxy, such as F 3 C-O-, FCH 2 -O-, F 2 CHO-, ClCH 2 -O-, Cl 2 CH-O-, CF 3 CF 2 -O-, CF 3 CHF-O-, CHF 2 CF 2 -O-, CHF 2 CHF-O-, CF 3 CH 2 -O- or CH 2 ClCH 2 -O-).

[0094] In some embodiments, R 157< represents heteroaryl containing one or two 5- to 7-membered rings and 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulfur. In a sub-embodiment, R 157< represents 5- to 15-membered monocyclic or bicyclic aromatic ring group containing one or more (e.g., from 1 to 6, or from 1 to 5, or from 1 to 4, or from 1 to 3) heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur. In a sub-embodiment, examples of heteroaryl include, but are not limited to, furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzotriazolyl, benzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphthyridinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, pyrrolo[2,1-b]thiazolyl, imidazo[2,1-b]thiazolyl, or imidazo[1,2-b]pyridazinyl. The heteroaryl group is optionally substituted with one or more (e.g., 1-6, such as 1, 2, 3, 4, 5 or 6) substituents selected from the group consisting of: halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxy, mercapto, cyano, amino, nitro, C 1-6 alkyl (e.g., C 1-5 alkyl, C 1-4 alkyl or C 1-3 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 alkyl (e.g., halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), deuterated C 1-6 alkyl (e.g., perdeuterated C 1-6 alkyl, perdeuterated C 1-5 alkyl or perdeuterated C 1-4 alkyl, such as CD 3 , CD 3 CD 2 -, CD 3 CD 2 CD 2 - etc.), C 1-6 alkoxy (e.g., C 1-4 alkoxy, such as methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy, or tert-butoxy), or halogenated C 1-6 alkoxy (e.g., halogenated C 1-4 alkoxy, such as F 3 C-O-, FCH 2 -O-, F 2 CH-O-, ClCH 2 -O-, Cl 2 CH-O-, CF 3 CF 2 -O-, CF 3 CHF-O-, CHF 2 CF 2 -O-, CHF 2 CHF-O-, CF 3 CH 2 -O- or CH 2 ClCH 2 -O-).

[0095] In some embodiments, R 158< represents 5- to 15-membered heteroaryl containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulfur. In a sub-embodiment, R 158< represents 5- to 15-membered monocyclic or bicyclic aromatic ring group containing from 1 to 4 (e.g., from 1 to 3, or from 1 to 2, or 1) heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur. In a sub-embodiment, examples of heteroaryl include, but are not limited to, 6,7-dihydro-5H-pyrrolo[l,2-c]imidazolyl, furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzotriazolyl, benzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphthyridinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, pyrrolo[2,1-b]thiazolyl, imidazo[2,1-b]thiazolyl, or imidazo[1,2-b]pyridazinyl. The heteroaryl group is optionally substituted with one or more (e.g., 1-6, such as 1, 2, 3, 4, 5 or 6) substituents selected from the group consisting of: halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxy, mercapto, cyano, amino, nitro, C 1-6 alkyl (e.g., C 1-5 alkyl, C 1-4 alkyl or C 1-3 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 alkyl (e.g., halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), deuterated C 1-6 alkyl (e.g., perdeuterated C 1-6 alkyl, perdeuterated C 1-5 alkyl or perdeuterated C 1-4 alkyl, such as CD 3 , CD 3 CD 2 -, CD 3 CD 2 CD 2 - etc.), C 1-6 alkoxy (e.g., C 1-4 alkoxy, such as methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy, or tert-butoxy), or halogenated C 1-6 alkoxy (e.g., halogenated C 1-4 alkoxy, such as F 3 C-O-, FCH 2 -O-, F 2 CH-O-, ClCH 2 -O-, Cl 2 CH-O-, CF 3 CF 2 -O-, CF 3 CHF-O-, CHF 2 CF 2 -O-, CHF 2 CHF-O-, CF 3 CH 2 -O- or CH 2 ClCH 2 -O-).

[0096] In some embodiments, PBM represents the structure of Formula (PBM-55-1) or Formula (PBM-55-2):

[0097] In some embodiments, PBM-R f - represents a small molecule ligand targeting AR.

[0098] In some embodiments, PBM represents the structure of Formula (PBM-7-1A): wherein ring A in (PBM-7-1A) represents C 6-1O aryl or 5- to 20-membered monocyclic or bicyclic heteroaryl containing from 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur, and (R b3< ) t3 indicates that ring A is optionally substituted with t3 R b3< , with each R b3< being the same or different and each independently representing deuterium, halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxy, cyano, amino, nitro, C 1-6 alkyl (e.g., C 1-5 alkyl, C 1-4 alkyl or C 1-3 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 alkyl (e.g., halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), deuterated C 1-6 alkyl (e.g., perdeuterated C 1-6 alkyl, perdeuterated C 1-5 alkyl or perdeuterated C 1-4 alkyl, such as CD 3 , CD 3 CD 2 -, CD 3 CD 2 CD 2 - etc.), C 1-6 alkoxy (e.g., C 1-4 alkoxy, such as methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy, or tert-butoxy), halogenated C 1-6 alkoxy (e.g., halogenated C 1-4 alkoxy, such as F 3 C-O-, FCH 2 -O-, F 2 CH-O-, ClCH 2 -O-, Cl 2 CH-O-, CF 3 CF 2 -O-, CF 3 CHF-O-, CHF 2 CF 2 -O-, CHF 2 CHF-O-, CF 3 CH 2 -O- or CH 2 ClCH 2 -O-), C 2-6 alkenyl (e.g., vinylvinyl, propenyl, or butenyl), or C 2-6 alkynyl (e.g., ethynyl, propynyl, or butynyl); ring B in Formula (PBM-7-1A) represents C 3-15 cycloalkyl or 3- to 20-membered heterocyclyl containing from 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur, and (R b4< ) t4 indicates that ring B is optionally substituted with t4 R b4< , with each R b4< being the same or different and each independently representing deuterium, halogen (e.g., fluorine, chlorine, bromine, or iodine), C 1-6 alkyl (e.g., C 1-5 alkyl, C 1-4 alkyl or C 1-3 alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 alkyl (e.g., halogenated C 1-4 alkyl, such as F 3 C-, FCH 2 -, F 2 CH-, ClCH 2 -, Cl 2 CH-, CF 3 CF 2 -, CF 3 CHF-, CHF 2 CF 2 -, CHF 2 CHF-, CF 3 CH 2 - or CH 2 ClCH 2 -), deuterated C 1-6 alkyl (e.g., perdeuterated C 1-6 alkyl, perdeuterated C 1-5 alkyl or perdeuterated C 1-4 alkyl, such as CD 3 , CD 3 CD 2 -, CD 3 CD 2 CD 2 - etc.), C 1-6 alkoxy (e.g., C 1-4 alkoxy, such as methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy, or tert-butoxy), or halogenated C 1-6 alkoxy (e.g., halogenated C 1-4 alkoxy, such as F 3 C-O-, FCH 2 -O-, F...

Claims

1. A compound of Formula (I) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof, wherein A represents CO, CH2 or CD2; R1, R2, R3 and R4 are the same or different and independently represent hydrogen, deuterium, halogen, optionally deuterated C1-6 alkyl, optionally deuterated C1-6 alkoxy, or halogenated C1-6 alkyl; (Ra)m indicates that benzene ring is substituted with m Ra substituents, with each Ra being the same or different and independently representing the structure of the following formula: wherein R represents chlorine, bromine, iodine, hydroxy, leaving group, NR7R8 or a group W1, wherein R7 and R8 are the same or different and independently represent hydrogen, C1-6 alkyl, C2-6 alkynyl-C1-6 alkylene-, C2-6 alkenyl-C1-6 alkylene-, optionally substituted 4- to 15-membered nitrogen-containing heterocyclyl, or R2a-R1a-, where R1a is optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, R2a represents halogen, amino, hydroxy, carboxyl, C2-6 alkynyl, C2-6 alkenyl or a leaving group; and W1 represents the structure of the following formula: wherein ring W2 represents optionally substituted nitrogen-containing heterocyclyl, each ring W3 is the same or different and independently represents optionally substituted nitrogen-containing heterocyclylene, t represents an integer of 1 or 2, and ring W4 represents optionally substituted aryl, optionally substituted heteroaryl or optionally substituted heterocyclyl; R5 and R6 are the same or different and independently represent hydrogen, fluorine, chlorine, bromine, iodine, optionally substituted methyl, or optionally substituted linear or branched C2-30 alkyl, wherein one or more groups Re and / or one or more groups Rd and / or any combination of one or more groups Rc and Rd are optionally inserted into the backbone carbon chain of the linear or branched C2-30 alkyl group, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group Rc, Rd, or a combination of Rc and Rd; wherein each Rc is selected from the group consisting of O, N(Re), C(O), C(O)O, S(O), S(O)2, S(O)2NH, NHS(O)2, OC(O), C(O)N(Re), N(Re)C(O), or N(Re)C(O)N(Re), where each Re independently represents H or C1-6 alkyl, and in case that two or more groups Rc are inserted into the backbone carbon chain of the linear or branched C2-30 alkyl group, the two or more groups Rc are not directly connected to each other; and wherein each Rd is selected from the group consisting of cycloalkylene, arylene, heterocyclylene, heteroarylene, alkynylene, alkenylene, or any combination thereof, wherein the cycloalkylene, arylene, heterocyclylene, and heteroarylene are independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, halogenated C1-6 alkyl, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, or any combination thereof; or R and R5, together with the carbon atom to which they are connected, form carbonyl group, R6 represents hydrogen, optionally substituted methyl, or optionally substituted linear or branched C2-30 alkyl, wherein one or more groups Rc and / or one or more groups Rd and / or any combination of one or more groups Rc and Rd are optionally inserted into the backbone carbon chain of the linear or branched C2-30 alkyl group, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group Rc, Rd, or a combination of Rc and Rd; wherein each Rc is selected from the group consisting of O, N(Re), C(O), C(O)O, S(O), S(O)2, S(O)2NH, NHS(O)2, OC(O), C(O)N(Re), N(Re)C(O), or N(Re)C(O)N(Re), where each Re independently represents H or C1-6 alkyl, and in case that two or more groups Rc are inserted into the backbone carbon chain of the linear or branched C2-30 alkyl group, the two or more groups Rc are not directly connected to each other; and wherein each Rd is selected from the group consisting of cycloalkylene, arylene, heterocyclylene, heteroarylene, alkynylene, alkenylene, or any combination thereof, wherein the cycloalkylene, arylene, heterocyclylene, and heteroarylene are independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, halogenated C1-6 alkyl, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, cyano, or any combination thereof; (Rb)n indicates that the benzene ring is substituted with n Rb substituents, with each Rb being the same or different and independently representing deuterium, halogen, hydroxy, mercapto, nitro, amino, cyano, optionally deuterated C1-6 alkyl, optionally deuterated C1-6 alkoxy, halogenated C1-6 alkyl, optionally substituted C3-6 cycloalkyl, C2-6 alkenyl or C2-6 alkynyl; and m represents an integer of 1, 2, 3, or 4, n represents an integer of 0, 1, 2, or 3, and the sum of m and n is an integer of 1, 2, 3, or 4; wherein when R and R5 together with the carbon atom to which they are connected form a carbonyl group and R6 represents hydrogen, m represents an integer of 1, 2, or 3, n represents an integer of 1, 2, or 3, and the sum of m and n is an integer of 2, 3, or 4; with the proviso that the following compounds and compounds of Formula (I') are excluded: and when A represents CH2 or C(O) and R represents unsubstituted piperazinyl, m represents an integer of 1 and n represents an integer of 0; when A represents CH2 or C(O) and Ra represents H2N-CH2-, m represents an integer of 1 and n represents an integer of 0; when A represents C(O) and R represents bromine, m represents an integer of 1 and n represents an integer of 0; and the compounds of Formula (I'): wherein in Formula (I'), A represents CH2 or C(O), and R represents unsubstituted piperidinyl or methylamino substituted piperidinyl.

2. The compound of Formula (I) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 1, wherein the compound of Formula (I) is also of Formula (I-1) or Formula (I-2): wherein A, R1, R2, R3, R4, Ra, Rb, m, and n are as defined in claim 1.

3. The compound of Formula (I) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 1 or 2, wherein R represents: chlorine, bromine, iodine, hydroxy, or leaving group; or NR7R8, wherein R7 and R8 are the same or different and each independently represent hydrogen, C1-6 alkyl, C2-6 alkynyl-C1-6 alkylene, C2-6 alkenyl-C1-6 alkylene, optionally substituted 4- to 15-membered nitrogen-containing monocyclic heterocyclyl, optionally substituted 4- to 15-membered nitrogen-containing bridged heterocyclyl, optionally substituted 4- to 15-membered nitrogen-containing spiro-heterocyclyl, or R2a-R1a-, wherein R1a represents optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, R2a represents halogen, amino, hydroxy, carboxyl, CHO, C2-6 alkynyl, C2-6 alkenyl or leaving group, and the 4- to 15-membered nitrogen-containing monocyclic heterocyclyl, the 4- to 15-membered nitrogen-containing bridged heterocyclyl, and the 4- to 15-membered nitrogen-containing spiro-heterocyclyl are each optionally substituted with one or more substituents selected from the group consisting of deuterium, C1-6 alkyl, C1-6 alkoxy, halogen, leaving group, amino, hydroxy, carboxyl, CHO, C2-6 alkynyl, C2-6 alkenyl, R4a-R3a-, or any combination thereof, where R3a represents optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, R4a represents halogen, R5aR6aN-, hydroxy, carboxyl, CHO, ethynyl, vinyl, or leaving group, wherein R5a and R6a are the same or different and each independently represent hydrogen or C1-3 alkyl; or mercapto, cyano, optionally deuterated C1-6 alkyl-NH-, halogenated C1-6 alkyl, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, or any combination thereof; W1 represented by the structure of the following formula: wherein ring W2 represents 4- to 20-membered nitrogen-containing heterocyclyl, (Ra1)m1 indicates that ring W2 is optionally substituted with m1 Ra1 substituents, with each Ra1 independently representing deuterium, optionally deuterated C1-6 alkyl, C1-6 alkoxy, halogen, leaving group, amino, hydroxy, mercapto, cyano, carboxyl, CHO, C2-6 alkynyl, C2-6 alkenyl, optionally deuterated C3-6 cycloalkyl, or R8a-R7a-, where R7a is optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, and R8a represents halogen, R9aR10aN-, hydroxy, carboxyl, CHO, ethynyl, vinyl, or leaving group, wherein R9a and R10a are the same or different and each independently represent hydrogen or C1-3 alkyl; or wherein each ring W3 is the same or different and independently represents 4- to 20-membered nitrogen-containing heterocyclylene, t represents an integer of 1 or 2, (Ra2)m2 indicates that each ring W3 is optionally substituted with m2 Ra2 substituents, with each Ra2 independently representing deuterium, optionally deuterated C1-6 alkyl, C1-6 alkoxy, halogen, leaving group, amino, hydroxy, mercapto, cyano, carboxyl, CHO, C2-6 alkynyl, C2-6 alkenyl, optionally deuterated C3-6 cycloalkyl, or R12a-R11a-, where R11a is optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, and R12a represents halogen, R13aR14aN-, hydroxy, carboxyl, CHO, ethynyl, vinyl, or leaving group, wherein R13a and R14a are the same or different and each independently represent hydrogen or C1-3 alkyl; and ring W4 represents 4- to 15-membered nitrogen-containing heterocyclyl, 6- to 10-membered aryl, or 5- to 10-membered heteroaryl, (Ra3)m3 indicates that ring W4 is optionally substituted with m3 Ra3 substituents, and each Ra3 independently represents deuterium, optionally deuterated C1-6 alkyl, C1-6 alkoxy, halogen, leaving group, amino, hydroxy, mercapto, cyano, carboxyl, CHO, C2-6 alkynyl, C2-6 alkenyl, optionally deuterated C3-6 cycloalkyl, or R16a-R15a-, where R15a is optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, and R16a represents halogen, R17aR18aN-, hydroxy, carboxyl, CHO, ethynyl, vinyl, or leaving group, wherein R17a and R18a are the same or different and each independently represent hydrogen or C1-3 alkyl; wherein m1, m2, and m3 independently represent an integer of 0-20.

4. The compound of Formula (I) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 1 or 2, wherein R represents NR7R8, where R7 and R8 are the same or different and each independently represent: hydrogen, C1-6 alkyl, C2-6 alkynyl-C1-6 alkylene, C2-6 alkenyl-C1-6 alkylene; or optionally substituted 4- to 15-membered nitrogen-containing monocyclic heterocyclyl, optionally substituted 4- to 15-membered nitrogen-containing bridged heterocyclyl, or optionally substituted 4- to 15-membered nitrogen-containing spiro-heterocyclyl, e.g., piperidinyl, piperazinyl, morpholinyl, azetidinyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, oxazolidinyl, thiazolidinyl, thiomorpholinyl, azepanyl, diazacycloheptanyl, azacyclooctyl, diazacyclooctyl, azabicyclo[3.1.1]heptanyl, azabicyclo[2.2.1]heptanyl, azabicyclo[3.2.1]octanyl, azabicyclo[2.2.2]octanyl, diazabicyclo[3.1.1]heptanyl, diazabicyclo[2.2.1]heptanyl, diazabicyclo[3.2.1]octanyl, diazabicyclo[2.2.2]octanyl, 3-azaspiro[5.5]undecan-3-yl, 8-azaspiro[4.5]decan-4-yl, 2-oxa-8-azaspiro[4.5]decan-4-yl, or 3-methyl-2-oxa-8-azaspiro[4.5]decan-4-yl, or or R2a-R1a-, where R1a represents optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, and R2a represents halogen, amino, hydroxy, carboxyl, CHO, C2-6 alkynyl, C2-6 alkenyl, or leaving group, wherein the 4- to 15-membered nitrogen-containing monocyclic heterocyclyl, the 4- to 15-membered nitrogen-containing bridged heterocyclyl and the 4- to 15-membered nitrogen-containing spiro-heterocyclyl are each optionally substituted with one or more substituents selected from the group consisting of deuterium, C1-6 alkyl, C1-6 alkoxy, halogen, leaving group, amino, hydroxy, carboxyl, CHO, C2-6 alkynyl, C2-6 alkenyl, R4a-R3a-, or any combination thereof, where R3a represents optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, R4a represents halogen, R5aR6aN-, hydroxy, carboxyl, CHO, ethynyl, vinyl, or leaving group, wherein R5a and R6a are the same or different and each independently represent hydrogen or C1-3 alkyl; or R represents W1 represented by the structure of the following formula: wherein ring W2 represents 4- to 20-membered nitrogen-containing heterocyclyl, e.g., piperidinyl, piperazinyl, morpholinyl, azetidinyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, oxazolidinyl, thiazolidinyl, thiomorpholinyl, azepanyl, diazacycloheptanyl, azacyclooctyl, diazacyclooctyl, azabicyclo[3.1.1]heptanyl, azabicyclo[2.2.1]heptanyl, azabicyclo[3.2.1]octanyl, azabicyclo[2.2.2]octanyl, diazabicyclo[3.1.1]heptanyl, diazabicyclo[2.2.1]heptanyl, diazabicyclo[3.2.1]octanyl, diazabicyclo[2.2.2]octanyl, 3-azaspiro[5.5]undecan-3-yl, 8-azaspiro[4.5]decan-4-yl, 2-oxa-8-azaspiro[4.5]decan-4-yl, or 3-methyl-2-oxa-8-azaspiro[4.5]decan-4-yl, or (Ra1)m1 indicates that ring W2 is optionally substituted with m1 Ra1 substituents, with each Ra1 independently representing deuterium, optionally deuterated C1-6 alkyl, C1-6 alkoxy, halogen, leaving group, amino, hydroxy, mercapto, cyano, carboxyl, CHO, C2-6 alkynyl, C2-6 alkenyl, optionally deuterated C3-6 cycloalkyl, or R8a-R7a-, where R7a is optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, and R8a represents halogen, R9aR10aN-, hydroxy, carboxyl, CHO, ethynyl, vinyl, or leaving group, wherein R9a and R10a are the same or different and each independently represent hydrogen or C1-3 alkyl; or W1 represented by the structure of the following formula: wherein each ring W3 is the same or different and independently represents 4- to 20-membered nitrogen-containing heterocyclylene, e.g., piperidinylene, piperazinylene, morpholinylene, azetidinylene, pyrrolidinylene, imidazolidylene, pyrazolidylene, oxazolidinylene, thiazolidinylene, thiomorpholinylene, azepanylene, diazacycloheptanylene, azacyclooctylene, diazacyclooctylene, azabicyclo[3.1.1]heptanylene, azabicyclo[2.2.1]heptanylene, azabicyclo[3.2.1]octanylene, azabicyclo[2.2.2]octanylene, diazabicyclo[3.1.1]heptanylene, diazabicyclo[2.2.1]heptanylene, diazabicyclo[3.2.1]octanylene, diazabicyclo[2.2.2]octanylene, 3-azaspiro[5.5]undecan-3-ylene, 8-azaspiro[4.5]decan-4-ylene, 2-oxa-8-azaspiro[4.5]decan-4-ylene, or 3-methyl-2-oxa-8-azaspiro[4.5]decan-4-ylene, or t represents an integer of 1 or 2, (Ra2)m2 indicates that each ring W3 is optionally substituted with m2 Ra2 substituents, with each Ra2 independently representing deuterium, optionally deuterated C1-6 alkyl, C1-6 alkoxy, halogen, leaving group, amino, hydroxy, mercapto, cyano, carboxyl, CHO, C2-6 alkynyl, C2-6 alkenyl, optionally deuterated C3-6 cycloalkyl, or R12a-R11a-, where R11a is optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, and R12a represents halogen, R13aR14aN-, hydroxy, carboxyl, CHO, ethynyl, vinyl, or leaving group, wherein R13a and R14a are the same or different and each independently represent hydrogen or C1-3 alkyl; and ring W4 represents 4- to 15-membered nitrogen-containing heterocyclyl, 6- to 10-membered aryl, or 5- to 10-membered heteroaryl, e.g., piperidinyl, piperazinyl, morpholinyl, azetidinyl, pyrrolidinyl, imidazolidinyl, pyrazolidyl, oxazolidinyl, thiazolidinyl, thiomorpholinyl, azepanyl, diazacycloheptanyl, azacyclooctyl, diazacyclooctyl, azabicyclo[3.1.1]heptanyl, azabicyclo[2.2.1]heptanyl, azabicyclo[3.2.1]octanyl, azabicyclo[2.2.2]octanyl, diazabicyclo[3.1.1]heptanyl, diazabicyclo[2.2.1]heptanyl, diazabicyclo[3.2.1]octanyl, diazabicyclo[2.2.2]octanyl, 3-azaspiro[5.5]undecan-3-yl, 8-azaspiro[4.5]decan-4-yl, 2-oxa-8-azaspiro[4.5]decan-4-yl, 3-methyl-2-oxa-8-azaspiro[4.5]decan-4-yl, phenyl, naphthyl, furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzotriazolyl, benzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphthyridinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, pyrrolo[2,1-b]thiazolyl, or imidazo[2,1-b]thiazolyl; or (Ra3)m3 indicates that ring W4 is optionally substituted with m3 Ra3 substituents, with each Ra3 independently representing deuterium, optionally deuterated C1-6 alkyl, C1-6 alkoxy, halogen, leaving group, amino, hydroxy, mercapto, cyano, carboxyl, CHO, C2-6 alkynyl, C2-6 alkenyl, optionally deuterated C3-6 cycloalkyl, or R16a-R15a-, where R15a is optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, and R16a represents halogen, R17aR18aN-, hydroxy, carboxyl, CHO, ethynyl, vinyl, or leaving group, wherein R17a and R18a are the same or different and each independently represent hydrogen or C1-3 alkyl; wherein m1, m2, and m3 each independently represent an integer of 0-20.

5. The compound of Formula (I) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 1, wherein R represents the following groups: chlorine, bromine, iodine, hydroxy, -N3, sulfonate, e.g., methanesulfonyloxy (MsO-), trifluoromethanesulfonyloxy (TfO-), p-toluenesulfonyloxy (TsO-), NH2, or or 6. The compound of Formula (I) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 1 or 2, wherein R5 and R6 each independently represent: hydrogen, fluorine, chlorine, bromine, iodine, optionally substituted methyl, or optionally substituted linear or branched C2-30 alkyl, wherein one or more groups Rc and / or one or more groups Rd and / or any combination of one or more groups Rc and Rd are optionally inserted into the backbone carbon chain of the linear or branched C2-30 alkyl group, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group Rc, Rd, or a combination of Rc and Rd; wherein each Rc is selected from the group consisting of O, N(Re), C(O), C(O)O, S(O), S(O)2, S(O)2NH, NHS(O)2, OC(O), C(O)N(Re), N(Re)C(O), or N(Re)C(O)N(Re), where each Re independently represents H or C1-6 alkyl, and in case that two or more groups Rc are inserted into the backbone carbon chain of the linear or branched C2-30 alkyl group, the two or more groups Rc are not directly connected to each other; and wherein each Rd is selected from the group consisting of cycloalkylene (e.g., C3-20 cycloalkylene), arylene (e.g., C3-20 arylene), heterocyclylene (e.g., 4- to 20-membered heterocyclylene), heteroarylene (e.g., 4- to 20-membered heteroarylene), alkynylene (e.g., C2-6 alkynylene), alkenylene (e.g., C2-6 alkenylene), or any combination thereof, wherein the cycloalkylene, arylene, heterocyclylene, and heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, halogenated C1-6 alkyl, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, cyano, or any combination thereof; and a hydrogen atom of methyl and hydrogen atom of one or more CH2 of C2-30 alkyl are optionally substituted with a substituent selected from the group consisting of deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C1-6 alkyl, halogenated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, or any combination thereof.

7. The compound of Formula (I) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 1, wherein R and R5 together with the carbon atom to which they are connected form carbonyl group.

8. The compound of Formula (I) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in any one of claims 1-2 and 6-7, wherein R6 represents the structure of the following formula: -C1-30 alkyl; -(C(Ra4)(Ra5))n1-(Rc-(C(Ra6)(Ra7))n2)m4-H; -(C(Ra4)(Ra5))n1-(Rc-(C(Ra6)(Ra7))n2)m4-(Rc-(C(Ra8)(Ra9))n3)m5-H; -(C(Ra4)(Ra5))n1-(Rc-(C(Ra6)(Ra7))n2)m4-(Rc-(C(Ra8)(Ra9))n3)m5-(Rc-(C(Ra10)(Ra11))n4)m6-H; -(C(Ra4)(Ra5))n1-(Rd-(C(Ra6)(Ra7))n2)m4-H; -(C(Ra4)(Ra5))n1-(Rd-(C(Ra6)(Ra7))n2)m4-(Rd-(C(Ra8)(Ra9))n3)m5-H; -(C(Ra4)(Ra5))n1-(Rd-(C(Ra6)(Ra7))n2)m4-(Rd-(C(Ra8)(Ra9))n3)m5-(Rd-(C(Ra10)(Ra11))n4)m6-H; -(C(Ra4)(Ra5))n1-(Rc-Rd-(C(Ra6)(Ra7))n2)m4-H; -(C(Ra4)(Ra5))n1-(Rc-(C(Ra6)(Ra7))n2)m4-(Rd-(C(Ra8)(Ra9))n3)m5-H; -(C(Ra4)(Ra5))n1-(Rd-Rc-(C(Ra6)(Ra7))n2)m4-H; or -(C(Ra4)(Ra5))n1-(Rd-(C(Ra6)(Ra7))n2)m4-(Rc-(C(Ra8)(Ra9))n3)m5-H; wherein each Rc is selected from the group consisting of O, N(Re), C(O), C(O)O, OC(O), S(O), S(O)2, S(O)2NH, NHS(O)2, C(O)N(Re), N(Re)C(O), or N(Re)C(O)N(Re), where each Re independently represents H or C1-6 alkyl; and wherein each Rd is selected from the group consisting of cycloalkylene (e.g., C3-20 cycloalkylene), arylene (e.g., C5-20 arylene), heterocyclylene (e.g., 4- to 20-membered heterocyclylene), heteroarylene (e.g., 5- to 20-membered heteroarylene), alkynylene (e.g., C2-6 alkynylene), alkenylene (e.g., C2-6 alkenylene), or any combination thereof, wherein the cycloalkylene, arylene, heterocyclylene, and heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, halogenated C1-6 alkyl, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, cyano, or any combination thereof; a hydrogen atom of one or more CH2 of C1-30 alkyl is optionally substituted with a substituent selected from the group consisting of deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C1-6 alkyl, halogenated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, or any combination thereof; Ra4, Ra5, Ra6, Ra7, Ra8, Ra9, Ra10 and Ra11 each independently represent H, deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C1-6 alkyl, halogenated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, or optionally deuterated C1-6 alkyl-C(O)NH-; and n1, n2, n3, n4, m4, m5, and m6 each independently represent an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

9. The compound of Formula (I) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 8, wherein R6 represents the structure of the following formula: -(C(Ra4)(Ra5))n1-(O-(C(Ra6)(Ra7))n2)m4-H; -(C(Ra4)(Ra5))n1-(O-(C(Ra6)(Ra7))n2)m4-(O-(C(Ra8)(Ra9))n3)m5-H; -(C(Ra4)(Ra5))n1-(O-(C(Ra6)(Ra7))n2)m4-(O-(C(Ra8)(Ra9))n3)m5-(O-(C(Ra10)(Ra11))n4)m6-H; -(C(Ra4)(Ra5))n1-(N(Re)-(C(Ra6)(Ra7))n2)m4-H; -(C(Ra4)(Ra5))n1-(N(Re)-(C(Ra6)(Ra7))n2)m4-(N(Re)-(C(Ra8)(Ra9))n3)m5-H; -(C(Ra4)(Ra5))n1-(N(Re)-(C(Ra6)(Ra7))n2)m4-(N(Re)-(C(Ra8)(Ra9))n3)m5-(N(Re)-(C(Ra10)(Ra11))n4)m6-H; -(C(Ra4)(Ra5))n1-(C(O)N(Re)-(C(Ra6)(Ra7))n2)m4-H; -(C(Ra4)(Ra5))n1-(C(O)N(Re)-(C(Ra6)(Ra7))n2)m4-(C(O)N(Re)-(C(Ra8)(Ra9))n3)m5-H; -(C(Ra4)(Ra5))n1-(C(O)N(Re)-(C(Ra6)(Ra7))n2)m4-(C(O)N(Re)-(C(Ra8)(Ra9))n3)m5-(C(O)N(Re)-(C(Ra10)(Ra11))n4)m6-H; -(C(Ra4)(Ra5))n1-(C(O)N(Re)-(C(Ra6)(Ra7))n2)m4-(O-(C(Ra8)(Ra9))n3)m5-H; -(C(Ra4)(Ra5))n1-C(O)N(Re)-(C(Ra6)(Ra7))n2-(O-(C(Ra8)(Ra9))n3)m4-H; -(C(Ra4)(Ra5))n1-(N(Re)C(O)-(C(Ra6)(Ra7))n2)m4-H; -(C(Ra4)(Ra5))n1-(N(Re)C(O)-(C(Ra6)(Ra7))n2)m4-(O-(C(Ra8)(Ra9))n3)m5-H; -(C(Ra4)(Ra5))n1-(N(Re)C(O)-(C(Ra6)(Ra7))n2)m4-(O-(C(Ra8)(Ra9))n3)m5-(O-(C(Ra10)(Ra11))n4)m6-H; -(C(Ra4)(Ra5))n1-N(Re)C(O)-(C(Ra6)(Ra7))n2-(O-(C(Ra8)(Ra9))n3)m4-H; -(C(Ra4)(Ra5))n1-N(Re)C(O)N(Re)-(C(Ra6)(Ra7))n2-H; -(C(Ra4)(Ra5))n1-C(O)-(C(Ra6)(Ra7))n2-H; -(C(Ra4)(Ra5))n1-arylene-(C(Ra6)(Ra7))n2)m4-H; -(C(Ra4)(Ra5))n1-(arylene(C(Ra6)(Ra7))n2)m4-arylene-(C(Ra8)(Ra9))n3-H; -(C(Ra4)(Ra5))n1-(heterocyclylene-(C(Ra6)(Ra7))n2)m4-H; -(C(Ra4)(Ra5))n1-(heterocyclylene-(C(Ra6)(Ra7))n2)m4-(heterocyclylene-(C(Ra8)(Ra9))n3)m5-H; -(C(Ra4)(Ra5))n1-(heteroarylene-(C(Ra6)(Ra7))n2)m4-H; -(C(Ra4)(Ra5))n1-(heteroarylene-(C(Ra6)(Ra7))n2)m4-(heteroarylene-(C(Ra8)(Ra9))n3)m5-H; -(C(Ra4)(Ra5))n1-(cycloalkylene-(C(Ra6)(Ra7))n2)m4-H; or -(C(Ra4)(Ra5))n1-(cycloalkylene-(C(Ra6)(Ra7))n2)m4-(cycloalkylene-(C(Ra8)(Ra9))n3)m5-H; wherein each Re independently represents H or C1-6 alkyl; the cycloalkylene, arylene, heterocyclylene and heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, halogenated C1-6 alkyl, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, cyano, or any combination thereof; Ra4, Ra5, Ra6, Ra7, Ra8, Ra9, Ra10 and Ra11 each independently represent H, deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C1-6 alkyl, halogenated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, or optionally deuterated C1-6 alkyl-C(O)NH-; and n1, n2, n3, n4, m4, m5, and m6 each independently represent an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

10. The compound of Formula (I) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 1, wherein R6 represents the following group: H, fluorine, chlorine, bromine, iodine, -CH3, -CH2-CH3, -(CH2)2-CH3, -(CH2)3-CH3, -(CH2)4-CH3, -(CH2)5-CH3, -(CH2)6-CH3, -(CH2)7-CH3, -(CH2)8-CH3, -(CH2)9-CH3, -(CH2)10-CH3, -(CH2)11-CH3, - (CH2)12-CH3, -(CH2)13-CH3, -(CH2)14-CH3, -(CH2)15-CH3, -(CH2)16-CH3, -(CH2)17-CH3, -(CH2)18-CH3, -(CH2)19-CH3, -(CH2)20-CH3, -(CH2)21-CH3, -(CH2)22-CH3, -(CH2)25-CH3, -(CH2)29-CH3;-CH2-O-CH3, -CH2-O-CH2-CH3, -CH2-O-(CH2)2-CH3, -(CH2)1-O-(CH2)3-CH3, -(CH2)1-O-(CH2)4-CH3, -(CH2)1-O- (CH2)5-CH3, -(CH2)1-O-(CH2)6-CH3, -(CH2)1-O-(CH2)7-CH3, -(CH2)1-O-(CH2)8-CH3, -(CH2)1-O- (CH2)9-CH3, -(CH2)1-O-(CH2)10-CH3, -(CH2)2-O-CH3, -(CH2)2-O-CH2-CH3, -(CH2)2-O-(CH2)2-CH3, - (CH2)2-O-(CH2)3-CH3, -(CH2)2-O-(CH2)4-CH3, -(CH2)2-O-(CH2)5-CH3, -(CH2)2-O-(CH2)6-CH3, - (CH2)2-O-(CH2)7-CH3, -(CH2)2-O-(CH2)8-CH3, -(CH2)2-O-(CH2)9-CH3, -(CH2)2-O-(CH2)10-CH3, - (CH2)2-O-(CH2)11-CH3, -(CH2)2-O-(CH2)12-CH3, -(CH2)3-O-CH3, -(CH2)3-O-CH2-CH3, -(CH2)3-O-(CH2)2-CH3, -(CH2)3-O-(CH2)3-CH3, -(CH2)3-O-(CH2)4-CH3, -(CH2)3-0-(CH2)5-CH3, -(CH2)3-O-(CH2)6-CH3, -(CH2)3-O-(CH2)7-CH3, -(CH2)4-O-CH3, -(CH2)4-O-CH2-CH3, -(CH2)4-O-(CH2)2-CH3, - (CH2)4-O-(CH2)3-CH3, -(CH2)4-O-(CH2)4-CH3, -(CH2)4-O-(CH2)5-CH3, -(CH2)4-O-(CH2)6-CH3, - (CH2)5-O-CH3, -(CH2)5-O-CH2-CH3, -(CH2)5-O-(CH2)2-CH3, -(CH2)5-O-(CH2)3-CH3, -(CH2)5-O-(CH2)4-CH3, -(CH2)5-O-(CH2)5-CH3, -(CH2)6-O-CH3, -(CH2)6-O-CH2-CH3, -(CH2)6-O-(CH2)2-CH3, - (CH2)6-O-(CH2)3-CH3, -(CH2)6-O-(CH2)4-CH3, -(CH2)7-O-CH3, -(CH2)7-O-CH2-CH3, -(CH2)7-O-(CH2)2-CH3, -(CH2)7-O-(CH2)3-CH3, -(CH2)8-O-CH3, -(CH2)8-O-CH2-CH3, -(CH2)8-O-(CH2)2-CH3, - CH(CH3)-O-CH3, -CH(CH3)-O-CH2-CH3, -CH(CH3)-O-(CH2)2-CH3, -CH(CH3)-O-(CH2)3-CH3, - CH(CH3)-O-(CH2)4-CH3, -CH(CH3)-O-(CH2)5-CH3, -CH(CH3)-O-(CH2)6-CH3, -CH(CH3)-O-(CH2)7-CH3, -CH(CH3)-O-(CH2)8-CH3, -CH(CH3)-O-(CH2)9-CH3, -CH(CH3)-O-(CH2)10-CH3, -CH2-(O(CH2)2)1-OCH2CH3, -CH2-(O(CH2)2)2-OCH2CH3, -CH2-(O(CH2)2)3-OCH2CH3, -CH2-(O(CH2)2)4-OCH2CH3, -CH2-(O(CH2)2)5-OCH2CH3, -CH2-(O(CH2)2)6-OCH2CH3, -CH2-(O(CH2)2)7-OCH2CH3, - CH2-(O(CH2)2)8-OCH2CH3, -CH2-(O(CH2)2)9-OCH2CH3, -CH2-(O(CH2)2)10-OCH2CH3, -CH2-(O(CH2)2)1-OCH3, -CH2-(O(CH2)2)2-OCH3, -CH2-(O(CH2)2)3-OCH3, -CH2-(O(CH2)2)4-OCH3, -CH2-(O(CH2)2)5-OCH3, -CH2-(O(CH2)2)6-OCH3, -CH2-(O(CH2)2)7-OCH3, -CH2-(O(CH2)2)8-OCH3, -CH2-(O(CH2)2)9-OCH3, -CH2-(O(CH2)2)10-OCH3, -(CH2)2-(O(CH2)2)1-OCH2CH3, -(CH2)2-(O(CH2)2)2-OCH2CH3, -(CH2)2-(O(CH2)2)3-OCH2CH3, -(CH2)2-(O(CH2)2)4-OCH2CH3, -(CH2)2-(O(CH2)2)5-OCH2CH3, -(CH2)2-(O(CH2)2)6-OCH2CH3, -(CH2)2-(O(CH2)2)7-OCH2CH3, -(CH2)2-(O(CH2)2)8-OCH2CH3, -(CH2)2-(O(CH2)2)9-OCH2CH3, -(CH2)2-(O(CH2)2)10-OCH2CH3, -(CH2)3-(O(CH2)2)1-OCH2CH3, -(CH2)3-(O(CH2)2)2-OCH2CH3, -(CH2)3-(O(CH2)2)3-OCH2CH3, -(CH2)3-(O(CH2)2)4-OCH2CH3, -(CH2)3-(O(CH2)2)5-OCH2CH3, -(CH2)3-(O(CH2)2)6-OCH2CH3, -(CH2)3-(O(CH2)2)7-OCH2CH3, -(CH2)3-(O(CH2)2)8-OCH2CH3, -(CH2)3-(O(CH2)2)9-OCH2CH3, -(CH2)3-(O(CH2)2)10-OCH2CH3, -(CH2)4-(O(CH2)2)1-OCH2CH3, -(CH2)4-(O(CH2)2)2-OCH2CH3, -(CH2)4-(O(CH2)2)3-OCH2CH3, -(CH2)4-(O(CH2)2)4-OCH2CH3, -(CH2)4-(O(CH2)2)5-OCH2CH3, -(CH2)4-(O(CH2)2)6-OCH2CH3, -(CH2)4-(O(CH2)2)7-OCH2CH3, -(CH2)4-(O(CH2)2)8-OCH2CH3, -(CH2)4-(O(CH2)2)9-OCH2CH3, -(CH2)4-(0(CH2)2)lO-OCH2CH3, -CH2-(O(CH2)3)1-OCH2CH2CH3, -CH2-(O(CH2)3)2-OCH2CH2CH3, -CH2-(O(CH2)3)3-OCH2CH2CH3, -CH2-(O(CH2)3)4-OCH2CH2CH3, -CH2-(O(CH2)3)5-OCH2CH2CH3, -CH2-(O(CH2)3)6-OCH2CH2CH3, -CH2-(O(CH2)3)7-OCH2CH2CH3, -CH2-(O(CH2)3)8-OCH2CH2CH3, -CH2-(O(CH2)3)9-OCH2CH2CH3, -CH2-(O(CH2)3)10-OCH2CH2CH3, -(CH2)2-(O(CH2)3)1-OCH2CH2CH3, -(CH2)2-(O(CH2)3)2-OCH2CH2CH3, -(CH2)2-(O(CH2)3)3-OCH2CH2CH3, - (CH2)2-(O(CH2)3)4-OCH2CH2CH3, -(CH2)2-(O(CH2)3)5-OCH2CH2CH3, -(CH2)2-(O(CH2)3)6-OCH2CH2CH3, -(CH2)2-(O(CH2)3)7-OCH2CH2CH3, -(CH2)2-(O(CH2)3)8-OCH2CH2CH3, -(CH2)3-(O(CH2)3)1-OCH2CH2CH3, -(CH2)3-(O(CH2)3)2-OCH2CH2CH3, -(CH2)3-(O(CH2)3)3-OCH2CH2CH3, - (CH2)3-(O(CH2)3)4-OCH2CH2CH3, -(CH2)3-(O(CH2)3)5-OCH2CH2CH3, -(CH2)3-(O(CH2)3)6-OCH2CH2CH3, -(CH2)3-(O(CH2)3)7-OCH2CH2CH3, -(CH2)3-(O(CH2)3)8-OCH2CH2CH3, -CH2-O-(CH2)2-O-(CH2)2-CH3, -CH2-(O(CH2)2)2-(O(CH2)3)1-OCH2CH2CH3, -CH2-(O(CH2)2)3-(O(CH2)3)2-OCH2CH2CH3, -CH2-(O(CH2)2)4-(O(CH2)3)3-OCH2CH2CH3, -CH2-(O(CH2)2)5-(O(CH2)3)4-OCH2CH2CH3, -(CH2)2-O-(CH2)2-O-(CH2)2CH3, -(CH2)2-(O(CH2)2)2-(O(CH2)3)1-OCH2CH2CH3, - (CH2)2-(O(CH2)2)3-(O(CH2)3)2-OCH2CH2CH3, -(CH2)2-(O(CH2)2)4-(O(CH2)3)3-OCH2CH2CH3, - (CH2)2-(O(CH2)2)5-(O(CH2)3)4-OCH2CH2CH3, -(CH2)3-O-(CH2)2-O-(CH2)2CH3, -(CH2)3-(O(CH2)2)2-(O(CH2)3)1-OCH2CH2CH3, -(CH2)3-(O(CH2)2)3-(O(CH2)3)2-OCH2CH2CH3, -(CH2)3-(O(CH2)2)4-(O(CH2)3)3-OCH2CH2CH3, -(CH2)3-(O(CH2)2)5-(O(CH2)3)4-OCH2CH2CH3, -CH2-O-(CH2)3-O-CH2CH3, -CH2-(O(CH2)3)2-(O(CH2)2)1-O-CH2CH3, -CH2-(O(CH2)3)3-(O(CH2)2)2-O-CH2CH3, -CH2-(O(CH2)3)4-(O(CH2)2)3-O-CH2CH3, -CH2-(O(CH2)3)5-(O(CH2)2)4-O-CH2CH3, -(CH2)2-O-(CH2)3-O-CH2CH3, -(CH2)2-(O(CH2)3)2-(O(CH2)2)1-O-CH2CH3, -(CH2)2-(O(CH2)3)3-(O(CH2)2)2-O-CH2CH3, - (CH2)2-(O(CH2)3)4-(O(CH2)2)3-O-CH2CH3, -(CH2)2-(O(CH2)3)5-(O(CH2)2)4-O-CH2CH3, -(CH2)3-O-(CH2)3-O-CH2CH3, -(CH2)3-(O(CH2)3)2-(O(CH2)2)1-O-CH2CH3, -(CH2)3-(O(CH2)3)3-(O(CH2)2)2-O-CH2CH3, -(CH2)3-(O(CH2)3)4-(O(CH2)2)3-O-CH2CH3, -(CH2)3-(O(CH2)3)5-(O(CH2)2)4-O-CH2CH3, - CH2-O-(CH2)2-O-CH3, -(CH2)2-O-(CH2)2-O-CH3, -(CH2)2-(O(CH2)2)2-O-(CH2)2CH3, -(CH2)2-(O(CH2)2)3-O-(CH2)2CH3, -(CH2)2-(O(CH2)2)4-O-(CH2)2CH3, -(CH2)5-(O(CH2)2)2-O-(CH2)4CH3, - (CH2)5-(O(CH2)2)2-O-(CH2)5CH3, -(CH2)1-N(Re)-CH3, -(CH2)1-N(Re)-(CH2)1-CH3, -(CH2)1-N(Re)-(CH2)2-CH3, -(CH2)1-N(Re)-(CH2)3-CH3, -(CH2)1-N(Re)-(CH2)4-CH3, -(CH2)1-N(Re)-(CH2)5-CH3, - (CH2)1-N(Re)-(CH2)6-CH3, -(CH2)1-N(Re)-(CH2)7-CH3, -(CH2)1-N(Re)-(CH2)8-CH3, -(CH2)1-N(Re)-(CH2)9-CH3, -(CH2)2-N(Re)-CH3, -(CH2)2-N(Re)-(CH2)1-CH3, -(CH2)2-N(Re)-(CH2)2-CH3, -(CH2)2-N(Re)-(CH2)3-CH3, -(CH2)2-N(Re)-(CH2)4-CH3, -(CH2)2-N(Re)-(CH2)5-CH3, -(CH2)2-N(Re)-(CH2)6-CH3, -(CH2)2-N(Re)-(CH2)7-CH3, -(CH2)2-N(Re)-(CH2)8-CH3, -(CH2)2-N(Re)-(CH2)9-CH3, -(CH2)2-N(Re)-(CH2)10-CH3, -(CH2)2-N(Re)-(CH2)11-CH3, -(CH2)3-N(Re)-CH3, -(CH2)3-N(Re)-(CH2)1-CH3, - (CH2)3-N(Re)-(CH2)2-CH3, -(CH2)4-N(Re)-CH3, -(CH2)4-N(Re)-(CH2)1-CH3, -(CH2)4-N(Re)-(CH2)2-CH3, -(CH2)4-N(Re)-(CH2)3-CH3, -(CH2)5-N(Re)-CH3, -(CH2)5-N(Re)-(CH2)1-CH3, -(CH2)5-N(Re)-(CH2)2-CH3, -(CH2)5-N(Re)-(CH2)3-CH3, -(CH2)5-N(Re)-(CH2)4-CH3, -(CH2)6-N(Re)-CH3, -(CH2)6-N(Re)-(CH2)1-CH3, -(CH2)6-N(Re)-(CH2)2-CH3, -(CH2)7-N(Re)-CH3, -(CH2)7-N(Re)-(CH2)1-CH3, - (CH2)7-N(Re)-(CH2)2-CH3, -(CH2)8-N(Re)-CH3, -(CH2)8-N(Re)-(CH2)1-CH3, -(CH2)8-N(Re)-(CH2)2-CH3, -CH(CH3)-N(Re)-CH3, -CH(CH3)-N(Re)-(CH2)1-CH3, -CH(CH3)-N(Re)-(CH2)2-CH3, -CH(CH3)-N(Re)-(CH2)3-CH3, -CH(CH3)-N(Re)-(CH2)4-CH3, -CH(CH3)-N(Re)-(CH2)5-CH3, -CH(CH3)-N(Re)-(CH2)6-CH3, -CH(CH3)-N(Re)-(CH2)7-CH3, -CH(CH3)-N(Re)-(CH2)8-CH3, -CH(CH3)-N(Re)-(CH2)9-CH3, -CH2C(O)NHCH3, -(CH2)2C(O)NHCH2CH3, -(CH2)2C(O)NH(CH2)2-CH3, - (CH2)2C(O)NH(CH2)3-CH3, -(CH2)2C(O)NH(CH2)4-CH3, -(CH2)3C(O)NH(CH2)2-CH3, - (CH2)3C(O)NH(CH2)3-CH3, -(CH2)4C(O)NH(CH2)3-CH3, -(CH2)5C(O)NH(CH2)4-CH3, - (CH2)6C(O)NH(CH2)6-CH3, -(CH2)6C(O)NH(CH2)5-CH3, -(CH2)7C(O)NH(CH2)6-CH3, - (CH2)8C(O)NH(CH2)7-CH3, U-(CH2)9C(O)NH(CH2)8-CH3, -(CH2)10C(O)NH(CH2)9-CH3, - (CH2)2C(O)NH(CH2)2-O-CH2-CH3, -CH2NHC(O)CH3, -(CH2)2NHC(O)CH2CH3, - (CH2)2NHC(O)(CH2)2-CH3, -(CH2)2NHC(O)(CH2)3-CH3, -(CH2)2NHC(O)(CH2)4-CH3, - (CH2)3NHC(O)(CH2)2-CH3, -(CH2)3NHC(O)(CH2)3-CH3, -(CH2)4NHC(O)(CH2)3-CH3, - (CH2)5NHC(O)(CH2)4-CH3, -(CH2)6NHC(O)(CH2)6-CH3, -(CH2)6NHC(O)(CH2)5-CH3, - (CH2)7NHC(O)(CH2)6-CH3, -(CH2)8NHC(O)(CH2)7-CH3, -(CH2)9NHC(O)(CH2)8-CH3, - (CH2)10NHC(O)(CH2)9-CH3, -(CH2)4NHC(O)(CH2)7-CH3, -(CH2)2NHC(O)(CH2)2-O-CH2-CH3, - (CH2)4NHC(O)CH3, -CH2-piperidinylene-CH3, -CH2-piperidinylene-CH2-CH3, -CH2-piperidinylene-(CH2)2-CH3, -CH2-piperidinylene-(CH2)3-CH3, -CH2-piperidinylene-(CH2)4-CH3, -CH2-piperidinylene-(CH2)5-CH3, -CH2-piperidinylene-(CH2)6-CH3, -CH2-piperidinylene-(CH2)7-CH3, - (CH2)2-piperidinylene-CH3, -(CH2)2-piperidinylene-CH2-CH3, -(CH2)2-piperidinylene-(CH2)2-CH3, - (CH2)2-piperidinylene-(CH2)3-CH3, -(CH2)2-piperidinylene-(CH2)4-CH3, -(CH2)2-piperidinylene-(CH2)5-CH3, -(CH2)2-piperidinylene-(CH2)6-CH3, -(CH2)2-piperidinylene-(CH2)7-CH3, -(CH2)3-piperidinylene-CH3, -(CH2)3-piperidinylene-CH2-CH3, -(CH2)3-piperidinylene-(CH2)2-CH3, -(CH2)3-piperidinylene-(CH2)3-CH3, -(CH2)3-piperidinylene-(CH2)4-CH3, -(CH2)3-piperidinylene-(CH2)5-CH3, -(CH2)3-piperidinylene-(CH2)6-CH3, -(CH2)3-piperidinylene-(CH2)7-CH3, -(CH2)4-piperidinylene-CH3, -(CH2)4-piperidinylene-CH2-CH3, -(CH2)4-piperidinylene-(CH2)2-CH3, -(CH2)4-piperidinylene-(CH2)3-CH3, -(CH2)4-piperidinylene-(CH2)4-CH3, -(CH2)4-piperidinylene-(CH2)5-CH3, -(CH2)4-piperidinylene-(CH2)6-CH3, -(CH2)4-piperidinylene-(CH2)7-CH3, -(CH2)5-piperidinylene-CH3, - (CH2)5-piperidinylene-CH2-CH3, -(CH2)5-piperidinylene-(CH2)2-CH3, -(CH2)5-piperidinylene-(CH2)3-CH3, -(CH2)5-piperidinylene-(CH2)4-CH3, -(CH2)5-piperidinylene-(CH2)5-CH3, -(CH2)5-piperidinylene-(CH2)6-CH3, -(CH2)5-piperidinylene-(CH2)7-CH3, -(CH2)6-piperidinylene-CH3, - (CH2)6-piperidinylene-CH2-CH3, -(CH2)6-piperidinylene-(CH2)2-CH3, -(CH2)6-piperidinylene-(CH2)3-CH3, -(CH2)6-piperidinylene-(CH2)4-CH3, -(CH2)6-piperidinylene-(CH2)5-CH3, -(CH2)6-piperidinylene-(CH2)6-CH3, -(CH2)6-piperidinylene-(CH2)7-CH3, -(CH2)7-piperidinylene-CH3, - (CH2)7-piperidinylene-CH2-CH3, -(CH2)7-piperidinylene-(CH2)2-CH3, -(CH2)7-piperidinylene-(CH2)3-CH3, -(CH2)7-piperidinylene-(CH2)7-CH3, -(CH2)8-piperidinylene-CH3, -(CH2)8-piperidinylene-CH2-CH3, -(CH2)8-piperidinylene-(CH2)2-CH3, -(CH2)8-piperidinylene-(CH2)3-CH3, -(CH2)8-piperidinylene-(CH2)4-CH3, -(CH2)8-piperidinylene-(CH2)5-CH3, -(CH2)8-piperidinylene-(CH2)6-CH3, -(CH2)8-piperidinylene-(CH2)7-CH3, -CH2-N(Re)-CH2-piperidinylene-CH3, -CH2-N(Re)-CH2-piperidinylene-CH3, -CH2-N(Re)-CH2-piperidinylene-(CH2)2-CH3, -CH2-N(Re)-CH2-piperidinylene-(CH2)3-CH3, -CH2-N(Re)-CH2-piperidinylene-(CH2)4-CH3, -CH2-N(Re)-CH2-piperidinylene-(CH2)5-CH3, -CH2-N(Re)-CH2-piperidinylene-(CH2)6-CH3, -CH2-N(Re)-CH2-piperidinylene-(CH2)7-CH3, - CH2-N(Re)-(CH2)2-piperidinylene-CH3, -CH2-N(Re)-(CH2)2-piperidinylene-CH2-CH3, -CH2-N(Re)-(CH2)2-piperidinylene-(CH2)2-CH3, -CH2-N(Re)-(CH2)2-piperidinylene-(CH2)3-CH3, -CH2-N(Re)-(CH2)2-piperidinylene-(CH2)4-CH3, -CH2-N(Re)-(CH2)2-pipendinylene-(CH2)5-CH3, -CH2-N(Re)-(CH2)2-piperidinylene-(CH2)6-CH3, -CH2-N(Re)-(CH2)2-piperidinylene-(CH2)7-CH3, -(CH2)2-N(Re)-CH2-piperidinylene-CH3, -(CH2)2-N(Re)-CH2-piperidinylene-CH2-CH3, -(CH2)2-N(Re)-CH2-piperidinylene-(CH2)2-CH3, -(CH2)2-N(Re)-CH2-piperidinylene-(CH2)3-CH3, -(CH2)2-N(Re)-CH2-piperidinylene-(CH2)4-CH3, -(CH2)2-N(Re)-CH2-piperidinylene-(CH2)5-CH3, -(CH2)2-N(Re)-CH2-piperidinylene-(CH2)6-CH3, -(CH2)2-N(Re)-CH2-piperidinylene-(CH2)7-CH3, -(CH2)3-N(Re)-CH2-piperidinylene-CH3, -(CH2)3-N(Re)-CH2-piperidinylene-CH2-CH3, -(CH2)3-N(Re)-CH2-piperidinylene-(CH2)2-CH3, -(CH2)3-N(Re)-CH2-piperidinylene-(CH2)7-CH3, -(CH2)4-N(Re)-CH2-piperidinylene-CH3, -(CH2)4-N(Re)-CH2-piperidinylene-CH2-CH3, -(CH2)4-N(Re)-CH2-piperidinylene-(CH2)2-CH3, - (CH2)4-N(Re)-CH2-piperidinylene-(CH2)7-CH3, -(CH2)5-N(Re)-CH2-piperidinylene-(CH2)2-CH3, - (CH2)5-N(Re)-CH2-piperidinylene-(CH2)7-CH3, -(CH2)6-N(Re)-CH2-piperidinylene-(CH2)2-CH3, - (CH2)6-N(Re)-CH2-piperidinylene-(CH2)7-CH3, -(CH2)7-N(Re)-CH2-piperidinylene-(CH2)2-CH3, - (CH2)7-N(Re)-CH2-piperidinylene-(CH2)7-CH3, -(CH2)8-N(Re)-CH2-piperidinylene-CH3, -(CH2)8-N(Re)-CH2-piperidinylene-CH2-CH3, -(CH2)8-N(Re)-CH2-piperidinylene-(CH2)2-CH3, -(CH2)8-N(Re)-CH2-piperidinylene-(CH2)3-CH3, -(CH2)8-N(Re)-CH2-piperidinylene-(CH2)4-CH3, -(CH2)8-N(Re)-CH2-piperidinylene-(CH2)5-CH3, -(CH2)8-N(Re)-CH2-piperidinylene-(CH2)6-CH3, -(CH2)8-N(Re)-CH2-piperidinylene-(CH2)7-CH3, -CH2-piperazinylene-CH3, -CH2-piperazinylene-CH2-CH3, -CH2-piperazinylene-(CH2)2-CH3, -CH2-piperazinylene-(CH2)3-CH3, -CH2-piperazinylene-(CH2)4-CH3, - CH2-piperazinylene-(CH2)5-CH3, -CH2-piperazinylene-(CH2)6-CH3, -CH2-piperazinylene-(CH2)7-CH3, -(CH2)2-piperazinylene-CH3, -(CH2)2-piperazinylene-CH2-CH3, -(CH2)2-piperazinylene-(CH2)2-CH3, - (CH2)2-piperazinylene-(CH2)3-CH3, -(CH2)2-piperazinylene-(CH2)4-CH3, -(CH2)2-piperazinylene-(CH2)5-CH3, -(CH2)2-piperazinylene-(CH2)6-CH3, -(CH2)2-piperazinylene-(CH2)7-CH3, -(CH2)3-piperazinylene-CH3, -(CH2)3-piperazinylene-CH2-CH3, -(CH2)3-piperazinylene-(CH2)2-CH3, -(CH2)3-piperazinylene-(CH2)3-CH3, -(CH2)3-piperazinylene-(CH2)4-CH3, -(CH2)3-piperazinylene-(CH2)5-CH3, -(CH2)3-piperazinylene-(CH2)6-CH3, -(CH2)3-piperazinylene-(CH2)7-CH3, -(CH2)4-piperazinylene-CH3, -(CH2)4-piperazinylene-CH2-CH3, -(CH2)4-piperazinylene-(CH2)2-CH3, -(CH2)4-piperazinylene-(CH2)3-CH3, -(CH2)4-piperazinylene-(CH2)4-CH3, -(CH2)4-piperazinylene-(CH2)5-CH3, -(CH2)4-piperazinylene-(CH2)6-CH3, -(CH2)4-piperazinylene-(CH2)7-CH3, -(CH2)5-piperazinylene-CH3, - (CH2)5-piperazinylene-CH2-CH3, -(CH2)5-piperazinylene-(CH2)2-CH3, -(CH2)5-piperazinylene-(CH2)3-CH3, -(CH2)5-piperazinylene-(CH2)4-CH3, -(CH2)5-piperazinylene-(CH2)5-CH3, -(CH2)5-piperazinylene-(CH2)6-CH3, -(CH2)5-piperazinylene-(CH2)7-CH3, -(CH2)6-piperazinylene-CH3, - (CH2)6-piperazinylene-CH2-CH3, -(CH2)6-piperazinylene-(CH2)2-CH3, -(CH2)6-piperazinylene-(CH2)3-CH3, -(CH2)6-piperazinylene-(CH2)4-CH3, -(CH2)6-piperazinylene-(CH2)5-CH3, -(CH2)6-piperazinylene-(CH2)6-CH3, -(CH2)6-piperazinylene-(CH2)7-CH3, -(CH2)7-piperazinylene-CH3, - (CH2)7-piperazinylene-CH2-CH3, -(CH2)7-piperazinylene-(CH2)2-CH3, -(CH2)7-piperazinylene-(CH2)3-CH3, -(CH2)7-piperazinylene-(CH2)7-CH3, -(CH2)8-piperazinylene-CH3, -(CH2)8-piperazinylene-CH2-CH3, -(CH2)8-piperazinylene-(CH2)2-CH3, -(CH2)8-piperazinylene-(CH2)3-CH3, -(CH2)8-piperazinylene-(CH2)4-CH3, -(CH2)8-piperazinylene-(CH2)5-CH3, -(CH2)8-piperazinylene-(CH2)6-CH3, or -(CH2)8-piperazinylene-(CH2)7-CH3; wherein the piperidinylene and piperazinylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, nitro, halogen, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, halogenated C1-6 alkyl, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, cyano, or any combination thereof; a hydrogen atom of CH3 of the groups and a hydrogen atom of one or more CH2 of the groups are optionally substituted with a substituent selected from the group consisting of deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C1-6 alkyl, halogenated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, or any combination thereof; each Re independently represents H or C1-6 alkyl; and n1, n2, n3, n4, m4, m5, and m6 each independently represent an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

11. The compound of Formula (I) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 9, which is selected from: 3-(5-(bromomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(chloromethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(iodomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(hydroxymethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(6-fluoro-5-(hydroxymethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-fluoro-5-(hydroxymethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(7-fluoro-5-(hydroxymethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(aminomethyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(aminomethyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(aminomethyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; (2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl 4-methylbenzenesulfonate; (2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl methanesulfonate; (2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl trifluoromethanesulfonate; 3-(5-(bromomethyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(bromomethyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(bromomethyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(7-bromo-5-(bromomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(6-bromo-5-(bromomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-bromo-5-(bromomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((3,6-diazabicyclo[3.1.1]heptan-3-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((3,6-diazabicyclo[3.1.1]heptan-6-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((3,8-diazabicyclo[3.2.1]octan-8-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((3,8-diazabicyclo[3.2.1]octan-3-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((2,S-diazabicyclo[2.2.1]heptan-2-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((2,5-diazabicyclo[2.2.2]octan-2-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(1-oxo-5-((piperazin-1-yl-2,2,3,3,5,5,6,6-d8)methyl)isoindolin-2-yl)piperidine-2,6-dione; 3-(5-((2,6-dimethylpiperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((3,5-dimethylpiperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(7-fluoro-1-oxo-5-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione; 3-(7-chloro-1-oxo-5-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione; 3-(7-bromo-1-oxo-5-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione; 3-(4-fluoro-1-oxo-5-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione; 3-(4-chloro-1-oxo-5-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione; 3-(4-bromo-1-oxo-5-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione; 3-(6-fluoro-1-oxo-5-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione; 3-(6-chloro-1-oxo-5-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione; 3-(6-bromo-1-oxo-5-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione; 3-(4-(bromomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-(chloromethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-(iodomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-(hydroxymethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-fluoro-4-(hydroxymethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(6-fluoro-4-(hydroxymethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(7-fluoro-4-(hydroxymethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-(aminomethyl)-5-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-(aminomethyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-(aminomethyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; (2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)methyl 4-methylbenzenesulfonate; (2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)methyl methanesulfonate; (2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)methyl trifluoromethanesulfonate; 3-(4-(bromomethyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-(bromomethyl)-5-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-(bromomethyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(7-bromo-4-(bromomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(6-bromo-4-(bromomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-bromo-4-(bromomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-((3,6-diazabicyclo[3.1.1]heptan-3-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-((3,6-diazabicyclo[3.1.1]heptan-6-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-((3,8-diazabicyclo[3.2.1]octan-8-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-((3,8-diazabicyclo[3.2.1]octan-3-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-((2,5-diazabicyclo[2.2.1]heptan-2-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-((2,5-diazabicyclo[2.2.2]octan-2-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(1-oxo-4-((piperazin-1-yl-2,2,3,3,5,5,6,6- d8)methyl)isoindolin-2-yl)piperidine-2,6-dione; 3-(4-((2,6-dimethylpiperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-((3,5-dimethylpiperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(7-fluoro-1-oxo-4-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione; 3-(7-chloro-1-oxo-4-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione; 3-(7-bromo-1-oxo-4-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione; 3-(5-fluoro-1-oxo-4-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione; 3-(5-chloro-1-oxo-4-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione; 3-(5-bromo-1-oxo-4-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione; 3-(6-fluoro-1-oxo-4-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione; 3-(6-chloro-1-oxo-4-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione; 3-(6-bromo-1-oxo-4-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione; 3-(6-(bromomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(7-(bromomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((R)-3-aminopiperidin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((S)-3-aminopiperidin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-aminopiperidin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(1-oxo-5-(piperidin-4-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione; 3-(5-(azetidin-3-ylmethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-(((R)-3-aminopiperidin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-(((S)-3-aminopiperidin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-((4-aminopiperidin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione3-(1-oxo-4-(piperazin-1-ylmethyl)isoindolin-2-yl)piperidine-2,6-dione; 3-(4-(azetidin-3-ylmethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 5-(chloromethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 2-(2,6-dioxopiperidin-3-yl)-5-(iodomethyl)isoindoline-1,3-dione; 2-(2,6-dioxopiperidin-3-yl)-5-(hydroxymethyl)isoindoline-1,3-dione; 2-(2,6-dioxopiperidin-3-yl)-4-fluoro-5-(hydroxymethyl)isoindoline-1,3-dione; 2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(hydroxymethyl)isoindoline-1,3-dione; 2-(2,6-dioxopiperidin-3-yl)-4-fluoro-6-(hydroxymethyl)isoindoline-1,3-dione; 5-(aminomethyl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione; 5-(aminomethyl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione; 6-(aminomethyl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione; (2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)methyl 4-methylbenzenesulfonate; (2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)methyl methanesulfonate; (2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)methyl trifluoromethanesulfonate; 6-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione; 5-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione; 5-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione; 4- bromo-6-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 5-bromo-6-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 4-bromo-5-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 5-((3,6-diazabicyclo[3.1.1]heptan-3-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 5-((3,6-diazabicyclo[3.1.1]heptan-6-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 5-((3,8-diazabicyclo[3.2.1]octan-8-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 5-((3,8-diazabicyclo[3.2.1]octan-3-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 5-((2,5-diazabicyclo[2.2.1]heptan-2-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 5-((2,5-diazabicyclo[2.2.2]octan-2-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 2-(2,6-dioxopiperidin-3-yl)-5-((piperazin-1-yl-2,2,3,3,5,5,6,6- d8)methyl)isoindoline-1,3-dione; 5-((2,6-dimethylpiperazin-1-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 5-((3,5-dimethylpiperazin-1-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 2-(2,6-dioxopiperidin-3-yl)-4-fluoro-6-(piperazin-1-ylmethyl)isoindoline-1,3-dione; 4-chloro-2-(2,6-dioxopiperidin-3-yl)-6-(piperazin-1-ylmethyl)isoindoline-1,3-dione; 4-bromo-2-(2,6-dioxopiperidin-3-yl)-6-(piperazin-1-ylmethyl)isoindoline-1,3-dione; 2-(2,6-dioxopiperidin-3-yl)-4-fluoro-5-(piperazin-1-ylmethyl)isoindoline-1,3-dione; 4-chloro-2-(2,6-dioxopiperidin-3-yl)-5-(piperazin-1-ylmethyl)isoindoline-1,3-dione; 4-bromo-2-(2,6-dioxopiperidin-3-yl)-5-(piperazin-1-ylmethyl)isoindoline-1,3-dione; 2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(piperazin-1-ylmethyl)isoindoline-1,3-dione; 5-chloro-2-(2,6-dioxopiperidin-3-yl)-6-(piperazin-1-ylmethyl)isoindoline-1,3-dione; 5-bromo-2-(2,6-dioxopiperidin-3-yl)-6-(piperazin-1-ylmethyl)isoindoline-1,3-dione; 4-(chloromethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 2-(2,6-dioxopiperidin-3-yl)-4-(iodomethyl)isoindoline-1,3-dione; 2-(2,6-dioxopiperidin-3-yl)-4-(hydroxymethyl)isoindoline-1,3-dione; 2-(2,6-dioxopiperidin-3-yl)-5-fluoro-4-(hydroxymethyl)isoindoline-1,3-dione; 2-(2,6-dioxopiperidin-3-yl)-6-fluoro-4-(hydroxymethyl)isoindoline-1,3-dione; 2-(2,6-dioxopiperidin-3-yl)-4-fluoro-7-(hydroxymethyl)isoindoline-1,3-dione; 4-(aminomethyl)-2-(2,6-dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione; 4-(aminomethyl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione; 4-(aminomethyl)-2-(2,6-dioxopiperidin-3-yl)-7-fluoroisoindoline-1,3-dione; (2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)methyl 4-methylbenzenesulfonate; (2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)methyl methanesulfonate; (2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)methyl trifluoromethanesulfonate; 4-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)-7-fluoroisoindoline-1,3-dione; 4-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione; 4-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione; 4-bromo-7-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 6-bromo-4-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 5-bromo-4-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 4-((3,6-diazabicyclo[3.1.1]heptan-3-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 4-((3,6-diazabicyclo[3.1.1]heptan-6-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 4-((3,8-diazabicyclo[3.2.1]octan-8-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 4-((3,8-diazabicyclo[3.2.1]octan-3-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 4-((2,5-diazabicyclo[2.2.1]heptan-2-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 4-((2,5 -di azabicyclo [2.2.2]octan-2-yl)methyl)-2-(2,6-dioxopiperi din-3 -yl)isoindoline-1,3 -dione; 2-(2,6-dioxopiperidin-3-yl)-4-((piperazin-1-yl-2,2,3,3,5,5,6,6- d8)methyl)isoindoline-1,3-dione; 4-((2,6-dimethylpiperazin-1-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 4-((3,5-dimethylpiperazin-1-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 2-(2,6-dioxopiperidin-3-yl)-4-fluoro-7-(piperazin-1-ylmethyl)isoindoline-1,3-dione; 4-chloro-2-(2,6-dioxopiperidin-3-yl)-7-(piperazin-1-ylmethyl)isoindoline-1,3-dione; 4-bromo-2-(2,6-dioxopiperidin-3-yl)-7-(piperazin-1-ylmethyl)isoindoline-1,3-dione; 2-(2,6-dioxopiperidin-3-yl)-5-fluoro-4-(piperazin-1-ylmethyl)isoindoline-1,3-dione; 5-chloro-2-(2,6-dioxopiperidin-3-yl)-4-(piperazin-1-ylmethyl)isoindoline-1,3-dione; 5-bromo-2-(2,6-dioxopiperidin-3-yl)-4-(piperazin-1-ylmethyl)isoindoline-1,3-dione; 2-(2,6-dioxopiperidin-3-yl)-6-fluoro-4-(piperazin-1-ylmethyl)isoindoline-1,3-dione; 6-chloro-2-(2,6-dioxopiperidin-3-yl)-4-(piperazin-1-ylmethyl)isoindoline-1,3-dione; 6-bromo-2-(2,6-dioxopiperidin-3-yl)-4-(piperazin-1-ylmethyl)isoindoline-1,3-dione; 5-(((R)-3-aminopiperidin-1-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 5-(((S)-3-aminopiperidin-1-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 5-((4-aminopiperidin-1-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 2-(2,6-dioxopiperidin-3-yl)-5-(piperazin-1-ylmethyl)isoindoline-1,3-dione; 2-(2,6-dioxopiperidin-3-yl)-5-(piperidin-4-ylmethyl)isoindoline-1,3-dione; 5-(azetidin-3-ylmethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 4-(((R)-3-aminopiperidin-1-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 4-(((S)-3-aminopiperidin-1-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 4-((4-aminopiperidin-1-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 4-(azetidin-3-ylmethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; (E)-4-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)but-2-enoic acid; (E)-4-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)methyl)piperazin-1-yl)but-2-enoic acid; (E)-4-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)methyl)piperazin-1-yl)but-2-enoic acid; (E)-4-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)methyl)piperazin-1-yl)but-2-enoic acid; 3-(5-((4-(3-hydroxypropyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-((4-(3-hydroxypropyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 2-(2,6-dioxopiperidin-3-yl)-5-((4-(3-hydroxypropyl)piperazin-1-yl)methyl)isoindoline-1,3-dione; 2-(2,6-dioxopiperidin-3-yl)-4-((4-(3-hydroxypropyl)piperazin-1-yl)methyl)isoindoline-1,3-dione; 3-(5-((4-(3-bromopropyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-((4-(3-bromopropyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 5-((4-(3-bromopropyl)piperazin-1-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 4-((4-(3-bromopropyl)piperazin-1-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 3-(5-((4-hydroxypiperidin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-((4-hydroxypiperidin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 2-(2,6-dioxopiperidin-3-yl)-5-((4-hydroxypiperidin-1-yl)methyl)isoindoline-1,3-dione; 2-(2,6-dioxopiperidin-3-yl)-4-((4-hydroxypiperidin-1-yl)methyl)isoindoline-1,3-dione; 3-(5-((4-bromopiperidin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-((4-bromopiperidin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 5-((4-bromopiperidin-1-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 4-((4-bromopiperidin-1-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 3-(5-(((2-bromoethyl)(methyl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-(((2-bromoethyl)(methyl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 5-(((2-bromoethyl)(methyl)amino)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 4-(((2-bromoethyl)(methyl)amino)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 3-(5-((methyl(piperidin-4-yl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-((methyl(piperidin-4-yl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 2-(2,6-dioxopiperidin-3-yl)-5-((methyl(piperidin-4-yl)amino)methyl)isoindoline-1,3-dione; 2-(2,6-dioxopiperidin-3-yl)-4-((methyl(piperidin-4-yl)amino)methyl)isoindoline-1,3-dione; 3-(1-oxo-5-((4-(piperazin-1-yl)piperidin-1-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione; 3-(1-oxo-4-((4-(piperazin-1-yl)piperidin-1-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione; 2-(2,6-dioxopiperidin-3-yl)-5-((4-(piperazin-1-yl)piperidin-1-yl)methyl)isoindoline-1,3-dione; 2-(2,6-dioxopiperidin-3-yl)-4-((4-(piperazin-1-yl)piperidin-1-yl)methyl)isoindoline-1,3-dione; 3-(1-oxo-5-((4-(piperidin-4-yl)piperazin-1-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione; 3-(1-oxo-4-((4-(piperidin-4-yl)piperazin-1-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione; 2-(2,6-dioxopiperidin-3-yl)-5-((4-(piperidin-4-yl)piperazin-1-yl)methyl)isoindoline-1,3-dione; 2-(2,6-dioxopiperidin-3-yl)-4-((4-(piperidin-4-yl)piperazin-1-yl)methyl)isoindoline-1,3-dione; 3-(1-oxo-5-((4-phenylpiperazin-1-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione; 3-(1-oxo-4-((4-phenylpiperazin-1-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione; 2-(2,6-dioxopiperidin-3-yl)-5-((4-phenylpiperazin-1-yl)methyl)isoindoline-1,3-dione; 2-(2,6-dioxopiperidin-3-yl)-4-((4-phenylpiperazin-1-yl)methyl)isoindoline-1,3-dione; 3-(5-((4-(4-bromophenyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-((4-(4-bromophenyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 5-((4-(4-bromophenyl)piperazin-1-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 4-((4-(4-bromophenyl)piperazin-1-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 3-(1-oxo-5-((4-(pyridazin-3-yl)piperazin-1-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione; 3-(1-oxo-4-((4-(pyridazin-3-yl)piperazin-1-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione; 2-(2,6-dioxopiperidin-3-yl)-5-((4-(pyridazin-3-yl)piperazin-1-yl)methyl)isoindoline-1,3-dione; 2-(2,6-dioxopiperidin-3-yl)-4-((4-(pyridazin-3-yl)piperazin-1-yl)methyl)isoindoline-1,3-dione; 3-(5-((4-(6-chloropyridazin-3-yl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-((4-(6-chloropyridazin-3-yl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 5-((4-(6-chloropyridazin-3-yl)piperazin-1-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 4-((4-(6-chloropyridazin-3-yl)piperazin-1-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 1-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-3-fluoropiperidin-4-yl methanesulfonate; 1-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)methyl)-3-fluoropiperidin-4-yl methanesulfonate; 1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)methyl)-3-fluoropiperidin-4-yl methanesulfonate; 1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)methyl)-3-fluoropiperidin-4-yl methanesulfonate; 1-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperidin-3-yl trifluoromethanesulfonate; 1-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)methyl)piperidin-3-yl trifluoromethanesulfonate; 1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)methyl)piperidin-3-yl trifluoromethanesulfonate; 1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)methyl)piperidin-3-yl trifluoromethanesulfonate; 3-(5-((4-(6-aminopyridin-3-yl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-((4-(6-aminopyridin-3-yl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 5 -((4-(6-aminopyridin-3 -yl)pip erazin-1-yl)methyl)-2-(2, 6-dioxopip eridin-3 -yl)i soindoline-1, 3 - dione; 4-((4-(6-aminopyridin-3 -yl)pip erazin-1-yl)methyl)-2-(2, 6-dioxopip eridin-3 -yl)i soindoline-1, 3 - dione; 3-(5-((4-(azetidin-3-yl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-((4-(azetidin-3-yl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 5-((4-(azetidin-3-yl)piperazin-1-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 4-((4-(azetidin-3-yl)piperazin-1-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 3-(1-oxo-5-((3-(piperazin-1-yl)azetidin-1-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione; 3-(1-oxo-4-((3-(piperazin-1-yl)azetidin-1-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione; 2-(2,6-dioxopiperidin-3-yl)-5-((3-(piperazin-1-yl)azetidin-1-yl)methyl)isoindoline-1,3-dione; 2-(2,6-dioxopiperidin-3-yl)-4-((3-(piperazin-1-yl)azetidin-1-yl)methyl)isoindoline-1,3-dione; 3-(5-((4-methylpiperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-((4-methylpiperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 2-(2,6-dioxopiperidin-3-yl)-5-((4-methylpiperazin-1-yl)methyl)isoindoline-1,3-dione; 2-(2,6-dioxopiperidin-3-yl)-4-((4-methylpiperazin-1-yl)methyl)isoindoline-1,3-dione; 3-(5-((4-(difluoromethyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3 -(4-((4-(difluoromethyl)pip erazin-1-yl)methyl)-1-oxoisoindolin-2-yl)pip eri dine-2, 6-dione; 5-((4-(difluoromethyl)piperazin-1-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 4-((4-(difluoromethyl)piperazin-1-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 3-(1-oxo-5-((piperidin-4-ylamino)methyl)isoindolin-2-yl)piperidine-2,6-dione; 3-(1-oxo-4-((piperidin-4-ylamino)methyl)isoindolin-2-yl)piperidine-2,6-dione; 2-(2,6-dioxopiperidin-3-yl)-5-((piperidin-4-ylamino)methyl)isoindoline-1,3-dione; 2-(2,6-dioxopiperidin-3-yl)-4-((piperidin-4-ylamino)methyl)isoindoline-1,3-dione; 3-(5-((4-(2-aminoethyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-((4-(2-aminoethyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 5-((4-(2-aminoethyl)piperazin-1-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 4-((4-(2-aminoethyl)piperazin-1-yl)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 3-(1-oxo-5-((4-propylpiperazin-1-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione; 3-(1-oxo-4-((4-propylpiperazin-1-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione; 2-(2,6-dioxopiperidin-3-yl)-5-((4-propylpiperazin-1-yl)methyl)isoindoline-1,3-dione; 2-(2,6-dioxopiperidin-3-yl)-4-((4-propylpiperazin-1-yl)methyl)isoindoline-1,3-dione; 3-(5-(((2-hydroxyethyl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-(((2-hydroxyethyl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 2-(2,6-dioxopiperidin-3-yl)-5-(((2-hydroxyethyl)amino)methyl)isoindoline-1,3-dione; 2-(2,6-dioxopiperidin-3-yl)-4-(((2-hydroxyethyl)amino)methyl)isoindoline-1,3-dione; 1-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperidine-4-carboxylic acid; 1-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)methyl)piperidine-4-carboxylic acid; 1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)methyl)piperidine-4-carboxylic acid; 1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)methyl)piperidine-4-carboxylic acid; 1'-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-[1,4'-bipiperidine]-4-carboxylic acid; 1'-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)methyl)-[1,4'-bipiperidine]-4-carboxylic acid; 1'-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)methyl)-[1,4'-bipiperidine]-4-carboxylic acid; 1'-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)methyl)-[1,4'-bipiperidine]-4-carboxylic acid; 3-(5-((4-ethynylpiperidin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3 -(4-((4-ethynylpip eridin-1-yl)methyl)-1-oxoisoindolin-2-yl)pip eri dine-2, 6-dione; 2-(2,6-dioxopiperidin-3-yl)-5-((4-ethynylpiperidin-1-yl)methyl)isoindoline-1,3-dione; 2-(2,6-dioxopiperidin-3-yl)-4-((4-ethynylpiperidin-1-yl)methyl)isoindoline-1,3-dione; 3 -(1 -oxo-5 -((3 -(piperazin-1 -yl)piperidin-1 -yl)methyl)isoindolin-2-yl)piperidine-2,6-dione; 3 -(1 -oxo-4-((3 -(piperazin-1-yl)piperidin-1-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione; 2-(2,6-dioxopiperidin-3-yl)-5-((3-(piperazin-1-yl)piperidin-1-yl)methyl)isoindoline-1,3-dione; 2-(2,6-dioxopiperidin-3-yl)-4-((3-(piperazin-1-yl)piperidin-1-yl)methyl)isoindoline-1,3-dione; 3-(5-(((4-methylpiperidin-4-yl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-(((4-methylpiperidin-4-yl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 2-(2,6-dioxopiperidin-3-yl)-5-(((4-methylpiperidin-4-yl)amino)methyl)isoindoline-1,3-dione; 2-(2,6-dioxopiperidin-3-yl)-4-(((4-methylpiperidin-4-yl)amino)methyl)isoindoline-1,3-dione; 3-(5-(((3-methyl-2-oxa-8-azaspiro[4.5]decan-4-yl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-(((3-methyl-2-oxa-8-azaspiro[4.5]decan-4-yl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 2-(2,6-dioxopiperidin-3-yl)-5-(((3-methyl-2-oxa-8-azaspiro[4.5]decan-4-yl)amino)methyl)isoindoline-1,3-dione; 2-(2,6-dioxopiperidin-3-yl)-4-(((3-methyl-2-oxa-8-azaspiro[4.5]decan-4-yl)amino)methyl)isoindoline-1,3-dione; 2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindoline-5-carbaldehyde; 2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindoline-5-carbaldehyde; 2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindoline-5-carbaldehyde; 2-(2,6-dioxopiperidin-3-yl)-5-fluoro-1-oxoisoindoline-4-carbaldehyde; 2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindoline-4-carbaldehyde; 2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindoline-4-carbaldehyde; 2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1,3-dioxoisoindoline-5-carbaldehyde; 2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindoline-5-carbaldehyde; 2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1,3-dioxoisoindoline-5-carbaldehyde; 2-(2,6-dioxopiperidin-3-yl)-5-fluoro-1,3-dioxoisoindoline-4-carbaldehyde; 2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindoline-4-carbaldehyde; 2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1,3-dioxoisoindoline-4-carbaldehyde; 3-(4-bromo-6-(bromomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-bromo-6-(bromomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(7-bromo-6-(bromomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(6-(bromomethyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(6-(bromomethyl)-5-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(6-(bromomethyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(7-(bromomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-bromo-7-(bromomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-bromo-7-(bromomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(6-bromo-7-(bromomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(7-(bromomethyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(7-(bromomethyl)-5-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(7-(bromomethyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 4-bromo-6-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 5-bromo-6-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 4-bromo-5-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 6-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione; 5-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione; 5-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione; 4-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 4-bromo-7-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 6-bromo-4-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 5-bromo-4-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 4-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)-7-fluoroisoindoline-1,3-dione; 4-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione; and 4-(bromomethyl)-2-(2,6-dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione.

12. A compound of Formula (II)         PBM-Rf-LIN-ULM     Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof, wherein PBM-Rf- represents a targeting moiety capable of binding protein, ULM represents a E3 ubiquitin ligase ligand moiety, LIN is a linker moiety, and PBM-Rf- is covalently bonded to ULM through LIN; ULM represents the structure of Formula (ULM): wherein A represents CO, CH2 or CD2; R1, R2, R3 and R4 are the same or different and each independently represent hydrogen, deuterium, halogen, optionally deuterated C1-6 alkyl, optionally deuterated C1-6 alkoxy, or halogenated C1-6 alkyl; (Rb)n indicates that the benzene ring is optionally substituted with n Rb substituents, with each Rb being the same or different and independently representing deuterium, halogen, hydroxy, mercapto, nitro, amino, cyano, optionally deuterated C1-6 alkyl, optionally deuterated C1-6 alkoxy, halogenated C1-6 alkyl, optionally substituted C3-6 cycloalkyl, C2-6 alkenyl or C2-6 alkynyl; n represents an integer of 0, 1, 2 or 3; LIN represents the structure of the following formula: wherein R5 and R6 are the same or different and each independently represent hydrogen, fluorine, chlorine, bromine, iodine, optionally substituted methyl, or optionally substituted linear or branched C2-30 alkyl, wherein one or more groups Re and / or one or more groups Rd and / or any combination of one or more groups Rc and Rd are optionally inserted into the backbone carbon chain of the linear or branched C2-30 alkyl group, wherein carbon-carbon bond between one or more pairs of adj acent carbon atoms in the backbone carbon chain is interrupted by the group Rc, Rd, or a combination of Rc and Rd; wherein each Rc is selected from the group consisting of O, N(Re), C(O), C(O)O, S(O), S(O)2, S(O)2NH, NHS(O)2, OC(O), C(O)N(Re), N(Re)C(O), or N(Re)C(O)N(Re), where each Re independently represents H or C1-6 alkyl, and in case that two or more groups Re are inserted into the backbone carbon chain of the linear or branched C2-30 alkyl group, the two or more groups Re are not directly connected to each other; and wherein each Rd is selected from the group consisting of cycloalkylene, arylene, heterocyclylene, heteroarylene, alkynylene, alkenylene, or any combination thereof, wherein the cycloalkylene, arylene, heterocyclylene, and heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, cyano, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, halogenated C1-6 alkyl, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, or any combination thereof; Rf represents a bond, -O-, -N(Rg)-, -NHC(O)-Rh-W5-*, -C(O)NH-Rh-W5-*, -NHC(O)-W5-*, - C(O)NH-W5-*, -NHC(O)-*, -C(O)NH-*, -O-Rh-W5-*, -O-W5-*, -O-Rh-N(Ri)-*, -N(Rg)-Rh-N(Ri)-*, - W5-, -W5-N(Rg)-*, -N(Rg)-W5-*, -N(Rg)-W5-N(Ri)-*, -Rh-W5-*, -Rh-C(O)-W5-*, -C(O)-W5-*, -Rh-C(O)NH-Rj-W5-*, -Rh-NHC(O)-Rj-W5-*, -Rh-C(O)NH-*, -Rh-NHC(O)-*, -Rh-, -Rh-N(Ri)-*, or wherein W5 represents the structure of the following formula: wherein each ring W6 is the same or different and each independently represents nitrogen-containing heterocyclylene, t1 represents an integer of 1 or 2, (Ra2)m2 indicates that each ring W6 is optionally substituted with m2 Ra2 substituents, with each Ra2 independently representing deuterium, optionally deuterated C1-6 alkyl, optionally halogenated C1-6 alkyl, C1-6 alkoxy, halogen, amino, hydroxy, mercapto, cyano, carboxyl, C2-6 alkynyl, C2-6 alkenyl, optionally deuterated C3-6 cycloalkyl, or R12a-R11a-, where R11a is optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, and R12a represents halogen, R13aR14aN-, hydroxy, carboxyl, ethynyl, or vinyl, wherein R13a and R14a are the same or different and each independently represent hydrogen or C1-3 alkyl, and m2 represents an integer of 0-20; each ring W7 is the same or different and each independently represents nitrogen-containing heterocyclylene, arylene, or heteroarylene, t2 represents an integer of 0 or 1, (Ra3)m3 indicates that each ring W7 is independently optionally substituted with m3 Ra3 substituents, with each Ra3 independently representing deuterium, optionally deuterated C1-6 alkyl, C1-6 alkoxy, halogen, amino, hydroxy, mercapto, cyano, carboxyl, C2-6 alkynyl, C2-6 alkenyl, optionally deuterated C3-6 cycloalkyl, or R16a-R15a-, where R15a is optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, and R16a represents halogen, R17aR18aN-, hydroxy, carboxyl, ethynyl, or vinyl, wherein R17a and R18a are the same or different and each independently represent hydrogen or C1-3 alkyl, and m3 represents an integer of 0-20; and Rg and Ri each independently represent hydrogen or C1-6 alkyl, Rh and Rj each independently represent optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, and symbol * indicates the point of attachment to LIN; wherein when PBM represents the structure of the following formula: and simultaneously -Rf-LIN- represents where symbol ** indicates the point of attachment to ULM, (Rb)n indicates that benzene ring of Formula (ULM) is substituted with 1, 2, or 3 Rb, with each Rb being the same or different and each independently representing deuterium, halogen, hydroxy, mercapto, nitro, amino, cyano, optionally deuterated C1-6 alkyl, optionally deuterated C1-6 alkoxy, halogenated C1-6 alkyl, optionally substituted C3-6 cycloalkyl, C2-6 alkenyl, or C2-6 alkynyl; with the proviso that the following compounds are excluded: 3-(4-((3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1- yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; N-(5-(3,5-difluorobenzyl)-1H-indazol-3-yl)-4-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperidin-3-yl)piperazin-1-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide; N-(5-(3,5-difluorobenzyl)-1H-indazol-3-yl)-4-(4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)methyl)piperazin-1-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide; N-(5-(3,5-difluorobenzyl)-1H-indazol-3-yl)-4-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-3-oxoisoindolin-5-yl)methyl)piperidin-3-yl)piperazin-1-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide; N-(5-(3,5-difluorobenzyl)-1H-indazol-3-yl)-4-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-1-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide; N-(5-(3,5-difluorobenzyl)-1H-indazol-3-yl)-4-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)methyl)pyrrolidin-3-yl)piperazin-1-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide; N-(5-(3,5-difluorobenzyl)-1H-indazol-3-yl)-4-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)methyl)piperidin-3-yl)piperazin-1-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide; N-(5-(3,5-difluorobenzyl)-1H-indazol-3-yl)-4-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)methyl)azetidin-3-yl)piperazin-1-yl)-2-((tetrahydro-2H-pyran-4-yl)amino)benzamide; 2-(2,6-dioxopiperidin-3-yl)-5-((4-(6-(6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)pyridin-2-yl)piperazin-1-yl)methyl)isoindoline-1,3-dione; and 2-(2,6-dioxopiperidin-3-yl)-5-((3-(4-(6-(6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3 -yl)pyridin-2-yl)piperazin-1-yl)azetidin-1-yl)methyl)isoindoline-1,3 -dione.

13. The compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 12, wherein the PBM-Rf- represents a small molecule ligand targeting epidermal growth factor receptor (EGFR), Cyclin-dependent kinase 4 / 6 (CDK4 / 6), anaplastic lymphoma kinase (ALK), activin receptor-like kinase 2 (ALK2), fibroblast growth factor receptors (FGFRs), proto-oncogene tyrosine-protein kinase receptor RET (RET), Focal adhesion kinase (FAK), breakpoint cluster region (BCR)-Abelson leukemia virus (ABL) (BCR-ABL) tyrosine kinase, Bruton tyrosine kinase (BTK), Androgen receptor (AR), Estrogen receptor (ER), Bromodomain and extra-terminal domain protein (BET), Interleukin-1 receptorassociated kinase 4 (IRAK4), Cyclin-dependent kinase 9 (CDK9), Histone-lysine N-methyltransferase EZH2 (EZH2), neurotrophic receptor tyrosine kinase (NTRK), Src homology 2 domain containing protein tyrosine phosphatase (SHP2), Poly (ADP-ribose) polymerase (PARP), signal transducers and activators of transcription 3 (STAT3), FMS-like tyrosine kinase 3 (FLT3), B cell lymphoma-2 (BCL-2) family proteins, SOS Ras / Rac guanine nucleotide exchange factor 1 (SOS1), or GTPase Kras (KRAS).

14. The compound of Formula (III) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 12, wherein PBM comprises the structure of formula selected from: wherein (R1)p1 indicates that the benzene ring in Formula (PBM-1) is substituted with p1 R1, with each R1 being the same or different and each independently representing halogen, hydroxy, NH2, NO2, cyano, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy; (R2)p2 indicates that the quinazoline ring in Formula (PBM-1) is substituted with p2 R2, with each R2 being the same or different and each independently representing halogen, NO2, cyano, halogenated C1-6 alkyl, C1-10 alkyl, deuterated C1-10 alkyl, C1-10 alkoxy, halogenated C1-10 alkoxy, -O-optionally substituted heterocyclyl, or -NHC(O)R3, wherein R3 is C1-10 alkyl, deuterated C1-10 alkyl, or C2-10 alkenyl, e.g., R2 represents methyl, methoxy, such as p1 represents an integer of 1, 2, 3, 4 or 5; p2 represents an integer of 1, 2, or 3; (R4)p3 indicates that the benzene ring in Formula (PBM-2) is substituted with p3 R4, with each R4 being the same or different and each independently representing halogen, NO2, cyano, halogenated C1-6 alkyl, C1-10 alkyl, deuterated C1-10 alkyl, C1-10 alkoxy, or -NHC(O)R15a, where R15a is C1-10 alkyl, deuterated C1-10 alkyl, or C2-10 alkenyl, e.g., R4 represents methyl, methoxy, NO2, or p3 represents an integer of 1, 2, 3 or 4; (R5)p4 indicates that the 1H-indole ring in Formula (PBM-2) is substituted with p4 R5, with each R5 being the same or different and each independently representing C1-10 alkyl or deuterated C1-10 alkyl, and p4 represents an integer of 0, 1, 2 or 3; R6 represents hydrogen, C1-10 alkyl, or deuterated C1-10 alkyl; (R7)p5 indicates that the benzene ring in Formula (PBM-3) is substituted with p5 R7, with each R7 being the same or different and each independently representing halogen, hydroxy, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, NO2, NH2, or cyano; p5 represents an integer of 0, 1, 2, 3, 4 or 5; R8 represents substituted or unsubstituted C3-15 cycloalkyl, e.g., cyclopentyl; (R9)p6 indicates that the benzene ring in Formula (PBM-4) is substituted with p6 R9, with each R9 being the same or different and each independently representing halogen, hydroxy, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, NO2, NH2, C1-6 alkoxy, halogenated C1-6 alkoxy, or cyano; p6 represents an integer of 2, 3, 4 or 5; R10 represents C6-10 aryl, or heteroaryl containing one or two 5- to 7-membered rings and 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulfur, wherein the C6-10 aryl and heteroaryl are each optionally substituted with one or more Rb1, with each Rb1 being the same or different and independently representing halogen, hydroxy, cyano, amino, nitro, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy; (R11)p7 indicates that the benzene ring and the pyridine ring in Formula (PBM-5) are each optionally substituted with p7 R11, with each p7 being the same or different and each independently representing an integer of 0, 1, 2 or 3, and each R11 in Formula (PBM-5) is the same or different and each independently represents halogen, C1-6 alkyl, halogenated C1-6 alkyl, or deuterated C1-6 alkyl; R12 represents hydrogen, C1-6 alkyl, halogenated C1-6 alkyl, or deuterated C1-6 alkyl; R13 in Formula (PBM-6) represents hydrogen, C1-10 alkyl (e.g., ), deuterated C1-10 alkyl or halogenated C1-10 alkyl; R14 represents wherein (Rb2)p8 indicates that the piperidine ring is optionally substituted with p8 Rb2, with each Rb2 being the same or different and each independently representing deuterium, halogen, hydroxy, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, deuterated C1-6 alkoxy, NO2, NH2, or cyano, and p8 represents an integer of 1, 2, 3, 4 or 5; ring A in Formula (PBM-7) represents C6-10 aryl or 5- to 20-membered monocyclic or bicyclic heteroaryl containing from 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur, and the ring A is optionally substituted with one or more Rb3, with each Rb3 being the same or different and each independently representing deuterium, halogen, hydroxy, cyano, amino, nitro, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, C2-6 alkenyl, or C2-6 alkynyl; ring B in Formula (PBM-7) represents C3-15 cycloalkyl or 3- to 20-membered heterocyclyl containing from 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur, and the ring B is optionally substituted with one or more Rb4, with each Rb4 being the same or different and each independently representing deuterium, halogen, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy; ring C in Formula (PBM-7) represents 5- to 20-membered monocyclic or bicyclic heteroaryl containing from 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur, and the ring C is optionally substituted with one or more Rb5, with each Rb5 being the same or different and each independently representing deuterium, halogen, hydroxy, cyano, amino, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy; R15 in Formula (PBM-8) represents 4- to 20-membered heterocyclyl containing from 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur, and the heterocyclyl is optionally substituted with one or more Rb6, with each Rb6 being the same or different and each independently representing halogen, hydroxy, cyano, amino, nitro, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy; (R16)p9 indicates that the benzene ring in Formula (PBM-8) is substituted with p9 R16, with each R16 being the same or different and each independently representing halogen, C1-6 alkyl, halogenated C1-6 alkyl, or deuterated C1-6 alkyl, and p9 represents an integer of 1, 2, 3 or 4; X1 in Formula (PBM-9) represents N or CRb7, wherein Rb7 is hydrogen or amino, and X2 represents N or CR17, wherein R17 is hydrogen or represents a bond, and X3 represents CH or N; R18 and R19 each independently represent hydrogen or a bond; (R20)p10 indicates that the benzene ring in Formula (PBM-9) is substituted with p10 R20, with each R20 being the same or different and each independently representing -O-aryl, -O-heteroaryl, -C1-3 alkylene-NHC(O)-heteroaryl, -C1-3 alkylene-C(O)NH-heteroaryl or halogen, wherein the aryl and heteroaryl are each independently optionally substituted with one or more Rb8, with each Rb8 being the same or different and each independently representing deuterium, halogen, hydroxy, cyano, amino, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy; p10 represents an integer of 1, 2, 3 or 4; R21 represents a bond, deuterium, hydrogen, halogen, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, or C1-6 alkoxy; R22 represents hydrogen, halogen, cyano, or amino; wherein R17, R18, R19, and R21 are not simultaneously hydrogen, and R17, R18, R19, and R21 do not simultaneously represent a bond, and only one of R17, R18, R19, and R21 represents a bond, wherein when R18 represents a bond, the carbon atom on the ring connected to R18 is directly connected to Rf, X2 represents CH or N, and R19 is hydrogen, and R21 is not a bond; when X2 represents CR17, where R17 represents a bond, the carbon atom on the ring connected to R17 is directly connected to Rf, and R18 and R19 are hydrogen, and R21 is not a bond; when R19 represents a bond, the nitrogen atom on the ring connected to R19 is directly connected to Rf, X2 represents N or CH, and R18 is hydrogen, and R21 is not a bond; and when R21 represents a bond, the carbon atom on the ring connected to R21 is directly connected to Rf, and X2 represents N or CH, and R18 and R19 are hydrogen; (R23)p11 indicates that the cyclopentene ring in Formula (PBM-10) is substituted with p11 R23, with each R23 being the same or different and each independently representing halogen, C1-6 alkyl, halogenated C1-6 alkyl, or deuterated C1-6 alkyl, and p11 represents an integer of 1, 2, 3, or 4; (R24)p12 indicates that the pyridine ring in Formula (PBM-10) is substituted with p12 R24, with each R24 being the same or different and each independently representing halogen, -C1-3 alkylene -OH, C1-6 alkyl, halogenated C1-6 alkyl, or deuterated C1-6 alkyl, and p12 represents an integer of 1, 2, or 3; R25 represents hydrogen, C1-6 alkyl, halogenated C1-6 alkyl, or deuterated C1-6 alkyl; X4 in Formula (PBM-11) represents CR26 or a fragment wherein symbol # indicates the point of attachment to N atom adjacent to X4, symbol ## indicates the point of attachment to X5, and R26 represents deuterium, hydrogen, halogen, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, - C(O)-C1-6 alkyl, -C(O)-deuterated C1-6 alkyl, or -C(O)NRb9Rb10, where Rb9 and Rb10 are the same or different and each independently represent hydrogen, C1-6 alkyl or deuterated C1-6 alkyl; X5 in Formula (PBM-11) represents N or CR27, where R27 represents hydrogen, deuterium, halogen, C1-6 alkyl, deuterated C1-6 alkyl, or halogenated C1-6 alkyl; X6 and X7 each independently represent CH or N; R28 represents a bond or optionally substituted heteroarylene (e.g., halogenated heteroarylene); R29 represents hydrogen, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, or optionally substituted C3-7 cycloalkyl; R30 and R31 are the same or different and each independently represent hydrogen, halogen, C1-6 alkyl, halogenated C1-6 alkyl, or deuterated C1-6 alkyl; R32 in Formula (PBM-12) represents hydrogen, halogen, C1-6 alkyl, halogenated C1-6 alkyl, or deuterated C1-6 alkyl; R33 represents hydrogen, cyano, halogen, C1-6 alkyl, halogenated C1-6 alkyl, or deuterated C1-6 alkyl; (R34)p13 indicates that the benzene ring in Formula (PBM-13) is substituted with p13 R34, with each R34 being the same or different and independently representing halogen, hydroxy, amino, cyano, C1-6 alkyl, halogenated C1-6 alkyl, or deuterated C1-6 alkyl; p13 represents an integer of 1, 2, 3, 4 or 5; R35 represents NRb11Rb12, where Rb11 and Rb12 are the same or different and independently represent hydrogen, C1-6 alkyl, halogenated C1-6 alkyl, or deuterated C1-6 alkyl; (R36)p14 indicates that the benzene ring in Formula (PBM-14) is optionally substituted with p14 R36, with each R36 in Formula (PBM-14) being the same or different and each independently representing halogen, amino, cyano, C1-6 alkyl, halogenated C1-6 alkyl, or deuterated C1-6 alkyl, and p14 represents an integer of 1, 2 or 3; R37 represents hydrogen, C1-6 alkyl, halogenated C1-6 alkyl, or deuterated C1-6 alkyl; X8, X9, X10, X11 and X12 in Formula (PBM-15) are the same or different and each independently represent N or CH; R38 represents a bond or optionally substituted methylene (e.g., halogenated methylene); R39 represents -C(O)NHRb13, -NHC(O)-Rb13, -S(O)2NHRb13, -N(Rb14)S(O)2Rb13, -S(O)2Rb13 or - P(O)(Rb13)2, wherein each Rb13 is the same or different and each independently represents C1-6 alkyl or deuterated C1-6 alkyl, and Rb14 represents hydrogen or C1-6 alkyl; (R40)p15 indicates that the 6-membered ring containing X9 and X10 in Formula (PBM-15) is optionally substituted with p15 R40, with each R40 being the same or different and independently representing halogen, C1-6 alkoxy, C1-6 alkyl, deuterated C1-6 alkyl or halogenated C1-6 alkyl; p15 represents an integer of 0, 1, 2, 3 or 4; R41 represents halogen, C1-6 alkoxy, C1-6 alkyl, deuterated C1-6 alkyl or halogenated C1-6 alkyl; (R42)p16 indicates that the benzene ring in Formula (PBM-16) is optionally substituted with p16 R42, with each R42 being the same or different and independently representing halogen, C1-6 alkoxy, C1-6 alkyl, deuterated C1-6 alkyl or halogenated C1-6 alkyl; each p16 is the same or different and each independently represents an integer of 0, 1, 2, 3 or 4; (R43)p17 indicates that the benzene ring in Formula (PBM-17) is substituted with p17 R43, with each R43 being the same or different and each independently representing halogen, C1-6 alkoxy, C1-6 alkyl, deuterated C1-6 alkyl or halogenated C1-6 alkyl, and p17 represents an integer of 0, 1, 2, 3 or 4; (R44)p18 indicates that the benzene ring in Formula (PBM-18) is optionally substituted with p18 R44, with each R44 being the same or different and each independently representing halogen, C1-6 alkoxy, C1-6 alkyl, deuterated C1-6 alkyl or halogenated C1-6 alkyl; p18 represents an integer of 0, 1, 2, 3 or 4; (R45)p19 indicates that the 4-oxo-3,4-dihydroquinazoline ring in Formula (PBM-18) is substituted with p19 R45, with each R45 being the same or different and each independently representing halogen, C1-6 alkoxy, C1-6 alkyl, deuterated C1-6 alkyl or halogenated C1-6 alkyl; p19 represents an integer of 1, 2, 3 or 4; (R46)p20 indicates that the benzene ring in Formula (PBM-19) is substituted with p20 R46, with each R46 being the same or different and each independently representing halogen, C1-6 alkoxy, C1-6 alkyl, deuterated C1-6 alkyl, or halogenated C1-6 alkyl; p20 represents an integer of 1, 2, 3, 4 or 5; R47 represents halogen, C1-6 alkyl, deuterated C1-6 alkyl, or halogenated C1-6 alkyl; (R48)p21 indicates that the quinoline ring in Formula (PBM-20) is substituted with p21 R48, with each R48 being the same or different and each independently representing halogen, cyano, C1-6 alkoxy, C1-6 alkyl, deuterated C1-6 alkyl, or halogenated C1-6 alkyl; p21 represents an integer of 1, 2, 3 or 4; (R49)p22 indicates that the benzene ring in Formula (PBM-20) is substituted with p22 R49, with each R49 being the same or different and each independently representing halogen, C1-6 alkoxy, C1-6 alkyl, deuterated C1-6 alkyl, or halogenated C1-6 alkyl; p22 represents an integer of 2, 3 or 4; R50 in Formula (PBM-21) represents -NHC(O)- or -C(O)NH-; R51 represents -NH- or ethynylene; (R52)p23 indicates that the benzene rings in Formula (PBM-21) are each optionally substituted with p23 R52, with each R52 being the same or different and each independently representing halogen, C1-6 alkoxy, C1-6 alkyl, deuterated C1-6 alkyl, or halogenated C1-6 alkyl; each p23 is the same or different and each independently represents an integer of 0, 1, 2, 3 or 4; ring D in Formula (PBM-21) represents 5- to 20-membered monocyclic or bicyclic heteroaryl containing from 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur, and (R53)p24 indicates that the ring D is optionally substituted with p24 R53, with each R53 being the same or different and each independently representing optionally substituted 5- to 15-membered heteroaryl, deuterium, halogen, hydroxy, cyano, amino, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy; p24 represents an integer of 0, 1, 2, or 3; only one of R54, R55, R56, and R57 in Formula (PBM-22) represents a bond, and the remaining are the same or different and each independently represent hydrogen, halogen, or hydroxy, wherein when one of R54, R55, R56 and R57 represents a bond, the benzene ring or methylene in Formula (PBM-22) connected to the bond is directly connected to Rf; symbol "" connected to double bond in Formula (PBM-22) represents a bond in stereo-configuration (cis or trans configuration, or E- or Z-configuration); X13 in Formula (PBM-23) represents -O- or -CH2-; (R58)p25 indicates that 1,2,3,4-tetrahydronaphthalene ring in Formula (PBM-23) is substituted with p25 R58, with each R58 being the same or different and each independently representing hydrogen, hydroxy, halogen, C1-6 alkyl, halogenated C1-6 alkyl, or deuterated C1-6 alkyl; p25 represents an integer of 1, 2, 3 or 4; one of R59 and R60 represents a bond, and another represents hydrogen, halogen, C1-6 alkyl, deuterated C1-6 alkyl or halogenated C1-6 alkyl, wherein when one of R59 and R60 represents a bond, the carbon atom on the ring in Formula (PBM-23) connected to the bond is directly connected to Rf; ring E in Formula (PBM-24) represents 5- to 20-membered monocyclic or bicyclic heteroarylene containing from 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur; R62 represents optionally substituted 5- to 15-membered heteroaryl, optionally substituted 5- to 15-membered heterocyclyl, deuterium, halogen, hydroxy, cyano, amino, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy; R61 represents halogen, C1-6 alkyl, halogenated C1-6 alkyl, or deuterated C1-6 alkyl; R63 in Formula (PBM-25) represents optionally substituted 5- to 15-membered heterocyclyl, deuterium, halogen, hydroxy, cyano, amino, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy; R64 represents 5- to 20-membered monocyclic or bicyclic heteroaryl containing from 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur, and the heteroaryl is optionally substituted with one or more substituents selected from the group consisting of deuterium, halogen, hydroxy, cyano, amino, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, or any combination thereof; (R65)p26 indicates that the isoquinoline ring in Formula (PBM-26) is substituted with p26 R65, with each R65 being the same or different and each independently representing hydrogen, hydroxy, halogen, C1-6 alkyl, C1-6 alkoxy, -C(O)NH2, deuterated C1-6 alkyl, or halogenated C1-6 alkyl; p26 represents an integer of 1, 2, 3 or 4; groups R66 are the same or different and each independently represent hydrogen, hydroxy, halogen, C1-6 alkyl, C1-6 alkoxy, deuterated C1-6 alkyl, or halogenated C1-6 alkyl; X14 in Formula (PBM-27) represents N or CRb23, where Rb23 represents hydrogen or halogen, and X15 represents N or CH; R67 represents a bond, -C(O)NH- or -NHC(O)-; R68 represents halogen, C1-6 alkyl, deuterated C1-6 alkyl, or halogenated C1-6 alkyl; R69 represents hydrogen, C1-6 alkyl, deuterated C1-6 alkyl, halogenated C1-6 alkyl, or -C1-3 alkylene-C3-6 cycloalkyl; R70 represents hydrogen, C1-6 alkyl, deuterated C1-6 alkyl, or halogenated C1-6 alkyl; or R69 and R70 together with the corresponding nitrogen and carbon atoms to which they are connected form an optionally substituted 5- to 7-membered nitrogen-containing heterocycle; R71 represents hydrogen or a bond, R72 represents hydrogen or a bond, wherein R71 and R72 are not simultaneously hydrogen, and only one of R71 and R72 represents a bond, and another represents hydrogen, wherein when R71 represents a bond, the carbon atom on the ring connected to R71 is directly connected to Rf, and when R72 represents a bond, the carbon atom on the ring connected to R72 is directly connected to Rf; R74 in Formula (PBM-28) represents a bond, C1-3 alkylene or halogenated C1-3 alkylene; R73 represents optionally substituted C3-6cycloalkyl, halogenated C3-6 cycloalkyl, or optionally substituted C1-6 alkyl; R75 in Formula (PBM-29) represents C1-3 alkylene or halogenated C1-3 alkylene; R76 represents C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, or optionally substituted C3-6 cycloalkyl; R77 in Formula (PBM-30) represents C1-3 alkylene or halogenated C1-3 alkylene; R78 represents hydroxy, halogen, C1-6 alkyl, C1-6 alkoxy, deuterated C1-6 alkyl, or halogenated C1-6 alkyl; R79 and R80 are the same or different and each independently represent hydrogen, optionally substituted C1-10 alkyl or optionally substituted C3-6 cycloalkyl; R81 represents hydrogen, halogen, C1-6 alkyl, deuterated C1-6 alkyl, or halogenated C1-6 alkyl; X16 in Formula (PBM-31) represents -S- or a fragment wherein when X16 represents -S-, heteroaryl containing X16 and nitrogen atom in Formula (PBM-31) is thiazolyl, and when X16 represents the fragment the heteroaryl containing X16 and nitrogen atom in Formula (PBM-31) is pyridyl; X17 represents N or CH; R82 represents hydrogen or optionally substituted C1-10 alkyl; R83 represents hydrogen, -C1-3 alkylene-optionally substituted 4- to 10-membered heterocyclyl, or optionally substituted 4- to 10-membered heterocyclyl; R84 represents hydroxy, halogen, C1-6 alkyl, C1-6 alkoxy, deuterated C1-6 alkyl, or halogenated C1-6 alkyl; R85 and R86 in Formula (PBM-32) are the same or different and each independently represent hydroxy, halogen, C1-6 alkyl, C1-6 alkoxy, deuterated C1-6 alkyl, or halogenated C1-6 alkyl; R87 represents -S(O)2NH2 or -C(O)NH2; R88 in Formula (PBM-33) represents hydrogen, hydroxy, halogen, C1-6 alkyl, deuterated C1-6 alkyl, or halogenated C1-6 alkyl; R89 represents C1-6 alkyl, deuterated C1-6 alkyl, or halogenated C1-6 alkyl; or R88 and R89 together with the corresponding carbon and nitrogen atoms to which they are connected form an optionally substituted 4- to 6-membered heteroaromatic ring or optionally substituted 4- to 6-membered heterocycle; R90 represents optionally substituted C3-6 cycloalkyl, C1-6 alkyl, deuterated C1-6 alkyl, halogenated C1-6 alkyl or optionally substituted 4- to 10-membered heterocyclyl; (R91)p27 incicates that pyridin-2(1H)-one ring in Formula (PBM-33) is substituted with p27 R91, with each R91 being the same or different and each independently representing hydroxy, halogen, C1-6 alkyl, C1-6 alkoxy, deuterated C1-6 alkyl, or halogenated C1-6 alkyl; p27 represents an integer of 1, 2 or 3; ring F in Formula (PBM-33) represents arylene or 5- to 20-membered monocyclic or bicyclic heteroarylene containing from 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur; (R92)p28 incicates that the ring F is optionally substituted with p28 R92, with each R92 being the same or different and each independently representing deuterium, halogen, hydroxy, cyano, amino, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy; p28 represents an integer of 0, 1, 2, 3 or 4; (R93)p29 indicates that the benzene ring in Formula (PBM-34) is substituted with p29 R93, with each R93 being the same or different and each independently representing hydroxy, amino, cyano, halogen, C1-6 alkyl, C1-6 alkoxy, deuterated C1-6 alkyl, or halogenated C1-6 alkyl; p29 represents an integer of 1, 2, 3, 4 or 5; R94 represents hydrogen, hydroxy, amino, cyano, halogen, C1-6 alkyl, C1-6 alkoxy, deuterated C1-6 alkyl, or halogenated C1-6 alkyl; R95 represents NRb15Rb16, where Rb15 and Rb16 are the same or different and each independently represent hydrogen, C1-6 alkyl, deuterated C1-6 alkyl, halogenated C1-6 alkyl, optionally substituted C3-6 cycloalkyl, or optionally substituted 4- to 8-membered heterocyclyl ; X18, X19 and X20 in Formula (PBM-35) are the same or different and each independently represent CH or N, wherein X18, X19 and X20 are not simultaneously N, and the 6-membered ring containing X18, X19, X20 and nitrogen atom is optionally substituted with 1 or 2 substituents selected from the group consisting of halogen, cyano, C1-6 alkyl, deuterated C1-6 alkyl, halogenated C1-6 alkyl, or any combination thereof; X21 and X22 in Formula (PBM-35) are the same or different and each independently represent C or N, wherein X21 and X22 are not simultaneously N; (R96)p30 indicates that the benzene ring in Formula (PBM-35) is substituted with p30 R96, with each R96 being the same or different and each independently representing hydroxy, amino, cyano, halogen, C1-6 alkyl, C1-6 alkoxy, deuterated C1-6 alkyl, or halogenated C1-6 alkyl; p30 represents an integer of 1, 2, 3, 4 or 5; (R97)p31 indicates that the pyrrolidine ring in Formula (PBM-35) is optionally substituted with p31 R97, with each R97 being the same or different and each independently representing hydrogen, hydroxy, amino, cyano, halogen, C1-6 alkyl, C1-6 alkoxy, deuterated C1-6 alkyl, or halogenated C1-6 alkyl; p31 represents an integer of 0, 1, 2, 3, 4, 5 or 6; R98, R99, and R100 are the same or different and each independently represent hydrogen, halogen, C1-6 alkyl, deuterated C1-6 alkyl, or halogenated C1-6 alkyl; X23 in Formula (PBM-36) represents CH or N; R101 represents a bond or -S-; R102 represents a bond or optionally substituted 4- to 15-membered nitrogen-containing heterocyclyl; R103 represents a bond, halogen, amino, C1-6 alkyl, deuterated C1-6 alkyl, halogenated C1-6 alkyl, or optionally substituted 4- to 15-membered nitrogen-containing heterocyclyl; wherein R102 and R103 are not simultaneously a bond, and only one of R102 and R103 is a bond, wherein when R102 represents a bond, the carbon atom on the ring connected to R102 is directly connected to Rf, and when R103 represents a bond, the carbon atom on the ring connected to R103 is directly connected to Rf; (R104)p32 indicates that the 6-membered ring in Formula (PBM-36) is optionally substituted with p32 R104, with each R104 being the same or different and each independently representing hydroxy, amino, cyano, halogen, C1-6 alkyl, C1-6 alkoxy, deuterated C1-6 alkyl, or halogenated C1-6 alkyl; p32 represents an integer of 0, 1, 2, 3 or 4; (R105)p33 indicates that the benzene ring in Formula (PBM-37) is optionally substituted with p33 R105, with each R105 being the same or different and each independently representing hydroxy, amino, cyano, halogen, C1-6 alkyl, C1-6 alkoxy, deuterated C1-6 alkyl, or halogenated C1-6 alkyl; p33 represents an integer of 1, 2, 3 or 4; (R106)p34 indicates that the phthalazinone ring in Formula (PBM-37) is optionally substituted with p34 R106, with each R106 being the same or different and each independently representing hydroxy, amino, cyano, halogen, C1-6 alkyl, C1-6 alkoxy, deuterated C1-6 alkyl or halogenated C1-6 alkyl; p34 represents an integer of 0, 1, 2, 3 or 4; (R107)p35 indicates that the 2H-indazole ring in Formula (PBM-38) is optionally substituted with p35 R107, with each R107 being the same or different and each independently representing hydroxy, amino, cyano, halogen, C1-6 alkyl, C1-6 alkoxy, deuterated C1-6 alkyl or halogenated C1-6 alkyl; p35 represents an integer of 0, 1, 2 or 3; (R108)p36 indicates that the benzene ring in Formula (PBM-38) is optionally substituted with p36 R108, with each R108 being the same or different and each independently representing hydroxy, amino, cyano, halogen, C1-6 alkyl, C1-6 alkoxy, deuterated C1-6 alkyl or halogenated C1-6 alkyl; p36 represents an integer of 0, 1, 2 or 3; (R109)p37 indicates that the 2H-indazole ring in Formula (PBM-39) is optionally substituted with p37 R109, with each R109 being the same or different and each independently representing hydroxy, amino, cyano, halogen, C1-6 alkyl, C1-6 alkoxy, deuterated C1-6 alkyl or halogenated C1-6 alkyl; p37 represents an integer of 0, 1, 2 or 3; (R110)p38 indicates that the benzene ring in Formula (PBM-39) is optionally substituted with p38 R110, with each R110 being the same or different and each independently representing hydroxy, amino, cyano, halogen, C1-6 alkyl, C1-6 alkoxy, deuterated C1-6 alkyl or halogenated C1-6 alkyl; p38 represents an integer of 0, 1, 2 or 3; (R111)p39 indicates that the benzene ring in Formula (PBM-40) is optionally substituted with p39 R111, with each R111 being the same or different and each independently representing hydroxy, amino, cyano, halogen, C1-6 alkyl, C1-6 alkoxy, deuterated C1-6 alkyl or halogenated C1-6 alkyl; p39 represents an integer of 0, 1, 2, 3 or 4; R112, R113, and R114 are the same or different and each independently represent hydrogen, halogen, C1-6 alkyl, deuterated C1-6 alkyl or halogenated C1-6 alkyl; R115 in Formula (PBM-41) represents hydrogen, C1-6 alkyl, deuterated C1-6 alkyl or halogenated C1-6 alkyl; R116, R117, and R118 are the same or different and each independently represent hydrogen, halogen, C1-6 alkyl, deuterated C1-6 alkyl or halogenated C1-6 alkyl; (R119)p40 indicates that the benzene ring in Formula (PBM-41) is optionally substituted with p40 R119, with each R119 being the same or different and each independently representing hydroxy, amino, cyano, halogen, C1-6 alkyl, C1-6 alkoxy, deuterated C1-6 alkyl or halogenated C1-6 alkyl; p40 represents an integer of 0, 1, 2, 3 or 4; R120 and R121 in Formula (PBM-42) are the same or different and each independently represent hydrogen, halogen, C1-3 alkyl or halogenated C1-3 alkyl; R122 represents a bond, hydrogen, C1-6 alkyl, deuterated C1-6 alkyl or halogenated C1-6 alkyl; R123 represents the structure of the following formula: wherein R124 represents a bond or hydrogen; (R125)p41 indicates that the benzene ring is optionally substituted with p41 R125, with each R125 being the same or different and each independently representing hydroxy, amino, cyano, halogen, C1-6 alkyl, C1-6 alkoxy, deuterated C1-6 alkyl or halogenated C1-6 alkyl, and p41 represents an integer of 0, 1, 2, 3 or 4; or R123 represents the structure of the following formula: wherein (R126)p42 indicates that the benzene ring is optionally substituted with p42 R126, with each R126 being the same or different and each independently representing hydroxy, amino, cyano, halogen, C1-6 alkyl, C1-6 alkoxy, deuterated C1-6 alkyl or halogenated C1-6 alkyl, and p42 represents an integer of 0, 1, 2, 3, 4 or 5; wherein R122 and R124 are not simultaneously a bond, and only one of R122 and R124 represents a bond, wherein when R122 represents a bond, the nitrogen atom on the ring connected to R122 is directly connected to Rf, and when R124 represents a bond, the carbon atom on the ring connected to R124 is directly connected to Rf; (R127)p43 indicates that the benzene ring in Formula (PBM-43) is optionally substituted with p43 R127, with each R127 being the same or different and each independently representing hydroxy, amino, cyano, halogen, C1-6 alkyl, C1-6 alkoxy, deuterated C1-6 alkyl or halogenated C1-6 alkyl; p43 represents an integer of 0, 1, 2, 3 or 4; R131 in Formula (PBM-45) represents C1-6 alkyl, deuterated C1-6 alkyl, halogenated C1-6 alkyl or hydrogen; R132 represents C1-6 alkyl, deuterated C1-6 alkyl, halogenated C1-6 alkyl, optionally substituted C3-6 cycloalkyl, optionally substituted 4- to 8-membered nitrogen-containing heterocyclyl or NRb17Rb18, where Rb17 and Rb18 are the same or different and each independently represent hydrogen, C1-6 alkyl, deuterated C1-6 alkyl or optionally substituted 4- to 8-membered heterocyclyl; (R133)p46 indicates that the benzene ring in Formula (PBM-45) is optionally substituted with p46 R133, with each R133 being the same or different and each independently representing hydroxy, amino, cyano, halogen, C1-6 alkyl, C1-6 alkoxy, deuterated C1-6 alkyl or halogenated C1-6 alkyl; p46 represents an integer of 0, 1, 2, 3 or 4; (R134)p47 indicates that the benzene ring in Formula (PBM-46) is optionally substituted with p47 R134, with each R134 being the same or different and each independently representing hydroxy, amino, cyano, halogen, C1-6 alkyl, C1-6 alkoxy, deuterated C1-6 alkyl or halogenated C1-6 alkyl; p47 represents an integer of 0, 1, 2, 3 or 4; (R135)p48 indicates that the benzene ring in Formula (PBM-46) is optionally substituted with p48 R135, with each R135 being the same or different and each independently representing hydroxy, amino, cyano, halogen, C1-6 alkyl, C1-6 alkoxy, deuterated C1-6 alkyl or halogenated C1-6 alkyl; p48 represents an integer of 0, 1, 2, 3 or 4; ring H in Formula (PBM-48) represents C6-10 arylene or C5-10 heteroarylene, and (R137)p49 indicates that the ring H is optionally substituted with p49 R137, with each R137 being the same or different and each independently representing deuterium, halogen, hydroxy, cyano, amino, nitro, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy; p49 represents an integer of 0, 1, 2, 3 or 4; R136 represents optionally substituted 5- to 20-membered monocyclic or bicyclic heteroaryl containing from 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur, which is optionally substituted with a substituent selected from the group consisting of hydroxy, amino, cyano, halogen, C1-6 alkyl, C1-6 alkoxy, deuterated C1-6 alkyl or halogenated C1-6 alkyl; X24, X25, and X26 in Formula (PBM-49) each independently represents CH or N; R138 represents -C(O)NHRb19, -NHC(O)-Rb19, -S(O)2NHRb19, -NHS(O)2Rb19, -S(O)2Rb19 or - P(O)(Rb19)2, wherein each Rb19 is the same or different and each independently represents C1-6 alkyl or deuterated C1-6 alkyl; R139 and R140 each independently represent halogen, hydroxy, cyano, amino, nitro, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy; (R141)p50 indicates that the benzene ring is optionally substituted with p50 R141, with each R141 being independently halogen, hydroxy, cyano, amino, nitro, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy; p50 represents an integer of 0, 1, 2, 3 or 4; and (R143)p51 in Formula (PBM-50) indicates that the benzene ring is optionally substituted with p51 R143, with each R143 being independently halogen, hydroxy, cyano, amino, nitro, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy; p51 represents an integer of 0, 1, 2, 3, 4 or 5; R142 represents H, C1-6 alkyl or halogenated C1-6 alkyl; (R144)p52 indicates that the quinazoline ring in Formula (PBM-50) is optionally substituted with p52 R144, with each R144 being independently halogen, hydroxy, cyano, amino, nitro, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy, and p52 represents an integer of 1, 2, or 3; Rf2 in Formula (PBM-51) represents a bond, or Rf2 represents -NH-Rf3-C(O)-***, wherein symbol *** indicates the point of attachment to Rf1, and Rf3 represents optionally substituted C3-8 cycloalkyl; (R145)p53 indicates that the 1H-pyrrolo[2,3-b]pyridine ring in Formula (PBM-51) is optionally substituted with p53 R145, with each R145 being independently cyano, halogen, hydroxy, amino, nitro, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy, and p53 represents an integer of 0, 1, 2, 3, 4 or 5; (R146)p54 indicates that the pyridine ring in Formula (PBM-51) is optionally substituted with p54 R146, with each R146 being independently cyano, halogen, hydroxy, nitro, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy or NRb25Rb26, wherein Rb25 and Rb26 are the same or different and each independently represent hydrogen, C1-6 alkyl, deuterated C1-6 alkyl, halogenated C1-6 alkyl, optionally substituted C3-6 cycloalkyl or optionally substituted 4- to 8-membered heterocyclyl, and p54 represents an integer of 0, 1, 2 or 3; and (R147)p55 in Formula (PBM-52) indicates that the benzene ring is optionally substituted with p55 R147, with each R147 being independently halogen, hydroxy, cyano, amino, nitro, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy or halogenated C1-6 alkoxy, and p55 represents an integer of 0, 1, 2, 3, 4 or 5; R148 represents NHC(O) or C(O)NH; (R149)p56 indicates that the 1H-pyrazole ring in Formula (PBM-52) is optionally substituted with p56 R149, with each R149 being independently halogen, hydroxy, cyano, amino, nitro, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy or halogenated C1-6 alkoxy, and p56 represents an integer of 0, 1 or 2; and X27 in Formula (PBM-53) represents N or CH; R150 represents a bond or optionally substituted methylene (e.g., halogenated methylene); ring I represents C6-10 arylene or 5- to 15-membered heteroarylene, and (R151)p57 indicates that the ring I is optionally substituted with p57 R151, with each R151 being the same or different and each independently representing deuterium, halogen, hydroxy, cyano, amino, nitro, oxo, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy, and p57 represents an integer of 0, 1, 2, 3 or 4; (R152)p58 indicates that the 6-membered ring containing X27 in Formula (PBM-53) is optionally substituted with p58 R152, with each R152 independently representing halogen, C1-6 alkoxy, C1-6 alkyl, deuterated C1-6 alkyl or halogenated C1-6 alkyl, and p58 represents an integer of 0, 1 or 2; (R153)p59 indicates that the benzene ring in Formula (PBM-53) is optionally substituted with p59 R153, with each R153 being the same or different and each independently representing halogen, C1-6 alkoxy, C1-6 alkyl, deuterated C1-6 alkyl or halogenated C1-6 alkyl, and p15 represents an integer of 0, 1, 2, 3 or 4; X28, X29 and X30 in Formula (PBM-54) independently represent N or CH; (R154)p60 indicates that the naphthyl in Formula (PBM-54) is optionally substituted with p60 R154, with each R154 independently representing halogen, hydroxy, amino, mercapto, nitro, cyano, C2-6 alkynyl, C2-6 alkenyl, C1-6 alkoxy, C1-6 alkyl or halogenated C1-6 alkyl, and p60 represents an integer of 0, 1, 2, 3, 4, 5, 6 or 7; R155 represents optionally substituted C3-11 cycloalkyl or optionally substituted 4- to 15-membered heterocyclyl containing from 1 to 4 heteroatoms selected from the group consisting of oxygen, nitrogen, and sulfur; R156 represents hydrogen, halogen, hydroxy, cyano, amino, mercapto, nitro, C2-6 alkynyl, C2-6 alkenyl, C1-6 alkoxy, C1-6 alkyl or halogenated C1-6 alkyl; R157 in Formula (PBM-55) represents C6-10 aryl, or heteroaryl containing one or two 5- to 7-membered rings and 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulfur, wherein the C6-10 aryl and heteroaryl are each optionally substituted with one or more substituents selected from the group consisting of halogen, hydroxy, mercapto, cyano, amino, nitro, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy; R158 represents 5- to 15-membered heteroaryl containing 1 to 4 heteroatoms selected from nitrogen, oxygen, and sulfur, wherein the 5- to 15-membered heteroaryl is optionally substituted with one or more substituents selected from the group consisting of halogen, hydroxy, mercapto, cyano, amino, nitro, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy; (R159)p61 indicates that the isoindolinone ring in Formula (PBM-55) is substituted with p61 R159, with each R159 being the same or different and each independently representing halogen, hydroxy, mercapto, cyano, amino, nitro, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy, and p61 represents an integer of 0, 1, 2 or 3; X31 in Formula (PBM-56) represents N or CH; (R160)p62 indicates that the aromatic ring containing X31 in Formula (PBM-56) is substituted with p62 R160, with each R160 being the same or different and each independently representing halogen, hydroxy, mercapto, cyano, amino, nitro, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy, and p62 represents an integer of 0, 1, 2, 3 or 4; and ring J represents 5- to 15-membered heteroarylene, and (R161)p63 indicates that the ring J is optionally substituted with p63 R161, with each R161 being the same or different and each independently representing halogen, hydroxy, mercapto, cyano, amino, nitro, C1-6 alkyl, halogenated C1-6 alkyl, deuterated C1-6 alkyl, hydroxy substituted C1-6 alkyl, C1-6 alkoxy, or halogenated C1-6 alkoxy, and p63 represents an integer of 0, 1, 2 or 3.

15. The compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 12, wherein PBM comprises the structure of formula selected from:

16. The compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 12, wherein Rf represents a bond, -O-, -NHC(O)-*, -C(O)NH-*, or -NH-, or Rf represents the structure of the following formula: -N(Rg)-, -NHC(O)-C1-6 alkylene-W5-*, -NHC(O)-C2-6 alkenylene-W5-*, -C(O)NH-C1-6 alkylene-W5-*, -C(O)NH-C2-6 alkenylene-W5-*, -NHC(O)-W5-*, -C(O)NH-W5-*, -O-C1-6 alkylene-W5-*, -O-C2-6 alkenylene-W5-*, -O-W5-*, -O-C1-6 alkylene-N(Ri)-*, -O-C2-6 alkenylene-N(Ri)-*, -N(Rg)-C1-6 alkylene-N(Ri)-*, -N(Rg)-C2-6 alkenylene-N(Ri)-*, -W5-, -W5-N(Rg)-*, -N(Rg)-W5-*, -N(Rg)-W5-N(Ri)-*, -C1-6 alkylene-W5-*, -C2-6 alkenylene-W5-*, -C1-6 alkylene -C(O)-W5-*, -C2-6 alkenylene-C(O)-W5-*, -C(O)-W5-*, -C1-6 alkylene-C(O)NH-C1-6 alkylene-W5-*, -C1-6 alkylene-C(O)NH-C2-6 alkenylene-W5-*, -C2-6 alkenylene-C(O)NH-C1-6 alkylene-W5-*, -C2-6 alkenylene-C(O)NH-C2-6 alkenylene-W5-*, -C1-6 alkylene-NHC(O)-C1-6 alkylene-W5-*, -C1-6 alkylene-NHC(O)-C2-6 alkenylene-W5-*, -C2-6 alkenylene-NHC(O)-C1-6 alkylene-W5-*, -C2-6 alkenylene-NHC(O)-C2-6 alkenylene-W5-*, -C1-6 alkylene-C(O)NH-*, -C2-6 alkenylene-C(O)NH-*, -C1-6 alkylene-NHC(O)-*, -C2-6 alkenylene-NHC(O)-*, -C1-6 alkylene-, -C2-6 alkenylene-, -C1-6 alkylene-N(Ri)-*, -C2-6 alkenylene-N(Ri)-*, wherein Rg and Ri each independently represent hydrogen or C1-6 alkyl, and the C1-6 alkylene and C2-6 alkenylene are optionally substituted with one or more substituents selected from the group consisting of halogen, hydroxy, mercapto, cyano, amino, nitro, C1-6 alkyl, halogenated C1-3 alkyl, C1-3 alkoxy, halogenated C1-3 alkoxy or any combination thereof; wherein W5 represents the structure of the following formula: wherein each rings W6 is the same or different and each independently represents nitrogen-containing heterocyclylene, t1 represents an integer of 1 or 2 , and (Ra2)m2 indicates that each ring W6 is optionally substituted with m2 Ra2 substituents, with each Ra2 being independently deuterium, optionally deuterated C1-6 alkyl, optionally halogenated C1-6 alkyl, C1-6 alkoxy, halogen, amino, hydroxy, mercapto, cyano, carboxyl, C2-6 alkynyl, C2-6 alkenyl, optionally deuterated C3-6 cycloalkyl, or R12a-R11a-, wherein R11a is optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, and R12a represents halogen, R13aR14aN-, hydroxy, carboxyl, ethynyl, or vinyl, wherein R13a and R14a are the same or different and each independently represent hydrogen or C1-3 alkyl, and the C1-6 alkylene and C2-6 alkenylene is optionally substituted with one or more substituents selected from the group consisting of halogen, hydroxy, mercapto, cyano, amino, nitro, C1-6 alkyl, halogenated C1-3 alkyl, C1-3 alkoxy, halogenated C1-3 alkoxy or any combination thereof, and m2 represents an integer of 0-20; each ring W7 is the same or different and each independently represents nitrogen-containing heterocyclylene, arylene, or heteroarylene, t2 represents an integer of 0 or 1, and (Ra3)m3 indicates that each ring W7 is independently optionally substituted with m3 Ra3 substituents, with each Ra3 being independently deuterium, optionally deuterated C1-6 alkyl, C1-6 alkoxy, halogen, amino, hydroxy, mercapto, cyano, carboxyl, C2-6 alkynyl, C2-6 alkenyl, optionally deuterated C3-6 cycloalkyl, or R16a-R15a-, wherein R15a is optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, and R16a represents halogen, R17aR18aN-, hydroxy, carboxyl, ethynyl, or vinyl, wherein R17a and R18a are the same or different and each independently represent hydrogen or C1-3 alkyl, and m3 represents an integer of 0-20; and symbol * indicates the point of attachment to LIN.

17. The compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 12, wherein Rf represents -W7-Rh-W5-*, wherein Rh represents optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, W5 and W7 are as defined in claim 12 or 16.

18. The compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in any one of claims 12 or 16-17, wherein W5 represents the structure of the following formula: wherein each ring W6 is the same or different and each independently represents 4- to 20-membered nitrogen-containing heterocyclylene, e.g., piperidinylene, piperazinylene, morpholinylene, azetidinylene, pyrrolidinylene, imidazolidylene, pyrazolidylene, oxazolidinylene, thiazolidinylene, thiomorpholinylene, azepanylene, diazacycloheptanylene, azacyclooctylene, diazacyclooctylene, azabicyclo[3.1.1]heptanylene, azabicyclo[2.2.1]heptanylene, azabicyclo[3.2.1]octanylene, azabicyclo[2.2.2]octanylene, diazabicyclo[3.1.1]heptanylene, diazabicyclo[2.2.1]heptanylene, diazabicyclo[3.2.1]octanylene, diazabicyclo[2.2.2]octanylene, 3-azaspiro[5.5]undecan-3-ylene, 8-azaspiro[4.5]decan-4-ylene, 2-oxa-8-azaspiro[4.5]decan-4-ylene, or 3-methyl-2-oxa-8-azaspiro[4.5]decan-4-ylene, or t1 represents an integer of 1 or 2, (Ra2)m2 indicates that each ring W6 is optionally substituted with m2 Ra2 substituents, with each Ra2 being independently deuterium, optionally deuterated C1-6 alkyl, optionally halogenated C1-6 alkyl, C1-6 alkoxy, halogen, amino, hydroxy, mercapto, cyano, carboxyl, C2-6 alkynyl, C2-6 alkenyl, optionally deuterated C3-6 cycloalkyl, or R12a-R11a-, wherein R11a is optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, and R12a represents halogen, R13aR14aN-, hydroxy, carboxyl, ethynyl, vinyl, wherein R13a and R14a are the same or different and each independently represent hydrogen or C1-3 alkyl, and the C1-6 alkylene and C2-6 alkenylene are optionally substituted with one or more substituents selected from the group consisting of halogen, hydroxy, mercapto, cyano, amino, nitro, C1-6 alkyl, halogenated C1-3 alkyl, C1-3 alkoxy, halogenated C1-3 alkoxy or any combination thereof, and m2 represents an integer of 0-20; each ring W7 is the same or different and each independently represents 4- to 15-membered nitrogen-containing heterocyclylene, 6- to 10-membered arylene, or 5- to 10-membered heteroarylene, e.g., piperidinylene, piperazinylene, morpholinylene, azetidinylene, pyrrolidinylene, imidazolidylene, pyrazolidylene, oxazolidinylene, thiazolidinylene, thiomorpholinylene, azepanylene, diazacycloheptanylene, azacyclooctylene, diazacyclooctylene, azabicyclo[3.

1. 1]heptanylene, azabicyclo[2.

2. 1]heptanylene, azabicyclo[3.

2. 1]octanylene, azabicyclo[2.2.2]octanylene, diazabicyclo[3.1.1]heptanylene, diazabicyclo[2.2.1]heptanylene, diazabicyclo[3.2.1]octanylene, diazabicyclo[2.2.2]octanylene, 3-azaspiro[5.5]undecan-3-ylene, 8-azaspiro[4.5]decan-4-ylene, 2-oxa-8-azaspiro[4.5]decan-4-ylene, or 3-methyl-2-oxa-8-azaspiro[4.5]decan-4-ylene, phenylene, naphthylene, furanylene, oxazolylene, isoxazolylene, oxadiazolylene, thienylene, thiazolylene, isothiazolylene, thiadiazolylene, pyrrolylene, imidazolylene, pyrazolylene, triazolylene, pyridylene, pyrimidinylene, pyridazinylene, pyrazinylene, indolylene, isoindolylene, benzofuranylene, isobenzofuranylene, benzothienylene, indazolylene, benzimidazolylene, benzoxazolylene, benzisoxazolylene, benzothiazolylene, benzisothiazolylene, benzotriazolylene, benzo[2,1,3]oxadiazolylene, benzo[2,1,3]thiadiazolylene, benzo[1,2,3]thiadiazolylene, quinolinylene, isoquinolinylene, naphthyridinylene, cinnolinylene, quinazolinylene, quinoxalinylene, phthalazinylene, pyrazolo[1,5-a]pyridylene, pyrazolo[1,5-a]pyrimidinylene, imidazo[1,2-a]pyridylene, 1H-pyrrolo[3,2-b]pyridylene, 1H-pyrrolo[2,3-b]pyridylene, pyrrolo[2,1-b]thiazolylene, and imidazo[2,1-b]thiazolylene, or t2 represents an integer of 0 or 1, (Ra3)m3 indicates that each ring W7 is optionally substituted with m3 Ra3 substituents, with each Ra3 being independently deuterium, optionally deuterated C1-6 alkyl, C1-6 alkoxy, halogen, amino, hydroxy, mercapto, cyano, carboxyl, C2-6 alkynyl, C2-6 alkenyl, optionally deuterated C3-6 cycloalkyl, or R16a-R15a-, wherein R15a is optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, and R16a represents halogen, R17aR18aN-, hydroxy, carboxyl, ethynyl, or vinyl, wherein R17a and R18a are the same or different and each independently represent hydrogen or C1-3 alkyl, and m3 represents an integer of 0-20; and symbol * indicates the point of attachment to LIN.

19. The compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 16 or 17, wherein W5 represents the following groups: wherein the groups are optionally substituted with one or more substituents selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally halogenated C1-6 alkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, deuterated C1-6 alkoxy, halogen, amino, hydroxy, mercapto, cyano, carboxyl, C2-6 alkynyl, C2-6 alkenyl, optionally deuterated C3-6 cycloalkyl, R12a-R11a-, or any combination thereof, wherein R11a is optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, R12a represents halogen, R13aR14aN-, hydroxy, carboxyl, ethynyl, or vinyl, wherein R13a and R14a are the same or different and each independently represent hydrogen or C1-3 alkyl; and symbol * indicates the point of attachment to LIN.

20. The compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in any one of claims 12 or 16-17, wherein Rf represents the following groups: a bond, -O-, -NHC(O)-*, -C(O)NH-*, -NH-, -N(CH3)-, -N(CH3)-(CH2)2-N(CH3)-*, -N(CH3)-(CH2)3-N(CH3)-*, -NH-(CH2)2-N(CH3)-*, -N(CH3)-(CH2)3-NH-*, -CH2-NHC(O)-*, -CH2-C(O)NH-*, -CH2-NH-*, -O-(CH2)2-N(CH3)-*, -O-(CH2)2-NH-*, or -CH2-N(CH3)-*, or wherein the groups are optionally substituted with one or more substituents selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally halogenated C1-6 alkyl, C1-6 alkoxy, halogen, amino, hydroxy, mercapto, cyano, carboxyl, C2-6 alkynyl, C2-6 alkenyl, optionally deuterated C3-6 cycloalkyl, R12a-R11a-, or any combination thereof, wherein R11a is optionally substituted C1-6 alkylene or optionally substituted C2-6 alkenylene, R12a represents halogen, R13aR14aN-, hydroxy, carboxyl, ethynyl, or vinyl, wherein R13a and R14a are the same or different and each independently represent hydrogen or C1-3 alkyl; and symbol * indicates the point of attachment to LIN.

21. The compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 12, wherein ULM represents the structure of the following Formula (ULM-1), Formula (ULM-2), Formula (ULM-3), Formula (ULM-4), Formula (ULM-5), Formula (ULM-6), Formula (ULM-7), Formula (ULM-8), Formula (ULM-9), Formula (ULM-10) , Formula (ULM-11), or Formula (ULM-12): wherein A represents CO, CH2 or CD2; R1, R2, R3 and R4 are the same or different and each independently represent hydrogen, deuterium, halogen, optionally deuterated C1-6 alkyl, optionally deuterated C1-6 alkoxy, or halogenated C1-6 alkyl; (Rb)n indicates that benzene ring is optionally substituted with n Rb substituents, with each Rb being the same or different and independently representing deuterium, halogen, hydroxy, mercapto, nitro, amino, cyano, optionally deuterated C1-6 alkyl, optionally deuterated C1-6 alkoxy, halogenated C1-6 alkyl, optionally substituted C3-6 cycloalkyl, C2-6 alkynyl, or C2-6 alkenyl; and N represents an integer of 0, 1, 2 or 3.

22. The compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 20, wherein ULM represents the structure of the following Formula (ULM-13), Formula (ULM-14), Formula (ULM-15), Formula (ULM-16), Formula (ULM-17), Formula (ULM-18), Formula (ULM-19), Formula (ULM-20), Formula (ULM-21), Formula (ULM-22) , Formula (ULM-23), or Formula (ULM-24): wherein A, (Rb)n, and Rb are as defined in claim 19.

23. The compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 20, wherein ULM represents the structure of the following formula:

24. The compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in any one of claims 12-22, wherein LIN represents the structure of the following formula: wherein R5 and R6 are the same or different and each independently represent: hydrogen, fluorine, chlorine, bromine, iodine, optionally substituted methyl, or optionally substituted linear or branched C2-30 alkyl, wherein one or more groups Rc and / or one or more groups Rd and / or any combination of one or more groups Rc and Rd are optionally inserted into the backbone carbon chain of the linear or branched C2-30 alkyl, wherein carbon-carbon bond between one or more pairs of adjacent carbon atoms in the backbone carbon chain is interrupted by the group Rc, Rd, or a combination of Rc and Rd; wherein each Rc is selected from the group consisting of O, N(Re), C(O), C(O)O, S(O), S(O)2, S(O)2NH, NHS(O)2, OC(O), C(O)N(Re), N(Re)C(O), or N(Re)C(O)N(Re), where each Re independently represents H or C1-6 alkyl, and in case that two or more groups Rc are inserted into the backbone carbon chain of the linear or branched C2-30 alkyl group, the two or more groups Rc are not directly connected to each other; and wherein each Rd is selected from the group consisting of cycloalkylene (e.g., C3-20 cycloalkylene), arylene (e.g., C3-20 arylene), heterocyclylene (e.g., 4- to 20-membered heterocyclylene), heteroarylene (e.g., 4- to 20-membered heteroarylene), alkynylene (e.g., C2-6 alkynylene), alkenylene (e.g., C2-6 alkenylene), or any combination thereof, wherein the cycloalkylene, arylene, heterocyclylene, and heteroarylene are independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, halogenated C1-6 alkyl, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, cyano, or any combination thereof; and a hydrogen atom of methyl and hydrogen atom of one or more CH2 of C2-30 alkyl are optionally substituted with a substituent selected from the group consisting of deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C1-6 alkyl, halogenated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, or any combination thereof.

25. The compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in any one of claims 12-22, wherein R5 and R6 are the same or different and each independently represent hydrogen, fluorine, chlorine, bromine, or iodine, or represent the structure of the following formula: -C1-30 alkyl; -(C(Ra4)(Ra5))n1-(Rc-(C(Ra6)(Ra7))n2)m4-H; -(C(Ra4)(Ra5))n1-(Rc-(C(Ra6)(Ra7))n2)m4-(Rc-(C(Ra8)(Ra9))n3)m5-H; -(C(Ra4)(Ra5))n1-(Rc-(C(Ra6)(Ra7))n2)m4-(Rc-(C(Ra8)(Ra9))n3)m5-(Rc-(C(Ra10)(Ra11))n4)m6-H; -(C(Ra4)(Ra5))n1-(Rd-(C(Ra6)(Ra7))n2)m4-H; -(C(Ra4)(Ra5))n1-(Rd-(C(Ra6)(Ra7))n2)m4-(Rd-(C(Ra8)(Ra9))n3)m5-H; -(C(Ra4)(Ra5))n1-(Rd-(C(Ra6)(Ra7))n2)m4-(Rd-(C(Ra8)(Ra9))n3)m5-(Rd-(C(R10)(Ra11))n4)m6-H; -(C(Ra4)(Ra5))n1-(Rc-Rd-(C(Ra6)(Ra7))n2)m4-CH3; -(C(Ra4)(Ra5))n1-(Rc-(C(Ra6)(Ra7))n2)m4-(Rd-(C(Ra8)(Ra9))n3)m5-H; -(C(Ra4)(Ra5))n1-(Rd-Rc-(C(Ra6)(Ra7))n2)m4-H; or -(C(Ra4)(Ra5))n1-(Rd-(C(Ra6)(Ra7))n2)m4-(Rc-(C(Ra8)(Ra9))n3)m5-H; wherein each Rc is selected from the group consisting of O, N(Re), C(O), C(O)O, OC(O), S(O), S(O)2, S(O)2NH, NHS(O)2, C(O)N(Re), N(Re)C(O), or N(Re)C(O)N(Re), wherein each Re independently represents H or C1-6 alkyl; and each Rd is selected from the group consisting of cycloalkylene (e.g., C3-20cycloalkylene), arylene (e.g., C3-20arylene), heterocyclylene (e.g., 4- to 20-membered heterocyclylene), heteroarylene (e.g., 4- to 20-membered heteroarylene), alkynylene (e.g., C2-6 alkynylene), alkenylene (e.g., C2-6 alkenylene ) or any combination thereof, wherein the cycloalkylene, arylene, heterocyclylene and heteroarylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, halogenated C1-6 alkyl, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, cyano or any combination thereof; a hydrogen atom of one or more CH2 of C1-30 alkyl is optionally substituted with a substituent selected from the group consisting of deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C1-6 alkyl, halogenated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, or any combination thereof; Ra4, Ra5, Ra6, Ra7, Ra8, Ra9, Ra10 and Ra11 each independently represent H, deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C1-6 alkyl, halogenated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, or optionally deuterated C1-6 alkyl-C(O)NH-; and n1, n2, n3, n4, m4, m5, and m6 each independently represent an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

26. The compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 12, wherein R5 and R6 are the same or different and each independently represent the structure of the following formula: - (C(Ra4)(Ra5))n1-(O-(C(Ra6)(Ra7))n2)m4-H; - (C(Ra4)(Ra5))n1-(O-(C(Ra6)(Ra7))n2)m4-(O-(C(Ra8)(Ra9))n3)m5-H; - (C(Ra4)(Ra5))n1-(O-(C(Ra6)(Ra7))n2)m4-(O-(C(Ra8)(Ra9))n3)m5-(O(C(Ra10)(Ra11))n4)m6-H; - (C(Ra4)(Ra5))n1-(N(Re)-(C(Ra6)(Ra7))n2)m4-H; - (C(Ra4)(Ra5))n1-(N(Re)-(C(Ra6)(Ra7))n2)m4-(N(Re)-(C(Ra8)(Ra9))n3)m5-H; - (C(Ra4)(Ra5))n1-(N(Re)-(C(Ra6)(Ra7))n2)m4-(N(Re)-(C(Ra8)(Ra9))n3)m5-(N(Re)-(C(Ra10)(Ra11))n4)m6-H; - (C(Ra4)(Ra5))n1-(C(O)N(Re)-(C(Ra6)(Ra7))n2)m4-H; - (C(Ra4)(Ra5))n1-(C(O)N(Re)-(C(Ra6)(Ra7))n2)m4-(C(O)N(Re)-(C(Ra8)(Ra9))n3)m5-H; - (C(Ra4)(Ra5))n1-(C(O)N(Re)-(C(Ra6)(Ra7))n2)m4-(C(O)N(Re)-(C(Ra8)(Ra9))n3)m5-(C(O)N(Re)-(C(Ra10)(Ra11))n4)m6-H; - (C(Ra4)(Ra5))n1-(C(O)N(Re)-(C(Ra6)(Ra7))n2)m4-(O-(C(Ra8)(Ra9))n3)m5-H; - (C(Ra4)(Ra5))n1-C(O)N(Re)-(C(Ra6)(Ra7))n2-(O-(C(Ra8)(Ra9))n3)m4-H; - (C(Ra4)(Ra5))n1-(N(Re)C(O)-(C(Ra6)(Ra7))n2)m4-H; - (C(Ra4)(Ra5))n1-(N(Re)C(O)-(C(Ra6)(Ra7))n2)m4-(O-(C(Ra8)(Ra9))n3)m5-H; - (C(Ra4)(Ra5))n1-(N(Re)C(O)-(C(Ra6)(Ra7))n2)m4-(O-(C(Ra8)(Ra9))n3)m5-(O-(C(Ra10)(Ra11))n4)m6-H; - (C(Ra4)(Ra5))n1-N(Re)C(O)-(C(Ra6)(Ra7))n2-(O-(C(Ra8)(Ra9))n3)m4-H; - (C(Ra4)(Ra5))n1-N(Re)C(O)N(Re)-(C(Ra6)(Ra7))n2-H; - (C(Ra4)(Ra5))n1-C(O)-(C(Ra6)(Ra7))n2-H; - (C(Ra4)(Ra5))n1-(arylene-(C(Ra6)(Ra7))n2)m4-H; - (C(Ra4)(Ra5))n1-(arylene-(C(Ra6)(Ra7))n2)m4-arylene-(C(Ra8)(Ra9))n3-H; - (C(Ra4)(Ra5))n1-(heterocyclylene-(C(Ra6)(Ra7))n2)m4-H; - (C(Ra4)(Ra5))n1-(heterocyclylene-(C(Ra6)(Ra7))n2)m4-(heterocyclylene-(C(Ra8)(Ra9))n3)m5-H; - (C(Ra4)(Ra5))n1-(heteroarylene-(C(Ra6)(Ra7))n2)m4-H; - (C(Ra4)(Ras))n1-(heteroarylene-(C(Ra6)(Ra7))n2)m4-(heteroarylene-(C(Ra8)(Ra9))n3)m5-H; - (C(Ra4)(Ra5))n1-(cycloalkylene-(C(Ra6)(Ra7))n2)m4-H; or - (C(Ra4)(Ra5))n1-(cycloalkylene-(C(Ra6)(Ra7))n2)m4-(cycloalkylene-(C(Ra8)(Ra9))n3)m5-H; wherein each Re independently represents H or C1-6 alkyl; the cycloalkylene, arylene, heterocyclylene and heteroarylene are each independently optionally substituted with one or more substituents selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, halogen, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, halogenated C1-6 alkyl, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, cyano or any combination thereof; Ra4, Ra5, Ra6, Ra7, Ra8, Ra9, Ra10 and Ra11 each independently represent H, deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C1-6 alkyl, halogenated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, or optionally deuterated C1-6 alkyl-C(O)NH-; and n1, n2, n3, n4, m4, m5, and m6 each independently represent an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

27. The compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 12, wherein R5 and R6 are the same or different and each independently represent the following groups: H, fluorine, chlorine, bromine, iodine, -CH3, -CH2-CH3, -(CH2)2-CH3, -(CH2)3-CH3, -(CH2)4-CH3, -(CH2)5-CH3, -(CH2)6-CH3, -(CH2)7-CH3, -(CH2)8-CH3, -(CH2)9-CH3, -(CH2)10-CH3, -(CH2)11-CH3,-(CH2)12-CH3, -(CH2)13-CH3, -(CH2)14-CH3, -(CH2)15-CH3, -(CH2)16-CH3, -(CH2)17-CH3, -(CH2)18-CH3, -(CH2)19-CH3, -(CH2)20-CH3, -(CH2)21-CH3, -(CH2)22-CH3, -(CH2)25-CH3, -(CH2)29-CH3;-CH2-O-CH3, -CH2-O-CH2-CH3, -CH2-O-(CH2)2-CH3, -(CH2)1-O-(CH2)3-CH3, -(CH2)1-O-(CH2)4-CH3, -(CH2)1-O-(CH2)5-CH3, -(CH2)1-O-(CH2)6-CH3, -(CH2)1-O-(CH2)7-CH3, -(CH2)1-O-(CH2)8-CH3, -(CH2)1-O-(CH2)9-CH3, -(CH2)1-O-(CH2)10-CH3, -(CH2)2-O-CH3, -(CH2)2-O-CH2-CH3, -(CH2)2-O-(CH2)2-CH3,-(CH2)2-O-(CH2)3-CH3, -(CH2)2-O-(CH2)4-CH3, -(CH2)2-O-(CH2)5-CH3, -(CH2)2-O-(CH2)6-CH3,-(CH2)2-O-(CH2)7-CH3, -(CH2)2-O-(CH2)8-CH3, -(CH2)2-O-(CH2)9-CH3, -(CH2)2-O-(CH2)10-CH3,-(CH2)2-O-(CH2)11-CH3, -(CH2)2-O-(CH2)12-CH3, -(CH2)3-O-CH3, -(CH2)3-O-CH2-CH3, -(CH2)3-O-(CH2)2-CH3, -(CH2)3-O-(CH2)3-CH3, -(CH2)3-O-(CH2)4-CH3, -(CH2)3-O-(CH2)5-CH3, -(CH2)3-O-(CH2)6-CH3, -(CH2)3-O-(CH2)7-CH3, -(CH2)4-O-CH3, -(CH2)4-O-CH2-CH3, -(CH2)4-O-(CH2)2-CH3,-(CH2)4-O-(CH2)3-CH3, -(CH2)4-O-(CH2)4-CH3, -(CH2)4-O-(CH2)5-CH3, -(CH2)4-O-(CH2)6-CH3,-(CH2)5-O-CH3, -(CH2)5-O-CH2-CH3, -(CH2)5-O-(CH2)2-CH3, -(CH2)5-O-(CH2)3-CH3, -(CH2)5-O-(CH2)4-CH3, -(CH2)5-O-(CH2)5-CH3, -(CH2)6-O-CH3, -(CH2)6-O-CH2-CH3, -(CH2)6-O-(CH2)2-CH3,-(CH2)6-O-(CH2)3-CH3, -(CH2)6-O-(CH2)4-CH3, -(CH2)7-O-CH3, -(CH2)7-O-CH2-CH3, -(CH2)7-O-(CH2)2-CH3, -(CH2)7-O-(CH2)3-CH3, -(CH2)8-O-CH3, -(CH2)8-O-CH2-CH3, -(CH2)8-O-(CH2)2-CH3,-CH(CH3)-O-CH3, -CH(CH3)-O-CH2-CH3, -CH(CH3)-O-(CH2)2-CH3, -CH(CH3)-O-(CH2)3-CH3,-CH(CH3)-O-(CH2)4-CH3, -CH(CH3)-O-(CH2)5-CH3, -CH(CH3)-O-(CH2)6-CH3, -CH(CH3)-O-(CH2)7-CH3, -CH(CH3)-O-(CH2)8-CH3, -CH(CH3)-O-(CH2)9-CH3, -CH(CH3)-O-(CH2)10-CH3, -CH2-(O(CH2)2)1-OCH2CH3, -CH2-(O(CH2)2)2-OCH2CH3, -CH2-(O(CH2)2)3-OCH2CH3, -CH2-(O(CH2)2)4-OCH2CH3, -CH2-(O(CH2)2)5-OCH2CH3, -CH2-(O(CH2)2)6-OCH2CH3, -CH2-(O(CH2)2)7-OCH2CH3,-CH2-(O(CH2)2)8-OCH2CH3, -CH2-(O(CH2)2)9-OCH2CH3, -CH2-(O(CH2)2)10-OCH2CH3, -CH2-(O(CH2)2)1-OCH3, -CH2-(O(CH2)2)2-OCH3, -CH2-(O(CH2)2)3-OCH3, -CH2-(O(CH2)2)4-OCH3, -CH2-(O(CH2)2)5-OCH3, -CH2-(O(CH2)2)6-OCH3, -CH2-(O(CH2)2)7-OCH3, -CH2-(O(CH2)2)8-OCH3, -CH2-(O(CH2)2)9-OCH3, -CH2-(O(CH2)2)10-OCH3, -(CH2)2-(O(CH2)2)1-OCH2CH3, -(CH2)2-(O(CH2)2)2-OCH2CH3, -(CH2)2-(O(CH2)2)3-OCH2CH3, -(CH2)2-(O(CH2)2)4-OCH2CH3, -(CH2)2-(O(CH2)2)5-OCH2CH3, -(CH2)2-(O(CH2)2)6-OCH2CH3, -(CH2)2-(O(CH2)2)7-OCH2CH3, -(CH2)2-(O(CH2)2)8-OCH2CH3, -(CH2)2-(O(CH2)2)9-OCH2CH3, -(CH2)2-(O(CH2)2)10-OCH2CH3, -(CH2)3-(O(CH2)2)1-OCH2CH3, -(CH2)3-(O(CH2)2)2-OCH2CH3, -(CH2)3-(O(CH2)2)3-OCH2CH3, -(CH2)3-(O(CH2)2)4-OCH2CH3, -(CH2)3-(O(CH2)2)5-OCH2CH3, -(CH2)3-(O(CH2)2)6-OCH2CH3, -(CH2)3-(O(CH2)2)7-OCH2CH3, -(CH2)3-(O(CH2)2)8-OCH2CH3, -(CH2)3-(O(CH2)2)9-OCH2CH3, -(CH2)3-(O(CH2)2)10-OCH2CH3, -(CH2)4-(O(CH2)2)1-OCH2CH3, -(CH2)4-(O(CH2)2)2-OCH2CH3, -(CH2)4-(O(CH2)2)3-OCH2CH3, -(CH2)4-(O(CH2)2)4-OCH2CH3, -(CH2)4-(O(CH2)2)5-OCH2CH3, -(CH2)4-(O(CH2)2)6-OCH2CH3, -(CH2)4-(O(CH2)2)7-OCH2CH3, -(CH2)4-(O(CH2)2)8-OCH2CH3, -(CH2)4-(O(CH2)2)9-OCH2CH3, -(CH2)4-(O(CH2)2)10-OCH2CH3, -CH2-(O(CH2)3)1-OCH2CH2CH3, -CH2-(O(CH2)3)2-OCH2CH2CH3, -CH2-(O(CH2)3)3-OCH2CH2CH3, -CH2-(O(CH2)3)4-OCH2CH2CH3, -CH2-(O(CH2)3)5-OCH2CH2CH3, -CH2-(O(CH2)3)6-OCH2CH2CH3, -CH2-(O(CH2)3)7-OCH2CH2CH3, -CH2-(O(CH2)3)8-OCH2CH2CH3, -CH2-(O(CH2)3)9-OCH2CH2CH3, -CH2-(O(CH2)3)10-OCH2CH2CH3, -(CH2)2-(O(CH2)3)1-OCH2CH2CH3, -(CH2)2-(O(CH2)3)2-OCH2CH2CH3, -(CH2)2-(O(CH2)3)3-OCH2CH2CH3,-(CH2)2-(O(CH2)3)4-OCH2CH2CH3, -(CH2)2-(O(CH2)3)5-OCH2CH2CH3, -(CH2)2-(O(CH2)3)6-OCH2CH2CH3, -(CH2)2-(O(CH2)3)7-OCH2CH2CH3, -(CH2)2-(O(CH2)3)8-OCH2CH2CH3, -(CH2)3-(O(CH2)3)1-OCH2CH2CH3, -(CH2)3-(O(CH2)3)2-OCH2CH2CH3, -(CH2)3-(O(CH2)3)3-OCH2CH2CH3,-(CH2)3-(O(CH2)3)4-OCH2CH2CH3, -(CH2)3-(O(CH2)3)5-OCH2CH2CH3, -(CH2)3-(O(CH2)3)6-OCH2CH2CH3, -(CH2)3-(O(CH2)3)7-OCH2CH2CH3, -(CH2)3-(O(CH2)3)8-OCH2CH2CH3, -CH2-O-(CH2)2-O-(CH2)2-CH3, -CH2-(O(CH2)2)2-(O(CH2)3)1-OCH2CH2CH3, -CH2-(O(CH2)2)3-(O(CH2)3)2-OCH2CH2CH3, -CH2-(O(CH2)2)4-(O(CH2)3)3-OCH2CH2CH3, -CH2-(O(CH2)2)5-(O(CH2)3)4-OCH2CH2CH3, -(CH2)2-O-(CH2)2-O-(CH2)2CH3, -(CH2)2-(O(CH2)2)2-(O(CH2)3)1-OCH2CH2CH3,-(CH2)2-(O(CH2)2)3-(O(CH2)3)2-OCH2CH2CH3, -(CH2)2-(O(CH2)2)4-(O(CH2)3)3-OCH2CH2CH3,-(CH2)2-(O(CH2)2)5-(O(CH2)3)4-OCH2CH2CH3, -(CH2)3-O-(CH2)2-O-(CH2)2CH3, -(CH2)3-(O(CH2)2)2-(O(CH2)3)1-OCH2CH2CH3, -(CH2)3-(O(CH2)2)3-(O(CH2)3)2-OCH2CH2CH3, -(CH2)3-(O(CH2)2)4-(O(CH2)3)3-OCH2CH2CH3, -(CH2)3-(O(CH2)2)5-(O(CH2)3)4-OCH2CH2CH3, -CH2-O-(CH2)3-O-CH2CH3, -CH2-(O(CH2)3)2-(O(CH2)2)1-O-CH2CH3, -CH2-(O(CH2)3)3-(O(CH2)2)2-O-CH2CH3, -CH2-(O(CH2)3)4-(O(CH2)2)3-O-CH2CH3, -CH2-(O(CH2)3)5-(O(CH2)2)4-O-CH2CH3, -(CH2)2-O-(CH2)3-O-CH2CH3, -(CH2)2-(O(CH2)3)2-(O(CH2)2)1-O-CH2CH3, -(CH2)2-(O(CH2)3)3-(O(CH2)2)2-O-CH2CH3,-(CH2)2-(O(CH2)3)4-(O(CH2)2)3-O-CH2CH3, -(CH2)2-(O(CH2)3)5-(O(CH2)2)4-O-CH2CH3, -(CH2)3-O-(CH2)3-O-CH2CH3, -(CH2)3-(O(CH2)3)2-(O(CH2)2)1-O-CH2CH3, -(CH2)3-(O(CH2)3)3-(O(CH2)2)2-O-CH2CH3, -(CH2)3-(O(CH2)3)4-(O(CH2)2)3-O-CH2CH3, -(CH2)3-(O(CH2)3)5-(O(CH2)2)4-O-CH2CH3,-CH2-O-(CH2)2-O-CH3, -(CH2)2-O-(CH2)2-O-CH3, -(CH2)2-(O(CH2)2)2-O-(CH2)2CH3, -(CH2)2-(O(CH2)2)3-O-(CH2)2CH3, -(CH2)2-(O(CH2)2)4-O-(CH2)2CH3, -(CH2)5-(O(CH2)2)2-O-(CH2)4CH3,-(CH2)5-(O(CH2)2)2-O-(CH2)5CH3, -(CH2)1-N(Re)-CH3, -(CH2)1-N(Re)-(CH2)1-CH3, -(CH2)1-N(Re)-(CH2)2-CH3, -(CH2)1-N(Re)-(CH2)3-CH3, -(CH2)1-N(Re)-(CH2)4-CH3, -(CH2)1-N(Re)-(CH2)5-CH3,-(CH2)1-N(Re)-(CH2)6-CH3, -(CH2)1-N(Re)-(CH2)7-CH3, -(CH2)1-N(Re)-(CH2)8-CH3, -(CH2)1-N(Re)-(CH2)9-CH3, -(CH2)2-N(Re)-CH3, -(CH2)2-N(Re)-(CH2)1-CH3, -(CH2)2-N(Re)-(CH2)2-CH3, -(CH2)2-N(Re)-(CH2)3-CH3, -(CH2)2-N(Re)-(CH2)4-CH3, -(CH2)2-N(Re)-(CH2)5-CH3, -(CH2)2-N(Re)-(CH2)6-CH3, -(CH2)2-N(Re)-(CH2)7-CH3, -(CH2)2-N(Re)-(CH2)8-CH3, -(CH2)2-N(Re)-(CH2)9-CH3, -(CH2)2-N(Re)-(CH2)10-CH3, -(CH2)2-N(Re)-(CH2)11-CH3, -(CH2)3-N(Re)-CH3, -(CH2)3-N(Re)-(CH2)1-CH3,-(CH2)3-N(Re)-(CH2)2-CH3, -(CH2)4-N(Re)-CH3, -(CH2)4-N(Re)-(CH2)1-CH3, -(CH2)4-N(Re)-(CH2)2-CH3, -(CH2)4-N(Re)-(CH2)3-CH3, -(CH2)5-N(Re)-CH3, -(CH2)5-N(Re)-(CH2)1-CH3, -(CH2)5-N(Re)-(CH2)2-CH3, -(CH2)5-N(Re)-(CH2)3-CH3, -(CH2)5-N(Re)-(CH2)4-CH3, -(CH2)6-N(Re)-CH3, -(CH2)6-N(Re)-(CH2)1-CH3, -(CH2)6-N(Re)-(CH2)2-CH3, -(CH2)7-N(Re)-CH3, -(CH2)7-N(Re)-(CH2)1-CH3,-(CH2)7-N(Re)-(CH2)2-CH3, -(CH2)8-N(Re)-CH3, -(CH2)8-N(Re)-(CH2)1-CH3, -(CH2)8-N(Re)-(CH2)2-CH3, -CH(CH3)-N(Re)-CH3, -CH(CH3)-N(Re)-(CH2)1-CH3, -CH(CH3)-N(Re)-(CH2)2-CH3, -CH(CH3)-N(Re)-(CH2)3-CH3, -CH(CH3)-N(Re)-(CH2)4-CH3, -CH(CH3)-N(Re)-(CH2)5-CH3, -CH(CH3)-N(Re)-(CH2)6-CH3, -CH(CH3)-N(Re)-(CH2)7-CH3, -CH(CH3)-N(Re)-(CH2)8-CH3, -CH(CH3)-N(Re)-(CH2)9-CH3, -CH2C(O)NHCH3, -(CH2)2C(O)NHCH2CH3, -(CH2)2C(O)NH(CH2)2-CH3,-(CH2)2C(O)NH(CH2)3-CH3, -(CH2)2C(O)NH(CH2)4-CH3, -(CH2)3C(O)NH(CH2)2-CH3,-(CH2)3C(O)NH(CH2)3-CH3, -(CH2)4C(O)NH(CH2)3-CH3, -(CH2)5C(O)NH(CH2)4-CH3,-(CH2)6C(O)NH(CH2)6-CH3, -(CH2)6C(O)NH(CH2)5-CH3, -(CH2)7C(O)NH(CH2)6-CH3,-(CH2)8C(O)NH(CH2)7-CH3, U-(CH2)9C(O)NH(CH2)8-CH3, -(CH2)10C(O)NH(CH2)9-CH3,-(CH2)2C(O)NH(CH2)2-O-CH2-CH3, -CH2NHC(O)CH3, -(CH2)2NHC(O)CH2CH3,-(CH2)2NHC(O)(CH2)2-CH3, -(CH2)2NHC(O)(CH2)3-CH3, -(CH2)2NHC(O)(CH2)4-CH3,-(CH2)3NHC(O)(CH2)2-CH3, -(CH2)3NHC(O)(CH2)3-CH3, -(CH2)4NHC(O)(CH2)3-CH3,-(CH2)5NHC(O)(CH2)4-CH3, -(CH2)6NHC(O)(CH2)6-CH3, -(CH2)6NHC(O)(CH2)5-CH3,-(CH2)7NHC(O)(CH2)6-CH3, -(CH2)8NHC(O)(CH2)7-CH3, -(CH2)9NHC(O)(CH2)8-CH3,-(CH2)10NHC(O)(CH2)9-CH3, -(CH2)4NHC(O)(CH2)7-CH3, -(CH2)2NHC(O)(CH2)2-O-CH2-CH3,-(CH2)4NHC(O)CH3, -CH2-piperidinylene-CH3, -CH2-piperidinylene-CH2-CH3, -CH2-piperidinylene-(CH2)2-CH3, -CH2-piperidinylene-(CH2)3-CH3, -CH2-piperidinylene-(CH2)4-CH3, -CH2-piperidinylene-(CH2)5-CH3, -CH2-piperidinylene-(CH2)6-CH3, -CH2-piperidinylene-(CH2)7-CH3,-(CH2)2-piperidinylene-CH3, -(CH2)2-piperidinylene-CH2-CH3, -(CH2)2-piperidinylene-(CH2)2-CH3,-(CH2)2-piperidinylene-(CH2)3-CH3, -(CH2)2-piperidinylene-(CH2)4-CH3, -(CH2)2-piperidinylene-(CH2)5-CH3, -(CH2)2-piperidinylene-(CH2)6-CH3, -(CH2)2-piperidinylene-(CH2)7-CH3, -(CH2)3-piperidinylene-CH3, -(CH2)3-piperidinylene-CH2-CH3, -(CH2)3-piperidinylene-(CH2)2-CH3, -(CH2)3-piperidinylene-(CH2)3-CH3, -(CH2)3-piperidinylene-(CH2)4-CH3, -(CH2)3-piperidinylene-(CH2)5-CH3, -(CH2)3-piperidinylene-(CH2)6-CH3, -(CH2)3-piperidinylene-(CH2)7-CH3, -(CH2)4-piperidinylene-CH3, -(CH2)4-piperidinylene-CH2-CH3, -(CH2)4-piperidinylene-(CH2)2-CH3, -(CH2)4-piperidinylene-(CH2)3-CH3, -(CH2)4-piperidinylene-(CH2)4-CH3, -(CH2)4-piperidinylene-(CH2)5-CH3, -(CH2)4-piperidinylene-(CH2)6-CH3, -(CH2)4-piperidinylene-(CH2)7-CH3, -(CH2)5-piperidinylene-CH3,-(CH2)5-piperidinylene-CH2-CH3, -(CH2)5-piperidinylene-(CH2)2-CH3, -(CH2)5-piperidinylene-(CH2)3-CH3, -(CH2)5-piperidinylene-(CH2)4-CH3, -(CH2)5-piperidinylene-(CH2)5-CH3, -(CH2)5-piperidinylene-(CH2)6-CH3, -(CH2)5-piperidinylene-(CH2)7-CH3, -(CH2)6-piperidinylene-CH3,-(CH2)6-piperidinylene-CH2-CH3, -(CH2)6-piperidinylene-(CH2)2-CH3, -(CH2)6-piperidinylene-(CH2)3-CH3, -(CH2)6-piperidinylene-(CH2)4-CH3, -(CH2)6-piperidinylene-(CH2)5-CH3, -(CH2)6-piperidinylene-(CH2)6-CH3, -(CH2)6-piperidinylene-(CH2)7-CH3, -(CH2)7-piperidinylene-CH3,-(CH2)7-piperidinylene-CH2-CH3, -(CH2)7-piperidinylene-(CH2)2-CH3, -(CH2)7-piperidinylene-(CH2)3-CH3, -(CH2)7-piperidinylene-(CH2)7-CH3, -(CH2)8-piperidinylene-CH3, -(CH2)8-piperidinylene-CH2-CH3, -(CH2)8-piperidinylene-(CH2)2-CH3, -(CH2)8-piperidinylene-(CH2)3-CH3, -(CH2)8-piperidinylene-(CH2)4-CH3, -(CH2)8-piperidinylene-(CH2)5-CH3, -(CH2)8-piperidinylene-(CH2)6-CH3, -(CH2)8-piperidinylene-(CH2)7-CH3, -CH2-N(Re)-CH2-piperidinylene-CH3, -CH2-N(Re)-CH2-piperidinylene-CH3, -CH2-N(Re)-CH2-piperidinylene-(CH2)2-CH3, -CH2-N(Re)-CH2-piperidinylene-(CH2)3-CH3, -CH2-N(Re)-CH2-piperidinylene-(CH2)4-CH3, -CH2-N(Re)-CH2-piperidinylene-(CH2)5-CH3, -CH2-N(Re)-CH2-piperidinylene-(CH2)6-CH3, -CH2-N(Re)-CH2-piperidinylene-(CH2)7-CH3,-CH2-N(Re)-(CH2)2-piperidinylene-CH3, -CH2-N(Re)-(CH2)2-piperidinylene-CH2-CH3, -CH2-N(Re)-(CH2)2-piperidinylene-(CH2)2-CH3, -CH2-N(Re)-(CH2)2-piperidinylene-(CH2)3-CH3, -CH2-N(Re)-(CH2)2-piperidinylene-(CH2)4-CH3, -CH2-N(Re)-(CH2)2-pipendinylene-(CH2)5-CH3, -CH2-N(Re)-(CH2)2-piperidinylene-(CH2)6-CH3, -CH2-N(Re)-(CH2)2-piperidinylene-(CH2)7-CH3, -(CH2)2-N(Re)-CH2-piperidinylene-CH3, -(CH2)2-N(Re)-CH2-piperidinylene-CH2-CH3, -(CH2)2-N(Re)-CH2-piperidinylene-(CH2)2-CH3, -(CH2)2-N(Re)-CH2-piperidinylene-(CH2)3-CH3, -(CH2)2-N(Re)-CH2-piperidinylene-(CH2)4-CH3, -(CH2)2-N(Re)-CH2-piperidinylene-(CH2)5-CH3, -(CH2)2-N(Re)-CH2-piperidinylene-(CH2)6-CH3, -(CH2)2-N(Re)-CH2-piperidinylene-(CH2)7-CH3, -(CH2)3-N(Re)-CH2-piperidinylene-CH3, -(CH2)3-N(Re)-CH2-piperidinylene-CH2-CH3, -(CH2)3-N(Re)-CH2-piperidinylene-(CH2)2-CH3, -(CH2)3-N(Re)-CH2-piperidinylene-(CH2)7-CH3, -(CH2)4-N(Re)-CH2-piperidinylene-CH3, -(CH2)4-N(Re)-CH2-piperidinylene-CH2-CH3, -(CH2)4-N(Re)-CH2-piperidinylene-(CH2)2-CH3,-(CH2)4-N(Re)-CH2-piperidinylene-(CH2)7-CH3, -(CH2)5-N(Re)-CH2-piperidinylene-(CH2)2-CH3,-(CH2)5-N(Re)-CH2-piperidinylene-(CH2)7-CH3, -(CH2)6-N(Re)-CH2-piperidinylene-(CH2)2-CH3,-(CH2)6-N(Re)-CH2-piperidinylene-(CH2)7-CH3, -(CH2)7-N(Re)-CH2-piperidinylene-(CH2)2-CH3,-(CH2)7-N(Re)-CH2-piperidinylene-(CH2)7-CH3, -(CH2)8-N(Re)-CH2-piperidinylene-CH3, -(CH2)8-N(Re)-CH2-piperidinylene-CH2-CH3, -(CH2)8-N(Re)-CH2-piperidinylene-(CH2)2-CH3, -(CH2)8-N(Re)-CH2-piperidinylene-(CH2)3-CH3, -(CH2)8-N(Re)-CH2-piperidinylene-(CH2)4-CH3, -(CH2)8-N(Re)-CH2-piperidinylene-(CH2)5-CH3, -(CH2)8-N(Re)-CH2-piperidinylene-(CH2)6-CH3, -(CH2)8-N(Re)-CH2-piperidinylene-(CH2)7-CH3, -CH2-piperazinylene-CH3, -CH2-piperazinylene-CH2-CH3, -CH2-piperazinylene-(CH2)2-CH3, -CH2-piperazinylene-(CH2)3-CH3, -CH2-piperazinylene-(CH2)4-CH3,-CH2-piperazinylene-(CH2)5-CH3, -CH2-piperazinylene-(CH2)6-CH3, -CH2-piperazinylene-(CH2)7-CH3, -(CH2)2-piperazinylene-CH3, -(CH2)2-piperazinylene-CH2-CH3, -(CH2)2-piperazinylene-(CH2)2-CH3,-(CH2)2-piperazinylene-(CH2)3-CH3, -(CH2)2-piperazinylene-(CH2)4-CH3, -(CH2)2-piperazinylene-(CH2)5-CH3, -(CH2)2-piperazinylene-(CH2)6-CH3, -(CH2)2-piperazinylene-(CH2)7-CH3, -(CH2)3-piperazinylene-CH3, -(CH2)3-piperazinylene-CH2-CH3, -(CH2)3-piperazinylene-(CH2)2-CH3, -(CH2)3-piperazinylene-(CH2)3-CH3, -(CH2)3-piperazinylene-(CH2)4-CH3, -(CH2)3-piperazinylene-(CH2)5-CH3, -(CH2)3-piperazinylene-(CH2)6-CH3, -(CH2)3-piperazinylene-(CH2)7-CH3, -(CH2)4-piperazinylene-CH3, -(CH2)4-piperazinylene-CH2-CH3, -(CH2)4-piperazinylene-(CH2)2-CH3, -(CH2)4-piperazinylene-(CH2)3-CH3, -(CH2)4-piperazinylene-(CH2)4-CH3, -(CH2)4-piperazinylene-(CH2)5-CH3, -(CH2)4-piperazinylene-(CH2)6-CH3, -(CH2)4-piperazinylene-(CH2)7-CH3, -(CH2)5-piperazinylene-CH3,-(CH2)5-piperazinylene-CH2-CH3, -(CH2)5-piperazinylene-(CH2)2-CH3, -(CH2)5-piperazinylene-(CH2)3-CH3, -(CH2)5-piperazinylene-(CH2)4-CH3, -(CH2)5-piperazinylene-(CH2)5-CH3, -(CH2)5-piperazinylene-(CH2)6-CH3, -(CH2)5-piperazinylene-(CH2)7-CH3, -(CH2)6-piperazinylene-CH3,-(CH2)6-piperazinylene-CH2-CH3, -(CH2)6-piperazinylene-(CH2)2-CH3, -(CH2)6-piperazinylene-(CH2)3-CH3, -(CH2)6-piperazinylene-(CH2)4-CH3, -(CH2)6-piperazinylene-(CH2)5-CH3, -(CH2)6-piperazinylene-(CH2)6-CH3, -(CH2)6-piperazinylene-(CH2)7-CH3, -(CH2)7-piperazinylene-CH3,-(CH2)7-piperazinylene-CH2-CH3, -(CH2)7-piperazinylene-(CH2)2-CH3, -(CH2)7-piperazinylene-(CH2)3-CH3, -(CH2)7-piperazinylene-(CH2)7-CH3, -(CH2)8-piperazinylene-CH3, -(CH2)8-piperazinylene-CH2-CH3, -(CH2)8-piperazinylene-(CH2)2-CH3, -(CH2)8-piperazinylene-(CH2)3-CH3, -(CH2)8-piperazinylene-(CH2)4-CH3, -(CH2)8-piperazinylene-(CH2)5-CH3, -(CH2)8-piperazinylene-(CH2)6-CH3, or -(CH2)8-piperazinylene-(CH2)7-CH3; wherein the piperidinylene and piperazinylene are each independently optionally substituted with a substituent selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, hydroxy, amino, mercapto, nitro, halogen, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, halogenated C1-6 alkyl, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, cyano or any combination thereof; a hydrogen atom of CH3 of the groups and a hydrogen atom of one or more CH2 of the groups are optionally substituted with a substituent selected from the group consisting of deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, optionally deuterated C1-6 alkyl, halogenated C1-6 alkyl, optionally deuterated C3-6 cycloalkyl, optionally deuterated C1-6 alkoxy, optionally deuterated C1-6 alkyl-NH-, NH2-C1-6 alkylene, optionally deuterated C1-6 alkyl-NHC(O)-, optionally deuterated C1-6 alkyl-C(O)NH-, or any combination thereof; each Re independently represents H or C1-6 alkyl; and n1, n2, n3, n4, m4, m5, and m6 each independently represent an integer of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

28. The compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in any one of claims 12-27, wherein -Rf-LIN-represents the following groups: -CH2-, -O-CH2-**, -NHC(O)-CH2-**, -C(O)NH-CH2-**, -NH-CH2-**, -N(CH3)-CH2-**,-N(CH3)-(CH2)2-N(CH3)-CH2-**, -N(CH3)-(CH2)3-N(CH3)-CH2-**, -NH-(CH2)2-N(CH3)-CH2-**,-N(CH3)-(CH2)3-NH-CH2-**, -CH2-NHC(O)-CH2-**, -CH2-C(O)NH-CH2-**, -CH2-NH-CH2-**, -O-(CH2)2-N(CH3)-CH2-**, -O-(CH2)2-NH-CH2-**, or -CH2-N(CH3) -CH2-**, or wherein the groups are optionally substituted with one or more substituents selected from the group consisting of deuterium, optionally deuterated C1-6 alkyl, optionally halogenated C1-6 alkyl, C1-6 alkoxy, halogenated C1-6 alkoxy, deuterated C1-6 alkoxy, halogen, amino, hydroxy, mercapto, cyano, carboxyl, C2-6 alkynyl, C2-6 alkenyl, optionally deuterated C3-6 cycloalkyl, or any combination thereof; and symbol ** indicates the point of attachment to ULM.

29. The compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 12, which is also of Formula (II-1), Formula (II-2), Formula (II-3), Formula (II-4), Formula (II-5), Formula (II-6), Formula (II-7), Formula (II-8), Formula (II-9), Formula (II-10), Formula (II-11), Formula (II-12), Formula (II-13), Formula (II-14), Formula (II-15), Formula (II-16), Formula (II-17), Formula (II-18), Formula (II-19), Formula (II-20), Formula (II-21), Formula (II-22), Formula (II-23), Formula (II-24), Formula (II-25), Formula (II-26), Formula (II-27), Formula (II-28), Formula (II-29), Formula (II-30), Formula (II-31), Formula (II-32), Formula (II-33), Formula (II-34), Formula (II-35), Formula (II-36), Formula (II-37), Formula (II-38), Formula (II-39), Formula (II-40), Formula (II-41), Formula (II-42), Formula (II-43), Formula (II-44), Formula (II-45), Formula (II-46), Formula (II-47), Formula (II-48), Formula (II-49), Formula (II-50), Formula (II-51), Formula (II-52), Formula (II-53), Formula (II-55), Formula (II-56), Formula (II-57), Formula (II-58), Formula (II-59), Formula (II-60), Formula (II-61), Formula (II-62), Formula (II-63), Formula (II-64), Formula (II-65), or Formula (II-66): wherein A, R1, R2, R3, R4, (Rb)n, LIN, Rf, (R1)p1, (R2)p2, (R4)p3, (R5)p4, (R7)p5, R8, (R9)p6, R10, (R11)p7, R12, R13, R14, ring A, ring B, ring C, R15, (R16)p9, X1, X2, X3, (R20)p10, R21, R22, (R23)p11, (R24)p12, R25, X4, X5, X6, X7, R28, R29, R30, R31, R32, R33, (R34)p13, R35, (R36)p14, R37, X8, X9, X10, X11, X12, R38, R39, (R40)p15, (R42)p16, (R43)p17, (R44)p18, (R45)p19, (R46)p20, (R48)p21, (R49)p22, R50, R51, (R52)p23, (R53)p24, R54, R55, R56, R57, (R58)p25, X13, R59, R60, R61, R62, R63, R64, (R65)p26, R66, R67, R68, R69, R70, X14, X15, R73, R74, R75, R76, R77, R78, R79, R80, R81, X16, X17, R82, R83, R84, R85, R86, R87, R88, R89, R90, (R91)p27, (R92)p28, (R93)p29, R94, R95, (R96)p30, (R97)p31, X18, X19, X20, X21, X22, R98, R99, R100, R101, R102, R103, X23, (R104)p32, (R105)p33, (R106)p34, (R107)p35, (R108)p36, (R109)p37, (R110)p38, (R111)p39, R112, R113, R114, R115, R116, R117, R118, (R119)p40, R120, R121, R122, R123, (R125)p41, (R127)p43, R131, R132, (R133)p46, (R134)p47, (R135)p48, R136, (R137)p49, X24, X25, X26, R138, R139, R140, (R141)p50, R142, (R143)p51, (R144)p52, (R145)p53, (R146)p54, Rf2, (R147)p55, R148, (R149)p56, X27, ring I, R150, (R151)p57, (R152)p58, (R153)p59, X28, X29, X30, (R154)p60, R155, R156, R157, R158, (R159)p61, X31, (R160)p62, ring J and (R161)p63 are as defined in claim 13.

30. The compound of Formula (II) or salts, enantiomers, stereoisomers, solvates, isotopically enriched analogs, prodrugs, or polymorphs thereof as claimed in claim 12, which is selected from: N-(2-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)ethyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carboxamide; N-(2-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)ethyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carboxamide; N-(2-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)ethyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carboxamide; N-(2-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)ethyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carboxamide; N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carboxamide; N-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carboxamide; N-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carboxamide; N-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carboxamide; ((2-(((5S,8S,10aR)-8-(((2S)-5-amino-1-(2-chloro-3-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-methyl-6-oxodecahydropyrrolo[1,2-a][1,5]diazocin-5-yl)carbamoyl)-1H-indol-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((2S)-5-amino-1-(2-chloro-3-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-methyl-6-oxodecahydropyrrolo[1,2-a][1,5]diazocin-5-yl)carbamoyl)-1H-indol-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((2S)-5-amino-1-(2-chloro-3-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-methyl-6-oxodecahydropyrrolo[1,2-a][1,5]diazocin-5-yl)carbamoyl)-1H-indol-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((2S)-5-amino-1-(2-chloro-3-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-methyl-6-oxodecahydropyrrolo[1,2-a][1,5]diazocin-5-yl)carbamoyl)-1H-indol-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((2S)-5-amino-1-(2-chloro-3-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-methyl-6-oxodecahydropyrrolo[1,2-a][1,5]diazocin-5-yl)carbamoyl)-1H-indol-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((2S)-5-amino-1-(2-chloro-3-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-methyl-6-oxodecahydropyrrolo[1,2-a][1,5]diazocin-5-yl)carbamoyl)-1H-indol-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((2S)-5-amino-1-(2-chloro-3-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-methyl-6-oxodecahydropyrrolo[1,2-a][1,5]diazocin-5-yl)carbamoyl)-1H-indol-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((2S)-5-amino-1-(2-chloro-3-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-methyl-6-oxodecahydropyrrolo[1,2-a][1,5]diazocin-5-yl)carbamoyl)-1H-indol-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((S)-5-amino-1-(benzhydrylamino)-1,5-dioxopentan-2-yl)carbamoyl)-3-((1-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)methyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocin-5-yl)carbamoyl)-1H-indol-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((S)-5-amino-1-(benzhydrylamino)-1,5-dioxopentan-2-yl)carbamoyl)-3-((1-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)methyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocin-5-yl)carbamoyl)-1H-indol-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((S)-5-amino-1-(benzhydrylamino)-1,5-dioxopentan-2-yl)carbamoyl)-3-((1-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)methyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocin-5-yl)carbamoyl)-1H-indol-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((S)-5-amino-1-(benzhydrylamino)-1,5-dioxopentan-2-yl)carbamoyl)-3-((1-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)methyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocin-5-yl)carbamoyl)-1H-indol-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((S)-5-amino-1-(benzhydrylamino)-1,5-dioxopentan-2-yl)carbamoyl)-3-((2-(2,6-dioxopiperidin-3-yl)-3-oxoisoindolin-5-yl)methyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocin-5-yl)carbamoyl)-1H-indol-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((S)-5-amino-1-(benzhydrylamino)-1,5-dioxopentan-2-yl)carbamoyl)-3-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-3-oxoisoindolin-5-yl)methyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocin-5-yl)carbamoyl)-1H-indol-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((S)-5-ammo-1-(benzhydrylammo)-1,5-dioxopentan-2-yl)carbamoyl)-3-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-3-oxoisoindolin-5-yl)methyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocin-5-yl)carbamoyl)-1H-indol-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((S)-5-amino-1-(benzhydrylamino)-1,5-dioxopentan-2-yl)carbamoyl)-3-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-3-oxoisoindolin-5-yl)methyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocin-5-yl)carbamoyl)-1H-indol-5-yl)difluoromethyl)phosphonic acid; 6-(1-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(1-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(1-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(1-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-(((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-(((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-(((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 3-(tert-butyl)-N-(4-(5-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)phenyl)-1H-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide; 3-(tert-butyl)-N-(4-(5-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)phenyl)-1H-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide; 3-(tert-butyl)-N-(4-(5-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)phenyl)-1H-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide; 3-(tert-butyl)-N-(4-(5-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)phenyl)-1H-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide; 3-(tert-butyl)-N-(4-(5-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)phenyl)-1H-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide; 3-(tert-butyl)-N-(4-(5-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)phenyl)-1H-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide; 3-(tert-butyl)-N-(4-(5-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)phenyl)-1H-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide; 3-(tert-butyl)-N-(4-(5-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)phenyl)-1H-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide; 3-(tert-butyl)-N-(4-(5-(4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)phenyl)-1H-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide; 3-(tert-butyl)-N-(4-(5-(4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)phenyl)-1H-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide; 3-(tert-butyl)-N-(4-(5-(4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)phenyl)-1H-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide; 3-(tert-butyl)-N-(4-(5-(4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)phenyl)-1H-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide; 3-(tert-butyl)-N-(4-(5-(4-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-1-yl)phenyl)-1H-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide; 3-(tert-butyl)-N-(4-(5-(4-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-1-yl)phenyl)-1H-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide; 3-(tert-butyl)-N-(4-(5-(4-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-1-yl)phenyl)-1H-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide; 3-(tert-butyl)-N-(4-(5-(4-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-1-yl)phenyl)-1H-indazol-3-yl)-2-methylbenzyl)-1,2,4-oxadiazole-5-carboxamide; 3-(5-((4-(6-((2'-(7,7-dimethyl-1-oxo-1,3,4,6,7,8-hexahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2-yl)-3'-(hydroxymethyl)-1-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridin]-5-yl)amino)pyridin-3-yl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(6-((2'-(7,7-dimethyl-1-oxo-1,3,4,6,7,8-hexahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2-yl)-3'-(hydroxymethyl)-1-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridin]-5-yl)amino)pyridin-3-yl)piperazin-1-yl)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(6-((2'-(7,7-dimethyl-1-oxo-1,3,4,6,7,8-hexahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2-yl)-3'-(hydroxymethyl)-1-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridin]-5-yl)amino)pyridin-3-yl)piperazin-1-yl)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(6-((2'-(7,7-dimethyl-1-oxo-1,3,4,6,7,8-hexahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2-yl)-3'-(hydroxymethyl)-1-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridin]-5-yl)amino)pyridin-3-yl)piperazin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((3-(4-(6-((2'-(7,7-dimethyl-1-oxo-1,3,4,6,7,8-hexahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2-yl)-3'-(hydroxymethyl)-1-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridin]-5-yl)amino)pyridin-3-yl)piperazin-1-yl)azetidin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((3-(4-(6-((2'-(7,7-dimethyl-1-oxo-1,3,4,6,7,8-hexahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2-yl)-3'-(hydroxymethyl)-1-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridin]-5-yl)amino)pyridin-3-yl)piperazin-1-yl)azetidin-1-yl)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((3-(4-(6-((2'-(7,7-dimethyl-1-oxo-1,3,4,6,7,8-hexahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2-yl)-3'-(hydroxymethyl)-1-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridin]-5-yl)amino)pyridin-3-yl)piperazin-1-yl)azetidin-1-yl)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((3-(4-(6-((2'-(7,7-dimethyl-1-oxo-1,3,4,6,7,8-hexahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2-yl)-3'-(hydroxymethyl)-1-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridin]-5-yl)amino)pyridin-3-yl)piperazin-1-yl)azetidin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(6-(((1-(6-((2'-(7,7-dimethyl-1-oxo-1,3,4,6,7,8-hexahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2-yl)-3'-(hydroxymethyl)-1-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridin]-5-yl)amino)pyridin-3-yl)piperidin-4-yl)(methyl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(6-(((1-(6-((2'-(7,7-dimethyl-1-oxo-1,3,4,6,7,8-hexahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2-yl)-3'-(hydroxymethyl)-1-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridin]-5-yl)amino)pyridin-3-yl)piperidin-4-yl)(methyl)amino)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(6-(((1-(6-((2'-(7,7-dimethyl-1-oxo-1,3,4,6,7,8-hexahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2-yl)-3'-(hydroxymethyl)-1-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridin]-5-yl)amino)pyridin-3-yl)piperidin-4-yl)(methyl)amino)methyl)-5-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(6-(((1-(6-((2'-(7,7-dimethyl-1-oxo-1,3,4,6,7,8-hexahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2-yl)-3'-(hydroxymethyl)-1-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridin]-5-yl)amino)pyridin-3-yl)piperidin-4-yl)(methyl)amino)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(1-(6-((2'-(7,7-dimethyl-1-oxo-1,3,4,6,7,8-hexahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2-yl)-3'-(hydroxymethyl)-1-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridin]-5-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(1-(6-((2'-(7,7-dimethyl-1-oxo-1,3,4,6,7,8-hexahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2-yl)-3'-(hydroxymethyl)-1-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridin]-5-yl)amino)pyridin-3 -yl)pip eridin-4-yl)pip erazin-1-yl)methyl)-4-fl uoro-1-oxoisoindolin-2-yl)pip eridine-2, 6-dione; 3-(5-((4-(1-(6-((2'-(7,7-dimethyl-1-oxo-1,3,4,6,7,8-hexahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2-yl)-3'-(hydroxymethyl)-1-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridin]-5-yl)amino)pyridin-3 -yl)piperidin-4-yl)piperazin-1 -yl)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(1-(6-((2'-(7,7-dimethyl-1-oxo-1,3,4,6,7,8-hexahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2-yl)-3'-(hydroxymethyl)-1-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridin]-5-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-(6-((2'-(7,7-dimethyl-1-oxo-1,3,4,6,7,8-hexahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2-yl)-3'-(hydroxymethyl)-1-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridin]-5-yl)amino)pyridin-3-yl)piperazin-1-yl)piperidin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-(6-((2'-(7,7-dimethyl-1-oxo-1,3,4,6,7,8-hexahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2-yl)-3'-(hydroxymethyl)-1-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridin]-5-yl)amino)pyridin-3-yl)piperazin-1-yl)piperidin-1-yl)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-(6-((2'-(7,7-dimethyl-1-oxo-1,3,4,6,7,8-hexahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2-yl)-3'-(hydroxymethyl)-1-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridin]-5-yl)amino)pyridin-3-yl)piperazin-1-yl)piperidin-1-yl)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-(6-((2'-(7,7-dimethyl-1-oxo-1,3,4,6,7,8-hexahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2-yl)-3'-(hydroxymethyl)-1-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridin]-5-yl)amino)pyridin-3-yl)piperazin-1-yl)piperidin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; (S)-3-(5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; (S)-3-(5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; (S)-3-(5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; (S)-3-(5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((3R,4S)-4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3-fluoropip eridin-1-yl)methyl)-1-oxoi soindolin-2-yl)pip eridine-2, 6-dione; 3-(5-(((3R,4S)-4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3-fluoropiperidin-1-yl)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((3R,4S)-4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3-fluoropiperidin-1-yl)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((3R,4S)-4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3-fluoropiperidin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((3S,4R)-4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3-fluoropiperidin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((3S,4R)-4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3-fluoropiperidin-1-yl)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((3S,4R)-4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3-fluoropiperidin-1-yl)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((3S,4R)-4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3-fluoropiperidin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((3R,4R)-4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3-fluoropiperidin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((3R,4R)-4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3-fluoropiperidin-1-yl)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((3R,4R)-4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3-fluoropiperidin-1-yl)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((3R,4R)-4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3-fluoropiperidin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((3S,4S)-4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3-fluoropiperidin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((3S,4S)-4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3-fluoropiperidin-1-yl)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((3S,4S)-4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3-fluoropiperidin-1-yl)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((3S,4S)-4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3-fluoropiperidin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3-fluoropiperidin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3-fluoropiperidin-1-yl)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3-fluoropiperidin-1-yl)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-3-fluoropiperidin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-(1,2-bis(4-hydroxyphenyl)but-1-en-1-yl)phenyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-(1,2-bis(4-hydroxyphenyl)but-1-en-1-yl)phenyl)piperazin-1-yl)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-(1,2-bis(4-hydroxyphenyl)but-1-en-1-yl)phenyl)piperazin-1-yl)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-(1,2-bis(4-hydroxyphenyl)but-1-en-1-yl)phenyl)piperazin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-(1-(4-hydroxyphenyl)-2-phenylbut-1-en-1-yl)phenyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-fluoro-5-((4-(4-(1-(4-hydroxyphenyl)-2-phenylbut-1-en-1-yl)phenyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(6-fluoro-5-((4-(4-(1-(4-hydroxyphenyl)-2-phenylbut-1-en-1-yl)phenyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(7-fluoro-5-((4-(4-(1-(4-hydroxyphenyl)-2-phenylbut-1-en-1-yl)phenyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-(4-chloro-1,2-bis(4-hydroxyphenyl)but-1-en-1-yl)phenyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-(4-chloro-1,2-bis(4-hydroxyphenyl)but-1-en-1-yl)phenyl)piperazin-1-yl)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3 -(5 -((4-(4-(4-chloro-1,2-bis(4-hydroxyphenyl)but-1 -en-1 -yl)phenyl)piperazin-1 -yl)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3 -(5 -((4-(4-(4-chloro-1,2-bis(4-hydroxyphenyl)but-1 -en-1 -yl)phenyl)piperazin-1 -yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-(4-chloro-1-(4-hydroxyphenyl)-2-phenylbut-1-en-1-yl)phenyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-(4-chloro-1-(4-hydroxyphenyl)-2-phenylbut-1-en-1-yl)phenyl)piperazin-1-yl)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-(4-chloro-1-(4-hydroxyphenyl)-2-phenylbut-1-en-1-yl)phenyl)piperazin-1-yl)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-(4-chloro-1-(4-hydroxyphenyl)-2-phenylbut-1-en-1-yl)phenyl)piperazin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((2-(4-(4-chloro-1,2-bis(4-hydroxyphenyl)but-1-en-1-yl)phenoxy)ethyl)(methyl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((2-(4-(4-chloro-1,2-bis(4-hydroxyphenyl)but-1-en-1-yl)phenoxy)ethyl)(methyl)amino)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((2-(4-(4-chloro-1,2-bis(4-hydroxyphenyl)but-1-en-1-yl)phenoxy)ethyl)(methyl)amino)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((2-(4-(4-chloro-1,2-bis(4-hydroxyphenyl)but-1-en-1-yl)phenoxy)ethyl)(methyl)amino)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((2-(4-(4-chloro-1,2-bis(4-hydroxyphenyl)but-1-en-1-yl)phenoxy)ethyl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((2-(4-(4-chloro-1,2-bis(4-hydroxyphenyl)but-1-en-1-yl)phenoxy)ethyl)amino)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((2-(4-(4-chloro-1,2-bis(4-hydroxyphenyl)but-1-en-1-yl)phenoxy)ethyl)amino)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((2-(4-(4-chloro-1,2-bis(4-hydroxyphenyl)but-1-en-1-yl)phenoxy)ethyl)amino)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-((1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-fluoro-5-((4-(4-((1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(6-fluoro-5-((4-(4-((1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(7-fluoro-5-((4-(4-((1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-((3S,4R)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-fluoro-5-((4-(4-((3S,4R)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(6-fluoro-5-((4-(4-((3S,4R)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(7-fluoro-5-((4-(4-((3S,4R)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((1-(4-((3S,4R)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperidin-4-yl)(methyl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-fluoro-5-(((1-(4-((3S,4R)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperidin-4-yl)(methyl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(6-fluoro-5-(((1-(4-((3S,4R)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperidin-4-yl)(methyl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(7-fluoro-5-(((1-(4-((3S,4R)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperidin-4-yl)(methyl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(1-(4-((3S,4R)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperidin-4-yl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-fluoro-5-((4-(1-(4-((3S,4R)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperidin-4-yl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(6-fluoro-5-((4-(1-(4-((3S,4R)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperidin-4-yl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(7-fluoro-5-((4-(1-(4-((3S,4R)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperidin-4-yl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((1-(4-((1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenyl)piperidin-4-yl)(methyl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-fluoro-5-(((1-(4-((1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenyl)piperidin-4-yl)(methyl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(6-fluoro-5-(((1-(4-((1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenyl)piperidin-4-yl)(methyl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(7-fluoro-5-(((1-(4-((1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenyl)piperidin-4-yl)(methyl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((2-(4-(1,2-bis(4-hydroxyphenyl)but-1-en-1-yl)phenoxy)ethyl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((2-(4-(1,2-bis(4-hydroxyphenyl)but-1-en-1-yl)phenoxy)ethyl)amino)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((2-(4-(1,2-bis(4-hydroxyphenyl)but-1-en-1-yl)phenoxy)ethyl)amino)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((2-(4-(1,2-bis(4-hydroxyphenyl)but-1-en-1-yl)phenoxy)ethyl)amino)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((2-(4-(1,2-bis(4-hydroxyphenyl)but-1-en-1-yl)phenoxy)ethyl)(methyl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((2-(4-(1,2-bis(4-hydroxyphenyl)but-1-en-1-yl)phenoxy)ethyl)(methyl)amino)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((2-(4-(1,2-bis(4-hydroxyphenyl)but-1-en-1-yl)phenoxy)ethyl)(methyl)amino)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((2-(4-(1,2-bis(4-hydroxyphenyl)but-1-en-1-yl)phenoxy)ethyl)(methyl)amino)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((2-(4-(1,2-diphenylbut-1-en-1-yl)phenoxy)ethyl)(methyl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((2-(4-(1,2-diphenylbut-1-en-1-yl)phenoxy)ethyl)(methyl)amino)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((2-(4-(1,2-diphenylbut-1-en-1-yl)phenoxy)ethyl)(methyl)amino)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((2-(4-(1,2-diphenylbut-1-en-1-yl)phenoxy)ethyl)(methyl)amino)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3 -(5 -(((2-(4-(4-chloro-1,2-diphenylbut-1 -en-1 -yl)phenoxy)ethyl)(methyl)amino)methyl)-1 - oxoisoindolin-2-yl)piperidine-2,6-dione; 3 -(5 -(((2-(4-(4-chloro-1,2-diphenylbut-1 -en-1 -yl)phenoxy)ethyl)(methyl)amino)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((2-(4-(4-chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethyl)(methyl)amino)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((2-(4-(4-chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethyl)(methyl)amino)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((1-(3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-4-methylpiperidin-4-yl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((1-(3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-4-methylpiperidin-4-yl)amino)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((1-(3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-4-methylpiperidin-4-yl)amino)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((1-(3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-4-methylpiperidin-4-yl)amino)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(3-(6-(4-amino-4-methylpiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl)-2-chlorophenyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(3-(6-(4-amino-4-methylpiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl)-2-chlorophenyl)piperazin-1-yl)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(3-(6-(4-amino-4-methylpiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl)-2-chlorophenyl)piperazin-1-yl)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(3-(6-(4-amino-4-methylpiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl)-2-chlorophenyl)piperazin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(3-((3-amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(3-((3-amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)piperazin-1-yl)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(3-((3-amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)piperazin-1-yl)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(3-((3-amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)piperazin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((3-((3-amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)amino)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((3-((3-amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)amino)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((3-((3-amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)amino)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((3-((3-amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(3-(3-amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)-2-chlorophenyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(3-(3-amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)-2-chlorophenyl)piperazin-1-yl)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(3-(3-amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)-2-chlorophenyl)piperazin-1-yl)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(3-(3-amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)-2-chlorophenyl)piperazin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((((3S,4S)-8-(6-amino-5-((2-amino-3-chloropyridin-4-yl)thio)pyrazin-2-yl)-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-yl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((((3S,4S)-8-(6-amino-5-((2-amino-3-chloropyridin-4-yl)thio)pyrazin-2-yl)-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-yl)amino)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((((3S,4S)-8-(6-amino-5-((2-amino-3-chloropyridin-4-yl)thio)pyrazin-2-yl)-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-yl)amino)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((((3S,4S)-8-(6-amino-5-((2-amino-3-chloropyridin-4-yl)thio)pyrazin-2-yl)-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-yl)amino)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((((3S,4S)-8-(6-amino-5-((2-aminopyridin-4-yl)thio)pyrazin-2-yl)-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-yl)amino)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((((3S,4S)-8-(6-amino-5-((2-aminopyridin-4-yl)thio)pyrazin-2-yl)-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-yl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((((3S,4S)-8-(6-amino-5-((2-aminopyridin-4-yl)thio)pyrazin-2-yl)-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-yl)amino)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((((3S,4S)-8-(6-amino-5-((2-aminopyridin-4-yl)thio)pyrazin-2-yl)-3-methyl-2-oxa-8-azaspiro[4.5]decan-4-yl)amino)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-((3-amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)pyridin-2-yl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-((3-amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)pyridin-2-yl)pip erazin-1-yl)methyl)-4-fl uoro-1-oxoisoindolin-2-yl)pip eridine-2, 6-dione; 3-(5-((4-(4-((3-amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)pyridin-2-yl)pip erazin-1-yl)methyl)-6-fl uoro-1-oxoisoindolin-2-yl)pip eridine-2, 6-dione; 3-(5-((4-(4-((3-amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)pyridin-2-yl)pip erazin-1-yl)methyl)-7-fl uoro-1-oxoisoindolin-2-yl)pip eridine-2, 6-dione; 3-(5-((4-(4-((3-amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)-3-chloropyridin-2-yl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-((3-amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)-3-chloropyridin-2-yl)piperazin-1-yl)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-((3-amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)-3-chloropyridin-2-yl)piperazin-1-yl)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-((3-amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)-3-chloropyridin-2-yl)piperazin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((1-(6-amino-5-(2,3-dichlorophenyl)pyrazin-2-yl)-4-methylpiperidin-4-yl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((1-(6-amino-5-(2,3-dichlorophenyl)pyrazin-2-yl)-4-methylpiperidin-4-yl)amino)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((1-(6-amino-5-(2,3-dichlorophenyl)pyrazin-2-yl)-4-methylpiperidin-4-yl)amino)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((1-(6-amino-5-(2,3-dichlorophenyl)pyrazin-2-yl)-4-methylpiperidin-4-yl)amino)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((2,3-difluoro-6-(2-morpholinothiazol-4-yl)phenoxy)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((2,3-difluoro-6-(2-morpholinothiazol-4-yl)phenoxy)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((2,3-difluoro-6-(2-morpholinothiazol-4-yl)phenoxy)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((2,3-difluoro-6-(2-morpholinothiazol-4-yl)phenoxy)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)pyridazine-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)pyridazine-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)pyridazine-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)pyridazine-3-carboxamide; N-((1r,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)pyridazine-3-carboxamide; N-((1r,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)pyridazine-3-carboxamide; N-((1r,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)pyridazine-3-carboxamide; N-((1r,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)pyridazine-3-carboxamide; N-((1r,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)nicotinamide; N-((1r,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((2-(2,6-dioxopip eridin-3 -yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)pip erazin-1-yl)ni cotinami de; N-((1r,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((2-(2,6-dioxopip eridin-3 -yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)pip erazin-1-yl)ni cotinami de; N-((1r,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((2-(2,6-dioxopip eridin-3 -yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)pip erazin-1-yl)ni cotinami de; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(8-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)pyridazine-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(8-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)pyridazine-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(8-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)pyridazine-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(8-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)pyridazine-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(6-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-3,6-di azabi cyclo[3.1.1]heptan-3-yl)pyridazine-3-carboxami de; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(6-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridazine-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(6-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridazine-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(6-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridazine-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(3-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-3,6-di azabi cyclo[3.1.1]heptan-6-yl)pyridazine-3-carboxami de; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(3-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-6-yl)pyridazine-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(3-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-6-yl)pyridazine-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(3-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-6-yl)pyridazine-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(3-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-3,8-diazabicyclo[3.2.1]octan-8-yl)pyridazine-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(3-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)-3,8-diazabicyclo[3.2.1]octan-8-yl)pyridazine-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(3-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)-3,8-diazabicyclo[3.2.1]octan-8-yl)pyridazine-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(3-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)-3,8-diazabicyclo[3.2.1]octan-8-yl)pyridazine-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)pyridazine-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)pyridazine-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)pyridazine-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)pyridazine-3-carboxamide; 3-(5-((4-(4-((9-cyclopentyl-8-(phenylamino)-9H-purin-2-yl)amino)phenyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-((9-cyclopentyl-8-(phenylamino)-9H-purin-2-yl)amino)phenyl)piperazin-1-yl)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-((9-cyclopentyl-8-(phenylamino)-9H-purin-2-yl)amino)phenyl)piperazin-1-yl)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-((9-cyclopentyl-8-(phenylamino)-9H-purin-2-yl)amino)phenyl)piperazin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((1-(4-((9-cyclopentyl-8-(phenylamino)-9H-purin-2-yl)amino)phenyl)piperidin-4-yl)(methyl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((1-(4-((9-cyclopentyl-8-(phenylamino)-9H-purin-2-yl)amino)phenyl)piperidin-4-yl)(methyl)amino)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((1-(4-((9-cyclopentyl-8-(phenylamino)-9H-purin-2-yl)amino)phenyl)piperidin-4-yl)(methyl)amino)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((1-(4-((9-cyclopentyl-8-(phenylamino)-9H-purin-2-yl)amino)phenyl)piperidin-4-yl)(methyl)amino)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(1-(4-((9-cyclopentyl-8-(phenylamino)-9H-purin-2-yl)amino)phenyl)piperidin-4-yl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(1-(4-((9-cyclopentyl-8-(phenylamino)-9H-purin-2-yl)amino)phenyl)piperidin-4-yl)piperazin-1-yl)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(1-(4-((9-cyclopentyl-8-(phenylamino)-9H-purin-2-yl)amino)phenyl)piperidin-4-yl)piperazin-1-yl)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(1-(4-((9-cyclopentyl-8-(phenylamino)-9H-purin-2-yl)amino)phenyl)piperidin-4-yl)piperazin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-(4-((9-cyclopentyl-8-(phenylamino)-9H-purin-2-yl)amino)phenyl)piperazin-1-yl)piperidin-1 -yl)methyl)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-(4-((9-cyclopentyl-8-(phenylamino)-9H-purin-2-yl)amino)phenyl)piperazin-1-yl)piperidin-1-yl)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-(4-((9-cyclopentyl-8-(phenylamino)-9H-purin-2-yl)amino)phenyl)piperazin-1-yl)pip eridin-1-yl)methyl)-6-fl uoro-1-oxoisoindolin-2-yl)pip eri dine-2, 6-dione; 3-(5-((4-(4-(4-((9-cyclopentyl-8-(phenylamino)-9H-purin-2-yl)amino)phenyl)piperazin-1-yl)piperidin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((5-methoxy-4-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-nitrophenyl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-fluoro-5-(((5-methoxy-4-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-nitrophenyl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(6-fluoro-5-(((5-methoxy-4-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-nitrophenyl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(7-fluoro-5-(((5-methoxy-4-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-nitrophenyl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; N-(2-((2-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)(methyl)amino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide; N-(2-((2-(((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide; N-(2-((2-(((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide; N-(2-((2-(((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide; 3-(5-((4-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1-yl)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1-yl)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)propoxy)quinazolin-6-yl)acrylamide; N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)propoxy)quinazolin-6-yl)acrylamide; N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)propoxy)quinazolin-6-yl)acrylamide; N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)propoxy)quinazolin-6-yl)acrylamide; 3-(5-(((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1-yl)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1-yl)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)amino)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)amino)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)amino)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)amino)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)amino)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)amino)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; (E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)but-2-enamide; (E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)but-2-enamide; (E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)but-2-enamide; (E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)but-2-enamide; 2-(7-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)amino)-1-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide; 2-(7-(((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)amino)-1-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide; 2-(7-(((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)amino)-1-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide; 2-(7-(((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)amino)-1-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide; 2-(6-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)-1-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide; 2-(6-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)-1-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide; 2-(6-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)-1-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide; 2-(6-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)-1-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide; 2-(6-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)-1-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide; 2-(6-(4-(((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)-1-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide; 2-(6-(4-(((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)-1-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide; 2-(6-(4-(((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)-1-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide; 2-(6-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)-1-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide; 2-(6-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)-1-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide; 2-(6-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)-1-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide; 2-(6-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)-1-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide; 2-(6-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)phenyl)-1-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide; 2-(6-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)phenyl)-1-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide; 2-(6-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)phenyl)-1-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide; 2-(6-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)phenyl)-1-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide; 2-(6-(6-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)pyridazin-3-yl)-1-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide; 2-(6-(6-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)pyridazin-3-yl)-1-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide; 2-(6-(6-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)pyridazin-3-yl)-1-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide; 2-(6-(6-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)pyridazin-3-yl)-1-oxoisoindolin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazol-2-yl)acetamide; 3-(1-oxo-5-((4-(((R,E)-11,26,7-trimethyl-3-oxo-52,53-dihydro-11H,51H-11-oxa-4-aza-5(2,1)-benzo[d]imidazola-2(2,4)-pyridina-1(4,5)-pyrazolacycloundecaphane-56-yl)methyl)piperazin-1-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione; 3-(4-fluoro-1-oxo-5-((4-(((R,E)-11,26,7-trimethyl-3-oxo-52,53-dihydro-11H,51H-11-oxa-4-aza-5(2,1)-benzo[d]imidazola-2(2,4)-pyridina-1(4,5)-pyrazolacycloundecaphane-56-yl)methyl)piperazin-1-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione; 3-(7-fluoro-1-oxo-5-((4-(((R,E)-11,26,7-trimethyl-3-oxo-52,53-dihydro-11H,51H-11-oxa-4-aza-5(2,1)-benzo[d]imidazola-2(2,4)-pyridina-1(4,5)-pyrazolacycloundecaphane-56-yl)methyl)piperazin-1-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione; 3-(6-fluoro-1-oxo-5-((4-(((R,E)-11,26,7-trimethyl-3-oxo-52,53-dihydro-11H,51H-11-oxa-4-aza-5(2,1)-benzo[d]imidazola-2(2,4)-pyridina-1(4,5)-pyrazolacycloundecaphane-56-yl)methyl)piperazin-1-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione; 3-(1-oxo-5-((4-((R,E)-11,26,7-trimethyl-3-oxo-52,53-dihydro-11H,51H-11-oxa-4-aza-5(2,1)-benzo[d]imidazola-2(2,4)-pyridina-1(4,5)-pyrazolacycloundecaphane-56-yl)piperazin-1-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione; 3-(4-fluoro-1-oxo-5-((4-((R,E)-11,26,7-trimethyl-3-oxo-52,53-dihydro-11H,51H-11-oxa-4-aza-5(2,1)-benzo[d]imidazola-2(2,4)-pyridina-1(4,5)-pyrazolacycloundecaphane-56-yl)piperazin-1-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione; 3-(6-fluoro-1-oxo-5-((4-((R,E)-11,26,7-trimethyl-3-oxo-52,53-dihydro-11H,51H-11-oxa-4-aza-5(2,1)-benzo[d]imidazola-2(2,4)-pyridina-1(4,5)-pyrazolacycloundecaphane-56-yl)piperazin-1-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione; 3-(7-fluoro-1-oxo-5-((4-((R,E)-11,26,7-trimethyl-3-oxo-52,53-dihydro-11H,51H-11-oxa-4-aza-5(2,1)-benzo[d]imidazola-2(2,4)-pyridina-1(4,5)-pyrazolacycloundecaphane-56-yl)piperazin-1-yl)methyl)isoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(6-((2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1-isopropyl-1H-pyrazolo[4,3-c]pyridin-3-yl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(6-((2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1-isopropyl-1H-pyrazolo[4,3-c]pyridin-3-yl)piperazin-1-yl)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(6-((2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1-isopropyl-1H-pyrazolo[4,3-c]pyridin-3-yl)piperazin-1-yl)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(6-((2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1-isopropyl-1H-pyrazolo[4,3-c]pyridin-3-yl)piperazin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((1-(6-((2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1-isopropyl-1H-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)(methyl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((1-(6-((2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1-isopropyl-1H-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)(methyl)amino)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((1-(6-((2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1-isopropyl-1H-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)(methyl)amino)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((1-(6-((2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1-isopropyl-1H-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)(methyl)amino)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(1-(6-((2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1-isopropyl-1H-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(1-(6-((2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1-isopropyl-1H-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(1-(6-((2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1-isopropyl-1H-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(1-(6-((2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1-isopropyl-1H-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-(6-((2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1-isopropyl-1H-pyrazolo[4,3-c]pyridin-3-yl)piperazin-1-yl)piperidin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-(6-((2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1-isopropyl-1H-pyrazolo[4,3-c]pyridin-3-yl)piperazin-1-yl)piperidin-1-yl)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-(6-((2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1-isopropyl-1H-pyrazolo[4,3-c]pyridin-3-yl)piperazin-1-yl)piperidin-1-yl)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-(6-((2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)amino)-1-isopropyl-1H-pyrazolo[4,3-c]pyridin-3-yl)piperazin-1-yl)piperidin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(1-isopropyl-6-((2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-1H-pyrazolo[4,3-c]pyridin-3-yl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-fluoro-5-((4-(1-isopropyl-6-((2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-1H-pyrazolo[4,3-c]pyridin-3-yl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(6-fluoro-5-((4-(1-isopropyl-6-((2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-1H-pyrazolo[4,3-c]pyridin-3-yl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(7-fluoro-5-((4-(1-isopropyl-6-((2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-1H-pyrazolo[4,3-c]pyridin-3-yl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((1-(1-isopropyl-6-((2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-1H-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)(methyl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-fluoro-5-(((1-(1-isopropyl-6-((2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-1H-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)(methyl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(6-fluoro-5-(((1-(1-isopropyl-6-((2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-1H-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)(methyl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(7-fluoro-5-(((1-(1-isopropyl-6-((2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-1H-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)(methyl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(1-(1-isopropyl-6-((2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-1H-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-fluoro-5-((4-(1-(1-isopropyl-6-((2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-1H-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(6-fluoro-5-((4-(1-(1-isopropyl-6-((2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-1H-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(7-fluoro-5-((4-(1-(1-isopropyl-6-((2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-1H-pyrazolo[4,3-c]pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-(1-isopropyl-6-((2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-1H-pyrazolo[4,3-c]pyridin-3-yl)piperazin-1-yl)piperidin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-fluoro-5-((4-(4-(1-isopropyl-6-((2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-1H-pyrazolo[4,3-c]pyridin-3-yl)piperazin-1-yl)piperidin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(6-fluoro-5-((4-(4-(1-isopropyl-6-((2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-1H-pyrazolo[4,3-c]pyridin-3-yl)piperazin-1-yl)piperidin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(7-fluoro-5-((4-(4-(1-isopropyl-6-((2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl)amino)-1H-pyrazolo[4,3-c]pyridin-3-yl)piperazin-1-yl)piperidin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-1-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperidine-4-carboxamide; N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-1-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperidine-4-carboxamide; N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-1-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperidine-4-carboxamide; N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-1-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperidine-4-carboxamide; N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-1'-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-[1,4'-bipiperidine]-4-carboxamide; N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-1'-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)-[1,4'-bipiperidine]-4-carboxamide; N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-1'-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)-[1,4'-bipiperidine]-4-carboxamide; N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-1'-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)-[1,4'-bipiperidine]-4-carboxamide; N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-4-(1-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazine-1-carboxamide; N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-4-(1-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazine-1-carboxamide; N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-4-(1-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazine-1-carboxamide; N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-4-(1-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazine-1-carboxamide; 4-(2,6-dichlorobenzamido)-N-(1-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)-1H-pyrazole-3-carboxamide; 4-(2,6-dichlorobenzamido)-N-(1-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)-1H-pyrazole-3-carboxamide; 4-(2,6-dichlorobenzamido)-N-(1-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)-1H-pyrazole-3-carboxamide; 4-(2,6-dichlorobenzamido)-N-(1-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)-1H-pyrazole-3-carboxamide; N-(5-chloro-4-(5,5-dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)pyridin-2-yl)-1-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperidine-4-carboxamide; N-(5-chloro-4-(5,5-dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)pyridin-2-yl)-1-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperidine-4-carboxamide; N-(5-chloro-4-(5,5-dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)pyridin-2-yl)-1-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperidine-4-carboxamide; N-(5-chloro-4-(5,5-dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)pyridin-2-yl)-1-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperidine-4-carboxamide; N-(5-cyclobutyl-1H-pyrazol-3-yl)-2-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methoxy)phenyl)acetamide; N-(5-cyclobutyl-1H-pyrazol-3-yl)-2-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methoxy)phenyl)acetamide; N-(5-cyclobutyl-1H-pyrazol-3-yl)-2-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methoxy)phenyl)acetamide; N-(5-cyclobutyl-1H-pyrazol-3-yl)-2-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methoxy)phenyl)acetamide; 3-(5-((4-((5-chloro-4-(5-(cyclopropylmethyl)-1-methyl-1H-pyrazol-4-yl)pyrimidin-2-yl)amino)piperidin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-((5-chloro-4-(5-(cyclopropylmethyl)-1-methyl-1H-pyrazol-4-yl)pyrimidin-2-yl)amino)piperidin-1-yl)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-((5-chloro-4-(5-(cyclopropylmethyl)-1-methyl-1H-pyrazol-4-yl)pyrimidin-2-yl)amino)piperidin-1-yl)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-((5-chloro-4-(5-(cyclopropylmethyl)-1-methyl-1H-pyrazol-4-yl)pyrimidin-2-yl)amino)piperidin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-N-(4-(((5-(((S)-1-hydroxybutan-2-yl)amino)-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)amino)methyl)phenyl)piperazine-1-carboxamide; 4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)-N-(4-(((5-(((S)-1-hydroxybutan-2-yl)amino)-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)amino)methyl)phenyl)piperazine-1 -carboxamide; 4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)-N-(4-(((5-(((S)-1-hydroxybutan-2-yl)amino)-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)amino)methyl)phenyl)piperazine-1 -carboxamide; 4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)-N-(4-(((5-(((S)-1-hydroxybutan-2-yl)amino)-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)amino)methyl)phenyl)piperazine-1 -carboxamide; 4-(((4-(5-chloro-2-((1-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile; 4-(((4-(5-chloro-2-((1-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile; 4-(((4-(5-chloro-2-((1-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile; 4-(((4-(5-chloro-2-((1-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile; 4-(((5'-chloro-2'-((1-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)amino)-[2,4'-bipyridin]-6-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile; 4-(((5'-chloro-2'-((1-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)amino)-[2,4'-bipyridin]-6-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile; 4-(((5'-chloro-2'-((1-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)amino)-[2,4'-bipyridin]-6-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile; 4-(((5'-chloro-2'-((1-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)amino)-[2,4'-bipyridin]-6-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile; 3-((4-(2-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)(methyl)amino)-4-methylthiazol-5-yl)-5-fluoropyrimidin-2-yl)amino)benzenesulfonamide; 3-((4-(2-(((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)-4-methylthiazol-5-yl)-5-fluoropyrimidin-2-yl)amino)benzenesulfonamide; 3-((4-(2-(((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)-4-methylthiazol-5-yl)-5-fluoropyrimidin-2-yl)amino)benzenesulfonamide; 3-((4-(2-(((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)-4-methylthiazol-5-yl)-5-fluoropyrimidin-2-yl)amino)benzenesulfonamide; N-(2-chloro-6-methylphenyl)-2-((6-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)amino)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide; N-(2-chloro-6-methylphenyl)-2-((6-(((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)amino)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide; N-(2-chloro-6-methylphenyl)-2-((6-(((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)amino)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide; N-(2-chloro-6-methylphenyl)-2-((6-(((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)amino)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide; N-(2-chloro-6-methylphenyl)-2-((6-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide; N-(2-chloro-6-methylphenyl)-2-((6-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide; N-(2-chloro-6-methylphenyl)-2-((6-(4-((2-(2, 6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide; N-(2-chloro-6-methylphenyl)-2-((6-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide; N-(2-chloro-6-methylphenyl)-2-((6-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide; N-(2-chloro-6-methylphenyl)-2-((6-(4-(((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide; N-(2-chloro-6-methylphenyl)-2-((6-(4-(((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide; N-(2-chloro-6-methylphenyl)-2-((6-(4-(((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide; N-(2-chloro-6-methylphenyl)-2-((6-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide; N-(2-chloro-6-methylphenyl)-2-((6-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide; N-(2-chloro-6-methylphenyl)-2-((6-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide; N-(2-chloro-6-methylphenyl)-2-((6-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide; 4-((4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide; 4-((4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide; 4-((4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide; 4-((4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide; 4-((((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)amino)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide; 4-((((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)amino)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide; 4-((((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)amino)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide; 4-((((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)amino)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide; 4-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide; 4-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide; 4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide; 4-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide; 4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide; 4-(4-(((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide; 4-(4-(((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide; 4-(4-(((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide; 4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide; 4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide; 4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide; 4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide; 4-((2,4-dichloro-5-methoxyphenyl)amino)-7-(3-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)propoxy)-6-methoxyquinoline-3-carbonitrile; 4-((2,4-dichloro-5-methoxyphenyl)amino)-7-(3-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)propoxy)-6-methoxyquinoline-3-carbonitrile; 4-((2,4-dichloro-5-methoxyphenyl)amino)-7-(3-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)propoxy)-6-methoxyquinoline-3-carbonitrile; 4-((2,4-dichloro-5-methoxyphenyl)amino)-7-(3-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)propoxy)-6-methoxyquinoline-3-carbonitrile; 4-((2,4-dichloro-5-methoxyphenyl)amino)-7-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methoxy)-6-methoxyquinoline-3-carbonitrile; 4-((2,4-dichloro-5-methoxyphenyl)amino)-7-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methoxy)-6-methoxyquinoline-3-carbonitrile; 4-((2,4-dichloro-5-methoxyphenyl)amino)-7-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methoxy)-6-methoxyquinoline-3-carbonitrile; 4-((2,4-dichloro-5-methoxyphenyl)amino)-7-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methoxy)-6-methoxyquinoline-3-carbonitrile; N-(4-((4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzamide; N-(4-((4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzamide; N-(4-((4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzamide; N-(4-((4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzamide; N-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)-3-(trifluoromethyl)phenyl)-3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzamide; N-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)-3-(trifluoromethyl)phenyl)-3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzamide; N-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)-3-(trifluoromethyl)phenyl)-3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzamide; N-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)-3-(trifluoromethyl)phenyl)-3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzamide; N-(4-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-1-yl)-3-(trifluoromethyl)phenyl)-3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzamide; N-(4-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-1-yl)-3-(trifluoromethyl)phenyl)-3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzamide; N-(4-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-1-yl)-3-(trifluoromethyl)phenyl)-3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzamide; N-(4-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-1-yl)-3-(trifluoromethyl)phenyl)-3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzamide; N-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)-3-(trifluoromethyl)phenyl)-3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzamide; N-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)-3-(trifluoromethyl)phenyl)-3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzamide; N-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)-3-(trifluoromethyl)phenyl)-3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzamide; N-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)-3-(trifluoromethyl)phenyl)-3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzamide; 2-(4-((3 S)-1-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide; 2-(4-((3S)-1-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide; 2-(4-((3 S)-1-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide; 2-(4-((3 S)-1-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide; 2-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)phenyl)-2H-indazole-7-carboxamide; 2-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)phenyl)-2H-indazole-7-carboxamide; 2-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)phenyl)-2H-indazole-7-carboxamide; 2-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)phenyl)-2H-indazole-7-carboxamide; 2-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)phenyl)-2H-indazole-7-carboxamide; 2-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)phenyl)-2H-indazole-7-carboxamide; 2-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)phenyl)-2H-indazole-7-carboxamide; 2-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)phenyl)-2H-indazole-7-carboxamide; 3-(5-((4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-fluoro-5-((4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(6-fluoro-5-((4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(7-fluoro-5-((4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((4-(8-fluoro-1-oxo-2,3,4,6-tetrahydro-1H-azepino[5,4,3-cd]indol-5-yl)benzyl)(methyl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-fluoro-5-(((4-(8-fluoro-1-oxo-2,3,4,6-tetrahydro-1H-azepino[5,4,3-cd]indol-5-yl)benzyl)(methyl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(6-fluoro-5-(((4-(8-fluoro-1-oxo-2,3,4,6-tetrahydro-1H-azepino[5,4,3-cd]indol-5-yl)benzyl)(methyl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(7-fluoro-5-(((4-(8-fluoro-1-oxo-2,3,4,6-tetrahydro-1H-azepino[5,4,3-cd]indol-5-yl)benzyl)(methyl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(2-fluoro-5-((8S,9R)-5-fluoro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-3-oxo-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-8-yl)phenyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-fluoro-5-((4-(2-fluoro-5-((8S,9R)-5-fluoro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-3-oxo-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-8-yl)phenyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(6-fluoro-5-((4-(2-fluoro-5-((8S,9R)-5-fluoro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-3-oxo-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-8-yl)phenyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(7-fluoro-5-((4-(2-fluoro-5-((8S,9R)-5-fluoro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-3-oxo-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-8-yl)phenyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-((2-fluoro-5-((8S,9R)-5-fluoro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-3-oxo-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-8-yl)phenyl)ethynyl)piperidin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-fluoro-5-((4-((2-fluoro-5-((8S,9R)-5-fluoro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-3-oxo-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-8-yl)phenyl)ethynyl)piperidin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(6-fluoro-5-((4-((2-fluoro-5-((8S,9R)-5-fluoro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-3-oxo-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-8-yl)phenyl)ethynyl)piperidin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(7-fluoro-5-((4-((2-fluoro-5-((8S,9R)-5-fluoro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-3-oxo-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-8-yl)phenyl)ethynyl)piperidin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 7-cyclopentyl-2-((5-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide; 7-cyclopentyl-2-((5-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide; 7-cyclopentyl-2-((5-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide; 7-cyclopentyl-2-((5-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide; 7-cyclopentyl-2-((5-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide; 7-cyclopentyl-2-((5-(4-(((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide; 7-cyclopentyl-2-((5-(4-(((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide; 7-cyclopentyl-2-((5-(4-(((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide; 7-cyclopentyl-2-((5-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide; 7-cyclopentyl-2-((5-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)pyridin-2-yl)amino)- N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide; 7-cyclopentyl-2-((5-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)pyridin-2-yl)amino)- N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide; 7-cyclopentyl-2-((5-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)pyridin-2-yl)amino)- N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide; 7-cyclopentyl-2-((5-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide; 7-cyclopentyl-2-((5-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide; 7-cyclopentyl-2-((5-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide; 7-cyclopentyl-2-((5-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide; 3-(5-((4-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyri din-3 -yl)methyl)piperazin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-fluoro-5-((4-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(6-fluoro-5-((4-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(7-fluoro-5-((4-((6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(difluoro(6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(difluoro(6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperazin-1-yl)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(difluoro(6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperazin-1-yl)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(difluoro(6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperazin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-fluoro-5-((4-(6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(6-fluoro-5-((4-(6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(7-fluoro-5-((4-(6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((1-(6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)(methyl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-fluoro-5-(((1-(6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)(methyl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(6-fluoro-5-(((1-(6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)(methyl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(7-fluoro-5-(((1-(6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)(methyl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(1-(6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-fluoro-5-((4-(1-(6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(6-fluoro-5-((4-(1-(6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(7-fluoro-5-((4-(1-(6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-(6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)piperidin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(4-fluoro-5-((4-(4-(6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)piperidin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(6-fluoro-5-((4-(4-(6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)piperidin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(7-fluoro-5-((4-(4-(6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)piperidin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(difluoro(6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(difluoro(6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperazin-1-yl)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(difluoro(6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperazin-1-yl)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(difluoro(6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)pyridin-3-yl)methyl)piperazin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)(methyl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)(methyl)amino)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)(methyl)amino)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)(methyl)amino)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperidin-4-yl)piperazin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)piperidin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)piperidin-1-yl)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)piperidin-1-yl)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)piperidin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)-3-methoxyphenyl)amino)-6-ethyl-5-((tetrahydro-2H-pyran-4-yl)amino)pyrazine-2-carboxamide; 3-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)-3-methoxyphenyl)amino)-6-ethyl-5-((tetrahydro-2H-pyran-4-yl)amino)pyrazine-2-carboxamide; 3-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)-3-methoxyphenyl)amino)-6-ethyl-5-((tetrahydro-2H-pyran-4-yl)amino)pyrazine-2-carboxamide; 3-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)-3-methoxyphenyl)amino)-6-ethyl-5-((tetrahydro-2H-pyran-4-yl)amino)pyrazine-2-carboxamide; 3-(5-(((1-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)(methyl)amino)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione,' 3-(5-(((1-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)(methyl)amino)methyl)-4-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((1-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)(methyl)amino)methyl)-6-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((1-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)(methyl)amino)methyl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((1-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((1-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)amino)methyl)-4-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione,' 3-(5-(((1-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)amino)methyl)-6-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione,' 3-(5-(((1-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)amino)methyl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione,' 3-(5-((4-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione,' 3-(5-((4-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1-yl)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione ; 3-(5-((4-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-l-yl)methyl)-6-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione,' 3-(5-((4-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1-yl)piperidin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1 -yl)piperidin-1 -yl)methyl)-4-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1 -yl)piperidin-1 -yl)methyl)-6-fluoro-1 -oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1-yl)piperidin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-(6-amino-5-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)piperidin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione ; 3-(5-((4-(4-(6-amino-5-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)piperidin-1-yl)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-(6-amino-5-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)piperidin-1-yl)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione ; 3-(5-((4-(4-(6-amino-5-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)piperidin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione ; 3-(5-((4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione ; 3-(5-((4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-1-yl)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-1-yl)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione ; 3-(5-((4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperazin-l-yl)methyl)-4-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperazin-l-yl)methyl)-6-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperazin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((1-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)(methyl)amino)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((1-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)(methyl)amino)methyl)-4-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((1-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)(methyl)amino)methyl)-6-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((1-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)(methyl)amino)methyl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(1-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)piperazin-l-yl)methyl)-l-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(1-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)piperazin-l-yl)methyl)-4-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(1-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)piperazin-l-yl)methyl)-6-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(1-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-4-yl)piperazin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 8-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile; 8-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile; 8-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile; 8-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile; 8-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-SH-benzo[b]carbazole-3-carbonitrile; 8-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile; 8-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile; 8-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile; 8-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile; 8-(4-(((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile; 8-(4-(((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile; 8-(4-(((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile; 3-(5-((4-(1-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(1-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)piperazin-l-yl)methyl)-4-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(1-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)piperazin-l-yl)methyl)-6-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(1-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)piperazin-l-yl)methyl)-7-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione; (4R)-26-amino-11-(1-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)-55-fluoro-4,7-dimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile; (4R)-26-amino-11-(1-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)-55-fluoro-4,7-dimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile; (4R)-26-amino-11-(1-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)-55-fluoro-4,7-dimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile; (4R)-26-amino-11-(1-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)-55-fluoro-4,7-dimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile; 2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)acetamide; 2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)acetamide; 2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)acetamide; 2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)acetamide; 2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(2-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)ethyl)acetamide ; 2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(2-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)ethyl)acetamide; 2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(2-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)ethyl)acetamide; 2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(2-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)ethyl)acetamide; 3-(5-((4-(2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetyl)piperazin-1-yl)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetyl)piperazin-1-yl)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetyl)piperazin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)ethyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)ethyl)piperazin-1-yl)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione ; 3-(5-((4-(2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)ethyl)piperazin-1-yl)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione ; 3-(5-((4-(2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)ethyl)piperazin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione ; 3-(6-((4-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(6-((4-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)piperazin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(6-((4-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)piperazin-1-yl)methyl)-5-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(6-((4-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)piperazin-1-yl)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((1-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)piperidin-4-yl)(methyl)amino)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((1-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)piperidin-4-yl)(methyl)amino)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((1-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)piperidin-4-yl)(methyl)amino)methyl)-6-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-(((1-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)piperidin-4-yl)(methyl)amino)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(1-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)piperidin-4-yl)piperazin-1-yl)methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(5-((4-(1-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)piperidin-4-yl)piperazin-1-yl)methyl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione ; 3-(5-((4-(1-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)piperidin-4-yl)piperazin-l-yl)methyl)-6-fluoro-l-oxoisoindolin-2-yl)piperidine-2,6-dione,' 3-(5-((4-(1-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)piperidin-4-yl)piperazin-1-yl)methyl)-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 4-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)-N-(5-((R)-2-methoxy-2-phenylacetyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)benzamide; 4-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)-N-(5-((R)-2-methoxy-2-phenylacetyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)benzamide; 4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)-N-(5-((R)-2-methoxy-2-phenylacetyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)benzamide; 4-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)-N-(5-((R)-2-methoxy-2-phenylacetyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)benzamide; 4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)-N-(5-((R)-2-methoxy-2-phenylacetyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)benzamide; 4-(4-(((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)-N-(5-((R)-2-methoxy-2-phenylacetyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)benzamide; 4-(4-(((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-l-yl)-N-(5-((R)-2-methoxy-2-phenylacetyl)-l,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)benzamide; 4-(4-(((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-l-yl)-N-(5-((R)-2-methoxy-2-phenylacetyl)-l,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)benzamide; 4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)-N-(5-((R)-2-methoxy-2-phenylacetyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)benzamide; 4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-l-yl)-N-(5-((R)-2-methoxy-2-phenylacetyl)-l,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)benzamide; 4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-l-yl)-N-(5-((R)-2-methoxy-2-phenylacetyl)-l,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)benzamide; 4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-l-yl)-N-(5-((R)-2-methoxy-2-phenylacetyl)-l,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)benzamide; N-(tert-butyl)-3-((2-((6-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)pyridazin-3-yl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide; N-(tert-butyl)-3-((2-((6-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)pyridazin-3-yl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide; N-(tert-butyl)-3-((2-((6-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)pyridazin-3-yl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide; N-(tert-butyl)-3-((2-((6-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)pyridazin-3-yl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide; N-(tert-butyl)-3-((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide; N-(tert-butyl)-3-((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide; N-(tert-butyl)-3-((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide; N-(tert-butyl)-3-((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide; N-(tert-butyl)-3-((2-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide; N-(tert-butyl)-3-((2-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide; N-(tert-butyl)-3-((2-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxolsoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide; N-(tert-butyl)-3-((2-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxolsoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide; N-(tert-butyl)-3-((2-((4-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-1-yl)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide; N-(tert-butyl)-3-((2-((4-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-1-yl)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide; N-(tert-butyl)-3-((2-((4-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-1-yl)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide; N-(tert-butyl)-3-((2-((4-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-1-yl)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide; N-(tert-butyl)-3-((2-((4-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide; N-(tert-butyl)-3-((2-((4-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide; N-(tert-butyl)-3-((2-((4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide; N-(tert-butyl)-3-((2-((4-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide; N-(tert-butyl)-3-((2-((4-(1-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide; N-(tert-butyl)-3-((2-((4-(1-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide; N-(tert-butyl)-3-((2-((4-(1-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide; N-(tert-butyl)-3-((2-((4-(1-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide; N-(tert-butyl)-3-((2-((4-(2-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-l-yl)ethoxy)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide; N-(tert-butyl)-3-((2-((4-(2-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-l-yl)ethoxy)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide; N-(tert-butyl)-3-((2-((4-(2-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-l-yl)ethoxy)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide; N-(tert-butyl)-3-((2-((4-(2-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-l-yl)ethoxy)phenyl)amino)-5-methylpyrimidin-4-yl)amino)benzenesulfonamide; 2-((2-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-l-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide; 2-((2-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-l-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide; 2-((2-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-l-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide; 2-((2-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-l-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide; 2-((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)amino)piperidin-1-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide; 2-((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)amino)piperidin-l-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide; 2-((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)amino)piperidin-l-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide; 2-((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)amino)piperidin-l-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide; 2-((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide; 2-((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide; 2-((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide; 2-((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide; 2-((2-((4-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide; 2-((2-((4-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide; 2-((2-((4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide; 2-((2-((4-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide; N-(3-(((2-((4-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyrazin-2-yl)-N-methylmethanesulfonamide; N-(3-(((2-((4-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyrazin-2-yl)-N-methylmethanesulfonamide; N-(3-(((2-((4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyrazin-2-yl)-N-methylmethanesulfonamide; N-(3-(((2-((4-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyrazin-2-yl)-N-methylmethanesulfonamide; N-(3-(((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-3-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyrazin-2-yl)-N-methylmethanesulfonamide; N-(3-(((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-3-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyrazin-2-yl)-N-methylmethanesulfonamide; N-(3-(((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-3-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyrazin-2-yl)-N-methylmethanesulfonamide; N-(3-(((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-3-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyrazin-2-yl)-N-methylmethanesulfonamide; N-(3-(((2-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyrazin-2-yl)-N-methylmethanesulfonamide; N-(3-(((2-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyrazin-2-yl)-N-methylmethanesulfonamide; N-(3-(((2-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyrazin-2-yl)-N-methylmethanesulfonamide; N-(3-(((2-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyrazin-2-yl)-N-methylmethanesulfonamide; N-(3-(((2-((4-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide; N-(3-(((2-((4-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide; N-(3-(((2-((4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide; N-(3-(((2-((4-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide; N-(3-(((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide; N-(3-(((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide; N-(3-(((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide; N-(3-(((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide; N-(3-(((2-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide; N-(3-(((2-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide; N-(3-(((2-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide; N-(3-(((2-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide; N-(3-(((2-((4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)amino)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide; N-(3-(((2-((4-(((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)amino)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide; N-(3-(((2-((4-(((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)amino)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide; N-(3-(((2-((4-(((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)amino)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide; N-(3-(((2-((4-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyridin-2-yl)-N-methylmethanesulfonamide; N-(3-(((2-((4-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyridin-2-yl)-N-methylmethanesulfonamide; N-(3-(((2-((4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyridin-2-yl)-N-methylmethanesulfonamide; N-(3-(((2-((4-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyridin-2-yl)-N-methylmethanesulfonamide; N-(3-(((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyridin-2-yl)-N-methylmethanesulfonamide; N-(3-(((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyridin-2-yl)-N-methylmethanesulfonamide; N-(3-(((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyridin-2-yl)-N-methylmethanesulfonamide; N-(3-(((2-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyridin-2-yl)-N-methylmethanesulfonamide; N-(3-(((2-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyridin-2-yl)-N-methylmethanesulfonamide; N-(3-(((2-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyridin-2-yl)-N-methylmethanesulfonamide; N-(3-(((2-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyridin-2-yl)-N-methylmethanesulfonamide; N-(3-(((2-((4-(4-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)piperidin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyridin-2-yl)-N-methylmethanesulfonamide; 2-(2-((cyclopropylmethyl)amino)pyridin-4-yl)-N-(3-(difluoromethyl)-1-(1-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)-1H-pyrazol-4-yl)oxazole-4-carboxamide; 2-(2-((cyclopropylmethyl)amino)pyridin-4-yl)-N-(3-(difluoromethyl)-1-(1-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)-1H-pyrazol-4-yl)oxazole-4-carboxamide; 2-(2-((cyclopropylmethyl)amino)pyridin-4-yl)-N-(3-(difluoromethyl)-1-(1-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)-1H-pyrazol-4-yl)oxazole-4-carboxamide; 2-(2-((cyclopropylmethyl)amino)pyridin-4-yl)-N-(3-(difluoromethyl)-1-(1-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)-1H-pyrazol-4-yl)oxazole-4-carboxamide; N-(3-(difluoromethyl)-1-(1-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)-1H-pyrazol-4-yl)-5-morpholinopyrazolo[1,5-a]pyrimidine-3-carboxamide; N-(3-(difluoromethyl)-1-(1-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)-1H-pyrazol-4-yl)-5-morpholinopyrazolo[1,5-a]pyrimidine-3-carboxamide; N-(3-(difluoromethyl)-1-(1-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)-1H-pyrazol-4-yl)-5-morpholinopyrazolo[1,5-a]pyrimidine-3-carboxamide; N-(3-(difluoromethyl)-1-(1-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)-1H-pyrazol-4-yl)-5-morpholinopyrazolo[1,5-a]pyrimidine-3-carboxamide; N-(2-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)-5-((R)-3-hydroxypyrrolidin-1-yl)oxazolo[4,5-b]pyridin-6-yl)-2-(2-methylpyridin-4-yl)oxazole-4-carboxamide; N-(2-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)-5-((R)-3-hydroxypyrrolidin-1-yl)oxazolo[4,5-b]pyridin-6-yl)-2-(2-methylpyridin-4-yl)oxazole-4-carboxamide; N-(2-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)-5-((R)-3-hydroxypyrrolidin-1-yl)oxazolo[4,5-b]pyridin-6-yl)-2-(2-methylpyridin-4-yl)oxazole-4-carboxamide; N-(2-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)-5-((R)-3-hydroxypyrrolidin-1-yl)oxazolo[4,5-b]pyridin-6-yl)-2-(2-methylpyridin-4-yl)oxazole-4-carboxamide; 4-((1-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)ethynyl)-1-(((2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl)methoxy)-7-methoxyisoquinoline-6-carboxamide; 4-((1-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)ethynyl)-1-(((2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl)methoxy)-7-methoxyisoquinoline-6-carboxamide; 4-((1-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)ethynyl)-1-(((2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl)methoxy)-7-methoxyisoquinoline-6-carboxamide; 4-((1-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)ethynyl)-1-(((2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl)methoxy)-7-methoxyisoquinoline-6-carboxamide; 6-(6-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)pyridin-3-yl)-1-isopropyl-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide; 6-(6-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)pyridin-3-yl)-1-isopropyl-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide; 6-(6-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)pyridin-3-yl)-1-isopropyl-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide; 6-(6-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)pyridin-3-yl)-1-isopropyl-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide; 6-(6-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)pyridin-3-yl)-1-isopropyl-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide; 6-(6-(4-(((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)pyridin-3-yl)-1-isopropyl-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide; 6-(6-(4-(((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)pyridin-3-yl)-1-isopropyl-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide; 6-(6-(4-(((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)(methyl)amino)piperidin-1-yl)pyridin-3-yl)-1-isopropyl-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide; 6-(6-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-1-yl)pyridin-3-yl)-1-isopropyl-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide; 6-(6-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-1-yl)pyridin-3-yl)-1-isopropyl-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide; 6-(6-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-1-yl)pyridin-3-yl)-1-isopropyl-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide; 6-(6-(4-(1-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperidin-4-yl)piperazin-1-yl)pyridin-3-yl)-1-isopropyl-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide; N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4'-((4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-[1,1'-biphenyl]-3 -carboxamide; N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4'-((4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-[1,1'-biphenyl]-3-carboxamide; N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4'-((4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-[1,1'-biphenyl]-3-carboxamide; N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4'-((4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-[1,1'-biphenyl]-3-carboxamide; N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4'-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-[1,1'-biphenyl] -3 -carboxamide; N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4'-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-[1,1'-biphenyl]-3-carboxamide; N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4'-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-[1,1'-biphenyl]-3-carboxamide; N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4'-(4-((2-(2,6-dioxopiperidin-3-yl)-7-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-[1,1'-biphenyl]-3-carboxamide; N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4'-(4-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-[1,1'-biphenyl]-3-carboxamide; N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4'-(4-((2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-[1,1'-biphenyl]-3-carboxamide; N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4'-(4-((2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-5-yl)methyl)piperazin-1-yl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-[1,1'-biphenyl]-...

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