Method for preparing a composition with low ecotoxicological impact

Abstract

The invention relates to a method for manufacturing a composition referred to as a low ecotoxicological impact composition, wherein: - an initial composition comprising at least two distinct compounds is chosen, each compound having, in said initial composition, a predetermined initial mass fraction Ci, - for each compound, there is at least one concentration Ti of said compound having no observed effect on at least one predetermined organism representative of the toxicity of said compound with respect to said living organism of a terrestrial and / or aquatic ecosystem, said concentration Ti being expressed in milligrams per litre, - for each compound, there is at least one concentration P representative of the exposure of said terrestrial and / or aquatic ecosystem to said compound, said concentration P being expressed in milligrams per litre, - for each compound, a maximum threshold mass fraction Xi is calculated from a quotient according to formula (I), - said low ecotoxicological impact composition is prepared by mixing said compounds in such a way that each compound has, in said low ecotoxicological impact composition, a final mass fraction Fi which is less than or equal to said threshold mass fraction Xi.

Description

[0001] DESCRIPTION

[0002] TITLE OF THE INVENTION: PROCESS FOR PREPARING A COMPOSITION WITH LOW ECOTOXICOLOGICAL IMPACT

[0003] Technical field of the invention

[0004] The invention relates to a process for preparing a composition, such as a cosmetic composition or a detergent composition, having a low ecotoxicological impact.

[0005] Technological background

[0006] Many detergent compositions (detergents, household cleaners, etc.) and most cosmetic compositions are, during or after use, rinsed with water and are therefore discharged into wastewater intended for treatment by treatment plants, or sometimes even directly discharged into the environment. Only a very small proportion of the chemical compounds contained in these compositions are actually treated and eliminated by water treatment treatments and many chemical compounds are still present in the discharges, particularly discharges into rivers.

[0007] For example, cosmetic compositions are known which include compounds with limited ecotoxicological impact on the environment and natural ecosystems.

[0008] WO2018145921 describes fungicidal compositions comprising triazole compounds that are more environmentally friendly.

[0009] WO2019207129 describes ultraviolet filtering compositions, their process for preparation and use as well as the determination of an ecotoxicological score after determination of an environmental profile of each UV filter.

[0010] However, it is difficult to assess the ecotoxicity of a formula and to prepare a reliable composition whose ecotoxicological impact is known and controlled.

[0011] Objectives of the invention

[0012] The invention aims to overcome these drawbacks as well as the risks of pollution of natural environments.

[0013] The invention aims to provide a process for preparing a composition having a low ecotoxicological impact.

[0014] Statement of the invention

[0015] To do this, the invention relates to a method for preparing a composition, called a composition with low ecotoxicological impact, in which: an initial composition is chosen comprising at least two distinct compounds, each compound having, in said initial composition, a predetermined initial mass fraction Ci relative to the total mass of said initial composition, for each compound, at least one concentration Ti of said compound is available without observed effect on at least one predetermined organism representative of the toxicity of said compound with respect to said living organism of a terrestrial and / or aquatic ecosystem, said concentration Ti being a mass concentration (expressed for example in milligrams per liter (mg / L)), for each compound, at least one concentration P is available representative of the exposure of said terrestrial and / or aquatic ecosystem to said initial composition,said concentration P being a mass concentration (expressed for example in milligrams per liter (mg / L)), for each compound, a threshold mass fraction Xi (or maximum mass fraction) is calculated from a quotient according to the following formula [Math 1]: 100, said composition with low ecotoxicological impact is prepared by mixing said compounds in such a way that each compound has, in said composition with low ecotoxicological impact, a final mass fraction Fi relative to the total mass of said composition with low ecotoxicological impact, less than or equal to said threshold mass fraction Xi of said compound.

[0016] A method according to the invention makes it possible to prepare compositions such as cosmetic compositions or even detergent compositions, having a low ecotoxicological impact, the ecotoxicological impact of each compound of a composition being particularly reliable since it makes it possible to take into account not only the toxicity of each compound present in the composition, but also the exposure of terrestrial and / or aquatic ecosystems, for example by taking into account the type of composition concerned and its use (quantity of water used associated with each use . . .). From a predetermined initial composition, it will therefore only be necessary to reduce the initial mass fraction of a compound (ingredient) if it is at least equal to (or strictly greater than) the threshold mass fraction Xi.If all the initial mass fractions Ci are less than or equal to their threshold mass fraction Xi, it is therefore not necessary to modify the proportions of the compounds in said composition. However, in this case, the process makes it easier to choose to modify certain mass fractions of certain compounds in the composition in order to further limit its ecotoxicological impact.

[0017] Advantageously and according to the invention, when said method is carried out, at least one compound of said initial composition has a mass fraction Ci at least equal to the threshold mass fraction Xi of said compound.

[0018] The concentration P is representative of the exposure of said terrestrial ecosystem and / or said aquatic ecosystem to a predetermined composition (or initial composition in particular). Advantageously and according to the invention, P represents a predicted environmental concentration of a predetermined composition taking into account its use and its release into the environment.

[0019] Throughout the text, the expression "toxicity of each compound" means the toxicity or "ecotoxicity" of said compound with respect to the environment and, in particular, the toxicity represented by the no observed effect concentration ("NOEC") on at least one predetermined organism. This may be the aquatic ecotoxicity of said compound, i.e. the toxicity with respect to one or more of the following categories of aquatic and / or terrestrial organisms: microorganisms (for example, Photobacterium phosphoreum), aquatic plants other than algae, aquatic algae, cyanobacteria, aquatic invertebrates (for example, daphnia or branchiopod crustaceans of the Daphniidae family, in particular those belonging to the species Daphna magna or Cerodaphnia spinata), fish (for example, fish belonging to the species Lucioperca lucioperca L.and / or fish belonging to the species Danio rerio and / or the species Lebistes reticulatus and / or the species Guppy). It may also concern sediment ecotoxicity, terrestrial ecotoxicity, i.e. toxicity to soil microorganisms, terrestrial plants, terrestrial arthropods, soil macroorganisms other than arthropods and / or birds. The no observed effect concentration of each compound is evaluated from the results of biological tests (bioassays).

[0020] Advantageously and according to the invention, for each initial composition, a percentage is calculated, called the success percentage, representative of the estimated chances of success of said initial composition in at least one biological test, said success percentage being calculated according to the following formula [Math 2]:

[0021] [Math 2]

[0022] SCi x 95

[0023] 100 -

[0024] 100 x Ti xa

[0025] SCi representing the sum of the initial mass fractions of each compound of said initial composition, and a being a non-zero coefficient at least equal to 1.

[0026] Advantageously and according to the invention, the coefficient a is between 1 and 10.

[0027] Advantageously and according to the invention, when said initial composition comprises water, for each compound of said initial composition, a mass fraction, called corrected initial mass fraction Qi, is calculated according to the formula

[0028] [Math 3] next:

[0029] [Math 3] a

[0030] SCi — SCi representing the sum of the initial mass fractions of each compound of said initial composition, and

[0031] Water representing the mass fraction of water in said initial composition.

[0032] This corrected initial mass fraction therefore takes into account the total mass of said initial composition from which is subtracted the mass of water contained, where applicable, in said initial composition.

[0033] Thus, advantageously and according to the invention, for each initial composition, a percentage is calculated, called the corrected success percentage, representative of the estimated chances of success of said initial composition in at least one biological test, said success percentage being calculated according to the following formula [Math 4]:

[0034] [Math 4]

[0035] ZQi x 95

[0036] 100 - - -

[0037] 100 x Ti xa

[0038] SQi representing the sum of the corrected initial mass fractions of each compound of said initial composition, and a being a non-zero coefficient at least equal to 1.

[0039] Advantageously and according to the invention, said method further comprises the following steps: the value of a predetermined total mass M used per day by a user of said initial composition is available (in particular in grams (g)), the value of a total volume of water V used in conjunction with a use of said initial composition is available (in particular in liters), said parameter P representative of the exposure of said terrestrial and / or aquatic ecosystem to said composition is calculated according to the following formula:

[0040] [Math 5]

[0041] M x 1000

[0042] V xaa being a non-zero coefficient at least equal to 1.

[0043] Advantageously and according to the invention, for each compound, at least one parameter Tli is available which is representative of the aquatic toxicity of said compound, said aquatic ecotoxicity being representative of the toxicity of said compound with respect to at least one organism chosen from the group consisting of microorganisms (in particular Photobacterium phosphoreum), aquatic plants other than algae, aquatic algae, cyanobacteria, aquatic invertebrates (in particular Daphnia or branchiopod crustaceans of the Daphniidae family) and fish (in particular fish belonging to the species Lucioperca lucioperca L. and / or fish belonging to the species Danio rerio and / or the species Lebistes reticulatus and / or the species Guppy).

[0044] Advantageously and according to the invention, for each compound, at least one parameter T2i is available, representative of the terrestrial toxicity of said compound with respect to at least one organism chosen from the group formed by soil microorganisms, terrestrial plants, terrestrial arthropods, soil macroorganisms (other than arthropods) and birds.

[0045] In particular, for each parameter Ti representative of the toxicity of a compound towards at least one living organism in a terrestrial and / or aquatic ecosystem (notably Tli or T2i), if several values ​​are available, the lowest value is chosen. This makes it possible to cover the risks for all organisms.

[0046] Many household or cosmetic products are used with water, in diluted form or via their rinsing, extemporaneous or deferred (for example in the case of a moisturizing cream, not intended to be rinsed, but which is nevertheless partly evacuated into the water for example when its user washes the skin on which such a cream has been previously applied), the rinsing water being discharged into wastewater.

[0047] Advantageously and according to the invention, a composition with low ecotoxicological impact is prepared, chosen from the group consisting of shampoos, conditioners, masks (hair masks for example), skin cleansing gels, micellar waters, cleansing milks, foundations, moisturizing creams, tinted creams and sun creams. Advantageously and according to the invention, a composition with low ecotoxicological impact is prepared, chosen from the group consisting of detergent compositions, dishwashing liquids, dishwasher compositions, laundry detergents, toilet cleaning compositions, degreasers and surface cleaners.

[0048] Advantageously and according to the invention, after having prepared said composition with low ecotoxicological impact, at least one biological test (or bioassay) is carried out to determine the toxicity of said composition with low ecotoxicological impact (on at least one living organism). Advantageously and according to the invention, each biological test complies with the OECD Guidelines for the Testing of Chemicals, Section 2, in particular test No. 202 (Daphnia sp., immediate immobilization test) dated November 23, 2004 and test No. 203 (Fish, acute toxicity test) dated June 18, 2019.

[0049] The invention also relates to a composition obtained by such a method according to the invention.

[0050] The invention also relates to a method for the ecotoxicological evaluation of a composition, in which: an initial composition is chosen comprising at least two distinct compounds, each compound having, in said initial composition, a predetermined initial mass fraction Ci relative to the total mass of said initial composition, for each compound, at least one concentration Ti of said compound is available without observed effect on at least one predetermined organism representative of the toxicity of said compound with respect to said living organism of a terrestrial and / or aquatic ecosystem, said concentration Ti being a mass concentration (expressed for example in milligrams per liter (mg / L)), for each compound, at least one concentration P is available representative of the exposure of said terrestrial and / or aquatic ecosystem to said initial composition,said concentration P being a mass concentration (expressed for example in milligrams per liter (mg / L)), for each compound, a threshold mass fraction Xi (or maximum mass fraction) is calculated from a quotient according to the formula 100,

[0051] The invention also relates to an ecotoxicological evaluation system configured to implement said method for ecotoxicological evaluation of a composition, said ecotoxicological evaluation system comprising a module for calculating a threshold mass fraction Xi for each compound of said composition. Said ecotoxicological evaluation system further comprises at least one memory in which data corresponding to the initial mass fraction Ci of each compound, to the concentration P and to the concentration Ti of each compound without observed effect on at least one predetermined organism representative of the toxicity with respect to said living organism of a terrestrial and / or aquatic ecosystem are capable of being recorded.

[0052] Throughout the text, a module is defined as a software element, a subset of a software program, which can be compiled separately, either for independent use or to be assembled with other modules of a program, or a hardware element, or a combination of a hardware element and a software subroutine. Such a hardware element may include an application-specific integrated circuit (better known by the acronym ASIC for the English term Application-Specific Integrated Circuit) or a programmable logic circuit (better known by the acronym FPGA for the English term Field-Programmable Gate Array) or a specialized microprocessor circuit (better known by the acronym DSP for the English term Digital Signal Processor) or any equivalent hardware or any combination of the aforementioned hardware. Generally speaking, a module is therefore an element (software and / or hardware) which makes it possible to perform a function.The invention also relates to a method and a composition with low ecotoxicological impact, characterized in combination by all or part of the characteristics mentioned above or below.

[0053] Other aims, characteristics and advantages of the invention will appear on reading the following description given solely for non-limiting purposes.

[0054] Detailed description of an embodiment of the invention

[0055] The method according to the invention comprises the following successive steps: an initial composition comprising at least two distinct compounds is chosen, each compound having, in said initial composition, a predetermined initial mass fraction Ci relative to the total mass of said initial composition, for each compound, at least one concentration Ti of said compound is available without observed effect on at least one predetermined organism representative of the toxicity of said compound with respect to said living organism of a terrestrial and / or aquatic ecosystem, said concentration Ti being a mass concentration (for example in milligrams per liter (mg / L)), at least one mass concentration P is available or calculated representative of the exposure of a terrestrial and / or aquatic ecosystem to the composition according to the following formula:

[0056] [Math 5]

[0057] M x 1000

[0058] V xa

[0059] M being a predetermined total mass M used per day by a user of the initial composition in grams (g),

[0060] V being a total volume of water V used jointly with a use of the initial composition in liters (L), a being a non-zero coefficient at least equal to 1. for each compound, a maximum threshold mass fraction Xi is calculated from a quotient according to the following formula [Math 1]: [Math 1] 100 for each initial composition, we can also calculate the percentage of success representative of the estimated chances of success of the initial composition in at least one biological test, according to the following formula [Math 2]:

[0061] [Math 2]

[0062] SCi x 95 100 -

[0063] 100 x Ti xa

[0064] SCi representing the sum of the initial mass fractions of each compound of said initial composition, and a being a non-zero coefficient at least equal to 1, for example between 1 and 10, finally, at least one composition with low ecotoxicological impact is prepared by mixing the compounds in such a way that each compound has, in the composition with low ecotoxicological impact, a final mass fraction Fi less than or equal to the threshold mass fraction Xi, and in particular in such a way that the composition with low ecotoxicological impact has a success percentage at least equal to 70%, in particular at least equal to 80% or even 90%.

[0065] Furthermore, when the initial composition includes water, for each compound of the initial composition, we can calculate a corrected initial mass fraction Qi according to the following formula [Math 3]:

[0066] [Math 3] a

[0067] SCi — Ceau

[0068] SCi representing the sum of the initial mass fractions of each compound of the initial composition, and

[0069] Ceau representing the mass fraction of water in the initial composition. Thus, we can calculate a corrected success percentage according to the following formula [Math 4]:

[0070] [Math 4]

[0071] 100 x Ti xa

[0072] ZQi representing the sum of the corrected initial mass fractions of each compound of the initial composition.

[0073] Such a process therefore makes it possible to prepare a composition with low ecotoxicological impact chosen from the group consisting of shampoos, conditioners, masks for keratin fibers, skin cleansing gels, micellar waters, makeup remover milks, foundations, moisturizers, tinted creams and sun creams, or chosen from the group consisting of detergent compositions, dishwashing liquids, dishwasher compositions, laundry detergents, toilet cleaning compositions, degreasers, surface cleaners and fungicides.

[0074] EXAMPLE 1

[0075] We want to prepare a dishwashing liquid composition. The average amount of dishwashing liquid used is 12.80 grams per day and is used in combination with a volume of water of around 5 liters.

[0076] From this, we deduce an estimated concentration of dishwashing liquid released into a river, for example (in the worst-case scenario where 100% of the dishwashing liquid composition is not treated by a treatment plant) of 77.576 mg / L (using a predetermined dilution factor of 33 in this case).

[0077] We have an initial composition comprising 8.00% by mass of sodium laureth sulfate (sodium 2-dodecoxyethyl sulfate), 3.50% by mass of sodium lauryl sulfate (sodium dodecyl sulfate), 2.00% by mass of sodium chloride, 0.21% by mass of caprylyl / capryl glucoside (decyl D-gluco-hexopyranoside) and 0.20% by mass of sodium benzoate in water (i.e. 86.09% by mass). The composition therefore comprises 13.91% by mass of compounds in water. We can therefore divide the value of the mass fraction of each compound by the sum of these mass percentages (i.e. 13.91) to obtain the initial mass fraction Qi of each compound.

[0078] For each compound, we have the value of a parameter Ti representative of its toxicity towards at least one living organism in a terrestrial and / or aquatic ecosystem as well as the value of a parameter P representative of the exposure of said terrestrial and / or aquatic ecosystem to the composition, P being equal to 77.576 mg / L.

[0079] The table below lists the values ​​of the parameters of each compound of this composition as well as those of the threshold mass fractions Xi (and calculation of the parameters) calculated from the mass fractions and the parameters Ti, Qi and P of each compound.

[0080] [Table 1]

[0081] It is therefore necessary to correct the mass fractions of sodium laureth sulfate, sodium lauryl sulfate and sodium benzoate in the composition in order to limit the ecotoxicological impact of this dishwashing liquid.

[0082] The corrected success rate for bacteria is 96%. The corrected success rate for algae is 39%. The corrected success rate for daphnia is -11%. The corrected success rate for fish is -49%. Here, for example, we consider that since the success rate is less than 70% for algae, daphnia and fish, the mass fractions of at least some compounds in the composition must be modified for these organisms.For example, we choose to correct the mass fractions of each compound accordingly so as to prepare a dishwashing liquid composition with low ecotoxicological impact comprising 0.05% by mass of sodium laureth sulfate (2-dodecoxyethyl sodium sulfate), 0.10% by mass of sodium lauryl sulfate (sodium dodecyl sulfate), 13.34% by mass of sodium chloride, 0.40% by mass of caprylyl / capryl glucoside (decyl D-gluco-hexopyranoside) and 0.02% by mass of sodium benzoate in water.

[0083] The invention is not limited to the embodiments described. In particular, said threshold mass fraction Xi can be corrected by certain correction factors depending on the type of composition concerned, the organisms and / or the ecosystems considered... The value of the coefficient a can for example vary and be adapted according to the cases.

Claims

CLAIMS 1. Process for preparing a composition, called a composition with low ecotoxicological impact, in which: an initial composition is chosen comprising at least two distinct compounds, each compound having, in said initial composition, a predetermined initial mass fraction Ci relative to the total mass of said initial composition, for each compound, at least one concentration Ti of said compound is available without observed effect on at least one predetermined organism representative of the toxicity of said compound with respect to said living organism of a terrestrial and / or aquatic ecosystem, said concentration Ti being a mass concentration, for each compound, at least one concentration P is available representative of the exposure of said terrestrial and / or aquatic ecosystem to said initial composition, said concentration P being a mass concentration, for each compound,we calculate a threshold mass fraction Xi from a quotient according to the following formula [Math 1]:, [Math 1] 100 said composition with low ecotoxicological impact is prepared by mixing said compounds such that each compound has, in said composition with low ecotoxicological impact, a final mass fraction Fi, relative to the total mass of said composition with low ecotoxicological impact, less than or equal to said threshold mass fraction Xi of said compound.

2. Method according to claim 1, characterized in that, for each initial composition, a percentage is calculated, called the success percentage, representative of the estimated chances of success of said initial composition. to at least one biological test, said success percentage being calculated according to the following formula [Math 2]: [Math 2] SCi x 95 100 - 100 x Ti xa SCi representing the sum of the initial mass fractions of each compound of said initial composition, and a being a non-zero coefficient at least equal to 1.

3. Method according to any one of claims 1 or 2, characterized in that, for each compound, at least one parameter Tli is available representative of the aquatic toxicity of said compound, said aquatic ecotoxicity being representative of the toxicity of said compound with respect to at least one organism chosen from the group formed by microorganisms (in particular photobacterium phosphoreum), aquatic plants other than algae, aquatic algae, cyanobacteria, aquatic invertebrates (in particular daphnia or branchiopod crustaceans of the Daphniidae family) and fish (in particular fish belonging to the species Lucioperca lucioperca L. and / or fish belonging to the species Lebistes reticulatus and / or the species Guppy).

4. Method according to one of claims 1 to 3, characterized in that, for each compound, at least one parameter T2i is available representative of the terrestrial toxicity of said compound with respect to at least one organism chosen from the group formed by soil microorganisms, terrestrial plants, terrestrial arthropods, soil macroorganisms other than arthropods and birds.

5. Method according to one of claims 1 to 4, characterized in that, when said initial composition comprises water, for each compound of said initial composition, a mass fraction, called corrected initial mass fraction Qi, is calculated according to the following formula [Math 3]: [Math 3] Here SCi — Ceau Water representing the mass fraction of water in said initial composition.

6. Method according to claim 5, characterized in that, for each initial composition, a percentage is calculated, called the corrected success percentage, representative of the estimated chances of success of said initial composition in at least one biological test, said corrected success percentage being calculated according to the following formula [Math 4]: [Math 4] SQi x 95 100 - - - 100 x Ti xa SQi representing the sum of the corrected initial mass fractions of each compound of said initial composition.

7. Method according to one of claims 1 to 6, characterized in that it further comprises the following steps: the value of a predetermined total mass M used per day by a user of said initial composition is available, the value of a total volume of water V used in conjunction with a use of said initial composition is available, said parameter P representative of the exposure of said terrestrial and / or aquatic ecosystem to said composition is calculated according to the following formula [Math 5]: [Math 5] M x 1000 V xa 8. Method according to one of claims 1 to 7, characterized in that a composition with low ecotoxicological impact is prepared, chosen from the group consisting of shampoos, conditioners, keratin fiber masks, skin cleansing gels, micellar waters, cleansing milks, foundations, moisturizers, tinted creams and sunscreens.

9. Method according to one of claims 1 to 8, characterized in that a composition with low ecotoxicological impact is prepared, chosen from the group consisting of detergent compositions, dishwashing liquids, dishwasher compositions, detergents, toilet cleaning compositions, degreasers, surface cleaners and fungicides.

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