Btk inhibitor for treating multiple sclerosis

EP4704851A1Pending Publication Date: 2026-03-11BIOGEN MA INC
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Patent Information

Authority / Receiving Office
EP · EP
Patent Type
Applications
Current Assignee / Owner
Filing Date
2024-05-03
Publication Date
2026-03-11

AI Technical Summary

Technical Problem

Current multiple sclerosis (MS) treatments often result in permanent disability progression, limited tolerability, and severe adverse events, with a need for more effective and tolerable therapies that address inflammatory components across various MS types and independently treat disability progression.

Method used

Administering a BTK inhibitor, Compound 1, in oral doses ranging from 200 mg to 1000 mg daily to treat MS, targeting both B cells and myeloid cells to reduce inflammation and slow disability progression.

Benefits of technology

The BTK inhibitor effectively treats MS by reducing inflammation and slowing disability progression, offering a safer and more tolerable option compared to existing therapies, with potential benefits in relapsing and progressive forms of the disease.

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Abstract

The present disclosure provides methods of treating Multiple Sclerosis (MS) using Compound (1) as represented by the structure below or a pharmaceutically acceptable salt thereof.
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