New non-therapeutic use of an extract of Nephelium lappaceum to prevent the appearance and / or reduce unpleasant odors on the skin and / or mucous membranes and / or skin appendages.

Abstract

The invention relates to the non-therapeutic, preferably cosmetic, use of an extract of the plant Nephelium lappaceum to prevent the appearance and / or reduce unpleasant odors, advantageously on the skin and / or mucous membranes and / or skin appendages, particularly the hair. The N. lappaceum extract is used alone or in a composition, topically or orally. The invention also relates to a non-therapeutic treatment method preferably comprising the topical application of the N. lappaceum extract or a composition containing it.

Description

Description Title of the invention: Novel non-therapeutic use of a Nephelium lappaceum extract to prevent the appearance and / or reduce unpleasant odors on the skin and / or mucous membranes and / or skin appendages.

[0001] — Odors perceived as unpleasant have multiple origins such as environmental odors originating from outside, such as urban or industrial odors, of the indoor environment, such as those found in bathrooms, the kitchen, toilets, laundry room, or even unpleasant body odors pleasant. These odors can be classified according to different families of compounds Volatile organic compounds (VOCS) are responsible, in whole or in part, for odors. perceived. The unpleasant hedonic character associated with an odor and its intensity depend on individuals, cultures, and the associated context.

[0002] — The odors originate from volatile odorous compounds of several families among which include aromatic alcohols, aldehydes, aliphatic hydrocarbons and cyclics, ketones, esters, ethers, furan, lactones, sulfur compounds, terpenes. Among the odor compounds usually perceived as unpleasant or dis- Pleasant ones include, among others, sulfur compounds such as thiols (odors) of onions, garlic), carboxylic acids (odor of sweat, vinegar, [cheese], the Nitrogen compounds and amines (ammonia, nicotine, fecal odors).

[0003] Volatile atmospheric compounds from industrial activities, in addition to Their harmful health consequences are also perceived as unpleasant odors. pleasant, especially those derived from nitrogen compounds.

[0004] — Other sources of odor compounds perceived as unpleasant are due to human activity, such as cooking food or using products cleaning, or eliminating unpleasant body odors, especially those caused by... through perspiration or an imbalance of the skin's microbial flora or mucosal.

[0005] — The majority of compositions intended for domestic or cosmetic use for Odor-reducing agents include synthetic chemical molecules such as than fragrant actives. They are also found in perfume compositions. Extracts Plants can be used, often in the form of essential oils. These com- These positions aim to mask unpleasant odors by providing notes odors perceived as positive, that is to say pleasant.

[0006] There is therefore a need in the field of compositions for personal use and do- mestique and more specifically in the field of cosmetics, to provide in- active ingredients capable of preventing the appearance and / or reducing odors perceived as unpleasant, other than by masking them with odor notes perceived as positive. This is precisely the object of the present invention. The applicant has indeed discovered, in a surprising and unexpected way, that an extract of the plant Nephelium lappaceum has the effect of preventing the appearance and / or reducing unpleasant odors, particularly on the skin and / or mucous membranes and / or skin appendages. The plant *N. lappaceum*, also known as rambutan, is a tree found in Southeast Asia, Malaysia, and Indonesia. It grows to a height of 10 to 20 meters and produces a large quantity of fruit. The fruit is known for its organoleptic properties and contains sugars, vitamin C, and iron. Decoctions of the roots or dried leaves have been used to treat fever. Rambutan extracts are already known in cosmetics for specific cosmetic effects. Thus, applications JP2002145730 and CN105534812 respectively describe a rambutan seed extract for its antioxidant, whitening and moisturizing effects. Rambutan oil is also known for its use in the care of keratinous materials, particularly hair. One example is application WO201118278, which discloses the use of rambutan seed oil in a cosmetic composition for hair care. The applicant described in application WO201820300 the use of an extract of the plant N. lappaceum to increase the firmness of the skin and / or mucous membranes, as well as the use of a pericarp extract of said plant to moisturize the skin and / or mucous membranes and / or skin appendages in application WO2019025725. However, to the applicant's knowledge, no prior art discloses the use of an extract of N. lappaceur to prevent the appearance and / or reduce unpleasant odors in general. The advantage of the extract according to the invention is that it is chemically stable and does not cause skin irritation when used in cosmetics. Another advantage is that it can be used in both topical and oral compositions in gel or paste form, particularly for oral mucosa. It can be easily produced on an industrial scale and is also part of the development of a sustainable production sector. A first objective thus concerns the non-therapeutic use, advantageously the non-therapeutic cosmetic use, of an extract of N. lappaceurn to prevent the appearance and / or reduce unpleasant odors, advantageously at the level of the skin and / or mucous membranes and / or skin appendages. The term "cosmetic use" means a non-therapeutic use, that is to say a non-pharmaceutical or non-dermatological use, that is to say a use intended for all or part of healthy skin and / or mucous membrane and / or skin appendage. The term "healthy skin, mucous membranes or skin appendages" means skin, mucous membranes or skin appendages that do not require therapeutic treatment, that do not have infection, scarring, disease, inflammation or skin condition such as candidiasis, impetigo, psoriasis, eczema, acne or dermatitis, or wound, injury and / or other dermatosis. The term “skin” refers to any part of the body and / or face, including the scalp. The term "mucous membrane" refers to the nasal and / or oral and / or vaginal and / or anal mucosa, preferably the oral mucosa. The term “skin appendages” refers to nails and / or hair, particularly beard hair, and / or head hair, preferably head hair. The extract according to the invention can be administered orally or topically. Preferably, it is applied topically. The extract according to the invention is a topically acceptable extract, the term "topically acceptable" being understood as an extract that is non-irritating to the skin or hair, non-toxic, and does not induce an allergic reaction. "Topical application" means the direct application of the extract or a composition, advantageously cosmetic, comprising it to the skin and / or mucous membranes and / or skin appendages, or its vaporization onto the surface of the skin and / or skin appendages, preferably the hair, and / or into the oral mucosa. In one embodiment of the invention, the non-therapeutic, advantageously cosmetic, use of the extract according to the invention includes its application by topical route or that of a composition, advantageously cosmetic, comprising it on all or part of the body and / or face chosen from the legs, feet, armpits, hands, thighs, belly, décolleté, neck, arms, torso, back, face, advantageously the face, most advantageously the scalp, and / or mucous membranes, advantageously the oral mucosa, and / or skin appendages, advantageously the hair. For the purposes of this invention, "unpleasant odors" means bad odors, or odors perceived as strong and / or nauseating, detected and / or detectable, advantageously at the level of the skin and / or mucous membranes and / or skin appendages. These bad odors may be extrinsic odors such as those induced by exhaust fumes or cooking odors, but they may also be intrinsic odors, that is, body odors, and in particular those induced by hormonal imbalances and / or by a dis- balance of the skin and / or mucous flora and / or through perspiration. The term "odor" refers to any volatile compound detected by the human olfactory mucosa. Advantageously, it refers to a malodorous volatile compound. The term "volatile compound" means a chemical molecule emitted whose olfactory perception threshold is at least 0.2 ug / m°, advantageously at least 0.5 ug / m°, further advantageously at least 1 ug / m*. The term "malodorous volatile compound" also refers to a volatile compound possessing a nauseating odor and / or described as strong and / or unpleasant by a majority of the human population and / or perceived as such, favorably by trained volunteers and / or qualified "nose experts," and chosen from: Benzaldehyde (C;H;O; cas no. 100-52-7; molar mass 106.124 g / mol) Benzoic acid ethyl ester (C,H,(O2; cas no. 93-89-0; molar mass 150.17 g / mol) Dodecanal (C,.H,40; case no. 112-54-9; molar mass 184.323 g / mol) 2,4-Decadienal (E, E) (C,oHy6O; case no. 25152-84-5; molar mass 152.237 g / mol) Butanal (C,H;O; case no. 123-72-8; molar mass 72.105 g / mol) Octen-3-o1l (C:H,6O; case n°3391-86-4; molar mass 128.215 g / mol) Benzyl alcohol (C;H;O; case no. 100-51-6; molar mass 108.14 g / mol) Acetone (C;H;O; case no. 67-64-1; molar mass 58.080 g / mol) 1-Octene (CzH6; case no. 111-66-0; molar mass 112.216 g / mol) Pentylcyclopropane (CzHys; case no. 2511-91-3; molar mass 112.216 g / mol) Ethylidenecyclobutane (CsH0; CAS No. 1528-21-8; molar mass 82.146 g / mol) 4,6,8-Trimethyl-1-nonene (CpHuy; case no. 54410-98-9; molar mass 168.324 g / mol) (E)-2-dodecene (C,,H:4; case no. 7206-13-5; molar mass 168.324 g / mol) 4,6-Dimethyl-dodecane (C,4Hap; case no. 61141-72-8; molar mass 198.394 g / mol) Nonane (CgH>»o; case no. 111-84-2; molar mass 128.259 g / mol) Decane (C,OH; case no. 124-18-5; molar mass 142.286 g / mol) Trimethyl-3,3,5-heptane (C,oHz2; case no. 7154-80-5; molar mass 142.286 g / mol) Methacrolein (C,H;O; case no. 78-85-3; molar mass 70.091 g / mol) 2-Methyl-5-undecanone (C,2H240; case no. 50639-02-6; molar mass 184.323 g / mol) 5-Methyl-2-hexanone (C;H,40; case no. 110-12-3; molar mass 114.188 g / mol) 4-cyclopentene-1,3-dione (CsFL,0; case no. 930-60-9; molar mass 96.085 g / mol) Indene (C,H;O; case n°95-13-6; molar mass 116.163 g / mol) Butoxymethylbenzene (C,H,6O; case no. 588-67-0; molar mass 164.248 g / mol) 1-Ethyl-3,5-Dimethylbenzene (C,eH4; case no. 934-74-7; molar mass 134.221 g / mol) Methyl alcohol (CHLO; case no. 67-56-1; molar mass 32.042 g / mol) 1-Isocyanopropane (C,H;N; case no. 627-36-1; molar mass 69.107 g / mol) 2-Methyl-2H-benzotriazole (C-H4N; case no. 16584-00-2; molar mass 133.154 g / mol), Butylcyclohexyl-1,2-benzenedicarboxylic acid ester (C,3H24O4; CAS No. 84-64-O; molar mass 304.38 g / mol), 1,2-benzothiazole (C,H;NS; case no. 272-16-2; molar mass 135.184 g / mol), 1H-inden-1-ethylidene (C, Hp; case no. 2471-83-2; molar mass 142.197 g / mol), Benzene (C,H; case no. 71-43-2; molar mass 78.114 g / mol) Toluene (CH; ; case n°108-88-3; molar mass 92.141 g / mol) Ethylbenzene (C;H y; case no. 100-41-4; molar mass 106.168 g / mol) Styrene (CzH; case no. 100-42-5; molar mass 104.152 g / mol) Propylbenzene (CsH;; cas no. 103-65-1; molar mass 120.195 g / mol) 1-Ethyl,-3-methylbenzene or 3-ethyltoluene (CcHyz; case no. 620-14-4; molar mass 120.195 g / mol) Acetaldehyde (C,HL40; case no. 75-07-0; molar mass 44.053 g / mol) advantageously, Benzaldehyde (CH₂O; case no. 100-52-7; molar mass 106.124 g / mol) Acetone (C,H;O; case no. 67-64-1; molar mass 58.080 g / mol) 4,6,8-Trimethyl-1-nonene (CpHuy; case no. 54410-98-9; molar mass 168.324 g / mol) (E)-2-dodecene (C,,H:4; case no. 7206-13-5; molar mass 168.324 g / mol) Decane (C,OH; case no. 124-18-5; molar mass 142.286 g / mol) Methacrolein (C,H;O; case no. 78-85-3; molar mass 70.091 g / mol) Indene (C,H;O; case n°95-13-6; molar mass 116.163 g / mol) Butylcyclohexyl-1,2-benzenedicarboxylic acid ester (C,3H24O4; CAS No. 84-64-O; molar mass 304.38 g / mol), Benzene (CsHs; case no. 71-43-2; molar mass 78.114 g / mol) Toluene (C,H;; case n°108-88-3; molar mass 92.141 g / mol) Ethylbenzene (CzH y; case no. 100-41-4; molar mass 106.168 g / mol) Styrene (CzH; case no. 100-42-5; molar mass 104.152 g / mol) Propylbenzene (CoH2; CAS No. 103-65-1; molar mass 120.195 g / mol) 1-Ethyl,-3-methylbenzene or 3-ethyltoluene (CeHz; case no. 620-14-4; molar mass 120.195 g / mol) still advantageously, Benzaldehyde (C;H;O; case no. 100-52-7; molar mass 106.124 g / mol) Benzene (C,H; case no. 71-43-2; molar mass 78.114 g / mol) Toluene (C,H;; case n°108-88-3; molar mass 92.141 g / mol) Ethylbenzene (C:H,, ; case no. 100-41-4; molar mass 106.168 g / mol) Styrene (CzH; case no. 100-42-5; molar mass 104.152 g / mol) Propylbenzene (C,H;; case no. 103-65-1; molar mass 120.195 g / mol) 1-Ethyl,-3-methylbenzene or 3-ethyltoluene (C:H>; case no. 620-14-4; molar mass 120.195 g / mol) Even more advantageously the volatile odorant compound is benzaldehyde (C;He O; case no. 100-52-7; molar mass 106.124 g / mol). Specifically, "preventing the appearance and / or reducing unpleasant odors" on the skin and / or mucous membranes and / or skin appendages means reducing the release of at least one volatile compound, advantageously malodorous, chosen from the compounds listed above, on the skin and / or mucous membranes, preferably the oral mucosa, and / or skin appendages, preferably the hair. Alternatively, it means reducing the adhesion and / or penetration of at least one volatile compound, advantageously malodorous, chosen from the compounds listed above, on the skin and / or mucous membranes, preferably the oral mucosa, and / or skin appendages, preferably the hair.Alternatively, this means reducing the biological and / or chemical reactions responsible for the formation of at least one volatile compound, advantageously malodorous, chosen from the compounds above, advantageously on the skin and / or mucous membranes and / or skin appendages. Alternatively still, "preventing the appearance and / or reducing unpleasant odors on the skin and / or mucous membranes and / or skin appendages" means reducing the quantity and / or intensity of at least one volatile odorous compound, advantageously malodorous, perceived by humans, as defined below. Thus, in one embodiment, the extract according to the invention is effective in preventing the appearance and / or reducing unpleasant odors on the skin and / or mucous membranes and / or skin appendages when the quantity of at least one malodorous volatile compound chosen from the above, detected on the skin and / or mucous membranes and / or skin appendages is reduced by at least 10%, preferably by at least 15%, advantageously by at least 20% and further advantageously by at least 50% in the presence of the extract according to the invention or a composition comprising it, compared to the quantity of the malodorous volatile compound detected without application of the extract according to the invention or a composition comprising it, on the skin, mucous membranes and / or skin appendages. In an advantageous embodiment of the invention, it is at least one malodorous volatile compound chosen from those mentioned above detected in a pollution chamber in the presence of skin and / or mucous membranes and / or skin appendages, which are subjected to exhaust gases, under the conditions as described in application WO2019020455. Advantageously, it is hair, very advantageously strands of hair. Preferably, this or these foul-smelling volatile compound(s) are not detected in the pollution chamber in the absence of exhaust gas. In a preferred embodiment, the malodorous volatile compound(s) will be detected by gas chromatography coupled to mass spectrometry (GC-MS), after thermal desorption on Tenax® tubes. Preferably, this detection is carried out after application of the extract according to the invention or of a composition, preferably cosmetic, comprising it on the hair, more preferably strands of hair, after exposure to exhaust gases in a pollution chamber. Advantageously, the applied composition shall comprise the extract according to the invention, preferably at a final concentration of 0.02% by weight of said extract relative to the total weight of the composition. Preferably, it shall be a seed extract, and even more preferably, a seed extract prepared according to Example 1a) under the conditions described in Example 2. The extract according to the invention is also considered to be in an effective quantity to prevent the appearance and / or reduce unpleasant odors on the skin and / or mucous membranes and / or skin appendages, when the intensity of at least one malodorous volatile compound is reduced by at least 25%, preferably by at least 50%, even more preferably by at least 65% after application to the skin and / or skin appendages and / or mucous membranes of the extract according to the invention or of a composition comprising it and after exposure to exhaust gases in a pollution chamber, compared to the level of intensity detected after application of a composition not comprising said extract or without extract. In a preferred embodiment of the invention, the application is carried out on the hair, advantageously on strands of hair. Even more advantageously, the applied composition shall include an extract of N. lappaceum, advantageously in a final concentration of 0.02% by weight of said extract relative to the total weight of the composition. Preferably, the extract is a seed extract, and even more preferably it is the seed extract prepared according to example (a) as described in example 5 In a particularly advantageous embodiment, this detection of The intensity of the odorous volatile compound(s) is determined by sensory analysis at the column outlet after separation of the volatile compounds by gas chromatography, the said volatile compounds having been desorbed by thermal desorption on Tenax® tubes, under the conditions described in example 2. Alternatively, the extract according to the invention is considered to be in an effective quantity for preventing the appearance and / or reducing unpleasant odors on the skin and / or mucous membranes and / or skin appendages, when the average grade value of the odors perceived on a scale of 1 to 9 is reduced by at least 1, advantageously by at least 2, after application to the skin and / or skin appendages and / or mucous membranes, of the extract according to the invention or of a composition comprising it and then exposure to exhaust gases in a pollution chamber, compared to the average grade value perceived under the same conditions in the absence of the extract according to the invention or of a composition comprising it, it being understood that the grade value 1 corresponds to the lowest perceived odor intensity and the value 9 corresponds to the highest. In a preferred embodiment, this decrease in the average grade value is assessed by a panel of 30 volunteers, after olfactory analysis of hair strands exposed to exhaust gases in a pollution chamber, under the conditions described in example 3. Advantageously, the composition applied to the hair strands will comprise an extract of N. lappaceum at a final concentration of 0.02% by weight of said extract relative to the total weight of the composition. Preferably, this is a seed extract, and even more preferably, it is the seed extract prepared according to example (a). The extract according to the invention may be all or part of the N. Jappaceum plant selected from the roots, leaves, seeds, fruit, branches, pericarp, pulp, or stem. Preferably, it is an extract of fruit and / or leaves and / or seeds and / or pericarp and / or pulp. Even more preferably, it is an extract of seeds. For the purposes of this invention, "seed extract" means any extract of all or part of the N. lappaceum plant, including the seeds, advantageously consisting of the seeds only. Thus, in a preferred embodiment of the invention, the seed extract does not include the pericarp or the pulp. The seed extract is therefore not a fruit extract. Here, "pericarp" refers to the fruit's outer shell. The extract can be obtained by various extraction methods known to those skilled in the art, chosen from maceration, hot decoction, grinding including ultrasonic grinding, using a mixer, or the extract can be obtained by extraction in water under subcritical or supercritical conditions (carbon dioxide). Preferably, extraction is carried out by maceration. The extraction can be carried out from dry or fresh material, advantageously dry, in quantities of 0.1% to 30% by weight, advantageously from 1% to 20%, very advantageously from 5% to 20%, again advantageously from 20%, by weight relative to the total weight of the material and the extraction solvent. The extraction can be carried out at a temperature ranging from 4°C to 300°C. In a preferred embodiment of the invention, the extraction is carried out at a temperature of 4°C to 25°C, more preferably from 4°C to 20°C, and even more advantageously at ambient temperature, i.e., 20°C. In an alternative embodiment of the invention, the extraction is carried out at a temperature of 60°C to 90°C, preferably from 70°C to 85°C, and even more preferably at a temperature of 80°C. In another alternative embodiment of the invention, the extraction is carried out in water under subcritical conditions, at a temperature ranging from 100°C to 300°C, advantageously from 120°C to 250°C, and further advantageously at 120°C. The extraction can be carried out at a single given temperature or at successive increasing temperatures. In an advantageous embodiment of the invention, the extraction is carried out at a single temperature of 120°C. In an alternative embodiment, it is conducted along a gradient of three increasing temperatures between 100°C and 200°C, such as 120°C, 140°C then 160°C or 110°C, 130°C then 150°C, or even 120°C, 145°C then 170°C. Extraction under "subcritical conditions" means extraction in the presence of water, under temperature conditions above 100°C and pressure below 221 bars, such that the water remains in a liquid state but has a viscosity and surface tension lower than that of water at room temperature, increasing its dielectric constant. Thus, the extraction pressure is between 150 bars and 250 bars, preferably between 200 and 221 bars, advantageously in a pressure extraction autoclave. In another alternative embodiment of the invention, the extract is obtained by extraction under supercritical conditions (CO₂). Alternatively, the extract is obtained by extraction under supercritical conditions (CO₂) in the presence of a co-solvent. Advantageously, the co-solvent is ethanol. In yet another alternative embodiment, the extraction may be carried out in the presence of a Cs-Cy6 dialkyl carbonate solvent, as described in application WO2019020946 filed by the applicant. In this case, the extraction comprises incubating the extract according to the invention with a solvent comprising less than 50% by weight relative to the total weight of the solvent of at least one C5-Cy5 dialkyl carbonate, and the separation of the extract and / or extracted compounds contained in the extract according to the invention. Advantageously, said extraction comprises a step of immersing the extract according to the invention in a solvent comprising at least 50% by weight of at least one C5-Cys dialkyl carbonate; a step of extracting the mixture obtained; and a step of separating the extract and / or extracted compounds contained in the extract, comprising a step of centrifugation, filtration, evaporation, concentration, fractionation or purification or a combination of these steps.Advantageously, the solvent comprising at least 50% by weight relative to the total weight of the solvent of at least one C6-Cys dialkyl carbonate and the extract according to the invention are used with a weight ratio of between 1 and 100:1, between 2:1 and 100:1, or between 5:1 and 20:1, for example, a ratio of 10:1. Most advantageously, the C5-C5 dialkyl carbonate is a C7-C0 dialkyl carbonate, preferably C6-Cys. Alternatively, it is dioctyl carbonate or diethylhexyl carbonate, preferably dioctyl carbonate. In this alternative embodiment, the extraction step is carried out with or without agitation, with or without sonication, possibly under radiation (infrared, microwave), under pressure, or under atmospheric conditions. Thus, the extraction step can be assisted by microwaves and / or ultrasound. Advantageously, the extraction is carried out under atmospheric conditions. The extraction is carried out over a period of 30 minutes to 24 hours, preferably from 30 minutes to 12 hours, more preferably over a period of 1 hour to 5 hours, and most advantageously over a period of 1 hour to 2 hours. Most advantageously, the extraction is carried out over a period of 2 hours. The extract according to the invention is obtained by extraction in a solvent or mixture of solvents, preferably a protic polar solvent, and advantageously in water, an alcohol, a glycol, a polyol, a water / alcohol mixture, water / glycol or water / polyol (such as water mixed with ethanol, glycerol and / or butylene glycol and / or other glycols such as xylitol and / or propanediol, etc.) from 99 / 1 to 1 / 99 (w / w), advantageously in water as the sole solvent. In particular, the extract is obtained by aqueous extraction. For the purposes of the present invention, "extract obtained by aqueous extraction" means any extract obtained by extraction with an aqueous solution containing more than 60% by weight, advantageously at least 70% by weight, in particular at least 80% by weight, more particularly at least 90% by weight, particularly at least 95% by weight, of water relative to the total weight of the aqueous solution, even more advantageously not containing glycol and in particular not containing alcohol, more particularly particularly containing only water, In an alternative embodiment, the extract is an oil extract of N. lappaceum seeds. In this case, the extract is obtained in a particular way by extraction under supercritical conditions (COz) or by extraction in a C5-C,5 dialkyl carbonate type solvent. Or by extraction with heptane. In another alternative embodiment of the invention, the extraction is carried out in the presence of a nonionic surfactant, preferably selected from lauryl glucoside marketed under the name Plantacare® 1200UP by BASF or from caprylyl / capryl glucoside (Plantacare® 810 UP), preferably caprylyl / capryl glucoside (Plantacare® 810 UP). The weight concentration of the nonionic surfactant is between 0.5% and 5%, advantageously between 0.5% and 1%, and even more advantageously, 1% by weight relative to the total weight of the extract. In a first embodiment, the seed extract is obtained by macerating 20% ​​by weight of ground N. lappaceum seeds relative to the total weight of the solvent and seeds in water as the sole solvent, at a temperature of 20°C for a period of 2 hours. The crude extract is centrifuged, decanted, and then filtered (0.45 Jm) under the conditions described in Example 1a). In a second embodiment, the extract is obtained by macerating 20% ​​by weight of ground N. lappaceum seeds, relative to the total weight of the solvent and seeds, in water as the sole solvent, at a temperature of 20°C for a period of 2 hours. The crude extract is centrifuged, decanted, and then filtered. The extract is then spray-dried in the presence of maltodextrin, with a final quantity of maltodextrin of 80% by weight relative to the total weight of the final extract, under the conditions described in Example 1b). In a third embodiment, the extract is obtained by macerating 10% by weight of N. lappaceum seeds, relative to the total weight of the seeds and solvent, in an ethanol:water mixture (80:20; v / v) as solvent, at a temperature of 80°C for a period of 1 hour. The crude extract is centrifuged, decanted, and then filtered. The extract is spray-dried in the presence of maltodextrin, with a final quantity of maltodextrin of 80% by weight relative to the total weight of the final extract, under the conditions described in Example 1c). In a fourth embodiment, the extract is obtained by macerating 10% by weight of dried N. lappaceum pericarp in water as the sole solvent, relative to the total weight of pericarp and water, for a period of 1 hour at a temperature of 80°C. The resulting extract is decanted, centrifuged, and then the supernatant is filtered (Example 1d). In a fifth embodiment of the invention, the extract is obtained by maceration. in water as the sole solvent of a quantity of 10% by weight of N. lappaceum pulp, for a period of 1 hour at a temperature of 80°C. The crude extract was decanted, centrifuged and then filtered (Example the). In a 6th method, a quantity of 10% by weight of dried N. lappaceum leaves relative to the total weight of leaves and water as the sole solvent is macerated for a period of 1 hour at a temperature of 20°C. The extract obtained is decanted, centrifuged and then the supernatant is filtered (Example 1f). In a 7th mode, a quantity of 10% dried N. lappaceum seeds is extracted with CO, under supercritical conditions, in the presence of ethanol as co-solvent (10%), under the conditions described in Example 1g. The extract according to the invention is used alone or in a composition. When used alone as a cosmetic ingredient, it is preferably solubilized in an aqueous solution containing glycerin, advantageously present at a concentration of 60% to 90%, even more advantageously of 70% to 85%, very advantageously at a concentration of 80% by weight relative to the total weight of the aqueous solution comprising the extract. In an alternative embodiment of the invention, the extract is soluble and / or diluted in a solvent, particularly a polar solvent, such as water, an alcohol, a polyol, a glycol, such as pentylene glycol and / or butylene glycol and / or hexylene glycol and / or caprylyl glycol, or a mixture thereof, preferably a hydroglycolic mixture, more preferably containing a glycol selected from hexylene glycol, caprylyl glycol, and mixtures thereof. Advantageously, the extract obtained is diluted and / or soluble in an aqueous solution containing hexylene glycol, in particular containing between 0.1% and 10% by weight of hexylene glycol, preferably between 0.5% and 5% by weight of hexylene glycol, relative to the total weight of the cosmetic ingredient.Advantageously, the extract obtained is diluted and / or soluble in an aqueous solution containing caprylyl glycol, in particular containing between 0.01 and 5% by weight of caprylyl glycol, preferably between 0.1 and 1% by weight of caprylyl glycol, relative to the total weight of the aqueous solution comprising the extract. In particular, the aqueous solution in which the N. lappaceum extract according to the invention is solubilized comprises xanthan gum, in particular between 0.01 and 5% by weight of xanthan gum relative to the total weight of the aqueous solution, more particularly between 0.1 and 1% by weight of xanthan gum relative to the total weight of the aqueous solution comprising the extract. Advantageously, the solution in which the N. lappaceum extract according to the invention is solubilized comprises hexylene glycol, caprylyl glycol and xanthan gum. In another alternative embodiment, the liquid extract obtained according to the invention is atomized in the presence of maltodextrin, at a concentration of 70% by weight to 90% by weight relative to the total weight of the maltodextrin and the extract, advantageously from 75% to 85%, and further advantageously at a concentration of 80% by weight of maltodextrin relative to the total weight of the maltodextrin and the extract. The extract is in powder form. Another object concerns the use of an extract of N. lappaceum in a composition, advantageously a cosmetic composition, to prevent the appearance and / or reduce unpleasant odors, advantageously at the level of the skin and / or mucous membranes and / or skin appendages. In one embodiment of the invention, the extract of N. lappaceum is used in the composition in the form of a solution, aqueous or oily, rinse-off or not, an aqueous cream or gel or an oily gel, in particular a shower gel, a milk, an emulsion, a microemulsion or a nanoemulsion, in particular oil-in-water or water-in-oil or multiple or silicone, a mask, a serum, a lotion, a liquid soap, a dermatological bar, an ointment, a mousse, a patch, an anhydrous product, preferably liquid, pasty or solid, a hair care lotion, a deodorant, a spray, a toothpaste, a chewing gum, a mouthwash solution, a shampoo, a conditioner. The said composition can be applied topically or administered orally. In a preferred embodiment, the cosmetic composition comprises at least one cosmetically acceptable excipient. Thus advantageously, the extract according to the invention is present in the composition, advantageously cosmetic, at a concentration of 1x104% to 10%, preferably 1x10-*% to 5%, and even more preferably 1x10?% to 3% by weight, relative to the total weight of the composition. In a particularly advantageous embodiment of the invention, the extract of N. lappaceum is used in a cosmetic composition for hair, advantageously in the form of conditioner, hair care lotion, hair mask, or even more advantageously in the form of shampoo. The excipient(s) used in the cosmetic composition are selected from surfactants and / or emulsifiers, preservatives, buffering agents, chelating agents, denaturants, opacifying agents, pH adjusters, reducing agents, stabilizing agents, thickeners, gelling agents, film-forming polymers, fillers, mattifying agents, gloss enhancers, pigments, colorants, perfumes, and mixtures thereof. The CTFA (Cosmetic Ingredient Handbook, Second Edition (1992)) describes various cosmetic excipients suitable for use in the present invention. Advantageously, the excipient(s) are chosen from the group comprising polyglycerols, esters, polymers and cellulose derivatives, lanolin derivatives, phospholipids, lactoferrins, lactoperoxidases, sucrose-based stabilizers, vitamin E and its derivatives, xanthan gums, natural and synthetic waxes, vegetable oils, triglycerides, unsaponifiables, phytosterols, silicones, protein hydrolysates, betaines, aminoxides, plant extracts, sucrose esters, titanium dioxide, glycines, and parabens, and preferably from the group consisting of steareth-2, steareth-21, glycol-15 stearyl ether, cetearyl alcohol, phenoxyethanol, methylparaben, ethylparaben, propylparaben, butylparaben, butylene glycol, caprylyl glycol, natural tocopherols, glycerin, dihydroxycetyl sodium phosphate, isopropyl hydroxycetyl ether,glycol stearate, triisononanoine, octyl cocoate, polyacrylamide, isoparaffin, laureth-7, a carbomer, propylene glycol, hexylene glycol, glycerol, bisabolol, a dimethicone, sodium hydroxide, PEG-30 dipolyhydroxysterate, caprylic / capric triglycerides, cetearyl octanoate, dibutyl adipate, grapeseed oil, jojoba oil, magnesium sulfate, EDTA, a cyclomethicone, xanthan gum, citric acid, sodium lauryl sulfate, waxes and mineral oils, isostearyl isostearate, propylene glycol dipelargonate, propylene glycol isostearate, PEG-8, beeswax, Hydrogenated palm kernel oil glycerides, lanolin oil, sesame oil, cetyl lactate, lanolin alcohol, castor oil, titanium dioxide, lactose, sucrose, low-density polyethylene, isotonic saline solution, and mixtures thereof. The cosmetic composition may also include other ingredients having the same properties and inducing a synergistic or non-synergistic effect with the extract according to the invention, or ingredient agents with complementary effects. The extract can be combined with any other plant extract possessing similar properties of preventing the appearance and / or reducing unpleasant odors and / or any plant extract having the ability to mask said odors, such as an extract of mint, Mentha piperita, advantageously an extract of mint leaves, an extract of anise, an extract of Calendula officinalis, an extract of Commiphora myrrha, an extract of Camellia sinensis, Anthemis nobilis, Chamomilla recutita or Hordeum vulgare.The extract can also be combined with active plant extracts as an anti-pollution agent such as an extract of Argania spinosa marketed under the name ArganylTM by the applicant, and / or skin microbiota regulators such as an extract of Saccharomyces cerevisiae marketed under the name Re-lipidiumTM by the applicant, or phytosterols extracted from rapeseed oil marketed under the name PhytosootheTM by the applicant, or even a . protein extract from ungerminated Moringa oleifera seeds marketed under the name PurisoftTM by the applicant. Another object relates to the use of the extract of N. lappaceum according to the invention in the form of an active ingredient, in particular cosmetic, to prevent the appearance and / or reduce unpleasant odors, as defined in the present invention. In one embodiment, the extract according to the invention is used in a composition, advantageously a composition for domestic use, advantageously also a deodorizing composition. These compositions may be used in liquid and / or gel and / or spray form, advantageously as a spray, and may contain one or more other ingredients possessing the same properties and inducing a synergistic or non-synergistic effect with the extract according to the invention, and / or ingredients with complementary effects. In one embodiment, the extract according to the invention can be combined with any other plant extract having similar properties of preventing the appearance and / or reducing unpleasant odors and / or any plant extract having the ability to mask said odors, possibly in the form of an essential oil extract, such as an extract of mint, Mentha piperita, advantageously an extract of mint leaves, an extract of anise, an extract of Calendula officinalis, an extract of Commiphora myrrha, an extract of Camellia sinensis, Anthemis nobilis, Chamonmiilla recutita or Hordeum vulgare. A final object of the invention relates to a non-therapeutic, advantageously cosmetic, care method comprising the administration by topical or oral route, preferably the application by topical route, of the extract according to the invention or of a composition, advantageously cosmetic, comprising it, to prevent the appearance and / or reduce unpleasant odors, advantageously at the level of the skin and / or mucous membranes and / or skin appendages. In one embodiment of the invention, the cosmetic care process includes topical application to all or part of the body chosen from among the legs, feet, armpits, hands, thighs, belly, décolleté, neck, arms, torso, back, face, scalp, and / or mucous membranes and / or skin appendages, advantageously the hair. Alternatively, the treatment procedure will include the oral administration of a composition comprising N. lappaceum extract, advantageously in liquid or gel or chewing gum form to prevent the appearance and / or reduce unpleasant odors in the mucous membranes, advantageously the oral mucosa. Examples refer to the description of the invention and are presented below. These examples are given for illustrative purposes only and do not limit the scope of the invention. The examples form an integral part of the present invention and any feature which appears new compared with any prior art from the description taken as a whole, including the examples, forms an integral part of the invention. In the examples and unless otherwise stated, temperature is expressed in degrees Celsius and pressure is atmospheric pressure. Example 1: Methods of preparing the extract according to the invention The extracts prepared below are extracts of the Nephelium lappaceum plant from Vietnam. Example a) A quantity of 20% by weight of ground N. lappaceum seeds relative to the total weight of the solvent and seeds was obtained by maceration in water as solvent, at a temperature of 20°C for a period of 2 hours. The crude extract was centrifuged, decanted and then filtered. Example 1b) A quantity of 20% by weight of ground N. lappaceum seeds, relative to the total weight of the solvent and seeds, was obtained by maceration in water (the solvent) at a temperature of 20°C for a period of 2 hours. The crude extract was centrifuged, decanted, and then filtered. The extract was spray-dried in the presence of maltodextrin, with a final maltodextrin concentration of 80% by weight relative to the total weight of the final extract. Example Ic) A quantity of 10% by weight of ground N. lappaceum seeds, relative to the total weight of the solvent and seeds, was obtained by maceration in an ethanol:water mixture (80:20; v / v) as solvent, at a temperature of 80°C for a period of 1 hour. The crude extract was centrifuged, decanted, and then filtered. The extract was spray-dried in the presence of maltodextrin, with a final quantity of maltodextrin of 80% by weight relative to the total weight of the final extract. Example 1d): A quantity of 10% by weight of dried N. lappaceum pericarp, relative to the total weight of pericarp and water as the sole solvent, was extracted by maceration for a period of 1 hour at a temperature of 80°C. The extract obtained was decanted, centrifuged, and then the sump was filtered. Example 1) Extraction was carried out by maceration in water as the sole solvent using 10% by weight of N. lappaceum fruit pulp relative to the total weight of pulp and water, at a temperature of 80°C for a period of 1 hour. The crude extract was decanted, centriluped and then filtered. Example If) A quantity of 10% by weight of dried N. lappaceum leaves relative to the total weight of leaves and water as the sole solvent was extracted by maceration for a period of 1 hour at a temperature of 20°C. The extract obtained was decanted, centrifuged and then the supernatant was filtered. Example 1g) A quantity of 10% dried seeds was obtained by extraction at CO, under supercritical conditions, in the presence of ethanol as a co-solvent (10%). Example 2: Detection of volatile odor compounds by gas chromatography (GC-Toff SM) and descriptive olfactory sensory analysis (expert noses). Anti-odor effect of the extract according to the invention. [Protocol]: Calibrated Asian hair strands (2g / 12cm) were impregnated with an aqueous solution containing a final weight concentration of 0.02% seed extract (as described in example 1a) relative to the total weight of the composition, or with the same aqueous solution containing only distilled water (Control), at a ratio of 2mL per 2g of hair strands. These strands were then placed in a sealed urban pollution chamber as described in application WO2019020455 and exposed to exhaust fumes from a gasoline engine for 20 minutes of continuous operation. After the engine was switched off, the strands were left in contact with this polluted atmosphere for an additional 4 hours. The samples obtained after exposure were placed in polytetrafluoroethylene (PTFE) and polyethylene terephthalate (Nalophane™) bags to sample volatile compounds. The bags were filled with neutral air, and a portion of the contents was desorbed using a thermal desorption tube (Tenax®) for gas chromatography analysis. The volatile compounds were separated using a chromatographic column (Agilent 7890A) coupled to a mass spectrometer (BenchTOF-dx; ALMSCO). The results are shown in Table 1. The same experiment was repeated under identical conditions and revealed additional odorant compounds not detected during the 1st experiment (Table 2) (Only the additional odorant compounds are shown in Table 2). Protocol 2: The above protocol was replicated, and the volatile compounds desorbed onto Tenax® tubes were separated by gas chromatography and then analyzed at the column outlet by two expert noses using a sniffing module (Sensory Analysis). For each volatile compound analyzed, the experts described its intensity and odor (Table 3). Results : [Tables 2] Conclusion: Several volatile malodorous compounds were detected in trace amounts or their detected quantity decreased when hair strands were impregnated with a composition comprising the extract according to the invention, demonstrating the ability of said extract to reduce the adhesion and / or penetration of said compounds and / or to decrease the formation of these compounds by chemical reaction. The extract according to the invention therefore has an effect on preventing the appearance and / or reducing unpleasant odors, particularly on the skin and / or mucous membranes and / or skin appendages. [Tables 3] Scale from 0 to 5. A value of "0" indicates that the volatile compound of interest is not detected. The maximum value of "5" corresponds to a very high intensity. Conclusion: The olfactory sensory analysis of the desorbed samples separated by gas chromatography showed a decrease in the odor intensity of four compounds that could be perceived as malodorous. Protocol: Calibrated strands of Asian hair (1 g / 12 cm) were homogeneously impregnated with an aqueous solution containing a final weight concentration of 0.02% of seed extract prepared according to example (a) relative to the total weight of the composition, or containing only distilled water (Control). The strands were then placed in a sealed pollution chamber and exposed to exhaust gases for 90 minutes. A panel of 30 volunteers aged 20 to 45, considered qualified (i.e., trained to perceive odors), randomly rated the intensity of odors on a scale of 1 to 9, with 1 being the weakest and 9 the strongest. The odors were classified into three grades: weak (1), medium (2), and strong (3). The results are expressed as the mean of the grade values ​​using the Wilcoxon test. Values ​​were considered significant for p < 0.05 (Table 4). Results: [Tables 4] Conclusion: The average perceived odor level of the odor in the panel of 30 volunteers decreased when the hair strands were impregnated with the composition containing the extract according to the invention. Therefore, the N. lappaceum extract has the ability to reduce unpleasant odors in hair after exposure to exhaust fumes. Example 4. Example of a cosmetic ingredient including N. lappaceum extract. Extract of N. lappaceum Ex. 1a) to 1f) 20% by total weight Maltodextrins 80% by total weight Example 5; Examples of cosmetic compositions comprising the extract according to the invention Example Sa): Cosmetic formulations for the body The composition below is prepared according to methods known to those skilled in the art, particularly with regard to the different phases to be mixed together. The quantities indicated are percentages by weight relative to the total weight of the composition. Phase Name Quantity (% by total weight) At 94.75°C A Preservative qsp 100 Glycerin 1.00 B Xanthan gum 0.2 B Sodium polyacrylate 0.25 C Cosmetic ingredient according to example 4 1-5 E 5b): F |. 4

Claims

Demands

1. - Non-therapeutic use of an extract of Nephelium lappaceum to prevent the appearance and / or reduce unpleasant odors in skin and / or mucous membrane and / or skin appendage level.

2. - Use according to claim | characterized in that the extract of N. lappaceum is an extract of fruit and / or seeds and / or leaves and / or of pericarp and / or pulp.

3. - Use according to claim | characterized in that the extract of N. lappaceum is a seed extract.

4. - Use according to any one of claims 1 to 3 ca- characterized in that the extract of N. lappaceum is obtained by extraction in a solvent or mixture of solvents, preferably a polar solvent protic, and advantageously in water, an alcohol, a glycol, a polyol, a water / alcohol, water / glycol or water / polyol mixture (such as water in mixture with ethanol, glycerol and / or butylene glycol and / or other glycols such as xylitol and / or propanediol, etc.) from 99:1 to 1:99 (w / w).

5. - Use according to any one of claims 1 to 4 ca- characterized in that the extract of N. lappaceum is obtained by extraction in water as the sole solvent.

6. - Use according to any one of claims 1 to 5 ca- characterized by its cosmetic use.

7. - Use according to any one of claims 1 to 6 ca- characterized in that the extract of N. lappaceum is included in a cosmetic composition comprising at least one cosmetic excipient ticatically acceptable, in concentrations of 0.0001% to 10%, advantageously- slightly from 0.001% to 5%, by weight relative to the total weight of the cosmetic composition.

8. - Use according to any one of claims 1 to 7 ca- characterized in that the extract of N. lappaceum or the composition including whether applied topically or administered orally, preferably via topical application.

9. - Use according to any one of claims 1 to 8 for prevent the appearance and / or reduce unpleasant odors at the level hair.

10. - Use according to any one of claims 7 to 9 ca- characterized in that the composition is chosen from a solution, aqueous or oily, a cream or gel, aqueous or oily, including a shower gel, a lotion, an emulsion, a microemulsion or a nanoemulsion, in particular oil-in-water or water-in-oil or multiple or silicone-based, a mask, a serum, a lotion, a soap liquid, dermatological soap, ointment, mousse, patch, an anhydrous product, preferably liquid, paste or solid, a lotion hair care products, deodorant, chewing gum, toothpaste, a shampoo.

11. - Use of the extract of N. lappaceum as defined in one any of the claims | to 5 in the form of an active ingredient in a composition for domestic use, particularly as a deodorizer to prevent the occurrence and / or reduce unpleasant odors.

12. | - Use according to any one of claims 1 to 11 such as N. lappaceum extract prevents the appearance and / or reduces the amount of at least one malodorous volatile compound chosen from the ben- zaldehyde, acetone, 4,6,8-trimethyl-1-nonene, (E)-2-dodecene, decane, methacrolein, indene, butylcyclohexyl- 1,2-benzenedicarboxylic ester, benzene, toluene, ethylbenzene, styrene, propylbenzene, 1-ethyl,-3-methylbenzene or the 3-Ethyltoluene, advantageously, benzaldehyde, benzene, the toluene, ethylbenzene, styrene, propylbenzene, the 1-Ethyl,-3-methylbenzene or 3-ethyltoluene, even more advanced- benzaldehyde is very potent.

13. - A non-therapeutic, advantageously cosmetic, treatment method including the topical or oral administration of an extract of N. lappaceum or a composition containing it to prevent the appearance and / or reduction of unpleasant odors on the skin and / or mucous membranes and / or skin appendages.

14. - Process of care according to claim 13 such as the extract of N. lappaceum is as defined in any one of claims 1 as5.

15. - A treatment method according to any one of claims 13 or 14 characterized in that it includes the application of the extract of N. lappaceum or a composition containing it, applied topically to all or part of the body chosen from the legs, feet, armpits, hands, thighs, stomach, décolletage, neck, arms, torso, the back, face, scalp, and / or mucous membranes and / or appendages skin, advantageously the hair.