Combination for the treatment of halitosis

Abstract

The present invention relates to a combination for the treatment of halitosis and to the non-therapeutic use of a sprayable composition comprising a green tea extract and parsley essential oil, for the treatment of halitosis. The present invention also relates to a sprayable composition comprising a green tea extract and parsley essential oil for use as a medicament in the treatment of halitosis. The present invention finds application in particular in the fields of oral and dental treatments. The combination for the treatment of halitosis comprises a sprayable composition comprising a green tea extract and parsley essential oil, said composition being in a spray, and a composition in the form of a lozenge comprising a green tea extract and parsley essential oil.

Description

Title of the invention: Combination for the treatment of halitosis Technical field of the invention

[0001] The present invention relates to a combination for the treatment of halitosis and to the non-therapeutic use of a sprayable composition comprising a green tea extract and parsley essential oil and a lozenge composition comprising a green tea extract and parsley essential oil, for the treatment of halitosis. The present invention also relates to a sprayable composition comprising a green tea extract and parsley essential oil and a lozenge composition comprising a green tea extract and parsley essential oil, for the treatment of halitosis for use as a medicament in the treatment of halitosis.

[0002] The present invention finds application in particular in the fields of oral and dental treatments. Prior art

[0003] Bad breath or halitosis is an unpleasant odor, likely to bother people, of the air that we exhale through the mouth and nose. This odor can correspond, for example, to the smell of eggs, rotten cabbage or fish, rotten apples, etc. Bad breath or halitosis can be temporary and / or long-lasting.

[0004] The origin of halitosis is oral in 85% of cases. The most common causes include gum disorders, periodontal disease, smoking and / or ingested food that contains a volatile compound. Gastrointestinal disorders rarely cause halitosis due to the closure of the esophagus. Certain bacteria such as Porphyromonas, Prevotella, Fusobacterium present on dental surfaces, in periodontal pockets, on the dorsal part of the tongue, in the presence of food debris of amino acids, and depending on the pH release volatile compounds carried out by exhaled air. These volatile compounds have a strong odor, very unpleasant at extremely low concentrations. They are essentially sulfur derivatives and amino derivatives. Among the sulfur derivatives are mainly present: hydrogen sulfide H2S, methyl mercaptan CH3SH, di-methyl mercaptan (CH3)2S.They are detectable by a human nose at very low concentrations.

[0005] Known treatments for halitosis include improving oral hygiene, for example through more regular tooth brushing and brushing the tongue. The use of oral antiseptic compositions is also known to reduce and / or eliminate possible bacteria responsible for halitosis. However, the effectiveness of these compositions remains limited.

[0006] Among the known treatments, the use of compounds and / or lozenges, for example chewing pastes and / or chewing gum, flavored with aromas, in particular menthol aromas, possibly make it possible to temporarily mask bad odors.

[0007] Another known treatment relates to the use of molecules or complex extracts, for example zinc salts, for example chlorides or lactates, green tea extracts and / or essential oils reacting with sulfur compounds such as hydrogen sulfide H2S, methyl mercaptan CH3SH, dimethyl-mercaptan (CH3)2S in order to reduce their volatility. However, the effectiveness, in particular the reduction of bad odor and / or the longevity of effect are relative and the administration of said molecules or said complex extracts must be frequently repeated.

[0008] Also, there is a need in the state of the art to find means allowing an improvement in the effective and lasting treatment of halitosis, allowing a reduction of bad odors up to their elimination. Statement of the invention

[0009] The present invention aims precisely to meet these needs by providing a combination intended for the treatment of halitosis, said combination comprising: - a sprayable composition comprising a green tea extract and parsley essential oil, said composition being in a sprayer, and - a composition in the form of a lozenge comprising a green tea extract and parsley essential oil.

[0010] By green tea extract, it may be for example an aqueous or oily extract or an organic extract or a mixture of these extracts. It may be for example an essential oil, for example organic, for example from organic farming. It may be a green tea extract obtained from all or part of the plant, for example the aerial parts of the plant, for example leaves, stems, flowers or a mixture of these. It may be for example an extract of camellia sinensis, preferably an extract of camellia sinensis leaves.

[0011] Whatever the nature of the green tea extract, it can be obtained by any of the techniques known to those skilled in the art, for example by hydroalcoholic extraction or by steam distillation.

[0012] Herein, parsley essential oil may be any parsley essential oil known to those skilled in the art and / or commercially available. It may be, for example, an essential oil obtained from all or part of the parsley plant, for example, the aerial parts of the plant, for example, leaves, stems, flowers, or a mixture thereof. It may be, for example, an essential oil of petroselinum crispum, preferably from the leaves of petroselinum crispum.

[0013] Parsley essential oil can be obtained by any of the techniques known to those skilled in the art, for example by hydrodistillation or using an extraction fluid, preferably in the supercritical or near supercritical state.

[0014] In the present invention, the term sprayable composition means a composition which can be sprayed in fine droplets. The composition is such that it allows droplets to be formed, for example having an average diameter of 150 to 800 μm, preferably 200 to 600 μm. A person skilled in the art will know how to choose a suitable spray nozzle, preferably oral, for spraying the composition of the present invention. Examples of compositions are presented below. An example of a sprayer is also presented below. The sprayable composition is preferably an aqueous solution comprising a green tea extract and a parsley essential oil.

[0015] The amount of green tea extract in the sprayable composition may be, for example, from 0.01 to 3% by weight relative to the total weight of the composition, preferably from 0.03% to 2.5%, preferably from 0.01% to 0.1%, preferably from 0.03 to 0.05%, preferably from 0.04% to 2.5%, preferably from 0.05% to 2.5%, preferably from 0.5 to 2% by weight relative to the total weight of the sprayable composition.

[0016] The amount of parsley essential oil in the sprayable composition may for example be from 0.01% to 5% by weight relative to the total weight of each composition, preferably from 0.01% to 1%, preferably from 0.05% to 1%, preferably from 0.06% to 1%, preferably from 0.1% to 1%, preferably from 0.01 to 0.2% by weight relative to the total weight of the sprayable composition.

[0017] The sprayable composition may further comprise one, several or the following elements, the quantity of which is expressed in % by weight relative to the total weight of the composition: - water, generally qsp 100%, - a non-ionic surfactant, for example PEG-40 hydrogenated castor oil, for example at a rate of 2 to 10%; - an antiseptic, for example a cationic antiseptic, for example belonging to the class of quaternary ammoniums, for example cetylpyridinium chloride, for example at a rate of 0.01 to 0.2%, - an anti-caking agent, for example disodium phosphate, for example at a rate of 0.1 to 1%, - a flavoring, for example fresh mint, green tea or citrus, at a rate of 0.1 to 1%, - an antioxidant or acidity regulator, for example potassium phosphate, at a rate of 0.2 to 2%, and - a sweetening agent and / or a sweetener, natural or artificial, preferably a sweetener, for example glucose, fructose, sucralose or xylitol or a mixture thereof, preferably sucralose and / or xylitol, each of the sweetening agents and / or sweeteners being used in the composition in an amount of 0.01 to 2%.

[0018] The sprayable solution can be prepared by simply mixing the different ingredients. The mixing is preferably sufficient to avoid agglomerates or suspensions and to obtain a homogeneous sprayable composition.

[0019] By way of non-limiting example, the sprayable composition may comprise water, polyethylene glycol 40 (PEG-40), hydrogenated castor oil, Camellia sinensis leaf extract, cetylpyridinium chloride, disodium phosphate, a flavoring agent (aroma), glycerin, limonene, linalool, Petroselinum crispum (parsley) essential oil, potassium phosphate, sucralose and xylitol.

[0020] By way of non-limiting example, the sprayable composition may comprise water, polyethylene glycol 40 (PEG-40), hydrogenated castor oil, Camellia sinensis leaf extract, cetylpyridinium chloride, disodium phosphate, a flavoring (aroma) agent, Petroselinum crispum (parsley) essential oil, potassium phosphate, sucralose, and xylitol.

[0021] In the present invention, by composition in the form of a lozenge is meant a solid galenic form intended to be sucked and to disintegrate and / or dissolve in the mouth, in order to exert its action in the oral cavity. The composition is such that it allows lozenges to be formed. It may be, for example, cylindrical, round, square, diamond-shaped, or other, for example, flattened and rounded square, tablet or lozenge, or granules. The dimensions, for example the diameter and / or the side, of the lozenge are suitable for oral administration; it may be, for example, a dimension of 0.5 to 1.5 cm in diameter.

[0022] The amount of green tea extract in the composition in the form of a lozenge may be, for example, from 0.01 to 3% by weight relative to the total weight of the composition, preferably from 0.03% to 2.5%, preferably from 0.01% to 0.1%, preferably from 0.03 to 0.08%, preferably from 0.03 to 0.05%, preferably from 0.04% to 2.5%, preferably from 0.05% to 2.5%, preferably from 0.08%, preferably from 0.5 to 2% by weight relative to the total weight of the composition in the form of a lozenge.

[0023] The quantity of parsley essential oil in the composition in the form of a lozenge may for example be from 0.01% to 5% by weight relative to the total weight of each composition, preferably from 0.01% to 1%, preferably from 0.05% to 1%, preferably from 0.06% to 1%, preferably from 0.1% to 1%, preferably from 0.01 to 0.2%, preferably from 0.03% to 0.07%, preferably 0.04% by weight relative to the total weight of the composition in tablet form.

[0024] The composition in the form of a tablet may further comprise one, several or the following elements, the quantity of which is expressed in % by weight relative to the total weight of the composition in the form of a tablet: - a filler or binder, for example isomalt, for example sieved, generally qsp 100%, - an acidifier, for example citric acid, for example at a rate of 0.01 to 1%, - a colouring additive, for example sodium copper chlorophyllin, for example at a rate of 0.001 to 0.1%, - a flavoring, for example fresh mint, green tea or citrus, at a rate of 0.1 to 1%, and - a sweetening agent and / or a sweetener, natural or artificial, preferably a sweetener, for example acesulfame potassium, glucose, fructose, sucralose or xylitol or a mixture thereof, preferably sucralose and / or xylitol and / or acesulfame potassium, each of the sweetening agents and / or sweeteners being used in the composition in an amount of 0.05 to 1%.

[0025] By way of non-limiting example, the composition in lozenge form may comprise isomalt, Camellia sinensis leaf extract, a flavoring agent (aroma), acesulfame potassium, Petroselinum crispum (parsley) essential oil, citric acid and sodium copper chlorophyllin.

[0026] To manufacture the composition in the form of a tablet, a paste containing the different ingredients is prepared, for example hot in order to fluidify the binder, then the paste is introduced into a mold which gives it its final shape.

[0027] In the present invention, independently in the sprayable composition and / or in the composition in the form of a tablet, the mass ratio of green tea extract / parsley essential oil may be from 1 / 5 to 1 / 30, preferably 1 / 15.

[0028] In the present, one and / or the other of the compositions may further comprise in percentage by weight relative to the total weight of each composition: - 50 to 80% of at least one glycerol ester of a fatty acid, preferably C6 to C12, preferably C8 and C10, saturated and linear, alone or as a mixture, and / or - 9 to 11% gelatin, and / or - excipients in sufficient quantity to constitute the sprayable composition or the composition in tablet form.

[0029] The present invention also relates to a non-therapeutic method of treating halitosis comprising the oral administration of a combination as defined herein.

[0030] The present invention also relates to the non-therapeutic use of a sprayable composition comprising a green tea extract and parsley essential oil, characterized in that the sprayable composition is administered by oral spray concomitantly or successively with a composition in the form of a lozenge comprising a green tea extract and parsley essential oil for the treatment of halitosis.

[0031] The present invention also relates to a sprayable composition comprising a green tea extract and parsley essential oil for its use as a medicament in the treatment of halitosis, characterized in that it is administered by oral spray concomitantly or successively with a composition in the form of a lozenge comprising a green tea extract and parsley essential oil.

[0032] The present invention also relates to a kit intended for the treatment of halitosis, therapeutic or non-therapeutic, comprising: - a sprayable composition comprising a green tea extract and parsley essential oil, said composition being in a sprayer, and - a composition in the form of a lozenge comprising a green tea extract and parsley essential oil.

[0033] The sprayable composition comprising a green tea extract and parsley essential oil is as defined above.

[0034] The composition in the form of a lozenge comprising a green tea extract and parsley essential oil is as defined above.

[0035] Even if in the present description reference is made to a kit or a combination, it is understood that each of the compositions of the kit can be administered concomitantly or successively, for example independent administration of the sprayable composition and independent administration of the composition in the form of a lozenge, these administrations being carried out on the same individual. These different administrations can be carried out, independently of one another or in a linked manner, one or more times per day, for one or more successive weeks or not.

[0036] Whether it is the combination, the method, the non-therapeutic use or the therapeutic use, or the kit, the sprayable composition comprising a green tea extract and parsley essential oil and the composition in the form of a lozenge comprising a green tea extract and parsley essential oil are as defined herein.

[0037] Other advantages may still become apparent to those skilled in the art upon reading the examples below, given for illustrative purposes. Examples

[0038] The studies presented in the examples below were carried out in accordance with the ISO 20252 standard, Regulations of the European Commission (EU) No 655 / 2013 and ASTM E1958-16a.

[0039] Example 1: Effect of combinations according to the invention in the treatment of halitosis

[0040] The study of the effect of a combination according to the invention was carried out by users of products known in the treatment of halitosis. In this study, examples of combinations according to the invention and comparative examples were tested against bad breath.

[0041] The users in this example were selected from three different locations in France: the cities of Nantes, Cergy and Lille.

[0042] There were seventy-one (71) users, 69% female and 31% male. The average age was 44 years. Table I describes the age distribution of the population.

[0043] Table 1: Distribution of the population studied during the test according to age

[0044] [Tables 1] Age group 25-35 years 36-50 years 51-70 years Proportion in the population (in %) 18% 55% 27%

[0045] All selected users met the following criteria: - have problems with bad breath / halitosis, - Use at least one product to combat / treat this bad breath / halitosis, - have a life as a couple with close friends and family (“partners”), - are in active life, and - have purchased a dental product in a pharmacy or drugstore in the last 6 months.

[0046] Users meeting all of the conditions mentioned above were selected. The products were compositions in the form of tablets and sprayable compositions. All the products tested were applied repeatedly by the user. In the case of a combination according to the invention, the sprayable composition and the composition in the form of a tablet were administered concomitantly or successively.

[0047] Sprayable compositions used for the entire duration of the test are described in the following Table 2.

[0048] Table 2: Details of the sprayable compositions tested (in % by weight relative to the total weight of the composition)

[0049] [Tables2] Components Concentration / quantity in % by weight relative to the total weight of the composition Water Qsp 100 PEG-40 hydrogenated castor oil 2-10 Cetylpyridinium chloride 0.01 to 0.2 Disodium phosphate 0.1 to 1 Aroma 0.1 to 1 Camellia sinensis leaf extract 0.5 to 2 Petroselinum crispum leaf oil 0.01 to 0.2 Potassium phosphate 0.2 to 2 Sucralose, 0.01 to 2 Xylitol 0.01 to 2

[0050] The compositions in the form of pellets used in the present example are described in Table 3 below. Each pellet has a mass of 2.5 grams.

[0051] Table 3: Details of the compositions in pellet form tested (in % by weight relative to the total weight of the composition)

[0052] [Tables3] Components Concentration / quantity in % by weight relative to the total weight of the composition Isomalt Qsp 100 Green tea extract 0.5 to 2 Flavoring 0.1 to 1 Sweetener: acesulfame potassium 0.05 to 1 Parsley essential oil 0.01 to 0.2 Acidifier: Citric acid 0.01 to 1 Color additive: sodium copper chlorophyllin 0.001 to 0.1

[0053] Protocol for administering the composition in the form of a tablet and / or the sprayable composition.

[0054] During the first week, 71 individuals tested sprayable compositions and 71 individuals tested compositions in tablet form.

[0055] During the second week, the 71 people who had tested the composition in tablet form during the first week, tested the sprayable composition in combination with the composition in tablet form.

[0056] An assessment of breath odor was performed by the individuals' partners.

[0057] For both weeks, partner and user data were collected for the assessment of the level without treatment (before first use), 1 (D+1, after first use) and 7 (D+7, after several uses). RESULTS

[0058] The following parameters were evaluated: overall satisfaction with the combination, evolution of breath over time, comfort level, confidence level with respect to the breath, time of action / effect, appreciation of the combination, appreciation of the breath by an external third party, description of the breath.

[0059] A determination of the various advantages / beneficial effects, in particular on breath, improvement of social behavior through the use of the combination was also carried out. A determination of the well-being of the users was also carried out.

[0060] Tables 4 to 17 below present the various results obtained. In particular, the results obtained include in particular a comparison between the use of the composition in the form of a tablet alone and the use of examples of the combination according to the invention.

[0061] Table 4: Overall satisfaction of users who tested the composition in the form of lozenge and those who tested the combination of compositions.

[0062] [Tables4] Overall satisfaction using only the composition in tablet form (average out of 10 and % of T5B) Overall satisfaction using only the sprayable composition (average out of 10 and % of T5B) Overall satisfaction using the combination according to the invention (average out of 10 and % of T5B) D+1 7.28 / 10 89% 7.38 / 10 90% 8.37 / 10 97%

[0063] In the table below T5B means the percentage of scores from 6 to 10.

[0064] As demonstrated in Table 4 above, from the first day of use, examples of the combination according to the invention achieve a satisfaction rate higher than that of the tablet alone or the sprayable composition. These results demonstrate therefore clearly that the combination according to the invention advantageously makes it possible to obtain an unexpected synergistic effect superior to the sole use of the composition in the form of a lozenge.

[0065] Table 5: Evolution of the perception of the breath of users and their partner: use alone of the composition in the form of a lozenge versus use of the combination according to the invention

[0066] [Tables5] Use of the composition in spray form alone (% improvement) Use of the composition in lozenge form alone (% improvement) Use of the combinations according to the invention (% improvement) Time D+7 D+7 D+7 Partner's point of view 93% 94% 99% User's point of view 93% 94% 97%

[0067] As demonstrated in Table 5, the use of the combination according to the invention advantageously and surprisingly and significantly improves the breath of users from the first use, compared to the use of the composition alone in the form of a tablet or the sprayable composition.

[0068] Table 6: Level of comfort of users with their breath after using the combination according to the invention

[0069] [Tableauxô] User's point of view Partner's point of view Without treatment D+1 D+7 Without treatment D+1 D+7 Average (out of 10) 4.73 7.01 8.21 4.11 6.62 8.13 T5B (% marks from 6 to 10) 35% 70% 86% 27% 72% 92% T4B (% marks from 7 to 10) 18% 63% 86% 14% 59% 85%

[0070] In the table below T5B means the percentage of marks between 6 and 10, T4B means the percentage of marks between 7 and 10.

[0071] As demonstrated in Table 6, from the first day of use of the combination according to the invention, the user's level of comfort with respect to his breath was significantly higher and was further increased after 7 days of use, from the point of view of the 71 users as well as from the point of view of the 71 partners.

[0072] Table 7: User confidence level in breath

[0073] [Tables7] Use of the composition in tablet form alone (average) Use of the sprayable composition alone (average) Use of the combination according to the invention (average) Time D+1 D+7 D+1 D+7 D+1 D+7 Level of confidence in their breath (user point of view) 6.99 7.79 7.04 8.11 8.42 8.46 Level of comfort with their breath (user point of view) 6.56 7.35 6.44 7.21 6.62 8.13

[0074] As demonstrated in Table 7 from the first day of use, users regained an excellent level of confidence in their breath, from the point of view of the 71 users as well as from the point of view of the 71 partners. The results obtained clearly demonstrate that the use of the combination according to the invention advantageously allows an increase in the level of confidence compared to the use alone of the composition in the form of a tablet or the sprayable composition.

[0075] Table 8: Effect of the combination according to the invention on breath Time D+7 YES NO Improvement of the “healthy breath” effect of the composition in lozenge form thanks to the sprayable composition 94% 6% Beneficial effect on the breath of the combination 96% 4% Purchase intention 94% 6%

[0077] As demonstrated in Table 8, users have noted that the combination according to the invention advantageously allows a significant improvement, in particular of the “healthy breath” effect obtained.

[0078] Table 9: Evaluation of the action time of the combination according to the invention by report to the composition in the form of a lozenge

[0079] [Tables9] Use of the composition alone in the form of a lozenge (% rapid) Use of the combination according to the invention (% rapid) D+1 D+7 D+1 D+7 49% 58% 68% 73%

[0080] As demonstrated in Table 9, the combination according to the invention advantageously makes it possible to obtain an effect in a reduced time compared to the composition in lozenge form. In other words, the combination according to the invention advantageously and surprisingly makes it possible to treat halitosis more quickly compared to the use of the composition in lozenge form alone.

[0081] Table 10: Product assessment by users of the combination according to the invention

[0082] [TableauxlO] Use of the combination according to the invention (D+D) Advice for use / dosage (D+l) Product assessment? (average out of 10) 8.3 8

[0083] As demonstrated in Table 10, the example combination according to the invention was highly appreciated by users.

[0084] Table 11: Assessment of the user's breath by his partner, after use of the combination according to the invention

[0085] [Tableauxll] Time Without treatment D+1 D+7 Average out of 10 5.14 8.28 8.70 T5B (% marks from 6 to 10) very pleasant 45% 92% 96% T4B (% marks from 7 to 10) very pleasant 24% 90% 94%

[0086] As demonstrated in Table 11, the use of the combination according to the invention advantageously and surprisingly allows, from the first day of use, a significant treatment of halitosis / bad breath, advantageously allowing the obtaining of significantly more pleasant breath for the partner. In addition, the results obtained demonstrate that this effect is sustainable over time and was further increased at 7 days. In addition, the results clearly demonstrate an appreciation of the breath by the partner.

[0087] Table 12: Description of the user's breath depending on the use of the combination according to the invention Intensity of parameters (average out of 10) Character of breath Use of the sprayable composition alone (average) Use of the composition in lozenge form alone (average) Use of the combination according to the invention (average) T14 / 15 Without treatment D+1 D+7 Without treatment D+1 D+7 Without treatment D+1 D+7 Freshness 3.42 7.03 7.96 1.96 6.96 7.51 1.96 7.87 7.83 Acidity 4.75 2.51 2.18 4.69 2.06 1.63 4.69 1.10 1.03 Bitterness 4.92 2.31 1.99 5.00 2.17 1.56 5.00 1.28 1.08 Bad odor 6.94 2.97 2.51 7.24 2.97 2.10 7.24 1.38 1.38 Dry mouth 5.90 2.87 2.65 6.00 2.59 2.11 6.00 1.39 1.48 Pasty mouth 6.11 2.89 2.00 6.61 2.56 1.72 6.61 1.31 1.08 Metallic taste 3.65 1.83 1.82 3.03 1.27 1.15 3.03 0.76 0.62 Bad taste in mouth 5.89 2.94 2.46 6.65 2.66 1.89 6.65 1.58 1.35 Astringency 3.38 2.86 2.48 3.56 2.15 1.86 3.56 1.41 1.04 Dry tongue 4.52 2.68 2.31 4.31 2.14 2.00 4.31 1.35 1.11

[0089] As demonstrated in Table 12, the use of the combination according to the invention advantageously and surprisingly allows, from the first day of use, a significant and synergistic improvement in freshness, a reduction in bad odor, dry mouth, pasty mouth, metallic taste, bad taste in the mouth, astringency, and dry tongue compared to the use alone of the composition in the form of a lozenge or the pulverized composition. verifiable. Furthermore, the results obtained demonstrate that this effect is sustainable over time.

[0090] In particular, users of the combination according to the invention have significantly and advantageously regained fresh breath (85% at D+7).

[0091] Users found that the product combination provides freshness in the mouth, were satisfied with the combination which increased their confidence level in their breath. They concluded that the combination increases the effectiveness of the products.

[0092] Table 13: Evaluation of the improvement in the user's social behavior after a first use and after several uses of the combination according to the invention Use of the sprayable composition alone (average) Use of the composition in tablet form alone (average) Use of the combination according to the invention (average) Without treatment D+1 D+7 Without treatment D+1 D+7 Without treatment D+1 D+7 I lack self-confidence 6.08 4.55 3.62 6.17 4.31 3.15 6.17 2.73 1.86 I adjust my posture when I interact socially outside my home 6.72 4.97 3.87 7.72 5.07 3.70 7.72 3.31 2.51 I adjust my posture when I interact socially inside my home 6.06 4.75 3.62 6.48 4.61 3.38 6.48 2.90 2.00 I keep my distance during group activities 6.08 4.55 3.41 6.41 4.42 3.31 6.41 2.65 1.85 I am not 6.13 4.59 3.30 6.11 4.01 3.08 6.11 2.54 1.83 not comfortable with my colleagues I am not comfortable in intimacy 6.07 4.39 2.99 5.69 3.96 2.61 5.69 2.73 1.85 I feel embarrassed 5.89 4.37 3.15 6.41 4.37 2.85 6.41 3.00 1.70

[0094] As demonstrated in Table 13, the use of the combination according to the invention advantageously allows, in a surprising and synergistic manner, from the first day of use, a significant improvement in confidence, a reduction in discomfort in their social life due to the breath of the users. In addition, the results obtained clearly demonstrate a significant improvement in the results compared to the use alone of the composition in the form of a tablet or the use alone of the sprayable composition.

[0095] Table 14: Evaluation of the benefits for breath after using the composition in lozenge form or after using the combination according to the invention Use of the sprayable composition alone (average) Use of the composition in lozenge form alone (average) Use of the combination according to the invention (average) D+1 D+7 D+1 D+7 D+1 D+7 My breath is purified 6.70 7.58 6.66 7.01 7.86 8.32 My breath is fresh 7.03 7.93 7.20 7.52 8.35 8.65 My breath is impeccable - - - 6.38 - 7.66 I feel protected against bad breath 6.72 7.14 6.58 7.17 7.93 8.31 This product improves my daily life 6.93 7.80 6.93 7.69 7.79 8.52

[0097] As demonstrated in Table 14, the use of the combination according to the invention advantageously and surprisingly allows, from the first day of use, a significant improvement in the breath of the users compared to the use of the composition alone in the form of a lozenge or the use of the sprayable composition alone. In addition, the results obtained demonstrate that this effect is lasting over time.

[0098] Table 15: Partners' evaluation of the overall improvement in the breath of users of the combination according to the invention after one week of testing Partner Statement TRUE FALSE User's breath is more pleasant 96% 4% User's breath improved 99% 1% I am not bothered by the user's breath 86% 14% Users seem confident in their breath 96% 4% Users no longer seem bothered 92% 8%

[0100]

[0101]

[0102]

[0103] As demonstrated in Table 15, the use of the combination according to the invention advantageously and surprisingly allows a treatment of Thalitosis / bad breath confirmed significantly by the users' partners seeing an improvement in the users' breath. B / In addition, an assessment of the well-being of users of the combination according to the invention was carried out. The well-being of the users was evaluated after one week of use (D+7) of the combination according to the invention. The users corresponded to those mentioned above. Well-being was defined by 9 dimensions / parameters: 1. Health: General state of physical or mental health (including fatigue, sleep, energy, memory) 2. Self: Self-esteem, self-confidence, emotional / psychological state, control over one's personal life and belief in one's own opinion. 3. Living environment: personal environment (living space, transportation, healthy and safe daily life) 4. Social relationships: relationships with other people 5. Overall life satisfaction: general quality of life, ability to enjoy life in general 6. Moral Values: Being true to one's own values, beliefs, personal commitments and life goals. 7. Daily: Carrying out daily personal or professional tasks, making the most of one's free time / hobbies 8. Intellectual situation: intellectual stimulation, improvement of intellectual capacities 9. Economic situation: possibility of purchasing a product and a potential sa- satisfaction in the case of a purchase 10. Daily 11. Intellectual situation 12. Economic situation

[0104] Each dimension / parameter had its own weight in the overall measurement of "well-being". In the method that was used, the importance of each dimension was relative to the number of questions asked per dimension / parameter.

[0105] Questions were asked to each user after several days of use of the combination according to the invention (D+7). The user had to respond from multiple answers, arranged on a 5-point scale. The first 4 levels range from total disagreement (answer 1) to maximum approval (answer 4). The last level (answer 5) allows the user to highlight a lack of relevance between the question and the effects of the targeted product.

[0106] It was verified that users were not disturbed or influenced by significant events during the duration of the research study. The results are described in Table 16 below.

[0107] Table 16: impact of a significant external event on the lives of users during the test period

[0108] [Tableauxlô] Impact of a significant event on: No Use of the product 4% 96% Emotional state 4% 96% Routine, daily life 90% 10% RESULTS

[0109] The evaluation of well-being was evaluated for users of the combination according to the invention or of the composition in the form of a lozenge alone.

[0110] The combination according to the invention advantageously makes it possible to increase the well-being of users compared to the use of the composition in tablet form alone or of the sprayable composition alone. In particular, the use of the combination according to the invention advantageously makes it possible to improve all the parameters of the well-being of users, in particular the parameters of the living environment and moral values, in addition to the dimensions of the self, social relationships, overall life satisfaction, economic situation and daily life.

[0111] These results clearly show that the combination according to the invention advantageously makes it possible to improve the well-being of the user.

[0112] An evaluation of the emotions felt by users when using the combination according to the invention was also carried out. The table below includes the results obtained.

[0113] Table 17: Emotions felt by users when using the combination according to the invention

[0114] [Tablesl7] Emotions Number of users who felt these emotions when using the combination according to the invention (in %) Satisfied 89% Confident 82% Comfortable 73% Relaxed 54% Interested 45% Happy 30% Attractive 24% Proud 21% Inspired 17% Alert 10% Excited 10% Tense 1%

[0115] Table 17 clearly shows that using the combination according to the invention advantageously generates positive emotions. In particular, the results demonstrate that users are more confident and more comfortable in their lives. The results obtained clearly demonstrate that using the combination according to the invention advantageously and surprisingly improves the quality of life of users and brings them satisfaction and happiness.

Claims

Claims

1. A combination for the treatment of halitosis, said combination comprising: - a sprayable composition comprising green tea extract and parsley essential oil, said composition being in a spray, and - a composition in the form of a lozenge comprising green tea extract and parsley essential oil.

2. Combination according to claim 1, wherein, independently in each composition, the amounts of green tea extract and parsley essential oil are respectively from 0.01 to 3% by weight and from 0.01% and 5% by weight relative to the total weight of each composition.

3. A combination according to claim 1 or 2, wherein, independently in each composition, the mass ratio of green tea extract / parsley essential oil is from 1 / 5 to 1 / 30.

4. A combination according to any one of claims 1 to 3, wherein, independently in each composition, the amount of green tea extract is from 0.01% to 0.1% by weight relative to the total weight of each composition.

5. A combination according to any one of claims 1 to 4, wherein, independently in each composition, the amount of parsley essential oil is from 0.1% to 1%, by weight relative to the total weight of each composition.

6. Combination according to any one of claims 1 to 5, in which one and / or the other of the compositions comprises in percentage by weight relative to the total weight of each composition: - 0.5 to 2%, of green tea extract, - 0.01% to 0.2%, of parsley essential oil, - 50 to 80% of glycerol esters of C8 and C10 fatty acids, - from 9 to 11% of gelatin, - excipients in sufficient quantity to constitute the sprayable composition or the composition in the form of a tablet.

7. A non-therapeutic method of treating halitosis comprising the oral administration of a combination as defined in any one of the preceding claims.

8. Non-therapeutic use of a sprayable composition comprising a green tea extract and parsley essential oil, characterized in that the sprayable composition is administered by oral spray concomitantly or successively with a composition in the form of a lozenge comprising a green tea extract and parsley essential oil for the treatment of halitosis.

9. Sprayable composition comprising a green tea extract and parsley essential oil, for use as a medicament in the treatment of halitosis, characterized in that it is administered by oral spray concomitantly or successively with a composition in the form of a lozenge comprising a green tea extract and parsley essential oil.