Periodontal Cosmetic Composition

A dry powder mixture of sodium bicarbonate and percarbonate addresses the challenges of conventional treatments by easily breaking biofilms and reducing bacterial colonization, enhancing treatment compliance and efficacy against Gram-negative bacteria.

FR3161114A3Active Publication Date: 2025-10-17SAS 3DOM
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Patent Information

Application Number
FR2024003745
Authority / Receiving Office
FR · FR
Patent Type
Utility models
Current Assignee / Owner
Filing Date
2024-04-11
Publication Date
2025-10-17
Estimated Expiration
2034-04-11

AI Technical Summary

Technical Problem

Conventional treatments for periodontitis are lengthy, expensive, painful, and difficult to prepare daily, and chemical treatments are ineffective against Gram-negative bacteria protected by biofilms, leading to poor patient compliance.

Method used

A periodontal cosmetic composition in the form of a dry powder mixture containing sodium bicarbonate and sodium percarbonate, which is activated with water to mechanically break biofilms and release bacteria, avoiding hypersensitivity issues with higher percarbonate content.

Benefits of technology

The composition effectively breaks biofilms and reduces bacterial colonization, improving treatment compliance by being easy to use and effective against Gram-negative bacteria.

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Abstract

Periodontal cosmetic composition. The invention relates to a periodontal cosmetic composition in the form of a mixture of dry powders of sodium bicarbonate, in a content greater than 97% by weight relative to the total weight of the composition; and of sodium percarbonate, in a content greater than 0% and less than or equal to 3% by weight relative to the total weight of the composition.
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Description

Title of the invention: Periodontal Cosmetic Composition

[0001] The present invention relates to the general field of the treatment of periodontosis. Periodontal diseases are infectious diseases affecting the periodontium, that is, the tissue that supports the teeth and especially the gum, alveolar bone, periodontal ligament and cementum. Periodontitis is mainly caused by bacteria that have accumulated at the base of the tooth and multiply. However, neutralizing these bacteria in this area can be difficult, as a bacterial ecosystem is created in which there is a simple bacterial colonization, as well as a biofilm itself made up of colonies of different bacteria covering the primary infection and making conventional chemical treatments ineffective. This disease causes the alveolar bone around the teeth to be destroyed slowly, but gradually and as a consequence, this leads to loss of the affected tooth.Epidemiological studies carried out in France estimate that around 16 million adults are potentially affected by this pathology in the 35 to 64 age group. According to these same studies, it is estimated that around 800,000 to 1,000,000 individuals are affected by the severe form of this pathology in France.

[0002] Although treatments for this pathology exist, they are long, expensive and sometimes painful. Consequently, preventive or prophylactic treatments have been proposed in the past, consisting of limiting the risks of contamination, particularly at the base of the tooth, by regular brushing, possibly accompanied by the application of solutions comprising substances exhibiting destructive activity on the cell membrane of bacteria, for example, mouthwashes containing surfactants. However, the bacteria responsible for this attack on the periodontium are Gram-negative and are often protected by a biofilm, making any chemical treatment very difficult.

[0003] Another treatment is also known, which consists of manually preparing a paste containing hydrogen peroxide mixed with sodium bicarbonate. The paste thus obtained must have a hold and viscosity suitable for brushing the base of the tooth. It is prepared by the affected patient just before use by taking, for example, a teaspoon of sodium bicarbonate in powder form and adding hydrogen peroxide in aqueous solution stabilized at a concentration of 5 volumes of hydrogen peroxide and mixing the two to make a paste. The abrasive nature of the sodium bicarbonate particles in the paste, applied by brushing, makes it possible to mechanically break the biofilm and release the bacterial colonies. Hydrogen peroxide, which degrades in the presence of species protonated or cationic chemicals in the presence of water in the mouth to give water and oxygen in gaseous form, makes it possible to eliminate Gram-negative and anaerobic bacteria located below the biofilm. However, this treatment has a major weakness. Making the paste preparation correctly on a daily, or even several days a day, quickly proves too difficult to carry out and restrictive for the patient. This major problem is a real obstacle to compliance with the treatment and therefore to the satisfactory treatment of this pathology.

[0004] One aspect of the invention is therefore to propose a directly usable periodontal cosmetic composition, in the form of a mixture of dry powders, and requiring only the composition to be brought into contact with water or with an aqueous environment, at the time of its use.

[0005] The periodontal cosmetic composition in the form of a mixture of dry powders as envisaged by the present invention therefore comprises a dry mixture: - sodium bicarbonate, in a content greater than 97% by weight relative to the total weight of the composition; and - sodium percarbonate, in a content greater than 0% and less than or equal to 3% by weight relative to the total weight of the composition.

[0006] The applicant has in fact surprisingly discovered that the sodium percarbonate content expressed above would make it possible to reduce, or even avoid, a phenomenon of hypersensitivity on the part of the user which could be observed with similar compositions with a higher sodium percarbonate content.

[0007] The cosmetic composition according to the invention may also comprise other ingredients in dry form, such as manufacturing adjuvants and / or taste agents, and / or aromas, etc., depending on the appearance, and / or color, etc., that one wishes to find in the final marketed product. Of course, the choice of such adjuvants would be made according to their absence of negative impact on the oxygen release functionality of the percarbonate at the time of use of the composition.

[0008] According to another aspect, the periodontal cosmetic composition, as envisaged by the present invention, is preferably in the form of a fine white powder.

[0009] According to another aspect, the sodium bicarbonate has a particle size distribution in which the percentage of particles larger than 45 microns is between 60% and 100%.

[0010] According to another aspect, the sodium bicarbonate has a particle size distribution in which the percentage of particles larger than 75 microns is between 20% and 90%.

[0011] According to another aspect, the sodium percarbonate has an average particle size of between 0.65 and 0.9 mm.

[0012] According to another aspect, the sodium percarbonate has a particle size distribution in which 95% of the particles have a size greater than 0.15 mm and less than 1.6 mm.

[0013] An example of a composition according to the invention is given below, the contents being given by weight relative to the total weight of the composition: - sodium bicarbonate: 99.7% - sodium percarbonate: 0.3%.

[0014] According to another aspect, the composition according to the invention is advantageously packaged in the form of a stick, corresponding to a single-dose packaging in the form of a small sachet, and in particular sterile and / or waterproof. The packaging may also consist of several sticks, for example, 30, 40, 50 or 60 sticks presented in a carton so as to represent one or more months of cosmetic treatment.

Claims

Claims

1. Periodontal cosmetic composition in the form of a mixture of dry powders: - sodium bicarbonate, in a content greater than 97% by weight relative to the total weight of the composition; and - sodium percarbonate, in a content greater than 0% and less than or equal to 3% by weight relative to the total weight of the composition.

2. A periodontal cosmetic composition according to claim 1, wherein the composition is in the form of a fine white powder.

3. Periodontal cosmetic composition according to claim 1, according to which the sodium bicarbonate has a particle size in which the percentage of particles larger than 45 microns is between 60% and 100%.

4. Periodontal cosmetic composition according to claim 1, according to which the sodium bicarbonate has a particle size in which the percentage of particles larger than 75 microns is between 20% and 90%.

5. A periodontal cosmetic composition according to claim 1, wherein the sodium percarbonate has an average particle size of between 0.65 and 0.9 mm.

6. A periodontal cosmetic composition according to claim 1, wherein the sodium percarbonate has a particle size in which 95% of the particles have a size greater than 0.15 mm and less than 1.6 mm.

7. Periodontal cosmetic composition according to claim 1, according to which the contents of sodium bicarbonate and sodium percarbonate are as follows, given as a percentage by weight relative to the total weight of the composition: - sodium bicarbonate: 99.7% - sodium percarbonate: 0.3%.

8. A periodontal cosmetic composition according to claim 1, wherein the composition is packaged in stick form.

9. A periodontal cosmetic composition according to claim 1, wherein the composition is packaged in the form of a carton containing multiple sticks, preferably 30, 40, 50, or 60 sticks.