Continuous production system for a liposome suspension

The millifluidic device-based system simplifies and cost-reduces liposome production by eliminating autoclaves and agitators, achieving controlled mixing and depressurization for efficient liposome formation.

FR3170339A1Pending Publication Date: 2026-06-26BIOTECH ONE
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Patent Information

Authority / Receiving Office
FR · FR
Patent Type
Applications
Current Assignee / Owner
BIOTECH ONE
Filing Date
2024-12-23
Publication Date
2026-06-26

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Abstract

The invention relates to a system (1) for producing a liposome suspension (2) comprising a first line (12) extending between a first container (10) containing an initial solution (4) of at least one active agent (3) and phospholipids (5) and a millifluidic device (13). The system (1) also comprises a second line (19) extending between a second container (20) containing carbon dioxide (6) and the millifluidic device (13). The millifluidic device (13) comprises at least one mixer (30), a plurality of tubes (30a, 30b, 30c, 30d), a plurality of reducing fittings (50a, 50b), and a micrometer valve (35). The system (1) is autoclave-free. Figure 1
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