Dietary supplement composition

Abstract

A dietary supplement composition comprises a concentrate of red cherry, an extract of Goji berry, magnesium, and tryptophan, and comprises at least 0.5mg of phytomelatonin per predetermined portion. The red cherry concentrate may be a concentrate of sour cherry, preferably Montmorency. The supplement may comprise sour cherry juice extract, lemon balm extract and / or collagen. The supplement may include at least one sweetener, flavouring, flavour modifier, surface active agent and / or foam control agent. The supplement may comprise 25-120g of red cherry concentrate, 0.3-1.5g of goji berry extract, 0.3-1.6g of magnesium salt, 0.1-6.0g of tryptophan, 0.6-3.0g of sour cherry juice extract, and 0.1-6.0g of lemon balm extract per predetermined portion. The composition may comprise at least 0.5mg per portion of phytomelatonin for alleviating the symptoms of jet lag. The composition may comprise at least 1.0mg per portion of phytomelatonin for improving sleep quality. A method of manufacturing the dietary supplement composition is also claimed, comprising the steps of admixing the ingredients. An solid or liquid oral dose formulation of the dietary supplement composition is also claimed. A method of improving sleep quality or alleviating the symptoms of jet lag is also claimed, comprising administering the dietary supplement composition to a subject.

Description

The present invention relates to a dietary supplement composition which contains one or more natural sources of melatonin. It is well known that the hormone melatonin regulates night and day cycles and therefore plays a role in sleep-wake cycles. Synthetic melatonin is commonly taken in a dietary supplement form and is recognised as a beneficial agent in sleep disorders and avoiding jet lag. Synthetic melatonin is available in several forms including tablets, capsules and drinks. Some products are available only on prescription by a medical professional. The present invention seeks to provide a dietary supplement composition which contains one or more natural sources of melatonin to assist with jet lag and sleep. The present inventors have devised a dietary supplement composition which has sufficiently high levels of natural melatonin for providing an effective, over-the-counter product. According to the present invention in one aspect there is provided a dietary supplement composition comprising at least 0.5mg of phytomelatonin per predetermined portion, wherein the dietary supplement composition comprises a concentrate of red cherry, an extract of Goji berry, at least one electrolyte and an amino acid. The electrolyte may be magnesium, sodium, potassium or zinc. The electrolyte may be in the form of a salt. The amino acid may be tryptophan. According to the present invention in a second aspect, there is provided a dietary supplement composition comprising a concentrate of red cherry, an extract of Goji berry, magnesium and tryptophan, wherein the composition comprises at least 0.5mg of phytomelatonin per predetermined portion. Phytomelatonin is the term used for melatonin (N-acetyl-5-methoxytryptamine) of plant origin. In one embodiment, the composition comprises at least 1.0 mg of phytomelatonin per predetermined portion. The composition is administered orally to assist sleep and / or to reduce jet lag. The phytomelatonin in the composition is natural, meaning that the melatonin is derived from natural source(s). The composition preferably contains no synthetic melatonin. The red cherry concentrate is preferably a concentrate of a sour cherry such as a Montmorency cherry. Any red cherry that has a relatively high level of melatonin may be used. The red cherry concentrate may be a concentrated juice. The magnesium may be a magnesium salt such as Magnesium threonate. Magnesium L-threonate is a preferred magnesium salt. The tryptophan is preferably L-tryptophan. The inventors have surprisingly been able to create a dietary supplement composition which has sufficiently high levels of phytomelatonin to provide effective products for reducing jet lag and / or improving sleep. A unique blend of four key ingredients has been devised to achieve this. A red cherry such as Montmorency cherry is provided in concentrate form together with Goji berry extract and magnesium. Goji berry is also a natural source of melatonin. Magnesium has many beneficial effects including contributing to a reduction of tiredness and fatigue and a normal functioning of the nervous system. It may be used to improve relaxation. The dietary supplement composition also includes tryptophan which is a precursor of melatonin and of the neurotransmitter serotonin, and is known to increase brain serotonin and melatonin levels. It is understood that the beneficial effects of tryptophan will increase over time if it is ingested on a regular basis. The dietary supplement composition may comprise sour cherry juice extract as a further source of melatonin. This juice extract may be obtained from a sour cherry such as Montmorency cherry. The dietary supplement composition may comprise lemon balm extract. The dietary supplement composition may comprise collagen which may be in the form of collagen peptides, particularly hydrolysed collagen peptides. Collagen peptides are beneficial to enhance recovery from exercise, for example, and thus may assist with healthy sleep patterns. The levels of melatonin in the dietary supplement composition of the present invention establish whether the composition is suitable for reducing jet lag or for assisting sleep. In this regard, when the composition comprises at least 0.5 mg of melatonin per predetermined portion, it is permissible to make a health claim under EU Commission Regulation No 432 / 2012 that the melatonin contributes to the alleviation of subjective feelings of jet lag. According to the Regulation, the claim may be used only for food which contains at least 0.5 mg of melatonin per quantified portion. In order to bear the claim, information shall be given to the consumer that the beneficial effect is obtained with a minimum intake of 0.5 mg to be taken close to bedtime on the first day of travel and on the following few days after arrival at the destination When the composition comprises at least 1.0 mg of melatonin per predetermined portion, it is permissible to make a health claim under EU Commission Regulation No 432 / 2012 that the melatonin contributes to the reduction of time taken to fall asleep. According to the Regulation, the claim may be used only for food which contains 1 mg of melatonin per quantified portion. In order to bear the claim, information shall be given to the consumer that the beneficial effect is obtained by consuming 1 mg of melatonin close to bedtime. The dietary supplement composition of the present invention may be used for adults or children. In one example, the dietary supplement composition is formulated for children to assist with sleep and may assist with Delayed Sleep-Wake Disorder (DSWPD). In an embodiment of the present invention, the concentrate of red cherry, the extract of Goji berry, the magnesium and the tryptophan are in the relative proportions of: 25 to 120 grams, preferably 25 to 110 grams of red cherry concentrate; 0.3 to 1.5 grams, preferably 0.3 to 1.4 grams of Goji berry extract; 0.3 to 1.6 grams, preferably 0.4 to 1.5 grams of a magnesium salt; and 0.1 to 0.6 grams, preferably 0.1 to 0.5 grams of tryptophan per predetermined portion. The dietary supplement composition may comprise the relative proportions of 0.6 to 3.0 grams, preferably 0.7 to 2.5 grams of sour cherry juice extract per predetermined portion. The dietary supplement composition may comprise relative proportions of 0.1 to 0.6 grams, preferably 0.1 to 0.5 grams of lemon balm extract per predetermined portion. When the composition comprises at least 0.5 mg of phytomelatonin per predetermined portion and less than 1.0 mg of phytomelatonin per predetermined portion, the concentrate of red cherry, the extract of Goji berry, the magnesium and the tryptophan are preferably in the relative proportions of: 25 to 70 grams, preferably 25 to 55 grams of red cherry concentrate; 0.3 to 0.7 grams, preferably 0.3 to 0.6 grams of Goji berry extract; 0.3 to 1.0 grams, preferably 0.4 to 0.9 grams of a magnesium salt; and 0.1 to 0.3 grams, preferably 0.1 to 0.25 grams of tryptophan per predetermined portion. The dietary supplement composition may comprise relative proportions of 0.6 to 1.2 grams, preferably 0.7 to 1.1 grams of sour cherry juice extract per predetermined portion. The dietary supplement composition may comprise relative proportions of 0.1 to 0.3 grams, preferably 0.1 to 0.25 grams of lemon balm extract per predetermined portion. When the composition comprises at least 1.0 mg of phytomelatonin per predetermined portion, the concentrate of red cherry, the extract of Goji berry, the magnesium and the tryptophan are preferably in the relative proportions of: 80 to 120 grams, preferably 90 to 110 grams of red cherry concentrate; 1.0 to 1.5 grams, preferably 1.2 to 1.4 grams of Goji berry extract; 1.2 to 1.6 grams, preferably 1.3 to 1.5 grams of a magnesium salt; and 0.2 to 0.6 grams, preferably 0.3 to 0.5 grams of tryptophan per predetermined portion. The dietary supplement composition may comprise relative proportions of 1.0 to 3.0 grams, preferably 1.5 to 2.5 grams of sour cherry juice extract per predetermined portion. The dietary supplement composition may comprise relative proportions of 0.2 to 0.6 grams, preferably 0.3 to 0.5 grams of lemon balm extract per predetermined portion. The dietary supplement composition may be a solid formulation or a liquid formulation. It may be prepared as one of a tablet, a powder, a suspension, a liquid, a capsule, a gel, a beverage or a confection or a non-baked, extruded food bar. If in powder form, the powder may be mixed in a liquid ready for use. When the dietary supplement composition is a liquid supplement composition, the composition may comprise: 10 to 40 wt%, preferably 12 to 38 wt% of red cherry concentrate, 0.20 to 0.40 wt%, preferably 0.20 to 0.35 wt% of Goji berry extract, 0.25 to 0.50 wt%, preferably 0.30 to 0.45 wt% of magnesium salt and 0.05 to 0.20 wt%, preferably 0.05 to 0.15 wt% of tryptophan, of the total liquid weight. The dietary supplement composition may comprise 0.40 to 0.60 wt%, preferably 0.45 to 0.55 wt% of sour cherry juice extract of the total liquid weight. The dietary supplement composition may comprise 0.05 to 0.20 wt%, preferably 0.05 to 0.15 wt% of lemon balm extract of the total liquid weight. When the dietary supplement composition is prepared in liquid form, it may be packaged in predetermined portions of 150ml to 500ml and preferably in predetermined portions of 150ml, 250ml or 400ml. The dietary supplement composition may comprise one or more sweeteners; and / or one or more flavourings; and / or one or more flavour modifiers; and / or one or more surface active agents; and / or one of more foam control agents. The dietary supplement composition may be flavoured using any known flavours, particularly natural flavours. In one embodiment, the dietary supplement composition comprises a peach flavouring. When the dietary supplement composition is a liquid supplement composition, the composition may comprise: 10 to 40 wt%, preferably 12 to 38 wt% of red cherry concentrate, 0.20 to 0.40 wt%, preferably 0.20 to 0.35 wt% of Goji berry extract, 0.25 to 0.50 wt%, preferably 0.30 to 0.45 wt% of magnesium salt and 0.05 to 0.20 wt%, preferably 0.05 to 0.15 wt% of tryptophan, optionally 0.40 to 0.60 wt%, preferably 0.45 to 0.55 wt% of sour cherry juice extract, optionally 0.05 to 0.20 wt%, preferably 0.05 to 0.15 wt% of lemon balm extract, optionally 0.01 to 0.50 wt%, preferably 0.01 to 0.03 wt% of one or more foam control agents, optionally 0.15 to 0.40 wt%, preferably 0.20 to 0.30 wt% of one or more non-magnesium minerals, optionally 0.15 to 0.40 wt%, preferably 0.20 to 0.30 wt% of one or more flavourings, optionally 0.03 to 0.12 wt%, preferably 0.05 to 0.09 wt% of one or more sweeteners, and optionally 0.05 to 0.30 wt%, preferably 0.10 to 0.20 wt% of one or more flavour modifiers of the total liquid weight. In one embodiment, when the composition comprises at least 0.5 mg of phytomelatonin per predetermined portion and less than 1.0 mg of phytomelatonin per predetermined portion, the liquid supplement composition may comprise: 25 to 40 wt%, preferably 30 to 35 wt% of red cherry concentrate, 0.20 to 0.40 wt%, preferably 0.20 to 0.30 wt% of Goji berry extract, 0.25 to 0.40 wt%, preferably 0.25 to 0.35 wt% of magnesium salt and 0.05 to 0.20 wt%, preferably 0.05 to 0.15 wt% of tryptophan, optionally 0.40 to 0.60 wt%, preferably 0.45 to 0.55 wt% of sour cherry juice extract, optionally 0.05 to 0.20 wt%, preferably 0.05 to 0.15 wt% of lemon balm extract, optionally 0.01 to 0.04 wt%, preferably 0.01 to 0.03 wt% of one or more foam control agents, optionally 0.15 to 0.40 wt%, preferably 0.20 to 0.30 wt% of one or more non-magnesium minerals, optionally 0.15 to 0.40 wt%, preferably 0.20 to 0.30 wt% of one or more flavourings, optionally 0.03 to 0.12 wt%, preferably 0.05 to 0.09 wt% of one or more sweeteners, and optionally 0.05 to 0.30 wt%, preferably 0.10 to 0.20 wt% of one or more flavour modifiers of the total liquid weight. In this embodiment, the composition may comprise: 30 to 38 wt%, preferably about 34 wt% of red cherry concentrate, 0.22 to 0.28 wt%, preferably about 0.25 wt% of Goji berry extract, 0.29 to 0.35 wt%, preferably about 0.32 wt% of magnesium salt and 0.08 to 0.12 wt%, preferably about 0.10 wt% of tryptophan, of the total liquid weight. The predetermined portion may be 150ml. In another embodiment, when the composition comprises at least 0.5 mg of phytomelatonin per predetermined portion and less than 1.0 mg of phytomelatonin per predetermined portion, the liquid supplement composition may comprise: 10 to 25 wt%, preferably 10 to 20 wt% of red cherry concentrate, 0.20 to 0.40 wt%, preferably 0.20 to 0.30 wt% of Goji berry extract, 0.35 to 0.50 wt%, preferably 0.40 to 0.45 wt% of magnesium salt and 0.05 to 0.20 wt%, preferably 0.05 to 0.15 wt% of tryptophan, optionally 0.40 to 0.60 wt%, preferably 0.45 to 0.55 wt% of sour cherry juice extract, optionally 0.05 to 0.20 wt%, preferably 0.05 to 0.15 wt% of lemon balm extract, optionally 0.01 to 0.04 wt%, preferably 0.01 to 0.03 wt% of one or more foam control agents, optionally 0.15 to 0.40 wt%, preferably 0.20 to 0.30 wt% of one or more non-magnesium minerals, optionally 0.15 to 0.40 wt%, preferably 0.20 to 0.30 wt% of one or more flavourings, optionally 0.03 to 0.12 wt%, preferably 0.05 to 0.09 wt% of one or more sweeteners, and optionally 0.05 to 0.30 wt%, preferably 0.10 to 0.20 wt% of one or more flavour modifiers of the total liquid weight. In this embodiment, the composition may comprise: 14 to 16 wt%, preferably about 15 wt% of red cherry concentrate, 0.22 to 0.28 wt%, preferably about 0.25 wt% of Goji berry extract, 0.40 to 0.45 wt%, preferably about 0.43 wt% of magnesium salt and 0.08 to 0.12 wt%, preferably about 0.10 wt% of tryptophan, of the total liquid weight. The predetermined portion may be 250ml. When the composition comprises at least 1.0 mg of phytomelatonin per predetermined portion, the liquid supplement composition may comprise: 20 to 35 wt%, preferably 20 to 30 wt% of red cherry concentrate, 0.20 to 0.40 wt%, preferably 0.30 to 0.35 wt% of Goji berry extract, 0.25 to 0.45 wt%, preferably 0.30 to 0.40 wt% of magnesium salt and 0.05 to 0.20 wt%, preferably 0.05 to 0.15 wt% of tryptophan, optionally 0.40 to 0.60 wt%, preferably 0.45 to 0.55 wt% of sour cherry juice extract, optionally 0.05 to 0.20 wt%, preferably 0.05 to 0.15 wt% of lemon balm extract, optionally 0.01 to 0.04 wt%, preferably 0.01 to 0.03 wt% of one or more foam control agents, optionally 0.15 to 0.40 wt%, preferably 0.30 to 0.40 wt% of one or more non-magnesium minerals, optionally 0.15 to 0.40 wt%, preferably 0.20 to 0.30 wt% of one or more flavourings, optionally 0.03 to 0.12 wt%, preferably 0.05 to 0.09 wt% of one or more sweeteners, and optionally 0.05 to 0.30 wt%, preferably 0.10 to 0.20 wt% of one or more flavour modifiers of the total liquid weight. In this embodiment, the composition may comprise: 22 to 28 wt%, preferably about 25 wt% of red cherry concentrate, 0.29 to 0.35 wt%, preferably about 0.32 wt% of Goji berry extract, 0.40 to 0.40 wt%, preferably about 0.35 wt% of magnesium salt and 0.08 to 0.12 wt%, preferably about 0.10 wt% of tryptophan, of the total liquid weight. The predetermined portion may be 400ml. In the present invention, the red cherry concentrate may have a value of degree Brix of at least 50, preferably of at least 60. Degree Brix is a calibration of the refractive index of a solution against dissolved sucrose. It is therefore a measure of the dissolved solids in a liquid, and is commonly used to measure dissolved sugar content of an aqueous solution. One degree Brix is 1 gram of sucrose in 100 grams of solution and represents the strength of the solution as percentage by mass. The present invention also relates to a method of manufacturing a dietary supplement composition, an oral dose formulation of a food for dietary supplement and a method of improving sleep quality or alleviating the symptoms of jet lag comprising administering to a subject a dietary supplement composition. The invention will now be described, by way of example only, with reference to the accompanying figure. A dietary supplement composition according to an embodiment of the present invention is a 150ml beverage having the following composition. INGREDIENT QTY grams PER LITRE QTY grams PER BOTTLE % of Unit Total Filtered Water 736.5 110.475 73.65% Red Cherry Concentrate 339 50.850 33.90% Sour Cherry Juice Extract 5 0.750 0.50% Magnesium Salt 3.2424 0.486 0.32% Goji Berry Extract 2.5 0.375 0.25% Non-magnesium mineral 2.5 0.375 0.25% Flavouring 2.2 0.330 0.22% Trytophan 1 0.150 0.10% Lemon Balm Extract 1 0.150 0.10% Flavour modifier 1 1 0.150 0.10% Sweetener 0.65 0.098 0.07% Flavour modifier 2 0.5 0.075 0.05% Foam Control Agent 0.15 0.023 0.02% A dietary supplement composition according to an embodiment of the present invention is a 250ml beverage having the following composition. INGREDIENT QTY grams PER LITRE QTY grams PER BOTTLE % of Unit Total Filtered Water 858.5 171.700 85.85% Red Cherry Concentrate 153.68 30.736 15.37% Sour Cherry Juice Extract 5 1.000 0.50% Magnesium Salt 4.28 0.856 0.43% Goji Berry Extract 2.5 0.500 0.25% Non-magnesium mineral 2.5 0.500 0.25% Flavouring 2.2 0.440 0.22% Tryptophan 1 0.200 0.10% Lemon Balm Extract 1 0.200 0.10% Flavour modifier 1 1 0.200 0.10% Sweetener 0.65 0.130 0.07% Flavour modifier 2 0.5 0.100 0.05% Foam Control Agent 0.15 0.030 0.02% A dietary supplement composition according to another embodiment of the present invention is a 400ml beverage having the following composition. INGREDIENT QTY grams PER LITRE QTY grams PER BOTTLE % of Unit Total Filtered Water 789.5 315.800 78.95% Red Cherry Concentrate 253.6 101.440 25.36% Sour Cherry Juice Extract 5 2.000 0.50% Non-magnesium mineral 3.5 1.400 0.35% Magnesium Salt 3.2424 1.297 0.32% Goji Berry Extract 2.5 1.000 0.25% Flavouring 2.2 0.880 0.22% Tryptophan 1 0.400 0.10% Lemon Balm Extract 1 0.400 0.10% Flavour modifier 1 1 0.400 0.10% Sweetener 0.8 0.320 0.08% Flavour modifier 2 0.5 0.200 0.05% Foam control agent 0.15 0.060 0.02 These ingredients may be sourced from the following suppliers in the UK. Ingredient details UK Supplier Sour Cherry Juice Extract Blue Sky Botanies Ltd Product code ESRCHR002 Goji Berry (Org) Extract 20E 1:2.5 Blue Sky Botanies Ltd Product code EGOJI003 Lemon Balm Extract 20EpH 1:2.5 Blue Sky Botanies Ltd Product code ELBALM001 Red Cherry Concentrate 65 Brix Clarified Gerald McDonald &Co Ltd Product code 3421.05 Flavouring: Peach Flavour IMCD UK Ltd Product code AO-696-755-0 Foam control agent: FoamDoctor® Brenntag SE Product code F2010 Flavour modifier 1: TasteSense™ Masking Flv Kerry Ingredients &Flavours Ltd Product code 20497883 Flavour modifier 2: TasteSenseTM SR LQD 100714089 Kerry Ingredients &Flavours Ltd Product code 20465384 Non-magnesium mineral Trisodium Citrate Dihydrate Nutrition Grade (~34% Na) Nutraceuticals Group Europe Ltd Product code NIGEMIN003402 Magnesium Salt Magnesium Threonate Nutrition Grade (~7% Mg) Nutraceuticals Group Europe Ltd Product code NIGEMIN002425 L-Tryptophan Vegan Fermented Nutraceuticals Group Europe Ltd Product code NIGEAMA006901 Sweetener: Stevia Extract Rebaudioside A 97% (Stevia rebaudiana) Nutraceuticals Group Europe Ltd Product code NIGESWE00701 The Red Cherry Concentrate may be 65 Brix Clarified and produced using the steps set out in the diagram of figure 1. The red cherry fruit, once screened for quality, is crushed. It is then heated and cooled before being pressed to extract raw juice which is subsequently concentrated. During a 5 clarification process, pectinases and pectolytic enzymes are degraded and bentonite and fining agents are filtered out. The product is a dark red to purple coloured clear viscous liquid with a flavour and aroma characteristic of red / sour cherry. The Goji Berry extract is made from natural plant material (Lycium barbarum) and the solvent in this ingredient is 20% ethanol (E)). 40 grams of botanical (the fruit) is used to manufacture 100 grams of product. The botanical to solvent ratio is 1:2.5. The solvent in the sour cherry juice extract is 20% ethanol. The lemon balm extract is made from natural plant material (Melissa officinalis) and the solvent in this ingredient is 20% ethanol (E). 40 grams of botanical (the aerial parts) is used to manufacture 100 grams of product. The botanical to solvent ratio is 1:2.5. FoamDoctor® F2010 is a polydimethylsiloxane (silicone, E900 grade) based food safe foam control agent. The flavour modifier TasteSense™ Masking Flv comprises flavouring preparations, natural flavouring substances, water, Glucono deltalactone E575 (20% max), Propylene glycol E1520 (15% max) and Sodium lactate E325 (15% max). The flavour modifier Flavour TasteSenseTM SR LQD 100714089 comprises flavouring preparations, natural flavouring substances, water, Propylene glycol E1520 (33% max) and Maltodextrin. The ingredients listed above provide a good flavour profile for the beverage which has a cherry and peach flavour. The dietary supplement composition is not to limited to these specific ingredients or to this flavour. In other embodiments, the dietary supplement composition has different fruit flavours combined with the cherry flavour. Examples are cherry and pineapple, cherry and apple, cherry and orange, cherry and mango, cherry and tropical fruit. The dietary supplement composition may also have other flavours combined with the cherry flavour. When provided as a beverage, the dietary supplement composition may be in the format of a still or carbonated liquid. Examples Test Reports: Phytomelatonin Analysis Cherry and Peach 150ml beverage - jet lag claim Sample 1 416ng phytomelatonin / lOOg Sample 2 409ng phytomelatonin / lOOg Sample 3 422ng phytomelatonin / lOOg Cherry and Peach 400ml beverage - jet lag claim Sample 1 466ng phytomelatonin / lOOg Sample 2 472ng phytomelatonin / lOOg Cherry and Peach 250ml beverage - sleep claim Sample 1 502ng phytomelatonin / lOOg Sample 2 499ng phytomelatonin / lOOg Sample 3 505ng phytomelatonin / lOOg Cherry and Peach 400ml beverage - sleep claim Sample 1 465ng phytomelatonin / lOOg

Claims

1. A dietary supplement composition comprising a concentrate of red cherry, an extract of Goji berry, magnesium and tryptophan, wherein the composition comprises at least 0.5mg of phytomelatonin per predetermined portion.

2. A dietary supplement composition as claimed in claim 1, wherein the composition comprises at least 1.0 mg of phytomelatonin per predetermined portion.

3. A dietary supplement composition as claimed in claim 1 or claim 2, wherein the red cherry concentrate is a concentrate of a sour cherry, preferably Montmorency cherry.

4. A dietary supplement composition as claimed in any preceding claim, further comprising sour cherry juice extract and / or lemon balm extract and / or collagen.

5. A dietary supplement composition as claimed in any preceding claim, wherein the magnesium is a magnesium salt and the concentrate of red cherry, the extract of Goji berry, the magnesium and the tryptophan are in the relative proportions of:25 to 120 grams, preferably 25 to 110 grams of red cherry concentrate;0.3 to 1.5 grams, preferably 0.3 to 1.4 grams of Goji berry extract;0.3 to 1.6 grams, preferably 0.4 to 1.5 grams of the magnesium salt; and0.1 to 0.6 grams, preferably 0.1 to 0.5 grams of tryptophan per predetermined portion.

6. A dietary supplement composition as claimed in claim 5 when dependent on claim 4, further comprising the relative proportions of 0.6 to 3.0 grams, preferably 0.7 to 2.5 grams of sour cherry juice extract and / or the relative proportions of 0.1 to 0.6 grams, preferably 0.1 to 0.5 grams of lemon balm extract per predetermined portion.

7. A dietary supplement composition as claimed in any preceding claim being a liquid supplement composition comprising:10 to 40 wt%, preferably 12 to 38 wt% of red cherry concentrate,0.20 to 0.40 wt%, preferably 0.20 to 0.35 wt% of Goji berry extract, 0.25 to 0.50 wt%, preferably 0.30 to 0.45 wt% of magnesium salt and 0.05 to 0.20 wt%, preferably 0.05 to 0.15 wt% of tryptophan,of the total liquid weight of the composition.

8. A dietary supplement composition as claimed in claim 7 when dependent on claims 4 to 6, further comprising 0.40 to 0.60 wt%, preferably 0.45 to 0.55 wt% of sour cherry juice extract of the total liquid weight and / or 0.05 to 0.20 wt%, preferably 0.05 to 0.15 wt% of lemon balm extract of the total liquid weight of the composition.

9. A dietary supplement composition as claimed in any preceding claim, further comprising one or more sweeteners; and / or one or more flavourings; and / or one or more flavour modifiers; and / or one or more surface active agents; and / or one or more foam control agents.

10. A method of manufacturing a dietary supplement composition comprising admixing a concentrate of red cherry, an extract of Goji berry, magnesium and tryptophan, wherein the composition is the dietary supplement composition of any preceding claim.

11. An oral dose formulation of a food for dietary supplement according to any one of claims 1 to 9, being a solid formulation or a liquid formulation.

12. A method of improving sleep quality or alleviating the symptoms of jet lag comprising administering to a subject a dietary supplement composition according to any one of claims Ito 9.

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