Compositions comprising an american cranberry extract and phospholipids

Abstract

The present invention relates to a composition comprising an extract of American fruit tendril in combination with a phospholipid and its use in the prevention and treatment of urinary tract infections. The invention also relates to a method for preparing said composition, and to a formulation for oral administration comprising said composition.

Description

Abstract Abdominal ultrasound examination method, system and device The present invention relates to compositions comprising an American cranberry extract combined with phospholipids, and the use thereof in the prevention and treatment of urinary tract infections. The invention also relates to processes for the preparation of said compositions, and formulations for oral administration comprising said compositions.

Claims

1. A composition comprising: a) a Vaccinium macrocarpon extract in an amount of 20-50% by weight of the total weight of the composition; and b) at least one phospholipid in an amount of 50-80% by weight of the total weight of the composition.

2. The composition according to claim 1, wherein the Vaccinium macrocarpon extract has a proanthocyanidin content of 15-40% by weight of the total weight of the extract.

3. The composition according to claim 1 or 2, further comprising one or more technical excipients selected from water-soluble or water-insoluble diluents, lubricants and / or glidants and surfactants.

4. The composition according to claim 3, wherein the diluent is not maltodextrin, mannitol, isomalt or a combination thereof.

5. A process for the preparation of a composition comprising: a) a Vaccinium macrocarpon extract in an amount of 20-50% by weight of the total weight of the composition; and b) at least one phospholipid in an amount of 50-80% by weight of the total weight of the composition, the process comprising dissolving or dispersing the Vaccinium macrocarpon extract, the at least one phospholipid and optionally one or more technical excipients selected from water-soluble or water-insoluble diluents, lubricants and / or glidants and surfactants in an organic solvent at a temperature of 30-90°C to obtain a solution or dispersion, and then drying the solution or dispersion to obtain a solid composition.

6. The process according to claim 5, wherein the organic solvent is selected from ethanol, ethyl acetate and acetone.

7. The process according to claim 5 or 6, comprising simultaneously dissolving or dispersing the Vaccinium macrocarpon extract and the at least one phospholipid, and then optionally adding one or more excipients.

8. The process according to claim 5 or 6, comprising dissolving or dispersing the Vaccinium macrocarpon extract and the at least one phospholipid in an organic solvent to obtain a solution or dispersion, and then adding at least one phospholipid or Vaccinium macrocarpon extract to the solution or dispersion, and optionally adding one or more technical excipients.

9. The process according to any one of claims 5-8, wherein the one or more excipients are used in an amount such that their weight is 1-30% of the total weight of the composition.

10. A solid composition obtainable by the process of any one of claims 5-9.

11. Use of the composition of any one of claims 1-5 or 10 for the preparation of a pharmaceutical and / or nutritional composition for the prevention or treatment of lower urinary tract infections.

12. A solid formulation comprising the composition of any one of claims 1-5 and one or more pharmaceutically and / or nutritionally acceptable excipients mixed therewith.

13. The formulation according to claim 12, further comprising another portion of Vaccinium macrocarpon extract in free form, not mixed with phospholipids.

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