Antiperspirant composition

Abstract

To provide an antiperspirant composition that can act on sweat glands to control the secretion of sweat without closing sweat pores.SOLUTION: An antiperspirant composition contains a specific amount of ammonium glycyrrhizate.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to antiperspirant compositions. [Background technology]

[0002] Human sweat glands are important organs that regulate body temperature, primarily through the secretion of sweat. However, excessive sweating that is unnecessary for body temperature regulation, as well as the odor of metabolites produced by microbial decomposition of sweat and the odor produced by oxidation, can be unpleasant to humans. Therefore, body odor suppressant cosmetics and antiperspirant cosmetics have been known to date that contain antiperspirant ingredients that exert a physical antiperspirant effect by blocking sweat pores with metal ions such as aluminum chloride, and also contain bactericides or antibacterial agents.

[0003] Incidentally, Patent Document 1 describes that glycyrrhizinic acid has an antiperspirant effect. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Japanese Patent Publication No. 52-105221 Summary of the Invention [Problem to be solved by the invention]

[0005] However, although Patent Document 1 reports an antiperspirant containing glycyrrhizinic acid as an active ingredient, its antiperspirant effect is insufficient and there is room for improvement.

[0006] The present invention has been made in view of the above problems, and its object is to provide an antiperspirant composition that can control sweat secretion by acting on sweat glands without blocking sweat pores. [Means for solving the problem]

[0007] In order to solve the above problems, the inventors of the present invention conducted extensive research and found that, among glycyrrhizinic acid, its derivatives and salts thereof, ammonium glycyrrhizinate is a particularly excellent antiperspirant ingredient.

[0008] That is, the present invention includes the following configurations.

[0009] <1> Contains ammonium glycyrrhizinate as an antiperspirant ingredient. The antiperspirant composition contains 0.05 to 1.00% by mass of ammonium glycyrrhizinate.

[0010] <2> 2. The antiperspirant composition according to claim 1, wherein the ammonium glycyrrhizinate contains at least one of monoammonium glycyrrhizinate and diammonium glycyrrhizinate. [Effects of the Invention]

[0011] According to the present invention, it is possible to provide an antiperspirant composition that can control sweat secretion by acting on sweat glands without blocking sweat pores. DETAILED DESCRIPTION OF THE INVENTION

[0012] The present invention is described below, but is not limited thereto. The present invention is not limited to the individual configurations described below, and various modifications are possible within the scope of the claims. Furthermore, embodiments or examples obtained by appropriately combining the technical means disclosed in different embodiments or examples are also included in the technical scope of the present invention. Furthermore, new technical features can be created by combining the technical means disclosed in each embodiment. All academic and patent literature described in this specification is incorporated herein by reference.

[0013] Unless otherwise specified in this specification, the term "X to Y" representing a numerical range means "at least X and at most Y." Furthermore, unless otherwise specified in this specification, the mass % representing the content of a component is a value where the mass of the entire antiperspirant composition is 100 mass %.

[0014] 1. Antiperspirant Composition The antiperspirant composition according to the present invention contains ammonium glycyrrhizinate as an active ingredient, and the content of the ammonium glycyrrhizinate is 0.05 to 1.00% by mass.

[0015] The antiperspirant composition of the present invention can control sweat secretion without blocking sweat pores. As disclosed in International Application No. PCT / JP2019 / 011137, the present inventors have discovered that certain compounds, including carbenoxolone, exert antiperspirant effects by acting on sweat glands without blocking sweat pores. Because ammonium glycyrrhizinate shares a common structure with carbenoxolone, it is believed to exhibit a similar mechanism of action. While glycyrrhizinic acid has been known to have antiperspirant effects, it was not previously known that its salt, ammonium glycyrrhizinate, exhibits significantly higher antiperspirant effects, which is surprising. Furthermore, ammonium glycyrrhizinate is easily soluble in various solvents.

[0016] A content of ammonium glycyrrhizinate of 0.05% by mass or more is preferable from the viewpoint of suppressing sweating. The content is more preferably 0.10% by mass or more, and even more preferably 0.30% by mass or more. A content of 1.00% by mass or less is preferable from the viewpoint of reducing the burden on the user. The content is more preferably 0.90% by mass or less, and even more preferably 0.80% by mass or less.

[0017] The antiperspirant composition preferably contains, as the ammonium glycyrrhizinate, at least one of monoammonium glycyrrhizinate and diammonium glycyrrhizinate.

[0018] The antiperspirant composition of the present invention may contain other ingredients within the range that does not impair the function of the present invention, such as, but not limited to, water, surfactants, alcohols, freshening agents, plant extracts, fragrances, sequestering agents, antioxidants, preservatives, thickeners, etc.

[0019] Examples of the surfactants include nonionic surfactants such as alkyl glyceryl ethers, polyoxyalkylene alkyl ethers, polyoxyalkylene hydrogenated castor oil, glycol fatty acid esters, glycerin fatty acid esters, polyoxyalkylene glyceryl ether fatty acid esters, sorbitan fatty acid esters, polyoxyalkylene sorbitan fatty acid esters, and silicone surfactants; anionic surfactants such as alkyl sulfate ester salts, polyoxyethylene alkyl ether sulfate salts, acyl N-methyl taurine salts, alkyl ether phosphate ester salts, and N-acyl amino acid salts; cationic surfactants such as alkyltrimethylammonium chloride and dialkyldimethylammonium chloride; and amphoteric surfactants such as alkyldimethylaminoacetic acid betaine and alkylamidopropyldimethylaminoacetic acid betaine.

[0020] The alcohol includes, for example, ethanol.

[0021] Examples of the cooling agent include menthol, menthyl glyceryl ether, menthyl lactate, peppermint oil, camphor, icilin, and the like.

[0022] Examples of the antioxidant include tocopherol and its derivatives, ascorbic acid and its derivatives, and the like.

[0023] Examples of the sequestering agent include edetate, phosphoric acid, sodium polyphosphate, and the like.

[0024] Examples of the thickener include dextran, pullulan, arabinogalactan, guar gum, tara gum, locust bean gum, konjac mannan, and tamarind seed gum.

[0025] The antiperspirant composition may or may not contain an antiperspirant component (such as an aluminum compound) that exerts a physical antiperspirant effect by blocking sweat pores.

[0026] As explained above, the antiperspirant composition according to the present invention contains ammonium glycyrrhizinate as an active ingredient for controlling sweat secretion by sweat glands, and therefore acts on the secretory ducts of sweat glands to control their movement during sweat secretion. Thus, the antiperspirant composition according to the present invention can act on sweat glands to control sweat secretion without blocking sweat pores.

[0027] 2. Dosage Form, Manufacturing Method, and Use of Antiperspirant Composition The antiperspirant composition according to the present invention may be in the form of an aerosol, lotion, mist, emulsion, gel, cream, stick, sheet, or the like.

[0028] The product form of the antiperspirant composition according to the present invention is not particularly limited, but it may be in the form of a product filled in a pump container, a tube container, a jar container, an aerosol container, or the like.

[0029] The method for producing the antiperspirant composition of the present invention is not particularly limited, and known production methods can be used. Examples of the method for producing the antiperspirant composition include a method in which the above-mentioned components are mixed and stirred with a known mixing device such as a propeller mixer, a disperse mixer, or a paddle mixer to homogenize the components.

[0030] The antiperspirant composition according to the present invention is expected to be used, for example, as an antiperspirant for cosmetic applications, an antiperspirant for medical applications, etc. Furthermore, the antiperspirant composition according to the present invention is expected to be used as an antiperspirant that meets the needs of the user, such as an antiperspirant that completely inhibits sweat secretion, an antiperspirant that reduces sweat secretion, or the like. [Example]

[0031] The present invention will be described in detail below with reference to examples, but the embodiments of the present invention are not limited to these examples. The contents in Table 1 are amounts (% by mass) converted to pure contents.

[0032] [Method for measuring sweat inhibition rate] At room temperature, the obtained composition of Table 1 was applied to the skin of the outer part of the forearm by 1 cm 2 The composition was applied in a circular pattern. The lower limbs were then bathed in warm water at approximately 42°C to induce sweating. Using a sweat meter (device name: SKN-2000, manufactured by Nishizawa Electric Instruments Manufacturing Co., Ltd.), the average amount of sweating (mg / min) at the site where the composition of the following Examples and Comparative Examples was applied (sample application site) was measured during a 10-minute period in which the amount of sweating was stable. The sweat inhibition rate was then calculated using the following formula (1), with Comparative Example 1 as the standard.

[0033] Sweat suppression rate (%)=100−[(average sweat amount of the corresponding Example or Comparative Example other than Comparative Example 1 / average sweat amount of Comparative Example 1)×100] (1) [Examples 1 to 3 and Comparative Examples 1 to 3] The antiperspirants of Examples 1 and 2 and Comparative Examples 1 to 3 were prepared by blending the components as shown in Table 1. Table 1 also shows the measurement results of the perspiration inhibition rate.

[0034] [Table 1]

[0035] As can be seen from Table 1, Examples 1 to 4, which contained 0.05% by mass or more of ammonium glycyrrhizinate, had higher sweating inhibition rates than Comparative Examples 1 to 3. This demonstrates that ammonium glycyrrhizinate has the effect of inhibiting sweating. Furthermore, dipotassium glycyrrhizinate, which is a salt of glycyrrhizinic acid, did not inhibit sweating. Therefore, it can be said that, of glycyrrhizinic acid and its salts, ammonium glycyrrhizinate is the most effective in inhibiting sweating. [Industrial Applicability]

[0036] The present invention can be suitably used as an antiperspirant.

Claims

1. A cosmetic method for controlling sweat secretion on the skin, comprising: Contains ammonium glycyrrhizinate as an antiperspirant ingredient. applying to the skin an antiperspirant composition containing 0.05 to 1.00% by mass of ammonium glycyrrhizinate; Cosmetic procedures (excluding medical procedures).

2. A cosmetic method as described in Claim 1, wherein the antiperspirant composition contains at least one of monoammonium glycyrrhizinate and diammonium glycyrrhizinate as the ammonium glycyrrhizinate.

3. The cosmetic method described in claim 1, wherein the antiperspirant composition controls sweat secretion without blocking sweat pores.

4. The cosmetic method described in claim 1, wherein the antiperspirant composition acts on the secretory ducts of sweat glands to control the movement of the secretory ducts of sweat glands during sweat secretion.

5. The cosmetic method described in claim 1, wherein the antiperspirant composition contains ethanol.

6. Use of an antiperspirant composition as an active ingredient in a cosmetic method (excluding medical procedures) for controlling sweat secretion on the skin, comprising: The antiperspirant composition contains ammonium glycyrrhizinate as an antiperspirant component, The content of the ammonium glycyrrhizinate is 0.05 to 1.00% by mass.