Isoindolinone Compounds

Abstract

Disclosed herein are compounds of formula (I) or pharma- ceutically acceptable salts or stereoisomers thereof, which are used as modulators of cereblon, particularly in the treatment of abnormal cell proliferation in mammals, particularly humans. TIFF2024504932000118.tif46165

Description

[Technical Field]

[0001] cross reference This application claims priority to Swiss Patent Application No. 00025 / 21, filed January 13, 2021, Swiss Patent Application No. 00386 / 21, filed April 14, 2021, Swiss Patent Application No. 00655 / 21, filed June 4, 2021, and U.S. Provisional Application No. 63 / 281,049, filed November 18, 2021, the contents of each of which are incorporated herein by reference in their entirety.

[0002] The present disclosure relates to novel compounds as modulators of cereblon. The disclosure also relates to methods for preparing these compounds, compositions containing these compounds, and methods for their use in the treatment of abnormal cell growth in mammals, particularly humans. [Background technology]

[0003] The ubiquitin-proteasome system can be manipulated using different small molecules to trigger targeted degradation of specific proteins of interest. Using small molecule degraders to promote targeted degradation of pathogenic proteins is emerging as a new modality in the treatment of disease. One such modality relies on redirecting the activity of E3 ligases, such as cereblon, using low-molecular-weight compounds (called molecular glues) to promote polyubiquitination and ultimately the proteasomal degradation of new protein substrates involved in disease pathogenesis. The molecular glues bind to both the E3 ligase and the target protein, thereby mediating changes to the ligase surface and enabling its interaction with the target protein. Compounds particularly relevant to the E3 ligase cereblon are the IMiD (immunomodulatory imide drug) class, including thalidomide, lenalidomide, and pomalidomide. These IMiDs have been approved by the FDA for use in hematological malignancies. However, compounds that can efficiently target other diseases, particularly other types of cancer, are still needed. Summary of the Invention [Means for solving the problem]

[0004] It is therefore an object of the present disclosure to advance the state of the art of cereblon modulators and provide modulators for novel applications in different diseases, particularly different cancers.

[0005] In some embodiments, compounds are provided for use in treating solid tumors, such as for use in treating lung cancer, e.g., non-small cell lung cancer (e.g., squamous cell lung cancer) and small cell lung cancer, breast cancer, and neuroendocrine cancers, e.g., neuroendocrine prostate cancer (NEPC), such as castration-resistant neuroendocrine prostate cancer, and lung neuroendocrine tumors (Lu-NETs). In some embodiments, compounds are provided for use in treating blood-borne (or hematologic) cancers, such as for use in treating leukemia (e.g., acute myeloid leukemia (AML)) and myeloma (e.g., multiple myeloma (MM)).

[0006] In a first aspect, the present disclosure is directed to a compound of formula I, or a pharmaceutically acceptable salt or stereoisomer thereof: [ka] During the ceremony, X 1 is a linear or branched chain C 1~6 Alkyl, C 3~8 Cycloalkyl, C 6~10 aryl, 5- to 10-membered heteroaryl, 4- to 8-membered heterocycloalkyl; X 1 is unsubstituted or halogen, straight or branched chain C 1~6 Alkyl, straight or branched chain C 1~6 Heteroalkyl, CF3, CHF2, CMeF2, -O-CHF2, -O-(CH2)2-OMe, OCF3, C 1~6 Alkylamino, -CN, -N(H)C(O)-C 1~6 Alkyl, -OC(O)-C 1~6 Alkyl, -OC(O)-C 1~4Alkylamino, -C(O)OC 1~6 Alkyl, -COOH, -C 1~6 AlkylC(O)OH, -C 1~6 Alkyl C(O)OC 1~6 Alkyl, NH2, C 1~4 Alkoxy, C 1~4 Alkylhydroxy, -CH2F, -N(H)C(O)-OC 1~6 substituted with one or more of alkyl, and C(OH)(CF), or X 1 together with the N atom of the carbamate form a 4- to 8-membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~6 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, -N(H)C(O)-C 1~6 Alkyl, -OC(O)-C 1~6 Alkyl, -C(O)OC 1~6 Alkyl, -COOH, -C 1~6 AlkylC(O)OH, -C 1~6 Alkyl C(O)OC 1~6 Alkyl, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy; X 2 is H, C 3~6 Cycloalkyl, C 6~10 aryl, 5- to 10-membered heteroaryl, or 4- to 8-membered heterocycloalkyl; and X 2 is unsubstituted or a straight or branched chain C 1~6 Alkyl, -C 1~4 Alkoxy, NH2, NMe2, halogen, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, and C 1~4 substituted with one or more of alkylhydroxy; L 1 is a covalent bond, linear or branched C 1~6 is alkyl, L2 is a covalent bond, linear or branched C 1~6 is alkyl, L 3 is a covalent bond, linear or branched C 1~6 Alkyl, -O-, or -C 1~4 Alkoxy, straight or branched chain C 1~6 The alkyl is unsubstituted or substituted with one or more halogens.

[0007] In some embodiments, X 1 is a linear or branched chain C 1~6 Alkyl, C 3~6 Cycloalkyl, C 6~10 aryl, 5- to 10-membered heteroaryl, 4- to 8-membered heterocycloalkyl; X 1 is unsubstituted or substituted with halogen, linear or branched C 1~6 Alkyl, straight or branched chain C 1~6 Heteroalkyl, CF3, CHF2, CMeF2, -O-CHF2, -O-(CH2)2-OMe, OCF3, C 1~6 Alkylamino, -CN, -N(H)C(O)-C 1~6 Alkyl, -OC(O)-C 1~6 Alkyl, -OC(O)-C 1~4 Alkylamino, -C(O)OC 1~6 Alkyl, -COOH, -C 1~6 AlkylC(O)OH, -C 1~6 Alkyl C(O)OC 1~6 Alkyl, NH2, C 1~4 Alkoxy, and C 1~4 substituted with one or more of alkylhydroxy; or X 1 together with the N atom of the carbamate to form a 4- to 8-membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight- or branched-chain -C 1~6 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, -N(H)C(O)-C1~6 Alkyl, -OC(O)-C 1~6 Alkyl, -C(O)OC 1~6 Alkyl, -COOH, -C 1~6 AlkylC(O)OH, -C 1~6 Alkyl C(O)OC 1~6 Alkyl, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy; X 2 is H, C 3~6 Cycloalkyl, C 6~10 aryl, 5- to 10-membered heteroaryl, or 4- to 8-membered heterocycloalkyl; and X 2 is unsubstituted or a straight or branched chain C 1~6 Alkyl, -C 1~4 Alkoxy, NH2, NMe2, halogen, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, and C 1~4 substituted with one or more of alkylhydroxy; L 1 is a covalent bond, linear or branched C 1~6 is alkyl, L 2 is a covalent bond, linear or branched C 1~6 is alkyl, L 3 is a covalent bond, linear or branched C 1~6 Alkyl, -O-, -C 1~4 It is an alkoxy.

[0008] In some embodiments of the compound of Formula I, X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy; or X 1 together with the N atom of the carbamate to form a 4- to 8-membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight- or branched-chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more alkoxy groups.

[0009] In some embodiments of the compound of Formula I, X 2 is H, C 3~6 cycloalkyl, C6 aryl, 5- to 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Alkoxy, NH2, NMe2, halogen, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, and -C 1~4 It is substituted with one or more of alkylhydroxy.

[0010] In some embodiments, the present disclosure is directed to a compound of formula II, or a pharmaceutically acceptable salt or stereoisomer thereof: [ka] During the ceremony, X 1 is a linear or branched chain C 1~6 Alkyl, C 3~6 Cycloalkyl, C 6~10 aryl, 5- to 10-membered heteroaryl, 4- to 8-membered heterocycloalkyl; X 1 is unsubstituted or substituted with halogen, linear or branched C 1~6Alkyl, straight or branched chain C 1~6 Heteroalkyl, CF3, CHF2, CMeF2, -O-CHF2, -O-(CH2)2-OMe, OCF3, C 1~6 Alkylamino, -CN, -N(H)C(O)-C 1~6 Alkyl, -OC(O)-C 1~6 Alkyl, -OC(O)-C 1~4 Alkylamino, -C(O)OC 1~6 Alkyl, -COOH, -C 1~6 AlkylC(O)OH, -C 1~6 Alkyl C(O)OC 1~6 Alkyl, NH2, C 1~4 Alkoxy, and C 1~4 substituted with one or more of alkylhydroxy; or X 1 together with the N atom of the carbamate to form a 4- to 8-membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight- or branched-chain -C 1~6 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, -N(H)C(O)-C 1~6 Alkyl, -OC(O)-C 1~6 Alkyl, -C(O)OC 1~6 Alkyl, -COOH, -C 1~6 AlkylC(O)OH, -C 1~6 Alkyl C(O)OC 1~6 Alkyl, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy; X 2 is H, C 3~6 Cycloalkyl, C 6~10 aryl, 5- to 10-membered heteroaryl, or 4- to 8-membered heterocycloalkyl; and X 2 is unsubstituted or a straight or branched chain C 1~6 Alkyl, -C 1~4Alkoxy, NH2, NMe2, halogen, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, and C 1~4 substituted with one or more of alkylhydroxy; L 2 is a covalent bond, linear or branched C 1~6 is alkyl, and L 3 is a covalent bond, linear or branched C 1~6 Alkyl, -O-, -C 1~4 is an alkoxy, R a is H or a straight or branched chain C such as methyl or ethyl 1~4 alkyl, and n is 1 or 2.

[0011] In some embodiments of the compound of Formula II, n is 1.

[0012] In some embodiments, the present disclosure is directed to a compound of formula III, such as formula IVa or IVb, or a pharmaceutically acceptable salt or stereoisomer thereof: [ka] During the ceremony, X 1 is a linear or branched chain C 1~6 Alkyl, C 3~6 Cycloalkyl, C 6~10 aryl, 5- to 10-membered heteroaryl, 4- to 8-membered heterocycloalkyl; X 1 is unsubstituted or substituted with halogen, linear or branched C 1~6 Alkyl, straight or branched chain C 1~6 Heteroalkyl, CF3, CHF2, CMeF2, -O-CHF2, -O-(CH2)2-OMe, OCF3, C 1~6 Alkylamino, -CN, -N(H)C(O)-C 1~6 Alkyl, -OC(O)-C 1~6 Alkyl, -OC(O)-C 1~4 Alkylamino, -C(O)OC 1~6 Alkyl, -COOH, -C1~6 AlkylC(O)OH, -C 1~6 Alkyl C(O)OC 1~6 Alkyl, NH2, C 1~4 Alkoxy, and C 1~4 substituted with one or more of alkylhydroxy; or X 1 together with the N atom of the carbamate to form a 4- to 8-membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight- or branched-chain -C 1~6 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, -N(H)C(O)-C 1~6 Alkyl, -OC(O)-C 1~6 Alkyl, -C(O)OC 1~6 Alkyl, -COOH, -C 1~6 AlkylC(O)OH, -C 1~6 Alkyl C(O)OC 1~6 Alkyl, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy; X 2 is H, C 3~6 Cycloalkyl, C 6~10 aryl, 5- to 10-membered heteroaryl, or 4- to 8-membered heterocycloalkyl; and X 2 is unsubstituted or a straight or branched chain C 1~6 Alkyl, -C 1~4 Alkoxy, NH2, NMe2, halogen, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, and C 1~4 substituted with one or more of alkylhydroxy; L 3 is a covalent bond, linear or branched C 1~6 Alkyl, -O-, -C 1~4 is an alkoxy, R a , R b , R c are, independently of each other, H, straight or branched chain C 1~4alkyl, for example, methyl; and p is 0 or 1.

[0013] In some embodiments, the compound of Formula I is a compound of Formula V, VI, or VII, or a pharmaceutically acceptable salt or stereoisomer thereof: [ka] During the ceremony, w 1 , w 2 , w 3 , w 4 , w 5 one or two of which are independently selected from C, N, S, and O, and the remaining w 1 , w 2 , w 3 , w 4 , w 5 is C, w 6 , w 7 , w 8 , w 9 One or two of the groups are selected from C and O, and the remaining w 6 , w 7 , w 8 , w 9 is C and w 10 , w 11 are independently selected from C and N, and q is 0 or 1; L 1 is a covalent bond, linear or branched C 1~6 is alkyl, and L 2 is a covalent bond, linear or branched C 1~6 is alkyl, R 1 , R 2 , R 3 , R 4 are, independently of each other, H, linear or branched -C 1~6 Alkyl, linear or branched C 1~6 Heteroalkyl, -C 1~4 Alkoxy, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, -C 1~6 Alkylamino, -CN, -OC(O)-C 1~6Alkyl, -N(H)C(O)-C 1~6 Alkyl, -C(O)OC 1~6 Alkyl, -COOH, -C 1~6 AlkylC(O)OH, -C 1~6 Alkyl C(O)OC 1~6 Alkyl, NH2, -C 1~4 alkylhydroxy and halogen such as F, Cl or Br, e.g., F or Cl, or a group of formula -L 3 -X 2 wherein L 3 is a covalent bond, linear or branched C 1~6 Alkyl, -O-, -C 1~4 is an alkoxy group, and X is an alkoxy group. 2 is C 3~6 Cycloalkyl, C 6~10 aryl, 5- to 10-membered heteroaryl, or 4- to 8-membered heterocycloalkyl; and X 2 is unsubstituted or a straight or branched chain C 1~6 Alkyl, -C 1~4 Alkoxy, NH2, NMe2, halogen, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, and C 1~4 substituted with one or more alkylhydroxy groups; R 5 , R 6 , R 7 , R 8 are, independently of each other, H, linear or branched C 1~4 selected from alkyl, such as methyl, and halogen, such as F or Cl, such as F; Z is a straight or branched chain -C 1~6 Alkyl, -C 3~6 cycloalkyl, 4- to 8-membered heterocycloalkyl, and Z is unsubstituted or C 1~4 substituted with alkyl, C6 aryl, C6 aryloxy, 6-membered heteroaryl, or CF3, or Z together with the N atom of the carbamate is unsubstituted, or C 1~4Forms a 4-8 membered heterocycloalkyl substituted with alkyl, C6 aryl, C6 aryloxy, 6 membered heteroaryl or CF3, and q is 0 or 1.

[0014] In some embodiments, the present disclosure is directed to a compound of Formula VIII, e.g., VIIIa, or a pharmaceutically acceptable salt or stereoisomer thereof: [ka] In the formula, R a is H or methyl, and W 1 and W 2 is selected from the following: [ka] [ka] [ka] [ka] [ka] [ka] [ka]

[0015] In a second aspect, the present disclosure relates to a composition comprising a compound according to any one of the embodiments described herein, or a pharmaceutically acceptable salt or stereoisomer thereof.

[0016] In some embodiments, the composition further comprises a pharmaceutically acceptable carrier.

[0017] In some embodiments, the composition further comprises a second therapeutically active agent.

[0018] In a third aspect, the present disclosure is directed to a composition according to any of the embodiments described herein for use in therapy.

[0019] In a fourth aspect, some embodiments relate to the treatment of diseases associated with or caused by GSPT1, particularly cancer of the bladder, bone, brain, breast, cervix, chest, colon, endometrium, esophagus, eye, head, kidney, liver, lymph nodes, lung, upper aerodigestive tract (including nasal cavity and paranasal sinuses, nasopharynx or cavities, oral cavity, oropharynx, larynx, hypopharynx and salivary glands), neck, ovary, pancreas, prostate, rectum, skin, stomach, testicles, throat, uterus, amyloidosis, neuroblastoma, meningioma, hemangiopericytoma, multiple brain metastases, glioblastoma multiforme, glioblastoma, brainstem glioma, malignant brain tumors with poor prognosis, malignant glioma, Recurrent malignant glioma, anaplastic astrocytoma, anaplastic oligodendroglioma, neuroendocrine tumors, e.g., neuroendocrine prostate cancer (NEPC) such as castration-resistant neuroendocrine prostate cancer and pulmonary neuroendocrine tumor (Lu-NET), rectal adenocarcinoma, colorectal cancer (including stage 3 and stage 4 colorectal cancer), unresectable colorectal cancer, metastatic hepatocellular carcinoma, Kaposi's sarcoma, malignant melanoma, malignant mesothelioma, malignant pleural effusion mesothelioma syndrome, peritoneal cancer, papillary serous carcinoma, gynecological sarcoma, soft tissue sarcoma, scleroderma, cutaneous vasculitis, Langerhans cell histiocytosis, leiomyosarcoma, fibrodysplasia ossificans progressiva, hormone-refractory pre-existing Solid tumors and diffuse large B-cell lymphoma (DLBCL), B-cell immunoblastic lymphoma, small non-cleaved cell lymphoma, human lymphotropic virus type 1 (HTLV-1) leukemia / lymphoma, adult T-cell lymphoma, peripheral T-cell lymphoma (PTCL), and leiomyoma, including but not limited to prostate cancer, resected high-risk soft tissue sarcoma, unresectable hepatocellular carcinoma, fallopian tube cancer, androgen-independent prostate cancer, androgen-dependent stage IV non-metastatic prostate cancer, hormone-insensitive prostate cancer, chemotherapy-insensitive prostate cancer, papillary thyroid carcinoma, follicular thyroid carcinoma, medullary thyroid carcinoma, and leiomyoma. CL), cutaneous T-cell lymphoma (CTCL), mantle cell lymphoma (MCL), Hodgkin's lymphoma (HL), non-Hodgkin's lymphoma (NHL), AIDS-related lymphoma, follicular lymphoma, small lymphocytic lymphoma, T-cell / histiocyte-rich large B-cell lymphoma, transformed lymphoma, primary mediastinal (thymic) large B-cell lymphoma, splenic marginal zone lymphoma, Richter's transformation, nodal marginal zone lymphoma, ALK-positive large B-cell lymphoma, indolent lymphoma (e.g., DLBCL, follicular lymphoma, or marginal zone lymphoma), acute myeloid leukemia (AML),The present invention includes a compound of Formulas I-VIII or a pharmaceutically acceptable salt or stereoisomer thereof, or a pharmaceutically acceptable salt thereof, or a composition thereof, as described herein, for use in the treatment of cancers associated with GSPT1, such as blood-borne (liquid) or hematological cancers, including, but not limited to, leukemias, lymphomas, and myelomas, such as acute lymphocytic leukemia (ALL), adult T-cell leukemia, chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), hairy cell leukemia, myelodysplasia, myeloproliferative disorders, chronic myeloid leukemia (CML), acute monocytic leukemia (AMoL), myelodysplastic syndromes (MDS), human lymphotropic virus-1 (HTLV-1) leukemia, mastocytosis, B-cell acute lymphoblastic leukemia, non-Hodgkin's lymphoma, Hodgkin's lymphoma, and multiple myeloma (MM).

[0020] Some embodiments include a compound or composition according to any of the embodiments described herein for use in treating breast cancer.

[0021] Some embodiments include a compound or composition according to any of the embodiments described herein for use in treating lung cancer, e.g., non-small cell lung cancer (e.g., squamous cell lung cancer) and small cell lung cancer.

[0022] Some embodiments include the use of a compound or composition according to any of the embodiments described herein to treat neuroendocrine prostate cancer (NEPC), eg, castration-resistant neuroendocrine prostate cancer.

[0023] Some embodiments include the use of a compound or composition according to any of the embodiments described herein to treat lung neuroendocrine tumors (Lu-NETs).

[0024] Some embodiments include a compound or composition according to any of the embodiments described herein for use in the treatment of acute myeloid leukemia (AML) and multiple myeloma (MM).

[0025] In a fifth aspect, the present disclosure relates to the use of a compound or composition according to any of the embodiments described herein for binding to cereblon, the use comprising administering to a subject a therapeutically effective amount of the composition.

[0026] In some embodiments, the tumor is a cancer of the bladder, bone, brain, breast, cervix, chest, colon, endometrium, esophagus, eye, head, kidney, liver, lymph node, lung, upper aerodigestive tract (including nasal cavity and paranasal sinuses, nasopharynx or cavities, oral cavity, oropharynx, larynx, hypopharynx and salivary glands), neck, ovary, pancreas, prostate, rectum, skin, stomach, testicle, throat, uterus, amyloidosis, neuroblastoma, meningioma, hemangiopericytoma, multiple brain metastases, glioblastoma multiforme, glioblastoma, brainstem glioma, malignant brain tumor with poor prognosis, malignant glioma, recurrent malignant glioma, anaplastic astrocytoma, anaplastic oligodendroglioma, neuroendocrine tumor, e.g., castration Neuroendocrine prostate cancer (NEPC) including resistant neuroendocrine prostate cancer and pulmonary neuroendocrine tumors (Lu-NET), rectal adenocarcinoma, colorectal cancer (including stage 3 and stage 4 colorectal cancer), unresectable colorectal cancer, metastatic hepatocellular carcinoma, Kaposi's sarcoma, malignant melanoma, malignant mesothelioma, malignant pleural effusion mesothelioma syndrome, peritoneal cancer, papillary serous carcinoma, gynecological sarcoma, soft tissue sarcoma, scleroderma, cutaneous vasculitis, Langerhans cell histiocytosis, leiomyosarcoma, fibrodysplasia ossificans progressiva, hormone-refractory prostate cancer, resected high-risk soft tissue sarcoma, unresectable hepatocellular carcinoma, fallopian tube cancer, and androgen-independent Solid tumors and diffuse large B-cell lymphoma (DLBCL), B-cell immunoblastic lymphoma, small non-cleaved cell lymphoma, human lymphotropic virus type 1 (HTLV-1) leukemia / lymphoma, adult T-cell lymphoma, peripheral T-cell lymphoma (PTCL), cutaneous T-cell lymphoma (CTCL), mantle cell lymphoma (MCL), Hodgkin's lymphoma (HLL), and other lymphomas, including but not limited to: prostate cancer, androgen-dependent stage IV non-metastatic prostate cancer, hormone-insensitive prostate cancer, chemotherapy-insensitive prostate cancer, papillary thyroid carcinoma, follicular thyroid carcinoma, medullary thyroid carcinoma, and leiomyoma. lymphoma (HL), non-Hodgkin's lymphoma (NHL), AIDS-related lymphoma, follicular lymphoma, small lymphocytic lymphoma, T-cell / histiocyte-rich large B-cell lymphoma, transformed lymphoma, primary mediastinal (thymic) large B-cell lymphoma, splenic marginal zone lymphoma, Richter's transformation, nodal marginal zone lymphoma, ALK-positive large B-cell lymphoma, indolent lymphoma (e.g., DLBCL, follicular lymphoma, or marginal zone lymphoma), acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), adult T-cell leukemia, chronic lymphocytic leukemia (CLL),The present invention includes the use of a composition according to any of the embodiments described herein to treat cancers associated with GSPT1, such as blood-borne (liquid) or hematological cancers, including but not limited to leukemias, lymphomas, and myelomas, such as small lymphocytic lymphoma (SLL), hairy cell leukemia, myelodysplasia, myeloproliferative disorders, chronic myeloid leukemia (CML), acute monocytic leukemia (AMoL), myelodysplastic syndromes (MDS), human lymphotropic virus-1 (HTLV-1) leukemia, mastocytosis, B-cell acute lymphoblastic leukemia, non-Hodgkin's lymphoma, Hodgkin's lymphoma, and multiple myeloma (MM).

[0027] Some embodiments include the use of a compound or composition according to any of the embodiments described herein to treat breast cancer.

[0028] Some embodiments include the use of a compound or composition according to any of the embodiments described herein to treat lung cancer, e.g., non-small cell lung cancer (e.g., squamous cell lung cancer) and small cell lung cancer.

[0029] Some embodiments include the use of a compound or composition according to any of the embodiments described herein to treat neuroendocrine prostate cancer, eg, castration-resistant neuroendocrine prostate cancer (NEPC).

[0030] Some embodiments include the use of a compound or composition according to any of the embodiments described herein to treat lung neuroendocrine tumors (Lu-NETs).

[0031] Some embodiments include the use of a compound or composition according to any of the embodiments described herein to treat acute myeloid leukemia (AML) and multiple myeloma (MM).

[0032] In a sixth aspect, the present disclosure relates to a method of treating cancer in a subject, the method comprising administering to the subject a therapeutically effective amount of a compound or composition of any of the embodiments described herein.

[0033] In some embodiments, the methods involve a compound according to any of the embodiments described herein, or a pharmaceutically acceptable salt or stereoisomer thereof, that binds to cereblon.

[0034] In a seventh aspect, the present disclosure relates to a method of treating Myc-driven cancer in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a compound or composition described herein. In an eighth aspect, the present disclosure relates to a method of degrading GSPT1 in a subject suffering from cancer, the method comprising administering to the subject a therapeutically effective amount of a compound or composition described herein. In a ninth aspect, the present disclosure relates to a method for reducing the level of GSPT1 in a subject suffering from cancer, the method comprising administering to the subject a therapeutically effective amount of a compound or composition described herein. [Brief explanation of the drawings]

[0035] [Figure 1A] These results show that treatment of cells with 0.3 μM of compound 10 induced complete degradation of GSPT1, whereas no induction of degradation of IKZF1, IKZF3, SALL4, or CK1α was observed at concentrations up to 30 μM. [Figure 1B] Based on mass spectrometry-based proteomic analysis of cancer cell lines treated with compound 10, we show that GSPT1 is the statistically most significantly downregulated protein (x-axis represents protein fold change (log2) and y-axis represents p-value, which assesses whether the observation is the result of a change or a random event; a smaller p-value indicates stronger evidence of a real change). [Figure 2A]NSCLC cell lines expressing high levels of N-Myc (NCI-H1155, represented by closed triangles; ABC-1, represented by closed diamonds) are shown to be highly sensitive to treatment with compound 10 when compared with cell lines expressing low levels of N-Myc (EBC-1, represented by open triangles; NCI-H2023, represented by open circles). GSPT1 was degraded by compound 10 with a DC50 of 3 nM and 22 nM after 6 hours of treatment in high N-Myc NCI-H1155 and ABC-1 cells, respectively (x-axis represents μM concentration of compound 10, y-axis represents % viability). Complete degradation of GSPT1 was observed in both cell lines. [Figure 2B] 1 shows that compound 10 degrades GSPT1 in a concentration-dependent manner (x-axis represents the μM concentration of compound 10, and y-axis represents the relative level of GSPT1). [Figure 3A] Oral administration of compound 10 in an N-Myc-driven mouse xenograft model using the human cell line NCI-H1155 resulted in tumor growth inhibition (no weight loss was observed). At a dose of 1 mg / kg once daily, tumor growth was suppressed for 2 weeks. Administration of 3 mg / kg once daily or 6 mg / kg for 5 days with a 9-day rest period reduced tumor size, making it undetectable by day 8 and remaining undetectable until the end of the study on day 21. (The x-axis represents days after treatment initiation [days], and the y-axis represents tumor volume [mm3], mean ± SEM. Open circles (O): vehicle, PO, QD; closed squares (☐): 1 mg / kg PO, QD; closed triangles (☐): 3 mg / kg PO, QD; closed inverted triangles (☐): 6 mg / kg PO, 5 on-9 off; closed diamonds (☐): gemcitabine 40 mg / kg IP, Q4Dx5.) [Figure 3B] Shows complete degradation of GSPT1 in tumors of mice treated with compound 10 at all three dose levels compared to mice treated with vehicle control (from left to right: vehicle, 1 mg / kg, 3 mg / kg, 6 mg / kg). [Figure 3C]Oral administration of compound 10 in an N-Myc-driven mouse xenograft model using the human cell line NCI-H1770 resulted in tumor growth inhibition (without observed weight loss). Administration of 3 mg / kg once daily or 6 mg / kg for 5 days followed by a 9-day rest period reduced tumor size and remained undetectable until the end of the study. (The x-axis represents days after treatment initiation [days], and the y-axis represents tumor volume [mm3], mean ± SEM. Open circles (O): vehicle, PO, QD; closed triangles (▴), 3 mg / kg PO, QD; closed inverted triangles (▴), 6 mg / kg PO, 5 on-9 off; closed diamonds (▴), cisplatin 6 mg / kg IP, QWx3.) [Figure 3D] Oral administration of compound 10 in an N-Myc-driven mouse xenograft model using the human cell line NCI-H526 resulted in tumor growth inhibition (without observed weight loss). When administered at 3 mg / kg once daily or at 6 mg / kg for 5 days followed by a 9-day rest period, tumor size decreased and remained undetectable until the end of the study. (The x-axis represents the number of days since the start of treatment [days], and the y-axis represents tumor volume [mm3], mean ± SEM. Open circles (O): vehicle, PO, QD; closed triangles (▴), 3 mg / kg PO, QD; closed inverted triangles (▴), 6 mg / kg PO, 5 on-9 off; closed diamonds (▴), cisplatin 6 mg / kg IP, QWx3.) DETAILED DESCRIPTION OF THE INVENTION

[0036] Unless otherwise specified, the following general definitions apply to all compounds of this disclosure as described.

[0037] As used herein, the term "compounds of the disclosure" refers to any of the compounds represented by Formulas I-VIII (including pharmaceutically acceptable salts and stereoisomers thereof), and the specific examples disclosed herein. A reference herein to any compound of any formula also includes a pharmaceutically acceptable salt or stereoisomer thereof.

[0038] A "subject" to which administration is contemplated includes, but is not limited to, a human (e.g., a pediatric subject (e.g., an infant, child, adolescent) or an adult subject (e.g., a young adult, a middle-aged adult, or an elderly adult)) and / or a non-human animal, e.g., a mammal such as a primate (e.g., a cynomolgus monkey, a rhesus monkey), a cow, a pig, a horse, a sheep, a goat, a rodent, a cat, and / or a dog. In certain embodiments, the subject is a human. In certain embodiments, the subject is a non-human animal. The terms "patient" and "subject" are used interchangeably herein.

[0039] "Independently of each other" is understood to mean that when a radical occurs more than once in any compound, its definition in each occurrence is independent of the other occurrences.

[0040] Additionally, dashed lines (or waves across bonds) or -C 1~4 A solid line without a bond, such as an alkyl, is understood to indicate the site of attachment of the residue (ie, subformula).

[0041] It is further understood that the abbreviations "C" and "N" represent all possible degrees of saturation and do not generally result in radicals, nitrenes, or carbenes, i.e., N includes -NH- and -N=, and C includes -CH2- and =CH-. Furthermore, the substituent R x "C" as an atom in an aromatic or heteroaromatic ring includes =CH- and =CR x -Includes.

[0042] The term "saturated" in reference to a ring system refers to a ring that has no double or triple bonds. The term "partially unsaturated" in reference to a ring system refers to a ring that contains at least one double or triple bond, but does not contain an aromatic ring.

[0043] The term "aromatic" refers to a monocyclic or polycyclic (e.g., bicyclic) ring system exhibiting partial or complete conjugation or delocalization of electrons. Aromatic monocyclic rings, such as aryl or heteroaryl rings, as defined herein include phenyl, pyridinyl, furyl, and the like. Aromatic polycyclic rings, such as aryl or heteroaryl rings, as defined herein, refer to ring systems in which at least one ring is aromatic, and thus include (i) aromatic ring systems in which an aromatic ring is fused to one or more aromatic rings, such as naphthyl, indolyl, benzimidazolyl, and the like (also referred to as fully aromatic ring systems), and (ii) aromatic ring systems in which an aromatic ring is fused to one or more non-aromatic rings, such as indanyl, indenyl, phthalimidyl, naphthymidyl, phenanthridinyl, tetrahydronaphthyl, 1,4-dihydronaphthyl, and the like (also referred to as partially aromatic ring systems).

[0044] The term "non-aromatic" refers to (i) fully saturated rings such as monocyclic rings, e.g., cyclohexyl, and bicyclic rings, e.g., tetrahydronaphthyl, and (ii) partially unsaturated rings such as monocyclic rings, e.g., cyclohexenyl, and bicyclic rings, e.g., 1,4-dihydronaphthyl.

[0045] "C 6~10 The term "aryl" refers to any fully aromatic C group having 6, 7, 8, 9, or 10 ring atoms. 6~10 Aryl and partially aromatic C 6~10 This includes both aryl and monocyclic and fused bicyclic rings. 6~10 Examples of aryl include phenyl (all aromatic C6 aryl), naphthyl (all aromatic C 10 Aryl) and partially aromatic C 6~10 Examples of aryl include indenyl (partially aromatic C9 aryl), 2,3-dihydroindenyl (partially aromatic C9 aryl), 1,2,3,4-tetrahydronaphthyl (partially aromatic C 10 aryl). 1 In some embodiments, C 6~10 Aryl is phenyl, 2,3-dihydroindenyl. Group X 2In some embodiments, C 6~10 Aryl is phenyl. -C 1~6 Alkyl-C 6~10 The term "aryl" refers to -L 2 -X 1 - or L 3 -X 2 - refers to, in which L 2 , L 3 is C 1~6 is an alkyl group, and X 1 , X 2 is C 6~10 C as defined herein because it is aryl. 1~6 C bonded to the adjacent group via an alkyl group 6~10 Refers to aryl. -C 1~6 Alkoxy-C 6~10 The term "aryl" refers to -L 2 -X 1 - or L 3 -X 2 - refers to, in which L 2 , L 3 is C 1~6 is an alkoxy group, and X 1 , X 2 is C 6~10 C as defined herein because it is aryl. 1~6 C bonded to the adjacent group via an alkoxy group 6~10 Refers to aryl. -OC 6~10 aryl" or "C 6~10 The term "aryloxy" refers to -L 2 -X 1 - or L 3 -X 2 - refers to, in which L 2 , L 3 is -O- and X 1 , X 2 is C 6~10 Being aryl, C is bonded to the adjacent group via an -O- group. 6~10 Refers to aryl. C 6~10 The aryl group may be unsubstituted or may be C 1~4 Alkyl (methyl, ethyl, t-butyl, etc.), fluorinated C 1~4Alkyl (-CF3, -C(CH3)F2, etc.), C 1~4 Alkoxy (methoxy, ethoxy, etc.), fluorinated C 1~4 It may be substituted with alkoxy (such as -OCF3, -OCHF2), CN, -N(Me)2, halogen (such as F, Cl or Br, for example, F or Cl).

[0046] X 1 In some embodiments, C 6~10 An aryl group is a wholly aromatic ring system, e.g., unsubstituted or C 1~4 Alkyl (methyl, ethyl, t-butyl, etc.), fluorinated C 1~4 Alkyl (e.g., -C(CH3)F2), C 1~4 Alkoxy (methoxy, ethoxy, etc.), fluorinated C 1~4 Refers to phenyl substituted with alkoxy (such as -OCF3, -OCHF2), CN, or halogen (such as F or Cl). X 1 In some embodiments, C 6~10 An aryl group is a partially aromatic ring system, e.g., unsubstituted or C 1~4 It refers to 2,3-dihydroindenyl substituted with alkyl (such as methyl, ethyl, t-butyl) or halogen (such as F or Cl).

[0047] X 2 In some embodiments, C 6~10 An aryl group is a wholly aromatic ring system, e.g., unsubstituted or C 1~4 Alkyl (methyl, ethyl, etc.), C 1~4 It refers to phenyl substituted with alkoxy (such as methoxy, ethoxy, etc.), halogen (such as F, Cl or Br, for example F or Cl, for example F).

[0048] The term "5-10-membered heteroaryl" refers to a fully or partially aromatic ring system in the form of a monocycle or fused bicycles having 5, 6, 7, 8, 9, 10 ring atoms selected from C, N, O, and S, such as C, N, and O, or C, N, and S, where the number of N atoms is, for example, 0, 1, 2, or 3, and the number of O and S atoms is, respectively, 0, 1, or 2. In some embodiments, 5-10-membered heteroaryl refers to an all-aromatic ring system having 5, 6, 7, 8, 9, 10, e.g., 6, such as 5 or 6, ring atoms selected from C and N, where the number of N atoms is 1, 2, or 3, such as 1 or 2. In some embodiments, 5-10-membered heteroaryl refers to an all-aromatic ring system having 5, 6, 7, 8, 9, 10, e.g., 5, such as 5 or 6, ring atoms selected from C, N, O, and S, where the number of N, S, and O atoms are each independently 0, 1, or 2. In some embodiments, the total number of N, S, and O atoms is 2. In some embodiments, 5-10-membered heteroaryl refers to a fully aromatic ring system having 5 ring atoms selected from C, N, and S, and the number of N and S atoms is each independently 0 or 1. In some embodiments, the total number of N and S atoms is 2. In some embodiments, 5-10-membered heteroaryl refers to a fully aromatic ring system having 6 ring atoms selected from C and N, and the number of N atoms is 1 or 2. In other embodiments, 5-10-membered heteroaryl refers to a partially aromatic ring system having 9 or 10 ring atoms selected from C, N, and O, and the number of O atoms is 1, 2, or 3, such as 1 or 2, and the number of N atoms is 1 or 2, such as 1.In some embodiments, examples of "5- to 10-membered heteroaryl" include furyl, imidazolyl, isoxazolyl, oxazolyl, pyrazinyl, pyrazolyl (pyrazyl), pyridazinyl, pyridinyl, pyrimidinyl, pyrrolyl, thiophenyl, thiazolyl, thienyl, indolyl, quinazolinyl, oxazolinyl, isoxazolinyl, indazolinyl, isothiazolyl, 1,3-benzodioxolyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, benzodihydropyran, 1,2,3,4-tetrahydronaphthyl, 2,3-dihydroindenyl, and the like. In some embodiments, examples of "5- to 10-membered heteroaryl" include 5-membered heteroaryl (such as isothiazole), 6-membered heteroaryl (such as pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl), 9-membered heteroaryl (such as 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine), and 10-membered heteroaryl (such as benzodihydropyran (chroman), dihydropyrano-pyridine). 1~6 The term "5-10 membered alkyl heteroaryl" refers to -L 2 -X 1 - or L 3 -X 2 - refers to, in which L 2 , L 3 is C 1~6 is an alkyl group, and X 1 , X 2 is a 5- to 10-membered heteroaryl, and therefore is C as defined herein. 1~6 -C refers to a 5- to 10-membered heteroaryl bonded to the adjacent group via an alkyl group. 1~6 The term "alkoxy 5-10 membered heteroaryl" refers to -L 2 -X1 - or L 3 -X 2 - refers to, in which L 2 , L 3 is C 1~6 is an alkoxy group, and X 1 , X 2 is a 5- to 10-membered heteroaryl, and therefore is C as defined herein. 1~6 The term "-O-5-10 membered heteroaryl" refers to a 5- to 10-membered heteroaryl that is attached to its adjacent group via an alkoxy group. 2 -X 1 - or L 3 -X 2 - refers to, in which L 2 , L 3 is -O- and X 1 , X 2 is a 5- to 10-membered heteroaryl, and therefore refers to a 5- to 10-membered heteroaryl bonded to the adjacent group via an -O- group. The 5- to 10-membered heteroaryl group may be unsubstituted or 1~4 Alkyl (methyl, ethyl, t-butyl, etc.), fluorinated C 1~4 Alkyl (-CF3, -C(CH3)F2, etc.), C 1~4 Alkoxy (methoxy, ethoxy, etc.), fluorinated C 1~4 It can be substituted with alkoxy (such as -OCF3, -OCHF2), CN, -N(Me)2, halogen (such as F, Cl, or Br, e.g., F or Cl). In some embodiments, the 5- to 10-membered heteroaryl group is unsubstituted or C 1~4 Alkyl (methyl, ethyl, t-butyl, etc.), fluorinated C 1~4 Alkyl (such as -CF3), C 1~4 It may be substituted with alkoxy (such as methoxy, ethoxy, etc.), halogen (such as F or Cl).

[0049] X 1In some embodiments of X, the 5-10 membered heteroaryl refers to a fully aromatic ring system having 5 ring atoms selected from C, N, and S, where the number of N and S atoms is independently 0 or 1, e.g., 1; a fully aromatic ring system having 6 ring atoms selected from C and N, where the number of N atoms is 1 or 2; or a partially aromatic ring system having 9 or 10 ring atoms selected from C, N, and O, where the number of O atoms is 1 or 2, and the number of N atoms is 1. 1 In some embodiments of the formula, 5-10 membered heteroaryl refers to isothiazole, phenyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine.

[0050] X 2 In some embodiments of X, 5-10 membered heteroaryl refers to an all aromatic ring system having 6 ring atoms selected from C and N, where the number of N atoms is 1 or 2, such as 1. 2 In some embodiments of the formula, 5-10 membered heteroaryl refers to pyridinyl.

[0051] "C 3-8 The term "cycloalkyl" refers to a non-aromatic, i.e., saturated or partially unsaturated, alkyl ring system containing 3, 4, 5, 6, 7, or 8 carbons, e.g., monocyclic, fused bicyclic, bridged bicyclic, or spiro bicyclic rings. 3~6 The term "cycloalkyl" refers to a non-aromatic, i.e., saturated or partially unsaturated, alkyl ring system containing 3, 4, 5, or 6 carbons, e.g., monocyclic, fused bicyclic, bridged bicyclic, or spiro bicyclic rings. 3-8Examples of "cycloalkyl" include monocyclic rings such as cyclopropyl, cyclobutyl, cyclopentyl, and cyclohexyl, bridged bicyclic rings such as bicyclo[1.1.1]pentyl and bicyclo[2.1.1]hexyl, and fused bicyclic rings such as bicyclo[3.1.0]hexyl. 3~6 The cycloalkyl group may be unsubstituted or may be C 1~4 Alkyl (methyl, ethyl, t-butyl, etc.), fluorinated C 1~4 Alkyl (-CF3, -C(CH3)F2, etc.), C 1~4 Alkoxy (methoxy, ethoxy, etc.), fluorinated C 1~4 It may be substituted with alkoxy (such as -OCF3, -OCHF2), CN, -N(Me)2, halogen (such as F, Cl, or Br, e.g., F or Cl). In some embodiments, C 3~6 The cycloalkyl group may be unsubstituted or may contain, for example, one or more C 1~4 It may be substituted by alkyl, such as methyl, and halogen, such as F. The term "-C 1~4 Alkyl-C 3~6 "Cycloalkyl" is -L 2 -X 1 - or L 3 -X 2 - refers to, in which L 2 , L 3 is C 1~4 is an alkyl group, and X 1 , X 2は C as defined herein 3~6 cycloalkyl, as defined herein. 1~6 C bonded to the adjacent group via an alkyl group 3~6 Refers to cycloalkyl. -OC 3~6 The term "cycloalkyl" refers to -L 2 -X 1 - or L 3 -X 2 - refers to, in which L 2 , L 3 is -O- and X 1 , X 2 is defined herein as C 3~6 C is a cycloalkyl and is bonded to an adjacent group via -O-3~6 Refers to cycloalkyl. -C 1~4 Alkoxy-C 3~6 The term "cycloalkyl" refers to -L 2 -X 1 - or L 3 -X 2 - refers to, in which L 2 , L 3 is C 1~4 is an alkoxy group, and X 1 , X 2 is defined herein as C 3~6 cycloalkyl, as defined herein. 1~6 C bonded to adjacent groups via an alkoxy group 3~6 Refers to cycloalkyl. X 1 In some embodiments, C 3~6 Cycloalkyl refers to cyclopropyl, cyclopentyl, and cyclohexyl. X 2 In some embodiments, C 3~6 Cycloalkyl refers to cyclopropyl, cyclobutyl.

[0052] The term "4- to 8-membered heterocycloalkyl" refers to a non-aromatic, i.e., saturated or partially unsaturated ring system having 4, 5, 6, 7, or 8 ring atoms (at least one of which is a heteroatom), the ring atoms being selected from C, N, O, and S, such as C, N, and O, where the number of N atoms is 0, 1, or 2 and the number of O atoms and S atoms is 0, 1, or 2, respectively. In some embodiments, the term "4- to 8-membered heterocycloalkyl" includes saturated or partially unsaturated monocyclic, fused bicyclic, bridged bicyclic, or spiro bicyclic rings. In some embodiments, the term "4- to 8-membered heterocycloalkyl" includes fully saturated or partially unsaturated monocyclic and bridged bicyclic rings. Examples of 4- to 8-membered heterocycloalkyl groups include azetidinyl, oxetanyl, pyrrolidinyl, tetrahydrofuranyl, tetrahydrothiopyranyl, dihydropyranyl, tetrahydropyranyl, 1,3-dioxolanyl, 1,4-dioxanyl, 1,4-oxathianyl, 1,4-dithianyl, 1,3-dioxanyl, 1,3-dithianyl, piperazinyl, thiomorpholinyl, piperidinyl, morpholinyl, azabicyclo[2.2.1]heptan-5-yl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl, and the like. The 4- to 8-membered heterocycloalkyl groups are unsubstituted or C 1~4 Alkyl (methyl, ethyl, etc.), C 1~4 It may be substituted with alkoxy (such as methoxy or ethoxy), halogen (such as F, Cl or Br, for example F or Cl).

[0053] In some embodiments, the group X 1 The 4-8 membered heterocycloalkyl represented by the formula (I) is a non-aromatic ring system having 5 or 6 ring atoms, at least one of which is a heteroatom selected from N and O, the number of N atoms being 1 or 2, and the number of O atoms being 0, 1, or 2, e.g., a non-aromatic 6 membered ring system having 1 or 2 N atoms, such as piperidine. In some embodiments, the N atom together with the group X in the form of a carbamate. 1The 4-8 membered heterocycloalkyl formed by is a non-aromatic ring system having 5 or 6 ring atoms, at least one of which is a heteroatom selected from N and O, the number of N atoms being 1 or 2, and the number of O atoms being 0, 1, or 2, e.g., a non-aromatic ring system having 5 or 6 ring atoms including 1 or 2 N atoms. Examples include pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, and N-methylpiperazinyl. In some embodiments, X 2 A 4-8 membered heterocycloalkyl having 4, 5, 6, 7, or 8 ring atoms is a non-aromatic ring system having 4, 5, 6, 7, or 8 ring atoms, at least one of which is a heteroatom selected from N and O, where the number of N atoms is 1 or 2 and the number of O atoms is 0, 1, or 2. In some embodiments, a 4-8 membered heterocycloalkyl includes a 4 membered heterocycloalkyl (having at least one heteroatom selected from N and O, where the number of N atoms is 1 or 2 and the number of O atoms is 0 or 1, e.g., azetidinyl, oxetanyl, unsubstituted, or C, such as, e.g., methyl). 1~4 5-membered heterocycloalkyl (having 1 or 2 N atoms and containing one or more C atoms, e.g., pyrrolidinyl, unsubstituted or substituted with one or more C atoms, e.g., methyl) 1~4 6-membered heterocycloalkyl (having N and O atoms and unsubstituted or substituted by one or more C atoms, such as morpholinyl, piperazinyl, piperidinyl, dioxanyl, etc.) 1~4 substituted by alkyl (such as methyl), halogen, for example F); 7-membered heterocycloalkyl having N and O atoms, such as one N- and one O-atom, such as 2-oxa-5-azabicyclo[2.2.1]heptan-5-yl, 1,4-diazabicyclo[3.2.1]octan-4-yl, 3-methyl-3-azabicyclo[3.1.0]hexan-1-yl; 8-membered heterocycloalkyl having N and O atoms, such as one N- and one O-atom, such as 8-oxa-3-azabicyclo[3.2.1]octan-3-yl.

[0054] "C 1~4The term "alkyl 4-8 membered heterocycloalkyl" refers to -L 2 -X 1 - or L 3 -X 2 - refers to, in which L 2 , L 3 is C1-4 alkyl, and X 1 , X 2 is a 4- to 8-membered heterocycloalkyl as defined herein. Thus, a 4- to 8-membered heterocycloalkyl is a 4- to 8-membered heterocycloalkyl as defined herein. 1~4 and is linked to an adjacent group via an alkyl group. In some embodiments, the alkyl can be C1, resulting in -(CH2)-(4- to 8-membered heterocycloalkyl), or C2, resulting in -(CH2)2-(4- to 8-membered heterocycloalkyl), or C3, resulting in -(CH2)3-(4- to 8-membered heterocycloalkyl), or C4, resulting in -(CH2)4-(4- to 8-membered heterocycloalkyl). Examples include -(CH2)-morpholinyl, -(CH2)2-morpholinyl, -(CH2)3-morpholinyl, -(CH2)4-morpholinyl, -(CH2)-piperazinyl, -(CH2)2-N-methyl-piperazinyl, -(CH2)3-piperazinyl, or -(CH2)4-piperazinyl.

[0055] "-C 1~4 The term "alkoxy 4-8 membered heterocycloalkyl" refers to -L 2 -X 1 - or L 3 -X 2 - refers to, in which L 2 , L 3 is C 1~4 is an alkoxy group, and X is an alkoxy group. 1 , X 2 is a 4- to 8-membered heterocycloalkyl as defined herein. Accordingly, a 4- to 8-membered heterocycloalkyl is a C 1~4 In some embodiments, C is bonded to the adjacent group through an alkoxy group. 1~4 Alkoxy is a C1 group resulting in -(O-CH2)-(4-8 membered heterocycloalkyl), or -(O-CH 2)2It can be C2, resulting in -(4-8 membered heterocycloalkyl), or C3, resulting in -(O-CH2)3-(4-8 membered heterocycloalkyl). Examples include -(O-CH2)-(N-morpholinyl), -(O-CH2)2-(N-morpholinyl).

[0056] The term "-O-(4- to 8-membered heterocycloalkyl)" refers to -L 2 -X 1 - or L 3 -X 2 - refers to, in which L 2 , L 3 is -O- and X 1 , X 2 is a 4- to 8-membered heterocycloalkyl, as defined herein. Thus, a 4- to 8-membered heterocycloalkyl is bonded to an adjacent group through the -O- atom. Examples include -O-morpholinyl, -O-piperazinyl, -O-pyrrolidinyl, and the like.

[0057] The term "halogen" or "hal" as used herein can be fluoro, chloro, bromo or iodo, such as fluoro, chloro or bromo, eg fluoro or chloro.

[0058] "C 1~4 Alkyl" and "C 1~6 The term "alkyl" refers to a fully saturated branched or unbranched hydrocarbon moiety having 1, 2, 3, or 4 and 1, 2, 3, 4, 5, or 6 carbon atoms, respectively. Representative examples of alkyl include, but are not limited to, methyl, ethyl, n-propyl, iso-propyl, n-butyl, sec-butyl, iso-butyl, tert-butyl, n-pentyl, iso-pentyl, neopentyl, n-hexyl, iso-hexyl, or neohexyl.

[0059] "C 1~6The term "heteroalkyl" refers to an alkyl as defined having 1, 2, 3, 4, 5, or 6 carbon atoms, in which at least one carbon atom is replaced with a heteroatom, such as N, O, or S. A heteroatom may be one or two C 1~6 It is understood that it may be further substituted with alkyl. Examples include -(CH2)2-O-Me, -(CH2)3-O-Me, -(CH2)2-O-CH2Me, -(CH2)2-NMe2, -(CH2)-NMe2, -(CH2)2-NEt2, -(CH2)-NEt2, and the like.

[0060] "C 1~4 The term "alkylamino" refers to a fully saturated branched or unbranched C 1~4 alkyl, which refers to at least one, for example only one, amino, alkylamino or dialkylamino group, such as NH, HN(C 1~4 alkyl) or N(C 1~4 alkyl)2. Therefore, C 1~4 Alkylamino is C 1~4 Alkylamino, C 1~4 Alkyl-(C 1~4 Alkyl)amino, C 1~4 Alkyl-(C 1~4 (dialkyl)amino. Examples include, but are not limited to, methylaminomethyl, dimethylammoniummethyl, aminomethyl, dimethylaminoethyl, aminoethyl, methylaminoethyl, n-propylamino, isopropylamino, n-butylamino, sec-butylamino, isobutylamino, and tert-butylamino.

[0061] "C 1~4 The term "alkoxy" refers to an unsubstituted or substituted alkyl chain attached through an oxygen atom to the remainder of the molecule, particularly methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, iso-butoxy, and t-butoxy.

[0062] Based on the definitions provided throughout this application, one of ordinary skill in the art will know which combinations are synthetically feasible and practical, for example, typically combinations of groups connected to several heteroatoms directly bonded to each other, such as -SN= of isothiazole, which is a synthetically feasible combination, although -OO- is not contemplated.

[0063] In a first aspect, the disclosure provides a compound of Formula I, or a pharmaceutically acceptable salt or stereoisomer thereof: [ka] During the ceremony, X 1 is a linear or branched chain C 1~6 Alkyl, C 3~8 Cycloalkyl, C 6~10 aryl, 5- to 10-membered heteroaryl, 4- to 8-membered heterocycloalkyl; X 1 is unsubstituted or halogen, straight or branched chain C 1~6 Alkyl, straight or branched chain C 1~6 Heteroalkyl, CF3, CHF2, CMeF2, -O-CHF2, -O-(CH2)2-OMe, OCF3, C 1~6 Alkylamino, -CN, -N(H)C(O)-C 1~6 Alkyl, -OC(O)-C 1~6 Alkyl, -OC(O)-C 1~4 Alkylamino, -C(O)OC 1~6 Alkyl, -COOH, -C 1~6 AlkylC(O)OH, -C 1~6 Alkyl C(O)OC 1~6 Alkyl, NH2, C 1~4 Alkoxy, C 1~4 Alkylhydroxy, -CH2F, -N(H)C(O)-OC 1~6 substituted with one or more of alkyl, and C(OH)(CF3); or X 1together with the N atom of the carbamate to form a 4- to 8-membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight- or branched-chain -C 1~6 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, -N(H)C(O)-C 1~6 Alkyl, -OC(O)-C 1~6 Alkyl, -C(O)OC 1~6 Alkyl, -COOH, -C 1~6 AlkylC(O)OH, -C 1~6 Alkyl C(O)OC 1~6 Alkyl, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy; X 2 is H, C 3~6 Cycloalkyl, C 6~10 aryl, 5- to 10-membered heteroaryl, or 4- to 8-membered heterocycloalkyl; and X 2 is unsubstituted or a straight or branched chain C 1~6 Alkyl, -C 1~4 Alkoxy, NH2, NMe2, halogen, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, and C 1~4 substituted with one or more of alkylhydroxy; L 1 is a covalent bond, linear or branched C 1~6 is alkyl, L 2 is a covalent bond, linear or branched C 1~6 is alkyl, L 3 is a covalent bond, linear or branched C 1~6 Alkyl, -O-, or -C 1~4 Alkoxy, straight or branched chain C 1~6 The alkyl is unsubstituted or substituted with one or more halogens.

[0064] In some embodiments, X1 is a linear or branched chain C 1~6 Alkyl, C 3~6 Cycloalkyl, C 6~10 aryl, 5- to 10-membered heteroaryl, 4- to 8-membered heterocycloalkyl; X 1 is unsubstituted or substituted with halogen, linear or branched C 1~6 Alkyl, straight or branched chain C 1~6 Heteroalkyl, CF3, CHF2, CMeF2, -O-CHF2, -O-(CH2)2-OMe, OCF3, C 1~6 Alkylamino, -CN, -N(H)C(O)-C 1~6 Alkyl, -OC(O)-C 1~6 Alkyl, -OC(O)-C 1~4 Alkylamino, -C(O)OC 1~6 Alkyl, -COOH, -C 1~6 AlkylC(O)OH, -C 1~6 Alkyl C(O)OC 1~6 Alkyl, NH2, C 1~4 Alkoxy, and C 1~4 substituted with one or more of alkylhydroxy; or X 1 together with the N atom of the carbamate to form a 4- to 8-membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight- or branched-chain -C 1~6 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, -N(H)C(O)-C 1~6 Alkyl, -OC(O)-C 1~6 Alkyl, -C(O)OC 1~6 Alkyl, -COOH, -C 1~6 AlkylC(O)OH, -C 1~6 Alkyl C(O)OC 1~6 Alkyl, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy; X 2 is H, C 3~6 Cycloalkyl, C6~10 aryl, 5- to 10-membered heteroaryl, or 4- to 8-membered heterocycloalkyl; and X 2 is unsubstituted or a straight or branched chain C 1~6 Alkyl, -C 1~4 Alkoxy, NH2, NMe2, halogen, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, and C 1~4 substituted with one or more of alkylhydroxy; L 1 is a covalent bond, linear or branched C 1~6 is alkyl, L 2 is a covalent bond, linear or branched C 1~6 is alkyl, L 3 is a covalent bond, linear or branched C 1~6 Alkyl, -O-, -C 1~4 It is an alkoxy.

[0065] In some embodiments of the compound of Formula I, L 1 is a linear or branched chain C 1~6 In some embodiments of the compounds of Formula I, L is alkyl. 1 is a straight or branched chain C such as -CH2- or -CH(CH3)- 1~4 It is alkyl.

[0066] In some embodiments of the compound of Formula I, L 2 is a covalent bond. In some embodiments of the compounds of Formula I, L 2 is a straight or branched chain C 1~4 Straight or branched chain C such as alkyl 1~6 Alkyl, for example -CH2- or -CH(CH3)-.

[0067] In some embodiments of the compound of Formula I, L 3 is a covalent bond. In some embodiments, L 3 is a linear or branched chain C 1~4 In some embodiments of the compounds of Formula I, L is alkyl. 3In some embodiments of the compound of Formula I, L 3 is a straight or branched chain C such as -O-CH2-, -O-CH2-CH2- 1~4 It is an alkoxy.

[0068] In some embodiments of the compound of Formula I, L 1 is -CH2-, and L 2 is a covalent bond. In some embodiments of the compounds of Formula I, L 1 is -CH2-, and L 2 is —CH—. In some embodiments of the compound of Formula I, L 1 is -CH2-, and L 2 is -CH(CH2)-.

[0069] In some embodiments of the compound of Formula I, L 1 is -CH2-, and L 2 is a covalent bond, and L 3 is a covalent bond. In some embodiments of the compounds of Formula I, L 1 is -CH2-, and L 2 is a covalent bond, and L 3 is —CH—. In some embodiments of the compound of Formula I, L 1 is -CH2-, and L 2 is a covalent bond, and L 3 is —O—. In some embodiments of the compound of Formula I, L 1 is -CH2-, and L 2 is a covalent bond, and L 3 is —O—CH—. In some embodiments of the compound of Formula I, L 1 is -CH2-, and L 2 is a covalent bond, and L 3 is -O-CH2-CH2-.

[0070] In some embodiments of the compound of Formula I, X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy; or X 1 together with the N atom of the carbamate to form a 5-6 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy.

[0071] In some embodiments of the compound of Formula I, X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCHF2, CN, and C 1~4 alkoxy; or X 1 together with the N atom of the carbamate to form a 6-membered heterocycloalkyl, which is unsubstituted or 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2 and C 1~4 substituted with one or more of alkoxy.

[0072] In some embodiments of the compound of Formula I, X 1 is a straight or branched chain -C 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy; or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, N-methylpiperazinyl, which may be unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, or C 1~4 substituted with one or more of alkoxy.

[0073] In some embodiments of the compound of Formula I, X 1 is a straight or branched chain -C 1~6alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -OCF3, OCHF2, CN, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, piperazinyl, which may be unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0074] In some embodiments of the compound of Formula I, X 2 is H, C 3~6 cycloalkyl, C6 aryl, 5- to 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Alkoxy, NH2, NMe2, halogen, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, and -C 1~4 It is substituted with one or more of alkylhydroxy.

[0075] In some embodiments of the compound of Formula I, X 2 is H, C3~6 cycloalkyl, C6 aryl, 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2, and halogen (eg, F).

[0076] In some embodiments of the compound of Formula I, X 2 is H, cyclopropyl, cyclobutyl, C6 aryl, pyridinyl, pyrrolidinyl, piperidinyl, morpholinyl, oxetanyl, piperazinyl, azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl, wherein X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NMe2 and halogen, such as F.

[0077] In some embodiments of the compound of Formula I, X 2 is H, cyclopropyl, methyl-cyclopropyl, fluoro-cyclopropyl, difluoro-cyclopropyl, cyclobutyl, C6 aryl, methyl-C6 aryl, fluoro-C6 aryl, methoxy-C6 aryl, pyridinyl, pyrrolidinyl, N-methyl-pyrrolidinyl, methyl-pyrrolidinyl, piperidinyl, N-methylpiperidinyl, methyl-piperidinyl, difluoro-piperidinyl, morpholinyl, N-methyl-morpholinyl, oxetanyl, methyl-oxetanyl, piperazinyl, N-methyl-piperazinyl, azetidinyl, methyl-azetidinyl, N-dimethyl-azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl.

[0078] In some embodiments of the compound of Formula I, L 1 is a straight or branched chain -C 1~4is alkyl, and X 1 -C is a straight or branched chain 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy; or X 1 together with the N atom of the carbamate to form a 5-6 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy.

[0079] In some embodiments of the compound of Formula I, L 1 is a linear or branched chain C 1~4 is alkyl, and X 1 -C is a straight or branched chain 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 alkoxy; or X 1together with the N atom of the carbamate to form a 6-membered heterocycloalkyl, which is unsubstituted or 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0080] In some embodiments of the compound of Formula I, L 1 is a straight or branched chain C 1~4 is alkyl, and X 1 is a straight or branched chain -C 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy; or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, N-methylpiperazinyl, which may be unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C1~4 Alkylhydroxy, or C 1~4 substituted with one or more of alkoxy.

[0081] In some embodiments of the compound of Formula I, L 1 is a straight or branched chain C 1~4 is alkyl, and X 1 -C is a straight or branched chain 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -OCF3, OCHF2, CN, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, piperazinyl, which may be unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0082] In some embodiments of the compound of Formula I, L 1 is -CH2- and X 1 -C is a straight or branched chain 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 5-6 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy.

[0083] In some embodiments of the compound of Formula I, L 1 is -CH2- and X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 6-membered heterocycloalkyl, which is unsubstituted or 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0084] In some embodiments of the compound of Formula I, L 1 is -CH2- and X 1 is a straight or branched chain -C 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, N-methylpiperazinyl, which may be unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, or C 1~4 substituted with one or more of alkoxy.

[0085] In some embodiments of the compound of Formula I, L 1 is -CH2- and X 1 is a straight or branched chain -C 1~6alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -OCF3, OCHF2, CN, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, piperazinyl, which may be unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, and C 1~4 substituted with one or more of alkoxy.

[0086] In some embodiments of the compound of Formula I, L 1 is -CH(CH3)- and X 1 -C is a straight or branched chain 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4alkoxy, or X 1 together with the N atom of the carbamate to form a 5-6 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy.

[0087] In some embodiments of the compound of Formula I, L 1 is -CH(CH3)- and X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 6-membered heterocycloalkyl, which is unsubstituted or 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0088] In some embodiments of the compound of Formula I, L 1 is -CH(CH3)- and X 1 is a straight or branched chain -C 1~6alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, N-methylpiperazinyl, which may be unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, or C 1~4 substituted with one or more of alkoxy.

[0089] In some embodiments of the compound of Formula I, L 1 is -CH(CH3)- and X 1 is a straight or branched chain -C 1~6alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -OCF3, OCHF2, CN, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, piperazinyl, which may be unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0090] In some embodiments of the compound of Formula I, L 1 is -CH(CH3)- and X 1 is phenyl, which is unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl (methyl, etc.), fluorinated C 1~4 alkoxy (such as -OCF3).

[0091] In some embodiments of the compound of Formula I, L 2 is a covalent bond, and X 1 -C is a straight or branched chain 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 5-6 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy.

[0092] In some embodiments of the compound of Formula I, L 2 is a covalent bond, and X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 6-membered heterocycloalkyl, which is unsubstituted or 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0093] In some embodiments of the compound of Formula I, L 2 is a covalent bond, and X 1 -C is a straight or branched chain 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, N-methylpiperazinyl, which may be unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, or C 1~4 substituted with one or more of alkoxy.

[0094] In some embodiments of the compound of Formula I, L 2 is a covalent bond, and X 1 -C is a straight or branched chain 1~6alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -OCF3, OCHF2, CN, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, piperazinyl, which may be unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0095] In some embodiments of the compound of Formula I, L 2 is a straight or branched chain C 1~4 is alkyl, and X 1 -C is a straight or branched chain 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C1~4 alkoxy; or X 1 together with the N atom of the carbamate to form a 5-6 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy.

[0096] In some embodiments of the compound of Formula I, L 2 -C is a straight or branched chain 1~4 is alkyl, and X 1 -C is a straight or branched chain 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 alkoxy; or X 1 together with the N atom of the carbamate to form a 6-membered heterocycloalkyl, which is unsubstituted or 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0097] In some embodiments of the compound of Formula I, L 2 is a straight or branched chain C 1~4 is alkyl, and X 1 is a straight or branched chain -C 1~6alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy; or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, N-methylpiperazinyl, which may be unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, or C 1~4 substituted with one or more of alkoxy.

[0098] In some embodiments of the compound of Formula I, L 2 is a straight or branched chain C 1~4 is alkyl, and X 1 -C is a straight or branched chain 1~6alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -OCF3, OCHF2, CN, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, piperazinyl, which may be unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0099] In some embodiments of the compound of Formula I, L 2 is -CH2- and X 1 -C is a straight or branched chain 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4alkoxy, or X 1 together with the N atom of the carbamate to form a 5-6 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy.

[0100] In some embodiments of the compound of Formula I, L 2 is -CH2- and X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 6-membered heterocycloalkyl, which is unsubstituted or 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0101] In some embodiments of the compound of Formula I, L 2 is -CH2- and X 1 is a straight or branched chain -C 1~6alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, N-methylpiperazinyl, which may be unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, or C 1~4 substituted with one or more of alkoxy.

[0102] In some embodiments of the compound of Formula I, L 2 is -CH2- and X 1 is a straight or branched chain -C 1~6alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -OCF3, OCHF2, CN, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, piperazinyl, which may be unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0103] In some embodiments of the compound of Formula I, L 2 is -CH2- and X 1 is phenyl, which is unsubstituted or is selected from the group consisting of halogen, straight-chain or branched -C 1~4 Alkyl, and C 1~4 and is substituted with one or more of -alkoxy, and is preferably unsubstituted or substituted with -OMe.

[0104] In some embodiments of the compound of Formula I, L 2 is -CH(CH3)- and X 1 -C is a straight or branched chain 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 5-6 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy.

[0105] In some embodiments of the compound of Formula I, L 2 is -CH(CH3)- and X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 6-membered heterocycloalkyl, which is unsubstituted or 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0106] In some embodiments of the compound of Formula I, L 2 is -CH(CH3)- and X 1 is a straight or branched chain -C 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, piperidinyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, N-methylpiperazinyl, which may be unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, or C 1~4 substituted with one or more of alkoxy.

[0107] In some embodiments of the compound of Formula I, L 2 is -CH(CH3)- and X 1 is a straight or branched chain -C 1~6alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -OCF3, OCHF2, CN, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, piperazinyl, which may be unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0108] In some embodiments of the compound of Formula II, n is 1 and R a is H and L 2 is -CH(CH3)- and X 1 is phenyl.

[0109] In some embodiments of the compound of Formula I, L 1 is -CH2-, and L 2 is a covalent bond, and X 1 -C is a straight or branched chain 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, wherein X 1is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 5-6 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy.

[0110] In some embodiments of the compound of Formula I, L 1 is -CH2-, and L 2 is a covalent bond, and X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 6-membered heterocycloalkyl, which is unsubstituted or 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0111] In some embodiments of the compound of Formula I, L 1 is -CH2-, and L 2 is a covalent bond, and X 1 -C is a straight or branched chain 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, N-methylpiperazinyl, which may be unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, or C 1~4 substituted with one or more of alkoxy.

[0112] In some embodiments of the compound of Formula I, L 1 is -CH2-, and L 2 is a covalent bond, and X 1 -C is a straight or branched chain1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -OCF3, OCHF2, CN, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, piperazinyl, which may be unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, and C 1~4 substituted with one or more of alkoxy.

[0113] In some embodiments of the compound of Formula I, L 1 is -CH2-, and L 2 is a straight or branched chain C 1~4 is alkyl, and X 1 -C is a straight or branched chain 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C1~4 Alkylhydroxy, and C 1~4 alkoxy; or X 1 together with the N atom of the carbamate to form a 5-6 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy.

[0114] In some embodiments of the compound of Formula I, L 1 is -CH2-, and L 2 is a straight or branched chain C 1~4 is alkyl, and X 1 -C is a straight or branched chain 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 alkoxy; or X 1 together with the N atom of the carbamate to form a 6-membered heterocycloalkyl, which is unsubstituted or 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0115] In some embodiments of the compound of Formula I, L 1 is -CH2-, and L 2 is a straight or branched chain C 1~4 is alkyl, and X 1is a straight or branched chain -C 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy; or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, N-methylpiperazinyl, which may be unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, or C 1~4 substituted with one or more of alkoxy.

[0116] In some embodiments of the compound of Formula I, L 1 is -CH2-, and L 2 is a straight or branched chain C 1~4 is alkyl, and X 1 -C is a straight or branched chain 1~6alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -OCF3, OCHF2, CN, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, piperazinyl, which may be unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0117] In some embodiments of the compound of Formula I, L 1 is -CH2-, and L 2 is -CH2- and X 1 -C is a straight or branched chain 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 5-6 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy.

[0118] In some embodiments of the compound of Formula I, L 1 is -CH2-, and L 2 is -CH2- and X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 6-membered heterocycloalkyl, which is unsubstituted or 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0119] In some embodiments of the compound of Formula I, L 1 is -CH2-, and L 2 is -CH2- and X 1 is a straight or branched chain -C 1~6alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, N-methylpiperazinyl, which may be unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, or C 1~4 substituted with one or more of alkoxy.

[0120] In some embodiments of the compound of Formula I, L 1 is -CH2-, and L 2 is -CH2- and X 1 is a straight or branched chain -C 1~6alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -OCF3, OCHF2, CN, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, piperazinyl, which may be unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0121] In some embodiments of the compound of Formula I, L 1 is -CH2-, and L 2 is -CH2- and X 1 is phenyl, which is unsubstituted or is selected from the group consisting of halogen, straight-chain or branched -C 1~4 Alkyl, and C 1~4 and is substituted with one or more of -alkoxy, and is preferably unsubstituted or substituted with -OMe.

[0122] In some embodiments of the compound of Formula I, L 1 is -CH2-, and L 2 is -CH(CH3)- and X 1 -C is a straight or branched chain1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 5-6 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy.

[0123] In some embodiments of the compound of Formula I, L 1 is -CH2-, and L 2 is -CH(CH3)- and X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 6-membered heterocycloalkyl, which is unsubstituted or 1~4Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0124] In some embodiments of the compound of Formula I, L 1 is -CH2-, and L 2 is -CH(CH3)- and X 1 is a straight or branched chain -C 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, N-methylpiperazinyl, which may be unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, or C 1~4 substituted with one or more of alkoxy.

[0125] In some embodiments of the compound of Formula I, L 1 is -CH2-, and L 2 is -CH(CH3)- and X 1 is a straight or branched chain -C 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -OCF3, OCHF2, CN, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, piperazinyl, which may be unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0126] In some embodiments of the compound of Formula I, L 1 is -CH2-, and L 2 is -CH(CH3)- and X 1 is phenyl.

[0127] In some embodiments of the compound of Formula I, L 1 is -CH(CH3)-, and L 2 is a covalent bond, and X 1-C is a straight or branched chain 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 5-6 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy.

[0128] In some embodiments of the compound of Formula I, L 1 is -CH(CH3)-, and L 2 is a covalent bond, and X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 6-membered heterocycloalkyl, which is unsubstituted or1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0129] In some embodiments of the compound of Formula I, L 1 is -CH(CH3)-, and L 2 is a covalent bond, and X 1 -C is a straight or branched chain 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, N-methylpiperazinyl, which may be unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, or C 1~4 substituted with one or more of alkoxy.

[0130] In some embodiments of the compound of Formula I, L 1 is -CH(CH3)-, and L 2 is a covalent bond, and X 1 -C is a straight or branched chain 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -OCF3, OCHF2, CN, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, piperazinyl, which may be unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0131] In some embodiments of the compound of Formula I, L 1 is -CH(CH3)-, and L 2 is a covalent bond, and X 1 is phenyl, which is unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl (methyl, etc.), fluorinated C 1~4 alkoxy (such as -OCF3).

[0132] In some embodiments of the compound of Formula I, L 1 is -CH(CH3)-, and L 2 -C is a straight or branched chain 1~4 is alkyl, and X 1 -C is a straight or branched chain 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy; or X 1 together with the N atom of the carbamate to form a 5-6 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy.

[0133] In some embodiments of the compound of Formula I, L 1 is -CH(CH3)-, and L 2 is a straight or branched chain C 1~4 is alkyl, and X 1 -C is a straight or branched chain 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN and C 1~4 alkoxy; or X 1 together with the N atom of the carbamate to form a 6-membered heterocycloalkyl, which is unsubstituted or 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0134] In some embodiments of the compound of Formula I, L 1 is -CH(CH3)-, and L 2 is a straight or branched chain C 1~4 is alkyl, and X 1 is a straight or branched chain -C 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy; or X 1together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, N-methylpiperazinyl, which may be unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, or C 1~4 substituted with one or more of alkoxy.

[0135] In some embodiments of the compound of Formula I, L 1 is -CH(CH3)-, and L 2 is a straight or branched chain C 1~4 is alkyl, and X 1 -C is a straight or branched chain 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -OCF3, OCHF2, CN, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, piperazinyl, which may be unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C1~4 substituted with one or more of alkoxy.

[0136] In some embodiments of the compound of Formula I, L 1 is -CH(CH3)-, and L 2 is -CH2- and X 1 -C is a straight or branched chain 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 5-6 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy.

[0137] In some embodiments of the compound of Formula I, L 1 is -CH(CH3)-, and L 2 is -CH2- and X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 6-membered heterocycloalkyl, which is unsubstituted or 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0138] In some embodiments of the compound of Formula I, L 1 is -CH(CH3)-, and L 2 is -CH2- and X 1 is a straight or branched chain -C 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy or X 1together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, N-methylpiperazinyl, which may be unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, or C 1~4 substituted with one or more of alkoxy.

[0139] In some embodiments of the compound of Formula I, L 1 is -CH(CH3)-, and L 2 is -CH2- and X 1 is a straight or branched chain -C 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -OCF3, OCHF2, CN, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, piperazinyl, which may be unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4substituted with one or more of alkoxy.

[0140] In some embodiments of the compound of Formula I, L 1 is -CH(CH3)-, and L 2 is -CH(CH3)- and X 1 -C is a straight or branched chain 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 5-6 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy.

[0141] In some embodiments of the compound of Formula I, L 1 is -CH(CH3)-, and L 2 is -CH(CH3)- and X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 6-membered heterocycloalkyl, which is unsubstituted or 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0142] In some embodiments of the compound of Formula I, L 1 is -CH(CH3)-, and L 2 is -CH(CH3)- and X 1 is a straight or branched chain -C 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy or X 1together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, N-methylpiperazinyl, which may be unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, or C 1~4 substituted with one or more of alkoxy.

[0143] In some embodiments of the compound of Formula I, L 1 is -CH(CH3)-, and L 2 is -CH(CH3)- and X 1 is a straight or branched chain -C 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -OCF3, OCHF2, CN, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, piperazinyl, which may be unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4substituted with one or more of alkoxy.

[0144] In some embodiments of the compound of Formula I, L 2 is a covalent bond, and X 2 is H, C 3~6 cycloalkyl, C6 aryl, 5- to 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~6 Alkyl, -C 1~4 Alkoxy, NH2, NMe2, halogen, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, and -C 1~4 It is substituted with one or more of alkylhydroxy.

[0145] In some embodiments of the compound of Formula I, L 2 is a covalent bond, and X 2 is H, C 3~6 cycloalkyl, C6 aryl, 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2, and halogen (eg, F).

[0146] In some embodiments of the compound of Formula I, L 2 is a covalent bond, and X 2 is H, cyclopropyl, cyclobutyl, C6 aryl, pyridinyl, pyrrolidinyl, piperidinyl, morpholinyl, oxetanyl, piperazinyl, azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl, wherein X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2 and halogen.

[0147] In some embodiments of the compound of Formula I, L 2 is a covalent bond, and X 2 is H, cyclopropyl, methyl-cyclopropyl, fluoro-cyclopropyl, difluoro-cyclopropyl, cyclobutyl, C6 aryl, methyl-C6 aryl, fluoro-C6 aryl, methoxy-C6 aryl, pyridinyl, pyrrolidinyl, N-methyl-pyrrolidinyl, methyl-pyrrolidinyl, piperidinyl, N-methylpiperidinyl, methyl-piperidinyl, difluoro-piperidinyl, morpholinyl, N-methyl-morpholinyl, oxetanyl, methyl-oxetanyl, piperazinyl, N-methyl-piperazinyl, azetidinyl, methyl-azetidinyl, N-dimethyl-azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl.

[0148] In some embodiments of the compound of Formula I, L 2 is -CH2- and X 2 is H, C 3~6 cycloalkyl, C6 aryl, 5- to 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~6 Alkyl, -C 1~4 Alkoxy, NH2, NMe2, halogen, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, and -C 1~4 It is substituted with one or more of alkylhydroxy.

[0149] In some embodiments of the compound of Formula I, L 2 is -CH2- and X 2 is H, C 3~6 cycloalkyl, C6 aryl, 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4Substituted with one or more of alkoxy, NH2, NMe2, halogen (eg, F).

[0150] In some embodiments of the compound of Formula I, L 2 is -CH2- and X 2 is a C6 aryl, which is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 and substituted with one or more of alkoxy, for example, unsubstituted or substituted with -OMe.

[0151] In some embodiments of the compound of Formula I, L 2 is -CH(CH3)- and X 2 is H, C 3~6 cycloalkyl, C6 aryl, 5- to 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~6 Alkyl, -C 1~4 Alkoxy, NH2, NMe2, halogen, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, and -C 1~4 It is substituted with one or more of alkylhydroxy.

[0152] In some embodiments of the compound of Formula I, L 2 is -CH(CH3)- and X 2 is H, C 3~6 cycloalkyl, C6 aryl, 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2, halogen (eg, F).

[0153] In some embodiments of the compound of Formula I, L 2 is -CH(CH3)- and X 2is a C6 aryl, which is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 It may be substituted with one or more of alkoxy, for example, unsubstituted.

[0154] In some embodiments of the compound of Formula I, L 3 is a covalent bond, and X 2 is H, C 3~6 cycloalkyl, C6 aryl, 5- to 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~6 Alkyl, -C 1~4 Alkoxy, NH2, NMe2, halogen, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, and -C 1~4 It is substituted with one or more of alkylhydroxy.

[0155] In some embodiments of the compound of Formula I, L 3 is a covalent bond, and X 2 is H, C 3~6 cycloalkyl, C6 aryl, 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2, and halogen (eg, F).

[0156] In some embodiments of the compound of Formula I, L 3 is a covalent bond, and X 2 is H, cyclopropyl, cyclobutyl, C6 aryl, pyridinyl, pyrrolidinyl, piperidinyl, morpholinyl, oxetanyl, piperazinyl, azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl, wherein X 2 is unsubstituted or a straight or branched chain C 1~4Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2 and halogen.

[0157] In some embodiments of the compound of Formula I, L 3 is a covalent bond, and X 2 is cyclopropyl, cyclobutyl, azetidinyl, oxetanyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl, C6 aryl, pyridinyl, wherein X 2 is unsubstituted or a straight or branched chain C 1~6 Alkyl, e.g., methyl, -C 1~4 Substituted with one or more of alkoxy, eg, -OMe, NMe2, and halogen, eg, F.

[0158] In some embodiments of the compound of Formula I, L 3 is a covalent bond, and X 2 is H, cyclopropyl, methyl-cyclopropyl, fluoro-cyclopropyl, difluoro-cyclopropyl, cyclobutyl, C6 aryl, methyl-C6 aryl, fluoro-C6 aryl, methoxy-C6 aryl, pyridinyl, pyrrolidinyl, N-methyl-pyrrolidinyl, methyl-pyrrolidinyl, piperidinyl, N-methylpiperidinyl, methyl-piperidinyl, difluoro-piperidinyl, morpholinyl, N-methyl-morpholinyl, oxetanyl, methyl-oxetanyl, piperazinyl, N-methyl-piperazinyl, azetidinyl, methyl-azetidinyl, N-dimethyl-azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl.

[0159] In some embodiments of the compound of Formula I, L 3 is a covalent bond, and X 2is cyclopropyl, methyl-cyclopropyl, fluoro-cyclopropyl, difluoro-cyclopropyl, cyclobutyl, azetidinyl, NMe2-azetidinyl, oxetanyl, methyl-oxetanyl, pyrrolidinyl, methyl-pyrrolidinyl, piperidinyl, Me-piperidinyl, di-F-piperidinyl, N-Me-piperazinyl, morpholinyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl, C6 aryl, methoxy-C6 aryl, pyridinyl.

[0160] In some embodiments of the compound of Formula I, L 3 is a linear or branched chain C 1~4 is alkyl (such as -CH2-), and X 2 is H, C 3~6 cycloalkyl, C6 aryl, 5- to 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~6 Alkyl, -C 1~4 Alkoxy, NH2, NMe2, halogen, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, and -C 1~4 It is substituted with one or more of alkylhydroxy.

[0161] In some embodiments of the compound of Formula I, L 3 is a linear or branched chain C 1~4 is alkyl (such as -CH2-), and X 2 is H, C 3~6 cycloalkyl, C6 aryl, 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2, halogen (eg, F).

[0162] In some embodiments of the compound of Formula I, L 3 is a linear or branched chain C 1~4is alkyl (such as -CH2-), and X 2 is H, cyclopropyl, cyclobutyl, C6 aryl, pyridinyl, pyrrolidinyl, piperidinyl, morpholinyl, oxetanyl, piperazinyl, azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl, wherein X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2 and halogen.

[0163] In some embodiments of the compound of Formula I, L 3 is a straight or branched chain C 1~4 is alkyl (such as -CH2-), and X 2 is H, cyclopropyl, methyl-cyclopropyl, fluoro-cyclopropyl, difluoro-cyclopropyl, cyclobutyl, C6 aryl, methyl-C6 aryl, fluoro-C6 aryl, methoxy-C6 aryl, pyridinyl, pyrrolidinyl, N-methyl-pyrrolidinyl, methyl-pyrrolidinyl, piperidinyl, N-methylpiperidinyl, methyl-piperidinyl, difluoro-piperidinyl, morpholinyl, N-methyl-morpholinyl, oxetanyl, methyl-oxetanyl, piperazinyl, N-methyl-piperazinyl, azetidinyl, methyl-azetidinyl, N-dimethyl-azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl.

[0164] In some embodiments of the compound of Formula I, L 3 is a linear or branched chain C 1~4 is alkyl (such as -CH2-), and X 2 is morpholinyl, N-methyl-morpholinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl.

[0165] In some embodiments of the compound of Formula I, L 3 is -O- and X 2 is H, C 3~6 cycloalkyl, C6 aryl, 5- to 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~6 Alkyl, -C 1~4 Alkoxy, NH2, NMe2, halogen, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, and -C 1~4 It is substituted with one or more of alkylhydroxy.

[0166] In some embodiments of the compound of Formula I, L 3 is -O- and X 2 is H, C 3~6 cycloalkyl, C6 aryl, 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2, halogen (eg, F).

[0167] In some embodiments of the compound of Formula I, L 3 is -O- and X 2 is H, cyclopropyl, cyclobutyl, C6 aryl, pyridinyl, pyrrolidinyl, piperidinyl, morpholinyl, oxetanyl, piperazinyl, azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl, wherein X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2 and halogen.

[0168] In some embodiments of the compound of Formula I, L 3 is -O- and X 2is H, cyclopropyl, methyl-cyclopropyl, fluoro-cyclopropyl, difluoro-cyclopropyl, cyclobutyl, C6 aryl, methyl-C6 aryl, fluoro-C6 aryl, methoxy-C6 aryl, pyridinyl, pyrrolidinyl, N-methyl-pyrrolidinyl, methyl-pyrrolidinyl, piperidinyl, N-methylpiperidinyl, methyl-piperidinyl, difluoro-piperidinyl, morpholinyl, N-methyl-morpholinyl, oxetanyl, methyl-oxetanyl, piperazinyl, N-methyl-piperazinyl, azetidinyl, methyl-azetidinyl, N-dimethyl-azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl.

[0169] In some embodiments of the compound of Formula I, L 3 is -O- and X 2 is cyclopropyl, pyrrolidinyl, N-methyl-pyrrolidinyl.

[0170] In some embodiments of the compound of Formula I, L 3 is -O-CH2-, and X 2 is H, C 3~6 cycloalkyl, C6 aryl, 5- to 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~6 Alkyl, -C 1~4 Alkoxy, NH2, NMe2, halogen, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, and -C 1~4 It is substituted with one or more of alkylhydroxy.

[0171] In some embodiments of the compound of Formula I, L 3 is -O-CH2-, and X 2 is H, C 3~6 cycloalkyl, C6 aryl, 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~4Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2, and halogen (eg, F).

[0172] In some embodiments of the compound of Formula I, L 3 is -O-CH2-, and X 2 is H, cyclopropyl, cyclobutyl, C6 aryl, pyridinyl, pyrrolidinyl, piperidinyl, morpholinyl, oxetanyl, piperazinyl, azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl, wherein X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2 and halogen.

[0173] In some embodiments of the compound of Formula I, L 3 is -O-CH2-, and X 2 is H, cyclopropyl, methyl-cyclopropyl, fluoro-cyclopropyl, difluoro-cyclopropyl, cyclobutyl, C6 aryl, methyl-C6 aryl, fluoro-C6 aryl, methoxy-C6 aryl, pyridinyl, pyrrolidinyl, N-methyl-pyrrolidinyl, methyl-pyrrolidinyl, piperidinyl, N-methylpiperidinyl, methyl-piperidinyl, difluoro-piperidinyl, morpholinyl, N-methyl-morpholinyl, oxetanyl, methyl-oxetanyl, piperazinyl, N-methyl-piperazinyl, azetidinyl, methyl-azetidinyl, N-dimethyl-azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl.

[0174] In some embodiments of the compound of Formula I, L 3 is -O-CH2-, and X 2 is pyrrolidinyl, N-methyl-pyrrolidinyl.

[0175] In some embodiments of the compound of Formula I, L 3 is -O-CH2-CH2- and X 2 is H, C 3~6 cycloalkyl, C6 aryl, 5- to 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~6 Alkyl, -C 1~4 Alkoxy, NH2, NMe2, halogen, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, and -C 1~4 It is substituted with one or more of alkylhydroxy.

[0176] In some embodiments of the compound of Formula I, L 3 is -O-CH2-CH2- and X 2 is H, C 3~6 cycloalkyl, C6 aryl, 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2, and halogen (eg, F).

[0177] In some embodiments of the compound of Formula I, L 3 is -O-CH2-CH2- and X 2 is H, cyclopropyl, cyclobutyl, C6 aryl, pyridinyl, pyrrolidinyl, piperidinyl, morpholinyl, oxetanyl, piperazinyl, azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl, wherein X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2 and halogen.

[0178] In some embodiments of the compound of Formula I, L 3 is -O-CH2-CH2- and X 2 is H, cyclopropyl, methyl-cyclopropyl, fluoro-cyclopropyl, difluoro-cyclopropyl, cyclobutyl, C6 aryl, methyl-C6 aryl, fluoro-C6 aryl, methoxy-C6 aryl, pyridinyl, pyrrolidinyl, N-methyl-pyrrolidinyl, methyl-pyrrolidinyl, piperidinyl, N-methylpiperidinyl, methyl-piperidinyl, difluoro-piperidinyl, morpholinyl, N-methyl-morpholinyl, oxetanyl, methyl-oxetanyl, piperazinyl, N-methyl-piperazinyl, azetidinyl, methyl-azetidinyl, N-dimethyl-azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl.

[0179] In some embodiments of the compound of Formula I, L 3 is -O-CH2-CH2- and X 2 is morpholinyl.

[0180] In certain embodiments, the compound of formula I is a compound of formula II or a pharmaceutically acceptable salt or stereoisomer thereof: [ka] During the ceremony, X 1 is a linear or branched chain C 1~6 Alkyl, C 3~6 Cycloalkyl, C 6~10 aryl, 5- to 10-membered heteroaryl, 4- to 8-membered heterocycloalkyl; X 1 is unsubstituted or substituted with halogen, linear or branched C 1~6 Alkyl, straight or branched chain C 1~6 Heteroalkyl, CF3, CHF2, CMeF2, -O-CHF2, -O-(CH2)2-OMe, OCF3, C 1~6 Alkylamino, -CN, -N(H)C(O)-C 1~6 Alkyl, -OC(O)-C1~6 Alkyl, -OC(O)-C 1~4 Alkylamino, -C(O)OC 1~6 Alkyl, -COOH, -C 1~6 AlkylC(O)OH, -C 1~6 Alkyl C(O)OC 1~6 Alkyl, NH2, C 1~4 Alkoxy, and C 1~4 substituted with one or more of alkylhydroxy; or X 1 together with the N atom of the carbamate to form a 4- to 8-membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight- or branched-chain -C 1~6 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, -N(H)C(O)-C 1~6 Alkyl, -OC(O)-C 1~6 Alkyl, -C(O)OC 1~6 Alkyl, -COOH, -C 1~6 AlkylC(O)OH, -C 1~6 Alkyl C(O)OC 1~6 Alkyl, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy; X 2 is H, C 3~6 Cycloalkyl, C 6~10 aryl, 5- to 10-membered heteroaryl, or 4- to 8-membered heterocycloalkyl; and X 2 is unsubstituted or a straight or branched chain C 1~6 Alkyl, -C 1~4 Alkoxy, NH2, NMe2, halogen, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, and C 1~4 substituted with one or more of alkylhydroxy; L 2 is a covalent bond, linear or branched C 1~6 is alkyl, and L 3 is a covalent bond, linear or branched C1~6 Alkyl, -O-, -C 1~4 is an alkoxy, R a is H or straight or branched chain C 1~4 alkyl (such as methyl or ethyl) and n is 1 or 2.

[0181] In some embodiments of the compound of Formula II, R a is H. In some embodiments of the compound of Formula II, R a is a straight or branched chain C such as methyl 1~4 It is alkyl.

[0182] In some embodiments of the compound of Formula II, n is 1.

[0183] In some embodiments of the compound of Formula II, L 2 is a covalent bond. In some embodiments of the compound of Formula II, L 2 is a straight or branched chain C 1~6 In some embodiments of the compound of Formula II, L is alkyl. 2 is a straight or branched chain C such as -CH2- or -CH(CH3)- 1~4 It is alkyl.

[0184] In some embodiments of the compound of Formula II, L 3 is a covalent bond. In some embodiments of the compound of Formula II, L 3 is a linear or branched chain C 1~4 In some embodiments of the compound of Formula II, L is alkyl. 3 is —O—. In some embodiments, L 3 is a straight or branched chain C such as -O-CH2-, -O-CH2-CH2-, O-CH2-CH2-CH2- 1~4 It is an alkoxy.

[0185] In some embodiments of the compound of Formula II, L 1 is -CH2-, and L 2is a covalent bond. In some embodiments of the compound of Formula II, L 1 is -CH2-, and L 2 is -CH-. In some embodiments, L 1 is -CH2-, and L 2 is -CH(CH3)-.

[0186] In some embodiments of the compound of Formula II, L 1 is -CH2-, and L 2 is a covalent bond, and L 3 is a covalent bond. In some embodiments of the compound of Formula II, L 1 is -CH2-, and L 2 is a covalent bond, and L 3 In some embodiments of the compound of Formula II, L 1 is -CH2-, and L 2 is a covalent bond, and L 3 In some embodiments of the compound of Formula II, L 1 is -CH2-, and L 2 is a covalent bond, and L 3 is —O—CH—. In some embodiments of the compound of Formula II, L 1 is -CH2-, and L 2 is a covalent bond, and L 3 is -O-CH2-CH2-.

[0187] In some embodiments of the compound of Formula II, X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4alkoxy; or X 1 together with the N atom of the carbamate to form a 5-6 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy.

[0188] In some embodiments of the compound of Formula II, X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 6-membered heterocycloalkyl, which is unsubstituted or 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0189] In some embodiments of the compound of Formula II, X 1 is a straight or branched chain -C 1~6alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, N-methylpiperazinyl, which may be unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, or C 1~4 substituted with one or more of alkoxy.

[0190] In some embodiments of the compound of Formula II, X 1 is a straight or branched chain -C 1~6alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -OCF3, OCHF2, CN, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, piperazinyl, which may be unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0191] In some embodiments of the compound of Formula II, X 2 is H, C 3~6 cycloalkyl, C6 aryl, 5- to 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~6 Alkyl, -C 1~4 Alkoxy, NH2, NMe2, halogen, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, and -C 1~4 It is substituted with one or more of alkylhydroxy.

[0192] In some embodiments of the compound of Formula II, X 2 is H, C3~6 cycloalkyl, C6 aryl, 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2, and halogen (eg, F).

[0193] In some embodiments of the compound of Formula II, X 2 is H, cyclopropyl, cyclobutyl, C6 aryl, pyridinyl, pyrrolidinyl, piperidinyl, morpholinyl, oxetanyl, oxetanyl, piperazinyl, azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl, wherein X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2 and halogen.

[0194] In some embodiments of the compound of Formula II, X 2 is H, cyclopropyl, methyl-cyclopropyl, fluoro-cyclopropyl, difluoro-cyclopropyl, cyclobutyl, C6 aryl, methyl-C6 aryl, fluoro-C6 aryl, methoxy-C6 aryl, pyridinyl, pyrrolidinyl, N-methyl-pyrrolidinyl, methyl-pyrrolidinyl, piperidinyl, N-methylpiperidinyl, methyl-piperidinyl, difluoro-piperidinyl, morpholinyl, N-methyl-morpholinyl, oxetanyl, methyl-oxetanyl, piperazinyl, N-methyl-piperazinyl, azetidinyl, methyl-azetidinyl, N-dimethyl-azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl.

[0195] In some embodiments of the compound of Formula II, n is 1 and R a is H and X1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy; or X 1 together with the N atom of the carbamate to form a 5-6 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy.

[0196] In some embodiments of the compound of Formula II, n is 1 and R a is H and X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 6-membered heterocycloalkyl, which is unsubstituted or 1~4Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0197] In some embodiments of the compound of Formula II, n is 1 and R a is H and X 1 is a straight or branched chain -C 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, N-methylpiperazinyl, which may be unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, or C 1~4 substituted with one or more of alkoxy.

[0198] In some embodiments of the compound of Formula II, n is 1 and R a is H and X 1 is a straight or branched chain -C 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -OCF3, OCHF2, CN, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, piperazinyl, which may be unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0199] In some embodiments of the compound of Formula II, n is 1 and R a is -CH3 and X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy; or X 1 together with the N atom of the carbamate to form a 5-6 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy.

[0200] In some embodiments of the compound of Formula II, n is 1 and R a is -CH3 and X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 6-membered heterocycloalkyl, which is unsubstituted or 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0201] In some embodiments of the compound of Formula II, n is 1 and R a is -CH3 and X 1is a straight or branched chain -C 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, N-methylpiperazinyl, which may be unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, or C 1~4 substituted with one or more of alkoxy.

[0202] In some embodiments of the compound of Formula II, n is 1 and R a is -CH3 and X 1 is a straight or branched chain -C 1~6alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -OCF3, OCHF2, CN, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, piperazinyl, which may be unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0203] In some embodiments of the compound of Formula II, n is 1 and R a is -CH3- and X 1 is phenyl, which is unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl (methyl, etc.), fluorinated C 1~4 alkoxy (such as -OCF3).

[0204] In some embodiments of the compound of Formula II, L 2 is a covalent bond, and X 1 -C is a straight or branched chain 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 5-6 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy.

[0205] In some embodiments of the compound of Formula II, L 2 is a covalent bond, and X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 6-membered heterocycloalkyl, which is unsubstituted or 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0206] In some embodiments of the compound of Formula II, L 2 is a covalent bond, and X 1 -C is a straight or branched chain 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, N-methylpiperazinyl, which may be unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, or C 1~4 substituted with one or more of alkoxy.

[0207] In some embodiments of the compound of Formula II, L 2 is a covalent bond, and X 1 -C is a straight or branched chain 1~6alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -OCF3, OCHF2, CN, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, piperazinyl, which may be unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0208] In some embodiments of the compound of Formula II, L 2 -C is a straight or branched chain 1~4 is alkyl, and X 1 -C is a straight or branched chain 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C1~4 alkoxy; or X 1 together with the N atom of the carbamate to form a 5-6 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy.

[0209] In some embodiments of the compound of Formula II, L 2 -C is a straight or branched chain 1~4 is alkyl, and X 1 -C is a straight or branched chain 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN and C 1~4 alkoxy; or X 1 together with the N atom of the carbamate to form a 6-membered heterocycloalkyl, which is unsubstituted or 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0210] In some embodiments of the compound of Formula II, L 2 is a straight or branched chain C 1~4 is alkyl, and X 1 is a straight or branched chain -C 1~6alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy; or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, N-methylpiperazinyl, which may be unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, or C 1~4 substituted with one or more of alkoxy.

[0211] In some embodiments of the compound of Formula II, L 2 is a straight or branched chain C 1~4 is alkyl, and X 1 -C is a straight or branched chain 1~6alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -OCF3, OCHF2, CN, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, piperazinyl, which may be unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0212] In some embodiments of the compound of Formula II, L 2 is -CH2- and X 1 -C is a straight or branched chain 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4alkoxy, or X 1 together with the N atom of the carbamate to form a 5-6 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy.

[0213] In some embodiments of the compound of Formula II, L 2 is -CH2- and X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 6-membered heterocycloalkyl, which is unsubstituted or 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0214] In some embodiments of the compound of Formula II, L 2 is -CH2- and X 1 is a straight or branched chain -C 1~6alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, N-methylpiperazinyl, which may be unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, or C 1~4 substituted with one or more of alkoxy.

[0215] In some embodiments of the compound of Formula II, L 2 is -CH2- and X 1 is a straight or branched chain -C 1~6alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -OCF3, OCHF2, CN, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, piperazinyl, which may be unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0216] In some embodiments of the compound of Formula II, L 2 is -CH2- and X 1 is phenyl, which is unsubstituted or is selected from the group consisting of halogen, straight-chain or branched -C 1~4 Alkyl, and C 1~4 It is substituted with one or more of alkoxy, preferably -OMe.

[0217] In some embodiments of the compound of Formula II, L 2 is -CH(CH3)- and X 1 -C is a straight or branched chain 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 5-6 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy.

[0218] In some embodiments of the compound of Formula II, L 2 is -CH(CH3)- and X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 6-membered heterocycloalkyl, which is unsubstituted or 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0219] In some embodiments of the compound of Formula II, L 2 is -CH(CH3)- and X 1 is a straight or branched chain -C 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, N-methylpiperazinyl, which may be unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, or C 1~4 substituted with one or more of alkoxy.

[0220] In some embodiments of the compound of Formula II, L 2 is -CH(CH3)- and X 1is a straight or branched chain -C 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -OCF3, OCHF2, CN, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, piperazinyl, which may be unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0221] In some embodiments of the compound of Formula II, L 2 is -CH(CH3)- and X 1 is phenyl.

[0222] In some embodiments of the compound of Formula II, n is 1 and R a is H and L 2 is a covalent bond, and X 1 -C is a straight or branched chain 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, wherein X 1is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 5-6 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy.

[0223] In some embodiments of the compound of Formula II, n is 1 and R a is H and L 2 is a covalent bond, and X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 6-membered heterocycloalkyl, which is unsubstituted or 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0224] In some embodiments of the compound of Formula II, n is 1 and R a is H and L 2 is a covalent bond, and X 1 -C is a straight or branched chain 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, N-methylpiperazinyl, which may be unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, or C 1~4 substituted with one or more of alkoxy.

[0225] In some embodiments of the compound of Formula II, n is 1 and R a is H and L 2 is a covalent bond, and X 1-C is a straight or branched chain 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -OCF3, OCHF2, CN, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, piperazinyl, which may be unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0226] In some embodiments of the compound of Formula II, n is 1 and R a is H and L 2 is a straight or branched chain C 1~4 is alkyl, and X 1 -C is a straight or branched chain 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy; or X 1 together with the N atom of the carbamate to form a 5-6 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy.

[0227] In some embodiments of the compound of Formula II, n is 1 and R a is H and L 2 is a straight or branched chain C 1~4 is alkyl, and X 1 -C is a straight or branched chain 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 6-membered heterocycloalkyl, which is unsubstituted or 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0228] In some embodiments of the compound of Formula II, n is 1 and R a is H and L 2 is a straight or branched chain C 1~4is alkyl, and X 1 is a straight or branched chain -C 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy; or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, N-methylpiperazinyl, which may be unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, or C 1~4 substituted with one or more of alkoxy.

[0229] In some embodiments of the compound of Formula II, n is 1 and R a is H and L 2 is a straight or branched chain C 1~4 is alkyl, and X 1 -C is a straight or branched chain 1~6alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -OCF3, OCHF2, CN, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, piperazinyl, which may be unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0230] In some embodiments of the compound of Formula II, n is 1 and R a is H and L 2 is -CH2- and X 1 -C is a straight or branched chain 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 5-6 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy.

[0231] In some embodiments of the compound of Formula II, n is 1 and R a is H and L 2 is -CH2- and X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 6-membered heterocycloalkyl, which is unsubstituted or 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0232] In some embodiments of the compound of Formula II, n is 1 and R a is H and L 2 is -CH2- and X 1 is a straight or branched chain -C 1~6alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, N-methylpiperazinyl, which may be unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, or C 1~4 substituted with one or more of alkoxy.

[0233] In some embodiments of the compound of Formula II, n is 1 and R a is H and L 2 is -CH2- and X 1 is a straight or branched chain -C 1~6alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -OCF3, OCHF2, CN, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, piperazinyl, which may be unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0234] In some embodiments of the compound of Formula II, n is 1 and R a is H and L 2 is -CH2- and X 1 is phenyl, which is unsubstituted or is selected from the group consisting of halogen, straight-chain or branched -C 1~4 Alkyl, and C 1~4 and is substituted with one or more of -alkoxy, and is preferably unsubstituted or substituted with -OMe.

[0235] In some embodiments of the compound of Formula II, n is 1 and R a is H and L 2 is -CH(CH3)- and X 1 -C is a straight or branched chain1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 5-6 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy.

[0236] In some embodiments of the compound of Formula II, n is 1 and R a is H and L 2 is -CH(CH3)- and X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 6-membered heterocycloalkyl, which is unsubstituted or 1~4Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0237] In some embodiments of the compound of Formula II, n is 1 and R a is H and L 2 is -CH(CH3)- and X 1 is a straight or branched chain -C 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, N-methylpiperazinyl, which may be unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, or C 1~4 substituted with one or more of alkoxy.

[0238] In some embodiments of the compound of Formula II, n is 1 and R a is H and L 2 is -CH(CH3)- and X 1 is a straight or branched chain -C 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -OCF3, OCHF2, CN, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, piperazinyl, which may be unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0239] In some embodiments of the compound of Formula II, n is 1 and R a is H and L 2 is -CH(CH3)- and X 1 is phenyl.

[0240] In some embodiments of the compound of Formula II, n is 1 and R a is -CH3, and L 2is a covalent bond, and X 1 -C is a straight or branched chain 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 5-6 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy.

[0241] In some embodiments of the compound of Formula II, n is 1 and R a is -CH3, and L 2 is a covalent bond, and X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 alkoxy, or X 1together with the N atom of the carbamate to form a 6-membered heterocycloalkyl, which is unsubstituted or 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0242] In some embodiments of the compound of Formula II, n is 1 and R a is -CH3, and L 2 is a covalent bond, and X 1 -C is a straight or branched chain 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, N-methylpiperazinyl, which may be unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, or C 1~4 substituted with one or more of alkoxy.

[0243] In some embodiments of the compound of Formula II, n is 1 and R a is -CH3, and L 2 is a covalent bond, and X 1 -C is a straight or branched chain 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -OCF3, OCHF2, CN, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, piperazinyl, which may be unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0244] In some embodiments of the compound of Formula II, n is 1 and R a is -CH3, and L 2 is a covalent bond, and X 1is phenyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, and C 1~4 Alkoxy, Fluorinated C 1~4 and substituted with one or more of alkyl (such as -CF3).

[0245] In some embodiments of the compound of Formula II, n is 1 and R a is -CH3, and L 2 is a straight or branched chain C 1~4 is alkyl, and X 1 -C is a straight or branched chain 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy; or X 1 together with the N atom of the carbamate to form a 5-6 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy.

[0246] In some embodiments of the compound of Formula II, n is 1 and R a is -CH3, and L 2 -C is a straight or branched chain 1~4 is alkyl, and X 1 -C is a straight or branched chain 1~6Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 6-membered heterocycloalkyl, which is unsubstituted or 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0247] In some embodiments of the compound of Formula II, n is 1 and R a is -CH3, and L 2 is a straight or branched chain C 1~4 is alkyl, and X 1 is a straight or branched chain -C 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4Alkylhydroxy, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, N-methylpiperazinyl, which may be unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, or C 1~4 substituted with one or more of alkoxy.

[0248] In some embodiments of the compound of Formula II, n is 1 and R a is -CH3, and L 2 is a straight or branched chain C 1~4 is alkyl, and X 1 -C is a straight or branched chain 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -OCF3, OCHF2, CN, and C 1~4 alkoxy or X 1together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, piperazinyl, which may be unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0249] In some embodiments of the compound of Formula II, n is 1 and R a is -CH3, and L 2 is -CH2- and X 1 -C is a straight or branched chain 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 5-6 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy.

[0250] In some embodiments of the compound of Formula II, n is 1 and R a is -CH3, and L 2 is -CH2- and X 1 is a straight or branched chain -C 1~6 Alkyl, -C3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 6-membered heterocycloalkyl, which is unsubstituted or 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0251] In some embodiments of the compound of Formula II, n is 1 and R a is -CH3, and L 2 is -CH2- and X 1 is a straight or branched chain -C 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, N-methylpiperazinyl, which may be unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, or C 1~4 substituted with one or more of alkoxy.

[0252] In some embodiments of the compound of Formula II, n is 1 and R a is -CH3, and L 2 is -CH2- and X 1 is a straight or branched chain -C 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -OCF3, OCHF2, CN, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, piperazinyl, which may be unsubstituted or substituted with halogen, straight or branched chain -C 1~4Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0253] In some embodiments of the compound of Formula II, n is 1 and R a is -CH3, and L 2 is -CH(CH3)- and X 1 -C is a straight or branched chain 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 5-6 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy.

[0254] In some embodiments of the compound of Formula II, n is 1 and R a is -CH3, and L 2 is -CH(CH3)- and X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 6-membered heterocycloalkyl, wherein X1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 6-membered heterocycloalkyl, which is unsubstituted or 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0255] In some embodiments of the compound of Formula II, n is 1 and R a is -CH3, and L 2 is -CH(CH3)- and X 1 is a straight or branched chain -C 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy or X 1together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, N-methylpiperazinyl, which may be unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, or C 1~4 substituted with one or more of alkoxy.

[0256] In some embodiments of the compound of Formula II, n is 1 and R a is -CH3, and L 2 is -CH(CH3)- and X 1 is a straight or branched chain -C 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -OCF3, OCHF2, CN, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, piperazinyl, which may be unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4substituted with one or more of alkoxy.

[0257] In some embodiments of the compound of Formula II, L 3 is a covalent bond, and X 2 is H, C 3~6 cycloalkyl, C6 aryl, 5- to 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~6 Alkyl, -C 1~4 Alkoxy, NH2, NMe2, halogen, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, and -C 1~4 It is substituted with one or more of alkylhydroxy.

[0258] In some embodiments of the compound of Formula II, L 3 is a covalent bond, and X 2 is H, C 3~6 cycloalkyl, C6 aryl, 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2, and halogen (eg, F).

[0259] In some embodiments of the compound of Formula II, L 3 is a covalent bond, and X 2 is H, cyclopropyl, cyclobutyl, azetidinyl, oxetanyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl, C6 aryl, pyridinyl, wherein X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, e.g., methyl, -C 1~4 Substituted with one or more of alkoxy, eg, -OMe, NMe2, and halogen, eg, F.

[0260] In some embodiments of the compound of Formula II, L 3 is a covalent bond, and X 2 is H, cyclopropyl, methyl-cyclopropyl, fluoro-cyclopropyl, difluoro-cyclopropyl, cyclobutyl, C6 aryl, methyl-C6 aryl, fluoro-C6 aryl, methoxy-C6 aryl, pyridinyl, pyrrolidinyl, N-methyl-pyrrolidinyl, methyl-pyrrolidinyl, piperidinyl, N-methylpiperidinyl, methyl-piperidinyl, difluoro-piperidinyl, morpholinyl, N-methyl-morpholinyl, oxetanyl, methyl-oxetanyl, piperazinyl, N-methyl-piperazinyl, azetidinyl, methyl-azetidinyl, N-dimethyl-azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl.

[0261] In some embodiments of the compound of Formula II, L 3 is a covalent bond, and X 2 is H, cyclopropyl, methyl-cyclopropyl, fluoro-cyclopropyl, difluoro-cyclopropyl, cyclobutyl, azetidinyl, NMe2-azetidinyl, oxetanyl, methyl-oxetanyl, pyrrolidinyl, methyl-pyrrolidinyl, piperidinyl, Me-piperidinyl, di-F-piperidinyl, N-Me-piperazinyl, morpholinyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl, C6 aryl, methoxy-C6 aryl, pyridinyl.

[0262] In some embodiments of the compound of Formula II, L 3 is a linear or branched chain C 1~4 is alkyl (such as -CH2-), and X 2 is H, C 3~6 cycloalkyl, C6 aryl, 5- to 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~6 Alkyl, -C 1~4Alkoxy, NH2, NMe2, halogen, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, and -C 1~4 It is substituted with one or more of alkylhydroxy.

[0263] In some embodiments of the compound of Formula II, L 3 is a linear or branched chain C 1~4 is alkyl (such as -CH2-), and X 2 is H, C 3~6 cycloalkyl, C6 aryl, 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2, halogen (eg, F).

[0264] In some embodiments of the compound of Formula II, L 3 is a linear or branched chain C 1~4 is alkyl (such as -CH2-), and X 2 is H, cyclopropyl, cyclobutyl, C6 aryl, pyridinyl, pyrrolidinyl, piperidinyl, morpholinyl, oxetanyl, piperazinyl, azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl, wherein X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2 and halogen.

[0265] In some embodiments of the compound of Formula II, L 3 is a straight or branched chain C 1~4 is alkyl (such as -CH2-), and X 2is H, cyclopropyl, methyl-cyclopropyl, fluoro-cyclopropyl, difluoro-cyclopropyl, cyclobutyl, C6 aryl, methyl-C6 aryl, fluoro-C6 aryl, methoxy-C6 aryl, pyridinyl, pyrrolidinyl, N-methyl-pyrrolidinyl, methyl-pyrrolidinyl, piperidinyl, N-methylpiperidinyl, methyl-piperidinyl, difluoro-piperidinyl, morpholinyl, N-methyl-morpholinyl, oxetanyl, methyl-oxetanyl, piperazinyl, N-methyl-piperazinyl, azetidinyl, methyl-azetidinyl, N-dimethyl-azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl.

[0266] In some embodiments of the compound of Formula II, L 3 is a linear or branched chain C 1~4 is alkyl (such as -CH2-), and X 2 is morpholinyl, N-methyl-morpholinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl.

[0267] In some embodiments of the compound of Formula II, L 3 is -O- and X 2 is H, C 3~6 cycloalkyl, C6 aryl, 5- to 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~6 Alkyl, -C 1~4 Alkoxy, NH2, NMe2, halogen, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, and -C 1~4 It is substituted with one or more of alkylhydroxy.

[0268] In some embodiments of the compound of Formula II, L 3 is -O- and X 2 is H, C 3~6cycloalkyl, C6 aryl, 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2, halogen (eg, F).

[0269] In some embodiments of the compound of Formula II, L 3 is -O- and X 2 is H, cyclopropyl, cyclobutyl, C6 aryl, pyridinyl, pyrrolidinyl, piperidinyl, morpholinyl, oxetanyl, piperazinyl, azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl, wherein X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2 and halogen.

[0270] In some embodiments of the compound of Formula II, L 3 is -O- and X 2 is H, cyclopropyl, methyl-cyclopropyl, fluoro-cyclopropyl, difluoro-cyclopropyl, cyclobutyl, C6 aryl, methyl-C6 aryl, fluoro-C6 aryl, methoxy-C6 aryl, pyridinyl, pyrrolidinyl, N-methyl-pyrrolidinyl, methyl-pyrrolidinyl, piperidinyl, N-methylpiperidinyl, methyl-piperidinyl, difluoro-piperidinyl, morpholinyl, N-methyl-morpholinyl, oxetanyl, methyl-oxetanyl, piperazinyl, N-methyl-piperazinyl, azetidinyl, methyl-azetidinyl, N-dimethyl-azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl.

[0271] In some embodiments of the compound of Formula II, L 3is -O- and X 2 is cyclopropyl, pyrrolidinyl, N-methyl-pyrrolidinyl.

[0272] In some embodiments of the compound of Formula II, L 3 is -O-CH2-, and X 2 is H, C 3~6 cycloalkyl, C6 aryl, 5- to 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~6 Alkyl, -C 1~4 Alkoxy, NH2, NMe2, halogen, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, and -C 1~4 It is substituted with one or more of alkylhydroxy.

[0273] In some embodiments of the compound of Formula II, L 3 is -O-CH2-, and X 2 is H, C 3~6 cycloalkyl, C6 aryl, 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2, and halogen (eg, F).

[0274] In some embodiments of the compound of Formula II, L 3 is -O-CH2-, and X 2 is H, cyclopropyl, cyclobutyl, C6 aryl, pyridinyl, pyrrolidinyl, piperidinyl, morpholinyl, oxetanyl, piperazinyl, azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl, wherein X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4Substituted with one or more of alkoxy, NH2, NMe2 and halogen.

[0275] In some embodiments of the compound of Formula II, L 3 is -O-CH2-, and X 2 is H, cyclopropyl, methyl-cyclopropyl, fluoro-cyclopropyl, difluoro-cyclopropyl, cyclobutyl, C6 aryl, methyl-C6 aryl, fluoro-C6 aryl, methoxy-C6 aryl, pyridinyl, pyrrolidinyl, N-methyl-pyrrolidinyl, methyl-pyrrolidinyl, piperidinyl, N-methylpiperidinyl, methyl-piperidinyl, difluoro-piperidinyl, morpholinyl, N-methyl-morpholinyl, oxetanyl, methyl-oxetanyl, piperazinyl, N-methyl-piperazinyl, azetidinyl, methyl-azetidinyl, N-dimethyl-azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl.

[0276] In some embodiments of the compound of Formula II, L 3 is -O-CH2-, and X 2 is pyrrolidinyl, N-methyl-pyrrolidinyl.

[0277] In some embodiments of the compound of Formula II, L 3 is -O-CH2-CH2- and X 2 is H, C 3~6 cycloalkyl, C6 aryl, 5- to 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain -C 1~4 Alkyl, C 1~6 Alkoxy, NH2, NMe2, halogen, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, and -C 1~4 It is substituted with one or more of alkylhydroxy.

[0278] In some embodiments of the compound of Formula II, L3 is -O-CH2-CH2- and X 2 is H, C 3~6 cycloalkyl, C6 aryl, 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2, and halogen (eg, F).

[0279] In some embodiments of the compound of Formula II, L 3 is -O-CH2-CH2- and X 2 is H, cyclopropyl, cyclobutyl, C6 aryl, pyridinyl, pyrrolidinyl, piperidinyl, morpholinyl, oxetanyl, piperazinyl, azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl, wherein X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2 and halogen.

[0280] In some embodiments of the compound of Formula II, L 3 is -O-CH2-CH2- and X 2is H, cyclopropyl, methyl-cyclopropyl, fluoro-cyclopropyl, difluoro-cyclopropyl, cyclobutyl, C6 aryl, methyl-C6 aryl, fluoro-C6 aryl, methoxy-C6 aryl, pyridinyl, pyrrolidinyl, N-methyl-pyrrolidinyl, methyl-pyrrolidinyl, piperidinyl, N-methylpiperidinyl, methyl-piperidinyl, difluoro-piperidinyl, morpholinyl, N-methyl-morpholinyl, oxetanyl, methyl-oxetanyl, piperazinyl, N-methyl-piperazinyl, azetidinyl, methyl-azetidinyl, N-dimethyl-azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl.

[0281] In some embodiments of the compound of Formula II, L 3 is -O-CH2-CH2- and X 2 is morpholinyl.

[0282] In certain embodiments, the compound of Formula I or II is a compound of Formula III (such as IVa or IVb) or a pharmaceutically acceptable salt or stereoisomer thereof: [ka] During the ceremony, X 1 is a linear or branched chain C 1~6 Alkyl, C 3~6 Cycloalkyl, C 6~10 aryl, 5- to 10-membered heteroaryl, 4- to 8-membered heterocycloalkyl; X 1 is unsubstituted or substituted with halogen, linear or branched C 1~6 Alkyl, straight or branched chain C 1~6 Heteroalkyl, CF3, CHF2, CMeF2, -O-CHF2, -O-(CH2)2-OMe, OCF3, C 1~6 Alkylamino, -CN, -N(H)C(O)-C 1~6 Alkyl, -OC(O)-C 1~6 Alkyl, -OC(O)-C 1~4Alkylamino, -C(O)OC 1~6 Alkyl, -COOH, -C 1~6 AlkylC(O)OH, -C 1~6 Alkyl C(O)OC 1~6 Alkyl, NH2, C 1~4 Alkoxy, and C 1~4 substituted with one or more of alkylhydroxy; or X 1 together with the N atom of the carbamate to form a 4- to 8-membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight- or branched-chain -C 1~6 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, -N(H)C(O)-C 1~6 Alkyl, -OC(O)-C 1~6 Alkyl, -C(O)OC 1~6 Alkyl, -COOH, -C 1~6 AlkylC(O)OH, -C 1~6 Alkyl C(O)OC 1~6 Alkyl, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy; X 2 is H, C 3~6 Cycloalkyl, C 6~10 aryl, 5- to 10-membered heteroaryl, or 4- to 8-membered heterocycloalkyl; and X 2 is unsubstituted or a straight or branched chain C 1~6 Alkyl, -C 1~4 Alkoxy, NH2, NMe2, halogen, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, and C 1~4 substituted with one or more of alkylhydroxy; L 3 is a covalent bond, linear or branched C 1~6 Alkyl, -O-, -C 1~4 is an alkoxy, R a , R b , Rc are, independently of each other, H, straight or branched chain C 1~4 alkyl (e.g., methyl), p is 0 or 1.

[0283] In some embodiments of the compound of Formula III, R a is H. In some embodiments of the compound of Formula III, R a is a straight or branched chain C such as methyl 1~4 It is alkyl.

[0284] In some embodiments of the compound of Formula III, IVa, or IVb, p is 0. In some embodiments of the compound of Formula III, IVa, or IVb, p is 1. In some embodiments of the compound of Formula III, IVa, or IVb, p is 1 and R b and R c is H. In some embodiments of the compound of Formula III, IVa, or IVb, p is 1 and R b is a linear or branched chain C such as methyl 1~4 alkyl, and R c is H.

[0285] In some embodiments of the compound of Formula III, IVa, or IVb, L 3 is a covalent bond. In some embodiments of the compounds of Formula III, IVa, or IVb, L 3 is a straight or branched chain C such as -CH2- 1~4 In some embodiments of the compounds of Formula III, IVa, or IVb, L is alkyl. 3 is —O—. In some embodiments, L 3 is a straight or branched chain C such as -O-CH2-, -O-CH(CH2)2- 1~4 It is an alkoxy.

[0286] In some embodiments of the compound of Formula III, IVa, or IVb, X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C6~10 aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy; or X 1 together with the N atom of the carbamate to form a 5-6 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy.

[0287] In some embodiments of the compound of Formula III, IVa, or IVb, X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 6-membered heterocycloalkyl, which is unsubstituted or 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0288] In some embodiments of the compound of Formula III, IVa, or IVb, X 1 is a straight or branched chain -C 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, N-methylpiperazinyl, which may be unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, or C 1~4 substituted with one or more of alkoxy.

[0289] In some embodiments of the compound of Formula III, IVa, or IVb, X 1 is a straight or branched chain -C 1~6alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -OCF3, OCHF2, CN, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, piperazinyl, which may be unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0290] In some embodiments of the compound of Formula III, IVa, or IVb, X 2 is H, C 3~6 cycloalkyl, C6 aryl, 5- to 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~6 Alkyl, -C 1~4 Alkoxy, NH2, NMe2, halogen, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, and -C 1~4 It is substituted with one or more of alkylhydroxy.

[0291] In some embodiments of the compound of Formula III, IVa, or IVb, X 2 is H, C 3~6 cycloalkyl, C6 aryl, 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2, halogen (eg, F).

[0292] In some embodiments of the compound of Formula II, L 3 is -O-CH2-CH2- and X 2 is H, cyclopropyl, cyclobutyl, C6 aryl, pyridinyl, pyrrolidinyl, piperidinyl, morpholinyl, oxetanyl, piperazinyl, azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl, wherein X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2 and halogen.

[0293] In some embodiments of the compound of Formula III, IVa, or IVb, X 2 is H, cyclopropyl, methyl-cyclopropyl, fluoro-cyclopropyl, difluoro-cyclopropyl, cyclobutyl, C6 aryl, methyl-C6 aryl, fluoro-C6 aryl, methoxy-C6 aryl, pyridinyl, pyrrolidinyl, N-methyl-pyrrolidinyl, methyl-pyrrolidinyl, piperidinyl, N-methylpiperidinyl, methyl-piperidinyl, difluoro-piperidinyl, morpholinyl, N-methyl-morpholinyl, oxetanyl, methyl-oxetanyl, piperazinyl, N-methyl-piperazinyl, azetidinyl, methyl-azetidinyl, N-dimethyl-azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl.

[0294] In some embodiments of the compound of Formula III, R a is H and X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy; or X 1 together with the N atom of the carbamate to form a 5-6 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy.

[0295] In some embodiments of the compound of Formula III, R a is H and X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 alkoxy, or X 1together with the N atom of the carbamate to form a 6-membered heterocycloalkyl, which is unsubstituted or 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0296] In some embodiments of the compound of Formula III, R a is H and X 1 is a straight or branched chain -C 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, N-methylpiperazinyl, which may be unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, or C1~4 substituted with one or more of alkoxy.

[0297] In some embodiments of the compound of Formula III, R a is H and X 1 is a straight or branched chain -C 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -OCF3, OCHF2, CN, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, piperazinyl, which may be unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0298] In some embodiments of the compound of Formula III, R a is -CH3 and X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, wherein X 1is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy; or X 1 together with the N atom of the carbamate to form a 5-6 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy.

[0299] In some embodiments of the compound of Formula III, R a is -CH3 and X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 6-membered heterocycloalkyl, which is unsubstituted or 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0300] In some embodiments of the compound of Formula III, Ra is -CH3 and X 1 is a straight or branched chain -C 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, N-methylpiperazinyl, which may be unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, or C 1~4 substituted with one or more of alkoxy.

[0301] In some embodiments of the compound of Formula III, R a is -CH3 and X 1 is a straight or branched chain -C 1~6alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -OCF3, OCHF2, CN, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, piperazinyl, which may be unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0302] In some embodiments of the compound of Formula III, R a is -CH3 and X 1 is phenyl, which is unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl (methyl, etc.), fluorinated C 1~4 alkoxy (such as -OCF3).

[0303] In some embodiments of the compound of Formula III, Va, or IVb, p is 0 and X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy; or X 1 together with the N atom of the carbamate to form a 5-6 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy.

[0304] In some embodiments of the compound of Formula III, IVa, or IVb, p is 0 and X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 6-membered heterocycloalkyl, which is unsubstituted or 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN and C 1~4 substituted with one or more of alkoxy.

[0305] In some embodiments of the compound of Formula III, IVa, or IVb, p is 0 and X 1 is a straight or branched chain -C 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, N-methylpiperazinyl, which may be unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, or C 1~4 substituted with one or more of alkoxy.

[0306] In some embodiments of the compound of Formula III, IVa, or IVb, p is 0 and X 1 is a straight or branched chain -C 1~6alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -OCF3, OCHF2, CN, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, piperazinyl, which may be unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0307] In some embodiments of the compound of Formula III, IVa, or IVb, p is 1 and R b , R c is H and X 1 -C is a straight or branched chain 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4Alkylhydroxy, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 5-6 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy.

[0308] In some embodiments of the compound of Formula III, IVa, or IVb, p is 1 and R b , R c is H and X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 6-membered heterocycloalkyl, which is unsubstituted or 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0309] In some embodiments of compounds of Formula III, IVa, or IVb, p is 1 and R b , R c is H and X 1 is a straight or branched chain -C 1~6alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, N-methylpiperazinyl, which may be unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, or C 1~4 substituted with one or more of alkoxy.

[0310] In some embodiments of the compound of Formula III, IVa, or IVb, p is 1 and R b , R c is H and X 1 is a straight or branched chain -C 1~6alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -OCF3, OCHF2, CN, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, piperazinyl, which may be unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0311] In some embodiments of the compound of Formula III, IVa, or IVb, p is 1 and R b , R c is H and X 1 is phenyl, which is unsubstituted or is selected from the group consisting of halogen, straight-chain or branched -C 1~4 Alkyl, and C 1~4 and is substituted with one or more of -alkoxy, and is preferably unsubstituted or substituted with -OMe.

[0312] In some embodiments of the compound of Formula III, IVa, or IVb, p is 1 and R b is -CH3 and R c is H and X 1-C is a straight or branched chain 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 5-6 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy.

[0313] In some embodiments of the compound of Formula III, IVa, or IVb, p is 1 and R b is -CH3 and R c is H and X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 alkoxy, or X 1together with the N atom of the carbamate to form a 6-membered heterocycloalkyl, which is unsubstituted or 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0314] In some embodiments of compounds of Formula III, IVa, or IVb, p is 1 and R b is -CH3 and R c is H and X 1 is a straight or branched chain -C 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, N-methylpiperazinyl, which may be unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, or C 1~4 substituted with one or more of alkoxy.

[0315] In some embodiments of the compound of Formula III, IVa, or IVb, p is 1 and R b is -CH3 and R c is H and X 1 is a straight or branched chain -C 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -OCF3, OCHF2, CN, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, piperazinyl, which may be unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0316] In some embodiments of the compound of Formula III, IVa, or IVb, p is 1 and R b is -CH3 and R c is H and X 1is phenyl, which is unsubstituted or is selected from the group consisting of halogen, straight-chain or branched -C 1~4 Alkyl, and C 1~4 and is substituted with one or more of -alkoxy, and is preferably unsubstituted or substituted with -OMe.

[0317] In some embodiments of the compound of Formula III, IVa, or IVb, p is 0 and X 2 is H, C 3~6 cycloalkyl, C6 aryl, 5- to 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~6 Alkyl, -C 1~4 Alkoxy, NH2, NMe2, halogen, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, and -C 1~4 It is substituted with one or more of alkylhydroxy.

[0318] In some embodiments of the compound of Formula III, IVa, or IVb, p is 0 and X 2 is H, C 3~6 cycloalkyl, C6 aryl, 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2, and halogen (eg, F).

[0319] In some embodiments of the compound of Formula III, IVa, or IVb, p is 0 and X 2 is H, cyclopropyl, cyclobutyl, C6 aryl, pyridinyl, pyrrolidinyl, piperidinyl, morpholinyl, oxetanyl, piperazinyl, azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl, wherein X 2 is unsubstituted or a straight or branched chain C1~4 Alkyl (e.g., Me), -C 1~4 Substituted with one or more of alkoxy (eg, -OMe), NH2, NMe2, and halogen (eg, F).

[0320] In some embodiments of the compound of Formula III, IVa, or IVb, p is 0 and X 2 is H, cyclopropyl, methyl-cyclopropyl, fluoro-cyclopropyl, difluoro-cyclopropyl, cyclobutyl, C6 aryl, methyl-C6 aryl, fluoro-C6 aryl, methoxy-C6 aryl, pyridinyl, pyrrolidinyl, N-methyl-pyrrolidinyl, methyl-pyrrolidinyl, piperidinyl, N-methylpiperidinyl, methyl-piperidinyl, difluoro-piperidinyl, morpholinyl, N-methyl-morpholinyl, oxetanyl, methyl-oxetanyl, piperazinyl, N-methyl-piperazinyl, azetidinyl, methyl-azetidinyl, N-dimethyl-azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl.

[0321] In some embodiments of the compound of Formula III, IVa, or IVb, p is 0 and X 2 is H, cyclopropyl, methyl-cyclopropyl, fluoro-cyclopropyl, difluoro-cyclopropyl, cyclobutyl, azetidinyl, NMe2-azetidinyl, oxetanyl, methyl-oxetanyl, pyrrolidinyl, methyl-pyrrolidinyl, piperidinyl, Me-piperidinyl, di-F-piperidinyl, N-Me-piperazinyl, morpholinyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl, C6 aryl, methoxy-C6 aryl, pyridinyl.

[0322] In some embodiments of the compound of Formula III, IVa, or IVb, p is 1 and R b and R c is H and X 2 is H, C 3~6cycloalkyl, C6 aryl, 5- to 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~6 Alkyl, -C 1~4 Alkoxy, NH2, NMe2, halogen, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, and -C 1~4 It is substituted with one or more of alkylhydroxy.

[0323] In some embodiments of the compound of Formula III, IVa, or IVb, p is 1 and R b and R c is H and X 2 is H, C 3~6 cycloalkyl, C6 aryl, 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2, and halogen (eg, F).

[0324] In some embodiments of the compound of Formula III, IVa, or IVb, p is 1 and R b and R c is H and X 2 is H, cyclopropyl, cyclobutyl, C6 aryl, pyridinyl, pyrrolidinyl, piperidinyl, morpholinyl, oxetanyl, piperazinyl, azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl, wherein X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2 and halogen.

[0325] In some embodiments of the compound of Formula III, IVa, or IVb, p is 1 and R b and Rc is H and X 2 is H, cyclopropyl, methyl-cyclopropyl, fluoro-cyclopropyl, difluoro-cyclopropyl, cyclobutyl, C6 aryl, methyl-C6 aryl, fluoro-C6 aryl, methoxy-C6 aryl, pyridinyl, pyrrolidinyl, N-methyl-pyrrolidinyl, methyl-pyrrolidinyl, piperidinyl, N-methylpiperidinyl, methyl-piperidinyl, difluoro-piperidinyl, morpholinyl, N-methyl-morpholinyl, oxetanyl, methyl-oxetanyl, piperazinyl, N-methyl-piperazinyl, azetidinyl, methyl-azetidinyl, N-dimethyl-azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl.

[0326] In some embodiments of the compound of Formula III, IVa, or IVb, p is 1 and R b and R c is H and X 2 is phenyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, and C 1~4 and is substituted with one or more of -alkoxy, and is preferably unsubstituted or substituted with -OMe.

[0327] In some embodiments of the compound of Formula III, IVa, or IVb, p is 1 and R b is CH3 and R c is H and X 2 is H, C 3~6 cycloalkyl, C6 aryl, 5- to 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~6 Alkyl, -C 1~4 Alkoxy, NH2, NMe2, halogen, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, and -C 1~4 It is substituted with one or more of alkylhydroxy.

[0328] In some embodiments of the compound of Formula III, IVa, or IVb, p is 1 and R b is CH3 and R c is H and X 2 is H, C 3~6 cycloalkyl, C6 aryl, 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2, and halogen (eg, F).

[0329] In some embodiments of the compound of Formula II, L 3 is -O-CH2-CH2- and X 2 is H, cyclopropyl, cyclobutyl, C6 aryl, pyridinyl, pyrrolidinyl, piperidinyl, morpholinyl, oxetanyl, piperazinyl, azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl, wherein X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2 and halogen.

[0330] In some embodiments of the compound of Formula III, IVa, or IVb, p is 1 and R b is CH3 and R c is H and X 2is H, cyclopropyl, methyl-cyclopropyl, fluoro-cyclopropyl, difluoro-cyclopropyl, cyclobutyl, C6 aryl, methyl-C6 aryl, fluoro-C6 aryl, methoxy-C6 aryl, pyridinyl, pyrrolidinyl, N-methyl-pyrrolidinyl, methyl-pyrrolidinyl, piperidinyl, N-methylpiperidinyl, methyl-piperidinyl, difluoro-piperidinyl, morpholinyl, N-methyl-morpholinyl, oxetanyl, methyl-oxetanyl, piperazinyl, N-methyl-piperazinyl, azetidinyl, methyl-azetidinyl, N-dimethyl-azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl.

[0331] In some embodiments of the compound of Formula III, IVa, or IVb, p is 1 and R b is CH3 and R c is H and X 2 is phenyl.

[0332] In some embodiments of the compound of Formula III, R a is H, p is 0, and X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy; or X 1 together with the N atom of the carbamate to form a 5-6 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy.

[0333] In some embodiments of the compound of Formula III, R a is H, p is 0, and X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 6-membered heterocycloalkyl, which is unsubstituted or 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0334] In some embodiments of the compound of Formula III, R a is H, p is 0, and X 1 is a straight or branched chain -C 1~6alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, N-methylpiperazinyl, which may be unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, or C 1~4 substituted with one or more of alkoxy.

[0335] In some embodiments of the compound of Formula III, R a is H, p is 0, and X 1 is a straight or branched chain -C 1~6alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -OCF3, OCHF2, CN, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, piperazinyl, which may be unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0336] In some embodiments of the compound of Formula III, R a is H, p is 1, and R b and R c is H and X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4Alkylhydroxy, and C 1~4 alkoxy; or X 1 together with the N atom of the carbamate to form a 5-6 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy.

[0337] In some embodiments of the compound of Formula III, R a is H, p is 1, and R b and R c is H and X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 6-membered heterocycloalkyl, which is unsubstituted or 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0338] In some embodiments of the compound of Formula III, R a is H, p is 1, and R b and R c is H and X 1 is a straight or branched chain -C1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, N-methylpiperazinyl, which may be unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, or C 1~4 substituted with one or more of alkoxy.

[0339] In some embodiments of the compound of Formula III, R a is H, p is 1, and R b and R c is H and X 1 is a straight or branched chain -C 1~6alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -OCF3, OCHF2, CN, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, piperazinyl, which may be unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0340] In some embodiments of the compound of Formula III, R a is H, p is 1, and R b and R c is H and X 1 is phenyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, and C 1~4 and is substituted with one or more of -alkoxy, and is preferably unsubstituted or substituted with -OMe.

[0341] In some embodiments of the compound of Formula III, R a is H, p is 1, and R b is CH3 and R cis H and X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy; or X 1 together with the N atom of the carbamate to form a 5-6 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy.

[0342] In some embodiments of the compound of Formula III, R a is H, p is 1, and R b is CH3 and R c is H and X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 alkoxy, or X 1together with the N atom of the carbamate to form a 6-membered heterocycloalkyl, which is unsubstituted or 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0343] In some embodiments of the compound of Formula III, R a is H, p is 1, and R b is CH3 and R c is H and X 1 is a straight or branched chain -C 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, N-methylpiperazinyl, which may be unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, or C 1~4 substituted with one or more of alkoxy.

[0344] In some embodiments of the compound of Formula III, R a is H, p is 1, and R b is CH3 and R c is H and X 1 is a straight or branched chain -C 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -OCF3, OCHF2, CN, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, piperazinyl, which may be unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0345] In some embodiments of the compound of Formula III, R a is H, p is 1, and R b is CH3 and R c is H and X1 is phenyl.

[0346] In some embodiments of the compound of Formula III, R a is CH3, p is 0, and X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy; or X 1 together with the N atom of the carbamate to form a 5-6 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy.

[0347] In some embodiments of the compound of Formula III, R a is CH3, p is 0, and X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4alkoxy, or X 1 together with the N atom of the carbamate to form a 6-membered heterocycloalkyl, which is unsubstituted or 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0348] In some embodiments of the compound of Formula III, R a is CH3, p is 0, and X 1 is a straight or branched chain -C 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, N-methylpiperazinyl, which may be unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, or C 1~4 substituted with one or more of alkoxy.

[0349] In some embodiments of the compound of Formula III, R a is CH3, p is 0, and X 1 is a straight or branched chain -C 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -OCF3, OCHF2, CN, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, piperazinyl, which may be unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0350] In some embodiments of the compound of Formula III, R a is -CH3, p is 0, and X 1 is phenyl, which is unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4Alkyl (methyl, etc.), fluorinated C 1~4 alkoxy (such as -OCF3).

[0351] In some embodiments of the compound of Formula III, R a is CH3, p is 1, and R b and R c is H and X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy; or X 1 together with the N atom of the carbamate to form a 5-6 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy.

[0352] In some embodiments of the compound of Formula III, R a is CH3, p is 1, and R b and R c is H and X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 6-membered heterocycloalkyl, wherein X1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 6-membered heterocycloalkyl, which is unsubstituted or 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0353] In some embodiments of the compound of Formula III, R a is CH3, p is 1, and R b and R c is H and X 1 is a straight or branched chain -C 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy or X 1together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, N-methylpiperazinyl, which may be unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, or C 1~4 substituted with one or more of alkoxy.

[0354] In some embodiments of the compound of Formula III, R a is CH3, p is 1, and R b and R c is H and X 1 is a straight or branched chain -C 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -OCF3, OCHF2, CN, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, piperazinyl, which may be unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4substituted with one or more of alkoxy.

[0355] In some embodiments of the compound of Formula III, R a is CH3, p is 1, and R b is CH3 and R c is H and X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, wherein X 1 is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy; or X 1 together with the N atom of the carbamate to form a 5-6 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 substituted with one or more of alkoxy.

[0356] In some embodiments of the compound of Formula III, R a is CH3, p is 1, and R b is CH3 and R c is H and X 1 is a straight or branched chain -C 1~6 Alkyl, -C 3~6 Cycloalkyl, -C 6~10 aryl, 5- to 10-membered heteroaryl, 6-membered heterocycloalkyl, wherein X 1is unsubstituted or is a halogen, a straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 alkoxy, or X 1 together with the N atom of the carbamate to form a 6-membered heterocycloalkyl, which is unsubstituted or 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C 1~4 substituted with one or more of alkoxy.

[0357] In some embodiments of the compound of Formula III, R a is CH3, p is 1, and R b is CH3 and R c is H and X 1 is a straight or branched chain -C 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, and C 1~4 alkoxy or X 1together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl, N-methylpiperazinyl, which may be unsubstituted or substituted with halogen (Cl, F, etc.), straight or branched -C 1~4 Alkyl, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, C 1~6 Alkylamino, -CN, NH2, C 1~4 Alkylhydroxy, or C 1~4 substituted with one or more of alkoxy.

[0358] In some embodiments of the compound of Formula III, R a is CH3, p is 1, and R b is CH3 and R c is H and X 1 is a straight or branched chain -C 1~6 alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[1.1.1]pentyl, piperidinyl, 1,3-dioxanyl, phenyl, dihydroindenyl, isothiazolyl, pyridinyl, pyrazinyl, pyridazinyl, pyrimidinyl, 2,2-difluoro-1,3-benzodioxolyl, 2,3-dihydrobenzofuryl, 2-methyl-2,3-dihydrobenzofuryl, 3-methyl-2,3-dihydrobenzofuryl, 3,3-dimethyl-2,3-dihydrobenzofuryl, 2,3-dimethyl-2,3-dihydrobenzofuryl, cyclopentenopyridine, benzodihydropyran, dihydropyrano-pyridine, wherein X 1 is unsubstituted or is substituted with halogen (Cl, F, etc.), straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, -OCF3, OCHF2, CN, and C 1~4 alkoxy or X 1 together with the N atom of the carbamate to form pyrrolidinyl, piperidinyl, piperazinyl, which may be unsubstituted or substituted with halogen, straight or branched chain -C 1~4 Alkyl, CF3, CHF2, CMeF2, OCF3, OCHF2, CN, and C1~4 substituted with one or more of alkoxy.

[0359] In some embodiments of the compound of Formula III, IVa, or IVb, L 3 is a covalent bond, and X 2 is H, C 3~6 cycloalkyl, C6 aryl, 5- to 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~6 Alkyl, -C 1~4 Alkoxy, NH2, NMe2, halogen, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, and -C 1~4 It is substituted with one or more of alkylhydroxy.

[0360] In some embodiments of the compound of Formula III, IVa, or IVb, L 3 is a covalent bond, and X 2 is H, C 3~6 cycloalkyl, C6 aryl, 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2, and halogen (eg, F).

[0361] In some embodiments of the compound of Formula III, IVa, or IVb, L 3 is a covalent bond, and X 2 is H, cyclopropyl, cyclobutyl, C6 aryl, pyridinyl, pyrrolidinyl, piperidinyl, morpholinyl, oxetanyl, piperazinyl, azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl, wherein X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4Substituted with one or more of alkoxy, NH2, NMe2 and halogen.

[0362] In some embodiments of the compound of Formula III, IVa, or IVb, L 3 is a covalent bond, and X 2 is H, cyclopropyl, cyclobutyl, azetidinyl, oxetanyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl, C6 aryl, pyridinyl, wherein X 2 is unsubstituted or a straight or branched chain C 1~6 Alkyl, e.g., methyl, -C 1~4 Substituted with one or more of alkoxy, eg, -OMe, NMe2, and halogen, eg, F.

[0363] In some embodiments of the compound of Formula III, IVa, or IVb, p is 1 and L 3 is a covalent bond, and X 2 is H, cyclopropyl, methyl-cyclopropyl, fluoro-cyclopropyl, difluoro-cyclopropyl, cyclobutyl, C6 aryl, methyl-C6 aryl, fluoro-C6 aryl, methoxy-C6 aryl, pyridinyl, pyrrolidinyl, N-methyl-pyrrolidinyl, methyl-pyrrolidinyl, piperidinyl, N-methylpiperidinyl, methyl-piperidinyl, difluoro-piperidinyl, morpholinyl, N-methyl-morpholinyl, oxetanyl, methyl-oxetanyl, piperazinyl, N-methyl-piperazinyl, azetidinyl, methyl-azetidinyl, N-dimethyl-azetidinyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl.

[0364] In some embodiments of the compound of Formula III, IVa, or IVb, L 3 is a covalent bond, and X 2is H, cyclopropyl, methyl-cyclopropyl, fluoro-cyclopropyl, difluoro-cyclopropyl, cyclobutyl, azetidinyl, NMe2-azetidinyl, oxetanyl, methyl-oxetanyl, pyrrolidinyl, methyl-pyrrolidinyl, piperidinyl, Me-piperidinyl, di-F-piperidinyl, N-Me-piperazinyl, morpholinyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl, C6 aryl, methoxy-C6 aryl, pyridinyl.

[0365] In some embodiments of the compound of Formula III, IVa, or IVb, L 3 is a linear or branched chain C 1~4 is alkyl (such as -CH2-), and X 2 is H, C 3~6 cycloalkyl, C6 aryl, 5- to 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~6 Alkyl, -C 1~4 Alkoxy, NH2, NMe2, halogen, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, and -C 1~4 It is substituted with one or more of alkylhydroxy.

[0366] In some embodiments of the compound of Formula III, IVa, or IVb, L 3 is a linear or branched chain C 1~4 is alkyl (such as -CH2-), and X 2 is H, C 3~6 cycloalkyl, C6 aryl, 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2, and halogen (eg, F).

[0367] In some embodiments of the compound of Formula III, IVa, or IVb, L 3is a linear or branched chain C 1~4 is alkyl (such as -CH2-), and X 2 is H, cyclopropyl, cyclobutyl, C6 aryl, pyridinyl, pyrrolidinyl, piperidinyl, morpholinyl, oxetanyl, piperazinyl, azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl, wherein X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2 and halogen.

[0368] In some embodiments of the compound of Formula III, IVa, or IVb, L 3 is a straight or branched chain C 1~4 is alkyl (such as -CH2-), and X 2 is H, cyclopropyl, methyl-cyclopropyl, fluoro-cyclopropyl, difluoro-cyclopropyl, cyclobutyl, C6 aryl, methyl-C6 aryl, fluoro-C6 aryl, methoxy-C6 aryl, pyridinyl, pyrrolidinyl, N-methyl-pyrrolidinyl, methyl-pyrrolidinyl, piperidinyl, N-methylpiperidinyl, methyl-piperidinyl, difluoro-piperidinyl, morpholinyl, N-methyl-morpholinyl, oxetanyl, methyl-oxetanyl, piperazinyl, N-methyl-piperazinyl, azetidinyl, methyl-azetidinyl, N-dimethyl-azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl.

[0369] In some embodiments of the compound of Formula III, IVa, or IVb, L 3 is a linear or branched chain C 1~4 is alkyl (such as -CH2-), and X 2 is morpholinyl, N-methyl-morpholinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl.

[0370] In some embodiments of the compound of Formula III, IVa, or IVb, L 3 is -O- and X 2 is H, C 3~6 cycloalkyl, C6 aryl, 5- to 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~6 Alkyl, -C 1~4 Alkoxy, NH2, NMe2, halogen, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, and -C 1~4 It is substituted with one or more of alkylhydroxy.

[0371] In some embodiments of the compound of Formula III, IVa, or IVb, L 3 is -O- and X 2 is H, C 3~6 cycloalkyl, C6 aryl, 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2, and halogen (eg, F).

[0372] In some embodiments of the compound of Formula III, IVa, or IVb, L 3 is -O- and X 2 is H, cyclopropyl, cyclobutyl, C6 aryl, pyridinyl, pyrrolidinyl, piperidinyl, morpholinyl, oxetanyl, piperazinyl, azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl, wherein X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2 and halogen.

[0373] In some embodiments of the compound of Formula III, IVa, or IVb, L 3 is -O- and X 2 is H, cyclopropyl, methyl-cyclopropyl, fluoro-cyclopropyl, difluoro-cyclopropyl, cyclobutyl, C6 aryl, methyl-C6 aryl, fluoro-C6 aryl, methoxy-C6 aryl, pyridinyl, pyrrolidinyl, N-methyl-pyrrolidinyl, methyl-pyrrolidinyl, piperidinyl, N-methylpiperidinyl, methyl-piperidinyl, difluoro-piperidinyl, morpholinyl, N-methyl-morpholinyl, oxetanyl, methyl-oxetanyl, piperazinyl, N-methyl-piperazinyl, azetidinyl, methyl-azetidinyl, N-dimethyl-azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl.

[0374] In some embodiments of the compound of Formula III, IVa, or IVb, L 3 is -O- and X 2 is cyclopropyl, pyrrolidinyl, N-methyl-pyrrolidinyl.

[0375] In some embodiments of the compound of Formula III, IVa, or IVb, L 3 is -O-CH2-, and X 2 is H, C 3~6 cycloalkyl, C6 aryl, 5- to 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~6 Alkyl, -C 1~4 Alkoxy, NH2, NMe2, halogen, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, and -C 1~4 It is substituted with one or more of alkylhydroxy.

[0376] In some embodiments of the compound of Formula III, IVa, or IVb, L 3is -O-CH2-, and X 2 is H, C 3~6 cycloalkyl, C6 aryl, 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2, and halogen (eg, F).

[0377] In some embodiments of the compound of Formula III, IVa, or IVb, L 3 is -O-CH2-, and X 2 is H, cyclopropyl, cyclobutyl, C6 aryl, pyridinyl, pyrrolidinyl, piperidinyl, morpholinyl, oxetanyl, piperazinyl, azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl, wherein X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2 and halogen.

[0378] In some embodiments of the compound of Formula III, IVa, or IVb, L 3 is -O-CH2-, and X 2is H, cyclopropyl, methyl-cyclopropyl, fluoro-cyclopropyl, difluoro-cyclopropyl, cyclobutyl, C6 aryl, methyl-C6 aryl, fluoro-C6 aryl, methoxy-C6 aryl, pyridinyl, pyrrolidinyl, N-methyl-pyrrolidinyl, methyl-pyrrolidinyl, piperidinyl, N-methylpiperidinyl, methyl-piperidinyl, difluoro-piperidinyl, morpholinyl, N-methyl-morpholinyl, oxetanyl, methyl-oxetanyl, piperazinyl, N-methyl-piperazinyl, azetidinyl, methyl-azetidinyl, N-dimethyl-azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl.

[0379] In some embodiments of the compound of Formula III, IVa, or IVb, L 3 is -O-CH2-, and X 2 is pyrrolidinyl, N-methyl-pyrrolidinyl.

[0380] In some embodiments of the compound of Formula III, IVa, or IVb, L 3 is -O-CH2-CH2- and X 2 is H, C 3~6 cycloalkyl, C6 aryl, 5- to 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~6 Alkyl, -C 1~4 Alkoxy, NH2, NMe2, halogen, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, and -C 1~4 It is substituted with one or more of alkylhydroxy.

[0381] In some embodiments of the compound of Formula III, IVa, or IVb, L 3 is -O-CH2-CH2- and X 2 is H, C 3~6 cycloalkyl, C6 aryl, 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2, and halogen (eg, F).

[0382] In some embodiments of the compound of Formula III, IVa, or IVb, L 3 is -O-CH2-CH2- and X 2 is H, cyclopropyl, cyclobutyl, C6 aryl, pyridinyl, pyrrolidinyl, piperidinyl, morpholinyl, oxetanyl, piperazinyl, azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl, wherein X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2 and halogen.

[0383] In some embodiments of the compound of Formula III, IVa, or IVb, L 3 is -O-CH2-CH2- and X 2 is H, cyclopropyl, methyl-cyclopropyl, fluoro-cyclopropyl, difluoro-cyclopropyl, cyclobutyl, C6 aryl, methyl-C6 aryl, fluoro-C6 aryl, methoxy-C6 aryl, pyridinyl, pyrrolidinyl, N-methyl-pyrrolidinyl, methyl-pyrrolidinyl, piperidinyl, N-methylpiperidinyl, methyl-piperidinyl, difluoro-piperidinyl, morpholinyl, N-methyl-morpholinyl, oxetanyl, methyl-oxetanyl, piperazinyl, N-methyl-piperazinyl, azetidinyl, methyl-azetidinyl, N-dimethyl-azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl.

[0384] In some embodiments of the compound of Formula III, IVa, or IVb, L3 is -O-CH2-CH2- and X 2 is morpholinyl.

[0385] In some embodiments of the compound of Formula III, IVa, or IVb, X 1 is a C6 aryl or 6-membered heteroaryl, such as pyridine, pyridazine, pyrimidine, or pyrazine. In some embodiments of compounds of Formula III, IVa, or IVb, X 1 is a partially aromatic 6-10 membered aryl or heteroaryl, for example, a 5-6 or 6-6 fused ring system in which the 6-membered ring is a phenyl or pyridyl group. In some embodiments of compounds of Formula III, IVa, or IVb, X 1 is C 1~6 Alkyl, C 3~6 In some embodiments of the compound of Formula III, IVa, or IVb, X is a cycloalkyl, a 4- to 8-membered heterocycloalkyl, or a 4- to 8-membered heterocycloalkyl. 1 together with the N atom of the carbamate to form a 4-8 membered heterocycloalkyl. Thus, in some embodiments, the compound of Formula I is a compound of Formula V, VI, or VII, or a pharmaceutically acceptable salt or stereoisomer thereof: [ka] During the ceremony, w 1 , w 2 , w 3 , w 4 , w 5 one or two of which are independently selected from C, N, S, and O, and the remaining w 1 , w 2 , w 3 , w 4 , w 5 is C, w 6 , w 7 , w 8 , w 9 One or two of the groups are selected from C and O, and the remaining w 6 , w 7 , w 8 , w 9 is C and w 10, w 11 are independently selected from C and N; L 1 is a covalent bond, linear or branched C 1~6 is alkyl, and L 2 is a covalent bond, linear or branched C 1~6 is alkyl, R 1 , R 2 , R 3 , R 4 are, independently of each other, H, linear or branched -C 1~6 Alkyl, linear or branched C 1~6 Heteroalkyl, -C 1~4 Alkoxy, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, -C 1~6 Alkylamino, -CN, -OC(O)-C 1~6 Alkyl, -N(H)C(O)-C 1~6 Alkyl, -C(O)OC 1~6 Alkyl, -COOH, -C 1~6 AlkylC(O)OH, -C 1~6 Alkyl C(O)OC 1~6 Alkyl, NH2, -C 1~4 alkylhydroxy and halogen such as F, Cl or Br, e.g., F or Cl, or a group of formula -L 3 -X 2 wherein L 3 is a covalent bond, linear or branched C 1~6 Alkyl, -O-, -C 1~4 is an alkoxy group, and X is an alkoxy group. 2 is C 3~6 Cycloalkyl, C 6~10 aryl, 5- to 10-membered heteroaryl, or 4- to 8-membered heterocycloalkyl; and X 2 is unsubstituted or a straight or branched chain C 1~6 Alkyl, -C 1~4 Alkoxy, NH2, NMe2, halogen, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, and -C 1~4 substituted with one or more alkylhydroxy groups; R 5 , R 6 , R 7 R 8 are, independently of each other, H, linear or branched C 1~4 selected from alkyl, such as methyl, and halogen, such as F or Cl, such as F; Z is a straight or branched chain -C 1~6 Alkyl, -C 3~6 cycloalkyl, 4- to 8-membered heterocycloalkyl, and Z is unsubstituted or C 1~4 substituted with alkyl, C6 aryl, C6 aryloxy, 6-membered heteroaryl, or CF3, or Z together with the N atom of the carbamate is unsubstituted, or C 1~4 Forming a 4-8 membered heterocycloalkyl substituted with alkyl, C6 aryl, C6 aryloxy, 6 membered heteroaryl or CF3, q is 0 or 1.

[0386] In some embodiments of the compounds of Formula V, VI, or VII, L 1 is a linear or branched chain C 1~4 In some embodiments of the compounds of Formula V, VI, or VII, L is alkyl. 1 In some embodiments of the compound of Formula V, VI, or VII, L 1 is -CH(CH3)-.

[0387] In some embodiments of the compounds of Formula V, VI, or VII, L 2 is a covalent bond. In some embodiments of the compound of Formula V, VI, or VII, L 2 is a straight or branched chain C 1~4 In some embodiments of the compounds of Formula V, VI, or VII, L is alkyl. 2 In some embodiments of the compound of Formula V, VI, or VII, L 2 is -CH(CH3)-.

[0388] In some embodiments of the compounds of Formula V, VI, or VII, L3 is a covalent bond. In some embodiments of the compounds of Formula V, VI, or VII, L 3 is a straight or branched chain C such as -CH2- 1~4 In some embodiments of the compounds of Formula V, VI, or VII, L is alkyl. 3 In some embodiments of the compound of Formula V, VI, or VII, L 3 is a straight or branched chain C such as -O-CH2-, -O-(CH2)2 1~4 It is an alkoxy.

[0389] In some embodiments of the compound of Formula VI, w 10 and w 11 One of is C and the other is N. In some embodiments of the compound of Formula VI, q is 1 and w 10 and w 11 One of is C and the other is N. In some embodiments of the compound of Formula VI, q is 0 and w 10 and w 11 One is C and the other is N.

[0390] In some embodiments of the compound of Formula VI, q is 0 and w 8 is C. In some embodiments of the compound of Formula VI, q is 0 and w 8 is C and w 6 , w 7 is selected from C and O. In some embodiments of the compound of Formula VI, q is 0 and w 8 is C and w 6 , w 7 is O. In some embodiments of the compound of Formula VI, q is 0 and w 8 is C and w 6 , w 7 One of the two is C, and w 6 , w 7 The other is O.

[0391] In some embodiments of the compound of Formula VI, q is 1 and w 6 , w 7 , w 8 , w9 is C. In some embodiments of the compound of Formula VI, q is 1 and w 6 is O and w 7 , w 8 , w 9 is C. In some embodiments of the compound of Formula VI, q is 1 and w 7 is O and w 6 , w 8 , w 9 is C. In some embodiments of the compound of Formula VI, q is 1 and w 8 is O and w 6 , w 7 , w 9 is C. In some embodiments of the compound of Formula VI, q is 1 and w 9 is O and w 6 , w 7 , w 8 is C.

[0392] In some embodiments of the compound of Formula V, q is 1 and w 1 , w 2 , w 3 , w 4 , w 5 is C. In some embodiments of the compound of Formula V, q is 1 and w 1 Or w 2 Or w 3 Or w 4 Or w 5 is N and w 1 , w 2 , w 3 , w 4 , w 5 The remaining four of are C. In some embodiments of the compound of Formula V, q is 1 and w 1 , w 2 Or w 1 , w 3 Or w 1 , w 4 Or w 1 , w 5 Or w 2 , w 3 is N and w 1 , w 2 , w 3 , w 4, w 5 The remaining three are C.

[0393] In some embodiments of the compound of Formula V, q is 0 and w 1 , w 2 , w 3 , w 5 is C. In some embodiments of the compound of Formula V, q is 0 and w 1 Or w 2 Or w 3 Or w 5 is selected from N, S and O, 1 , w 2 , w 3 , w 5 The remaining four of are C. In some embodiments of the compound of Formula V, q is 0 and w 1 , w 2 Or w 1 , w 3 Or w 1 , w 5 is selected from N, S, and O; 1 , w 2 , w 3 , w 5 The remaining two are C.

[0394] In some embodiments of the compound of Formula V, R 1 , R 2 , R 3 , and R 4 are, independently of each other, H, straight-chain or branched -C 1~6 Alkyl, straight or branched chain C 1~6 Heteroalkyl, -C 1~4 Alkoxy, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, -C 1~6 Alkylamino, -CN, -OC(O)-C 1~6 Alkyl, -N(H)C(O)-C 1~6 Alkyl, -C(O)OC 1~6 Alkyl, -COOH, -C 1~6 AlkylC(O)OH, -C 1~6 Alkyl C(O)OC 1~6 Alkyl, NH2, -C 1~4It is selected from alkylhydroxy, and halogen, such as F, Cl or Br, for example F or Cl.

[0395] In some embodiments of the compound of Formula V, R 1 , R 2 , R 3 , and R 4 are, independently of each other, H, straight-chain or branched -C 1~6 Alkyl, -C 1~4 It is selected from alkoxy, CF3, CHF2, CMeF2, OCF3, OCHF2, -CN, and halogen, such as F, Cl or Br, for example F or Cl.

[0396] In some embodiments of the compound of Formula V, R 1 is H and R 2 , R 3 , R 4 are, independently of each other, H, straight-chain or branched -C 1~6 Alkyl, straight or branched chain C 1~6 Heteroalkyl, -C 1~4 Alkoxy, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, -C 1~6 Alkylamino, -CN, -OC(O)-C 1~6 Alkyl, -N(H)C(O)-C 1~6 Alkyl, -C(O)OC 1~6 Alkyl, -COOH, -C 1~6 AlkylC(O)OH, -C 1~6 Alkyl C(O)OC 1~6 Alkyl, NH2, -C 1~4 It is selected from alkylhydroxy, and halogen, such as F, Cl or Br, for example F or Cl.

[0397] In some embodiments of the compound of Formula V, R 1 is H and R 2 , R 3 , R 4 are, independently of each other, H, straight-chain or branched -C 1~6 Alkyl, -C 1~4It is selected from alkoxy, CF3, CHF2, CMeF2, OCF3, OCHF2, -CN, and halogen, such as F, Cl or Br, for example F or Cl.

[0398] In some embodiments of the compound of Formula V, L 1 is -CH2- and R 1 , R 2 , R 3 , and R 4 are, independently of each other, H, straight-chain or branched -C 1~6 Alkyl, straight or branched chain C 1~6 Heteroalkyl, -C 1~4 Alkoxy, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, -C 1~6 Alkylamino, -CN, -OC(O)-C 1~6 Alkyl, -N(H)C(O)-C 1~6 Alkyl, -C(O)OC 1~6 Alkyl, -COOH, -C 1~6 AlkylC(O)OH, -C 1~6 Alkyl C(O)OC 1~6 Alkyl, NH2, -C 1~4 It is selected from alkylhydroxy, and halogen, such as F, Cl or Br, for example F or Cl.

[0399] In some embodiments of the compound of Formula V, L 1 is -CH2- and R 1 , R 2 , R 3 , and R 4 are, independently of each other, H, straight-chain or branched -C 1~6 Alkyl, -C 1~4 It is selected from alkoxy, CF3, CHF2, CMeF2, OCF3, OCHF2, -CN, and halogen, such as F, Cl or Br, for example F or Cl.

[0400] In some embodiments of the compound of Formula V, L 1 is -CH(CH3)- and R 1 , R 2 , R 3, and R 4 are, independently of each other, H, straight-chain or branched -C 1~6 Alkyl, straight or branched chain C 1~6 Heteroalkyl, -C 1~4 Alkoxy, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, -C 1~6 Alkylamino, -CN, -OC(O)-C 1~6 Alkyl, -N(H)C(O)-C 1~6 Alkyl, -C(O)OC 1~6 Alkyl, -COOH, -C 1~6 AlkylC(O)OH, -C 1~6 Alkyl C(O)OC 1~6 Alkyl, NH2, -C 1~4 It is selected from alkylhydroxy, and halogen, such as F, Cl or Br, for example F or Cl.

[0401] In some embodiments of the compound of Formula V, L 1 is -CH(CH3)- and R 1 , R 2 , R 3 , and R 4 are, independently of each other, H, straight-chain or branched -C 1~6 Alkyl, -C 1~4 It is selected from alkoxy, CF3, CHF2, CMeF2, OCF3, OCHF2, -CN, and halogen, such as F, Cl or Br, for example F or Cl.

[0402] In some embodiments of the compound of Formula V, L 1 is -CH2- and R 1 is H and R 2 , R 3 , R 4 are, independently of each other, H, straight-chain or branched -C 1~6 Alkyl, straight or branched chain C 1~6 Heteroalkyl, -C 1~4 Alkoxy, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, -C 1~6 Alkylamino, -CN, -OC(O)-C 1~6Alkyl, -N(H)C(O)-C 1~6 Alkyl, -C(O)OC 1~6 Alkyl, -COOH, -C 1~6 AlkylC(O)OH, -C 1~6 Alkyl C(O)OC 1~6 Alkyl, NH2, -C 1~4 It is selected from alkylhydroxy, and halogen, such as F, Cl or Br, for example F or Cl.

[0403] In some embodiments of the compound of Formula V, L 1 is -CH2- and R 1 is H and R 2 , R 3 , R 4 are, independently of each other, H, straight-chain or branched -C 1~6 Alkyl, -C 1~4 It is selected from alkoxy, CF3, CHF2, CMeF2, OCF3, OCHF2, -CN, and halogen, such as F, Cl or Br, for example F or Cl.

[0404] In some embodiments of the compound of Formula V, L 1 is -CH(CH3)- and R 1 is H and R 2 , R 3 , R 4 are, independently of each other, H, straight-chain or branched -C 1~6 Alkyl, straight or branched chain C 1~6 Heteroalkyl, -C 1~4 Alkoxy, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, -C 1~6 Alkylamino, -CN, -OC(O)-C 1~6 Alkyl, -N(H)C(O)-C 1~6 Alkyl, -C(O)OC 1~6 Alkyl, -COOH, -C 1~6 AlkylC(O)OH, -C 1~6 Alkyl C(O)OC 1~6 Alkyl, NH2, -C 1~4It is selected from alkylhydroxy, and halogen, such as F, Cl or Br, for example F or Cl.

[0405] In some embodiments of the compound of Formula V, L 1 is -CH(CH3)- and R 1 is H and R 2 , R 3 , R 4 are, independently of each other, H, straight-chain or branched -C 1~6 Alkyl, -C 1~4 It is selected from alkoxy, CF3, CHF2, CMeF2, OCF3, OCHF2, -CN, and halogen, such as F, Cl or Br, for example F or Cl.

[0406] In some embodiments of the compound of Formula V, L 2 is a covalent bond and R 1 , R 2 , R 3 , and R 4 are, independently of each other, H, straight-chain or branched -C 1~6 Alkyl, straight or branched chain C 1~6 Heteroalkyl, -C 1~4 Alkoxy, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, -C 1~6 Alkylamino, -CN, -OC(O)-C 1~6 Alkyl, -N(H)C(O)-C 1~6 Alkyl, -C(O)OC 1~6 Alkyl, -COOH, -C 1~6 AlkylC(O)OH, -C 1~6 Alkyl C(O)OC 1~6 Alkyl, NH2, -C 1~4 It is selected from alkylhydroxy, and halogen, such as F, Cl or Br, for example F or Cl.

[0407] In some embodiments of the compound of Formula V, L 2 is a covalent bond and R 1 , R 2 , R 3 , and R 4are, independently of each other, H, straight-chain or branched -C 1~6 Alkyl, -C 1~4 It is selected from alkoxy, CF3, CHF2, CMeF2, OCF3, OCHF2, -CN, and halogen, such as F, Cl or Br, for example F or Cl.

[0408] In some embodiments of the compound of Formula V, L 2 is a covalent bond and R 1 is H and R 2 , R 3 , R 4 are, independently of each other, H, straight-chain or branched -C 1~6 Alkyl, straight or branched chain C 1~6 Heteroalkyl, -C 1~4 Alkoxy, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, -C 1~6 Alkylamino, -CN, -OC(O)-C 1~6 Alkyl, -N(H)C(O)-C 1~6 Alkyl, -C(O)OC 1~6 Alkyl, -COOH, -C 1~6 AlkylC(O)OH, -C 1~6 Alkyl C(O)OC 1~6 Alkyl, NH2, -C 1~4 It is selected from alkylhydroxy, and halogen, such as F, Cl or Br, for example F or Cl.

[0409] In some embodiments of the compound of Formula V, L 2 is a covalent bond and R 1 is H and R 2 , R 3 , R 4 are, independently of each other, H, straight-chain or branched -C 1~6 Alkyl, -C 1~4 It is selected from alkoxy, CF3, CHF2, CMeF2, OCF3, OCHF2, -CN, and halogen, such as F, Cl or Br, for example F or Cl.

[0410] In some embodiments of the compound of Formula V, L 2is -CH2- and R 1 , R 2 , R 3 , and R 4 are, independently of each other, H, straight-chain or branched -C 1~6 Alkyl, straight or branched chain C 1~6 Heteroalkyl, -C 1~4 Alkoxy, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, -C 1~6 Alkylamino, -CN, -OC(O)-C 1~6 Alkyl, -N(H)C(O)-C 1~6 Alkyl, -C(O)OC 1~6 Alkyl, -COOH, -C 1~6 AlkylC(O)OH, -C 1~6 Alkyl C(O)OC 1~6 Alkyl, NH2, -C 1~4 It is selected from alkylhydroxy, and halogen, such as F, Cl or Br, for example F or Cl.

[0411] In some embodiments of the compound of Formula V, L 2 is -CH2- and R 1 , R 2 , R 3 , and R 4 are, independently of each other, H, straight-chain or branched -C 1~6 Alkyl, -C 1~4 It is selected from alkoxy, CF3, CHF2, CMeF2, OCF3, OCHF2, -CN, and halogen, such as F, Cl or Br, for example F or Cl.

[0412] In some embodiments of the compound of Formula V, L 2 is -CH(CH3)- and R 1 , R 2 , R 3 , and R 4 are, independently of each other, H, straight-chain or branched -C 1~6 Alkyl, straight or branched chain C 1~6 Heteroalkyl, -C 1~4Alkoxy, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, -C 1~6 Alkylamino, -CN, -OC(O)-C 1~6 Alkyl, -N(H)C(O)-C 1~6 Alkyl, -C(O)OC 1~6 Alkyl, -COOH, -C 1~6 AlkylC(O)OH, -C 1~6 Alkyl C(O)OC 1~6 Alkyl, NH2, -C 1~4 It is selected from alkylhydroxy, and halogen, such as F, Cl or Br, for example F or Cl.

[0413] In some embodiments of the compound of Formula V, L 2 is -CH(CH3)- and R 1 , R 2 , R 3 , and R 4 are, independently of each other, H, straight-chain or branched -C 1~6 Alkyl, -C 1~4 It is selected from alkoxy, CF3, CHF2, CMeF2, OCF3, OCHF2, -CN, and halogen, such as F, Cl or Br, for example F or Cl.

[0414] In some embodiments of the compound of Formula V, L 2 is -CH2- and R 1 is H and R 2 , R 3 , R 4 are, independently of each other, H, straight-chain or branched -C 1~6 Alkyl, straight or branched chain C 1~6 Heteroalkyl, -C 1~4 Alkoxy, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, -C 1~6 Alkylamino, -CN, -OC(O)-C 1~6 Alkyl, -N(H)C(O)-C 1~6 Alkyl, -C(O)OC 1~6 Alkyl, -COOH, -C 1~6 AlkylC(O)OH, -C1~6 Alkyl C(O)OC 1~6 Alkyl, NH2, -C 1~4 It is selected from alkylhydroxy, and halogen, such as F, Cl or Br, for example F or Cl.

[0415] In some embodiments of the compound of Formula V, L 2 is -CH2- and R 1 is H and R 2 , R 3 , R 4 are, independently of each other, H, straight-chain or branched -C 1~6 Alkyl, -C 1~4 It is selected from alkoxy, CF3, CHF2, CMeF2, OCF3, OCHF2, -CN, and halogen, such as F, Cl or Br, for example F or Cl.

[0416] In some embodiments of the compound of Formula V, L 2 is -CH(CH3)- and R c is H and R 1 is H and R 2 , R 3 , R 4 are, independently of each other, H, straight-chain or branched -C 1~6 Alkyl, straight or branched chain C 1~6 Heteroalkyl, -C 1~4 Alkoxy, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, -C 1~6 Alkylamino, -CN, -OC(O)-C 1~6 Alkyl, -N(H)C(O)-C 1~6 Alkyl, -C(O)OC 1~6 Alkyl, -COOH, -C 1~6 AlkylC(O)OH, -C 1~6 Alkyl C(O)OC 1~6 Alkyl, NH2, -C 1~4 It is selected from alkylhydroxy, and halogen, such as F, Cl or Br, for example F or Cl.

[0417] In some embodiments of the compound of Formula V, L2 is -CH(CH3)- and R c is H and R 1 is H and R 2 , R 3 , R 4 are, independently of each other, H, straight-chain or branched -C 1~6 Alkyl, -C 1~4 It is selected from alkoxy, CF3, CHF2, CMeF2, OCF3, OCHF2, -CN, and halogen, such as F, Cl or Br, for example F or Cl.

[0418] In some embodiments of the compound of Formula V, R 1 , R 2 , R 3 , and R 4 One of the formulas is -L 3 -X 2 where L 3 is a covalent bond, and X 2 is C 3~6 cycloalkyl, C6 aryl, 5- to 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~6 Alkyl, -C 1~4 Alkoxy, NH2, NMe2, halogen, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, and -C 1~4 It is substituted with one or more of alkylhydroxy.

[0419] In some embodiments of the compound of Formula V, R 1 , R 2 , R 3 , and R 4 One of the formulas is -L 3 -X 2 where L 3 is a covalent bond, and X 2 is C 3~6 cycloalkyl, C6 aryl, 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C1~4 Substituted with one or more of alkoxy, NH2, NMe2, and halogen (eg, F).

[0420] In some embodiments of the compound of Formula V, R 1 , R 2 , R 3 , and R 4 One of the formulas is -L 3 -X 2 where L 3 is a covalent bond, and X 2 is cyclopropyl, cyclobutyl, azetidinyl, oxetanyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl, C6 aryl, pyridinyl, wherein X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, e.g., methyl, -C 1~4 Substituted with one or more of alkoxy, eg, -OMe, NMe2, and halogen, eg, F.

[0421] In some embodiments of the compound of Formula V, R 1 , R 2 , R 3 , and R 4 One of the formulas is -L 3 -X 2 where L 3 is a covalent bond, and X 2is cyclopropyl, methyl-cyclopropyl, fluoro-cyclopropyl, difluoro-cyclopropyl, cyclobutyl, C6 aryl, methyl-C6 aryl, fluoro-C6 aryl, methoxy-C6 aryl, pyridinyl, pyrrolidinyl, N-methyl-pyrrolidinyl, methyl-pyrrolidinyl, piperidinyl, N-methylpiperidinyl, methyl-piperidinyl, difluoro-piperidinyl, morpholinyl, N-methyl-morpholinyl, oxetanyl, methyl-oxetanyl, piperazinyl, N-methyl-piperazinyl, azetidinyl, methyl-azetidinyl, N-dimethyl-azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl.

[0422] In some embodiments of the compound of Formula V, R 1 , R 2 , R 3 , and R 4 One of the formulas is -L 3 -X 2 where L 3 is a covalent bond, and X 2 is H, cyclopropyl, methyl-cyclopropyl, fluoro-cyclopropyl, difluoro-cyclopropyl, cyclobutyl, azetidinyl, NMe2-azetidinyl, oxetanyl, methyl-oxetanyl, pyrrolidinyl, methyl-pyrrolidinyl, piperidinyl, Me-piperidinyl, di-F-piperidinyl, N-Me-piperazinyl, morpholinyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl, C6 aryl, methoxy-C6 aryl, pyridinyl.

[0423] In some embodiments of the compound of Formula V, R 1 , R 2 , R 3 , and R 4 One of the formulas is -L 3 -X 2 where L 3 is a straight or branched chain C 1~4 is alkyl (such as -CH2-), and X 2 is C3~6 cycloalkyl, C6 aryl, 5- to 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~6 Alkyl, -C 1~4 Alkoxy, NH2, NMe2, halogen, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, and -C 1~4 It is substituted with one or more of alkylhydroxy.

[0424] In some embodiments of the compound of Formula V, R 1 , R 2 , R 3 , and R 4 One of the -L 3 -X 2 is a group of L 3 is a straight or branched chain C 1~4 is alkyl (such as -CH2-), and X 2 is C 3~6 cycloalkyl, C6 aryl, 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2, and halogen (eg, F).

[0425] In some embodiments of the compound of Formula V, R 1 , R 2 , R 3 , and R 4 One of the formulas is -L 3 -X 2 is a group of L 3 is a linear or branched chain C 1~4 is alkyl (such as -CH2-), and X 2is cyclopropyl, cyclobutyl, C6 aryl, pyridinyl, pyrrolidinyl, piperidinyl, morpholinyl, oxetanyl, piperazinyl, azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl, wherein X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2 and halogen.

[0426] In some embodiments of the compound of Formula V, R 1 , R 2 , R 3 , and R 4 One of the formulas is -L 3 -X 2 where L 3 is a straight or branched chain C 1~4 is alkyl (such as -CH2-), and X 2 is cyclopropyl, methyl-cyclopropyl, fluoro-cyclopropyl, difluoro-cyclopropyl, cyclobutyl, C6 aryl, methyl-C6 aryl, fluoro-C6 aryl, methoxy-C6 aryl, pyridinyl, pyrrolidinyl, N-methyl-pyrrolidinyl, methyl-pyrrolidinyl, piperidinyl, N-methylpiperidinyl, methyl-piperidinyl, difluoro-piperidinyl, morpholinyl, N-methyl-morpholinyl, oxetanyl, methyl-oxetanyl, piperazinyl, N-methyl-piperazinyl, azetidinyl, methyl-azetidinyl, N-dimethyl-azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl.

[0427] In some embodiments of the compound of Formula V, R 1 , R 2 , R 3 , and R 4 One of the formulas is -L 3 -X 2 where L 3is a linear or branched chain C 1~4 is alkyl (such as -CH2-), and X 2 is morpholinyl, N-methyl-morpholinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl.

[0428] In some embodiments of the compound of Formula V, R 1 , R 2 , R 3 , and R 4 One of the formulas is -L 3 -X 2 where L 3 is -O- and X 2 is C 3~6 cycloalkyl, C6 aryl, 5- to 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~6 Alkyl, -C 1~4 Alkoxy, NH2, NMe2, halogen, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, and -C 1~4 It is substituted with one or more of alkylhydroxy.

[0429] In some embodiments of the compound of Formula V, R 1 , R 2 , R 3 , and R 4 One of the formulas is -L 3 -X 2 where L 3 is -O- and X 2 is C 3~6 cycloalkyl, C6 aryl, 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2, and halogen (eg, F).

[0430] In some embodiments of the compound of Formula V, R 1 , R 2 , R 3 , and R 4 One of the formulas is -L 3 -X 2 is a group of L 3 is -O- and X 2 is cyclopropyl, cyclobutyl, C6 aryl, pyridinyl, pyrrolidinyl, piperidinyl, morpholinyl, oxetanyl, piperazinyl, azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl, wherein X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2 and halogen.

[0431] In some embodiments of the compound of Formula V, R 1 , R 2 , R 3 , and R 4 One of the formulas is -L 3 -X 2 where L 3 is -O- and X 2 is cyclopropyl, methyl-cyclopropyl, fluoro-cyclopropyl, difluoro-cyclopropyl, cyclobutyl, C6 aryl, methyl-C6 aryl, fluoro-C6 aryl, methoxy-C6 aryl, pyridinyl, pyrrolidinyl, N-methyl-pyrrolidinyl, methyl-pyrrolidinyl, piperidinyl, N-methylpiperidinyl, methyl-piperidinyl, difluoro-piperidinyl, morpholinyl, N-methyl-morpholinyl, oxetanyl, methyl-oxetanyl, piperazinyl, N-methyl-piperazinyl, azetidinyl, methyl-azetidinyl, N-dimethyl-azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl.

[0432] In some embodiments of the compound of Formula V, R1 , R 2 , R 3 , and R 4 Any one of the formula -L 3 -X 2 where L 3 is -O- and X 2 is cyclopropyl, pyrrolidinyl, N-methyl-pyrrolidinyl.

[0433] In some embodiments of the compound of Formula V, R 1 , R 2 , R 3 , and R 4 One of the formulas is -L 3 -X 2 where L 3 is -O-CH2-, and X 2 is C 3~6 cycloalkyl, C6 aryl, 5- to 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~6 Alkyl, -C 1~4 Alkoxy, NH2, NMe2, halogen, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, and -C 1~4 It is substituted with one or more of alkylhydroxy.

[0434] In some embodiments of the compound of Formula V, R 1 , R 2 , R 3 , and R 4 One of the formulas is -L 3 -X 2 where L 3 is -O-CH2-, and X 2 is C 3~6 cycloalkyl, C6 aryl, 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4Substituted with one or more of alkoxy, NH2, NMe2, and halogen (eg, F).

[0435] In some embodiments of the compound of Formula V, R 1 , R 2 , R 3 , and R 4 One of the formulas is -L 3 -X 2 is a group of L 3 is -O-CH2-, and X 2 is cyclopropyl, cyclobutyl, C6 aryl, pyridinyl, pyrrolidinyl, piperidinyl, morpholinyl, oxetanyl, piperazinyl, azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl, wherein X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2 and halogen.

[0436] In some embodiments of the compound of Formula V, R 1 , R 2 , R 3 , and R 4 One of the formulas is -L 3 -X 2 where L 3 is -O-CH2-, and X 2is cyclopropyl, methyl-cyclopropyl, fluoro-cyclopropyl, difluoro-cyclopropyl, cyclobutyl, C6 aryl, methyl-C6 aryl, fluoro-C6 aryl, methoxy-C6 aryl, pyridinyl, pyrrolidinyl, N-methyl-pyrrolidinyl, methyl-pyrrolidinyl, piperidinyl, N-methylpiperidinyl, methyl-piperidinyl, difluoro-piperidinyl, morpholinyl, N-methyl-morpholinyl, oxetanyl, methyl-oxetanyl, piperazinyl, N-methyl-piperazinyl, azetidinyl, methyl-azetidinyl, N-dimethyl-azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl.

[0437] In some embodiments of the compound of Formula V, R 1 , R 2 , R 3 , and R 4 Any one of the formula -L 3 -X 2 where L 3 is -O-CH2-, and X 2 is pyrrolidinyl, N-methyl-pyrrolidinyl.

[0438] In some embodiments of the compound of Formula V, R 1 , R 2 , R 3 , and R 4 One of the formulas is -L 3 -X 2 where L 3 is -O-CH2-CH2- and X 2 is C 3~6 cycloalkyl, C6 aryl, 5- to 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~6 Alkyl, -C 1~4 Alkoxy, NH2, NMe2, halogen, CF3, CHF2, CMeF2, -O-(CH2)2-OMe, OCF3, OCHF2, and -C 1~4It is substituted with one or more of alkylhydroxy.

[0439] In some embodiments of the compound of Formula V, R 1 , R 2 , R 3 , and R 4 One of the formulas is -L 3 -X 2 where L 3 is -O-CH2-CH2- and X 2 is C 3~6 cycloalkyl, C6 aryl, 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl, and X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2, and halogen (eg, F).

[0440] In some embodiments of the compound of Formula V, R 1 , R 2 , R 3 , and R 4 One of the formulas is -L 3 -X 2 is a group of L 3 is -O-CH2-CH2- and X 2 is cyclopropyl, cyclobutyl, C6 aryl, pyridinyl, pyrrolidinyl, piperidinyl, morpholinyl, oxetanyl, piperazinyl, azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl, wherein X 2 is unsubstituted or a straight or branched chain C 1~4 Alkyl, -C 1~4 Substituted with one or more of alkoxy, NH2, NMe2 and halogen.

[0441] In some embodiments of the compound of Formula V, R 1 , R 2 , R 3 , and R 4 One of the formulas is -L3 -X 2 where L 3 is -O-CH2-CH2- and X 2 is cyclopropyl, methyl-cyclopropyl, fluoro-cyclopropyl, difluoro-cyclopropyl, cyclobutyl, C6 aryl, methyl-C6 aryl, fluoro-C6 aryl, methoxy-C6 aryl, pyridinyl, pyrrolidinyl, N-methyl-pyrrolidinyl, methyl-pyrrolidinyl, piperidinyl, N-methylpiperidinyl, methyl-piperidinyl, difluoro-piperidinyl, morpholinyl, N-methyl-morpholinyl, oxetanyl, methyl-oxetanyl, piperazinyl, N-methyl-piperazinyl, azetidinyl, methyl-azetidinyl, N-dimethyl-azetidinyl, 2-oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-azabicyclo[3.2.1]octan-3-yl.

[0442] In some embodiments of the compound of Formula V, R 1 , R 2 , R 3 , and R 4 Any one of the formula -L 3 -X 2 where L 3 is -O-CH2-CH2- and X 2 is morpholinyl.

[0443] In some embodiments, the compound of Formula I is a compound of Formula Va or a pharmaceutically acceptable salt or stereoisomer thereof: [ka] During the ceremony, w 1 , w 2 , w 3 , w 4 , w 5 one or two of which are independently selected from C, N, S, and O, and the remaining w 1 , w 2 , w 3 , w 4 , w 5is C, R 1 ,...

Claims

1. A compound of formula I, or a pharma- ceutically acceptable salt or stereoisomer thereof, 【Chemistry 57】 During the ceremony, X １ is a linear or branched chain C １～６ Alkyl, C ３～８ Cycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, 4- to 8-membered heterocycloalkyl; X １ is unsubstituted or halogen, linear or branched C １～６ Alkyl, linear or branched C １～６ Heteroalkyl, CF ３ , C.H.F. ２ , CMeF ２ , -O-CHF ２ , —O—(CH ２ ) ２ - OMe, OCF ３ , C １～６ Alkylamino, -CN, -N(H)C(O)-C １～６ Alkyl, -OC(O)-C １～６ Alkyl, -OC(O)-C １～４ Alkylamino, -C(O)O-C １～６ Alkyl, -COOH, -C １～６ AlkylC(O)OH, -C １～６ Alkyl C(O)O-C １～６ Alkyl, NH ２ , C １～４ Alkoxy, C １～４ Alkylhydroxy, -CH ２ F, -N(H)C(O)-OC １～６ Alkyl, and C(OH)(CF ３ ) or Or X １ together with the N atom of the carbamate form a 4-8 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C １～６ Alkyl, CF ３ , C.H.F. ２ , CMeF ２ , —O—(CH ２ ) ２ - OMe, OCF ３ , O.C.H.F. ２ , C １～６ Alkylamino, -CN, -N(H)C(O)-C １～６ Alkyl, -OC(O)-C １～６ Alkyl, —C(O)O—C １～６ Alkyl, -COOH, -C １～６ AlkylC(O)OH, -C １～６ Alkyl C(O)O-C １～６ Alkyl, NH ２ , C １～４ Alkylhydroxy, and C １～４ alkoxy; X ２ is H, C ３～６ Cycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, 4- to 8-membered heterocycloalkyl; X ２ is unsubstituted or a straight or branched chain C １～６ Alkyl, -C １～４ Alkoxy, NH ２ , NMe ２ , halogen, CF ３ , C.H.F. ２ , CMeF ２ , —O—(CH ２ ) ２ - OMe, OCF ３ , O.C.H.F. ２ , and C １～４ substituted with one or more of alkylhydroxy; L １ is a covalent bond, linear or branched C １～６ is alkyl, L ２ is a covalent bond, linear or branched C １～６ is alkyl, L ３ is a covalent bond, linear or branched C １～６ Alkyl, -O-, or -C １～４ Alkoxy, linear or branched C １～６ The compound, or a pharma- ceutically acceptable salt or stereoisomer thereof, wherein alkyl is unsubstituted or substituted with one or more halogens.

2. In the formula, X １ is a linear or branched -C １～６ Alkyl, -C ３～６ Cycloalkyl, -C ６～１０ aryl, 5- to 10-membered heteroaryl, 5- to 6-membered heterocycloalkyl, １ is unsubstituted or is a halogen, a straight or branched chain -C １～４ Alkyl, CF ３ , C.H.F. ２ , CMeF ２ , —O—(CH ２ ) ２ - OMe, OCF ３ , O.C.H.F. ２ , C １～６ Alkylamino, -CN, NH ２ , C １～４ Alkylhydroxy, and C １～４ or substituted with one or more of X １ together with the N atom of the carbamate form a 5-6 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C １～４ Alkyl, CF ３ , C.H.F. ２ , CMeF ２ , —O—(CH ２ ) ２ - OMe, OCF ３ , O.C.H.F. ２ , C １～６ Alkylamino, -CN, NH ２ , C １～４ Alkylhydroxy, and C １～４ 2. The compound of claim 1, or a pharma- ceutically acceptable salt or stereoisomer thereof, substituted with one or more of alkoxy.

3. In the formula, X ２ But, H, C ３～６ Cycloalkyl, C ６ aryl, 5- to 6-membered heteroaryl, 4- to 8-membered heterocycloalkyl; X ２ is unsubstituted or a straight or branched chain C １～４ Alkyl, -C １～４ Alkoxy, NH ２ , NMe ２ , halogen, CF ３ , C.H.F. ２ , CMeF ２ , —O—(CH ２ ) ２ - OMe, OCF ３ , O.C.H.F. ２ , and -C １～４ 2. The compound of claim 1, or a pharma- ceutically acceptable salt or stereoisomer thereof, substituted with one or more of alkylhydroxy.

4. In the formula, L １ But -CH ２ - or -CH(CH ３ )- and / or L ２ is a covalent bond, -CH ２ - or -CH(CH ３ )- and / or L ３ But -CH ２ --, --O-, --CH ２ -O-, -CH ２ -CH ２ 2. The compound of claim 1, or a pharma- ceutically acceptable salt or stereoisomer thereof, wherein:

5. 1. A compound according to claim 1 of formula II, or a pharma- ceutically acceptable salt or stereoisomer thereof, 【Chemistry 58】 During the ceremony, X １ is a linear or branched chain C １～６ Alkyl, C ３～６ Cycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, 4- to 8-membered heterocycloalkyl; X １ is unsubstituted or substituted with halogen, linear or branched C １～６ Alkyl, linear or branched C １～６ Heteroalkyl, CF ３ , C.H.F. ２ , CMeF ２ , -O-CHF ２ , —O—(CH ２ ) ２ - OMe, OCF ３ , C １～６ Alkylamino, -CN, -N(H)C(O)-C １～６ Alkyl, -OC(O)-C １～６ Alkyl, -OC(O)-C １～４ Alkylamino, -C(O)O-C １～６ Alkyl, -COOH, -C １～６ AlkylC(O)OH, -C １～６ Alkyl C(O)O-C １～６ Alkyl, NH ２ , C １～４ Alkoxy, and C １～４ substituted with one or more of alkylhydroxy; Or X １ together with the N atom of the carbamate form a 4-8 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C １～６ Alkyl, CF ３ , C.H.F. ２ , CMeF ２ , —O—(CH ２ ) ２ - OMe, OCF ３ , O.C.H.F. ２ , C １～６ Alkylamino, -CN, -N(H)C(O)-C １～６ Alkyl, -OC(O)-C １～６ Alkyl, —C(O)O—C １～６ Alkyl, -COOH, -C １～６ AlkylC(O)OH, -C １～６ Alkyl C(O)O-C １～６ Alkyl, NH ２ , C １～４ Alkylhydroxy, and C １～４ alkoxy; X ２ is H, C ３～６ Cycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, 4- to 8-membered heterocycloalkyl; X ２ is unsubstituted or a straight or branched chain C １～６ Alkyl, -C １～４ Alkoxy, NH ２ , NMe ２ , halogen, CF ３ , C.H.F. ２ , CMeF ２ , —O—(CH ２ ) ２ - OMe, OCF ３ , O.C.H.F. ２ , and C １～４ substituted with one or more of alkylhydroxy; L ２ is a covalent bond, linear or branched C １～６ is alkyl, L ３ is a covalent bond, linear or branched C １～６ Alkyl, —O—, —C １～４ is an alkoxy; R ａ is H or a straight or branched chain C １～４ is alkyl (such as methyl or ethyl), The compound, or a pharma- ceutically acceptable salt or stereoisomer thereof, wherein n is 1 or 2.

6. In the formula, n is 1 and R ａ 6. The compound of claim 5, or a pharma- ceutically acceptable salt or stereoisomer thereof, wherein is H or methyl.

7. 6. The compound of claim 5, or a pharma- ceutically acceptable salt or stereoisomer thereof, wherein p is 0.

8. In the formula, p is 1 and R ｂ , R ｃ is H or p is 1 and R ｂ is methyl, R ｃ is H, or a pharma- ceutically acceptable salt or stereoisomer thereof.

9. In the formula, L ２ is a covalent bond, -CH ２ - or -CH(CH ３ )- and / or L ３ But -CH ２ --, --O-, --CH ２ -O-, -CH ２ -CH ２ 6. The compound of claim 5, or a pharma- ceutically acceptable salt or stereoisomer thereof, wherein:

10. 10. A compound according to claim 1 of formula III (such as IVa or IVb), or a pharma- ceutically acceptable salt or stereoisomer thereof, 【Chemistry 59】 During the ceremony, X １ is a linear or branched chain C １～６ Alkyl, C ３～６ Cycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, 4- to 8-membered heterocycloalkyl; X １ is unsubstituted or substituted with halogen, linear or branched C １～６ Alkyl, linear or branched C １～６ Heteroalkyl, CF ３ , C.H.F. ２ , CMeF ２ , -O-CHF ２ , —O—(CH ２ ) ２ - OMe, OCF ３ , C １～６ Alkylamino, -CN, -N(H)C(O)-C １～６ Alkyl, -OC(O)-C １～６ Alkyl, -OC(O)-C １～４ Alkylamino, -C(O)O-C １～６ Alkyl, -COOH, -C １～６ AlkylC(O)OH, -C １～６ Alkyl C(O)O-C １～６ Alkyl, NH ２ , C １～４ Alkoxy, and C １～４ substituted with one or more of alkylhydroxy; Or X １ together with the N atom of the carbamate form a 4-8 membered heterocycloalkyl, which is unsubstituted or substituted with halogen, straight or branched chain -C １～６ Alkyl, CF ３ , C.H.F. ２ , CMeF ２ , —O—(CH ２ ) ２ - OMe, OCF ３ , O.C.H.F. ２ , C １～６ Alkylamino, -CN, -N(H)C(O)-C １～６ Alkyl, -OC(O)-C １～６ Alkyl, —C(O)O—C １～６ Alkyl, -COOH, -C １～６ AlkylC(O)OH, -C １～６ Alkyl C(O)O-C １～６ Alkyl, NH ２ , C １～４ Alkylhydroxy, and C １～４ alkoxy; X ２ is H, C ３～６ Cycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, 4- to 8-membered heterocycloalkyl; X ２ is unsubstituted or a straight or branched chain C １～６ Alkyl, -C １～４ Alkoxy, NH ２ , NMe ２ , halogen, CF ３ , C.H.F. ２ , CMeF ２ , —O—(CH ２ ) ２ - OMe, OCF ３ , O.C.H.F. ２ , and C １～４ substituted with one or more of alkylhydroxy; L ３ is a covalent bond, linear or branched C １～６ Alkyl, —O—, —C １～４ is an alkoxy; R ａ , R ｂ , R ｃ are each independently H, linear or branched C １～４ is alkyl (e.g., methyl), The compound, or a pharma- ceutically acceptable salt or stereoisomer thereof, wherein p is 0 or 1.

11. 11. The compound of claim 10, or a pharma- ceutically acceptable salt or stereoisomer thereof, wherein p is 0.

12. In the formula, p is 1 and R ｂ , R ｃ is H or p is 1 and R ｂ is methyl, R ｃ is H, or a pharma- ceutically acceptable salt or stereoisomer thereof.

13. 10. A compound according to claim 1 of formula V, VI or VII, or a pharma- ceutically acceptable salt or stereoisomer thereof, 【Chemistry 60】 【Chemistry 61】 【Chemistry 62】 During the ceremony, W １ , W ２ , W ３ , W ４ , W ５ one or two of are independently selected from C, N, S, and O, and the remaining w １ , W ２ , W ３ , W ４ , W ５ is C, W ６ , W ７ , W ８ , W ９ One or two of the w are selected from C and O, and the remaining w ６ , W ７ , W ８ , W ９ is C, W １０ , W １１ are independently selected from C and N; L １ is a covalent bond, linear or branched C １～６ is alkyl, L ２ is a covalent bond, linear or branched C １～６ is alkyl, R １ , R ２ , R ３ , R ４ are each independently H, a straight or branched chain -C １～６ Alkyl, linear or branched C １～６ Heteroalkyl, -C １～４ Alkoxy, CF ３ , C.H.F. ２ , CMeF ２ , —O—(CH ２ ) ２ - OMe, OCF ３ , O.C.H.F. ２ , -C １～６ Alkylamino, -CN, -OC(O)-C １～６ Alkyl, -N(H)C(O)-C １～６ Alkyl, —C(O)O—C １～６ Alkyl, -COOH, -C １～６ AlkylC(O)OH, -C １～６ Alkyl C(O)O-C １～６ Alkyl, NH ２ , -C １～４ alkylhydroxy and halogen such as F, Cl or Br, for example F or Cl, or a group of the formula -L ３ -X ２ wherein L ３ is a covalent bond, linear or branched C １～６ Alkyl, —O—, —C １～４ Alkoxy, X ２ is C ３～６ Cycloalkyl, C ６～１０ aryl, 5- to 10-membered heteroaryl, 4- to 8-membered heterocycloalkyl; X ２ is unsubstituted or a straight or branched chain C １～６ Alkyl, -C １～４ Alkoxy, NH ２ , NMe ２ , halogen, CF ３ , C.H.F. ２ , CMeF ２ , —O—(CH ２ ) ２ - OMe, OCF ３ , O.C.H.F. ２ , and -C １～４ substituted with one or more alkylhydroxy groups; R ５ , R ６ , R ７ R ８ are each independently H, linear or branched C １～４ selected from alkyl, such as methyl, and halogen, such as F or Cl, such as F; Z is a linear or branched -C １～６ Alkyl, -C ３～６ cycloalkyl, 4- to 8-membered heterocycloalkyl, Z is unsubstituted or C １～４ Alkyl, C ６ Aryl, C ６ Aryloxy, 6-membered heteroaryl or CF ３ or Z, together with the N atom of the carbamate, is unsubstituted, or C １～４ Alkyl, C ６ Aryl, C ６ Aryloxy, 6-membered heteroaryl or CF ３ forming a 4-8 membered heterocycloalkyl substituted with The compound, or a pharma- ceutically acceptable salt or stereoisomer thereof, wherein q is 0 or 1.

14. 1. A compound according to claim 1 of formula VIII or VIIIa, or a pharma- ceutically acceptable salt or stereoisomer thereof, 【Chemistry 63】 In the formula, R ａ is H or methyl, W １ and W ２ is selected from the following compounds, or a pharma- ceutically acceptable salt or stereoisomer thereof: 【Chemistry 64】 【Chemistry 65】 【Chemistry 66】 【Chemistry 67】 【Chemistry 68】 【Chemistry 69】 【Chemistry 70】

15. The group consisting of 【Table 6-1】 【Table 6-2】 【Table 6-3】 【Table 6-4】 【Table 6-5】 【Table 6-6】 【Table 6-7】 【Table 6-8】 【Table 6-9】 【Table 6-10】 【Table 6-11】 【Table 6-12】 【Table 6-13】 【Table 6-14】 【Table 6-15】 【Table 6-16】 【Table 6-17】 【Table 6-18】 【Table 6-19】 and pharma- ceutically acceptable salts and stereoisomers thereof.

16. The compound 【Chemistry 101】 16. The compound of claim 15, wherein:

17. 10. A composition comprising the compound of claim 1 or a pharma- ceutically acceptable salt or stereoisomer thereof.

18. 18. The composition of claim 17, further comprising a pharma- ceutically acceptable carrier and / or a second therapeutically active agent.

19. 13. A composition for treating cancer in a subject, particularly lung cancer, breast cancer and neuroendocrine cancer, comprising a compound according to claim 1 or a pharma- ceutically acceptable salt or stereoisomer thereof.

20. 13. A composition for treating Myc-driven cancer in a subject in need of treatment, comprising the compound of claim 1 or a pharma- ceutically acceptable salt or stereoisomer thereof.

21. The composition of claim 20 , wherein the Myc-driven cancer is a Myc-driven lung cancer.

22. The composition of claim 20 , wherein the Myc-driven cancer is Myc-driven small cell lung cancer.

23. The composition of claim 22, wherein the Myc-driven small cell lung cancer is L-Myc-high small cell lung cancer.

24. The composition of claim 20 , wherein the Myc-driven cancer is a Myc-driven non-small cell lung cancer.

25. The composition of claim 24, wherein the Myc-driven non-small cell lung cancer is N-Myc high non-small cell lung cancer.

26. 21. The composition of claim 20, wherein the composition is administered to the subject by oral administration.

27. A composition for degrading GSPT1 in a subject suffering from cancer, comprising the compound of claim 1 or a pharma- ceutically acceptable salt or stereoisomer thereof.

28. 28. The composition of claim 27, wherein the cancer is a Myc-driven cancer.

29. 29. The composition of claim 28, wherein the Myc-driven cancer is a Myc-driven lung cancer.

30. 29. The composition of claim 28, wherein the Myc-driven cancer is Myc-driven small cell lung cancer.

31. The composition of claim 30, wherein the Myc-driven small cell lung cancer is L-Myc-high small cell lung cancer.

32. The composition of claim 27, wherein the Myc-driven cancer is a Myc-driven non-small cell lung cancer.

33. The composition of claim 32, wherein the Myc-driven non-small cell lung cancer is N-Myc high non-small cell lung cancer.

34. 28. The composition of claim 27, wherein the composition is administered to the subject by oral administration.

35. 13. A composition for reducing GSPT1 levels in a subject suffering from cancer, comprising a compound according to claim 1 or a pharma- ceutically acceptable salt or stereoisomer thereof.

36. The composition of claim 35, wherein the cancer is a Myc-driven cancer.

37. The composition of claim 36, wherein the Myc-driven cancer is a Myc-driven lung cancer.

38. The composition of claim 36, wherein the Myc-driven cancer is a Myc-driven small cell lung cancer.

39. The composition of claim 38, wherein the Myc-driven small cell lung cancer is L-Myc high small cell lung cancer.

40. The composition of claim 36, wherein the Myc-driven cancer is a Myc-driven non-small cell lung cancer.

41. The composition of claim 40, wherein the Myc-driven non-small cell lung cancer is N-Myc high non-small cell lung cancer.

42. 36. The composition of claim 35, wherein the composition is administered to the subject by oral administration.

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