Pesticidal Active Cyclic Amine Compounds

Abstract

Compounds of formula (I) [Formula 1] TIFF2024512694000114.tif36153, wherein the substituents are as defined in claim 1. and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of these compounds may be used as pesticides.

Description

[Technical Field]

[0001] The present invention relates to pesticidally active, in particular insecticidally active, cyclic amines, preferably azetidinyl-, pyrrolidinyl-, piperidinyl- and piperazinyl-pyridinylcarbonyl compounds, processes for their preparation, compositions containing these compounds, and their use for controlling animal pests, including arthropods, in particular insects or representatives of the order Acarina. [Background technology]

[0002] WO 2015032280, CN106316931, WO 2017195703, WO 2019039429, WO 2019082808, JP 2019077618, JP 2019085371, and WO 2021053161 describe certain azetidinyl-, pyrrolidinyl-, piperidinyl-, or piperazinyl-pyridinylcarbonyl compounds for use in controlling plant-damaging pests. Summary of the Invention [Problem to be solved by the invention]

[0003] Novel pesticidally active azetidinyl-, pyrrolidinyl-, piperidinyl- and piperazinyl-pyridinylcarbonyl compounds have now been found. [Means for solving the problem]

[0004] The present invention therefore provides in a first aspect a compound of formula (I) [ka] (In the formula, R 1 is CN or C(=S)NH2; R 2 is H, OH, halogen, C1-C6-alkoxy or C1-C6-haloalkoxy; R3 is C1-C6-alkoxy-C1-C6-alkyl, C1-C6-haloalkoxy-C1-C6-alkyl, C2-C6-alkenyloxy-C1-C6-alkyl, C2-C6-haloalkenyloxy-C1-C6-alkyl, C2-C6-alkynyloxy-C1-C6-alkyl, C2-C6-haloalkynyloxy-C1-C6-alkyl, C3-C6-cycloalkoxy-C1-C6-alkyl, C3-C6-halocycloalkoxy-C1-C6-alkyl, C1-C6-alkylsulfonyl-C1-C6-alkyl; C1-C6-alkylsulfonyl-C3-C6-cycloalkyl, C1-C6-cyanoalkyl or C3-C6-cyanocycloalkyl; R 4 is C1-C6-haloalkyl, C2-C6-alkenyl, C2-C6-haloalkenyl, C3-C6-cycloalkyl, C3-C6-halocycloalkyl, phenyl, 1 to 3 independently selected substituents R 5 phenyl substituted with, heteroaryl (either 5- or 6-membered monocyclic or 8-, 9- or 10-membered bicyclic), 1 to 3 independently selected substituents R 6 heteroaryl (either 5- or 6-membered monocyclic or 8-, 9- or 10-membered bicyclic), phenyl-C1-C3-alkyl, or 1-3 independently selected substituents R 7 phenyl-C1-C3-alkyl substituted with; Q is a cyclic amine represented by formula IIa or a cyclic amine represented by formula IIb [ka] (wherein the arrow indicates the connection to the carbonyl group; p 1 is 0, 1 or 2 and indicates the number of methylene groups; p 2 is 0, 1 or 2 and indicates the number of methylene groups; q 1 is 1 or 2 and indicates the number of methylene groups; q 2is 1 or 2 and indicates the number of methylene groups; X is hydrogen, hydroxyl, alkoxy, or halogen; Y is cyano, C1-C6-alkyl, C1-C6-alkoxy-C1-C6-alkyl, C1-C6-alkylsulfanyl-C1-C6-alkyl, C1-C6-alkylsulfinyl-C1-C6-alkyl, C1-C6-alkylsulfonyl-C1-C6-alkyl, C3-C6-alkenylsulfanyl-C1-C6-alkyl, C3-C6-alkenylsulfinyl-C3-C6-alkyl, C3-C6-alkenylsulfonyl-C1-C6-alkyl, C3-C6-alkynylsulfanyl-C1-C6-alkyl, C3-C6-alkynylsulfinyl-C1-C6-alkyl, C1-C6-alkynylsulfonyl-C1-C6-alkyl, R a R b NC(O), R c C(O)NR d , R e SO2NR f , R g ON=CR h , a 4-6 membered non-aromatic heterocyclic ring system (wherein one or two carbons are independently replaced with nitrogen, oxygen, sulfur, or sulfonyl), phenyl, 1 to 3 independently selected substituents R 8 phenyl, 5- or 6-membered monocyclic heteroaryl, or 1 to 3 independently selected substituents R 9 is a 5- or 6-membered monocyclic heteroaryl substituted with A is cyano, C1-C6-cyanoalkyl, C2-C6-cyanoalkenyl, C3-C6-cyanocycloalkyl, C1-C6-haloalkyl, C1-C6-haloalkenyl, C3-C6-halocycloalkyl, C1-C6-alkoxycarbonyl, C2-C6-alkenyloxycarbonyl, C2-C6-alkynyloxycarbonyl, C1-C6-alkylsulfanyl-C1-C6-alkyl, C1-C6-alkylsulfinyl-C1-C6-alkyl, C1-C6-alkylsulfonyl-C1-C6-alkyl, R i SO2, R j R kNSO2, phenyl, 1 to 3 independently selected substituents R 10 phenyl, heteroaryl (either 5- or 6-membered monocyclic or 8-, 9- or 10-membered bicyclic), or substituted with 1 to 3 independently selected substituents R 11 heteroaryl (either 5- or 6-membered monocyclic or 8-, 9- or 10-membered bicyclic) substituted with and; R a , R b , R c , R d , R f , R g , R h , R j and R k are independently selected from hydrogen, C1-C6-alkyl, C1-C6-haloalkyl, C2-C6-alkenyl, C2-C6-haloalkenyl, C2-C6-alkynyl, C2-C6-haloalkynyl, C3-C6-cycloalkyl and C3-C6-halocycloalkyl; R e and R i are independently selected from C1-C6-alkyl, C1-C6-haloalkyl, C2-C6-alkenyl, C2-C6-haloalkenyl, C2-C6-alkynyl, C2-C6-haloalkynyl, C3-C6-cycloalkyl and C3-C6-halocycloalkyl; R 5 is halogen, cyano, C1-C6-alkyl, C1-C6-haloalkyl, C2-C6-alkenyl, C2-C6-haloalkenyl, C2-C6-alkynyl, C2-C6-haloalkynyl, C3-C6-cycloalkyl, C3-C6-halocycloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C1-C6-alkylsulfonyl, C1-C6-haloalkylsulfanyl and -OC 1-2 haloalkanediyl-O-; and R 6 , R 7 , R 8 , R 9 , R 10 , R 11are independently selected from halogen, cyano, C1-C6-alkyl, C1-C6-haloalkyl, C2-C6-alkenyl, C2-C6-haloalkenyl, C2-C6-alkynyl, C2-C6-haloalkynyl, C3-C6-cycloalkyl, C3-C6-halocycloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C1-C6-alkylsulfonyl, and C1-C6-haloalkylsulfanyl or agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of the compounds of formula (I). DETAILED DESCRIPTION OF THE INVENTION

[0005] Compounds of formula (I) having at least one basic centre can, for example, form acid addition salts with strong inorganic acids, such as mineral acids, for example perchloric acid, sulfuric acid, nitric acid, nitrous acid, phosphoric acid or hydrohalic acids; strong organic carboxylic acids, for example C1-C4 alkanecarboxylic acids which are unsubstituted or substituted, for example, by halogens, such as acetic acid; saturated or unsaturated dicarboxylic acids, for example oxalic acid, malonic acid, succinic acid, maleic acid, fumaric acid or phthalic acid; hydroxycarboxylic acids, for example ascorbic acid, lactic acid, malic acid, tartaric acid or citric acid, or for example benzoic acid; or organic sulfonic acids, for example C1-C4 alkane- or arylsulfonic acids which are unsubstituted or substituted, for example, by halogens, such as methane- or p-toluenesulfonic acid. The compounds of formula (I) having at least one acidic group can, for example, form salts with bases, for example inorganic salts, for example alkali metal or alkaline earth metal salts, for example sodium, potassium or magnesium salts, or salts with ammonia or organic amines, for example morpholine, piperidine, pyrrolidine, mono-, di- or tri-lower alkylamines, for example ethyl-, diethyl-, triethyl- or dimethylpropylamine, or mono-, di- or trihydroxy-lower alkylamines, for example mono-, di- or triethanolamine.

[0006] In each case, the compounds of formula (I) according to the invention are in free form, in oxidized form as N-oxides or in salt form, for example in agriculturally usable salt form.

[0007] N-oxides are oxidized forms of tertiary amines or nitrogen-containing aromatic heterocyclic compounds, as described, for example, in the book "Heterocyclic N-oxides", A. Albini and S. Pietra, CRC Press, Boca Raton 1991.

[0008] The compounds of formula (I) according to the present invention also include hydrates which may be formed during salt formation.

[0009] As used herein, "C1-C n The term "alkyl" refers to a saturated straight or branched hydrocarbon radical having 1 to n carbon atoms attached via any of the carbon atoms, such as any one of the radicals methyl, ethyl, n-propyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, 2,2-dimethylpropyl, 1-ethylpropyl, n-hexyl, n-pentyl, 1,1-dimethylpropyl, 1,2-dimethylpropyl, 1-methylpentyl, 2-methylpentyl, 3-methylpentyl, 4-methylpentyl, 1,1-dimethylbutyl, 1,2-dimethylbutyl, 1,3-dimethylbutyl, 2,2-dimethylbutyl, 2,3-dimethylbutyl, 3,3-dimethylbutyl, 1-ethylbutyl, 2-ethylbutyl, 1,1,2-trimethylpropyl, 1,2,2-trimethylpropyl, 1-ethyl-1-methylpropyl or 1-ethyl-2-methylpropyl.

[0010] As used herein, "C2-C n The term "alkenyl" refers to a straight or branched alkenyl chain having 2 to n carbon atoms and one or two double bonds, for example, ethenyl, prop-1-enyl, but-2-enyl.

[0011] As used herein, "C2-Cn The term "alkynyl" refers to a straight or branched alkynyl chain having 2 to n carbon atoms and one triple bond, for example, ethynyl, prop-2-ynyl, but-3-ynyl.

[0012] As used herein, "C3-C n The term "cycloalkyl" refers to a 3 to n-membered cycloalkyl group, such as cyclopropane, cyclobutane, cyclopropane, cyclopentane, and cyclohexane.

[0013] As used herein, "C1-C n The term "alkoxy" refers to a straight or branched saturated alkyl radical having 1 to n carbon atoms (as defined above) attached through an oxygen atom, i.e., for example, any one of methoxy, ethoxy, n-propoxy, 1-methoxyethoxy, n-butoxy, 1-methylpropoxy, 2-methylpropoxy, or 1,1-dimethylethoxy radicals. As used herein, "haloC1-C n The term "alkoxy" refers to a C1-C alkyl radical in which one or more hydrogen atoms on the alkyl radical are replaced by the same or different halo atoms. n It refers to an alkoxy radical (examples include trifluoromethoxy, 2-fluoroethoxy, 3-fluoropropoxy, 3,3,3-trifluoropropoxy, and 4-chlorobutoxy). Two adjacent substituents on a phenyl ring, together with carbons on the phenyl ring, can form a 5- or 6-membered ring. Examples are -OCF2O- and -OCF2CF2O-.

[0014] Halogen is generally fluorine, chlorine, bromine or iodine. This applies correspondingly to halogen in combination with other meanings, such as haloalkyl.

[0015] As used herein, "C1-C nThe term "haloalkyl" refers to a straight or branched saturated alkyl radical having 1 to n carbon atoms bonded via any of the carbon atoms (as defined above), wherein some or all of the hydrogen atoms in these radicals may be replaced by fluorine, chlorine, bromine and / or iodine, i.e., for example, chloromethyl, dichloromethyl, trichloromethyl, fluoromethyl, difluoromethyl, trifluoromethyl, chlorofluoromethyl, dichlorofluoromethyl, chlorodifluoromethyl, 2-fluoroethyl, 2-chloroethyl, 2-bromoethyl, 2-iodoethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, 2-chloro-2-fluoroethyl, 2-chloro-2,2-difluoroethyl, and any one of 2,2-dichloro-2-fluoroethyl, 2,2,2-trichloroethyl, pentafluoroethyl, 2-fluoropropyl, 3-fluoropropyl, 2,2-difluoropropyl, 2,3-difluoropropyl, 2-chloropropyl, 3-chloropropyl, 2,3-dichloropropyl, 2-bromopropyl, 3-bromopropyl, 3,3,3-trifluoropropyl, 3,3,3-trichloropropyl, 2,2,3,3,3-pentafluoropropyl, heptafluoropropyl, 1-(fluoromethyl)-2-fluoroethyl, 1-(chloromethyl)-2-chloroethyl, 1-(bromomethyl)-2-bromoethyl, 4-fluorobutyl, 4-chlorobutyl, 4-bromobutyl, and nonafluorobutyl. The term "C1-C2 fluoroalkyl" refers to a C1-C2 alkyl radical having 1, 2, 3, 4 or 5 fluorine atoms, such as any one of difluoromethyl, trifluoromethyl, 1-fluoroethyl, 2-fluoroethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, 1,1,2,2-tetrafluoroethyl or pentafluoroethyl. Similarly, as used herein, "C2-C n Haloalkenyl" or "C2-C n The term "haloalkynyl" refers to C-C alkyl groups each substituted with one or more halo atoms, which may be the same or different. n Alkenyl or C2-C nSimilarly, as used herein, "C3-C" refers to an alkynyl moiety. n The term "halocycloalkyl" refers to a C-C alkyl group substituted with one or more halo atoms, which may be the same or different. n It refers to a cycloalkyl group.

[0016] As used herein, "C1-C n The term "cyanoalkyl" refers to a C1-C6 alkyl group having 1 to n carbon atoms (as defined above). n "C1-C4 alkyl radicals" refers to alkyl radicals in which one of the hydrogen atoms in these radicals is replaced by a cyano group, such as cyanomethyl, 2-cyanoethyl, 2-cyanopropyl, 3-cyanopropyl, 1-(cyanomethyl)-2-ethyl, 1-(methyl)-2-cyanoethyl, 4-cyanobutyl, etc. Similarly, "C1-C4 alkyl radicals" refers to alkyl radicals in which one of the hydrogen atoms in these radicals is replaced by a cyano group, such as cyanomethyl, 2-cyanoethyl, 2-cyanopropyl, 3-cyanopropyl, 1-(cyanomethyl)-2-ethyl, 1-(methyl)-2-cyanoethyl, 4-cyanobutyl, etc. n Cyanoalkenyl" or "C1-C n The term "cyanoalkynyl" refers to C-C alkyl groups each of which is substituted with one of the hydrogen atoms in the corresponding moiety by a cyano group. n Alkenyl or C1-C n Refers to the alkynyl moiety.

[0017] As used herein, "C1-C n -Alkylsulfanyl-C1-C n The term "-alkyl" refers to an alkyl group in which one of the non-terminal carbon atoms has been replaced by a sulfur atom.

[0018] As used herein, "C1-C n -Alkylsulfinyl-C1-C n The term "-alkyl" refers to an alkyl group in which one of the non-terminal carbon atoms is replaced by an S(=O) group.

[0019] As used herein, "C1-C n -Alkylsulfonyl-C1-C nThe term "-alkyl" refers to an alkyl group in which one of the non-terminal carbon atoms is replaced by an S(=O)2 group.

[0020] As used herein, "C1-C n -Alkylsulfonyl-C3~C n The term "-cycloalkyl" refers to C1-C n C3-C substituted with alkylsulfonyl groups n -refers to a cycloalkyl group.

[0021] As used herein, the term "4-6 membered non-aromatic heterocyclic ring system in which one or two carbons are replaced by nitrogen, oxygen, sulfur, or sulfonyl" refers to a cyclic group in which one or two carbon atoms in the ring are independently replaced by nitrogen, oxygen, sulfur, or sulfonyl, and the ring is bonded to the remainder of the compound through a carbon or nitrogen atom. Examples are azetidinyl, oxetanyl, thietanyl, pyrrolidinyl, tetrahydrofuranyl, 2-oxopyrrolidinyl, 2-oxotetrahydrofuranyl, 1,1-dioxo-1,2-thiazolidinyl, 1,3-dioxolanyl, 1,3-dithiolanyl, 2-oxooxazolidinyl, piperidinyl, tetrahydropyranyl, 2-oxopiperidinyl, 1,1-dioxothiazinanyl, 2-oxotetrahydropyranyl, 1,3-dioxolanyl, 1,3-dithianyl, 2-oxo-1,3-oxazinanyl.

[0022] As used herein, "phenyl-C1-C n The term "alkyl" refers to an alkyl radical substituted on a phenyl ring. Phenyl-C n If there is substitution on the alkyl group, the substitution is on the phenyl ring.

[0023] As used herein, the term "5- or 6-membered monocyclic heteroaryl" refers to a 5- or 6-membered aromatic ring having 1 to 3 carbon atoms independently substituted by nitrogen, sulfur, or oxygen. Examples are pyridyl (or pyridinyl), pyridazinyl, pyrimidinyl, pyrazinyl, pyrrolyl, pyrazolyl, imidazolyl, triazolyl (e.g., 1.2.4 triazolyl), furanyl, thiophenyl, oxazolyl, isoxazolyl, oxadiazolyl, thiazolyl, isothiazolyl, and thiadiazolyl.

[0024] As used herein, the term "8-, 9-, or 10-membered bicyclic heteroaryl" refers to an 8-, 9-, or 10-membered aromatic ring consisting of two rings having 1 to 4 carbon atoms, each independently substituted by nitrogen, sulfur, or oxygen (the heteroatoms can be in one ring or distributed between the two rings). Examples include purinyl, quinolinyl, isoquinolinyl, cinnolinyl, quinoxalinyl, indolyl, indazolyl, 2,1,3-benzoxadiazolyl, 2,1,3-benzothiadiazolyl, benzimidazolyl, benzothiophenyl, benzoxazolyl, benzothiazolyl, imidazo[1,2-a]pyridinyl, imidazo[4,5-b]pyridinyl, imidazo[2,1-b]thiazole, and imidazo[2,1-b][1,3,4]thiadiazolyl.

[0025] As used herein, "C1-C n -Alkoxy-C1~C n The term "-alkyl" refers to C1-C n -refers to an alkyl group substituted with an alkoxy group. Examples are methoxymethyl, methoxyethyl, ethoxymethyl and propoxymethyl.

[0026] As used herein, "C1-C n -Haloalkoxy-C1~C n The term "-alkyl" refers to C1-C n -refers to an alkyl group substituted with a haloalkoxy group. Examples are trifluoromethoxymethyl and chloromethoxymethyl.

[0027] As used in this specification, "C2 to C n -Alkenyloxy-C1~C n -alkyl" and "C2-C n -Haloalkenyloxy-C1~C n The term "-alkyl" refers to a C1-C alkyl group, each of which is joined via an oxygen atom. n - C2-C bonded to the alkyl group and the bond to the rest of the compound is through a carbon atom of the alkyl group n -Alkenyl group and C2-C n -refers to a haloalkenyl group.

[0028] As used in this specification, "C2 to C n -Alkynyloxy-C1~C n -alkyl" and "C2-C n -Haloalkynyloxy-C1~C n The term "-alkyl" refers to a C1-C alkyl group, each of which is joined via an oxygen atom. n - C2-C bonded to the alkyl group and the bond to the rest of the compound is through a carbon atom of the alkyl group n -alkynyl group and C2-C n -refers to a haloalkynyl group.

[0029] As used in this specification, "C3 to C n -Cycloalkoxy-C1~C n -alkyl" and "C3-C n -Halocycloalkoxy-C1~C n The terms "C3-C-alkyl" and "C4-C6-C8-C9-C10-C12-C14-C16-C18-C19-C20-C22-C24-C26-C28-C30-C31-C26-C28 ... n -cycloalkoxy" and "C3-C n -halocycloalkoxy" refers to an alkyl group substituted with a "-halocycloalkoxy" group.

[0030] As used herein, "C1-C n The term "alkoxycarbonyl" refers to a carbonyl (C=O) radical (through which C1-C nC1-C bonded to the alkoxycarbonyl) n It refers to an alkoxy group. Examples are methoxycarbonyl, ethoxycarbonyl, isopropoxycarbonyl and tert-butyloxycarbonyl.

[0031] As used herein, "C2-C n The term "alkenyloxycarbonyl" refers to a carbonyl (C=O) radical bonded by an oxygen atom to a C-C n It refers to an alkenyl group where the bond to the rest of the compound is through the carbon atom of the carbonyl. Examples are vinyloxycarbonyl and allyloxycarbonyl.

[0032] As used herein, "C2-C n The term "alkynyloxycarbonyl" refers to a carbonyl (C=O) radical bonded by an oxygen atom to a C-C n

[0033] Refers to an alkynyl group where the bond to the rest of the compound is through the carbon atom of the carbonyl. Examples are propargyloxycarbonyl (2-prop-2-ynoxycarbonyl) and 2-pent-3-ynoxycarbonyl.

[0033] As used herein, "-OC 1-2 The term "haloalkanediyl-O-" means that adjacent positions on the phenyl ring are -OC 1-2 It refers to a haloalkanediyl-O- group linked by one to two carbon atoms attached to the oxygen atom and where the oxygen atom is replaced by one or more halogen atoms. Examples are -OCF2O- and -OCF2CF2O-.

[0034] As used herein, the term "control" refers to reducing the number of pests so that damage to plants or plant-derived products is reduced, eradicating pests, and / or preventing further pest damage.

[0035] As used herein, the term "pest" refers to insects and mollusks found in agriculture, horticulture, forestry, and storage of plant-derived products (such as fruit, grain, and lumber); and pests associated with damage to man-made structures. The term pest encompasses all stages in the life cycle of a pest.

[0036] As used herein, the term "effective amount" refers to that amount of a compound or salt thereof that produces a desired effect in single or multiple applications.

[0037] An effective amount is readily determined by one skilled in the art by the use of known techniques and by observing results obtained under analogous circumstances. Determining an effective amount takes into account numerous factors, including, but not limited to, the type of plant or plant-derived product to which it is applied; the pest to be controlled and its life cycle; the particular compound applied; the type of application; and other relevant circumstances.

[0038] Embodiments according to the present invention are provided as follows.

[0039] In one embodiment of each aspect of the invention, R 1 teeth, A. CN or C(=S)NH2; or B.CN.

[0040] In one embodiment of each aspect of the invention, R 2 teeth, A. hydrogen, halogen, C1-C6 alkoxy or C1-C6 haloalkoxy; or B. It is hydrogen.

[0041] In an embodiment of each aspect of the present invention, R 3 teeth A. C1-C4-alkoxy-C1-C3-alkyl, C1-C4-haloalkoxy-C1-C3-alkyl, C2-C4-alkenyloxy-C1-C3-alkyl, C2-C4-haloalkenyloxy-C1-C3-alkyl, C2-C4-alkynyloxy-C1-C3-alkyl, C2-C4-haloalkynyloxy-C1-C3-alkyl, C3-C6-cycloalkoxy-C1-C3-alkyl, C3-C6-halocycloalkoxy-C1-C3-alkyl, C1-C4-alkylsulfonyl-C1-C3-alkyl; C1-C4-alkylsulfonyl-C3-C6-cycloalkyl, C1-C4-cyanoalkyl or C3-C6-cyanocycloalkyl; or B. C1-C3-alkoxy-C1-C3-alkyl, C1-C3-alkylsulfonyl-C1-C3-alkyl; C1-C3-alkylsulfonyl-C3-C3-cycloalkyl, C1-C3-cyanoalkyl or C3-C6-cyanocycloalkyl; or C. C1-C3-alkoxy-C1-C3-alkyl, C1-C3-alkylsulfonyl-C1-C3-alkyl; C1-C3-alkylsulfonyl-cyclopropyl, C1-C3-cyanoalkyl or cyano-cyclopropyl; or D. C1-C2-alkoxy-C1-C2-alkyl, C1-C2-alkylsulfonyl-C1-C2-alkyl; C1-C2-alkylsulfonyl-cyclopropyl, C1-C2-cyanoalkyl or cyano-cyclopropyl; or E. methoxymethyl, ethoxymethyl, methysulfonylmethyl, methysulfonylcyclopropyl, cyano-methyl or cyano-cyclopropyl; or F. methoxymethyl, methysulfonylmethyl, or cyano-methyl; or G.Methoxymethyl is.

[0042] In an embodiment of each aspect of the present invention, R 4 teeth, A. C1-C6-haloalkyl, C2-C6-alkenyl, C2-C6-haloalkenyl, C3-C6-cycloalkyl, C3-C6-halocycloalkyl, phenyl, 1 to 3 independently selected substituents R 5 phenyl substituted with 5- or 6-membered monocyclic heteroaryl, 1 to 3 independently selected substituents R 6 5- or 6-membered monocyclic heteroaryl optionally substituted with one to three independently selected substituents R 6 8-, 9-, or 10-membered bicyclic heteroaryl optionally substituted with phenyl-C1-C3-alkyl, or 1 to 3 independently selected substituents R 7 phenyl-C1-C3-alkyl substituted with; or B. C1-C6-haloalkyl, C2-C6-haloalkenyl, C3-C6-cycloalkyl or C3-C6-halocycloalkyl, 1 to 3 independently selected substituents R 5 phenyl substituted with 5- or 6-membered monocyclic heteroaryl, 1 to 3 independently selected substituents R 6 5- or 6-membered monocyclic heteroaryl substituted with 1 to 3 independently selected substituents R 6 8-, 9-, or 10-membered bicyclic heteroaryl optionally substituted with phenyl-C1-C3-alkyl, or 1 to 3 independently selected substituents R 7 phenyl-C1-C3-alkyl substituted with; or C. 1 to 3 independently selected substituents R 5 phenyl substituted with 1 to 3 independently selected substituents R 6 or 5- or 6-membered monocyclic heteroaryl substituted with 1 to 3 independently selected substituents R 6 an 8-, 9-, or 10-membered bicyclic heteroaryl optionally substituted with D. Substituted with 1 to 3 substituents independently selected from halogen, cyano, C1-C6-alkyl, C1-C6-haloalkyl, C2-C6-alkenyl, C2-C6-haloalkenyl, C2-C6-alkynyl, C2-C6-haloalkynyl, C3-C6-cycloalkyl, C3-C6-halocycloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C1-C6-alkylsulfonyl, and C1-C6-haloalkylsulfanyl or any of thiophenyl, thiazolyl, thiadiazolyl, pyridyl (or pyridinyl), pyrazolyl, 2,1,3-benzoxadiazolyl and 1,3-benzodioxolyl, which are, independently of one another, unsubstituted or substituted by 1 to 3 substituents independently selected from halogen, C1-C3-alkyl, C1-C3-haloalkyl, C1-C3-alkoxy; and C1-C3-haloalkoxy; or E. Halogen, cyano, C1-C6-haloalkyl, C1-C6-haloalkoxy, C1-C6-alkylsulfonyl, C1-C6-haloalkylsulfanyl and -OC 1-2 Phenyl substituted by 1 to 3 substituents independently selected from haloalkanediyl-O-, or any of thiophenyl, thiazolyl, thiadiazolyl, pyridyl (or pyridinyl), pyrazolyl, 2,1,3-benzoxadiazolyl, and 1,3-benzodioxolyl, which are, independently of one another, unsubstituted or substituted by 1 to 3 substituents independently selected from fluorine, chlorine, methyl, ethyl, isopropyl, trifluoromethyl, difluoromethyl, trifluoromethoxy, and difluoromethoxy; or F. Halogen, cyano, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-haloalkoxy, C1-C6-alkylsulfonyl, C1-C6-haloalkylsulfanyl and -OC 1-2Phenyl substituted by one or two substituents independently selected from haloalkanediyl-O-, or any of thiophenyl, pyridyl (or pyridinyl), and pyrazolyl, each of which is substituted by one to three substituents independently selected from fluorine, chlorine, methyl, ethyl, isopropyl, trifluoromethyl, difluoromethyl, trifluoromethoxy, and difluoromethoxy; or G. Halogen, cyano, C1-C6-haloalkoxy, C1-C6-haloalkyl and -OC 1-2 Phenyl substituted by one or two substituents independently selected from haloalkanediyl-O—, or any of thiophenyl, pyridyl (or pyridinyl) and pyrazolyl, each of which is substituted by one to two substituents independently selected from halogen, C1-C6-haloalkoxy, C1-C6-alkyl and C1-C6-haloalkyl; or H. Halogen, cyano, C1-C3-alkylsulfonyl, C1-C3-haloalkylsulfanyl, C1-C3-haloalkoxy, C1-C3-haloalkyl and -OC 1-2 Phenyl substituted with haloalkanediyl-O—, or any of thiophenyl, pyridyl (or pyridinyl) and pyrazolyl, each of which is substituted with 1 to 2 substituents independently selected from halogen, C1-C3-haloalkoxy, C1-C3-alkyl and C1-C3-haloalkyl; or I. Halogen, cyano, C1-C3-alkylsulfonyl, C1-C3-haloalkylsulfanyl, C1-C3-haloalkoxy, C1-C3-haloalkyl and -OC 1-2 phenyl substituted with 1 to 3 substituents independently selected from haloalkanediyl-O-; or J. Halogen, cyano, C1-C3-haloalkoxy, C1-C3-haloalkyl and -OC 1-2 phenyl substituted with 1 to 3 substituents independently selected from haloalkanediyl-O-; or K. Thiophenyl, pyridyl (or pyridinyl), and pyrazolyl, each of which is substituted with 1 to 2 substituents independently selected from halogen, C1-C3-haloalkoxy, C1-C3-alkyl, and C1-C3-haloalkyl; or 2,1,3-benzoxadiazolyl. is.

[0043] In an embodiment of each aspect of the invention, Q is A. Cyclic amines represented by formula IIa, wherein p 1 and p 2 are both 1; X is hydrogen, hydroxyl, alkoxy or halogen; and Y is cyano, C1-C6-alkyl, C1-C6-alkoxy-C1-C6-alkyl, C1-C6-alkylsulfanyl-C1-C6-alkyl, C1-C6-alkylsulfinyl-C1-C6-alkyl, C1-C6-alkylsulfonyl-C1-C6-alkyl, R a R b NC(O), R c C(O)NR d , R e SO2NR f , R g ON=CR h , a 4-6 membered non-aromatic heterocyclic ring system (wherein 1 or 2 carbons are independently replaced with nitrogen, oxygen, sulfur, or sulfonyl), phenyl, 1-3 substituents R 8 phenyl, 5- or 6-membered monocyclic heteroaryl, or 1 to 3 substituents R 9 is a 5- or 6-membered monocyclic heteroaryl substituted with [ka] B. Cyclic amines represented by formula IIa, wherein p 1 and p 2are both 1; X is hydrogen or hydroxyl; and Y is selected from cyano, C1-C6-alkyl, C1-C6-alkoxy-C1-C6-alkyl, C1-C6-alkylsulfanyl-C1-C6-alkyl, C1-C6-alkylsulfinyl-C1-C6-alkyl, C1-C6-alkylsulfonyl-C1-C6-alkyl, R a R b NC(O), R c C(O)NR d , R e SO2NR f , R g ON=CR h , a 4-6 membered non-aromatic heterocyclic ring system (wherein 1 or 2 carbons are independently replaced with nitrogen, oxygen, sulfur, or sulfonyl), phenyl, 1-3 substituents R 8 phenyl, 5- or 6-membered monocyclic heteroaryl, or 1 to 3 substituents R 9 is a 5- or 6-membered monocyclic heteroaryl substituted with C. Cyclic amines represented by formula IIa, wherein p 1 and p 2 are both 1, X is hydrogen or hydroxyl; and Y is selected from cyano, C1-C6-alkylsulfanyl-C1-C6-alkyl, C1-C6-alkylsulfinyl-C1-C6-alkyl, C1-C6-alkylsulfonyl-C1-C6-alkyl, R a R b NC(O), R e SO2NR f , R g ON=CR h , a 4-6 membered non-aromatic heterocyclic ring system (wherein 1 or 2 carbons are independently replaced with nitrogen, oxygen, sulfur, or sulfonyl), phenyl, 1-3 substituents R 8 phenyl, 5- or 6-membered monocyclic heteroaryl, or 1 to 3 substituents R 9 is a 5- or 6-membered monocyclic heteroaryl substituted with D. Cyclic amines represented by formula IIa, wherein p 1 and p 2are both 1, X is hydrogen or hydroxyl; and Y is cyano, C1-C6-alkylsulfanyl-C1-C6-alkyl, C1-C6-alkylsulfinyl-C1-C6-alkyl, C1-C6-alkylsulfonyl-C1-C6-alkyl, a 4- to 6-membered non-aromatic heterocyclic ring system in which 1 or 2 carbons are independently replaced by nitrogen, oxygen, sulfur, or sulfonyl, a 5- or 6-membered monocyclic heteroaryl, or 1 to 3 substituents R 9 is a 5- or 6-membered monocyclic heteroaryl substituted with E. Cyclic amines represented by formula IIa, wherein p 1 and p 2 are both 1, X is hydrogen or hydroxyl; and Y is a 5- or 6-membered monocyclic heteroaryl or one to three substituents R 9 is a 5- or 6-membered monocyclic heteroaryl substituted with F. Cyclic amines represented by formula IIa, wherein p 1 and p 2 are both 1, X is hydrogen or hydroxyl; and Y is a 5- or 6-membered monocyclic heteroaryl substituted with 1 to 3 substituents independently selected from halogen, C1-C6-alkyl, and C1-C6-haloalkyl; or G. Cyclic amines represented by formula IIa, wherein p 1 and p 2 are both 1, X is hydrogen or hydroxyl; and Y is C1-C3-alkoxy-C1-C3-alkyl, C1-C3-alkylsulfanyl-C1-C3-alkyl, C1-C3-alkylsulfinyl-C1-C3-alkyl or C1-C3-alkylsulfonyl-C1-C3-alkyl); or H. Cyclic amines represented by formula IIa, wherein p 1 and p 2are both 1, X is hydrogen; and Y is methoxymethyl, ethylsulfanylmethyl, ethylsulfinylmethyl, ethylsulfonylmethyl, 1-methyl-1,2,4-triazol-3-yl, 1,1-dioxo-1,2-thiazolidin-2-yl, 1-methylpyrazol-3-yl, 5-methyl-1,1-dioxo-1,2,5-thiadiazolidin-2-yl, or 5-ethyl-1,1-dioxo-1,2,5-thiadiazolidin-2-yl); or I. Cyclic amines represented by formula IIb, wherein q 1 and q 2 are both 1; and A is cyano, C1-C6-cyanoalkyl, C2-C6-cyanoalkenyl, C3-C6-cyanocycloalkyl, C1-C6-haloalkyl, C1-C6-haloalkenyl, C3-C6-halocycloalkyl, C1-C6-alkoxycarbonyl, C2-C6-alkenyloxycarbonyl, C2-C6-alkynyloxycarbonyl, R i SO2, R j R k NSO2, phenyl, 1 to 3 substituents R 10 phenyl, heteroaryl (either 5- or 6-membered monocyclic or 8-, 9- or 10-membered bicyclic), or 1 to 3 substituents R 11 heteroaryl (either 5- or 6-membered monocyclic or 8-, 9-, or 10-membered bicyclic) substituted with [ka] J. Cyclic amines represented by formula IIb, wherein q 1 and q 2 are both 1; and A is selected from the group consisting of cyano, C1-C6-cyanoalkyl, C1-C6-haloalkyl, C1-C6-alkoxycarbonyl, C2-C6-alkenyloxycarbonyl, C1-C6-alkylsulfanyl-C1-C6-alkyl, C1-C6-alkylsulfinyl-C1-C6-alkyl, C1-C6-alkylsulfonyl-C1-C6-alkyl, phenyl, 1 to 3 substituents R 10phenyl, heteroaryl (either 5- or 6-membered monocyclic or 8-, 9- or 10-membered bicyclic), or 1 to 3 substituents R 11 heteroaryl (either 5- or 6-membered monocyclic or 8-, 9-, or 10-membered bicyclic) substituted with K. Cyclic amines represented by formula IIb, wherein q 1 and q 2 are both 1; and A is R i SO2, R j R k NSO2, phenyl, 1 to 3 substituents R 10 phenyl, 5- or 6-membered monocyclic heteroaryl, or 1 to 3 substituents R 11 is a 5- or 6-membered monocyclic heteroaryl substituted with L. Cyclic amines represented by formula IIb, wherein q 1 and q 2 are both 1; and A is C1-C3-alkylsulfonyl, (C1-C3-alkyn)HNSO2, (C1-C3-alkyn)2NSO2, phenyl substituted with 1 to 3 substituents independently selected from halogen, C1-C3-alkyl and C1-C3-haloalkyl, or a 5- or 6-membered monocyclic heteroaryl substituted with 1 to 3 substituents independently selected from halogen, C1-C3-alkyl and C1-C3-haloalkyl; or M. Cyclic amines represented by formula IIb, wherein q 1 and q 2 are both 1; and A is ethylsulfonyl, propylsulfonyl, iso-propylsulfonyl, cyclopropylsulfonyl, methylsulfamoyl, ethylsulfamoyl, dimethylsulfamoyl, ethyl(methyl)sulfamoyl, 4-fluoro-phenyl, 3,5-dichloropyridin-2-yl, 4-fluoro-pyridin-2-yl, 5-methyl-1,2,4-oxadiazol-3-yl, 3-methyl-1,2,4-oxadiazol-5-yl, or 1-methylpyrazol-3-yl. is.

[0044] In one embodiment of each aspect of the invention, R a , R b , R c , R d , R f , R g , R h , R j and R k is, independently, A. hydrogen, C1-C3 alkyl, C1-C3 haloalkyl, C2-C4 alkenyl, C2-C4 haloalkenyl, C2-C4 alkynyl, C2-C4 haloalkynyl, C3-C4 cycloalkyl, and C3-C4 halocycloalkyl; or B. hydrogen, C1-C3 alkyl, C1-C3 haloalkyl, C3-C4 cycloalkyl, and C3-C4 halocycloalkyl; or C. hydrogen, C1-C3 alkyl, C1-C3 haloalkyl, and C3-C4 halocycloalkyl; or D. hydrogen, C1-C3 alkyl, and C1-C3 haloalkyl; or E. selected from hydrogen and C1-C3 haloalkyl.

[0045] In one embodiment of each aspect of the invention, R e and R i is, independently, A. C1-C3 alkyl, C1-C3 haloalkyl, C2-C4 alkenyl, C2-C4 haloalkenyl, C2-C4 alkynyl, C2-C4 haloalkynyl, C3-C4 cycloalkyl and C3-C4 halocycloalkyl; or B. C1-C3 alkyl, C1-C3 haloalkyl, C2-C4 alkenyl, C2-C4 haloalkenyl, C2-C4 alkynyl, C2-C4 haloalkynyl, C3-C4 cycloalkyl and C3-C4 halocycloalkyl; or C is selected from C1-C3 alkyl and C1-C3 haloalkyl.

[0046] In one embodiment of each aspect of the invention, R 6 , R 7 , R 8 , R 9, R 10 , R 11 is, independently, A. halogen, cyano, C1-C3 alkyl, C1-C3 haloalkyl, C2-C4 alkenyl, C2-C4 haloalkenyl, C2-C4 alkynyl, C2-C4 haloalkynyl, C3-C4 cycloalkyl, C3-C4 halocycloalkyl, C1-C3 alkoxy; C1-C3 haloalkoxy; C1-C3 alkylsulfonyl, and C1-C3 haloalkylsulfanyl; or B. halogen, cyano, C1-C3 alkyl, C1-C3 haloalkyl, C3-C4 cycloalkyl, C3-C4 halocycloalkyl, C1-C3 alkoxy; C1-C3 haloalkoxy; C1-C3 alkylsulfonyl, and C1-C3 haloalkylsulfanyl; or C. halogen, cyano, C1-C3 alkyl, C1-C3 haloalkyl, C3-C4 cycloalkyl, C3-C4 halocycloalkyl, C1-C3 alkoxy; and C1-C3 haloalkoxy; or D. halogen, C1-C3 alkyl, C1-C3 haloalkyl, C1-C3 alkoxy; and C1-C3 haloalkoxy; or E. halogen, C1-C3 alkyl, C1-C3 haloalkyl, C1-C3 alkoxy; and C1-C3 haloalkoxy; or F. halogen, C1-C3 alkyl, and C1-C3 haloalkyl and C1-C3 haloalkoxy; or G. Selected from fluorine, bromine, chlorine, methyl, ethyl, isopropyl, trifluoroethyl, trifluoromethyl, difluoromethyl, trifluoromethoxy, and difluoromethoxy.

[0047] In an embodiment of each aspect of the present invention, R 5 teeth, A. Halogen, cyano, C1-C3-alkyl, C1-C3-haloalkyl, C2-C4-alkenyl, C2-C4-haloalkenyl, C2-C4-alkynyl, C2-C4-haloalkynyl, C3-C4-cycloalkyl, C3-C4-halocycloalkyl, C1-C3-alkoxy; C1-C3-haloalkoxy; C1-C3-alkylsulfonyl, C1-C3-haloalkylsulfanyl and -OC 1-2 haloalkanediyl-O-; or B. halogen, cyano, C1-C3-alkyl, C1-C3-haloalkyl, C3-C4-cycloalkyl, C3-C4-halocycloalkyl, C1-C3-alkoxy; C1-C3-haloalkoxy; C1-C3-alkylsulfonyl, C1-C3-haloalkylsulfanyl and -OC1-C2-haloalkylO-; or C. halogen, cyano, C1-C3-alkyl, C1-C3-haloalkyl, C3-C4-cycloalkyl, C3-C4-halocycloalkyl, C1-C3-alkoxy, C1-C3-haloalkoxy and -OC1-C2-haloalkylO-; or D. halogen, C1-C3-alkyl, C1-C3-haloalkyl, C1-C3-alkoxy; C1-C3-haloalkoxy and -OC1-C2-haloalkylO-; or E. halogen, C1-C3-alkyl, C1-C3-haloalkyl, C1-C3-alkoxy; C1-C3-haloalkoxy and -OC1-C2-haloalkylO-; or F. halogen, C1-C3-alkyl, and C1-C3-haloalkyl, C1-C3-haloalkoxy and -OC1-C2-haloalkylO-; or G. Fluorine, bromine, chlorine, methyl, ethyl, isopropyl, trifluoroethyl, trifluoromethyl, difluoromethyl, trifluoromethoxy, difluoromethoxy, -OCF2O- and -OCF2CF2O- are independently selected from

[0048] The present invention therefore provides a compound comprising the substituent R 1 , R 2 , R 3 , R4 and Q in all combinations / permutations thereof. Thus, for example, R 1 is the first embodiment (i.e., R 1 is CN or C(=S)NH2); R 2 In embodiment B (i.e., R 2 is hydrogen); R 3 In embodiment A (i.e., R 3 is C1-C4-alkoxy-C1-C3-alkyl, C1-C4-haloalkoxy-C1-C3-alkyl, C2-C4-alkenyloxy-C1-C3-alkyl, C2-C4-haloalkenyloxy-C1-C3-alkyl, C2-C4-alkynyloxy-C1-C3-alkyl, C2-C4-haloalkynyloxy-C1-C3-alkyl, C3-C6-cycloalkoxy-C1-C3-alkyl, C3-C6-halocycloalkoxy-C1-C3-alkyl, C1-C4-alkylsulfonyl-C1-C3-alkyl; C1-C4-alkylsulfonyl-C3-C6-cycloalkyl, C1-C4-cyanoalkyl or C3-C6-cyanocycloalkyl); R 4 In embodiment C (i.e., R 4 is one to three independently selected substituents R 5 phenyl substituted with 1 to 3 independently selected substituents R 6 or 5- or 6-membered monocyclic heteroaryl substituted with 1 to 3 independently selected substituents R 6 Q is embodiment C (i.e., Q is a cyclic amine represented by formula IIa, wherein p 1 and p 2 are both 1, X is hydrogen or hydroxyl; and Y is selected from cyano, C1-C6-alkylsulfanyl-C1-C6-alkyl, C1-C6-alkylsulfinyl-C1-C6-alkyl, C1-C6-alkylsulfonyl-C1-C6-alkyl, R a R b NC(O), R e SO2NR f , Rg ON=CR h , a 4-6 membered non-aromatic heterocyclic ring system (wherein one or two carbons are independently replaced with nitrogen, oxygen, sulfur, or sulfonyl), phenyl, 1 to 3 independently selected substituents R 8 phenyl, 5- or 6-membered monocyclic heteroaryl, or 1 to 3 independently selected substituents R 9 wherein R is a 5- or 6-membered monocyclic heteroaryl substituted with a is embodiment C (i.e., R a is hydrogen, C1-C3-alkyl, C1-C3-haloalkyl, or C3-C4-halocycloalkyl; R b is embodiment D (i.e., R b is hydrogen, C1-C3-alkyl or C1-C3-haloalkyl; R e is embodiment C (i.e., R e is C1-C3-alkyl or C1-C3-haloalkyl; R f is embodiment A (i.e., R f is hydrogen, C1-C3-alkyl, C1-C3-haloalkyl, C2-C4-alkenyl, C2-C4-haloalkenyl, C2-C4-alkynyl, C2-C4-haloalkynyl, C3-C4-cycloalkyl and C3-C4-halocycloalkyl); R g is embodiment A (i.e., R g is hydrogen, C1-C3-alkyl, C1-C3-haloalkyl, C2-C4-alkenyl, C2-C4-haloalkenyl, C2-C4-alkynyl, C2-C4-haloalkynyl, C3-C4-cycloalkyl and C3-C4-halocycloalkyl); R h is embodiment C (i.e., R h is hydrogen, C1-C3-alkyl, C1-C3-haloalkyl, or C3-C4-halocycloalkyl; R 5 is embodiment C (i.e., R 5is independently selected from halogen, cyano, C1-C3-alkyl, C1-C3-haloalkyl, C3-C4-cycloalkyl, C3-C4-halocycloalkyl, C1-C3-alkoxy, C1-C3-haloalkoxy and -OC1-C2-haloalkylO-; R 8 is embodiment E (i.e., R 8 is independently selected from halogen, C1-C3-alkyl, C1-C3-haloalkyl, C1-C3-alkoxy; and C1-C3-haloalkoxy; and R 9 is embodiment F (i.e., R 9 are independently selected from fluorine, bromine, chlorine, methyl, ethyl, isopropyl, trifluoroethyl, trifluoromethyl, difluoromethyl, trifluoromethoxy, and difluoromethoxy).

[0049] In an embodiment of each aspect of the invention, the compound of formula (I) has the following: R 1 is CN or C(=S)NH2; preferably CN; R 2 is H, halogen, C1-C6-alkoxy or C1-C6-haloalkoxy; preferably hydrogen; R 3 is C1-C6-alkoxy-C1-C6-alkyl, C1-C6-haloalkoxy-C1-C6-alkyl, C2-C6-alkenyloxy-C1-C6-alkyl, C2-C6-haloalkenyloxy-C1-C6-alkyl, C2-C6-alkynyloxy-C1-C6-alkyl, C2-C6-haloalkynyloxy-C1-C6-alkyl, C3-C6-cycloalkoxy-C1-C6-alkyl, C3-C6-halocycloalkoxy-C1-C6-alkyl, C1-C6-alkylsulfonyl-C1-C6-alkyl; C1-C6-alkylsulfonyl-C3-C6-cycloalkyl, C1-C6-cyanoalkyl or C3-C6-cyanocycloalkyl; R 4 is phenyl, 1 to 3 independently selected substituents R 5phenyl substituted with, heteroaryl (either 5- or 6-membered monocyclic or 8-, 9- or 10-membered bicyclic), 1 to 3 independently selected substituents R 6 heteroaryl (either 5- or 6-membered monocyclic or 8-, 9- or 10-membered bicyclic) substituted with Q is a cyclic amine represented by formula IIa or a cyclic amine represented by formula IIb [ka] (wherein the arrow indicates the connection to the carbonyl group; p 1 is 0 or 1 and indicates the number of methylene groups; p 2 is 0 or 1 and indicates the number of methylene groups; q 1 is 1 and indicates the number of methylene groups; q 2 is 1 and indicates the number of methylene groups; X is hydrogen or hydroxyl; preferably hydrogen; Y is C1-C6-alkoxy-C1-C6-alkyl, C1-C6-alkylsulfanyl-C1-C6-alkyl, C1-C6-alkylsulfinyl-C1-C6-alkyl, C1-C6-alkylsulfonyl-C1-C6-alkyl, C1-C6-alkylsulfonyl(C1-C6-alkyl)amino, C1-C6-alkoxy-N=C1-C6-alkyl, a 4- to 6-membered non-aromatic heterocyclic ring system (wherein 1 or 2 carbons are independently replaced by nitrogen and sulfonyl), phenyl, 1 to 3 independently selected substituents R 8 phenyl, 5- or 6-membered monocyclic heteroaryl, or 1 to 3 independently selected substituents R 9 is a 5- or 6-membered monocyclic heteroaryl substituted with A is C1-C3-alkylamino-sulfonyl, di(C1-C3-alkyl)amino-sulfonyl, phenyl, 1 to 3 independently selected substituents R 10phenyl, heteroaryl (either 5- or 6-membered monocyclic or 8-, 9- or 10-membered bicyclic), or substituted with 1 to 3 independently selected substituents R 11 heteroaryl (either 5- or 6-membered monocyclic or 8-, 9- or 10-membered bicyclic) substituted with and; R 5 is halogen, cyano, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C1-C6-alkylsulfonyl, C1-C6-haloalkylsulfanyl and -OC 1-2 haloalkanediyl-O-; and R 6 are independently selected from halogen, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C1-C6-alkylsulfonyl and C1-C6-haloalkylsulfanyl; R 8 are independently selected from halogen, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6- and haloalkoxy; R 9 are independently selected from halogen, C1-C6-alkyl and C1-C6-haloalkyl; R 10 are independently selected from halogen, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy and C1-C6-haloalkoxy; and R 11 are independently selected from halogen, C1-C6-alkyl and C1-C6-haloalkyl.

[0050] In an embodiment of each aspect of the invention, the compound of formula (I) is R 1 as cyano or C(=S)NH2, R 2 as hydrogen, R 3as R selected from C1-C2-alkoxy-C1-C2-alkyl, C1-C2-alkylsulfonyl-C1-C2-alkyl; C1-C2-alkylsulfonyl-cyclopropyl, C1-C2-cyanoalkyl and cyano-cyclopropyl; 4 Q is any one of phenyl, thiophenyl, pyridyl (or pyridinyl) and pyrazolyl substituted by 1 or 2 substituents independently selected from halogen, C1-C4-alkyl, C1-C4-haloalkyl, cyano, C1-C4-haloalkylsulfanyl, C1-C4-alkylsulfonyl and C1-C4-haloalkoxy, each of which is substituted by 1 to 2 substituents independently selected from fluorine, chlorine, methyl, ethyl, isopropyl, trifluoromethyl, difluoromethyl, trifluoromethoxy and difluoromethoxy; Q is a cyclic amine represented by formula IIa (wherein p 1 and p 2 are both 1, X is hydrogen or hydroxyl; and Y is selected from the group consisting of cyano, C1-C4-alkylsulfanyl-C1-C4-alkyl, C1-C4-alkylsulfinyl-C1-C4-alkyl, C1-C4-alkylsulfonyl-C1-C4-alkyl, 1,1-dioxo-1,2-thiazolidin-2-yl, N,N-di(C1-C4-alkyl)carboxamido, C1-C4-alkoxy-imino-C1-C4-alkyl. , C1-C4-alkylsulfonylamido, phenyl, phenyl substituted with 1 to 3 substituents independently selected from halogen, C1-C3-alkyl, C1-C3-haloalkyl and C1-C3-haloalkoxy, or 5- or 6-membered monocyclic heteroaryl substituted with 1 to 3 substituents independently selected from halogen, C1-C3-alkyl, C1-C3-haloalkyl and C1-C3-haloalkoxy).

[0051] In an embodiment of each aspect of the invention, the compound of formula (I) is R 1 as cyano or C(=S)NH2, R 2 as hydrogen, R 3R is selected from methoxymethyl, ethoxymethyl, methysulfonylmethyl, methysulfonylcyclopropyl, cyanomethyl and cyanocyclopropyl; 4 Q is a phenyl substituted by one or two substituents independently selected from iodo, bromo, chloro, fluoro, methyl, trifluoromethyl, trifluoroethyl, trifluoromethoxy, trifluoromethylsulfanyl, cyano, and methylsulfonyl, or any of thiophenyl, pyridyl (or pyridinyl), and pyrazolyl, each of which is substituted by one to two substituents independently selected from fluorine, chlorine, methyl, ethyl, isopropyl, trifluoromethyl, difluoromethyl, trifluoromethoxy, and difluoromethoxy; Q is a cyclic amine represented by formula IIa (wherein, p 1 and p 2 are both 1, X is hydrogen or hydroxyl; and Y is cyano, C-C-alkylsulfanyl-C-C-alkyl, C-C-alkylsulfinyl-C-C-alkyl, C-C-alkylsulfonyl-C-C-alkyl, 1,1-dioxo-1,2-thiazolidin-2-yl, N,N-di(C-C-alkyl)carboxamido, C-C-alkoxy-imino-C-C-alkyl, C-C-alkylsulfonylamido, phenyl, phenyl substituted with 1 to 3 substituents independently selected from chloro, methyl, difluoromethyl, trifluoroethyl, trifluoromethyl and trifluoromethoxy, or 5- or 6-membered monocyclic heteroaryl substituted with 1 to 3 substituents independently selected from chloro, fluoro, methyl, trifluoroethyl, trifluoromethyl and trifluoromethoxy.

[0052] In an embodiment of each aspect of the invention, the compound of formula (I) is R 1 As Cyano, R 2 as hydrogen, R 3R is selected from methoxymethyl, ethoxymethyl, methysulfonylmethyl, methysulfonylcyclopropyl, cyanomethyl and cyanocyclopropyl; 4 Q is a phenyl substituted by one or two substituents independently selected from iodo, bromo, chloro, fluoro, methyl, trifluoroethyl, trifluoromethyl, trifluoromethoxy, trifluoromethylsulfanyl, cyano, and methylsulfonyl, or any of thiophenyl, pyridyl (or pyridinyl), and pyrazolyl, each of which is substituted by one to two substituents independently selected from fluorine, chlorine, methyl, ethyl, isopropyl, trifluoromethyl, difluoromethyl, trifluoromethoxy, and difluoromethoxy; Q is a cyclic amine represented by formula IIa (wherein, p 1 and p 2 are both 1, X is hydrogen or hydroxyl; and Y is selected from the group consisting of cyano, C1-C2-alkylsulfanyl-C1-C2-alkyl, C1-C2-alkylsulfinyl-C1-C2-alkyl, C1-C2-alkylsulfonyl-C1-C2-alkyl, 1,1-dioxo-1,2-thiazolidin-2-yl, N,N-di(C1-C2-alkyl)carboxamido, C1-C2-alkoxy-imino-C1-C2-alkyl, C1-C2-alkylsulfonylamido, phenyl, chloro, methyl, difluoro phenyl substituted with 1 to 3 substituents independently selected from methyl, trifluoroethyl, trifluoromethyl, and trifluoromethoxy, or a 5- or 6-membered monocyclic heteroaryl selected from 1,2,4-oxadiazol-3-yl, pyridin-2-yl, and 1,2,4-triazol-3-yl, wherein each heteroaryl is substituted with 1 to 3 substituents independently selected from chloro, fluoro, methyl, trifluoroethyl, trifluoromethyl, and trifluoromethoxy.

[0053] In an embodiment of each aspect of the invention, the compound of formula (I) is R 1 As Cyano, R2 as hydrogen, R 3 as methoxymethyl, ethoxymethyl, methysulfonylmethyl, methysulfonylcyclopropyl, cyanomethyl or cyanocyclopropyl; R 4 Q is a phenyl substituted by one or two substituents independently selected from iodo, bromo, chloro, fluoro, methyl, trifluoromethyl, trifluoromethoxy, trifluoromethylsulfanyl, cyano, and methylsulfonyl, or any of thiophenyl, pyridyl (or pyridinyl), and pyrazolyl, each of which is substituted by one to three substituents independently selected from fluorine, chlorine, methyl, ethyl, isopropyl, trifluoromethyl, difluoromethyl, trifluoromethoxy, and difluoromethoxy; Q is a cyclic amine represented by formula IIa (wherein, p 1 and p 2 are both 1, X is hydrogen; and Y is selected from the group consisting of cyano, C1-C2-alkylsulfanyl-C1-C2-alkyl, C1-C2-alkylsulfinyl-C1-C2-alkyl, C1-C2-alkylsulfonyl-C1-C2-alkyl, 1,1-dioxo-1,2-thiazolidin-2-yl, N,N-di(C1-C2-alkyl)carboxamido, C1-C2-alkoxy-imino-C1-C2-alkyl, C1-C2-alkylsulfonylamido, phenyl, chloro, methyl , phenyl substituted with 1 to 3 substituents independently selected from difluoromethyl, trifluoromethyl, and trifluoromethoxy, or a 5- or 6-membered monocyclic heteroaryl selected from 1,2,4-oxadiazol-3-yl, pyridin-2-yl, and 1,2,4-triazol-3-yl, wherein each heteroaryl is substituted with 1 to 3 substituents independently selected from chloro, fluoro, methyl, trifluoromethyl, and trifluoromethoxy.

[0054] In an embodiment of each aspect of the invention, the compound of formula (I) is R 1 As Cyano, R 2as hydrogen, R 3 as methoxymethyl; R 4 Q is a phenyl substituted with a substituent selected from chloro, fluoro, and trifluoromethyl; Q is a cyclic amine represented by formula IIa (wherein p 1 and p 2 are both 1, X is hydrogen; and Y is a 5- or 6-membered monocyclic heteroaryl selected from 1,2,4-oxadiazol-3-yl, pyridin-2-yl, and 1,2,4-triazol-3-yl, wherein each heteroaryl is substituted with 1 to 3 substituents independently selected from chloro, fluoro, methyl, trifluoromethyl, and trifluoromethoxy.

[0055] In an embodiment of each aspect of the invention, the compound of formula (I) is R 1 as cyano or C(=S)NH2, R 2 as hydrogen, R 3 R is selected from methoxymethyl, ethoxymethyl, methysulfonylmethyl, methysulfonylcyclopropyl, cyanomethyl and cyanocyclopropyl; 4 Q is any one of phenyl substituted by 1 or 2 substituents independently selected from halogen, C1-C4-alkyl, C1-C4-haloalkyl, cyano, C1-C4-haloalkylsulfanyl, C1-C4-alkylsulfonyl and C1-C4-haloalkoxy, thiophenyl, pyridyl (or pyridinyl) and pyrazolyl, each of which is substituted by 1 to 2 substituents independently selected from halogen, C1-C4-alkyl, C1-C4-haloalkyl and C1-C4-haloalkoxy; Q is a cyclic amine represented by formula IIb (wherein p 1 and p 2are both 1 and A is cyano, C1-C4-cyanoalkyl, C1-C4-haloalkyl, C1-C4-alkylsulfanyl-C1-C4-alkyl, C1-C4-alkylsulfinyl-C1-C4-alkyl, C1-C4-alkylsulfonyl-C1-C4-alkyl, C1-C4-alkoxycarbonyl, C2-C4-alkenyloxycarbonyl, phenyl, phenyl substituted with 1 to 3 substituents independently selected from halogen, C1-C3-alkyl and C1-C3-haloalkyl and C1-C3-haloalkoxy, or 5- or 6-membered monocyclic heteroaryl substituted with 1 to 3 substituents independently selected from halogen, C1-C3-alkyl and C1-C3-haloalkyl and C1-C3-haloalkoxy).

[0056] In an embodiment of each aspect of the invention, the compound of formula (I) is R 1 as cyano or C(=S)NH2, R 2 as hydrogen, R 3 R is selected from methoxymethyl, ethoxymethyl, methysulfonylmethyl, methysulfonylcyclopropyl, cyanomethyl and cyanocyclopropyl; 4 Q is a phenyl substituted with one or two substituents independently selected from iodo, bromo, chloro, fluoro, methyl, trifluoromethyl, trifluoromethoxy, trifluoromethylsulfanyl, cyano, and methylsulfonyl; Q is a cyclic amine represented by formula IIb (wherein p 1 and p 2are both 1 and A is cyano, C1-C4-cyanoalkyl, C1-C4-haloalkyl, C1-C4-alkylsulfanyl-C1-C4-alkyl, C1-C4-alkylsulfinyl-C1-C4-alkyl, C1-C4-alkylsulfonyl-C1-C4-alkyl, C1-C4-alkoxycarbonyl, C2-C4-alkenyloxycarbonyl, phenyl, phenyl substituted with 1 to 3 substituents independently selected from halogen, C1-C3-alkyl and C1-C3-haloalkyl and C1-C3-haloalkoxy, or 5- or 6-membered monocyclic heteroaryl substituted with 1 to 3 substituents independently selected from halogen, C1-C3-alkyl and C1-C3-haloalkyl and C1-C3-haloalkoxy).

[0057] In an embodiment of each aspect of the invention, the compound of formula (I) is R 1 as cyano or C(=S)NH2, R 2 as hydrogen, R 3 R is selected from methoxymethyl, ethoxymethyl, methysulfonylmethyl, methysulfonylcyclopropyl, cyanomethyl and cyanocyclopropyl; 4 Q is a phenyl substituted with one or two substituents independently selected from iodo, bromo, chloro, fluoro, methyl, trifluoromethyl, trifluoromethoxy, trifluoromethylsulfanyl, cyano, and methylsulfonyl; Q is a cyclic amine represented by formula IIb (wherein p 1 and p 2are both 1 and A is cyano, C1-C4-cyanoalkyl, C1-C4-haloalkyl, C1-C4-alkylsulfanyl-C1-C4-alkyl, C1-C4-alkylsulfinyl-C1-C4-alkyl, C1-C4-alkylsulfonyl-C1-C4-alkyl, C1-C4-alkoxycarbonyl, C2-C4-alkenyloxycarbonyl, phenyl, phenyl substituted with 1 to 3 substituents independently selected from chloro, methyl, difluoromethyl, trifluoromethyl and trifluoromethoxy, or 5- or 6-membered monocyclic heteroaryl substituted with 1 to 3 substituents independently selected from chloro, methyl, difluoromethyl, trifluoromethyl and trifluoromethoxy).

[0058] In an embodiment of each aspect of the invention, the compound of formula (I) is R 1 as cyano or C(=S)NH2, R 2 as hydrogen, R 3 R is selected from methoxymethyl, ethoxymethyl, methysulfonylmethyl, methysulfonylcyclopropyl, cyanomethyl and cyanocyclopropyl; 4 Q is a phenyl substituted with one or two substituents independently selected from iodo, bromo, chloro, fluoro, methyl, trifluoromethyl, trifluoromethoxy, trifluoromethylsulfanyl, cyano, and methylsulfonyl; Q is a cyclic amine represented by formula IIb (wherein p 1 and p 2 are both 1 and A is pyridyl substituted with 1 to 3 substituents independently selected from chloro, fluoro, methyl, difluoromethyl, trifluoromethyl, and trifluoromethoxy.

[0059] In an embodiment of each aspect of the invention, the compound of formula (I) is R 1 as cyano or C(=S)NH2, R 2 as hydrogen, R 3R is selected from methoxymethyl, ethoxymethyl, methysulfonylmethyl, methysulfonylcyclopropyl, cyanomethyl and cyanocyclopropyl; 4 Q is a phenyl substituted with one or two substituents independently selected from iodo, bromo, chloro, fluoro, methyl, trifluoromethyl, trifluoromethoxy, trifluoromethylsulfanyl, cyano, and methylsulfonyl; Q is a cyclic amine represented by formula IIb (wherein p 1 and p 2 are both 1 and A is pyridyl substituted with 1 to 3 substituents independently selected from chloro, fluoro, trifluoromethyl, and trifluoromethoxy.

[0060] In an embodiment of each aspect of the invention, the compound of formula (I) is R 1 Cyano as R 2 as hydrogen; R 3 R is selected from methoxymethyl, ethoxymethyl, methysulfonylmethyl, methysulfonylcyclopropyl, cyanomethyl and cyanocyclopropyl; 4 as halogen, C1-C3-alkyl, C1-C3-haloalkyl, C1-C3-haloalkoxy and -OC 1-2 haloalkanediyl-O- substituted phenyl; Q is a cyclic amine represented by formula IIa (wherein p 1 and p 2 are both 1, X is hydrogen; and Y is a 5- or 6-membered monocyclic heteroaryl or one to three independently selected substituents R 9 is a 5- or 6-membered monocyclic heteroaryl substituted with

[0061] In an embodiment of each aspect of the invention, the compound of formula (I) is R 1 Cyano as R2 as hydrogen; R 3 R is selected from methoxymethyl, ethoxymethyl, methysulfonylmethyl, methysulfonylcyclopropyl, cyanomethyl and cyanocyclopropyl; 4 Examples of the alkyl group include halogen, C1-C3-alkyl, C1-C3-haloalkyl, C1-C3-alkoxy, C1-C3-alkylsulfonyl, C1-C3-haloalkylsulfanyl, cyano, C1-C3-haloalkoxy, and -OC. 1-2 haloalkanediyl-O-; Q is a cyclic amine represented by formula IIa, wherein p1 and p2 are both 1 and X is hydrogen; and Y is a cyclic amine represented by formula IIa, wherein p1 and p2 are both 1 and X is hydrogen; and Y is a cyclic amine represented by formula IIa, wherein p1 and p2 are both 1 and X is hydrogen; 9 substituted oxadiazolyl).

[0062] In an embodiment of each aspect of the invention, the compound of formula (I) is R 1 Cyano as R 2 as hydrogen; R 3 R is selected from methoxymethyl, ethoxymethyl, methysulfonylmethyl, methysulfonylcyclopropyl, cyanomethyl and cyanocyclopropyl; 4 as halogen, C1-C3-haloalkyl, C1-C3-haloalkoxy and -OC 1-2 haloalkanediyl-O- substituted with phenyl; Q is a cyclic amine represented by formula IIa (wherein p1 and p2 are both 1, X is hydrogen; and Y is 1,2,4-oxadiazol-3-yl substituted with 1 to 2 substituents independently selected from methyl, ethyl, and isopropyl).

[0063] In an embodiment of each aspect of the invention, the compound of formula (I) is R 1Cyano as R 2 as hydrogen; R 3 R is selected from methoxymethyl, ethoxymethyl, methysulfonylmethyl, methysulfonylcyclopropyl, cyanomethyl and cyanocyclopropyl; 4 as halogen, C1-C3-haloalkyl, C1-C3-haloalkoxy and -OC 1-2 haloalkanediyl-O-, wherein Q is a cyclic amine represented by formula IIb (wherein q1 and q2 are both 1, and A is pyridyl substituted with 1 to 3 independently selected halogen substituents).

[0064] In an embodiment of each aspect of the invention, the compound of formula (I) is R 1 Cyano as R 2 as hydrogen; R 3 R is selected from methoxymethyl, ethoxymethyl, methysulfonylmethyl, methysulfonylcyclopropyl, cyanomethyl and cyanocyclopropyl; 4 as halogen, C1-C3-haloalkyl, C1-C3-haloalkoxy and -OC 1-2 haloalkanediyl-O- phenyl substituted with 1 or 2 substituents independently selected from; Q is a cyclic amine represented by formula IIb (wherein q1 and q2 are both 1, and A is pyridyl substituted with 1 to 2 substituents independently selected from chlorine, fluorine, and bromine).

[0065] In one embodiment of each aspect of the invention, the compound of formula (I) is R 1 As the cyano group, R 2 R has hydrogen; 3 R 4as Q, a phenyl substituted with one or two substituents independently selected from halogen, C1-C3 haloalkyl, and C1-C3 haloalkoxy; Q, a cyclic amine represented by formula IIa, wherein p1 and p2 are both 1 and X is hydrogen; and Y, a C1-C3 alkoxymethyl, C1-C3 alkoxyN=CH—, C1-C3 alkylsulfanylmethyl, C1-C3 alkylsulfinylmethyl, C1-C3 alkylsulfonylmethyl, -1,1-dioxo-thiazolidinyl, 1-methylpyrazolyl, C1-C3 alkylsulfonyl-C1-C3 alkylamino, methyl-1,2,4-oxadiazolyl, or methylisoxazolyl.

[0066] In one embodiment of each aspect of the invention, the compound of formula (I) is R 1 As the cyano group, R 2 R has hydrogen; 3 R 4 as Q, a phenyl substituted with one or two substituents independently selected from halogen, C1-C3 haloalkyl, and C1-C3 haloalkoxy; Q, a cyclic amine represented by formula IIa, where p1 and p2 are both 1 and X is hydrogen; and Y, is -CH2SCH2CH3; -CH2S(=O)CH2CH3, -CH2SO2CH2CH3, 1,1-dioxo-1,2-thiazolidin-2-yl, 1-methylpyrazol-4-yl, methyl(methylsulfonyl)-amino (i.e., CH3S(O)2-(CH3)N-, 3-methyl-1,2,4-oxadiazol-5-yl, 1-methylpyrazol-3-yl, or 3-methylisoxazol-5-yl.

[0067] In an embodiment of each aspect of the invention, the compound of formula (I) is R 1 Cyano as R 2 as hydrogen; R 3 as methoxymethyl; R 4wherein Q is one of 2,1,3-benzoxadiazolyl, 1,3-benzoxazolyl, thiophenyl, pyridyl (or pyridinyl), and pyrazolyl (each unsubstituted or substituted with 1 to 3 substituents independently selected from halogen, C1-C4-alkyl, C1-C4-haloalkyl, and C1-C4-haloalkoxy); and Q is a cyclic amine represented by formula IIa (wherein p1 and p2 are both 1, X is hydrogen; and Y is 1,2,4-oxadiazol-3-yl substituted with 1 to 2 substituents independently selected from methyl, ethyl, and isopropyl).

[0068] In one embodiment of each aspect of the invention, the compound of formula (I) is R 1 As the cyano group, R 2 R has hydrogen; 3 R 4 as Q, a cyclic amine represented by formula IIa, wherein p1 and p2 are both 1 and X is hydrogen; and Y is 5-methyl-1,2,4-oxadiazol-3-yl.

[0069] In one embodiment of each aspect of the invention, the compound of formula (I) is R 1 as cyano or C(=S)NH; R 2 R has hydrogen; 3 R 4 as Q, a cyclic amine represented by formula IIa, wherein p1 and p2 are both 1 and X is hydrogen; and Y is 1,2,4-oxadiazol-3-yl substituted with 1 to 2 substituents independently selected from methyl, ethyl, and isopropyl.

[0070] In one embodiment of each aspect of the invention, the compound of formula (I) is R 1 as cyano or C(=S)NH; R 2 R has hydrogen; 3 R 4 as Q, a cyclic amine represented by formula IIa, wherein p1 and p2 are both 1, X is hydrogen; and Y is 5-methyl-1,2,4-oxadiazol-3-yl.

[0071] In an embodiment of each aspect of the invention, the compound of formula (I) is R 1 Cyano as R 2 as hydrogen; R 3 as methoxymethyl; R 4 as phenyl, thiophenyl, pyridyl (or pyridinyl) and pyrazolyl, each of which is selected from halogen, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-haloalkoxy and -OC 1-2 haloalkanediyl-O- substituted with 1 to 3 substituents independently selected from: haloalkanediyl-O-; and Q is a cyclic amine represented by formula IIa (wherein p1 and p2 are both 1, X is hydrogen; and Y is a C1-C3-alkyl substituted 1,2,4-triazolyl).

[0072] In an embodiment of each aspect of the invention, the compound of formula (I) is R 1 Cyano as R 2 as hydrogen; R 3 as methoxymethyl; R 4 as phenyl, thiophenyl, pyridyl (or pyridinyl) and pyrazolyl, each of which is selected from halogen, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-haloalkoxy and -OC 1-2haloalkanediyl-O-; and Q is a cyclic amine represented by formula IIa (wherein p1 and p2 are both 1, X is hydrogen; and Y is 1-methyl-1,2,4-triazol-3-yl).

[0073] In one embodiment of each aspect of the invention, the compound of formula (I) is R 1 As the cyano group, R 2 R has hydrogen; 3 R 4 as Q, a phenyl substituted with one or two substituents independently selected from halogen, and C1-C3 haloalkyl; and as Q, a cyclic amine represented by formula IIb, wherein q1 and q2 are both 1, and A is C1-C3 alkylamino-sulfonyl, di(C1-C3 alkyl)amino-sulfonyl, pyrazol-3-yl, or oxadiazolyl.

[0074] In one embodiment of each aspect of the invention, the compound of formula (I) is R 1 As the cyano group, R 2 R has hydrogen; 3 R 4 as Q, a phenyl substituted with one or two substituents independently selected from fluorine and trifluoromethyl; and as Q, a cyclic amine represented by formula IIb, wherein q1 and q2 are both 1, and A is methylamino-sulfonyl, dimethylamino-sulfonyl, 1-methylpyrazol-3-yl, 5-methyl-1,2,4-oxadiazol-3-yl, or 3-methyl-1,2,4-oxadiazol-5-yl.

[0075] In an embodiment of each aspect of the invention, the compound of formula (I) is R 1 Cyano as R 2 as hydrogen; R 3as methoxymethyl, ethoxymethyl, methysulfonylmethyl, methysulfonylcyclopropyl, cyano-methyl and cyano-cyclopropyl; R 4 as halogen, C1-C3-haloalkyl, C1-C3-haloalkoxy and -OC 1-2 haloalkanediyl-O- phenyl substituted by 1 or 2 substituents independently selected from; and Q is a cyclic amine represented by formula IIa (wherein q1 and q2 are both 1, X is hydrogen, and Y is methoxymethyl, ethylsulfanylmethyl, ethylsulfinylmethyl, ethylsulfonylmethyl, 1-methyl-1,2,4-triazol-3-yl, 1,1-dioxo-1,2-thiazolidin-2-yl, 1-methylpyrazol-3-yl, 5-methyl-1,1-dioxo-1,2,5-thiadiazolidin-2-yl, or 5-ethyl-1,1-dioxo-1,2,5-thiadiazolidin-2-yl).

[0076] In an embodiment of each aspect of the invention, the compound of formula (I) is R 1 Cyano as R 2 as hydrogen; R 3 as methoxymethyl; R 4 as halogen, C1-C3-haloalkyl, C1-C3-haloalkoxy and -OC 1-2 haloalkanediyl-O- phenyl substituted by 1 or 2 substituents independently selected from; and Q is a cyclic amine represented by formula IIa (wherein q1 and q2 are both 1, X is hydrogen, and Y is methoxymethyl, ethylsulfanylmethyl, ethylsulfinylmethyl, ethylsulfonylmethyl, 1-methyl-1,2,4-triazol-3-yl, 1,1-dioxo-1,2-thiazolidin-2-yl, 1-methylpyrazol-3-yl, 5-methyl-1,1-dioxo-1,2,5-thiadiazolidin-2-yl, or 5-ethyl-1,1-dioxo-1,2,5-thiadiazolidin-2-yl).

[0077] In an embodiment of each aspect of the invention, the compound of formula (I) is R 1 Cyano as R 2 as hydrogen; R 3 as methoxymethyl; R 4 as halogen, C1-C3-haloalkyl, C1-C3-haloalkoxy and -OC 1-2 haloalkanediyl-O- substituted phenyl; and Q is a cyclic amine represented by formula IIa, wherein q1 and q2 are both 1, X is hydrogen, and Y is 1,1-dioxo-1,2-thiazolidin-2-yl, 5-methyl-1,1-dioxo-1,2,5-thiadiazolidin-2-yl, or 5-ethyl-1,1-dioxo-1,2,5-thiadiazolidin-2-yl.

[0078] In an embodiment of each aspect of the invention, the compound of formula (I) is R 1 Cyano as R 2 as hydrogen; R 3 as methoxymethyl, ethoxymethyl, methysulfonylmethyl, methysulfonylcyclopropyl, cyano-methyl and cyano-cyclopropyl; R 4 as halogen, C1-C3-haloalkyl, C1-C3-haloalkoxy and -OC 1-2 haloalkanediyl-O- phenyl substituted by 1 or 2 substituents independently selected from; and Q is a cyclic amine represented by formula IIb, wherein q1 and q2 are both 1, and A is ethylsulfonyl, propylsulfonyl, isopropylsulfonyl, cyclopropylsulfonyl, methylsulfamoyl, ethylsulfamoyl, dimethylsulfamoyl, ethyl(methyl)sulfamoyl, 4-fluoro-phenyl, 3,5-dichloropyridin-2-yl, 4-fluoro-pyridin-2-yl, 5-methyl-1,2,4-oxadiazol-3-yl, 3-methyl-1,2,4-oxadiazol-5-yl, or 1-methylpyrazol-3-yl.

[0079] In an embodiment of each aspect of the invention, the compound of formula (I) is R 1 Cyano as R 2 as hydrogen; R 3 as methoxymethyl; R 4 as halogen, C1-C3-haloalkyl, C1-C3-haloalkoxy and -OC 1-2 haloalkanediyl-O- phenyl substituted by 1 or 2 substituents independently selected from; and Q is a cyclic amine represented by formula IIb, wherein q1 and q2 are both 1, and A is ethylsulfonyl, propylsulfonyl, isopropylsulfonyl, cyclopropylsulfonyl, methylsulfamoyl, ethylsulfamoyl, dimethylsulfamoyl, ethyl(methyl)sulfamoyl, 4-fluoro-phenyl, 3,5-dichloropyridin-2-yl, 4-fluoro-pyridin-2-yl, 5-methyl-1,2,4-oxadiazol-3-yl, 3-methyl-1,2,4-oxadiazol-5-yl, or 1-methylpyrazol-3-yl.

[0080] In an embodiment of each aspect of the invention, the compound of formula (I) is R 1 Cyano as R 2 as hydrogen; R 3 as methoxymethyl; R 4 as Q, a phenyl substituted with 1 to 2 substituents independently selected from halogen and C1-C4-haloalkyl; and Q, a cyclic amine represented by formula IIa, wherein p1 and p2 are both 1, X is hydroxyl, and Y is phenyl disubstituted with 1 to 2 halogens.

[0081] In an embodiment of each aspect of the invention, the compound of formula (I) is R 1 Cyano as R 2 as hydrogen; R 3 as methoxymethyl; R 4as Q, a phenyl substituted with 1 to 2 substituents independently selected from fluorine and trifluoromethyl; and Q, a cyclic amine represented by formula IIa, wherein p1 and p2 are both 1, X is hydroxyl, and Y is a chloro-substituted phenyl.

[0082] In one embodiment of each aspect of the invention, the compound of formula (I) is R 1 As the cyano group, R 2 R has hydrogen; 3 R 4 as Q, a cyclic amine represented by formula IIa, wherein p1 and p2 are both 0 and X is hydrogen; and Y is C1-C3 alkylsulfanylmethyl, C1-C3 alkylsulfonylmethyl, or oxadiazolyl.

[0083] In one embodiment of each aspect of the invention, the compound of formula (I) is R 1 As the cyano group, R 2 R has hydrogen; 3 R 4 as Q, a cyclic amine represented by formula IIa, wherein p1 and p2 are both 0, X is hydrogen; and Y is n-propylsulfonylmethyl.

[0084] In a second aspect, the present invention makes available a composition comprising a compound of formula (I) as defined in the first aspect, one or more adjuvants and diluents and optionally one or more other active ingredients.

[0085] In a third aspect, the present invention makes available a method for combating and controlling insects, acaridae, nematodes or molluscs, which comprises applying to the pest, the pest's habitat or plants susceptible to attack by the pest an insecticidally, acaricidally, nematicidally or molluscicidally effective amount of a compound as defined in the first aspect or a composition as defined in the second aspect.

[0086] In a fourth aspect, the present invention makes available a method for the protection of plant propagation material from attack by insects, mites, nematodes or mollusks, which comprises treating the propagation material or the locus in which the propagation material is planted with an effective amount of a compound of formula (I) as defined in the first aspect or a composition as defined in the second aspect.

[0087] In a fifth aspect, the present invention makes available plant propagation material, such as seeds, which comprises, has been treated with or has attached thereto a compound of formula (I) as defined in the first aspect or a composition as defined in the second aspect.

[0088] In a further aspect, the present invention provides a method of controlling parasites in or on an animal in need thereof, the method comprising administering an effective amount of a compound of formula (I) as defined in the first aspect. The present invention further provides a method of controlling ectoparasites on an animal in need thereof, the method comprising administering an effective amount of a compound of the first aspect. The present invention further provides a method of preventing and / or treating diseases transmitted by ectoparasites, the method comprising administering to an animal in need thereof an effective amount of a compound of formula (I) as defined in the first aspect.

[0089] Compounds of formula (I) can be prepared by those skilled in the art by following known methods. More specifically, compounds and intermediates of formulas I and I'a can be prepared as described below in the schemes and examples. The specific stereogenic centers are left unspecified for the sake of brevity and are not intended to limit the teachings of the schemes in any way.

[0090] The processes for preparing the compounds of formula (I) according to the invention are carried out by methods known to those skilled in the art.

[0091] Compounds of formula (I) are novel and can be prepared according to Scheme 1 by the coupling of known amide coupling reagents, such as 1-[bis(dimethylamino)-methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide hexafluorophosphate (HATU) and a base, such as Hunig's base, in a suitable solvent, such as dimethylformamide (DMF) or dimethylacetamide (DMA), to give acids III (wherein R 1 , R 2 , R 3 , and R 4 are as defined above) with an amine IV-a or IV-b (where X, Y, A, p 1 , p 2 , q 1 and q 2 is as defined above). Piperidines IV-a or piperazines IV-b are commercially available, known from the literature, or can be prepared by one skilled in the art. Scheme 1: [ka]

[0092] Alternatively, compounds of formula (I) can be prepared according to Scheme 2 by the reaction of an acid chloride V (where R 1 , R 2 , R3 , and R 4 are as defined above) with an amine IV-a or IV-b (where X, Y, A, p 1 , p 2 , q 1 and q 2 can be prepared by reacting Scheme 2: [ka]

[0093] R 1 , R 2 , R 3 and R 4 Acid chlorides V, wherein R is as previously defined, can be converted to R by treatment with, for example, oxalyl chloride or thionyl chloride in the presence of a catalytic amount of DMF in an inert solvent such as DCM or THF at a temperature between 20° C. and 100° C., preferably 25° C., according to Scheme 3. 1 , R 2 , R 3 and R 4 can be prepared from the corresponding acid III, where Scheme 3: [ka]

[0094] R 1 , R 2 , R 3 and R 4 Acids III, where R is as previously defined, can be converted to R according to Scheme 4 under basic conditions, for example using an inorganic base such as lithium hydroxide, sodium hydroxide, potassium hydroxide or potassium carbonate in water, methanol, ethanol or THF. 1 , R 2 , R 3 and R 4 is as previously defined, and R x It can be prepared by hydrolysis of the corresponding ester VI, where =C1-C6-alkyl. Scheme 4: [ka]

[0095] R 1 , R 2 , R 3 and R 4 Esters VI, where R is as previously defined, can be prepared by the reaction of R according to Scheme 5 in the presence of a base, for example an inorganic base such as lithium hydroxide, sodium hydroxide, potassium hydroxide or potassium carbonate, and a suitable solvent, for example water, methanol, ethanol, acetone, THF, DMF or toluene. 1 , R 2 , R 3 , R 4 and R x wherein R is as previously defined, and 4 is as previously defined, and LG 1 is a leaving group such as halogen, e.g., bromine, chlorine, iodine, or mesylate. It may be advantageous to add sodium iodide or a phase transfer catalyst such as tetrabutylammonium bromide or tetrabutylammonium iodide. Scheme 5: [ka]

[0096] Alternatively, esters VI can be converted to R 2 according to Scheme 6 in the presence of a base such as sodium hydride, lithium hydroxide, sodium hydroxide, potassium hydroxide or potassium carbonate and a suitable solvent such as THF, DMF or toluene. 1 , R 2 , R 3 , R x is as previously defined, and LG 2 They can be prepared by reacting a pyridine IX, where X is a leaving group such as halogen, for example fluorine, bromine, chlorine, iodine or mesylate, with an alcohol X. Scheme 6: [ka]

[0097] Alternatively, compounds of formula (I) can be prepared by the reaction of R 1 , R 2 , R 3 and Q are as previously defined, and R4 are as previously defined, and LG 1 can be prepared by reaction with alkylating reagent VIII, which is a leaving group such as a halogen, e.g., bromine, chlorine, iodine, or mesylate. It may be advantageous to add sodium iodide or a phase transfer catalyst, e.g., tetrabutylammonium bromide or tetrabutylammonium iodide. Scheme 7: [ka]

[0098] Alternatively, compounds of formula (I) can be prepared by reacting R 1 , R 2 , R 3 and Q are as previously defined, and LG 2 These can be prepared by reacting a pyridine XII, where X is a leaving group such as halogen, for example fluorine, bromine, chlorine, iodine or mesylate, with an alcohol X. Scheme 8: [ka]

[0099] A compound of formula XII, where R 1 , R 2 , R 3 and Q are as defined above, and LG 2 is a leaving group) can be converted to pyridone XI (where R 1 , R 2 , R 3 and Q is as defined above) can be obtained by treating with a halogenating reagent such as phosphorus oxychloride or oxalyl chloride or mesyl chloride. Scheme 9: [ka]

[0100] Pyridone XI (where R 1 , R 2 , R 3 and Q are as defined above) can be converted to acids XIII (where R 1 , R 2 and R 3 are as defined above) with an amine IV-a or IV-b (where X, Y, A, p 1 , p 2 , q 1 and q 2 can be prepared by reacting Scheme 10: [ka]

[0101] Alternatively, a compound of formula XI (where R 1 , R 2 , R 3and Q are as defined above) can be converted to an acid chloride XIV (where R 1 , R 2 and R 3 is as defined above) with an amine IV-a or IV-b. Scheme 11: [ka]

[0102] Acid chloride XIV (where R 1 , R 2 and R 3 is as defined above) can be converted to the corresponding acid XIII (where R is as defined above) by treatment with, for example, oxalyl chloride or thionyl chloride in an inert solvent such as DCM or THF in the presence of a catalytic amount of DMF at a temperature between 20° C. and 100° C., preferably 25° C., according to Scheme 12. 1 , R 2 and R 3 can be prepared from Scheme 12: [ka]

[0103] Acid XIII (wherein R 1 , R 2 and R 3 is as defined above) can be converted to the corresponding ester XV (where R 1 , R 2 , R 3 and R x can be prepared by hydrolysis of an ester of formula XV (where R 1, R 2 , R 3 and R x is as defined above) are known in the literature, for example, Y. Xie et al., Pest Manag. Sci. 2017, 73, 945-952, or can be prepared by a person skilled in the art. Scheme 13: [ka]

[0104] The compounds of formula (I) according to the following Tables 1 to 81 can be prepared according to the above methods. The following examples are intended to illustrate the present invention and to show preferred compounds of formula (I) in the form of compounds of formula (Ia). [ka]

[0105] Each of Tables 1 to 48 following Table M below consists of 1316 compounds of formula (Ia), wherein R 1 , R 3 , and R 5 has the value shown in each row in Table M, and Y and X have the values ​​shown in the associated Tables 1-48.

[0106] Thus, compound 1.1 corresponds to a compound of formula (Ia), where R 1 , R 3 , and R 5 is as defined in row 1 of Table M, Y and X are as defined in Table 1; compound 14.14 corresponds to the compound of formula (Ia), where R 1 , R 3 , and R 5 is as defined in row 14 of Table M, Y and X are as defined in Table 14, etc.

[0107] [Table 1-1]

Table 1-2

Table 1-3

Table 1-4

Table 1-5

Table 1-6

Table 1-7

Table 1-8

Table 1-9

Table 1-10

Table 1-11

Table 1-12

Table 1-13

Table 1-14

Table 1-15

Table 1-16

Table 1-17

Table 1-18

Table 1-19

Table 1-20

Table 1-21

Table 1-22

Table 1-23

Table 1-24

Table 1-25

Table 1-26

Table 1-27

Table 1-28

Table 1-29

Table 1-30

Table 1-31

Table 1-32

Table 1-33

Table 1-34

[0108] Table 1: This table shows compounds where Y is 5-methyl-1,2,4-oxadiazol-3-yl, X is hydrogen, and R 1 , R 3 and R 5 discloses 1,316 compounds of formula (Ia), 1.1 to 1.1316, as defined in Table M. For example, compound number 1.1 has the following structure: [ka]

[0109] Table 2: This table shows compounds where Y is 1-methyl-1,2,4-triazol-3-yl, X is hydrogen, and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ia), 2.1 to 2.1316, as defined in Table M.

[0110] Table 3: This table shows compounds where Y is 3,5-dichloropyridin-2-yl, X is hydrogen, and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ia), 3.1 to 3.1316, as defined in Table M.

[0111] Table 4: This table shows compounds where Y is 3-chloro-5-(trifluoromethyl)pyridin-2-yl, X is hydrogen, and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ia), 4.1 to 4.1316, as defined in Table M.

[0112] Table 5: This table shows compounds where Y is 4-chloro-phenyl-1-yl, X is hydrogen, and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ia), 5.1 to 5.1316, as defined in Table M.

[0113] Table 6: This table shows compounds where Y is 4-chloro-phenyl-1-yl, X is hydroxyl, and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ia), 6.1 to 6.1316, as defined in Table M.

[0114] Table 7: This table shows compounds where Y is methylsulfanylmethyl, X is hydrogen, and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ia) 7.1 to 7.1316, as defined in Table M.

[0115] Table 8: This table shows compounds where Y is methylsulfinylmethyl, X is hydrogen, and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ia), 8.1 to 8.1316, as defined in Table M.

[0116] Table 9: This table shows compounds where Y is methylsulfonylmethyl, X is hydrogen, and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ia), 9.1 to 9.1316, as defined in Table M.

[0117] Table 10: This table shows compounds where Y is ethylsulfanylmethyl, X is hydrogen, and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ia), 10.1 to 10.1316, as defined in Table M.

[0118] Table 11: This table shows compounds where Y is ethylsulfinylmethyl, X is hydrogen, and R 1 , R 3 and R 5discloses 1316 compounds of formula (Ia), 11.1 to 11.1316, as defined in Table M.

[0119] Table 12: This table shows compounds where Y is ethylsulfonylmethyl, X is hydrogen, and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ia), 12.1 to 12.1316, as defined in Table M.

[0120] Table 13: This table lists compounds in which Y is 1,1-dioxo-1,2-thiazolidin-2-yl, X is hydrogen, and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ia), 13.1 to 13.1316, as defined in Table M.

[0121] Table 14: This table shows compounds where Y is dimethylcarbamoyl, X is hydrogen, and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ia), 14.1 to 14.1316, as defined in Table M.

[0122] Table 15: This table shows compounds where Y is methanesulfonamide, X is hydrogen, and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ia), 15.1 to 15.1316, as defined in Table M.

[0123] Table 16: This table shows compounds where Y is ethoxymethyl, X is hydrogen, and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ia), 16.1 to 16.1316, as defined in Table M.

[0124] Table 17: This table shows compounds where Y is methoxyethyl, X is hydrogen, and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ia), 17.1 to 17.1316, as defined in Table M.

[0125] Table 18: This table shows compounds in which Y is 2-methyl-1,2,4-triazol-3-yl, X is hydrogen, and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ia), 18.1 to 18.1316, as defined in Table M.

[0126] Table 19: This table shows compounds where Y is 1-methylpyrazol-4-yl, X is hydrogen, and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ia), 19.1 to 19.1316, as defined in Table M.

[0127] Table 20: This table shows compounds in which Y is 4-methylpyrazol-1-yl, X is hydrogen, and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ia), 20.1 to 20.1316, as defined in Table M.

[0128] Table 21: This table shows compounds in which Y is 3-methyl-1,2,4-oxadiazol-5-yl, X is hydrogen, and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ia), 21.1 to 21.1316, as defined in Table M.

[0129] Table 22: This table shows compounds in which Y is 1-methylpyrazol-3-yl, X is hydrogen, and R 1 , R 3 and R 5discloses 1316 compounds of formula (Ia), 22.1 to 22.1316, as defined in Table M.

[0130] Table 23: This table shows compounds where Y is 3-methylisoxazol-5-yl, X is hydrogen, and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ia), 23.1 to 23.1316, as defined in Table M.

[0131] Table 24: This table shows compounds in which Y is 2-oxooxazolidin-3-yl, X is hydrogen, and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ia), 24.1 to 24.1316, as defined in Table M.

[0132] Table 25: This table shows compounds in which Y is 2-oxopyrrolidin-1-yl, X is hydrogen, and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ia), 25.1 to 25.1316, as defined in Table M.

[0133] Table 26: This table shows compounds in which Y is 1,2,3-triazol-2-yl, X is hydrogen, and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ia), 26.1 to 26.1316, as defined in Table M.

[0134] Table 27: This table shows compounds in which Y is 1,2,4-triazol-3-yl, X is hydrogen, and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ia), 27.1 to 27.1316, as defined in Table M.

[0135] Table 28: This table shows compounds in which Y is 2-oxo-5,5-dimethyl-oxazolidin-3-yl, X is hydrogen, and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ia), 28.1 to 28.1316, as defined in Table M.

[0136] Table 29: This table shows compounds where Y is methylamino-carbonyl, X is hydrogen, and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ia), 29.1 to 29.1316, as defined in Table M.

[0137] Table 30: This table shows compounds in which Y is 2-oxopiperidin-1-yl, X is hydrogen, and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ia), 30.1 to 30.1316, as defined in Table M.

[0138] Table 31: This table shows compounds where Y is acetamide, X is hydrogen, and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ia), 31.1 to 31.1316, as defined in Table M.

[0139] Table 32: This table shows compounds in which Y is 2-methylpropanoylamino, X is hydrogen, and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ia), 32.1 to 32.1316, as defined in Table M.

[0140] Table 33: This table lists compounds in which Y is 1,2,3-triazol-1-yl, X is hydrogen, and R 1 , R 3 and R 5discloses 1316 compounds of formula (Ia), 33.1 to 33.1316, as defined in Table M.

[0141] Table 34: This table shows compounds in which Y is 5-methylisoxazol-3-yl, X is hydrogen, and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ia), 34.1 to 34.1316, as defined in Table M.

[0142] Table 35: This table shows compounds in which Y is 2-oxoazetidin-1-yl, X is hydrogen, and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ia), 35.1 to 35.1316, as defined in Table M.

[0143] Table 36: This table shows compounds in which Y is 3-methylpyrazol-1-yl, X is hydrogen, and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ia), 36.1 to 36.1316, as defined in Table M.

[0144] Table 37: This table lists compounds in which Y is 1-methyl-5-oxo-4H-pyrazol-3-yl, X is hydrogen, and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ia), 37.1 to 37.1316, as defined in Table M.

[0145] Table 38: This table shows compounds in which Y is 3-chloro-1,2,4-triazol-1-yl, X is hydrogen, and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ia), 38.1 to 38.1316, as defined in Table M.

[0146] Table 39: This table shows compounds in which Y is 3-methyl-1,2,4-triazol-1-yl, X is hydrogen, and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ia), 39.1 to 39.1316, as defined in Table M.

[0147] Table 40: This table shows compounds in which Y is 3-methyl-5-oxo-4H-pyrazol-1-yl, X is hydrogen, and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ia), 40.1 to 40.1316, as defined in Table M.

[0148] Table 41: This table shows compounds in which Y is 3-methyl-2-oxo-imidazolidin-1-yl, X is hydrogen, and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ia), 41.1 to 41.1316, as defined in Table M.

[0149] Table 42: This table lists compounds in which Y is 5-methyl-1,1-dioxo-1,2,5-thiadiazolidin-2-yl, X is hydrogen, and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ia), 42.1 to 42.1316, as defined in Table M.

[0150] Table 43: This table lists compounds in which Y is 5-ethyl-1,1-dioxo-1,2,5-thiadiazolidin-2-yl, X is hydrogen, and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ia), 43.1 to 43.1316, as defined in Table M.

[0151] Table 44: This table shows compounds in which Y is 1,2-dimethylimidazol-4-yl, X is hydrogen, and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ia), 44.1 to 44.1316, as defined in Table M.

[0152] Table 45: This table shows compounds in which Y is 1-methylimidazol-4-yl, X is hydrogen, and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ia), 45.1 to 45.1316, as defined in Table M.

[0153] Table 46: This table shows compounds in which Y is 4-methyltriazol-1-yl, X is hydrogen, and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ia), 46.1 to 46.1316, as defined in Table M.

[0154] Table 47: This table shows compounds in which Y is 2-methyl-3-oxo-pyrazolidin-1-yl, X is hydrogen, and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ia), 47.1 to 47.1316, as defined in Table M.

[0155] Table 48: This table shows compounds in which Y is 1,2,4-triazol-4-yl, X is hydrogen, and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ia), 48.1 to 48.1316, as defined in Table M.

[0156] Specific examples of compounds of the present invention are listed in Tables 49 to 81 below, where [ka] where R 1 , R 3 and R 5 is as defined above in Table M.

[0157] The following tables 49 to 81 are 1 , R 3 and R 5 Compound 49.1 therefore comprises 1316 compounds of formula (Ib) where R has the value set forth in each row of Table M and A has the value set forth in the relevant Tables 49 to 81. 1 , R 3 and R 5 is as defined in row 1 of Table M and A corresponds to a compound of formula (Ib) where A is as defined in Table 49; compound 60.14 corresponds to a compound of formula (Ib) where R 1 , R 3 and R 5 corresponds to the compound of formula (Ib) where A is as defined in row 14 of Table M and A is as defined in Table 60, and so on.

[0158] Table 49: This table shows that A is 3,5-dichloropyridin-2-yl and R 1 , R 3 and R 5 discloses 1,316 compounds 49.1 to 49.1316 of formula (Ib), as defined in Table M. For example, compound number 55.1 has the following structure: [ka]

[0159] Table 50: This table shows compounds in which A is 3-chloro-5-(trifluoromethyl)pyridin-2-yl and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ib), 50.1 to 50.1316, as defined in Table M.

[0160] Table 51: This table shows compounds where A is 3-chloro-pyridin-2-yl and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ib), 51.1 to 51.1316, as defined in Table M.

[0161] Table 52: This table shows compounds where A is 5-fluoro-pyridin-2-yl and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ib), 52.1 to 52.1316, as defined in Table M.

[0162] Table 53: This table shows the formulas for A = cyanoethyl and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ib), 53.1 to 53.1316, as defined in Table M.

[0163] Table 54: This table shows the formulas for A = cyanopropyl and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ib), 54.1 to 54.1316, as defined in Table M.

[0164] Table 55: This table shows the compounds where A is vinyloxycarbonyl and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ib), 55.1 to 55.1316, as defined in Table M.

[0165] Table 56: This table shows that A is tert.butyloxycarbonyl and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ib), 56.1 to 56.1316, as defined in Table M.

[0166] Table 57: This table shows compounds where A is 4-fluoro-phenyl and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ib), 57.1 to 57.1316, as defined in Table M.

[0167] Table 58: This table shows that A is 4-chloro-phenyl and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ib), 58.1 to 58.1316, as defined in Table M.

[0168] Table 59: This table shows where A is ethylsulfanylmethyl and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ib), 59.1 to 59.1316, as defined in Table M.

[0169] Table 60: This table shows where A is ethylsulfinylmethyl and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ib), 60.1 to 60.1316, as defined in Table M.

[0170] Table 61: This table shows the compounds where A is ethylsulfonylmethyl and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ib), 61.1 to 61.1316, as defined in Table M.

[0171] Table 62: This table shows that A is 5-methyl-1,2,4-oxadiazol-3-yl and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ib), 62.1 to 62.1316, as defined in Table M.

[0172] Table 63: This table shows the compounds where A is 1-methylpyrazol-4-yl and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ib), 63.1 to 63.1316, as defined in Table M.

[0173] Table 64: This table shows that A is 3-methyl-1,2,4-oxadiazol-5-yl and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ib), 64.1 to 64.1316, as defined in Table M.

[0174] Table 65: This table shows that A is methylsulfamoyl and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ib), 65.1 to 74.1316, as defined in Table M.

[0175] Table 66: This table shows that A is ethylsulfamoyl and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ib), 66.1 to 66.1316, as defined in Table M.

[0176] Table 67: This table shows where A is dimethylsulfamoyl and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ib), 67.1 to 67.1316, as defined in Table M.

[0177] Table 68: This table shows that A is ethyl(methyl)sulfamoyl and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ib), 68.1 to 68.1316, as defined in Table M.

[0178] Table 69: This table shows the compounds where A is 1-methylpyrazol-3-yl and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ib), 69.1 to 69.1316, as defined in Table M.

[0179] Table 70: This table shows the compounds where A is methylsulfonyl and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ib), 70.1 to 70.1316, as defined in Table M.

[0180] Table 71: This table shows compounds where A is ethylsulfonyl and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ib), 71.1 to 71.1316, as defined in Table M.

[0181] Table 72: This table shows the compounds where A is propylsulfonyl and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ib), 72.1 to 72.1316, as defined in Table M.

[0182] Table 73: This table shows the compounds where A is isopropylsulfonyl and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ib), 73.1 to 73.1316, as defined in Table M.

[0183] Table 74: This table shows compounds where A is cyclopropylsulfonyl and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ib), 74.1 to 74.1316, as defined in Table M.

[0184] Table 75: This table shows that A is 1,2-dimethylimidazol-4-yl and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ib), 75.1 to 75.1316, as defined in Table M.

[0185] Table 76: This table shows that A is 1-methylimidazol-4-yl and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ib), 76.1 to 76.1316, as defined in Table M.

[0186] Table 77: This table shows compounds where A is 1-cyanocyclopropyl and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ib), 77.1 to 77.1316, as defined in Table M.

[0187] Table 78: This table shows that A is 1-cyano-1-methyl-ethyl and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ib), 78.1 to 78.1316, as defined in Table M.

[0188] Table 79: This table shows the compounds where A is (1-cyanocyclopropyl)methyl and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ib), 79.1 to 79.1316, as defined in Table M.

[0189] Table 80: This table shows where A is methylsulfanylmethyl and R 1 , R 3 and R 5discloses 1316 compounds of formula (Ib), 80.1 to 80.1316, as defined in Table M.

[0190] Table 81: This table shows where A is methylsulfonylmethyl and R 1 , R 3 and R 5 discloses 1316 compounds of formula (Ib), 81.1 to 81.1316, as defined in Table M.

[0191] Also available are certain amine intermediate compounds of formula III-a, Va, VI-a, VI-b, VII-a, IX-a, XI-a, XI-b, XII-a, XII-b, XIII-a, XIV-a, some of which are novel.

[0192] Therefore, in this specification: Compound of Formula III-a [ka] (In the formula, R 1 , R 3 and R 5 is defined for each row of table M); Compound of Formula Va [ka] (In the formula, R 1 , R 3 and R 5 is defined for each row of table M); Compound of Formula VI-a [ka] (In the formula, R 1 , R 3 and R 5 is defined for each row of table M, and R x is selected from methyl, ethyl, propyl, isopropyl, butyl, isobutyl and tert-butyl; Compound of Formula VII-a [ka] (In the formula, R 1 and R 3 is defined for each row of table M, and R x is selected from methyl, ethyl, propyl, isopropyl, butyl, isobutyl and tert-butyl; Compound of formula IX-a [ka] (In the formula, R 1 and R 3 is defined for each row of table M, and R x is selected from methyl, ethyl, propyl, isopropyl, butyl, isobutyl and tert-butyl, and LG 2 is chloro); Compound of Formula XI-a [ka] (In the formula, R 1 , R 3 , X and Y are defined in any one of Tables 1 to 48); Compound of Formula XI-b [ka] (In the formula, R 1 , R 3 and A is defined in any one of Tables 49 to 81); Compound of Formula XII-a [ka] (In the formula, R 1 , R 3 , X and Y are defined in any one of Tables 1 to 48, and LG 2 is chloro, bromo or fluoro); Compound of Formula XII-b [ka] (In the formula, R 1 , R3 and A are defined in any one of Tables 49 to 81, and LG 2 is chloro, bromo or fluoro); Compound of formula XIII-a [ka] (In the formula, R 1 and R 3 is defined for each row of table M); and Compound of formula XIV-a [ka] (In the formula, R 1 and R 3 is defined for each row of table M) is available.

[0193] The compounds of formula (I) according to the present invention are preventively and / or therapeutically useful active ingredients in the field of pest control, even at low application rates, which have a very favorable biocidal spectrum and are well tolerated by warm-blooded animal species, fish, and plants.The active ingredients according to the present invention act not only against normally susceptible animal pests, such as insects or representatives of the order Acarina, but also against all or individual developmental stages of resistant animal pests.The insecticidal or acaricidal activity of the active ingredients according to the present invention can be manifested directly, i.e., immediately or only after some time has passed, as destruction of pests, for example, during molting, or indirectly, for example, as reduced egg production and / or hatching rate.

[0194] Examples of the above animal pests are: From the order Acarina, for example: Acalitus spp., Aculus spp., Acaricalus spp., Aceria spp., Acarus siro, Amblyomma spp., Argas spp., Boophilus spp., Brevipalpus spp., Bryobia spp., Calipitrimerus spp., Chorioptes spp., Dermanyssus gallinae, Dermatophagoides spp., Eotetranychus spp. spp., Eriophyes spp., Hemitarsonemus spp., Hyalomma spp., Ixodes spp., Olygonychus spp., Ornithodoros spp., Polyphagotarsone latus, Panonychus spp., Phyllocoptruta oleivora, Phytonemus spp., Polyphagotarsonemus spp., Psoroptes spp., Rhipicephalus spp.), Rhizoglyphus spp., Sarcoptes spp., Steneotarsonemus spp., Tarsonemus spp. and Tetranychus spp.; From the order Anoplura, for example: Haematopinus spp., Linognathus spp., Pediculus spp., Pemphigus spp. and Phylloxera spp.; From the order Coleoptera, for example: Agriotes spp., Amphimallon majale, Anomala orientalis, Anthonomus spp., Aphodius spp., Astylus atromaculatus, Ataenius spp., Atomaria linearis, Chaetocnema tibialis, Cerotoma spp., Conoderus spp., Cosmopolites spp., Cotinis nitida, Curculio spp., Cyclocephala spp.), Dermestes spp., Diabrotica spp., Diloboderus abderus, Epilachna spp., Eremnus spp., Heteronychus arator, Hypothenemus hampei, Lagria vilosa, Leptinotarsa ​​decemLineata, Lissorhoptrus spp., Liogenys spp., Maecolaspis spp., Maladera castanea, Megascelis spp. spp., Melighetes aeneus, Melolontha spp., Myochrous armatus, Orycaephilus spp., Otiorhynchus spp., Phyllophaga spp., Phlyctinus spp., Popillia spp.), Psylliodes spp., Rhyssomatus aubtilis, Rhizopertha spp., Scarabaeidae, Sitophilus spp., Sitotroga spp., Somaticus spp., Sphenophorus spp., Sternechus subsignatus, Tenebrio spp., Tribolium spp. and Trogoderma spp.;. From the order Diptera, for example: Aedes spp., Anopheles spp., Antherigona soccata, Bactrocea oleae, Bibio hortulanus, Bradysia spp., Calliphora erythrocephala, Ceratitis spp., Chrysomyia spp., Culex spp., Cuterebra spp., Dacus spp., Delia spp., Drosophila melanogaster, Fannia spp. spp.), Gastrophilus spp., Geomyza tripunctata, Glossina spp., Hypoderma spp., Hyppobosca spp., Liriomyza spp., Lucilia spp., Melanagromyza spp., Musca spp., Oestrus spp., Orseolia spp., Oscinella frit, Pegomyia hyoscyami, Phorbia spp. spp.), Rhagoletis spp., Rivelia quadrifasciata, Scatella spp., Sciara spp., Stomoxys spp., Tabanus spp., Tannia spp. and Tipula spp.; From the order Hemiptera, for example: Acanthocoris scabrator, Acrosternum spp., Adelphocoris lineolatus, Aleurodes spp., Amblypelta nitida, Bathycoelia thalassina, Blissus spp., Cimex spp., Clavigrella tomentosicollis, Creontiades spp., Distantiella theobroma, Dichelops furcatus, Dysdercus spp., Edessa spp., Euchistus spp., Eurydema pulchrum, Eurygaster spp., Halyomorpha halys, Horcias nobilellus, Leptocorisa spp., Lygus spp., Margarodes spp., Murgantia histrionic, Neomegalotomus spp., Nesidiocoris tenuis, Nezara spp., Nysius simulans, Oebalus insularis insularis, Piesma spp., Piezodorus spp., Rhodnius spp., Sahlbergella singularis, Scaptocoris castanea, Scotinophara spp.), Thyanta spp., Triatoma spp., Vatiga illudens;. Acyrthosium pisum, Adalges spp., Agalliana ensigera, Agonoscena targionii, Aleurodicus spp., Aleurocanthus spp., Aleurolobus barodensis, Aleurothrixus floccosus, Aleyrodes brassicae, Amarasca biguttula, Amritodus atkinsoni, Aonidiella spp. spp.), Aphididae, Aphis spp., Aspidiotus spp., Aulacorthum solani, Bactericera cockerelli, Bemisia spp., Brachycaudus spp., Brevicoryne brassicae, Cacopsylla spp., Cavariella aegopodii Scop., Ceroplaster spp.), Chrysomphalus aonidium, Chrysomphalus dictyospermi, Cicadella spp., Cofana spectra, Cryptomyzus spp., Cicadulina spp., Coccus hesperidum, Dalbulus maidis, Dialeurodes spp., Diaphorina citri, Diuraphis noxia, Dysaphis spp., Empoasca spp., Eriosoma larigerum, Erythroneura spp., Gascardia spp., Glycaspis brimblecombei, Hyadaphis pseudobrassicae, Hyalopterus spp., Hyperomyzus pallidus, Idioscopus clypealis, Jacobiasca lybica, Laodelphax spp., Lecanium corni, Lepidosaphes spp., Lopaphis erysimi, Lyogenys maidis, Macrosiphum spp., Mahanarva spp., Metcalfa pruinosa, Metopolophium dirhodum, Myndus crudus, Myzus spp.), Neotoxoptera spp., Nephotettix spp., Nilaparvata spp., Nippolachnus piri Mats, Odonaspis ruthae, Oregma lanigera Zehnter, Bayberry whitefly (Parabemisia myricae), Paratrioza cockerelli, Parlatoria spp., Pemphigus spp., Corn planthopper (Peregrinus maidis), Perkinsiella spp., Hop wart aphid (Phorodon humuli, Phylloxera spp., Planococcus spp., Pseudaulacaspis spp., Pseudococcus spp., Pseudatomoscelis seriatus, Psylla spp., Pulvinaria aethiopica, Quadraspidiotus spp., Quesada gigas, Recilia dorsalis, Rhopalosiphum spp., Saissetia spp., Scaphoideus spp. spp.), Schizaphis spp., Sitobion spp.), Sogatella furcifera, Spisstilus festinus, Tarophagus Proserpina, Toxoptera spp., Trialeurodes spp., Tridiscus sporoboli, Trionymus spp., Trioza erytreae, Unaspis citri, Zygina flammigera, Zyginidia scutellaris; From the order Hymenoptera, for example: Acromyrmex ants, Arge spp., Atta spp., Cephus spp., Diprion spp., Diprionidae, Gilpinia polytoma, Hoplocampa spp., Lasius spp., Monomorium pharaonis ants, Neodiprion spp., Pogonomyrmex spp., Slenopsis invicta, Solenopsis spp. and Vespa spp.; From the order Isoptera, for example: Coptotermes spp., Corniternes cumulans, Incisitermes spp., Macrotermes spp., Mastotermes spp., Microtermes spp., Reticulitermes spp.; Solenopsis geminate From the order Lepidoptera, for example: Acleris spp., Adoxophyes spp., Aegeria spp., Agrotis spp., Alabama argillaceae, Amylois spp., Anticarsia gemmatalis, Archips spp., Argyresthia spp., Argyrotaenia spp., Autographa spp., Bucculatrix thurberiella, Busseola fusca, Cadra cautella, Carposina nipponensis, Chilo spp., Choristoneura spp., Chrysoteuchia topiaria, Clysia ambiguella, Cnaphalocrocis spp., Cnephasia spp., Cochylis spp., Coleophora spp., Colias lesbia, Cosmophila flava, Crambus spp., Crocidolomia binotalis, Cryptophlebia leucotreta, Cydalima perspectalis perspectalis, Cydia spp., Diaphania perspectalis, Diatraea spp., Diparopsis castanea, Earias spp.), Elasmopalpus lignosellus, Eldana saccharina, Ephestia spp., Epinotia spp., Estigmene acrea, Etiella zinckinella, Eucosma spp., Eupoecilia ambiguella, Euproctis spp., Euxoa spp., Feltia jaculiferia, Grapholita spp., Hedya nubiferana, Heliothis spp. spp.), Hellula undalis, Herpetogramma spp., Hyphantria cunea, Keiferia lycopersicella, Lasmopalpus lignosellus, Leucoptera scitella, Lithocollethis spp., Lobesia botrana, Loxostege bifidalis, Lymantria spp., Lyonetia spp., Malacosoma spp., Mamestra brassicae, Manduca sexta, Mythimna spp., Noctua spp., Operophtera spp., Orniodes indica, Ostrinia nubilalis, Pammene spp., Pandemis spp.), pine sawyer moth (Panolis flammea), Papaipema nebris, pink bollworm (Pectinophora gossypiela), coffee leafminer (Perileucoptera coffeella), Pseudaletia unipuncta, potato tuber moth (Phthorimaea operculella), cabbage white butterfly (Pieris rapae), Pieris spp., diamondback moth (Plutella xylostella), Prays spp., Pseudoplusia spp., Rachiplusia nu, Richia albicosta, Scirpophaga spp., Sesamia spp.), Sparganothis spp., Spodoptera spp., Sylepta derogate, Synanthedon spp., Thaumetopoea spp., Tortrix spp., Trichoplusia ni, Tuta absoluta and Yponomeuta spp.;. From the order Mallophaga, for example: Damalinea spp. and Trichodectes spp.; From the order Orthoptera, for example: Blatta spp., Blattella spp., Gryllotalpa spp., Leucophaea maderae, Locusta spp., Neocurtilla hexadactyla, Periplaneta spp., Scapteriscus spp. and Schistocerca spp.; From the order Psocoptera, for example: Liposcelis spp.; From the order Siphonaptera, for example: Ceratophyllus spp., Ctenocephalides spp. and Xenopsylla cheopis; From the order Thysanoptera, for example: Calliothrips phaseoli, Frankliniella spp., Heliothrips spp., Hercinothrips spp., Parthenothrips spp., Scirtothrips aurantii, Sericothrips variabilis, Taeniothrips spp., Thrips spp.; From the order Thysanura, for example, Lepisma saccharina.

[0195] In a further aspect, the present invention also relates to plant parasitic nematodes (endoparasitic, semi-endoparasitic and ectoparasitic nematodes), in particular the root-knot nematode Meloidogyne hapla, Meloidogyne incognita, Meloidogyne javanica, Meloidogyne arenaria and other Meloidogyne species; cyst-forming nematodes Globodera rostochiensis and other Globodera species; wheat cyst nematode Heterodera avenae, soybean cyst nematode Heterodera glycines, sugar beet cyst nematode Heterodera schachtii, clover cyst nematode Heterodera trifolii and other cyst nematodes (Heterodera species); seed gall nematodes, Anguina species; stem and peel nematodes, Aphelenchoides species; sting nematodes, Belonolaimus longicaudatus and other Belonolaimus species; pine wood nematode, Bursaphelenchus xylophilus and other Bursaphelenchus species; ring nematodes, Criconema species, Criconemella species, Criconemoides species, Mesocriconema species; stem and bulb nematodes, Ditylenchus destructor, Ditylenchus dipsaci and other Ditylenchus species; fire nematodes, Dolichodorus species;Screw nematodes, Heliocotylenchus multicinctus and other Helicotylenchus species; Sheath and sheathoid nematodes, Hemicycliophora species and Hemicriconemoides species; Hirshmanniella species; Spear nematodes, Hoploaimus species; False root-knot nematodes, Nacobbus species; Tylenchidae, Longidorus elongatus elongatus and other Longidorus species; pin nematodes, Pratylenchus species; root-lesion nematodes, Pratylenchus neglectus, Pratylenchus penetrans, Pratylenchus curvitatus, Pratylenchus goodeyi and other Pratylenchus species; root-lesion nematodes, Radopholus similis and other Radopholus species; false nematodes, Rotylenchus robustus, Rotylenchus reniformis and other Rotylenchus species; Scutellonema species; Trichodorus primitivus and other Trichodorus species, Paratrichodorus species;plant-parasitic nematodes such as the claytonid nematode, Tylenchorhynchus claytoni, Tylenchorhynchus dubius and other Tylenchorhynchus species; the burrowing nematode, Tylenchulus species; plant-parasitic nematodes such as the giant sting nematode, Xiphinema species; and plant-parasitic nematodes such as Subanguina species, Hypsoperine species, Macroposthonia species, Melinius species, Punctodera species and Quinisulcius species. The present invention may also relate to a method for preventing damage to plants and parts thereof by other plant-parasitic nematode species, such as Pseudomonas spp.;

[0196] The compounds of the present invention may also have activity against mollusks, such as, for example, species of the family Ampullariidae; Arion (A. ater, A. circumscriptus, A. hortensis, A. rufus); Bradybaenidae (Bradybaena fruticum); Cepaea (C. hortensis, C. rufus); Nemoralis); Ochlodina; Deroceras (D. agrestis, D. empiricorum, D. laeve, D. reticulatum); Discus (D. rotundatus); Euomphalia; Galba (G. trunculata); Helicelia (H. itala, H. obvia); Helicidae (Helicigona albustrum) arbustorum); Helicodiscus; Helix (H. aperta); Limax (L. cinereoniger, L. flavus, L. marginatus, L. maximus, L. tenellus); Monoa These include the genera Lymnaea; Milax (M. gagates, M. marginatus, M. sowerbyi); Opeas; Pomacea (P. canaticulata); Vallonia and Zanitoides.

[0197] The active ingredients according to the invention can be used to control, i.e. suppress or destroy, pests of the above-mentioned types occurring in particular on plants, in particular on useful plants and ornamental plants in agriculture, horticulture and forestry, or on organs such as the fruits, flowers, leaves, stems, tubers or roots of such plants, in some cases even plant organs formed at a later time remaining protected from these pests.

[0198] Suitable target crops are, in particular, cereals such as wheat, barley, rye, oats, rice, maize or sorghum; beets such as sugar beet or fodder beet; fruits, such as pome fruits, stone fruits or soft fruits, for example apples, pears, plums, peaches, almonds, cherries or berries, for example strawberries, raspberries or blackberries; legumes, such as beans, lentils, peas or soybeans; rapeseed, mustard, poppy, olive, sunflower, palm, castor, cocoa or groundnut. citrus fruits such as oranges, lemons, grapefruits or tangerines; vegetables such as spinach, lettuce, asparagus, cabbage, carrots, onions, tomatoes, potatoes or peppers; plants of the Lauraceae family such as avocado, cinnamon or camphor; and also tobacco, tree nuts, coffee, eggplant, sugarcane, tea, pepper, grapes, hops, plantains and latex plants.

[0199] In certain embodiments, the compounds of formula (I) control mites, rust mites, and spider mites on crops, trees, and plants selected from vegetables (especially tomatoes and cucurbits), citrus fruits, pome fruits, stone fruits, nuts, cotton, tropical crops, avocados, ornamentals, beans, soybeans, strawberries, and grapes.

[0200] The compositions and / or methods of the present invention may be used on any ornamental and / or vegetable crop, including flowers, shrubs, broadleaf trees and evergreen trees.

[0201] For example, the present invention relates to the use of the following ornamental species: Ageratum spp., Alonsoa spp., Anemone spp., Anisodontea capsenisis, Anthemis spp., Antirrhinum spp., Aster spp., Begonia spp. (e.g., B. elatior, B. semperflorens, B. tubereux), Bougainvillea spp., Brachycome spp. spp.), Brassica spp. (ornamental), Calceolaria spp., Capsicum annuum, Catharanthus roseus, Canna spp., Centaurea spp., Chrysanthemum spp., Cineraria spp. (C. maritime), Coreopsis spp., Crassula coccinea, Cuphea ignea, Dahlia spp., Delphinium spp., Bleeding hearts spectabilis, Dorotheantus spp., Lisianthus (Eustoma grandiflorum), Forsythia spp., Fuchsia spp., Geranium gnaphalium, Gerbera spp., Globetrotter (Gomphrena globosa), Heliotropium spp., Helianthus spp., Hibiscus spp.), Hortensia spp., Hydrangea spp., Hypoestes phyllostachya, Impatiens spp. (I. Walleriana), Iresines spp., Kalanchoe spp., Lantana camara, Lavatera trimestris, Leonotis leonurus, Lilium spp., Mesembryanthemum spp., Mimulus spp., Monarda spp. spp.), Nemesia spp., Tagetes spp., Dianthus spp. (carnations), Canna spp., Oxalis spp., Bellis spp., Pelargonium spp. (ivy geranium (P. peltatum), P. Zonale), Viola spp. (pansies), Petunia spp., Phlox spp., Plecthranthus spp., Poinsettia spp. spp.), Parthenocissus spp. (American Creeper (P. quinquefolia), Ivy (P. tricuspidata)), Primula spp., Ranunculus spp., Rhododendron spp., Rosa spp. (roses), Rudbeckia spp., Saintpaulia spp., Salvia spp.), Scaevola aemola, Schizanthus wisetonensis, Sedum spp., Solanum spp., Surfinia spp., Tagetes spp., Nicotinia spp., Verbena spp., Zinnia spp., and other bedding plants.

[0202] For example, the present invention relates to the use of the following vegetable species: Allium spp. (garlic (A. sativum), onion (A. cepa), shallot (A. oschaninii), leek (A. porrum), scallion (A. ascalonicum), green onion (A. fistulosum)), chervil (Anthriscus cerefolium), celery (Apium graveolus), asparagus (Asparagus officinalis), beet (Beta vulgarus), Brassica spp. (B. oleracea, Chinese cabbage (B. pekinensis), turnip (B. rapa)), chili pepper (Capsicum annuum), chickpea (Cicer arietinum), endive (Cichorium endivia), Cichorum spp. spp.) (chicory (C. intybus), endive (C. endivia)), watermelon (Citrillus lanatus), Cucumis spp. (saffron (C. sativus), melon (C. melo)), Cucurbita spp. (Cucurbita pepo, Cucurbita maxima), Cyanara spp. (artichoke (C. scolymus), cardoon (C. cardunculus)), carrot (Daucus carota), fennel (Foeniculum vulgare), Hypericum spp., lettuce (Lactuca sativa), tomato spp. spp.) (tomato (L. esculentum), tomato (L. lycopersicum)), mint species (Mentha spp.), basil (Ocimum basilicum), parsley (Petroselinum crispum), Phaseolus species (Phaseolus spp.) (P. vulgaris, runner bean (P.The present invention may be used in any of the following plants: pea (Pisum sativum), radish (Raphanus sativus), rhubarb (Rheum rhaponticum), rosemary (Rosemarinus spp.), salvia (Salvia spp.), yellow rosemary (Scorzonera hispanica), eggplant (Solanum melongena), spinach (Spinacea oleracea), Valerianella spp. (V. locusta, V. eriocarpa), and broad bean (Vicia faba).

[0203] Preferred ornamental species include Saintpaulia, Begonia, Dahlia, Gerbera, Hydrangea, Vervain, Rosa, Kalanchoe, Poinsettia, Aster, Centaurea, Coreopsis, Delphinium, Monarda, Phlox, Rudbeckia, Sedum, Petunia, Viola, Impatiens, Geranium, Chrysanthemum, Ranunculus, Fuchsia, Salvia, Hydrangea, Rosemary, Sage, St. John's Wort, Mint, Bell Pepper, Tomato, and Cucumber.

[0204] The active ingredients according to the invention are particularly suitable for controlling Aphis craccivora, Diabrotica balteata, Heliothis virescens, Myzus persicae, Plutella xylostella and Spodoptera littoralis in cotton, vegetables, corn, rice and soybean crops. The active ingredients according to the invention are particularly suitable for controlling Mamestra (preferably on vegetables), codling moth (Cydia pomonella) (preferably on apple), Empoasca (preferably on vegetables and vineyards), Leptinotarsa ​​(preferably on potato) and Chilo supressalis (preferably on rice).

[0205] The compounds of formula (I) are effective against mites, spider mites and rust mites, for example Acarapis spp; Acarapis woodi; Acarus siro; Acarus spp; Aceria sheldoni; Aculops pelekassi; Aculops spp; Aculus schlechtendali; Aculus spp; Amblyseius fallacis; Brevipalpus spp; Brevipalpus phoenicis; Bryobia praetiosa; Bryobia rubrioculus; Caloglyphus spp); Cheyletiella blakei; Cheyletiella spp; Cheyletiella yasguri; Chorioptes bovis; Chorioptes spp; Cytodites spp; Demodex bovis; Demodex caballi; Demodex canis; Demodex caprae; Demodex equi; Demodex ovis; Demodex spp; Demodex suis; Dermonychus gallinae; Dermonychus spp; Eotetranychus spp); Willamette spider mite (Eotetranychus willamettei); Pear rust mite (Epitrimerus pyri); Eriophyes ribis; Eriophyes spp; Grape leafminer mite (Eriophyes vitis);Eutetranychus spp; Halotydeus destructor; Hemitarsonemus spp; Knemidocoptes spp; Laminosioptes spp; Listrophorus spp; Myobia spp; Neoschongastia xerothermobia; Neotrombicula autumnalis; Neotrombicula desaleri; Notoedres cati; Notoedres spp; Oligonychus coffeae; Oligonychus ilicis; Oligonychus spp; Ornithocheyletia spp; Ornithonyssus bursa; Ornithonyssus spp; Ornithonyssus sylviarum; Otodectes cynotis; Otodectes spp; Panonychus citri; Panonychus spp; Panonychus ulmi; Phyllocoptruta oleivora; Phyllocoptruta spp.; Phytoseiulus spp.; Pneumonyssoides caninum; Polyphagotarsonemus latus); Polyphagotarsonemus spp; Psorergates ovis; Psorergates spp; Psoroptes cuniculi;Psoroptes equi, Psoroptes ovis, Psoroptes spp., Pterolichus spp., Raillietia spp., Rhizoglyphus spp., Sarcoptes bovis, Sarcoptes canis, Sarcoptes caprae, Sarcoptes equi, Sarcoptes ovis, Sarcoptes rupicaprae, Sarcoptes spp., Sarcoptes spp. suis; Steneotarsonemus spinki; Steneotarsonemus spp; Sternostoma spp; Tarsonemus spp; Tetranychus cinnabarinus; Tetranychus kanzawai; Tetranychus spp; Tetranychus urticae; Trombicula akamushi; Trombicula spp; Typhlodromus occidentalis; Tyrophagus spp; Varroa jacobsoni; Varroa spp spp); Vasates lycopersici; and Zetzellia mali.

[0206] In one embodiment, the compound of formula (I) is effective against Aceria sheldoni; Aculus lycopersici; Aculus pelekassi; Aculus schlechtendali; Brevipalpus phoenicis; Brevipalpus spp.; Bryobia rubrioculus; Eotetranychus carpini; Eotetranychus spp.; Epitrimerus pyri; Eriophyes piri; Eriophyes spp.; Eriophyes vitis; Eutetranychus africanus africanus; Eutetranychus orientalis; Oligonychus pratensis; Panonychus citri; Panonychus ulmi; Phyllocoptes vitis; Phyllocoptruta oleivora; Polyphagotarsonemus latus; Tetranychus cinnabarinus; Tetranychus kanzawai; Tetranychus spp.; and Tetranychus urticae.

[0207] In a further embodiment, the compound of formula (I) is effective against Aceria sheldoni; Aculus pelekassi; Brevipalpus phoenicis; Brevipalpus spp.; Eriophyes piri; Eriophyes vitis; Eutetranychus africanus; Eutetranychus orientalis; Oligonychus pratensis; Panonychus ulmi; Phyllocoptes vitis; Phyllocoptruta oleivora; Polyphagotarsonemus latus; Tetranychus cinnabarinus); Tetranychus kanzawai; Tetranychus spp.; and Tetranychus urticae.

[0208] The term "crop plant" should also be understood to include crop plants that have been transformed by the use of recombinant DNA techniques so as to be capable of synthesizing one or more selectively acting toxins, such as those known to be derived from toxin-producing bacteria, particularly bacteria of the genus Bacillus.

[0209] Toxins that can be expressed by such transgenic plants include, for example, insecticidal proteins from Bacillus cereus or Bacillus popilliae; or δ-endotoxins, such as Cry1Ab, Cry1Ac, Cry1F, Cry1Fa2, Cry2Ab, Cry3A, Cry3Bb1 or Cry9C, insecticidal proteins from Bacillus thuringiensis or plant insecticidal proteins (Vip), such as Vip1, Vip2, Vip3 or Vip3A; or bacterial-colonizing nematodes, such as Photorhabdus spp. or Xenorhabdus spp., such as Photorhabdus luminescens, Xenorhabdus nematophilus, etc. insecticidal proteins of Azotoxins; toxins produced by animals, such as scorpion toxins, arachnid toxins, wasp toxins and neurotoxins specific to other insects; toxins produced by fungi, such as Streptomycetes toxins, plant lectins, such as pea lectin, barley lectin or snowdrop lectin; agglutinins; proteinase inhibitors, such as trypsin inhibitors, serine protease inhibitors, patatin, cystatin and papain inhibitors; ricin, corn-RIP, abrin, rufin, saporin ribosome-inactivating proteins (RIPs) such as erythrin or bryodin; steroid metabolic enzymes such as 3-hydroxysteroid oxidase, ecdysteroid-UDP-glycosyl-transferase, cholesterol oxidase, ecdysone inhibitors, HMG-COA-reductase, ion channel blockers such as blockers of sodium channels or calcium channels, juvenile hormone esterase, diuretic hormone receptor, stilbene synthase, bibenzyl synthase, chitinase and glucanase.

[0210] In the context of the present invention, delta-endotoxins are understood to mean, for example, Cry1Ab, Cry1Ac, Cry1F, Cry1Fa2, Cry2Ab, Cry3A, Cry3Bb1, or Cry9C, or plant insecticidal proteins (Vip), such as Vip1, Vip2, Vip3, or Vip3A, and also specifically hybrid toxins, truncated toxins, and modified toxins. Hybrid toxins are produced recombinantly by combining different domains of these proteins (see, for example, WO 02 / 15701). Truncated toxins, such as truncated Cry1Ab, are known. In the case of modified toxins, one or more amino acids of the native toxin are replaced. In such amino acid substitutions, preferably a non-naturally occurring protease recognition sequence is inserted into the toxin, for example, in the case of Cry3A055, a cathepsin-G recognition sequence is inserted into the Cry3A toxin (see WO 03 / 018810).

[0211] Examples of such toxins or transgenic plants capable of synthesizing such toxins are disclosed, for example, in EP 0 374 753, WO 93 / 07278, WO 95 / 34656, EP 0 427 529, EP 451 878 and WO 03 / 052073.

[0212] Methods for the preparation of such transgenic plants are generally known to those skilled in the art and are described, for example, in the publications mentioned above. Deoxyribonucleic acids of the CryI type and their preparation are known, for example, from WO 95 / 34656, EP 0 367 474, EP 0 401 979 and WO 90 / 13651.

[0213] The toxins contained in the transgenic plants confer resistance to pests found in a range of insect taxa, but are particularly common in beetles (Coleoptera), two-winged insects (Diptera), and moths (Lepidoptera).

[0214] Transgenic plants containing one or more genes encoding insecticide resistance and expressing one or more toxins are known, and some of them are commercially available. Examples of such plants include YieldGard® (a corn variety expressing the Cry1Ab toxin); YieldGard Rootworm® (a corn variety expressing the Cry3Bb1 toxin); YieldGard Plus® (a corn variety expressing the Cry1Ab and Cry3Bb1 toxins); Starlink® (a corn variety expressing the Cry9C toxin); Herculex I® (a corn variety expressing the Cry1Fa2 toxin and the enzyme phosphinothricin N-acetyltransferase (PAT) for tolerance to the herbicide glufosinate ammonium); NuCOTN 33B® (a cotton variety expressing the Cry1Ac toxin); Bollgard I® (a cotton variety expressing the Cry1Ac toxin); Bollgard II® (a cotton variety expressing Cry1Ac and Cry2Ab toxins); VipCot® (a cotton variety expressing Vip3A and Cry1Ab toxins); NewLeaf® (a potato variety expressing Cry3A toxin); NatureGard®, Agrisure® GT Advantage (GA21 glyphosate tolerance trait), Agrisure® CB Advantage (Bt11 corn borer (CB) trait), and Protecta®.

[0215] Further examples of such transgenic crops are: 1. Bt11 maize, registration number C / FR / 96 / 05 / 10, manufactured by Syngenta Seeds SAS (Chemin de l'Hobit 27, F-31 790 St. Sauveur, France). This genetically modified maize is resistant to attack by the European corn borer (Ostrinia nubilalis and Sesamia nonagrioides) through the transgenic expression of a truncated Cry1Ab toxin. Bt11 maize also genetically expresses the enzyme PAT to confer tolerance to the herbicide glufosinate ammonium.

[0216] 2. Bt176 maize, registration number C / FR / 96 / 05 / 10, manufactured by Syngenta Seeds SAS (Chemin de l'Hobit 27, F-31 790 St. Sauveur, France). This genetically modified maize is resistant to attack by the European corn borer (Ostrinia nubilalis and Sesamia nonagrioides) through transgenic expression of the Cry1Ab toxin. Bt176 maize also genetically expresses the enzyme PAT to confer tolerance to the herbicide glufosinate ammonium.

[0217] 3. MIR604 maize, registration number C / FR / 96 / 05 / 10, manufactured by Syngenta Seeds SAS (Chemin de l'Hobit 27, F-31 790 St. Sauveur, France). This maize has been made insect-resistant by transgenic expression of a modified Cry3A toxin. The toxin is Cry3A055, modified by the insertion of a cathepsin-G-protease recognition sequence. The preparation of such transgenic maize plants is described in WO 03 / 018810.

[0218] 4. MON 863 maize, registration number C / DE / 02 / 9, manufactured by Monsanto Europe SA (270-272 Avenue de Tervuren, B-1150 Brussels, Belgium). MON 863 expresses the Cry3Bb1 toxin and confers resistance to certain Coleoptera insects.

[0219] 5. IPC 531 cotton, registration number C / ES / 96 / 02, manufactured by Monsanto Europe SA (270-272 Avenue de Tervuren, B-1150 Brussels, Belgium).

[0220] 6. 1507 Maize, registration number C / NL / 00 / 10, manufactured by Pioneer Overseas Corporation, Avenue Tedesco, 7 B-1160 Brussels, Belgium. Genetically modified maize for expression of the protein Cry1F for resistance to certain Lepidoptera insects and the protein PAT for resistance to the herbicide glufosinate ammonium.

[0221] 7. NK603 x MON 810 maize, registration number C / GB / 02 / M3 / 03, manufactured by Monsanto Europe SA (270-272 Avenue de Tervuren, B-1150 Brussels, Belgium). This maize consists of a conventionally bred hybrid maize variety by crossing the genetically modified varieties NK603 and MON 810. NK603 x MON 810 maize also genetically expresses the protein CP4 EPSPS, obtained from Agrobacterium sp. strain CP4, which confers resistance to the herbicide Roundup® (containing glyphosate), and the Cry1Ab toxin, obtained from Bacillus thuringiensis subsp. kurstaki, which confers resistance to certain Lepidoptera, including the European corn borer.

[0222] Transgenic crops of insect-resistant plants are also described in the BATS (Zentrum für Biosicherheit und Nachhaltigkeit, Zentrum BATS, Clarastrasse 13, 4058 Basel, Switzerland) Report 2003, (http: / / bats.ch).

[0223] The term "crop plant" should also be understood to include crop plants that have been transformed by the use of recombinant DNA technology so as to be able to synthesize antipathogenic substances with selective action, such as, for example, so-called "pathogenicity-related proteins" (PRPs, see, for example, EP-A-0 392 225). Examples of such antipathogenic substances and transgenic plants capable of synthesizing such antipathogenic substances are known, for example, from EP-A-0 392 225, WO 95 / 33818 and EP-A-0 353 191. Methods for producing such transgenic plants are generally known to those skilled in the art and are described, for example, in the above-mentioned publications.

[0224] Crops can also be improved to increase resistance to fungal (e.g., Fusarium, anthracnose, or Phytophthora), bacterial (e.g., Pseudomonas), or viral (e.g., potato leaf curl virus, tomato spotted wilt virus, cucumber mosaic virus) pathogens.

[0225] Crops also include those that have a high resistance to nematodes, such as the soybean cyst nematode.

[0226] Crops that are tolerant to abiotic stress include those that have increased tolerance to drought, high salinity, high temperature, low temperature, frost, or light due to, for example, expression of NF-YB or other proteins known in the art.

[0227] Antipathogenic substances that can be expressed by such transgenic plants include, for example, ion channel blockers, such as blockers of sodium or calcium channels, e.g., viral KP1, KP4 or KP6 toxins; stilbene synthases; bibenzyl synthases; chitinases; glucanases; so-called "pathogenesis-related proteins" (PRPs; see, for example, EP 0 392 225); antipathogenic substances produced by microorganisms, such as peptide or heterocyclic antibiotics (see, for example, WO 95 / 33818) or proteins or polypeptide factors involved in plant pathogen defense (the so-called "plant disease resistance genes" described in WO 03 / 000906).

[0228] Further fields of use of the compositions according to the invention are the protection of stored goods and storage rooms and of raw materials (such as wood and textiles), floor coverings and buildings, and in the hygiene sector, in particular the protection of humans, domestic animals and productive livestock from pests of the above-mentioned types.

[0229] The present invention provides compounds of the first aspect for use in therapy. The present invention provides compounds of the first aspect for use in controlling parasites in or on animals. The present invention further provides compounds of the first aspect for use in controlling ectoparasites on animals. The present invention further provides compounds of the first aspect for use in the prevention and / or treatment of diseases transmitted by ectoparasites.

[0230] The present invention provides the use of a compound of the first aspect for the manufacture of a medicament for controlling parasites in or on an animal. The present invention further provides the use of a compound of the first aspect for the manufacture of a medicament for controlling ectoparasites on an animal. The present invention further provides the use of a compound of the first aspect for the manufacture of a medicament for preventing and / or treating diseases transmitted by ectoparasites.

[0231] The present invention provides the use of a compound of the first aspect in the control of parasites in or on an animal. The present invention further provides the use of a compound of the first aspect in the control of ectoparasites on an animal.

[0232] When used in reference to parasites in or on animals, the term "control" refers to the reduction of pest or parasite numbers, the eradication of pests or parasites, and / or the prevention of further pest or parasite infestation.

[0233] The term "treating" when used in reference to parasites in or on an animal refers to suppressing, slowing, arresting or reversing the progression or severity of an existing condition or disease.

[0234] When used in reference to parasites in or on an animal, the term "prevent" refers to the avoidance of symptoms or disease developing in the animal.

[0235] When used in reference to parasites in or on animals, the term "animal" can refer to mammals and non-mammals such as birds or fish. In the case of mammals, this can be a human or non-human mammal. Non-human mammals include, but are not limited to, livestock animals and companion animals. Livestock animals include, but are not limited to, cattle, camelids, pigs, sheep, goats, and horses. Companion animals include, but are not limited to, dogs, cats, and rabbits.

[0236] A "parasite" is a pest that lives in or on a host animal and benefits from nutrients provided at the expense of the host animal. An "endoparasite" is a parasite that lives inside the body of a host animal. An "ectoparasite" is a parasite that lives on a host animal. Ectoparasites include, but are not limited to, mites, insects, and crustaceans (e.g., sea lice). The subclass Acari (or Acarina) includes ticks and mites. Ticks include, but are not limited to, members of the following genera: Rhipicaphalus, such as Rhipicaphalus (Boophilus) microplus and Rhipicephalus sanguineus; Amblyomma; Dermacentor; Haemaphysalis; Hyalomma; Ixodes; Rhipicentor; Margaropus; Argas; Otobius; and Ornithodoros. Mites include, but are not limited to, members of the following genera: Chorioptes, such as Chorioptes bovis; Psoroptes, such as Psoroptes ovis; Cheyletiella; Dermanyssus, such as Dermanyssus gallinae; Ortnithonyssus; Demodex, such as Demodex canis; Sarcoptes, such as Sarcoptes scabiei; and Psorergates.Insects include, but are not limited to, members of the following orders: Siphonaptera, Diptera, Chelonia, Lepidoptera, Coleoptera, and Homoptera. Members of the Siphonaptera order include, but are not limited to, the cat flea (Ctenocephalides felis) and the dog flea (Ctenocephatides canis). Members of the order Diptera include, but are not limited to, Musca species; bot flies, such as Gasterophilus intestinalis and Oestrus ovis; stable flies; horse flies, such as Haematopota species and Tabunus species; haematobia, such as Haematobia irritans; Stomoxys; Lucilia; midges; and mosquitoes. Members of the order Chestnuti include, but are not limited to, sucking and biting lice, such as Bovicola ovis and Bovicola bovis.

[0237] When used in connection with parasites in or on animals, the term "effective amount" refers to the amount or dosage of a compound of the present invention or a salt thereof that, upon administration to the animal in one or more doses, produces the desired effect in or on the animal. An effective amount can be readily determined by the attending diagnostician, as one skilled in the art, by using known techniques and observing results obtained under analogous circumstances. In determining an effective amount, the attending diagnostician will take into account numerous factors, including, but not limited to, the species of mammal; its size, age, and general health; the parasite and level of infestation to be controlled; the particular disease or disorder involved; the extent or complications or severity of the disease or disorder; the individual's response; the particular compound administered; the mode of administration; the bioavailability characteristics of the administered preparation; the selected dosage regimen; the use of concomitant medications; and other relevant circumstances.

[0238] The compounds of the present invention can be administered to animals by any route that has the desired effect, including, but not limited to, topical, oral, parenteral, and subcutaneous administration. Topical administration is preferred. Formulations suitable for topical administration include, for example, solutions, emulsions, and suspensions, and can be in the form of pour-ons, spots, spray-ons, spray-laces, or dips. Alternatively, the compounds of the present invention can be administered by ear tag or collar.

[0239] Salt forms of the compounds of the present invention include both pharmaceutically and veterinarily acceptable salts, which may differ from agrochemically acceptable salts. Pharmaceutically and veterinarily acceptable salts and general methodologies for preparing them are well known in the art. See, for example, Gould, PL, "Salt selection for basic drugs," International Journal of Pharmaceutics, 33:201-217 (1986); Bastin, RJ, et al., "Salt Selection and Optimization Procedures for Pharmaceutical New Chemical Entities," Organic Process Research and Development, 4:427-435 (2000); and Berge, SM, et al., "Pharmaceutical Salts," Journal of Pharmaceutical Sciences, 66:1-19 (1977). Those skilled in the art of synthesis will understand that the compounds of the present invention can be easily converted to salts such as hydrochlorides and isolated as such salts using techniques and conditions well known to those skilled in the art. Additionally, those skilled in the art of synthesis will recognize that compounds of the present invention can be readily converted from a corresponding salt to the corresponding free base, and isolated as such a salt.

[0240] The present invention also provides methods for controlling pests (such as mosquitoes and other disease vectors; see also http: / / www.who.int / malaria / vector_control / irs / en / ). In one embodiment, the method for controlling pests comprises applying a composition of the present invention to the target pest, its habitat, or a surface or substrate by brushing, rolling, spraying, painting, or dipping. By way of example, IRS (indoor residual spray) application of surfaces such as walls, ceilings, or floors is contemplated by the method of the present invention. In another embodiment, it is contemplated to apply such compositions to substrates such as nonwoven or woven materials in the form of (or in a form that can be used to manufacture) netting, clothing, bedding, curtains, and tents.

[0241] In one embodiment, a method for controlling such pests comprises applying a pesticidally effective amount of a composition of the present invention to a target pest, its habitat, or a surface or substrate to provide effective, residual pest control activity to the surface or substrate. Such application may be by brushing, rolling, spraying, painting, or dipping the pesticidal composition of the present invention. For example, IRS application to surfaces such as walls, ceilings, or floors is contemplated by the method of the present invention to provide effective, residual pest control activity to the surface. In another embodiment, the application of such compositions for residual pest control on substrates such as fabric materials in the form of (or in the form that can be used to manufacture) netting, clothing, bedding, curtains, and tents is contemplated.

[0242] The substrates to be treated, including nonwovens, fabrics, or nets, can be made of natural fibers such as cotton, raffia, jute, flax, sisal, hemp, or wool, or synthetic fibers such as polyamide, polyester, polypropylene, or polyacrylonitrile. Polyesters are particularly suitable. Methods for treating textiles are known, for example, from WO 2008 / 151984, WO 2003 / 034823, U.S. Pat. No. 5,631,072, WO 2005 / 64072, WO 2006 / 128870, EP 1 724 392, WO 2005 113 886, or WO 2007 / 090739.

[0243] A further field of use for the compositions according to the invention is that of trunk injection / trunk treatment of all ornamental trees and all kinds of fruit and nut-bearing trees.

[0244] In the field of trunk injection / trunk treatment, the compounds according to the invention are particularly suitable against wood-boring insects of the above-mentioned orders Lepidoptera and Coleoptera, in particular the woodborers listed in Tables A and B below.

[0245] [Table 2]

[0246] [Table 3-1] [Table 3-2] [Table 3-3]

[0247] The present invention may be used to control any insect pest that may be present in turfgrass, including, for example, beetles, caterpillars, fire ants, ground pearls, millipedes, pill bugs, mites, mole crickets, scale insects, mealybugs, mites, boxworms, southern chinch bugs, and grubs. The present invention may also be used to control insect pests in various stages of their life cycle, including eggs, larvae, nymphs, and adults.

[0248] In particular, the present invention relates to the treatment of grubs (Cyclocephala spp. (e.g., masked chafer, C. lurida), Rhizotrogus spp. (e.g., European chafer, R. majalis), Cotinus spp. (e.g., blue swallowtail, C. nitida), Popillia spp. (e.g., Japanese beetle, P. japonica), Phyllophaga spp. (e.g., May / June beetle), Ataenius spp., and the like). spp. (e.g., Black turfgrass ataenius, A. spretulus), Maladera spp. (e.g., red-veined scarab beetle, M. castanea) and Tomarus spp.), cotton bollworms (Margarodes spp.), mole crickets (tawny, southern and brachypterous; Scapteriscus spp., Gryllotalpa africana) and leatherjackets (European crane fly, Tipula The compounds may be used to control insect pests that feed on the roots of turfgrass, including Pseudomonas spp.

[0249] The present invention may also be used to control straw-dwelling insect pests of turfgrass, including cutworms (such as Spodoptera frugiperda and the common armyworm (Pseudaletia unipuncta)), cutworms, weevils (such as Sphenophorus spp., S. venatus verstitus, and S. parvulus) and sod webworms (such as Crambus spp. and the tropical sod webworm, Herpetogramma phaeopteralis).

[0250] The present invention may also be used to control insect pests that live on the ground and feed on turfgrass leaves, including the lesser stink bug (such as the southern kinkbag, Blissus insularis), bermudagrass mite (Eriophyes cynodoniensis), rhodesgrass mealybug (Antonina graminis), two-lined spittlebug (Propsapia bicincta), leafhoppers, cutworms (Noctuidae), and greengrass aphids.

[0251] The present invention may also be used to control other pests of turfgrass, such as the red fire ant (Solenopsis invicta), which creates ant mounds in turfgrass.

[0252] In the hygiene field, the compositions according to the invention are effective against ectoparasites such as hard ticks, soft ticks, scabies mites, chiggers, flies (stable flies and licking flies), parasitic fly larvae, lice, pubic lice, biting lice and fleas.

[0253] Examples of such parasites are: Among the Anoplurida, the genera Haematopinus, Linognathus, Pediculus, Phtirus, and Solenopotes are included.

[0254] From the order Mallophagida, the genera Trimenopon, Menopon, Trinoton, Bovicola, Werneckiella, Lepikentron, Damalina, Trichodectes and Felicola.

[0255] Among the order Diptera and its suborders Nematocerina and Brachycerina, for example, the genera Aedes, Anopheles, Culex, Simulium, Eusimulium, Phlebotomus, Lutzomyia, Culicoides, Chrysops, Hybomitra, Atylotus, Tabanus, Haematopota, spp.), Philipomyia spp., Braula spp., Musca spp., Hydrotaea spp., Stomoxys spp., Haematobia spp., Morellia spp., Fannia spp., Glossina spp., Calliphora spp., Lucilia spp., Chrysomyia spp., Wohlfahrtia spp., Sarcophaga spp.), sheep flies (Oestrus spp.), cow flies (Hypoderma spp.), bot flies (Gasterophilus spp.), hood flies (Hippobosca spp.), deer flies (Lipoptena spp.) and sheep hood flies (Melophagus spp.).

[0256] Among the Siphonapterida, for example, the human flea genus (Pulex spp.), the dog flea genus (Ctenocephalides spp.), the mouse flea genus (Xenopsylla spp.), and the long flea genus (Ceratophyllus spp.).

[0257] From the order Heteropterida, for example, Cimex spp., Triatoma spp., Rhodnius spp., and Panstrongylus spp.

[0258] From the order Blattaria, for example, the Asian cockroach (Blatta orientalis), the American cockroach (Periplaneta americana), the German cockroach (Blattela germanica) and the genus Supella.

[0259] Among the subclass Acaria (Acarida) and the suborder Metastigmata and Mesostigmata, for example, the genera Argas spp., Ornithodorus spp., Otobius spp., Ixodes spp., Amblyomma spp., Boophilus spp., Dermacentor spp., Haemophysalis spp., Hyalomma spp., Rhipicephalus spp., Dermanyssus spp., Raillietia spp. spp.), Pneumonyssus spp., Sternostoma spp. and Varroa spp.

[0260] From the orders Actinedida (Prostigmata) and Acaridida (Astigmata), for example, the genera Acarapis, Cheyletiella, Ornithocheyletia, Myobia, Psorergates, Demodex, Trombicula, Listrophorus, Acarus, Tyrophagus, Caloglyphus, Hypodectes spp.), Pterolichus spp., Psoroptes spp., Chorioptes spp., Otodectes spp., Sarcoptes spp., Notoedres spp., Knemidocoptes spp., Cytodites spp. and Laminosioptes spp.

[0261] The compositions according to the invention are also suitable for protecting against insect infestation in materials such as wood, textiles, plastics, adhesives, glues, paints, paper and cardboard, leather, floor coverings and building materials.

[0262] The compositions according to the invention can be used, for example, against the following pests: European house borer (Hylotrupes bajulus), Chlorophorus pilosis, Anobium punctatum, Xestobium rufovillosum, Ptilinuspecticornis, Dendrobium pertinex, pine wood beetle (Ernobius mollis), longhorn beetle (Priobium carpini), flat-headed beetle (Lyctus brunneus), African flat-headed beetle (Lyctus africanus), American flat-headed beetle (Lyctus planicollis), oak flat-headed beetle (Lyctus beetles such as Xyleborus species, Tryptodendron species, Apate monachus, Bostrychus capucins, Heterobostrychus brunneus, Sinoxylon species and Dinoderus minutus, as well as beetles such as Sirex juvencus, Urocerus gigas, Urocerus gigas Hymenopteran insects such as Kalotermes flavicollis, Cryptotermes brevis, Heterotermes indicola, and Urocerus augur, as well as hymenopteran insects such as Kalotermes flavicollis, Cryptotermes brevis, and Heterotermes indicola.indicola, Reticulitermes flavipes, Reticulitermes santonensis, Reticulitermes lucifugus, Mastotermes darwiniensis, Zootermopsis nevadensis and Coptotermes formosanus, as well as silverfish such as Lepisma saccharina. The compounds of formula I and I'a or salts thereof are particularly suitable for controlling one or more pests selected from the families: Noctuidae, Plutellidae, Chrysomelidae, Thripidae, Pentatomidae, Tortricidae, Delphacidae, Aphididae, Noctuidae, Crambidae, Meloidogynidae and Heteroderidae. In a preferred embodiment of each aspect, compound TX (wherein the abbreviation "TX" means "one compound selected from the compounds defined in Tables 1 to 81 and Tables P1 to P6") controls one or more pests selected from the families: Noctuidae, Plutellidae, Chrysomelidae, Thripidae, Pentatomidae, Tortricidae, Delphacidae, Aphididae, Noctuidae, Crambidae, Meloidogynidae, and Heteroderidae.

[0263] The compounds of formula I and I'a or salts thereof are effective against pests of the genera Spodoptera spp., Plutella spp., Frankliniella spp., Thrips spp., Euschistus spp., Cydia spp., Nilaparvata spp., Myzus spp., Aphis spp., Diabrotica spp., Rhopalosiphum spp., Pseudoplusia spp. and Chilo spp. spp. In a preferred embodiment of each aspect, the compound TX (wherein the abbreviation "TX" means "one compound selected from the compounds defined in Tables 1 to 81 and Tables P1 to P6") is selected from the genera: Spodoptera spp., Plutella spp., Frankliniella spp., Thrips spp., Euschistus spp., Cydia spp., Nilaparvata spp., Myzus spp., Aphis spp., Diabrotica spp., Rhopalosiphum spp., Pseudoplusia spp. The compound controls one or more pests selected from Chilo spp. and Chilo spp.

[0264] The compounds of formula I and I'a or salts thereof are particularly suitable for controlling one or more of Spodoptera littoralis, diamondback moth (Plutella xylostella), western flower thrips (Frankliniella occidentalis), onion thrips (Thrips tabaci), Euschistus heros, codling moth (Cydia pomonella), brown planthopper (Nilaparvata lugens), green peach aphid (Myzus persicae), Chrysodeixis includens, bean aphid (Aphis craccivora), Diabrotica balteata, Rhopalosiphum padi and rice stem borer (Chilo suppressalis).

[0265] In a preferred embodiment of each aspect, compound TX (wherein the abbreviation "TX" means "one compound selected from the compounds defined in Tables 1 to 81 and Tables P1 to P6") is effective against Spodoptera littoralis, diamondback moth (Plutella xylostella), western flower thrips (Frankliniella occidentalis), onion thrips (Thrips tabaci), Euschistus heros, codling moth (Cydia pomonella), brown planthopper (Nilaparvata lugens), green peach aphid (Myzus persicae), Chrysodeixis includens, bean aphid (Aphis craccivora), Diabrotica balteata, Rhopalosiphum padiata, Padia and the Egyptian armyworm (Spodoptera littoralis) + TX, diamondback moth (Plutella xylostella) + TX, and other rice stem borers (Chilo Suppressalis) such as; western flower thrips (Frankliniella occidentalis) + TX, onion thrips (Thrips tabaci) + TX, Euschistus heros + TX, codling moth (Cydia pomonella) + TX, brown planthopper (Nilaparvata lugens) + TX, green peach aphid (Myzus persicae) + TX, Chrysodeixis includens + TX, bean aphid (Aphis craccivora) + TX, Diabrotica balteata + TX, Rhopalosiphum Padi) + TX and rice stem borer (Chilo suppressalis) + TX.

[0266] In one embodiment of each aspect, one compound from Tables 1-81 and Tables P1-P6 is used to control Spodoptera littoralis, Plutella xylostella, Frankliniella occidentalis, Thrips tabaci, Euschistus heros, Cydia pomonella, Nilaparvata lugens, Myzus persicae, Chrysodeixis includens, Aphis craccivora, Diabrotica balteata, Rhopalosiphum padiata, Rhopalosiphum nigricans, Rhopalosiphum padiata ... Padia) and rice stem borer (Chilo suppressalis).

[0267] In one embodiment one compound from Tables 1 to 81 and Tables P1 to P6 is suitable for controlling Mamestra (preferably in vegetables), codling moth (Cydia pomonella) (preferably in apple), Empoasca (preferably in vegetables, vineyards), Leptinotarsa ​​(preferably in potato) and Chilo supressalis (preferably in rice).

[0268] The compounds of the present invention may have any number of benefits, including, inter alia, advantageous levels of biological activity for protecting plants against insects or superior properties for use as agrochemical active ingredients (e.g., high biological activity, advantageous spectrum of activity, high safety profile (e.g., improved physicochemical properties or high biodegradability against above- and below-ground non-target organisms such as fish, birds and bees)). In particular, it has surprisingly been found that certain compounds of formula (I) may exhibit advantageous safety profiles, especially against non-target arthropods, such as pollinators such as honeybees, solitary bees and bumblebees, most particularly the European honeybee (Apis mellifera).

[0269] Although the compounds of the present invention can be used as pesticides in their native form, they are generally formulated into compositions using formulation aids such as carriers, solvents, and surfactants in various ways. The formulations can be in various physical forms, such as dustable powders, gels, wettable powders, water-dispersible granules, water-dispersible tablets, effervescent pellets, emulsifiable concentrates, microemulsifiable concentrates, oil-in-water emulsions, oil-based flowables, aqueous dispersions, oil-based dispersions, suspoemulsions, capsule suspensions, emulsifiable granules, soluble liquids, water-soluble concentrates (containing water or a water-miscible organic solvent as a carrier), impregnated polymer films, or other forms known from, for example, the Manual on Development and Use of FAO and WHO Specifications for Pesticides, United Nations, First Edition, Second Revision (2010). Such formulations can be used directly or diluted before use. Dilution can be carried out, for example, with water, liquid fertilizers, trace elements, biological materials, oils, or solvents.

[0270] The formulations can be prepared by mixing the active ingredient with formulation aids to obtain a composition in the form of, for example, finely divided solids, granules, solutions, dispersions, or emulsions. The active ingredient can also be formulated with other adjuvants, such as finely divided solids, mineral oil, vegetable or animal oil, modified vegetable or animal oil, organic solvent, water, surfactant, or combinations thereof.

[0271] The active ingredient can also be contained in extremely fine microcapsules. Microcapsules contain the active ingredient in a porous carrier, allowing the active ingredient to be released into the environment in controlled amounts (e.g., sustained release). Microcapsules typically have diameters of 0.1 to 500 microns. They contain the active ingredient in an amount of about 25 to 95% by weight of the capsule. The active ingredient can be in the form of a bulk solid, fine particles in a solid or liquid dispersion, or a suitable solution. The encapsulating membrane can comprise, for example, natural or synthetic rubber, cellulose, styrene / butadiene copolymer, polyacrylonitrile, polyacrylate, polyester, polyamide, polyurea, polyurethane, or chemically modified polymers, and starch xanthate, or other polymers known to those skilled in the art. Alternatively, extremely fine microcapsules can be formed containing the active ingredient in the form of fine particles in a base solid matrix, but the microcapsules themselves are not encapsulated.

[0272] The formulation auxiliaries suitable for preparing the compositions according to the invention are known per se. Examples of liquid carriers include water, toluene, xylene, petroleum ether, vegetable oils, acetone, methyl ethyl ketone, cyclohexanone, acid anhydrides, acetonitrile, acetophenone, amyl acetate, 2-butanone, butylene carbonate, chlorobenzene, cyclohexane, cyclohexanol, alkyl esters of acetic acid, diacetone alcohol, 1,2-dichloropropane, diethanolamine, p-diethylbenzene, diethylene glycol, diethylene glycol abietic acid, diethylene glycol butyl ether, diethylene glycol ethyl ether, diethylene glycol methyl ether, N,N-dimethylformamide, dimethyl sulfoxide, 1,4-dioxane, dipropylene glycol, dipropylene glycol methyl ether, dipropylene glycol dibenzoate, diproxitol, alkylpyrrolidone, ethyl acetate, 2-ethylhexanol, ethylene carbonate, 1,1,1-Trichloroethane, 2-heptanone, α-pinene, d-limonene, ethyl lactate, ethylene glycol, ethylene glycol butyl ether, ethylene glycol methyl ether, γ-butyrolactone, glycerol, glycerol acetate, glycerol diacetate, glycerol triacetate, hexadecane, hexylene glycol, isoamyl acetate, isobornyl acetate, isooctane, isophorone, isopropyl benzene, isopropyl myristate, lactic acid, laurylamine, mesityl oxide, methoxypropanol, methyl isoamyl ketone, methyl isobutyl ketone, methyl laurate, methyl octanoate, methyl oleate, methylene chloride, m-xylene, n-hexane, n-octylamine, octadecanoic acid, octylamine acetate Examples of suitable solvents include ethanol, oleic acid, oleylamine, o-xylene, phenol, polyethylene glycol, propionic acid, propyl lactate, propylene carbonate, propylene glycol, propylene glycol methyl ether, p-xylene, toluene, triethyl phosphate, triethylene glycol, xylene sulfonic acid, paraffin, mineral oil, trichloroethylene, perchloroethylene, ethyl acetate, amyl acetate, butyl acetate, propylene glycol methyl ether, diethylene glycol methyl ether, methanol, ethanol, isopropanol and high molecular weight alcohols such as amyl alcohol, tetrahydrofurfuryl alcohol, hexanol, octanol, ethylene glycol, propylene glycol, glycerol, and N-methyl-2-pyrrolidone.

[0273] Suitable solid carriers are, for example, talc, titanium dioxide, pyrophyllite clay, silica, attapulgite clay, kiesl lager, limestone, calcium carbonate, bentonite, calcium montmorillonite, cotton hulls, wheat flour, soybean flour, pumice, wood flour, ground walnut shells, lignin, and similar materials.

[0274] Many surface-active substances can be used advantageously in both solid and liquid formulations, especially in formulations that can be diluted with a carrier before use. The surface-active substances can be anionic, cationic, nonionic, or polymeric, and they can be used as emulsifying agents, wetting agents, or suspending agents, or for other purposes. Typical surface-active substances include, for example, salts of alkyl sulfates such as diethanolammonium lauryl sulfate; salts of alkylarylsulfonates such as calcium dodecylbenzenesulfonate; alkylphenol / alkylene oxide adducts such as nonylphenol ethoxylate; alcohol / alkylene oxide adducts such as tridecyl alcohol ethoxylate; soaps such as sodium stearate; salts of alkylnaphthalenesulfonates such as sodium dibutylnaphthalenesulfonate; dialkyl esters of sulfosuccinates such as sodium di(2-ethylhexyl)sulfosuccinate; sorbitol esters such as sorbitol oleate; quaternary amines such as lauryltrimethylammonium chloride, polyethylene glycol esters of fatty acids such as polyethylene glycol stearate; block copolymers of ethylene oxide and propylene oxide; and salts of mono- and di-alkyl phosphate esters; and further substances described, for example, in McCutcheon's Detergents and Emulsifiers Annual, MC Publishing Corp., Ridgewood, New Jersey (1981).

[0275] Additional adjuvants that may be used in the pest control formulations include crystallization inhibitors, viscosity modifiers, suspending agents, dyes, antioxidants, foaming agents, light absorbers, mixing aids, antifoaming agents, complexing agents, neutralizing or pH adjusting and buffering agents, corrosion inhibitors, fragrances, wetting agents, uptake enhancers, trace elements, plasticizers, glidants, lubricants, dispersants, thickeners, antifreeze agents, fungicides and liquid and solid fertilizers.

[0276] The compositions of the present invention may contain additives including vegetable or animal oils, mineral oils, alkyl esters of such oils, or mixtures of such oils and oil derivatives. The amount of oil additive in the compositions of the present invention is generally 0.01 to 10% based on the mixture to be applied. For example, the oil additive can be added to the spray tank at the desired concentration after the spray mixture has been prepared. Preferred oil additives include mineral oils or vegetable oils such as rapeseed oil, olive oil, or sunflower oil, emulsified vegetable oils, alkyl esters of vegetable oils such as methyl derivatives, or animal oils such as fish oil or beef tallow. Preferred oil additives are C8 to C 22 Alkyl esters of fatty acids, especially C 12 ~C 18 Methyl derivatives of fatty acids, including, for example, the methyl esters of lauric acid, palmitic acid, and oleic acid (methyl laurate, methyl palmitate, and methyl oleate, respectively). Many oil derivatives are listed in the Compendium of Herbicide Adjuvants, 10 th Edition, Southern Illinois University, 2010.

[0277] The compositions of the present invention generally comprise 0.1 to 99% by weight, especially 0.1 to 95% by weight, of the compounds of the present invention and 1 to 99.9% by weight of formulation aids, which preferably include 0 to 25% by weight of surfactants. Although commercial products may preferably be formulated as concentrates, end users will typically utilize diluted formulations.

[0278] The application rates vary within wide limits and depend on the nature of the soil, the method of application, the crop plant, the pests to be controlled, the prevailing weather conditions and other factors which depend on the method, time of application and the target crop. As a general guideline, the compounds may be applied in amounts of 1 to 2000 l / ha, especially 10 to 1000 l / ha.

[0279] A preferred formulation may have the following composition (by weight): Emulsifiable concentrate: Active ingredient: 1-95%, preferably 60-90% Surface active agent: 1 to 30%, preferably 5 to 20% Liquid carrier: 1 to 80%, preferably 1 to 35%

[0280] Powder: Active ingredient: 0.1 to 10%, preferably 0.1 to 5% Solid carrier: 99.9 to 90%, preferably 99.9 to 99%

[0281] Suspension concentrate: Active ingredient: 5-75%, preferably 10-50% Water: 94-24%, preferably 88-30% Surface active agent: 1 to 40%, preferably 2 to 30%

[0282] Wettable powder: Active ingredient: 0.5 to 90%, preferably 1 to 80% Surface active agent: 0.5 to 20%, preferably 1 to 15% Solid carrier: 5 to 95%, preferably 15 to 90%

[0283] Granules: Active ingredient: 0.1 to 30%, preferably 0.1 to 15% Solid carrier: 99.5 to 70%, preferably 97 to 85%

[0284] The following examples further illustrate, but do not limit, the present invention.

[0285] [Table 4]

[0286] This combination is thoroughly mixed with adjuvants and the mixture is thoroughly ground in a suitable mill to obtain a wettable powder, which is diluted with water to obtain a suspension of the desired concentration.

[0287] [Table 5]

[0288] This combination is thoroughly mixed with an adjuvant and the mixture is thoroughly ground in a suitable mill to obtain a dust that can be used directly as a seed treatment.

[0289] [Table 6]

[0290] Emulsions of any desired dilution that can be used for plant protection are obtained from this concentrate by dilution with water.

[0291] [Table 7]

[0292] Ready-to-use dusts are obtained by combining and mixing with a carrier and grinding the mixture in a suitable mill. Such powders can also be used for dry seed dressing.

[0293] [Table 8]

[0294] This combination is mixed with an adjuvant, ground, the mixture is wetted with water, extruded, and then dried in a stream of air.

[0295] [Table 9]

[0296] This micronized combination is applied uniformly in a mixer to kaolin wetted with polyethylene glycol, thus obtaining coated granules that do not generate dust.

[0297] [Table 10]

[0298] The finely ground composite is thoroughly mixed with adjuvants to give a suspension concentrate which can be diluted with water to give a suspension of any desired dilution, and such dilutions can be used to treat and protect living plants and plant propagation material against microbial infestation by spraying, pouring or dipping.

[0299] [Table 11]

[0300] The finely ground composite is thoroughly mixed with adjuvants to give a suspension concentrate which can be diluted with water to give a suspension of any desired dilution, and such dilutions can be used to treat and protect living plants and plant propagation material against microbial infestation by spraying, pouring or dipping.

[0301] Slow-release capsule suspension 28 parts of the composite are mixed with 2 parts aromatic solvent and 7 parts toluene diisocyanate / polymethylene-polyphenylisocyanate (8:1) mixture. This mixture is emulsified in a mixture of 1.2 parts polyvinyl alcohol, 0.05 parts defoamer, and 51.6 parts water until the desired particle size is achieved. A mixture of 2.8 parts 1,6-diaminohexane in 5.3 parts water is added to this emulsion. The mixture is stirred until the polymerization reaction is complete. The resulting capsule suspension is stabilized by adding 0.25 parts thickener and 3 parts dispersant. The capsule suspension formulation contains 28% active ingredient. The diameter of the medium-sized capsules is 8 to 15 microns. The resulting formulation is applied to seeds as an aqueous suspension in an apparatus suitable for this purpose.

[0302] Formulation types include emulsion concentrates (EC), suspension concentrates (SC), suspoemulsions (SE), capsule suspensions (CS), water dispersible granules (WG), emulsifiable granules (EG), emulsions, water-in-oil (EO), emulsions, oil-in-water (EW), microemulsions (ME), oil dispersions (OD), oil-miscible flowables (OF), oil-miscible liquids (OL), soluble concentrates (SL), ultra-low volume suspensions (SU), ultra-low volume liquids (UL), technical concentrates (TK), dispersible concentrates (DC), wettable powders (WP), soluble granules (SG) or any technically preferred formulation in combination with agriculturally acceptable adjuvants. [Example]

[0303] Preparation example: LCMS method: Method 1: Spectra were recorded on a Waters mass spectrometer (SQD single quadrupole mass spectrometer) equipped with an electrospray source (polarity: positive or negative ion, full scan, capillary: 3.00 kV, cone range: 41 V, source temperature: 150 °C, desolvation temperature: 500 °C, cone gas flow: 50 L / Hr, desolvation gas flow: 1000 L / Hr, mass range: 110–800 Da) and a Waters H-Class UPLC: quaternary pump, heated column compartment, and diode-array detector. Column: Acquity UPLC HSS T3 C18, 1.8 μm, 30 × 2.1 mm; Temperature: 40 °C; DAD wavelength range (nm): 200–400; Solvent gradient: A = water + 5% acetonitrile + 0.1% HCOOH, B = acetonitrile + 0.05% HCOOH; Gradient: 10% B at 0 min; 10–50% B at 0.2–0.2 min; 50–100% B at 0.2–0.7 min; 100% B at 0.7–1.3 min; 100–10% B at 1.3–1.4 min; 10% B at 1.4–1.6 min; Flow (mL / min): 0.6.

[0304] Method 2: Spectra were recorded on an Agilent Technologies mass spectrometer (6410 triple quadrupole mass spectrometer) equipped with an electrospray source (polarity: positive or negative ion, MS2 scan, capillary: 4.00 kV, fragmentor: 100 V, desolvation temperature: 350 °C, gas flow: 11 L / min, nebulizer gas: 45 psi, mass range: 110–1000 Da) and an Agilent 1200 Series HPLC: quaternary pump, heated column compartment, and diode-array detector. Column: KINETEX EVO C18, 2.6 μm, 50 × 4.6 mm, Temperature: 40 °C, DAD wavelength range (nm): 210–400, Solvent gradient: A = 95% (water + 0.1% HCOOH): 5% acetonitrile, B = acetonitrile + 0.1% HCOOH: Gradient: 10% B at 0 min; 100% B at 0.9–1.8 min; 100–10% B at 1.8–2.2 min; 10% B at 2.2–2.5 min, Flow rate (mL / min) 1.8.

[0305] Method 3: Spectra were recorded on a Waters mass spectrometer (Acquity QDa mass spectrometer) equipped with an electrospray source (polarity: anode and cathode switched), capillary: 0.8 kV, cone range: 25 V, extractor: V (no extractor voltage for the QDa detector), source temperature: 120 °C, desolvation temperature: 600 °C, cone gas flow: 50 L / h, desolvation gas flow: 1000 L / h, mass range: 110–850 Da) and a Waters Acquity UPLC: Quaternary solvent manager, heated column compartment, and diode-array detector. Column: Waters UPLC HSS T3, 1.8 μm, 30 × 2.1 mm, Temperature: 40 °C, PDA wavelength range (nm): 230–400, Solvent gradient: A = water + 0.1% formic acid:acetonitrile: 95:5 v / v, B = acetonitrile + 0.05% formic acid, Gradient: 0 min–1.0 min, 10% B–90% A; 1.0 min–4.50 min, 10%–100% B; 4.51 min–5.30 min, 100% B, 0% A; 5.31 min–5.50 min, 100%–10% B; 5.51 min–6.00 min, 10% B, 90% A; Flow (ml / min): 0.6.

[0306] Method 4: Spectra were recorded on an Agilent Technologies mass spectrometer (6410 Triple Quadrupole Mass Spectrometer) equipped with an electrospray source (polarity: positive or negative ion, MS2 Scan, capillary: 7.00 kV, fragmentor: 120 V, desolvation temperature: 350 °C, gas flow: 11 L / min, nebulizer gas: 40 psi, mass range: 110–1000 Da) and an Agilent 1200 Series HPLC: quaternary pump, heated column compartment, and diode-array detector. Column: KINETEX EVO C18, 2.6 μm, 50 × 4.6 mm, Temperature: 40 °C, Detector VWD wavelength: 254 nm, Solvent gradient: A = water + 5% acetonitrile + 0.1% HCOOH, B = acetonitrile + 0.1% HCOOH: Gradient: 10% B for 0 min, 90% A; 100% B for 0.9–1.8 min; 100–10% B for 1.8–2.2 min; 10% B for 2.2–2.5 min; Flow (mL / min): 1.8.

[0307] Method 5: Spectra were recorded on a Waters Corporation ACQUITY mass spectrometer (SQD or SQDII single quadrupole mass spectrometer) equipped with an electrospray source (polarity: positive or negative, capillary: 3.0 kV, cone: 30 V, extractor: 3.00 V, source temperature: 150 °C, desolvation temperature: 400 °C, cone gas flow: 60 L / hr, desolvation gas flow: 700 L / hr, mass range: 140-800 Da) and a Waters Corporation ACQUITY UPLC equipped with a solvent degasser, binary pump, heated column compartment, and diode-array detector. Column: Waters UPLC HSS T3, 1.8 μm, 30 × 2.1 mm; Temperature: 60 °C; DAD wavelength range (nm): 210–400; Solvent gradient: A = water / methanol 9:1 + 0.1% formic acid, B = acetonitrile + 0.1% formic acid; Gradient: 0–100% B in 2.5 min; Flow rate (ml / min): 0.75.

[0308] Method 6: Spectra were recorded on an electrospray source (polarity: positive and negative ions, capillary: 3.00 kV, cone range: 30 V, extractor: 2.00 V, source temperature: 150 °C, desolvation temperature: 350 °C, cone gas flow: 50 l / h, desolvation gas flow: 650 l / h, mass range: 100-900 Da) and a Waters mass spectrometer (SQD, SQDII single quadrupole mass spectrometer) equipped with a Waters Acquity UPLC: binary pump, heated column compartment, diode-array detector and ELSD detector. Column: Waters UPLC HSS T3, 1.8 μm, 30 × 2.1 mm; Temperature: 60 °C; DAD wavelength range (nm): 210–500; Solvent gradient: A = water + 5% MeOH + 0.05% HC(O)OH; B = acetonitrile + 0.05% HC(O)OH; Gradient: 10–100% B in 1.2 min; Flow rate (ml / min): 0.85.

[0309] The following abbreviations are used in the experimental descriptions: s = singlet, d = doublet, t = triplet, q = quartet, m = multiplet, RT = retention time, min = minutes.

[0310] Example P1: 2-[[2-fluoro-5-(trifluoromethyl)phenyl]methoxy]-6-(methoxymethyl)-5-[4-(5-methyl-1,2,4-oxadiazol-3-yl)piperidine-1-carbonyl]pyridine-3-carbonitrile (compound P1.2): [ka] Step 1: Methyl 5-cyano-6-hydroxy-2-(methoxymethyl)pyridine-3-carboxylate [ka] A mixture of methyl 4-methoxy-3-oxobutanoate (5.00 g, 34.2 mmol) and 1,1-dimethoxy-N,N-dimethyl-methanamine (56.45 mmol, 1.65 equivalents) was stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure. Sodium hydride (2.1 g, 53 mmol, 60% by weight) in paraffin oil was added to a mixture of 2-cyanoacetamide (4.2 g, 50 mmol) in tetrahydrofuran (79 mL). The residue obtained above was then added to the mixture, and the mixture was stirred at room temperature for 18 hours. The reaction mixture was concentrated under reduced pressure, and water was added to the resulting residue. The mixture was then acidified with hydrochloric acid. The deposited solid was collected and washed with water and hexane to obtain 3.6 g of methyl 5-cyano-6-hydroxy-2-(methoxymethyl)pyridine-3-carboxylate as a solid. The reaction mixture was concentrated under reduced pressure. The solid was ... 1 H-NMR [ppm]: 3.37 (s, 3H), 3.79 (s, 3H), 4.77 (s, 2H), 8.47 (s, 1H), 12.43 (broad s, 1H).

[0311] Step 2: Methyl 5-cyano-6-[[2-fluoro-5-(trifluoromethyl)phenyl]methoxy]-2-(methoxymethyl)pyridine-3-carboxylate [ka] To a solution of methyl 5-cyano-6-hydroxy-2-(methoxymethyl)pyridine-3-carboxylate (1.00 g, 4.5 mmol) in DMF (11.3 mL) was added 2-fluoro-5-(trifluoromethyl)-benzyl bromide (197 mg, 6.75 mmol, 1.5 equiv.), followed by potassium carbonate (1.27 g, 9.0 mmol, 2 equiv.). The reaction mixture was stirred at 60 °C for 3 h and cooled to room temperature. The reaction mixture was diluted with water and extracted three times with ethyl acetate. The combined organic extracts were extracted with brine, dried over sodium sulfate, and concentrated under reduced pressure. After removal of the solvent, the residue was purified by combi-flash silica gel (30-40% ethyl acetate / cyclohexane) to give 900 mg of methyl 5-cyano-6-[[2-fluoro-5-(trifluoromethyl)phenyl]methoxy]-2-(methoxymethyl)pyridine-3-carboxylate. 1 H-NMR[ppm]:3.52(s,3H),3.95(s,3H),4.94(s,2H),5.73(s,2H),7.19-7.32(m,1H),7.55-7.75(m,1H),7.99(dd,1H),8.50(s,1H).

[0312] Step 3: 5-cyano-6-[[2-fluoro-5-(trifluoromethyl)phenyl]methoxy]-2-(methoxymethyl)pyridine-3-carboxylic acid [ka] To a solution of methyl 5-cyano-6-[[2-fluoro-5-(trifluoromethyl)phenyl]methoxy]-2-(methoxymethyl)pyridine-3-carboxylate (900 mg, 2.26 mmol) in THF (9 mL) / water (4.5 mL) was added lithium hydroxide (395 mg, 9.04 mmol, 4 equiv.). The reaction mixture was stirred at room temperature until the starting material was completely consumed (monitored by TLC). After removing the solvent under reduced pressure, the residue was dissolved in water and extracted with ethyl acetate (the organic layer was discarded). The aqueous layer was acidified with hydrochloric acid and then extracted three times with ethyl acetate. The combined extracts were dried over sodium sulfate and concentrated to give 750 mg of 5-cyano-6-[[2-fluoro-5-(trifluoromethyl)phenyl]methoxy]-2-(methoxymethyl)pyridine-3-carboxylic acid as a white solid. In DMSO-d6 1 H-NMR[ppm]:3.36(s,3H),4.83(s,2H),5.69(s,2H),7.54(t,1H),7.83-7.90(m,1H),8.13(dd,2.08Hz,1H),8.62(s,1H),13.5(br,s,1H).

[0313] Step 4: 2-[[2-fluoro-5-(trifluoromethyl)phenyl]methoxy]-6-(methoxymethyl)-5-[4-(5-methyl-1,2,4-oxadiazol-3-yl)piperidine-1-carbonyl]pyridine-3-carbonitrile (compound P1.2) [ka] To a solution of 5-cyano-6-[[2-fluoro-5-(trifluoromethyl)phenyl]methoxy]-2-(methoxymethyl)pyridine-3-carboxylic acid (189 mg, 0.49 mmol) in acetonitrile (2.5 mL) was added the hydrochloride salt of 5-methyl-3-(4-piperidyl)-1,2,4-oxadiazole (100 mg, 0.49 mmol), synthesized as described in International Patent Publication No. 2017195703 of Nippon Soda Co., Ltd. Then, COMU coupling reagent (243 mg, 0.54 mmol, 1.1 equiv.) and diisopropyl-ethyl-amine (0.27 mL, 1.47 mmol, 3 equiv.) were added. The reaction mixture was stirred at room temperature for 20 hours and then poured into aqueous NaHCO3 solution. The mixture was extracted three times with ethyl acetate. The aqueous layer was acidified with 2N HCl and extracted three times with ethyl acetate. The combined organic layers were washed with brine, dried over Na2SO4, filtered, and concentrated under reduced pressure. The residue was purified by chromatography to give 100 mg of 2-[[2-fluoro-5-(trifluoromethyl)phenyl]methoxy]-6-(methoxymethyl)-5-[4-(5-methyl-1,2,4-oxadiazol-3-yl)piperidine-1-carbonyl]pyridine-3-carbonitrile as a gum. 1 H-NMR[ppm]:1.86(br d,3H),2.07-2.22(m,1H),2.57(s,3H),3.08(br d,2H),3.16(br s,1H),3.44(s,3H),3.54(br s,1H),4.47(br s,1H),4.54(br s,1H),4.68(br s,1H),5.60(s,2H),7.22(t,1H),7.60-7.65(m,1H),7.75(s,1H),7.87(d,1H).LC-MS(Method 2):RT=1.47min;[M+H] + =534.1.

[0314] The compounds in Table P1 were prepared as described in the above examples or similar methodologies.

[0315] Table P1: Compounds of formula (Ic) [ka] The compounds in Table P1 can be prepared as described in the examples above or similar methodologies. The following abbreviations are used in the tables below: RT = retention time, min = minutes.

[0316] [Table 12-1] [Table 12-2] [Table 12-3]

[0317] Table P2: Compounds of formula (Id) [ka] The compounds in Table P2 can be prepared as described in the examples above or similar methodologies. The following abbreviations are used in the tables below: RT = retention time, min = minutes.

[0318] [Table 13]

[0319] Table P3: Compounds of formula (Ie) [ka] The compounds in Table P3 can be prepared as described in the examples above or similar methodologies. The following abbreviations are used in the tables below: RT = retention time, min = minutes.

[0320] [Table 14]

[0321] Table P4: Compounds of formula (If) [ka] The compounds in Table P4 can be prepared as described in the examples above or similar methodologies. The following abbreviations are used in the tables below: RT = retention time, min = minutes.

[0322] [Table 15]

[0323] Table P5: Compounds of formula (Ig) [ka] The compounds in Table P5 can be prepared as described in the above examples or similar methodologies. The following abbreviations are used in the tables below: RT = retention time, min = minutes.

[0324] [Table 16]

[0325] Table P6: Compounds of formula (Ih) [ka] The compounds in Table P6 can be prepared as described in the examples above or similar methodologies. The following abbreviations are used in the tables below: RT = retention time, min = minutes.

[0326] [Table 17-1] [Table 17-1] [Table 17-3]

[0327] The activity of the composition according to the present invention can be considerably broadened and adapted to the general situation by adding other insecticidally, acaricidally and / or fungicidal active ingredients.The mixture of the compound of formula (I) with other insecticidally, acaricidally and / or fungicidal active ingredients can also have further unexpected advantages, which may be described in a broader sense as synergistic activity.For example, better tolerance by plants, reduced phytotoxicity, insects can be controlled at different stages of their development, or better behavior during their preparation, for example, during grinding or mixing, during their storage, or during their use.

[0328] Suitable additives to the active ingredients herein are, for example, exemplified by the following classes of active ingredients: organophosphorus compounds, nitrophenol derivatives, thioureas, juvenile hormones, formamidines, benzophenone derivatives, urea, pyrrole derivatives, carbamates, pyrethroids, chlorinated hydrocarbons, acylureas, pyridinylmethyleneamino derivatives, macrolides, neonicotinoids and Bacillus thuringiensis preparations.

[0329] The following mixtures of compounds of formula (I) with active substances are preferred (the abbreviation "TX" means "one compound selected from the compounds defined in Tables 1 to 81 and Tables P1 to P6"): An adjuvant selected from the group of substances consisting of petroleum (alternative name) (628) + TX; Abamectin +TX, Acequinocyl +TX, Acetamiprid +TX, Acetoprole +TX, Acrinathrin +TX, Acinonapyr +TX, Afidopiropen +TX, Afoxolaner +TX, Alanycarb +TX, Allethrin +TX, α-Cypermethrin +TX, α-Methrin +TX, Amidoflumet +TX, Aminocarb +TX, Azocyclotine +TX, Bensultap +TX, Benzochimate +TX, Benzpyrimoxane +TX, β-Cyfluthrin +TX, β-Cypermethrin +TX, Bifenazate +TX, Bifenthrin +TX, Binapacryl + TX, Bioallethrin + TX, S-Bioallethrin + TX, Bioresmethrin + TX, Bistrifluron + TX, Brofuranilide + TX, Broflutrinate + TX, Bromophos-ethyl + TX, Buprofezin + TX, Butocarboxim + TX, Cadusafos + TX, Carbaryl + TX, Carbosulfan + TX, Cartap + TX, CAS Number: 1632218-00-8 + TX, CAS Number: 1808115-49-2 + TX, CAS Number: 2032403-97-5 + TX, CAS Number: 2044701-44-0 + TX, CAS Number: 2128 706-05-6+TX, CAS number:2095470-94-1+TX, CAS number:2377084-09-6+TX, CAS number:1445683-71-5+TX, CAS number:2408220-94-8+TX, CAS number:2408220-91-5+TX, CA S number: 1365070-72-9+TX, CAS number: 2171099-09-3+TX, CAS number: 2396747-83-2+TX, CAS number: 2133042-31-4+TX, CAS number: 2133042-44-9+TX, CAS number: 1445684-82 -1+TX, CAS number: 1445684-82-1+TX, CAS number: 1922957-45-6+TX, CAS number: 1922957-46-7+TX, CAS number: 1922957-47-8+TX, CAS number: 1922957-48-9+TX, CAS number: 24 15706-16-8+TX, CAS number: 1594624-87-9+TX, CAS number: 1594637-65-6+TX, CAS number: 1594626-19-3+TX, CAS number: 1990457-52-7+TX, CAS number: 1990457-55-0+TX,CAS No.: 1990457-57-2+TX, CAS No.: 1990457-77-6+TX, CAS No.: 1990457-66-3+TX, CAS No.: 1990457-85-6+TX, CAS No.: 2220132-55-6+TX, CAS No.: 1255091-74-7+TX, CAS No.: 1305319-70-3+TX, CAS No.: 1442448-92-1+TX, CAS No.: RNA (Colorado potato beetle (Leptinotarsa decemLineata)-specific recombinant double-stranded interference (GS2) + TX, CAS No.: 2719848-60-7 + TX, CAS No.: 1956329-03-5 + TX, chlorantraniliprole + TX, chlordane + TX, chlorfenapyr + TX, chlorprallethrin + TX, chromafenozide + TX, clenpirin + TX, cloetocarb + TX, clothianidin + TX, 2-chlorophenyl N-methylcarbamate (CPMC) + TX, cyanofenphos + TX, cyantraniliprole + TX, cyclaniliprole + TX, cyclobutrifluram + TX, cycloprothrin + TX, cycloxapride + TX, cyenopyrafen + TX, cyetopyrafen (or ethopyrafen) + TX, cyflumetofen + TX, cyfluthrin + TX, cyhalodiamide + TX, cyhalothrin + TX, cypermethrin + TX, cyphenothrin + TX, cyprofuranilide + TX, cyromazine + TX, deltamethrin + TX, diafenthiuron + TX, dialifos + TX, dibrom + TX, dichloromezothiaz + TX, diflovidazin + TX, diflubenzuron + TX, dinpropylidaz + TX, dinactin + TX, dinocap + TX, dinotefuran + TX, dioxabenzophos + TX, emamectin (or emamectin benzoate) + TX, empenthrin + TX, ε-monfluorotrin + TX, ε-metofluthrin + TX, Esfenvalerate +TX, Ethion +TX, Ethiprole +TX, Etofenprox +TX, Etoxazole +TX, Fanfur +TX, Fenazaquin +TX, Fenfluthrin +TX, Fenmezodithiaz +TX, Fenitrothion +TX, Fenobucarb +TX, Fenothiocarb +TX, Fenoxycarb +TX, Fenpropathrin +TX, Fenpyroximate +TX, Fensulfothion +TX, Fenthion +TX,Fentin acetate +TX, fenvalerate +TX, fipronil +TX, flometoquin +TX, flonicamid +TX, fluacrypyrim +TX, fluazaindolizine +TX, fluazuron +TX, flubendiamide +TX, flubenzimine +TX, fluchlordiniliprole +TX, flucythrinate +TX, flucycloxuron +TX, flucythrinate +TX, fluensulfone +TX, flufenerim +TX, flufenprox +TX, flufiprole +TX, fluhexafon +TX, flumethrin +TX, fluopyram +TX, Flupentiofenox +TX, Flupyradifurone +TX, Flupirimine +TX, Fluralaner +TX, Fluvalinate +TX, Fluxamethamide +TX, Fosthiazate +TX, γ-cyhalothrin +TX, Guadipyr +TX, Halofenozide +TX, Halfenprox +TX, Heptafluthrin +TX, Hexythiazox +TX, Hydramethylnon +TX, Imicyafos +TX, Imidacloprid +TX, Imiprothrin +TX, Indazapiroximet +TX, Indoxacarb +TX, Iodomethane +TX, Iprodione +TX, Isocyclocera methicillin-resistant Staphylococcus aureus (TX), isothioate-resistant Staphylococcus aureus (TX), ivermectin-resistant Staphylococcus aureus (TX), κ-bifenthrin-resistant Staphylococcus aureus (TX), κ-tefluthrin-resistant Staphylococcus aureus (TX), lambda-cyhalothrin-resistant Staphylococcus aureus (TX), lepimectin-resistant Staphylococcus aureus (TX), lotilaner-resistant Staphylococcus aureus (TX), lufenuron-resistant Staphylococcus aureus (TX), metaflumizone-resistant Staphylococcus aureus (TX), metaldehyde-resistant Staphylococcus aureus (TX), metamexam-resistant Staphylococcus aureus (TX), metham-resistant Staphylococcus aureus (TX), methomyl-resistant Staphylococcus aureus (TX), methoxyfenozide-resistant Staphylococcus aureus (TX), metofluthrin-resistant Staphylococcus aureus (TX), metolcarb-resistant Staphylococcus aureus (TX), mexacarbate-resistant Staphylococcus aureus (TX), milbemectin-resistant Staphylococcus aureus (TX), monfluorotrin-resistant Staphylococcus aureus (TX), nicolamide-resistant Staphylococcus aureus (TX), nicofenuron-resistant Staphylococcus aureus (TX), nitenpyram-resistant Staphylococcus aureus (TX), nithiazine-resistant Staphylococcus aureus (TX), ometoe ate + TX, oxamyl + TX, oxazosulfil + TX, parathion-ethyl + TX, permethrin + TX, fenothrin + TX, phosphocarb + TX, piperonyl butoxide + TX, pirimicarb + TX, pirimiphos-ethyl + TX, pirimiphos-methyl + TX, polyhedrovirus + TX, prallethrin + TX, profenofos + TX, profluthrin + TX, propargite + TX, propetamphos + TX, propoxur + TX, prothiofos + TX, protrifenbut + TX, piflubumid + TX, pymetrozine + TX, pyraclofos + TX,Pyrafluprole +TX, pyridaben +TX, pyridalyl +TX, pyrifluquinazone +TX, pyrimidifen +TX, pyriminostrobin +TX, pyriprole +TX, pyriproxyfen +TX, resmethrin +TX, sarolaner +TX, selamectin +TX, silafluofen +TX, spinetoram +TX, spinosad +TX, spirodiclofen +TX, spiromesifen +TX, spiropydione +TX, spirotetramat +TX, spidoxamat +TX, sulfoxaflor +TX, tebufenozide +TX, tebufenpyrad +TX, tebupirimiphos +TX, tefluthrin +TX, temephos +TX, tetrachlorantraniliprole +TX, tetradifon +TX, tetramethrin +TX, tetramethylfluthrin +TX, tetranactin +TX, tetraniliprole +TX, θ-cypermethrin +TX, thia Cloprid + TX, Thiamethoxam + TX, Thiocyclam + TX, Thiodicarb + TX, Thiofanox + TX, Thiometon + TX, Thiosultap + TX, Tigolaner + TX, Thioxazaphen + TX, Tolfenpyrad + TX, Toxaphene + TX, Tralomethrin + TX, Transfluthrin + TX, Triazamate + TX, Triazophos + TX, Trichlorfon + TX, Trichloronate + TX, Trichlorfon + TX, Trifluenfuronate + TX, Triflumezopyrin + TX, Cyclopyrazoflurane + TX, Z-Cypermethrin + TX, Seaweed extract and fermentation product from Melasse + TX, Seaweed extract and fermentation product from Melasse containing urea + TX, Amino acids + TX, Potassium and molybdenum and EDTA-chelated manganese + TX, Seaweed extract and fermented plant product + TX, Fermented plant products containing seaweed extract and plant hormones +TX, vitamins +TX, EDTA-chelated copper +TX, zinc +TX and iron +TX, azadirachtin +TX, Bacillus aizawai +TX, Bacillus chitinosporus AQ746 (NRRL Accession Number B-21618) +TX, Bacillus firmus +TX, Bacillus kurstaki +TX, Bacillus mycoides AQ726 (NRRL Accession Number B-21664) +TX, Bacillus pumilus (NRRL Accession Number B-30087) +TX, Bacillus pumilus AQ717 (NRRL accession number B-21662) + TX, Bacillus sp. AQ178 (ATCC accession number 53522) + TX, Bacillus sp. AQ175 (ATCC accession number 55608) + TX, Bacillus sp.) AQ177 (ATCC accession number 55609) + TX, Bacillus subtilis unspecified + TX, Bacillus subtilis AQ153 (ATCC accession number 55614) + TX, Bacillus subtilis AQ30002 (NRRL accession number B-50421) + TX, Bacillus subtilis AQ30004 (NRRL accession number B-50455) + TX, Bacillus subtilis AQ713 (NRRL accession number B-21661) + TX, Bacillus subtilis AQ743 (NRRL accession number B-21665) + TX, Bacillus thuringiensis thuringiensis AQ52 (NRRL accession number B-21619) + TX, Bacillus thuringiensis BD#32 (NRRL accession number B-21530) + TX, Bacillus thuringiensis subspec. kurstaki BMP 123 + TX, Beauveria bassiana + TX, D-limonene + TX, granulovirus + TX, harpin + TX, Helicoverpa armigera nucleopolyhedrovirus + TX, Helicoverpa zea nucleopolyhedrovirus + TX, Heliothis virescens nucleopolyhedrovirus + TX, Heliothis punctigera nucleopolyhedrovirus + TX, Metarhizium species spp.) + TX, Muscodor albus 620 (NRRL accession number 30547) + TX, Muscodor roseus A3-5 (NRRL accession number 30548) + TX, Neem tree-based products + TX, Paecilomyces fumosoroseus + TX, Paecilomyces lilacinus + TX, Pasteuria nishizawae + TX, Pasteuria penetrans + TX, Pasteuria ramosa + TX, Pasteuria thornei + TX, Pasteuria usugae usgae + TX, P-cymene + TX, Plutella xylostella granulosis virus + TX, Plutella xylostella nucleopolyhedrovirus + TX, polyhedrovirus + TX, Calystegia japonica + TX, QRD 420 (terpenoid blend) + TX, QRD 452 (terpenoid blend) + TX, QRD 460 (terpenoid blend) + TX, Quillaja saponaria + TX, Rhodococcus globerulus AQ719 (NRRL accession number B-21663) + TX, Spodoptera frugiperda nucleopolyhedrovirus + TX, Streptomyces galbus galbus (NRRL Accession No. 30232) + TX, Streptomyces sp. (NRRL Accession No. B-30145) + TX, terpenoid blend + TX, and Verticillium spp. + TX; an algicide selected from the group of substances consisting of bethoxadin [CCN] + TX, copper dioctanoate (IUPAC name) (170) + TX, copper sulfate (172) + TX, sibutrin [CCN] + TX, dichloron (1052) + TX, dichlorophen (232) + TX, endothal (295) + TX, fentin (347) + TX, hydrated lime [CCN] + TX, nabam (566) + TX, quinoclamine (714) + TX, quinonamide (1379) + TX, simazine (730) + TX, triphenyltin acetate (IUPAC name) (347) and triphenyltin hydroxide (IUPAC name) (347) + TX; an anthelmintic selected from the group of substances consisting of abamectin (1) + TX, crufomate (1011) + TX, cyclobutrifluram + TX, doramectin (alternative name) [CCN] + TX, emamectin (291) + TX, emamectin benzoate (291) + TX, eprinomectin (alternative name) [CCN] + TX, ivermectin (alternative name) [CCN] + TX, milbemycin oxime (alternative name) [CCN] + TX, moxidectin (alternative name) [CCN] + TX, piperazine [CCN] + TX, selamectin (alternative name) [CCN] + TX, spinosad (737) and thiophanate (1435) + TX; an avian repellent selected from the group of substances consisting of chloralose (127) + TX, endrin (1122) + TX, fenthion (346) + TX, pyridin-4-amine (IUPAC name) (23) and strychnine (745) + TX; 1-Hydroxy-1H-pyridine-2-thione (IUPAC name) (1222) + TX, 4-(quinoxalin-2-ylamino)benzenesulfonamide (IUPAC name) (748) + TX, 8-hydroxyquinoline sulfate (446) + TX, bronopol (97) + TX, copper dioctanoate (IUPAC name) (170) + TX, copper hydroxide (IUPAC name) (169) + TX, cresol [CCN] + TX, dichlorophen (232) + TX, dipyrithione (1105) + TX, dodicine (1112) + TX, fenaminosulf (1144) + TX, formaldehyde (404) + TX, hydrargafen (alternative name) [CCN] + TX a fungicide selected from the group of substances consisting of TX, kasugamycin (483) + TX, kasugamycin hydrochloride hydrate (483) + TX, nickel bis(dimethyldithiocarbamate) (IUPAC name) (1308) + TX, nitrapyrin (580) + TX, octhilinone (590) + TX, oxolinic acid (606) + TX, oxytetracycline (611) + TX, potassium hydroxyquinoline sulfate (446) + TX, probenazole (658) + TX, streptomycin (744) + TX, streptomycin sesquisulfate (744) + TX, tecloftalam (766) + TX and thiomersal (alternative name) [CCN] + TX; Adoxophyes orana GV (alternative name) (12) + TX, Agrobacterium radiobacter (alternative name) (13) + TX, Amblyseius spp. (alternative name) (19) + TX, Anagrapha falcifera NPV (alternative name) (28) + TX, Anagrus atomus (alternative name) (29) + TX, Aphelinus abdominalis (alternative name) (33) + TX, Aphidius colemani (alternative name) (34) + TX, Aphidoletes aphidimiza aphidimyza (alternative name) (35) + TX, Autographa californica NPV (alternative name) (38) + TX, Bacillus firmus (alternative name) (48) + TX, Bacillus sphaericus Neide (scientific name) (49) + TX, Bacillus thuringiensis Berliner (scientific name) (51) + TX, Bacillus thuringiensis subsp. aizawai (scientific name) (51) + TX, Bacillus thuringiensis subsp. israelensis) (scientific name) (51) + TX, Bacillus thuringiensis subsp. japonensis (scientific name) (51) + TX, Bacillus thuringiensis subsp. kurstaki (scientific name) (51) + TX, Bacillus thuringiensis subsp. tenebrionis (Bacillus thuringiensis subsp.tenebrionis (scientific name) (51) + TX, Beauveria bassiana (alternate name) (53) + TX, Beauveria brongniartii (alternate name) (54) + TX, Chrysoperla carnea (alternate name) (151) + TX, Cryptolaemus montrouzieri (red ladybird beetle) (alternate name) (178) + TX, Cydia pomonella GV (alternate name) (191) + TX, Dacnusa sibirica (alternate name) (212) + TX, Diglyphus isaea (alternate name) (254) + TX, Encarsia formosa (scientific name) (293) + TX, Eretmocerus eremicus (alternate name) (300) + TX, Helicoverpa zea NPV (alternate name) (431) + TX, Heterorhabditis bacteriophora and H. megidis (alternate name) (433) + TX, Hippodamia convergens (alternate name) (442) + TX, Leptomastix dactylopii (alternate name) (488) + TX, Macrolophus caliginosus (alternate name) (491) + TX, Mamestra brassicae NPV (alternate name) (494) + TX, Metaphycus helvolus (alternate name) (522) + TX, Metarhizium anisopliae var. acridum (scientific name) (523) + TX, Metarhizium anisopliae var. anisopliae (scientific name) (523) + TX, Neodiprion sertifer NPV and N. leconti (N.lecontei NPV (alternate name) (575) + TX, Orius spp. (alternate name) (596) + TX, Paecilomyces fumosoroseus (alternate name) (613) + TX, Phytoseiulus persimilis (alternate name) (644) + TX, Spodoptera exigua multicapsid nuclear polyhedrosis virus (scientific name) (741) + TX, Steinernema bibionis (alternate name) (742) + TX, Steinernema carpocapsae (alternate name) (742) + TX, Steinernema felziae feltiae (alternate name) (742) + TX, Steinernema glaseri (alternate name) (742) + TX, Steinernema riobrave (alternate name) (742) + TX, Steinernema riobravis (alternate name) (742) + TX, Steinernema scapterisci (alternate name) (742) + TX, Steinernema spp. (alternate name) (742) + TX, Trichogramma spp. (alternate name) (826) + TX, Typhlodromus occidentalis a biological agent selected from the group of substances consisting of Verticillium lecanii (alternative name) (848) + TX; a soil sterilant selected from the group of substances consisting of iodomethane (IUPAC name) (542) and methyl bromide (537) + TX; an antisterilant selected from the group of substances consisting of Afolate [CCN] + TX, Visadyl (alternative name) [CCN] + TX, Busulfan (alternative name) [CCN] + TX, Diflubenzuron (250) + TX, Zimatif (alternative name) [CCN] + TX, Hemel [CCN] + TX, Hempa [CCN] + TX, Metepa [CCN] + TX, Methiotepa [CCN] + TX, Methyl Afolate [CCN] + TX, Morzide [CCN] + TX, Penfluron (alternative name) [CCN] + TX, Tepa [CCN] + TX, Thiohempa (alternative name) [CCN] + TX, Thiotepa (alternative name) [CCN] + TX, Tretamine (alternative name) [CCN] and Uredepa (alternative name) [CCN] + TX; (E)-Deca-5-en-1-yl acetate and (E)-dec-5-en-1-ol (IUPAC name) (222) + TX, (E)-tridec-4-en-1-yl acetate (IUPAC name) (829) + TX, (E)-6-methylhept-2-en-4-ol (IUPAC name) (541) + TX, (E,Z)-tetradec-4,1 0-Dien-1-yl acetate (IUPAC name) (779) + TX, (Z)-Dodec-7-en-1-yl acetate (IUPAC name) (285) + TX, (Z)-Hexadec-11-enal (IUPAC name) (436) + TX, (Z)-Hexadec-11-en-1-yl acetate (IUPAC name) (437) + TX, (Z)-Hex Sadec-13-en-11-yn-1-yl acetate (IUPAC name) (438) + TX, (Z)-Icos-13-en-10-one (IUPAC name) (448) + TX, (Z)-tetradec-7-en-1-al (IUPAC name) (782) + TX, (Z)-tetradec-9-en-1-ol (IUPAC name) (783) + TX, ( Z)-Tetradeca-9-en-1-yl acetate (IUPAC name) (784) + TX, (7E,9Z)-dodeca-7,9-dien-1-yl acetate (IUPAC name) (283) + TX, (9Z,11E)-tetradeca-9,11-dien-1-yl acetate (IUPAC name) (780) + TX, (9Z,12E)-tetradeca-9,12-dien-1-yl acetate (IUPAC name) (781) + TX, 14-methyloctadec-1-ene (IUPAC name) (545) + TX, 4-methylnonan-5-ol and 4-methylnonan-5-one (IUPAC name) (544) + TX, α-multistriatin (alternative name) [CCN] + TX, Brevicomin (alternative name) [CCN] + TX, Codlerua (alternative name) [CCN] + TX, Codlemone (alternative name) (167) + TX, Curua ( (alternative name) (179) + TX, disparlure (277) + TX, dodec-8-en-1-yl acetate (IUPAC name) (286) + TX, dodec-9-en-1-yl acetate (IUPAC name) (287) + TX, dodec-8 + TX, 10-dien-1-yl acetate (IUPAC name) (284) + TX, dominicalure (alternative name) [CCN] + TX, ethyl 4-methyloctanoate (IUPAC name) (317) + TX, eugenol (alternative name) ) [CCN] + TX, Frontalin (alternate name) [CCN] + TX, Gossip Lua (alternate name) (420) + TX, Grand Lua (421) + TX, Grand Lua I (alternate name) (421) + TX, Grand Lua II (alternate name) (421) + TX, Grand Lua III (alternate name) (421) + TX, Grand Lua IV (alternate name) (421) + TX, Hexalua [CCN] + TX, Ipsdienol (alternate name) [CCN] + TX, Ipsenol (alternate name [ CCN] + TX, Japonirua (alternative name) (481) + TX, Lineatin (alternative name) [CCN] + TX, Litirua (alternative name) [CCN] + TX, Lupulua (alternative name) [CCN] + TX, Medurua [CCN] + TX, Megatomoic acid (alternative name) [CCN] + TX, Methyleugenol (alternative name) (540) + TX, Muscalua (563) + TX, Octadeca-2,13-dien-1-yl acetate (IUPAC name) (588) + TX, Octadeca-3,13-Dien-1-yl acetate (IUPAC name) (589) + TX, Olfrulure (alternative name) [CCN] + TX, Orictalure (alternative name) (317) + TX, Ostramon (alternative name) [CCN] + TX, Siglua [CCN] + TX, Soldigin (alternative name) (736) + TX, Sulcatol (alternative name) [CCN] + TX, Tetradec-11-en-1-yl acetate (IU an insect pheromone selected from the group of substances consisting of Trimedulla (PAC name) (785) + TX, Trimedulla (839) + TX, Trimedulla A (alternate name) (839) + TX, Trimedulla B1 (alternate name) (839) + TX, Trimedulla B2 (alternate name) (839) + TX, Trimedulla C (alternate name) (839) and Trunk-call (alternate name) [CCN] + TX; an insect repellent selected from the group of substances consisting of 2-(octylthio)ethanol (IUPAC name) (591) + TX, butopyronoxyl (933) + TX, butoxy(polypropylene glycol) (936) + TX, dibutyl adipate (IUPAC name) (1046) + TX, dibutyl phthalate (1047) + TX, dibutyl succinate (IUPAC name) (1048) + TX, diethyltoluamide [CCN] + TX, dimethylcarbate [CCN] + TX, dimethyl phthalate [CCN] + TX, ethyl hexanediol (1137) + TX, hexamide [CCN] + TX, methoquin-butyl (1276) + TX, methylneodecanamide [CCN] + TX, oxamate [CCN] and picaridin [CCN] + TX; Bis(tributyltin)oxide (IUPAC name) (913) + TX, Bromoacetamide [CCN] + TX, Calcium arsenate [CCN] + TX, Cloethocarb (999) + TX, Copper acetarsenite [CCN] + TX, Copper sulfate (172) + TX, Fentin (347) + TX, Ferric phosphate (IUPAC name) (352) + TX, Metaldehyde (518) + TX, Methiocarb (530) + TX, Niclosamide (576) + TX, Niclosamide-olamine (576) + TX, Pentachloroethylene (Phenylalanine) a molluscicide selected from the group of substances consisting of: chlorophenol (623) + TX, sodium pentachlorophenoxide (623) + TX, thazimcarb (1412) + TX, thiodicarb (799) + TX, tributyltin oxide (913) + TX, triphenmorph (1454) + TX, trimethacarb (840) + TX, triphenyltin acetate (IUPAC name) (347) and triphenyltin hydroxide (IUPAC name) (347) + TX, pyriprole [394730-71-3] + TX; AKD-3088 (compound code) + TX, 1,2-dibromo-3-chloropropane (IUPAC / Chemical Abstracts Name) (1045) + TX, 1,2-dichloropropane (IUPAC / Chemical Abstracts Name) (1062) + TX, 1,2-dichloropropane and 1,3-dichloropropene (IUPAC Name) (1063) + TX, 1,3-dichloropropene (233) + TX, 3,4-dichlorotetrahydrothiophene 1,1-dioxide (IUPAC / Chemical Abstracts Name) (Plastic name) (1065) + TX, 3-(4-chlorophenyl)-5-methylrhodanine (IUPAC name) (980) + TX, 5-methyl-6-thioxo-1,3,5-thiadiazinan-3-ylacetic acid (IUPAC name) (1286) + TX, 6-isopentenylaminopurine (alternative name) (210) + TX, abamectin (1) + TX, acetoprole [CCN] + TX, alanycarb (15) + TX, aldicarb (16) + TX, aldoxicarb (863) + TX, AZ60541 (compound code) + TX, benclotiaz [CCN] + TX, benomyl (62) + TX, butylpyridaben (alternative name) + TX, cadusafos (109) + TX, carbofuran (118) + TX, carbon disulfide (945) + TX, carbosulfan (119) + TX, chloropicrin (141) + TX, chlorpyrifos (145) + TX, cloetocarb (999) + TX, cyclobutrifluram + TX, cytokinin (alternative name) (210) + T X, Dazomet (216) + TX, DBCP (1045) + TX, DCIP (218) + TX, Diamidaphos (1044) + TX, Diclofenthion (1051) + TX, Dicrifos (alternative name) + TX, Dimethoate (262) + TX, Doramectin (alternative name) [CCN] + TX, Emamectin (291) + TX, Emamectin Benzoate (291) + TX, Eprinomectin (alternative name) [CCN] + TX, Ethoprophos (312) + TX, Ethyl Dibromide len (316) + TX, fenamiphos (326) + TX, fenpyrad (alternative name) + TX, fensulfothion (1158) + TX, fosthiazate (408) + TX, fostietan (1196) + TX, furfural (alternative name) [CCN] + TX, GY-81 (development code) (423) + TX, heterophos [CCN] + TX, iodomethane (IUPAC name) (542) + TX, isamidophos (1230) + TX, isazophos (1231) + TX, ebe Lumectin (alternative name) [CCN] + TX, Kinetin (alternative name) (210) + TX, Mecarfone (1258) + TX, Metam (519) + TX, Metam-potassium (alternative name) (519) + TX, Metam-sodium (519) + TX, Methyl bromide (537) + TX, Methyl isothiocyanate (543) + TX, Milbemycin oxime (alternative name) [CCN] + TX, Moxidectin (alternative name) [CCN] + TX, Myrotheciumverrucaria) Composition (alternative name) (565) + TX, NC-184 (compound code) + TX, Oxamyl (602) + TX, Phorate (636) + TX, Phosphamidon (639) + TX, Phosphocarb [CCN] + TX, Cebufos (alternative name) + TX, Selamectin (alternative name) [CCN] + TX, Spinosad (737) + TX, Terbam (alternative name) + TX, Terbufos (773) + TX, Tetrachlorothiophene (IU a nematicide selected from the group of substances consisting of PAC / Chemical Abstracts Name) (1422) + TX, Thiafenox (alternative name) + TX, Thionazine (1434) + TX, Triazophos (820) + TX, Triazuron (alternative name) + TX, Xylenol [CCN] + TX, YI-5302 (compound code) and Zeatin (alternative name) (210) + TX, Fluensulfone [318290-98-1] + TX, Fluopyram + TX; a nitrification inhibitor selected from the group of substances consisting of potassium ethylxanthate [CCN] and nitrapyrin (580) + TX; a plant activator selected from the group of substances consisting of acibenzolar (6) + TX, acibenzolar-S-methyl (6) + TX, probenazole (658) and Reynoutria sachalinensis extract (alternative name) (720) + TX; 2-Isovalerylindan-1,3-dione (IUPAC name) (1246) + TX, 4-(quinoxalin-2-ylamino)benzenesulfonamide (IUPAC name) (748) + TX, α-chlorohydrin [CCN] + TX, aluminum phosphide (640) + TX, antu (880) + TX, arsenic trioxide (882) + TX, barium carbonate (891) + TX, bisthiosemi (912) + TX, brodifacoium (89) + TX, bromadiolone (including α-bromadiolone) +TX, Bromethalin (92) +TX, Calcium cyanide (444) +TX, Chloralose (127) +TX, Chlorophacinone (140) +TX, Cholecalciferol (alternative name) (850) +TX, Coumacrol (1004) +TX, Coumafuryl (1005) +TX, Coumatetralyl (175) +TX, Crimidine (1009) +TX, Difenacoum (246) +TX, Difethialone (249) +TX, Diphacinone (273) +TX, Ergocalciferol (301) +TX, F Locumafen (357) + TX, Fluoroacetamide (379) + TX, Flupropaline (1183) + TX, Flupropaline Hydrochloride (1183) + TX, γ-HCH (430) + TX, HCH (430) + TX, Hydrogen Cyanide (444) + TX, Iodomethane (IUPAC name) (542) + TX, Lindane (430) + TX, Magnesium Phosphide (IUPAC name) (640) + TX, Methyl Bromide (537) + TX, Norbormide (1318) + TX, Fosacetim (1336) + TX, Fosacetim a rodenticide selected from the group of substances consisting of sphingosine (IUPAC name) (640) + TX, phosphorus [CCN] + TX, pindone (1341) + TX, potassium arsenite [CCN] + TX, pyrinuron (1371) + TX, sciliroside (1390) + TX, sodium arsenite [CCN] + TX, sodium cyanide (444) + TX, sodium fluoroacetate (735) + TX, strychnine (745) + TX, thallium sulfate [CCN] + TX, warfarin (851) and zinc phosphide (640) + TX; a synergist selected from the group of substances consisting of 2-(2-butoxyethoxy)ethyl piperonylate (IUPAC name) (934) + TX, 5-(1,3-benzodioxol-5-yl)-3-hexylcyclohex-2-enone (IUPAC name) (903) + TX, farnesol and nerolidol (alternative names) (324) + TX, MB-599 (development code) (498) + TX, MGK 264 (development code) (296) + TX, piperonyl butoxide (649) + TX, piperotal (1343) + TX, propyl isomer (1358) + TX, S421 (development code) (724) + TX, sesamex (1393) + TX, sesamolin (1394) and sulfoxide (1406) + TX; an animal repellent selected from the group of substances consisting of anthraquinone (32) + TX, chloralose (127) + TX, copper naphthenate [CCN] + TX, copper oxychloride (171) + TX, diazinon (227) + TX, dicyclopentadiene (chemical name) (1069) + TX, guazatine (422) + TX, guazatine acetate (422) + TX, methiocarb (530) + TX, pyridin-4-amine (IUPAC name) (23) + TX, thiram (804) + TX, trimethacarb (840) + TX, zinc naphthenate [CCN], and ziram (856) + TX; a virucidal agent selected from the group of substances consisting of Imanin (alternative name) [CCN] and Ribavirin (alternative name) [CCN] + TX; a wound protectant selected from the group of substances consisting of mercuric oxide (512) + TX, octilinone (590) and thiophanate-methyl (802) + TX; 1,1-bis(4-chloro-phenyl)-2-ethoxyethanol + TX, 2,4-dichlorophenylbenzenesulfonate + TX, 2-fluoro-N-methyl-N-1-cinnamaldehyde + TX, 4-chlorophenyl phenyl sulfone + TX, acetoprole + TX, aldoxicarb + TX, amidithione + TX, amidothioate + TX, amiton + TX, amiton hydrogen oxalate + TX, amitraz + TX, alamite + TX, arsenic trioxide + TX, azobenzene + TX, azotoate + TX, benomyl + TX, benoxafos + TX, benzyl ammonium Benzoate +TX, Bixafen +TX, Brofenvalerate +TX, Bromocyclen +TX, Bromophos +TX, Bromopropylate +TX, Buprofezin +TX, Butocarboxim +TX, Butoxycarboxim +TX, Butylpyridaben +TX, Calcium polysulfate +TX, Camphechlor +TX, Carbanolate +TX, Carbophenothion +TX, Cymiazole +TX, Thiomethionate +TX, Chlorbeside +TX, Chlordimeform +TX, Chlordimeform hydrochloride +TX, Chlorphenetole +TX, Chlorfenson +T X, chlorphenesulfide +TX, chlorobenzilate +TX, chlormebform +TX, chloromethiuron +TX, chloropropylate +TX, chlorthiophos +TX, cinerin I +TX, cinerin II +TX, cinerinth +TX, closantel +TX, coumaphos +TX, crotamiton +TX, crotoxyphos +TX, khuraeb +TX, cyanthoate +TX, DCPM +TX, DDT +TX, demefion +TX, demefion-O +TX, demefion-S +TX, demeton-methyl +TX, demeton-O +TX, demeton-O-methyl +TX , Demeton-S+TX, Demeton-S-methyl+TX, Demeton-S-methylsulfone+TX, Dichlofluanid+TX, Dichlorvos+TX, Dicrifos+TX, Dienochlor+TX, Dimefox+TX, Zinex+TX, Zinex-diclexin+TX, Dinocap-4+TX, Dinocap-6+TX, Dinocton+TX, Dinopenton+TX, Dinosulfone+TX, Dinotervone+TX, Dioxathion+TX, Diphenylsulfone+TX, Disulfiram+TX, DNOC+TX, Dofenapine+TX, Doramectin+TX, Endothion+TX,Epirinomectin +TX, Ethoate Methyl +TX, Etrimphos +TX, Fenazaflor +TX, Fenbutatin Oxide +TX, Fenothiocarb +TX, Fenpyrad +TX, Fenpyroximate +TX, Fenpyrazamine +TX, Fenson +TX, Fentrifanil +TX, Flubenzimine +TX, Flucycloxuron +TX, Fluenethyl +TX, Fluorobenside +TX, FMC1137 +TX, Formetanate +TX, Formetanate Hydrochloride +TX, Formoparanate +TX, γ-HCH +TX, Gliodin +TX, Halfe Amprox + TX, Hexadecylcyclopropanecarboxylate + TX, Isocarbophos + TX, Jasmolin I + TX, Jasmolin II + TX, Jodofenphos + TX, Lindane + TX, Malonoben + TX, Mecarbam + TX, Mefosfolan + TX, Mesulfen + TX, Methacrifos + TX, Methyl Bromide + TX, Metolcarb + TX, Mexacarbate + TX, Milbemycin oxime + TX, Mipafox + TX, Monocrotophos + TX, Morphothion + TX, Moxidectin + TX, Naled + TX, 4-chloro-2-(2-chloro-2-methyl) (6-iodo-3-pyridyl)methoxy)pyridazin-3-one + TX, Nifluridide + TX, Nikkomycin + TX, Nitrilacarb + TX, Nitrilacarb 1:1 zinc chloride complex + TX, Omethoate + TX, Oxydeprophos + TX, Oxydisulfoton + TX, pp'-DDT + TX, Parathion + TX, Permethrin + TX, Fenkapton + TX, Phosalone + TX, Phosphorane + TX, Phosphamidon + TX, Polychloroterpenes + TX, Polynactin + TX, Proclonol + TX, Promacyl + TX, Propoxylic Acid Sul+TX, Protidathion+TX, Protoate+TX, Pyrethrin I+TX, Pyrethrin II+TX, Pyrethrin+TX, Pyridaphenthion+TX, Pirimitate+TX, Quinalphos+TX, Quinthiofos+TX, R-1492+TX, Phosglycine+TX, Rotenone+TX, Schladan+TX, Cebufos+TX, Selamectin+TX, Sofamid+TX, SSI-121+TX, Sulfiram+TX, Sulfuramide+TX, Sulfotep+TX, Sulfur+TX, Diflobidazin+TX, τ-Fulvalinate+TX, TEPP+TX, Thelbam+TX,Tetradifon + TX, Tetrasul + TX, Thiafenox + TX, Thiocarboxim + TX, Thiofanox + TX, Thiometon + TX, Thioquinox + TX, Thuringiensin + TX, Triamiphos + TX, Triatene + TX, Triazophos + TX, Triazuron + TX, Trifenofos + TX, Trinactin + TX, Vamidothion + TX, Vaniliprole + TX, Bethoxadin + TX, Copper dioctanoate + TX , Copper sulfate + TX, Sibutrin + TX, Dichlorn + TX, Dichlorophen + TX, Endothal + TX, Fentin + TX, Slaked lime + TX, Nabam + TX, Quinoclamine + TX, Quinoneamide + TX, Simazine + TX, Triphenyltin acetate + TX, Triphenyltin hydroxide + TX, Crufomate + TX, Piperazine + TX, Thiophanate + TX, Chloralose + TX, Fenthion + TX, Pyridin-4-amine + T X, strychnine + TX, 1-hydroxy-1H-pyridine-2-thione + TX, 4-(quinoxalin-2-ylamino)benzenesulfonamide + TX, 8-hydroxyquinoline sulfate + TX, bronopol + TX, copper hydroxide + TX, cresol + TX, dipyrithione + TX, doditin + TX, fenaminosulf + TX, formaldehyde + TX, hydralgafen + TX, kasugamycin + TX, kasugamycin hydrochloride hydrate + TX, nickel bis(dimethyldithiocarbamate) + TX, nitrapyrin + TX, octhilinone + TX, oxolinic acid + TX, oxytetracycline + TX, potassium hydroxyquinoline sulfate + TX, probenazole + TX, streptomycin + TX, streptomycin sesquisulfate + TX, tecloftalam + TX, thiomersal + TX, Adoxophyes orana GV+TX, Agrobacterium radiobacter+TX, Amblyseius spp.+TX, Anagrapha falcifera NPV+TX, Anagrahus atomus+TX, Aphelinus abdominalis+TX, Aphidius colemani+TX,Aphidoletes aphidimyza + TX, Autographa californica NPV + TX, Bacillus sphaericus Neide + TX, Beauveria brongniartii + TX, Chrysoperla carnea + TX, Cryptolaemus montrouzieri + TX, Codling moth (Cydia pomonella GV) + TX, Dacnusa sibirica + TX, Diglyphus isaea + TX, Encarsia formosa + TX, Eretmocerus eremicus + TX, Heterorhabditis bacteriophora and H. megidis + TX, Hippodamia convergens + TX, Leptomastix dactylopii + TX, Macrolophus caliginosus + TX, Mamestra brassicae NPV + TX, Metaphycus helvolus + TX, Metarhizium anisopliae var. acridum + TX, Metarhizium anisopliae var. anisopliae + TX, Neodiprion sertifer NPV and N. lecontei NPV + TX, Orius spp. + TX, Paecilomyces fumosoroseus + TX, Phytoseiulus persimilis + TX, Steinernema bibionis + TX, Steinernema carpocapsae + TX, Steinernema feltiae + TX, Steinernema glaseri + TX, Steinernema riobrave + TX, Steinernema riobravis + TX, Steinernema scapterisci + TX, Steinernema spp. + TX, Trichogramma spp. + TX, Typhlodromus occidentalis + TX, Verticillium lecanii) + TX, apholate + TX, Visadil + TX, busulfan + TX, Dimatif + TX, Hemel + TX, Hempa + TX, Metepa + TX, Methiotepa + TX, methyl apholate + TX, Molzide + TX, Penfluron + TX, Tepa + TX, Thiohempa + TX, Thiotepa + TX, Tretamine + TX, Uredepa + TX, (E)-dec-5-en-1-yl acetate + (E)-dec-5-en-1-ol + TX, (E)-tridec-4-en-1-yl acetate + TX, (E)-6-methylhept-2-en-4-ol + TX, (E,Z)-tetradec-4,10-dien-1-yl acetate + TX, (Z)-Dodec-7-en-1-yl acetate + TX, (Z)-hexadec-11-enal + TX, (Z)-hexadec-11-en-1-yl acetate + TX, (Z)-hexadec-13-en-11-yn-1-yl acetate + TX, (Z)-icosa-13-en-10-one + TX, (Z)-tetradec-7-en-1-al + TX, (Z)-tetradec-9-en-1-ol + TX, (Z)-tetradec-9-en-1-yl acetate + TX, (7E,9Z)-dodeca-7,9-dien-1-yl acetate + TX, (9Z,11E)-tetradec-9,11-dien-1-yl acetate + TX,(9Z,12E)-Tetradeca-9,12-dien-1-yl acetate + TX, 14-methyloctadec-1-ene + TX, 4-methylnonan-5-ol + 4-methylnonan-5-one + TX, α-multistriatin + TX, Brevicomin + TX, Codrelure + TX, Codremon + TX, Querule + TX, Disparlure + TX, Dodec-8-en-1-yl acetate + TX, Dodec-9-en-1-yl acetate + TX, Dodec-8 + TX, 10-dien-1-yl acetate + TX, Dominicalure + TX, Ethyl 4-methyloctanoate +TX, Eugenol +TX, Frontalin +TX, Grandlure +TX, Grandlure I +TX, Grandlure II +TX, Grandlure III +TX, Grandlure IV +TX, Hexalure +TX, Ipsdienol +TX, Ipsenol +TX, Japonilure +TX, Lineatin +TX, Littlea +TX, Looplure +TX, Medlure +TX, Megatomoic acid +TX, Methyleugenol +TX, Muscalure +TX, Octadeca-2,13-dien-1-yl acetate +TX, Octadeca-3,13-dien-1-yl acetate +TX, Olfra Lua + TX, Orictalua + TX, Ostramon + TX, Siglua + TX, Soldigin + TX, Sulcatol + TX, Tetradec-11-en-1-yl acetate + TX, Trimedlure + TX, Trimedlure A + TX, Trimedlure B1 + TX, Trimedlure B2 + TX, Trimedlure C + TX, Trunc-call + TX, 2-(Octylthio)-ethanol + TX, Butapyronoxyl + TX, Butoxy(Polypropylene Glycol) + TX, Dibutyl Adipate + TX, Dibutyl Phthalate + TX, Dibutyl Succinate + T X, diethyltoluamide + TX, dimethylcarbate + TX, dimethylphthalate + TX, ethylhexanediol + TX, hexamide + TX, methoquin-butyl + TX, methylneodecanamide + TX, oxamate + TX, picaridin + TX, 1-dichloro-1-nitroethane + TX, 1,1-dichloro-2,2-bis(4-ethylphenyl)-ethane + TX, 1,2-dichloropropane + 1,3-dichloropropene + TX, 1-bromo-2-chloroethane + TX, 2,2,2-trichloro-1-(3,4-dichloro-phenyl)ethyl acetate + TX,2,2-Dichlorovinyl 2-ethylsulfinylethyl methyl phosphate + TX, 2-(1,3-dithiolan-2-yl)phenyl dimethyl carbamate + TX, 2-(2-butoxyethoxy)ethyl thiocyanate + TX, 2-(4,5-dimethyl-1,3-dioxolan-2-yl)phenyl methyl carbamate + TX, 2-(4-chloro-3,5-xylyloxy)ethanol + TX, 2-chlorovinyl diethyl phosphate + TX, 2-imidazolidone + TX, 2-isovalerylindan-1,3-dione + TX, 2-methyl(prop-2-ynyl)aminophenyl methyl carbamate + TX, 2-thiocyanatoethyl laureth acetone + TX, 3-bromo-1-chloroprop-1-ene + TX, 3-methyl-1-phenylpyrazol-5-yldimethylcarbamate + TX, 4-methyl(prop-2-ynyl)amino-3,5-xylylmethylcarbamate + TX, 5,5-dimethyl-3-oxocyclohex-1-enyldimethylcarbamate + TX, acetione + TX, acrylonitrile + TX, aldrin + TX, allosamidin + TX, alixycarb + TX, α-ecdysone + TX, aluminum phosphide + TX, aminocarb + TX, anabasine + TX, atidathion + TX, azamethiphos + TX, Bacillus thuringiensis (Bacillus thuringiensis) δ-endotoxin +TX, barium hexafluorosilicate +TX, barium polysulfide +TX, bartholin +TX, Bayer 22 / 190 +TX, Bayer 22408 +TX, β-cyfluthrin +TX, β-cypermethrin +TX, bioethanometrin +TX, biopermethrin +TX, bis(2-chloroethyl) ether +TX, sodium borate +TX, bromfenvinphos +TX, bromo-DDT +TX, bufencarb +T X, butacarb + TX, butathiophos + TX, butonate + TX, calcium arsenate + TX, calcium cyanide + TX, carbon disulfide + TX, carbon tetrachloride + TX, cartap hydrochloride + TX, sevadin + TX, chlorbicyclen + TX, chlordane + TX, chlordecone + TX, chloroform + TX, chloropicrin + TX, chlorphoxim + TX, chlorprazophos + TX, cis-resmethrin + TX, cismethrin + TX, clocitrin + TX, copper acetoarsenite + TX,Copper arsenate + TX, copper oleate + TX, coumitoate + TX, cryolite + TX, CS708 + TX, cyanofenphos + TX, cyanophos + TX, cyclethrin + TX, cythioate + TX, d-tetramethrin + TX, DAEP + TX, dazomet + TX, decarbofuran + TX, diamidaphos + TX, dikapton + TX, dichlorophenthion + TX, dicresyl + TX, dicyclanil + TX, dieldrin + TX, diethyl 5-methylpyrazol-3-yl phosphate + TX, dilol + TX, dimefluthrin + TX, dimethane + TX, dimethryn + TX, dimethylvinphos + TX, dimethyllan + TX, dinoprop + TX, dinosam + TX, dinoseb + TX, diofenolan + TX, dioxabenzophos + TX, dicyclophos + TX, DSP + TX, ecdysterone + TX, EI 1642+TX, EMPC+TX, EPBP+TX, Ethaphos+TX, Ethiofencarb+TX, Ethyl formate+TX, Ethylene dibromide+TX, Dichloroethane+TX, Ethylene oxide+TX, EXD+TX, Fenchlorphos+TX, Fenetacarb+TX, Fenitrothion+TX, Fenoxacrim+TX, Fenpyrithrin+TX, Fensulfothion+TX, Fenthion-ethyl+TX, Flucofuron+TX, Fosmetilan+TX, Fospirate+TX, Fostietan+TX, Furathiocarb+TX, Frethrin+TX, Guazatine+TX, Guazatine acetate+TX, Sodium tetrathiocarboxylate+TX, Halfenprox+TX, HCH+TX, HEOD+TX, Heptachlor +TX, Heterofos +TX, HHDN +TX, Hydrogen cyanide +TX, Hikincarb +TX, IPSP +TX, Isazophos +TX, Isobenzan +TX, Isodrin +TX, Isofenphos +TX, Isolane +TX, Isoprothiolane +TX, Isoxathion +TX, Juvenile hormone I +TX, Juvenile hormone II +TX, Juvenile hormone III +TX, Kelevan +TX, Kinoprene +TX, Lead arsenate +TX, Leptophos +TX, Lilimphos +TX, Ritidathion +TX, m-Cumenylmethylcarbamate +TX, Magnesium phosphide +TX, Magidox +TX, Mecarfone +TX, Menasone +TX, Mercurous chloride +TX, Mesulfenphos +TX, Metam +TX, Metam-potassium +TX, Metam-sodium +TX,Methanesulfonyl fluoride + TX, Metocrotophos + TX, Methoprene + TX, Methotrin + TX, Methoxychlor + TX, Methyl isothiocyanate + TX, methyl chloroform + TX, methylene chloride + TX, methoxadiazone + TX, Mirex + TX, naphthalophos + TX, naphthalene + TX, NC-170 + TX, nicotine + TX, nicotine sulfate + TX, nithiazine + TX, nornicotine + TX, O-5-dichloro-4-iodophenyl O-ethyl ethyl phosphonothioate + TX, O,O-diethyl O-4-methyl-2-oxo-2H-chromen-7-yl phosphorothioate + TX, O,O-diethyl O-6-methyl-2-propylpyrimidin-4-yl Phosphorothioate + TX, O,O,O',O'-Tetrapropyldithiopyrophosphate + TX, Oleic acid + TX, para-dichlorobenzene + TX, parathion-methyl + TX, pentachlorophenol + TX, pentachlorophenyl laurate + TX, PH60-38 + TX, fenkapton + TX, phosnichlor + TX, phosphine + TX, phoxim-methyl + TX, pyrimetaphos + TX, polychlorodicyclopentadiene isomers + TX, potassium arsenite + TX, potassium thiocyanate + TX, precocene I + TX, precocene II + TX, Precocene III + TX, Pyrimidophos + TX, Profluthrin + TX, Promecarb + TX, Prothiofos + TX, Pyrazophos + TX, Pyresmethrin + TX, Cassia + TX, Quinalphos-methyl + TX, Quinothione + TX, Lafoxanide + TX, Resmethrin + TX, Rotenone + TX, Kadethrin + TX, Riania + TX, Ryanodine + TX, Sabadila + TX, Shradan + TX, Cebufos + TX, SI-0009 + TX, Tiapronil + TX, Sodium arsenite + TX, Sodium cyanide + TX, Sodium fluoride + TX, Hexafluoroke Sodium selenate +TX, pentachlorophenoxide sodium salt +TX, sodium selenate +TX, sodium thiocyanate +TX, sulcofuron +TX, sulcofuron-sodium +TX, sulfuryl fluoride +TX, sulprofos +TX, tar oil +TX, thionazine +TX, TDE +TX, tebupirimfos +TX, temephos +TX, telallethrin +TX, tetrachloroethane +TX, cyclofos +TX, thiocyclam +TX, thiocyclam hydrogen oxalate +TX, thionazine +TX, thiosultap +TX, thiosultap-sodium +TX,Tralomethrin + TX, transpermethrin + TX, triazamate + TX, trichlormethaphos-3 + TX, trichloronat + TX, trimethacarb + TX, tolprocarb + TX, triclopiricarb + TX, triplen + TX, veratridine + TX, veratrine + TX, XMC + TX, zetamethrin + TX, zinc phosphide + TX, zolaprofos + TX, meperfluthrin + TX, tetramethylfluthrin + TX, bis(tributyltin) oxide + TX, bromoacetamide + TX, ferric phosphate + TX, niclosamide-olamine + TX, tributyltin oxide + TX, pyrimidine Luf + TX, Trifenmorph + TX, 1,2-Dibromo-3-chloropropane + TX, 1,3-Dichloropropene + TX, 3,4-Dichlorotetrahydrothiophene 1,1-Dioxide + TX, 3-(4-Chlorophenyl)-5-methylrhodanine + TX, 5-Methyl-6-thioxo-1,3,5-thiadiazinan-3-ylacetic acid + TX, 6-Isopentenylaminopurine + TX, Anicifluprine + TX, Benclotiaz + TX, Cytokinin + TX, DCIP + TX, Lufural + TX, Isamidophos + TX, Kinetin + TX, Myrothecium verrucaria Composition + TX, Tetrachlorothiophene + TX, Xylenol + TX, Zeatin + TX, Potassium Ethylxanthate + TX, Acibenzolar + TX, Acibenzolar-S-methyl + TX, Reynoutria sachalinensis) extract +TX, α-chlorohydrin +TX, Anz +TX, barium carbonate +TX, bisthiosemi +TX, brodifacoum +TX, bromadiolone +TX, bromethalin +TX, chlorophacinone +TX, cholecalciferol +TX, coumachlor +TX, coumafuryl +TX, coumatetralyl +TX, crimidine +TX, difenacoum +TX, difethialone +TX, diphacinone +TX, ergocalciferol +TX, flocoumafen +TX, fluoroacetamide +TX, flupropazine +TX, flupropazine hydrochloride +TX, norbormide +TX, fosacetim +TX, phosphorus +TX, pindone +TX, pyrinuron +TX, sciliroside +TX, sodium -fluoroacetate +TX, thallium sulfate +TX, warfarin +TX,2-(2-Butoxyethoxy)ethyl piperonylate + TX, 5-(1,3-benzodioxol-5-yl)-3-hexylcyclohex-2-enone + TX, farnesol + nerolidol + TX, berubutin + TX, MGK 264 + TX, piperonyl butoxide + TX, piprotal + TX, propyl isomer + TX, S421 + TX, sesamex + TX, sesamolin + TX, sulfoxide + TX, anthraquinone + TX, copper naphthenate + TX, copper oxychloride + TX, dicyclopentadiene + TX, thiram + TX, zinc naphthenate + TX, ziram + TX, imanin + TX, ribavirin + TX, chloroinconazide + TX, mercury(II) oxide + TX, thiophanate-methyl + T X, azaconazole + TX, bitertanol + TX, bromuconazole + TX, cyproconazole + TX, difenoconazole + TX, diniconazole + TX, epoxiconazole + TX, fenbuconazole + TX, fluquinconazole + TX, flusilazole + TX, flutriafol + TX, furametpyr + TX, hexaconazole + TX, imazalil + TX, imibenconazole + TX, ipconazole + TX, metconazole + TX, myclobutanil + TX, paclobutrazol +TX, pefurazoate +TX, penconazole +TX, prothioconazole +TX, pyrifenox +TX, prochloraz +TX, propiconazole +TX, pyrisoxazole +TX, -simeconazole +TX, tebuconazole +TX, tetraconazole +TX, triadimefon +TX, triadimenol +TX, triflumizole +TX, triticonazole +TX, ancymidol +TX, fenarimol +TX, nuarimol +TX, bupirimate +TX, dimethirimol +TX, ethirimo ol + TX, dodemorph + TX, fenpropizin + TX, fenpropimorph + TX, spiroxamine + TX, tridemorph + TX, cyprodinil + TX, mepanipyrim + TX, pyrimethanil + TX, fenpiclonil + TX, fludioxonil + TX, benalaxyl + TX, furalaxyl + TX, -metalaxyl- + TX, R-metalaxyl + TX, ofrace + TX, oxadixyl + TX, carbendazim + TX, debacarb + TX, fuberidazole- + TX, thiabendazole + TX,Chlozolinate +TX, Dichlozolin +TX, Mycrozolin +TX, Procymidone +TX, Vinclozolin +TX, Boscalid +TX, Carboxin +TX, Fenfuram +TX, Flutolanil +TX, Mepronil +TX, Oxycarboxin +TX, Penthiopyrad +TX, Thifluzamide +TX, Dodine +TX, Iminoctadine +TX, Azoxystrobin +TX, Dimoxystrobin +TX, Enestrobulin +TX, Phenaminestrobin +TX, Flufenoxystrobin +TX, Fluoxastrobin +TX, Kresoxim-methyl + TX, metominostrobin + TX, trifloxystrobin + TX, oryzastrobin + TX, picoxystrobin + TX, pyraclostrobin + TX, pyrametostrobin + TX, pyroxystrobin + TX, ferbam + TX, mancozeb + TX, maneb + ​​TX, metiram + TX, propineb + ​​TX, zineb + ​​TX, captafol + TX, captan + TX, fluoroimide + TX, folpet + TX, tolylfluanid + TX, Bordeaux mixture + TX, copper oxide + TX, mancopper + TX, copper oxine + TX, nitrothal-isopropyl + TX, Edifenphos + TX, Iprobenfos + TX, Fosdifen + TX, Turcofos-methyl + TX, Anilazine + TX, Benthiavalicarb + TX, Blasticidin-S + TX, Chloroneb + ​​TX, Chlorothalonil + TX, Cyflufenamid + TX, Cymoxanil + TX, Cyclobutrifluram + TX, Diclocymet + TX, Diclomedine + TX, Dicloran + TX, Diethofencarb + TX, Dimethomorph + TX, Flumorph + TX, Dithianon + TX, Ethaboxam + TX, Etridiazole + TX, Famoxadone + TX, Fen Amidon + TX, Fenoxanil + TX, Ferimzone + TX, Fluazinam + TX, Flumethylsulforim + TX, Fluopicolide + TX, Fluoxythioconazole + TX, Flusulfamide + TX, Fluxapyroxad + TX, Fenhexamid + TX, Fosetyl-aluminum- + TX, Hymexazole + TX, Iprovalicarb + TX, Cyazofamid + TX, Metasulfocarb + TX, Metrafenone + TX, Pencycuron + TX, Phthalide + TX, Polyoxin + TX, Propamocarb + TX,Pyribencarb + TX, proquinazide + TX, pyroquilon + TX, pyriophenone + TX, quinoxyfen + TX, quintozene + TX, tiadinil + TX, triazoxide + TX, tricyclazole + TX, triforine + TX, validamycin + TX, valifenalate + TX, zoxamide + TX, mandipropamide + TX, fluveneteram + TX, isopyrazam + TX, sedaxane + TX, benzovindiflupyr + TX, pydiflumetofen + TX, 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid (3',4',5'-trifluoro-biphenyl-2-yl)-amide + TX, isoflucipram + TX, isotianil + TX, dipimethitrone + TX, 6-ethyl-5,7-dioxo-pyrrolo[4,5][1,4]dithiino[ 1,2-c]isothiazole-3-carbonitrile + TX, 2-(difluoromethyl)-N-[3-ethyl-1,1-dimethyl-indan-4-yl]pyridine-3-carboxamide + TX, 4-(2,6-difluorophenyl)-6-methyl-5-phenyl-pyridazine-3-carbonitrile + TX, (R)-3-(difluoromethyl)-1-methyl-N-[1,1,3-trimethylindan-4-yl]pyrazole-4-carboxamide + TX, 4-(2-bromo-4-fluoro-phenyl)-N-(2-chloro-6-fluoro-phenyl)-2,5-dimethyl-pyrazol-3-amine + TX, 4-(2-bromo-4-fluorophenyl)-N-(2-chloro-6-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine + TX, Fluindapyr + TX, methoxystrobin (jiaxiangjunzhi) + TX, rubenmixianan + TX, diclobenthiazox + TX, mandestrobin + TX, 3-(4,4-difluoro-3,4-dihydro-3,3-dimethylisoquinolin-1-yl)quinolone + TX, 2-[2-fluoro-6-[(8-fluoro-2-methyl-3-quinolyl)oxy]phenyl]propan-2-ol + TX, oxathiapiprazole tetrazole + TX, tert-butyl N-[6-[[[(1-methyltetrazol-5-yl)-phenyl-methylene]amino]oxymethyl]-2-pyridyl]carbamate + TX, pyraziflumide + TX, inpirfluxam + TX, turolprocarb + TX, mefentrifluconazole + TX, ipfentrifluconazole + TX, 2-(difluoromethyl)-N-[(3R)-3-ethyl-1,1-dimethyl-indan-4-yl]pyridine-3-carboxamide + TX, N'-(2,5-dimethyl N'-[4-(4,5-dichlorothiazol-2-yl)oxy-2,5-dimethyl-phenyl]-N-ethyl-N-methyl-formamidine + TX, N'-[4-(4,5-dichlorothiazol-2-yl)oxy-2,5-dimethyl-phenyl]-N-ethyl-N-methyl-formamidine + TX, [2-[3-[2-[1-[2-[3,5-bis(difluoromethyl)pyrazol-1-yl]acetyl]-4-piperidyl]thiazol-4-yl]-4,5-dihydroisoxazol-5-yl]-3-chloro-phenyl]methanesulfonic acid + TX, Buta- 3-ynyl N-[6-[[(Z)-[(1-methyltetrazol-5-yl)-phenyl-methylene]amino]oxymethyl]-2-pyridyl]carbamate + TX, methyl N-[[5-[4-(2,4-dimethylphenyl)triazol-2-yl]-2-methyl-phenyl]methyl]carbamate + TX, 3-chloro-6-methyl-5-phenyl-4-(2,4,6-trifluorophenyl)pyridazine + TX, pyridaclomethyl + TX, 3-(difluoromethyl)-1-methyl-N-[1,1,3-Trimethylindan-4-yl]pyrazole-4-carboxamide + TX, 1-[2-[[1-(4-chlorophenyl)pyrazol-3-yl]oxymethyl]-3-methyl-phenyl]-4-methyl-tetrazol-5-one + TX, 1-methyl-4-[3-methyl-2-[[2-methyl-4-(3,4,5-trimethylpyrazol-1-yl)phenoxy]methyl]phenyl]tetrazol-5-one + TX, Nopirifen + TX, Ametoctrazine + TX, Amisulbrom + TX, Penflufen + TX, (Z,2E)-5-[1-(4-chlorophenyl)pyrazol-3-yl]oxy-2-methoxyimino-N,3-dimethyl-pent-3-enamide + TX, Florylpicoxamide + TX, Fenpicoxamide + TX, Methallylpicoxamide + TX, Tebufloquine + TX, Ipulfenoquine + TX, Quinofumelin + TX, Isofetamide + TX, ethyl 1-[[4-[[2-(trifluoromethyl)-1,3-dioxolan-2-yl]methoxy]phenyl]methyl]pyrazole-3-carboxylate (which may be prepared by the methods described in WO 2020 / 056090) + TX, ethyl 1-[[4-[(Z)-2-ethoxy-3,3,3-trifluoro-prop-1-enoxy]phenyl]methyl]pyrazole-3-carboxylate (which may be prepared by the methods described in WO 2020 / 056090) + TX, methyl N-[[4-[1-(4-cyclopropyl- 2,6-difluoro-phenyl)pyrazol-4-yl]-2-methyl-phenyl]methyl]carbamate (which can be prepared by the method described in WO 2020 / 097012) + TX, methyl N-[[4-[1-(2,6-difluoro-4-isopropyl-phenyl)pyrazol-4-yl]-2-methyl-phenyl]methyl]carbamate (which can be prepared by the method described in WO 2020 / 097012) + TX, 6-chloro-3-(3-cyclopropyl-2-fluoro-phenoxy)-N-[2-(2,4-dimethylphenyl)-2,2-di fluoro-ethyl]-5-methyl-pyridazine-4-carboxamide (which may be prepared by the methods described in WO 2020 / 109391) + TX, 6-chloro-N-[2-(2-chloro-4-methyl-phenyl)-2,2-difluoro-ethyl]-3-(3-cyclopropyl-2-fluoro-phenoxy)-5-methyl-pyridazine-4-carboxamide (which may be prepared by the methods described in WO 2020 / 109391) + TX, 6-chloro-3-(3-cyclopropyl-2-fluoro-phenoxy)-N-[2-(3,4-dimethylphenyl) N-[2-[2,4-dichloro-phenoxy]phenyl]-3-(difluoromethyl)-1-methyl-pyrazole-4-carboxamide + TX, N-[2-[2-chloro-4-(trifluoromethyl)phenoxy]phenyl]-3-(difluoromethyl)-1-methyl-pyrazole-4-carboxamide + TX, benzothiostrobin + TX, fenamacril + TX, 5-amino-1,3,4-Thiadiazole-2-thiol zinc salt (2:1) + TX, fluopyram + TX, flufenoxadiazam + TX, flutianil + TX, fluopimomide + TX, pyrapropoin + TX, picarbutrazox + TX, 2-(difluoromethyl)-N-(3-ethyl-1,1-dimethyl-indan-4-yl)pyridine-3-carboxamide + TX, 2-(difluoromethyl)-N-((3R)-1,1,3 -trimethylindan-4-yl)pyridine-3-carboxamide + TX, 4-[[6-[2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1,2,4-triazol-1-yl)propyl]-3-pyridyl]oxy]benzonitrile + TX, methyltetraprole + TX, 2-(difluoromethyl)-N-((3R)-1,1,3- ... Lysine-3-carboxamide + TX, α-(1,1-dimethylethyl)-α-[4'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]-5-pyrimidinemethanol + TX, fluoxapiproline + TX, enoxastrobin + TX, 4-[[6-[2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1,2,4-triazol-1-yl)propyl]- 3-pyridyl]oxy]benzonitrile + TX, 4-[[6-[2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(5-sulfanyl-1,2,4-triazol-1-yl)propyl]-3-pyridyl]oxy]benzonitrile + TX, 4-[[6-[2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(5-thioxo-4H-1,2,4-triazol-1-yl)propyl]-3-pyridyl]oxy]benzonitrile + TX, trinexapac + TX, cumoxystrobin + TX, zhongshengmycin + TX, copper thiodiazole + TX, zinc thiazole + TX, amethotractin + TX, iprodione + TX, seboxylamine + TX; N'-[5-bromo-2-methyl-6-[(1S)-1-methyl-2-propoxy]benzonitrile + TX, trinexapac + TX, cumoxystrobin + TX, zhongshengmycin + TX, copper thiodiazole + TX, zinc thiazole + TX, amethotractin + TX, iprodione + TX, seboxylamine + TX; N'-[5-bromo-2-methyl-6-[(1R)-1-methyl-2-propoxy-ethoxy]-3-pyridyl]-N-ethyl-N-methyl-formamidine + TX, N'-[5-bromo-2-methyl-6-(1-methyl-2-propoxy-ethoxy)-3-pyridyl]-N-ethyl-N-methyl-formamidine + TX, N'-[5-bromo-2-methyl-6-(1-methyl-2-propoxy-ethoxy)-3-pyridyl]-N-ethyl-N-methyl-formamidine + TX, N'-[5-chloro N'-[5-bromo-2-methyl-6-(1-methyl-2-propoxy-ethoxy)-3-pyridyl]-N-ethyl-N-methyl-formamidine + TX, N'-[5-bromo-2-methyl-6-(1-methyl-2-propoxy-ethoxy)-3-pyridyl]-N-isopropyl-N-methyl-formamidine + TX (these compounds can be prepared by the method described in WO 2015 / 155075); N'-[5-bromo-2-methyl- 6-(2-propoxypropoxy)-3-pyridyl]-N-ethyl-N-methyl-formamidine + TX (this compound can be prepared by the method described in IPCOM000249876D); N-isopropyl-N'-[5-methoxy-2-methyl-4-(2,2,2-trifluoro-1-hydroxy-1-phenyl-ethyl)phenyl]-N-methyl-formamidine + TX, N'-[4-(1-cyclopropyl-2,2,2-trifluoro-1-hydroxy-ethyl)-5-methoxy-2-methyl-phenyl]-N-isopropyl-N-methyl-formamidine + TX (these compounds can be prepared by the method described in WO 2018 / 228896); N-ethyl-N'-[5-methoxy-2-methyl-4-[(2-trifluoromethyl)oxetan-2-yl]phenyl]-N-methyl-formamidine + TX, N-ethyl-N'-[5-methoxy-2-methyl-4-[(2-trifluoromethyl)oxetan-2-yl]phenyl]-N-methyl-formamidine + TX N-[(1R)-1-benzyl-3-chloro-1-methyl-but-3-enyl]-8-fluoro-quinoline-3-carboxamide + TX, N-[(1S)-1-benzyl-3-chloro-1-methyl-but-3-enyl]-8-fluoro-quinoline-3-carboxamide + TX, N-[(1R ...S)-1-benzyl-3-chloro-1-methyl-but-3-enyl]-8-fluoro-quinoline-3-carboxamide + TX, N-[(1S)-1-benzyl-3,3,3-trifluoro-1-methyl-propyl]-8-fluoro-quinoline-3-carboxamide + TX, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-7,8-difluoro-quinoline-3-carboxamide + TX, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-7,8-difluoro-quinoline 8-Fluoro-N-[(1R)-1-[(3-fluorophenyl)methyl]-1,3-dimethyl-butyl]quinoline-3-carboxamide + TX, 8-Fluoro-N-[(1S)-1-[(3-fluorophenyl)methyl]-1,3-dimethyl-butyl]quinoline-3-carboxamide + TX, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide + TX, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide + TX, N-((1R)-1-benzyl-3-chloro-1-methyl-but-3-enyl)-8-fluoro-quinoline-3-carboxamide + TX, N-((1S)-1-benzyl-3-chloro-1-methyl-but-3-enyl)-8-fluoro-quinoline-3-carboxamide + TX (these compounds can be prepared by the method described in WO 2017 / 153380); 1-(6,7-dimethylpyrazolo[1,5-a]pyridin-3-yl)-4,4,5-trimethylpyrazole-3-yl Fluoro-3,3-dimethyl-isoquinoline + TX, 1-(6,7-dimethylpyrazolo[1,5-a]pyridin-3-yl)-4,4,6-trifluoro-3,3-dimethyl-isoquinoline + TX, 4,4-difluoro-3,3-dimethyl-1-(6-methylpyrazolo[1,5-a]pyridin-3-yl)isoquinoline + TX, 4,4-difluoro-3,3-dimethyl-1-(7-methylpyrazolo[1,5-a]pyridin-3-yl)isoquinoline + TX, 1-(6-chloro-7-methyl-pyrazolo[1,5-a]pyridin-3-yl)-4 ,4-difluoro-3,3-dimethyl-isoquinoline + TX (these compounds can be prepared by the method described in WO 2017 / 025510); 1-(4,5-dimethylbenzimidazol-1-yl)-4,4,5-trifluoro-3,3-dimethyl-isoquinoline + TX, 1-(4,5-dimethylbenzimidazol-1-yl)-4,4-difluoro-3,3-dimethyl-isoquinoline + TX, 6-chloro-4,4-difluoro-3,3-dimethyl-1-(4-methylbenzimidazol-1-yl)isoquinoline + TX, 4 , 4-difluoro-1-(5-fluoro-4-methyl-benzimidazol-1-yl)-3,3-dimethyl-isoquinoline + TX, 3-(4,4-difluoro-3,3-dimethyl-1-isoquinolyl)-7,8-dihydro-6H-cyclopenta[e]benzimidazole + TX (these compounds can be prepared by the method described in WO 2016 / 156085); N-methoxy-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]cyclopropanecarboxamide + TX, N,2-Dimethoxy-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide + TX, N-ethyl-2-methyl-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide + TX, 1-methoxy-3-methyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea + TX, 1,3-dimethoxy-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea + TX, 3-ethyl-1-methoxy-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea + TX, N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide + TX, 4,4-dimethyl-2-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]isoxazolidin-3-one + TX, 5,5-dimethyl-2-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]isoxazolidin-3-one + TX, ethyl 1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]pyrazole-4-carboxylate + TX, N,N-dimethyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]-1,2,4-triazol-3-amine + TX. The compounds in this paragraph can be prepared by the methods described in WO 2017 / 055473, WO 2017 / 055469, WO 2017 / 093348, and WO 2017 / 118689; 2-[6-(4-chlorophenoxy)-2-(trifluoromethyl)-3-pyridyl]-1-(1,2,4-triazol-1-yl)propan-2-ol + TX (this compound can be prepared by the method described in WO 2017 / 029179); 2-[6-(4-bromophenoxy)-2-(trifluoromethyl)-3-pyridyl]-1-(1,2,4-triazol-1-yl)propan-2-ol + TX (this compound can be prepared by the method described in WO 2017 / 029179). Pan-2-ol + TX (this compound can be prepared by the method described in WO 2017 / 029179); 3-[2-(1-chlorocyclopropyl)-3-(2-fluorophenyl)-2-hydroxypropyl]imidazole-4-carbonitrile + TX (this compound can be prepared by the method described in WO 2016 / 156290); 3-[2-(1-chlorocyclopropyl)-3-(3-chloro-2-fluorophenyl)-2-hydroxypropyl]imidazole-4-carbonitrile + TX (this compound can be prepared by the method described in WO 2016 / 156290);(4-phenoxyphenyl)methyl 2-amino-6-methyl-pyridine-3-carboxylate + TX (this compound can be prepared by the method described in WO 2014 / 006945); 2,6-dimethyl-1H,5H-[1,4]dithiino[2,3-c:5,6-c']dipyrrole-1,3,5,7(2H,6H)-tetrone + TX (this compound can be prepared by the method described in WO 2011 / 138281); N-methyl-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzene Carbothioamide + TX; N-methyl-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide + TX; (Z,2E)-5-[1-(2,4-dichlorophenyl)pyrazol-3-yl]oxy-2-methoxyimino-N,3-dimethyl-pent-3-enamide + TX (this compound can be prepared by the method described in WO 2018 / 153707); N'-(2-chloro-5-methyl-4-phenoxy-phenyl)-N-ethyl-N-methyl-formamidine + TX; N'-[2-chloro -4-(2-fluorophenoxy)-5-methyl-phenyl]-N-ethyl-N-methyl-formamidine + TX (this compound can be prepared by the method described in WO 2016 / 202742); 2-(difluoromethyl)-N-[(3S)-3-ethyl-1,1-dimethyl-indan-4-yl]pyridine-3-carboxamide + TX (this compound can be prepared by the method described in WO 2014 / 095675); (5-methyl-2-pyridyl)-[4-[5-(trifluoromethyl)-1,2,4-oxadiazo (3-methylisoxazol-5-yl)-[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methanone + TX, (3-methylisoxazol-5-yl)-[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methanone + TX (these compounds can be prepared by the methods described in WO 2017 / 220485); 2-oxo-N-propyl-2-[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]acetamide + TX (this compound can be prepared by the methods described in WO 2018 / 065414);Ethyl 1-[[5-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]-2-thienyl]methyl]pyrazole-4-carboxylate + TX (this compound can be prepared by the method described in WO 2018 / 158365); 2,2-difluoro-N-methyl-2-[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]acetamide + TX, N-[(E)-methoxyiminomethyl]-4-[5-(trifluoromethyl)-1,2 ,4-oxadiazol-3-yl]benzamide + TX, N-[(Z)-methoxyiminomethyl]-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide + TX, N-[N-methoxy-C-methyl-carbonimidoyl]-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide + TX (these compounds can be prepared by the methods described in WO 2018 / 202428); Microorganisms including: Acinetobacter lwoffii + TX, Acremonium alternatum + TX, Acremonium cephalosporium + TX, Acremonium diospyri + TX, Acremonium obclavatum + TX, Adoxophyes orana granulovirus (AdoxGV) (Capex®) + TX, Agrobacterium radiobacter strain K84 (Galltrol-A®) + TX, Alternaria alternata + TX, Alternaria cassiae + TX, cassia) + TX, Alternaria destruens (Smolder®) + TX, Ampelomyces quisqualis (AQ10®) + TX, Aspergillus flavus AF36 (AF36®) + TX, Aspergillus flavus NRRL 21882 (Aflaguard®) + TX, Aspergillus spp.) + TX, Aureobasidium pullulans + TX, Azospirillum + TX, (MicroAZ® + TX, TAZO B®) + TX, Azotobacter + TX, Azotobacter chroocuccum (Azotomeal®) + TX, Azotobacter cyst (Bionatural Blooming Blossoms®) + TX, Bacillus amyloliquefaciens + TX, Bacillus cereus + TX, Bacillus chitinosporus strain CM-1 + TX, Bacillus chitinosporus strain AQ746+TX, Bacillus licheniformis strain HB-2 (Biostart™ Rhizoboost®)+TX, Bacillus licheniformis strain 3086 (EcoGuard®+TX, Green Releaf®)+TX, Bacillus circulans+TX, Bacillus firmus (BioSafe®+TX, BioNem-WP®+TX, VOTiVO®)+TX, Bacillus firmus strain I-1582+TX, Bacillus macerans+TX, Bacillus marismortui (Bacillus marismortui + TX, Bacillus megaterium + TX, Bacillus mycoides strain AQ726 + TX, Bacillus papillae (Milky Spore Powder®) + TX, Bacillus pumilus spp.) +TX, Bacillus pumilus strain GB34 (Yield Shield®) +TX, Bacillus pumilus strain AQ717 +TX, Bacillus pumilus strain QST 2808 (Sonata® +TX, Ballad Plus®) +TX, Bacillus spahericus (VectoLex®) +TX, Bacillus spp. +TX, Bacillus spp. strain AQ175 +TX, Bacillus spp. strain AQ177 +TX, Bacillus spp. strain AQ178 +TX, Bacillus Bacillus subtilis strain QST 713 (CEASE(R)+TX, Serenade(R)+TX, Rhapsody(R))+TX, Bacillus subtilis strain QST 714(JAZZ(R))+TX, Bacillus subtilis strain AQ153+TX, Bacillus subtilis strain Bacillus subtilis strain AQ743+TX, Bacillus subtilis strain QST3002+TX, Bacillus subtilis strain QST3004+TX, Bacillus subtilis var. amyloliquefaciens.amyloliquefaciens strain FZB24 (Taegro® +TX, Rhizopro®) +TX, Bacillus thuringiensis Cry 2Ae +TX, Bacillus thuringiensis Cry1Ab +TX, Bacillus thuringiensis aizawai GC 91 (Agree®) +TX, Bacillus thuringiensis israelensis (BMP123® +TX, Aquabac® +TX, VectoBac®) +TX, Bacillus thuringiensis kurstaki Bacillus thuringiensis kurstaki (Javelin® + TX, Deliver® + TX, CryMax® + TX, Bondide® + TX, Scutella WP® + TX, Turilav WP® + TX, Astuto® + TX, Dipel WP® + TX, Biobit® + TX, Foray®) + TX, Bacillus thuringiensis kurstaki BMP 123 (Baritone®) + TX, Bacillus thuringiensis kurstaki HD-1 (Bioprotec-CAF / 3P®) + TX, Bacillus thuringiensis strain BD#32 ... thuringiensis strain AQ52+TX, Bacillus thuringiensis var. aizawai (XenTari®+TX, DiPel®)+TX, bacterial spp.) (GROWMEND® +TX, GROWSWEET® +TX, Shootup®) +TX, Clavipacter michiganensis bacteriophage (AgriPhage®) +TX, Bakflor® +TX, Beauveria bassiana (Beaugenic® +TX, Brocaril WP®) +TX, Beauveria bassiana GHA (Mycotrol ES® +TX, Mycotrol O® +TX, BotaniGuard®) +TX, Beauveria brongniartii (Engerlingspilz® +TX, Schweizer Beauveria® +TX, Melocont®) +TX, Beauveria spp. spp.) + TX, Botrytis cineria + TX, Bradyrhizobium japonicum (TerraMax®) + TX, Brevibacillus brevis + TX, Bacillus thuringiensis tenebrionis (Novodor®) + TX, BtBooster + TX, Burkholderia cepacia (Deny® + TX, Intercept® + TX, Blue Circle®) + TX, Burkholderia gladii + TX, Burkholderia gladioli + TX, Burkholderia spp.) + TX, Canadian thistle fungus (CBH Canadian Bioherbicide®) + TX, Candida butyri + TX, Candida famata + TX, Candida fructus + TX, Candida glabrata + TX, Candida guilliermondii + TX, Candida melibiosica + TX, Candida oleophila strain O + TX, Candida parapsilosis + TX, Candida pelliculosa + TX, Candida pulcherrima pulcherrima + TX, Candida reukaufii + TX, Candida saitoana (Bio-Coat® + TX, Biocure®) + TX, Candida sake + TX, Candida spp. + TX, Candida tenius + TX, Cedecea dravisae + TX, Cellulomonas flavigena + TX, Chaetomium cochliodes (Nova-Cide®) + TX, Chaetomium globosum (Nova-Cide®) + TX, Chromobacterium subtsugae) strain PRAA4-1T (Grandevo®) + TX,. Cladosporium cladosporioides + TX, Cladosporium oxysporum + TX, Cladosporium chlorocephalum + TX, Cladosporium spp. + TX, Cladosporium tenuissimum + TX, Clonostachys rosea (EndoFine®) + TX, Colletotrichum acutatum + TX, Coniothyrium minitans (Cotans WG®) + TX, Coniothyrium spp.) + TX, Cryptococcus albidus (YIELDPLUS®) + TX, Cryptococcus humicola + TX, Cryptococcus infirmo-miniatus + TX, Cryptococcus laurentii + TX, Cryptophlebia leucotreta granulovirus (Cryptex®) + TX, Cupriavidus campinensis + TX, Codling moth granulovirus (Cydia pomonella granulovirus) (CYD-X®) + TX, Codling moth granulovirus (Cydia pomonella granulovirus) (Madex® + TX, Madex Plus® + TX, Madex Max / Carpovirusine®) + TX, Cylindrobasidium laeve (Stumpout®) + TX, Cylindrocladium + TX, Debaryomyces hansenii + TX, Drechslera hawaiinensis + TX, Enterobacter cloacae + TX, Enterobacteriaceae + TX, Entomophtora virulenta (Vektor®) + TX, Epicoccum nigrum + TX, Epicoccum perparascens purpurascens) + TX, Epicoccum spp.) + TX, Filobasidium floriforme + TX, Fusarium acuminatum + TX, Fusarium chlamydosporum + TX, Fusarium oxysporum (Fusaclean® / Biofox C®) + TX, Fusarium proliferatum + TX, Fusarium spp. + TX, Galactomyces geotrichum + TX, Gliocladium catenulatum (Primastop® + TX, Prestop®) + TX, Gliocladium roseum roseum + TX, Gliocladium spp. (SoilGard®) + TX, Gliocladium virens (Soilgard®) + TX, Granulovirus (Granupom®) + TX, Halobacillus halophilus + TX, Halobacillus litoralis + TX, Halobacillus trueperi + TX, Halomonas spp.) + TX, Halomonas subglaciescola + TX, Halovibrio variabilis + TX, Hanseniaspora uvarum + TX, Helicoverpa armigera nucleopolyhedrovirus (Helicovex®) + TX, Helicoverpa zea nuclear polyhedrosis virus (Gemstar®) + TX, isoflavone-formononetin (Myconate®) + TX, Kloeckera apiculata + TX, Kloeckera spp.) + TX, Lagenidium giganteum (Laginex®) + TX, Lecanicillium longisporum (Vertiblast®) + TX, Lecanicillium muscarium (Vertikil®) + TX, Lymantria Dispar nucleopolyhedrosis virus (Disparvirus®) + TX, Marinococcus halophilus + TX, Meira geulakonigii + TX, Metarhizium anisopliae (Met52®) + TX, Metarhizium anisopliae (Destruxin®) + TX, WP®) + TX, Metschnikowia fruticola (Shemer®) + TX, Metschnikowia pulcherrima + TX, Microdochium dimerum (Antibot®) + TX, Micromonospora coerulea + TX, Microsphaeropsis ochracea + TX, Muscodor albus 620 (Muscudor®) + TX, Muscodor roseus strain A3-5 + TX, Mycorrhizae spp.) (AMykor® +TX, Root Maximizer®) +TX, Myrothecium verrucaria strain AARC-0255 (DiTera®) +TX, BROS PLUS® +TX, Ophiostoma piliferum strain D97 (Sylvanex®) +TX, Paecilomyces farinosus +TX, Paecilomyces fumosoroseus (PFR-97® +TX, PreFeRal®) +TX, Paecilomyces linacinus (Biostat WP®) +TX, Paecilomyces lilacinus lilacinus strain 251 (MeloCon WG®) + TX, Paenibacillus polymyxa + TX, Pantoea agglomerans (BlightBan C9-1®) + TX, Pantoea spp. + TX, Pasteuria spp. (Econem®) + TX, Pasteuria nishizawae + TX, Penicillium aurantiogriseum + TX, Penicillium billai (Jumpstart® + TX, TagTeam®) + TX, Penicillium brevicompactum brevicompactum + TX, Penicillium frequentans + TX, Penicillium griseofulvum + TX, Penicillium purpurogenum + TX, Penicillium spp.) + TX, Penicillium viridicatum + TX, Phlebiopsis gigantean (Rotstop®) + TX, Phosphate-dissolving bacteria (Phosphomeal®) + TX, Phytophthora cryptogea + TX, Phytophthora palmivora (Devine®) + TX, Pichia anomala + TX, Pichia guilermondii + TX, Pichia membranaefaciens + TX, Pichia onychis + TX, Pichia stipites + TX, Pseudomonas aeruginosa aeruginosa + TX, Pseudomonas aureofaciens (Spot-Less Biofungicide®) + TX, Pseudomonas cepacia + TX, Pseudomonas chlororaphis (AtEze®) + TX, Pseudomonas corrugate + TX, Pseudomonas fluorescens strain A506 (BlightBan A506®) + TX, Pseudomonas putida + TX, Pseudomonas reactans + TX, Pseudomonas spp. + TX, Pseudomonas syringae (Bio-Save®) + TX, Pseudomonas viridiflava + TX, Pseudomonas fluorescens fluorescens (Zequanox®) + TX, Pseudozyma flocculosa strain PF-A22 UL (Sporodex L®) + TX, Puccinia canaliculata + TX, Puccinia thlaspeos (Wood Warrior®) + TX, Pythium paroecandrum + TX, Pythium oligandrum (Polygandron® + TX, Polyversum®) + TX, Pythium periplocum + TX, Rhanella aquatilis + TX, Rhanella spp.) + TX, Rhizobia (Dormal® + TX, Vault®) + TX, Rhizoctonia + TX, Rhodococcus globerulus strain AQ719 + TX, Rhodosporidium diobovatum + TX, Rhodosporidium toruloides + TX, Rhodotorula spp. + TX, Rhodotorula glutinis + TX, Rhodotorula graminis + TX, Rhodotorula mucilagnosa + TX, Rhodotorula rubra rubra + TX, Saccharomyces cerevisiae + TX, Salinococcus roseus + TX, Sclerotinia minor + TX, Sclerotinia minor (SARRITOR®) + TX, Scytalidium spp. + TX, Scytalidium uredinicola + TX, Spodoptera exigua nuclear polyhedrosis virus (Spod-X® + TX, Spexit®) + TX, Serratia marcescens + TX, Serratia plymuthica + TX, Serratia spp.) + TX, Sordaria fimicola + TX, Spodoptera littoralis nucleopolyhedrovirus (Littovir®) + TX, Sporobolomyces roseus + TX, Stenotrophomonas maltophilia + TX, Streptomyces ahygroscopicus + TX, Streptomyces albaduncus + TX, Streptomyces exfoliates + TX, Streptomyces galbus + TX, Streptomyces griseoplanus griseoplanus + TX, Streptomyces griseoviridis (Mycostop®) + TX, Streptomyces lydicus (Actinovate®) + TX, Streptomyces lydicus WYEC-108 (ActinoGrow®) + TX, Streptomyces violaceus + TX, Tilletiopsis minor + TX, Tilletiopsis spp.) + TX, Trichoderma asperellum (T34 Biocontrol®) + TX, Trichoderma gamsii (Tenet®) + TX, Trichoderma atroviride (Plantmate®) + TX, Trichoderma hamatum TH 382 + TX, Trichoderma harzianum rifai (Mycostar®) + TX, Trichoderma harzianum T-22 (Trianum-P® + TX, PlantShield HC® + TX, RootShield® + TX, Trianum-G®) + TX, Trichoderma harzianum harzianum) T-39 (Trichodex®) + TX, Trichoderma inhamatum + TX, Trichoderma koningii + TX, Trichoderma spp.) LC 52 (Sentinel®) + TX, Trichoderma lignorum + TX, Trichoderma longibrachiatum + TX, Trichoderma polysporum (Binab T®) + TX, Trichoderma taxi + TX, Trichoderma virens + TX, Trichoderma virens (formerly Gliocladium virens GL-21) (SoilGuard®) + TX, Trichoderma viride + TX, Trichoderma viride strain ICC 080 (Remedier®) + TX, Trichosporon pullulans + TX, Trichosporon spp. + TX, Trichothecium spp.) + TX, Trichothecium roseum + TX, Typhula phacorrhiza strain 94670 + TX, Typhula phacorrhiza strain 94671 + TX, Ulocladium atrum + TX, Ulocladium oudemansii (Botry-Zen®) + TX, Ustilago maydis + TX, various bacteria and supplemental micronutrients (Natural II®) + TX, various fungi (Millennium Microbes®) + TX, Verticillium chlamydosporium + TX, Verticillium lecanii lecanii (Mycotal® + TX, Vertalec®) + TX, Vip3Aa20 (VIPtera®) + TX, Virgibaclillus marismortui + TX, Xanthomonas campestris pv. Poae (Camperico®) + TX, Xenorhabdus bovienii + TX, Xenorhabdus nematophilus; Plant extracts including: pine oil (Retenol®) +TX, azadirachtin (Plasma), Neem Oil® +TX, AzaGuard® +TX, MeemAzal® +TX, Molt-X® +TX, botanical insect growth regulators (Neemazad® +TX, Neemix®) +TX, rapeseed oil (Lilly Miller Vegol®) +TX, American ant's weed (Chenopodium ambrosioides near ambrosioides) (Requiem®) +TX, Chrysanthemum extract (Crisant®) +TX, neem oil extract (Trilogy®) +TX, Labiatae essential oil (Botania®) +TX, clove, rosemary, peppermint, and thyme oil extracts (Garden insect killer®) + TX, glycine betaine (Greenstim®) + TX, garlic + TX, lemongrass oil (GreenMatch®) + TX, neem oil + TX, catnip (Nepeta cataria) (catnip oil) + TX, catnip (Nepeta catarina) + TX, nicotine + TX, oregano oil (MossBuster®) + TX, sesame (Pedaliaceae) oil (Nematon®) + TX, pyrethrum + TX, soapberry (Quillaja saponaria) (NemaQ®) + TX, giant knotweed (Reynoutria sachalinensis) (Regalia® + TX, Sakalia®) + TX, rotenone (Eco Roten®) + TX, Rutaceae extract (Soleo®) + TX, soybean oil (Ortho ecosense®) +TX, tea tree oil (Timorex Gold®) +TX, thyme oil +TX, AGNIQUE® MMF +TX, BugOil® +TX, a mixture of rosemary, sesame, peppermint, thyme and cinnamon extracts (EF300®) + TX, a mixture of clove rosemary and peppermint extracts (EF 400®) + TX, a mixture of clove peppermint garlic oil and mint (Soil Shot®) + TX, kaolin (Screen®) + TX, storage glucan from brown algae (Laminarin®); Pheromones, including: blackheaded fireworm pheromone (3M Sprayable Blackheaded Fireworm Pheromone®) + TX, codling moth pheromone (Paramount dispenser-(CM) / Isomate C-Plus®) + TX, grape berry moth pheromone (3M MEC-GBM Sprayable Pheromone®) + TX, leafroller pheromone (3M MEC-LR Sprayable Pheromone®) + TX, muscamone (Snip7 Fly Bait® + TX, Starbar Premium Fly Bait®) + TX, oriental fruit moth pheromone (3M oriental fruit moth sprayable pheromone®) + TX, peachtree Borer pheromone (Isomate-P®) + TX, Tomato Pinworm pheromone (3M Sprayable pheromone®) + TX, Entostat powder (palm tree extract) (Exosex CM®) + TX, (E+TX,Z+TX,Z)-3+TX,8+TX,11-tetradecatrienyl acetate + TX, (Z+TX,Z+TX,E)-7+TX,11+TX,13-hexadecatrienal + TX, (E+TX,Z)-7+TX,9-dodecadien-1-yl acetate + TX, 2-methyl-1-butanol + TX, calcium acetate + TX, Scenturion® + TX, Biolure® + TX, Check-Mate® + TX, Lavandulyl senecioate; Macrobials, including: Aphelinus abdominalis + TX, Aphidius ervi (Aphelinus-System®) + TX, Acerophagus papaya + TX, Adalia bipunctata (Adalia-System®) + TX, Adalia bipunctata (Adaline®) + TX, Adalia bipunctata (Aphidalia®) + TX, Ageniaspis citricola + TX, Ageniaspis fuscicollis + TX, Amblyseius andersonii andersoni (Anderline® + TX, Andersoni-System®) + TX, Amblyseius californicus (Amblyline® + TX, Spical®) + TX, Amblyseius cucumeris (Thripex® + TX, Bugline cucumeris®) + TX, Amblyseius fallacis (Fallacis®) + TX, Amblyseius swirskii (Bugline swirskii® + TX, Swirskii-Mite®) + TX, Amblyseius womersleyi (WomerMite®) + TX, Amitus hesperidum hesperidum) + TX, Anagrus atomus + TX, Anagyrus fusciventris + TX, Anagyrus kamali + TX, Anagyrusloecki + TX, Anagyrus pseudococci (Citripar®) + TX, Anicetus benefices + TX, Anisopteromalus calandrae + TX, Anthocoris nemoralis (Anthocoris-System®) + TX, Aphelinus abdominalis (Apheline® + TX, Aphiline®) + TX, Aphelinus asychis + TX, Aphidius colemani (Aphipar®) + TX, Aphidius ervi (Ervipar®) + TX, Aphidius gifuensis gifuensis + TX, Aphidius matricariae (Aphipar-M®) + TX, Aphidoletes aphidimyza (Aphidend®) + TX, Aphidoletes aphidimyza (Aphidoline®) + TX, Aphytis lingnanensis + TX, Aphytis melinus + TX, Aprostocetus hagenowii + TX, Atheta coriaria (Staphyline®) + TX, Bombus spp. + TX, Bombus terrestris terrestris) (Natupol Beehive®) + TX, European bumblebee (Bombus terrestris) (Beeline® + TX, Tripol®) + TX, Cephalonomia stephanoderisstephanoderis + TX, Chilocorus nigritus + TX, Chrysoperla carnea (Chrysoline®) + TX, Chrysoperla carnea (Chrysopa®) + TX, Chrysoperla rufilabris + TX, Cirrospilus ingenuus + TX, Cirrospilus quadristriatus + TX, Citrostichus phyllocnistoides + TX, Closterocerus chamaeleon + TX, Closterocerus spp.) + TX, Coccidoxenoides perminutus (Planopar®) + TX, Coccophagus cowperi + TX, Coccophagus lycimnia + TX, Cotesia flavipes + TX, Cotesia plutellae + TX, Cryptolaemus montrouzieri (Cryptobug® + TX, Cryptoline®) + TX, Cybocephalus nipponicus + TX, Dacnusa sibirica + TX, Dacnusa sibirica (Minusa®) + TX, Diglyphus isaea (Diminex®) + TX, Delphastus catalinae (Delphastus®) + TX, Delphastus pusillus + TX, Diachasmimorpha clausiikrausii + TX, Diachasmimorpha longicaudata + TX, Diaparsis jucunda + TX, Diaphorencyrtus aligarhensis + TX, Diglyphus isaea + TX, Diglyphus isaea (Miglyphus® + TX, Digline®) + TX, Dacnusa sibirica (DacDigline® + TX, Minex®) + TX, Diversinervus spp. + TX, Encarsia citrina + TX, Encarsia formosa (Encarsia max® + TX, Encarline® + TX, En-Strip® + TX, Eretmocerus eremicus (Enermix®) + TX, Encarsia guadeloupae + TX, Encarsia haitiensis + TX, Episyrphus balteatus (Syrphidend®) + TX, Eretmoceris siphonini + TX, Eretmocerus californicus + TX, Eretmocerus eremicus (Ercal® + TX, Eretline e®) + TX, Eretmocerus eremicus (Bemimix®) + TX, Eretmocerus hayati + TX, Eretmocerus mundus (Bemipar® + TX, Eretline m®) + TX, Eretmocerus siphoninisiphonini + TX, Exochomus quadripustulatus + TX, Feltiella acarisuga (Spidend®) + TX, Feltiella acarisuga (Feltiline®) + TX, Fopius arisanus + TX, Fopius ceratitivorus + TX, Formononetin (Wirless Beehome®) + TX, Franklinothrips vespiformis (Vespop®) + TX, Galendromus occidentalis + TX, Goniozus legneri + TX, Habrobracon hebetor + TX, Harmonia axyridis (HarmoBeetle®) + TX, Heterorhabditis spp. (Lawn Patrol®) + TX, Heterorhabditis bacteriophora (NemaShield HB® + TX, Nemaseek® + TX, Terranem-Nam® + TX, Terranem® + TX, Larvanem® + TX, B-Green® + TX, NemAttack® + TX, Nematop®) + TX, Heterorhabditis megidis (Nemasys H® + TX, BioNem H® + TX, Exhibitline hm® + TX, Larvanem-M® + TX, Hippodamia convergens + TX, Hypoaspis aculeiferaculeifer) (Aculeifer-System® + TX, Entomite-A®) + TX, Hypoaspis miles (Hypoline m® + TX, Entomite-M®) + TX, Lbalia leucospoides + TX, Lecanoideus floccissimus + TX, Lemophagus errabundus + TX, Leptomastidea abnormis + TX, Leptomastix dactylopii (Leptopar®) + TX, Leptomastix epona + TX, Lindorus lophanthae + TX, Lipolexis oregmae + TX, Lucilia caesar (Natufly®) + TX, Lysiphlebus testacapes testaceipes + TX, Macrolophus caliginosus (Mirical-N® + TX, Macroline c® + TX, Mirical®) + TX, Mesoseiulus longipes + TX, Metaphycus flavus + TX, Metaphycus lounsburyi + TX, Micromus angulatus (Milacewing®) + TX, Microterys flavus + TX, Muscidifurax raptorellus and Spalangia cameroni (Biopar®) + TX, Neodryinus typhlocybae + TX, Neoseiulus californicus + TX, Neoseiulus cucumeris (THRYPEX®) + TX, Neoseiulus fallacis + TX, Nesideocoris tenuistenuis (NesidioBug® + TX, Nesibug®) + TX, Ophyra aenescens (Biofly®) + TX, Orius insidiosus (Thripor-I® + TX, Oriline i®) + TX, Orius laevigatus (Thripor-L® + TX, Oriline l®) + TX, Orius majusculus (Oriline m®) + TX, Orius strigicollis (Thripor-S®) + TX, Pauesia juniperorum (Pauesia juniperorum) + TX, Pediobius foveolatus + TX, Phasmarhabditis hermaphrodita (Nemaslug®) + TX, Phymastichus coffea + TX, Phytoseiulus macropilus + TX, Phytoseiulus persimilis (Spidex® + TX, Phytoline p®) + TX, Podisus maculiventris (Podisus®) + TX, Pseudacteon curvatus + TX, Pseudacteon obtusus + TX, Pseudacteon tricuspis + TX, Pseudaphycus maculipennis + TX, Pseudleptomastix mexicana + TX, Psyllaephagus pilosus + TX, Psyttaliaconcolor (complex) + TX, Quadrastichus spp. + TX, Rhyzobius lophanthae + TX, Rodolia cardinalis + TX, Rumina decollate + TX, Semielacher petiolatus + TX, Sitobion avenae (Ervibank®) + TX, Steinernema carpocapsae (Nematac C® + TX, Millennium® + TX, BioNem C® + TX, NemAttack® + TX, Nemastar® + TX, Capsanem®) + TX, Steinernema feltiae feltiae) (NemaShield® +TX, Nemasys F® +TX, BioNem F® +TX, Steinernema-System® +TX, NemAttack® +TX, Nemaplus® +TX, Exhibitline sf® +TX, Scia-rid® +TX, Entonem®) +TX, Steinernema kraussei (Nemasys L® +TX, BioNem L® +TX, Exhibitline srb®) +TX, Steinernema riobrave (BioVector® +TX, BioVektor®) +TX, Steinernema scapterisci (Nematac S(R)) + TX, Steinernema spp. + TX, Steinernema spp. (Guardian Nematodes(R)) + TX, Stethorus punctilumpunctillum (Stethorus®) + TX, Tamarixia radiate + TX, Tetrastichus setifer + TX, Thripobius semiluteus + TX, Torymus sinensis + TX, Trichogramma brassicae (Tricholine b®) + TX, Trichogramma brassicae (Tricho-Strip®) + TX, Trichogramma evanescens + TX, Trichogramma minutum + TX, Trichogramma ostriniae + TX, Trichogramma pratoneri platneri + TX, Trichogramma pretiosum + TX, Xanthopimpla stemmator; Other biological products include: abscisic acid +TX, bioSea® +TX, Chondrostereum purpureum (Chontrol Paste®) +TX, Colletotrichum gloeosporioides (Collego®) +TX, copper octanoate (Cueva®) +TX, Delta Trap (Trapline d®) +TX, Erwinia amylovora (Harpin) (ProAct® +TX, Ni-HIBIT Gold CST®) +TX, fatty acids derived from natural by-products of extra virgin olive oil (FLIPPER®) +TX, ferric phosphate (Ferri-phosphate) (Ferramol®) +TX, Funnel Trap (Trapline y®) +TX, Gallex® +TX, Grower's Secret® +TX, Homo-brassonolide +TX, Iron phosphate (Lilly Miller Worry Free Ferramol Slug & Snail Bait®) +TX, MCP hail trap (Trapline f®) +TX, Microctonus hyperodae +TX, Mycoleptodiscus terrestris (Des-X®) +TX, BioGain® +TX, Aminomite® +TX, Zenox® +TX, pheromone trap (Thripline ams®) + TX, potassium bicarbonate (MilStop®) + TX, potassium salts of fatty acids (Sanova®) + TX, potassium silicate solution (Sil-Matrix®) + TX, potassium iodide + potassium thiocyanate (Enzicur®) + TX, SuffOil-X® + TX, spider venom + TX, Nosema locustae (Semaspore Organic Grasshopper)Control®) + TX, sticky traps (Trapline YF® + TX, Rebell Amarillo®) + TX and traps (Takitrapline y+b®) + TX; (1) an antibacterial agent selected from the group consisting of: (1.1) Examples are bacteria such as: Bacillus mojavensis strain R3B (accession number NCAIM(P)B001389) from Certis USA LLC (a subsidiary of Mitsui & Co., Ltd.) (WO 2013 / 034938) + TX; Bacillus pumilus, in particular the strain BU F-33 with NRRL accession number 50185 (available as part of the CARTISSA® range from BASF, EPA registration number 71840-19) + TX; Bacillus subtilis, in particular the strain QST713 / AQ713 (SERENADE OPTI or SERENADE from Bayer CropScience LP, US). No. 6,060,051 (available as ASO, NRRL accession number B21661) +TX; Bacillus subtilis strain BU1814 (available as VELONDIS® PLUS, VELONDIS® FLEX, and VELONDIS® EXTRA from BASF SE) +TX; Bacillus subtilis var. amyloliquefaciens strain FZB24 (available as TAEGRO® or TAEGRO® ECO (EPA registration number 70127-5) from Novozymes) +TX, having accession number DSM10271; Bacillus subtilis CX-9060 +TX from Certis USA LLC (a subsidiary of Mitsui & Co., Ltd.); Bacillus sp. sp.), in particular strain D747 (available as DOUBLE NICKEL® from Kumiai Chemical Industry Co., Ltd.), having accession number FERM BP-8234, U.S. Pat. No. 7,094,592+TX; Paenibacillus sp., having accession number NRRL B-50972 or accession number NRRL B-67129) strain, WO 2016 / 154297 +TX; Paenibacillus polymyxa, in particular strain AC-1 (e.g., TOPSEED® from Green Biotech Company Ltd.) +TX; Pantoea agglomerans, in particular strain E325 (accession number NRRL B-21856) (available as BLOOMTIME BIOLOGICAL™ FD BIOPESTICIDE from Northwest Agri Products) +TX; Pseudomonas proradix from Sourcon Padena (e.g., PRORADIX®) +TX; and (1.2) Examples are fungi: Aureobasidium pullulans, in particular blastospores of the strain DSM 14940, blastospores of the strain DSM 14941 or a mixture of blastospores of the strains DSM 14940 and DSM 14941 (for example BOTECTOR® and BLOSSOM PROTECT® from bio-ferm, CH) + TX; Pseudozyma aphidis (disclosed in WO 2011 / 151819 by Yissum Research Development Company of the Hebrew University of Jerusalem) + TX; Saccharomyces cerevisiae from Lesaffre et Compagnie, FR; cerevisiae), in particular strains CNCM No. 1-3936, CNCM No. 1-3937, CNCM No. 1-3938 or CNCM No. 1-3939 (WO 2010 / 086790); (2) A biological bactericide or fungicide selected from the following group: (2.1) Examples are bacteria such as: Agrobacterium radiobacter strain K84 (e.g., GALLTROL-A® from AgBioChem, CA) + TX; Agrobacterium radiobacter strain K1026 (e.g., NOGALL® from BASF SE) + TX; Bacillus subtilis var. amyloliquefaciens strain FZB24 with accession number DSM10271 (available from Novozymes as TAEGRO® or TAEGRO® ECO (EPA registration number 70127-5)) + TX; Bacillus amyloliquefaciens, in particular strain D747 (Double No. 7,094,592, available as Nickel™, having accession number FERM BP-8234) +TX; Bacillus amyloliquefaciens strain F727 (also known as strain MBI110) (NRRL accession number B-50768, WO 2014 / 028521) (STARGUS® from Marrone Bio Innovations) +TX; Bacillus amyloliquefaciens strain FZB42, accession number DSM 23117 (available as RHIZOVITAL® from ABiTEP, DE) +TX; Bacillus amyloliquefaciens isolate B246 (e.g., from the University of AVOGREEN™ from Pretoria) +TX; Bacillus licheniformis, in particular the strain SB3086 having accession number ATCC 55406, WO 2003 / 000051 (available from Novozymes as ECOGUARD™ Biofungicide and GREEN RELEAF™) +TX +TX;Bacillus licheniformis FMCH001 and Bacillus subtilis FMCH002 (QUARTZO® (WG) and PRESENCE® (WP) from FMC Corporation) +TX; Bacillus methylotrophicus strain BAC-9912 (from the Chinese Academy of Sciences' Institute of Applied Ecology) +TX; Bacillus mojavensis strain R3B (accession number NCAIM(P)B001389) from Certis USA LLC (a subsidiary of Mitsui & Co., Ltd.) (WO 2013 / 034938) +TX; Bacillus mycoides, isolate, with accession number B-30890 (Certis Bacillus pumilus, particularly strain QST2808 (available as SONATA® from Bayer CropScience LP, US, having accession number NRRL B-30087, and described in U.S. Pat. No. 6,245,551) +TX; Bacillus pumilus, particularly strain GB34 (available as Yield Shield® from Bayer AG, DE) +TX; Bacillus pumilus, particularly strain BU F-33 having NRRL accession number 50185 (available as part of CARTISSA products from BASF, EPA registration number 71840-19) +TX; Bacillus subtilis subtilis), in particular strain QST713 / AQ713 (available from Bayer CropScience LP, US as SERENADE OPTI or SERENADE ASO, having NRRL accession number B21661, and described in US Pat. No. 6,060,051)+TX;Bacillus subtilis Y1336 (available from BioNTech, Taiwan as BIOBAC® WP, registered in Taiwan as a biological bactericide and fungicide under registration numbers 4764, 5454, 5096, and 5277) +TX; Bacillus subtilis strain MBI 600 (available from BASF SE as SUBTILEX), having accession number NRRL B-50595, U.S. Pat. No. 5,061,495 +TX; Bacillus subtilis strain GB03 (available from Bayer AG, DE as Kodiak®) +TX; Bacillus subtilis strain BU1814 (available from BASF SE as SUBTILEX), having accession number NRRL B-50595, U.S. Pat. No. 5,061,495 +TX; available as VELONDIS® PLUS, VELONDIS® FLEX, and VELONDIS® EXTRA from SE +TX; Bacillus subtilis CX-9060 +TX from Certis USA LLC (a subsidiary of Mitsui & Co., Ltd.); Bacillus subtilis KTSB strain (FOLIACTIVE® from Donaghys) +TX; Bacillus subtilis IAB / BS03 (AVIV® from STK Bio-Ag Technologies, PORTENTO® from Idai Nature) +TX; Bacillus subtilis strain Y1336 (available as BIOBAC® WP from Bion-Tech, Taiwan, registered as a biological bactericide and fungicide in Taiwan under registration numbers 4764, 5454, 5096, and 5277) + TX; Paenibacillus epiphyticus from BASF SE (WO 2016 / 020371) + TX; Paenibacillus polymyxa ssp. plantarum from BASF SE (WO 2016 / 020371) + TX;Paenibacillus sp. strains having accession number NRRL B-50972 or accession number NRRL B-67129, WO 2016 / 154297 +TX; Pseudomonas chlororaphis strain AFS009, having accession number NRRL B-50897, WO 2017 / 019448 (e.g., HOWLER™ and ZIO™ from AgBiome Innovations, US) +TX; Pseudomonas chlororaphis, in particular strain MA342 (e.g., CEDOMON™, CERALL™ and CEDRESS™ from Bioagri and Koppert) +TX; Pseudomonas fluorescens Pseudomonas fluorescens strain A506 (e.g., BLIGHTBAN® A506 by NuFarm) + TX; Pseudomonas proradix (e.g., PRORADIX® from Sourcon Padena) + TX; Streptomyces griseoviridis strain K61 (also known as Streptomyces galbus strain K61) (accession number DSM7206) (MYCOSTOP® from Verdera, PREFENCE® from BioWorks, see Crop Protection 2006, 25, 468-475) + TX; Streptomyces lydicus strain WYEC108 (Streptomyces lydicus strain WYCD108US) (ACTINO-IRON® and ACTINOVATE® manufactured by Novozymes) +TX; and (2.2) Examples of fungi are: Ampelomyces quisqualis, in particular the strain AQ 10 (for example AQ 10® from IntrachemBio Italia) + TX; Ampelomyces quisqualis strain AQ10 (for example AQ 10® from IntrachemBio Italia) with accession number CNCM1-807 + TX; Aspergillus flavus strain NRRL 21882 (product known as AFLA-GUARD® from Syngenta / ChemChina) + TX; Aureobasidium pullulans, in particular blastospores of the strain DSM 14940 + TX; Aureobasidium pullulans, in particular the strain DSM Aureobasidium pullulans, in particular a mixture of blastospores of strains DSM 14940 and DSM 14941 (e.g., Botector® by bio-ferm, CH) + TX; Chaetomium cupreum (accession number CABI 353812) (e.g., BIOKUPRUM® by AgriLife) + TX; Chaetomium globosum (available as RIVADIOM® by Rivale) + TX; Cladosporium cladosporioides, strain H39, with accession number CBS122244, as described in US Patent Application Publication No. 2010 / 0291039. Onderzoek) + TX; Coniothyrium minitans, in particular the strain CON / M / 91-8 (accession number DSM 9660, e.g. Contans® from Bayer CropScience Biologics GmbH) + TX;Cryptococcus flavescens, strain 3C (NRRL Y-50378), (B2.2.99) + TX; Dactylaria Candida + TX; Dilophosphora alopecuri (available as TWIST FUNGUS®) + TX; Fusarium oxysporum, strain Fo47 (available as FUSACLEAN® by Natural Plant Protection) + TX; Gliocladium catenulatum (synonym: Clonostachys rosea f. catenulate) strain J1446 (e.g., Prestop® by Lallemand) + TX; Gliocladium roseum) (also known as Clonostachys rosea f rosea), in particular strain 321U from the fungus Adjuvants Plus, strain ACM941 disclosed by Xue (Efficacy of Clonostachys rosea strain ACM941 and fungicide seed treatments for controlling the root tot complex of field pea, Can Jour Plant Sci 83(3):519-524) or strain IK726 (Jensen DF, et al. Development of a biocontrol agent for plant disease control with special emphasis on the near commercial fungal antagonist Clonostachys rosea strain 'IK726', Australas Plant Pathol. 2007,36:95-101) + TX;Lecanicillium lecanii (formerly known as Verticillium lecanii) conidia of the strain KV01 (e.g. Vertalec® by Koppert / Arysta) + TX; Metschnikowia fructicola, in particular the strain NRRL Y-30752, (B2.2.3) + TX; Microsphaeropsis ochracea + TX; Muscodor roseus, in particular the strain A3-5 (accession number NRRL 30548) + TX; Penicillium stickii from BASF SE steckii (DSM27859, WO 2015 / 067800) + TX; Penicillium vermiculatum + TX; Phlebiopsis gigantea strain VRA 1992 (ROTSTOP® C from Danstar Ferment) + TX; Pichia anomala, strain WRL-076 (NRRL Y-30842), U.S. Pat. No. 7,579,183 + TX; Pseudozyma flocculosa, strain PF-A22 UL (available as SPORODEX® L from Plant Products Co., CA) + TX; Saccharomyces cerevisiae, particularly strain LASO2 (Agro-Levures et Derives), strain LAS117 cell walls (CEREVISANE® from Lesaffre, ROMEO® from BASF SE), strains CNCM No. 1-3936, CNCM No. 1-3937, CNCM No. 1-3938, CNCM No. 1-3939 from Lesaffre et Compagnie, FR (WO 2010 / 086790) +TX; Simplicillium lanosoniveum +TX; Talaromyces flavus, strain V117b +TX;Trichoderma asperelloides JM41R (accession number NRRL B-50759) (TRICHO PLUS® from BASF SE) + TX; Trichoderma asperellum, in particular the strain kd (e.g. T-Gro from Andermatt Biocontrol) + TX; Trichoderma asperellum, in particular the strain SKT-1, having the accession number FERM P-16510 (e.g. ECO-HOPE® from Kumiai Chemical Industry Co., Ltd.), the strain T34 (e.g. T34 Biocontrol from Biocontrol Technologies SL, ES) or the strain ICC 012 from Isagro + TX; Trichoderma atroviride, in particular the strain SC1 (accession number CBS No. 8,431,120 (Bi-PA) having the strain 122089, strain 77B (T77 from Andermatt Biocontrol) or strain LU132 (e.g., Sentinel from Agrimm Technologies Limited) + TX; Trichoderma atroviride, strain CNCM 1-1237 (e.g., Esquive® WP from Agrauxine, FR) + TX; Trichoderma atroviride, strain number V08 / 002387 + TX; Trichoderma atroviride, strain NMI number V08 / 002388 + TX; Trichoderma atroviride, strain NMI number V08 / 002389 + TX; atroviride), strain NMI number V08 / 002389+TX; Trichoderma atroviride, strain NMI number V08 / 002390+TX; Trichoderma atroviride, strain LC52 (e.g. Tenet by Agrimm Technologies Limited)+TX;Trichoderma atroviride, strain ATCC 20476 (IMI 206040) + TX; Trichoderma atroviride, strain T11 (IMI352941 / CECT20498) + TX; Trichoderma atroviride, strain SKT-1 (FERM P-16510), JP 11-253151 A + TX; Trichoderma atroviride, strain SKT-2 (FERM P-16511), JP 11-253151 A + TX; Trichoderma atroviride; strain SKT-3 (FERM P-17021), JP 11-253151 A + TX; Trichoderma fertile (e.g., the product TrichoPlus from BASF) + TX; Trichoderma gamsii (formerly T. viride), strain ICC080 (IMI CC 392151 CABI, e.g., BioDerma from AGROBIOSOL DE MEXICO, SADE CV) + TX; Trichoderma gamsii (formerly T. viride), strain ICC 080 (IMI CC 392151 CABI) (available as BIODERMA® from AGROBIOSOL DE MEXICO, SADE CV) + TX; Trichoderma harmatum harmatum + TX; Trichoderma harmatum with accession number ATCC 28012 + TX; Trichoderma harzianum strain T-22 (e.g. Trianum-P from Andermatt Biocontrol or Koppert) or strain Cepa SimbT5 (Simbiose Agro) + TX; Trichoderma harzianum + TX; Trichoderma harzianum rifai T39 (e.g. Trichodex® from Makhteshim, US) + TX; Trichoderma harzianum, strain ITEM 908 (e.g. Trianum-P from Koppert) + TX; Trichoderma harzianum, strain TH35 (e.g., Root-Pro by Mycontrol) + TX; Trichoderma harzianum, strain DB 103 (available as T-GRO® 7456 by Dagutat Biolab) + TX;Trichoderma polysporum, strain IMI 206039 (e.g., Binab TF WP by BINAB Bio-Innovation AB, Sweden) + TX; Trichoderma stromaticum, with accession number Ts3550 (e.g., Tricovab by CEPLAC, Brazil) + TX; Trichoderma virens (also known as Gliocladium virens), in particular strain GL-21 (e.g., SoilGard by Certis, US) + TX; Trichoderma virens strain G-41, formerly known as Gliocladium virens (accession number ATCC 20906) (e.g. ROOTSHIELD® PLUS WP and TURFSHIELD® PLUS WP from BioWorks, US) +TX; Trichoderma viride, strain TV1 (e.g. Trianum-P by Koppert) +TX; Trichoderma viride, in particular strain B35 (Pietr et al., 1993, Zesz. Nauk. AR w Szczecinie 161:125-137) +TX; Trichoderma asperellum strain ICC 012 (also known as Trichoderma harzianum ICC012), having the accession number CABI CC IMI 392716; gamsii (formerly T. viride) strain ICC 080, accession number IMI 392151 (e.g., a mixture of BIO-TAM™ from Isagro USA, Inc. and BIODERMA® from Agrobiosol de Mexico, SA de CV) + TX;Ulocladium oudemansii strain U3 with accession number NM 99 / 06216 (e.g., BOTRY-ZEN® by Botry-Zen Ltd, New Zealand and BOTRYSTOP® from BioWorks, Inc.) +TX; Verticillium albo-atrum (formerly V. dahliae), strain WCS850 with accession number WCS850, deposited at the Central Bureau for Fungi Cultures (e.g., DUTCH TRIG® from Tree Care Innovations) +TX; Verticillium chlamydosporium +TX; (3) A biological control agent having the effect of improving plant growth and / or plant health selected from the following group: (3.1) Examples of bacteria include Azospirillum brasilense (e.g., VIGOR® from KALO, Inc.) + TX; Azospirillum lipoferum (e.g., VERTEX-IF® from TerraMax, Inc.) + TX; Azorhizobium caulinodans, in particular the strain ZB-SK-5 + TX; Azotobacter chroococcum, in particular the strain H23 + TX; Azotobacter vinelandii, in particular the strain ATCC 12837 + TX; Azotobacter vinelandii and Clostridium pasteurianum a mixture of Bacillus pasteurianum (available from Agrinos as INVIGORATE®) + TX; Bacillus amyloliquefaciens pm414 (LOLI-PEPTA® from Biofilm Crop Protection) + TX; Bacillus amyloliquefaciens SB3281 (ATCC #PTA-7542, WO 2017 / 205258) + TX; Bacillus amyloliquefaciens TJ1000 (available from Novozymes as QUIKROOTS®) + TX; Bacillus Bacillus amyloliquefaciens, in particular the strain IN937a + TX; Bacillus amyloliquefaciens, in particular the strain FZB42 (e.g. RHIZOVITAL® from ABiTEP, DE) + TX; Bacillus amyloliquefaciens BS27 (accession number NRRL B-5015) + TX;Bacillus cereus family member EE128 (NRRL No. B-50917) + TX; Bacillus cereus family member EE349 (NRRL No. B-50928) + TX; Bacillus cereus, particularly strain BP01 (ATCC 55675, e.g., MEPICHLOR® from Arysta Lifescience, US) + TX; Bacillus firmus, particularly strain CNMC 1-1582 (e.g., VOTIVO® from BASF SE) + TX; Bacillus mycoides BT155 (NRRL No. B-50921) + TX; Bacillus mycoides EE118 (Bacillus mycoides Bacillus mycoides EE118 (NRRL No. B-50918) + TX; Bacillus mycoides EE141 (NRRL No. B-50916) + TX; Bacillus mycoides BT46-3 (NRRL No. B-50922) + TX; Bacillus pumilus, in particular strain QST2808 (Accession No. NRRL No. B-30087) + TX; Bacillus pumilus, in particular strain GB34 (e.g., YIELD SHIELD® from Bayer Crop Science, DE) + TX; Bacillus siamensis, in particular strain KCTC 13613T + TX; Bacillus subtilis subtilis, particularly strain QST713 / AQ713 (having NRRL accession number B-21661 and described in U.S. Pat. No. 6,060,051, available from Bayer CropScience LP, US as SERENADE® OPTI or SERENADE® ASO) + TX; Bacillus subtilis, particularly strain AQ30002 (having NRRL accession number B-50421 and described in U.S. Patent Application Publication No. 13 / 330,576) + TX;Bacillus subtilis, particularly strain AQ30004 (and described in NRRL B-50455 and U.S. Patent Application Publication No. 13 / 330,576) +TX; Bacillus subtilis strain BU1814, (available as TEQUALIS® from BASF SE), Bacillus subtilis rm303 (RHIZOMAX® from Biofilm Crop Protection) +TX; Bacillus thuringiensis BT013A (NRRL No. B-50924) (also known as Bacillus thuringiensis 4Q7) +TX; Bacillus licheniformis FMCH001 (Bacillus licheniformis a mixture of Bacillus subtilis FMCH001 and Bacillus subtilis FMCH002 (available from FMC Corporation as QUARTZO® (WG), PRESENCE® (WP)) + TX; Bacillus subtilis, particularly the strain MBI 600 (e.g., SUBTILEX® from BASF SE) + TX; Bacillus tequilensis, particularly the strain NII-0943 + TX; Bradyrhizobium japonicum (e.g., OPTIMIZE® from Novozymes) + TX; Delftia acidovorans, particularly the strain RAY209 (e.g., BIOBOOST® from Brett Young Seeds) + TX; Mesorhizobium Lactobacillus sp. (e.g., LACTOPLANT® from LactoPAFI) + TX;Rhizobium leguminosarium biovar viciae (e.g. NODULATOR from BASF SE) + TX; Pseudomonas proradix (e.g. PRORADIX® from Sourcon Padena) + TX; Pseudomonas aeruginosa, in particular the strain PN1 + TX; Rhizobium leguminosarum, in particular the bv. viciae strain Z25 (accession number CECT 4585) + TX; Paenibacillus polymyxa, in particular the strain AC-1 (e.g. TOPSEED® from Green Biotech Company Ltd.) + TX; Serratia marcescens, in particular the strain SRM (accession number MTCC 8708) +TX; Sinorhizobium meliloti strain NRG-185-1 (NITRAGIN® GOLD from Bayer CropScience) +TX; Bacillus sp. (e.g., CROPAID® from Cropaid Ltd UK) +TX; and (3.2) Examples of fungi are: Purpureocillium lilacinum (formerly known as Paecilomyces lilacinus), strain 251 (AGAL 89 / 030550, e.g. BioAct from Bayer CropScience Biologics GmbH) +TX; Penicillium bilaii, strain ATCC 22348 (e.g. JumpStart® from Acceleron BioAg), Talaromyces flavus, strain V117b +TX; Trichoderma atroviride, strain CNCM 1-1237 (e.g. Esquive® WP from Agrauxine, FR), Trichoderma viride ... viride), e.g., strain B35 (Pietr et al., 1993, Zesz. Nauk.AR w Szczecinie 161:125-137) + TX; Trichoderma atroviride strain LC52 (also known as Trichoderma atroviride strain LU132, e.g. Sentinel from Agrimm Technologies Limited) + TX; Trichoderma atroviride strain SC1 as described in International Patent Application PCT / ITA Publication No. 2008 / 000196 + TX; Trichoderma asperellum strain kd (e.g. T-Gro from Andermatt Biocontrol) + TX; Trichoderma asperellum strain Eco-T (Plant Health Products, ZA), Trichoderma harzianum harzianum strain T-22 (e.g. Trianum-P from Andermatt Biocontrol or Koppert) + TX; Myrothecium verrucaria strain AARC-0255 (e.g. DiTera™ from Valent Biosciences) + TX; Penicillium bilaii strain ATCC ATCC20851 + TX; Pythium oligandrum strain M1 (ATCC38472, e.g. Polyversum from Bioprepraty, CZ) + TX; Trichoderma virens strain GL-21 (e.g. SoilGard™ from Certis, USA) + TX; Verticillium alboatrum albo-atrum (formerly V. dahliae) strain WCS850 (CBS276).92, e.g. Dutch Trig from Tree Care Innovations) +TX; Trichoderma atroviride, in particular strain number V08 / 002387, strain number NMI number V08 / 002388, strain number NMI number V08 / 002389, strain number NMI number V08 / 002390 +TX; Trichoderma harzianum strain ITEM 908, Trichoderma harzianum, strain TSTh20 +TX; Trichoderma harzianum strain 1295-22 +TX; Pythium oligandrum strain DV74 +TX; Rhizopogon amylopogon amylopogon (e.g., contained in Myco-Sol from Helena Chemical Company) + TX; Rhizopogon fulvigleba (e.g., contained in Myco-Sol from Helena Chemical Company) + TX; Trichoderma virens strain GI-3 + TX; (4) an insecticidally effective biological control agent selected from the following: (4.1) Examples are bacteria: Agrobacterium radiobacter strain K84 (Galltrol from AgBiochem Inc.) + TX; Bacillus amyloliquefaciens, in particular the strain PTS-4838 (e.g. AVEO from Valent Biosciences, US) + TX; Bacillus firmus, in particular the strain CNMC1-1582 (e.g. VOTIVO® from BASF SE) + TX; Bacillus mycoides, isolate J. (e.g. BmJ from Certis USA LLC (a subsidiary of Mitsui & Co., Ltd.)) + TX; Bacillus sphaericus, in particular the serotype H5a5b strain 2362 (strain ABTS-1743) (e.g. Valent Biosciences, US) + TX; BioSciences, US) + TX; Bacillus thuringiensis subsp. aizawai, in particular the strain ABTS-1857 (SD-1372, e.g., XENTARI® from Valent BioSciences) + TX; Bacillus thuringiensis subsp. aizawai, in particular the serotype H-7 (e.g., FLORBAC® WG from Valent BioSciences, US) + TX; Bacillus thuringiensis israelensis strain BMP 144 (e.g., AQUABAC® from Becker Microbial Products, IL) + TX; Bacillus thuringiensis subsp.israelensis (serotype H-14) strain AM65-52 (accession number ATCC 1276) (e.g., VECTOBAC® from Valent BioSciences, US) +TX; Bacillus thuringiensis subsp. aizawai strain GC-91 +TX; Bacillus thuringiensis var. colmeri (e.g., TIANBAOBTC from Changzhou Jianghai Chemical Factory) +TX; Bacillus thuringiensis var. japonensis strain Buibui +TX; Bacillus thuringiensis subsp. kurstaki strain BMP 123 +TX from Becker Microbial Products, IL; Bacillus thuringiensis subsp. kurstaki strain BMP 123 by Bayer CropScience Products, IL, e.g., BARITONE + TX from Bayer CropScience; Bacillus thuringiensis subsp. kurstaki strain HD-1 (e.g., DIPEL® ES from Valent BioSciences, US) + TX; Bacillus thuringiensis var. kurstaki strain EVB-113-19 (e.g., BIOPROTEC® from AEF Global) + TX; Bacillus thuringiensis subsp. kurstaki strain ABTS351 + TX; Bacillus thuringiensis subsp. kurstaki strain PB 54+TX; Bacillus thuringiensis subsp.kurstaki strain SA 11 (JAVELIN from Certis, US) + TX; Bacillus thuringiensis subsp. kurstaki strain SA 12 (THURICIDE from Certis, US) + TX; Bacillus thuringiensis subsp. kurstaki strain EG2348 (LEPINOX from Certis, US) + TX; Bacillus thuringiensis subsp. kurstaki strain EG 7841 (CRYMAX from Certis, US) + TX; Bacillus thuringiensis subsp. tenebrionis strain NB176 (SD-5428, e.g., BioFa NOVODOR® FC from DE) + TX; Brevibacillus laterosporus (LATERAL from Ecolibrium Biologicals) + TX; Burkholderia spp.), in particular Burkholderia rinojensis strain A396 (also known as Burkholderia rinojensis strain MBI 305) (Accession No. NRRL B-50319 +TX; WO 2011 / 106491 and WO 2013 / 032693 +TX; e.g. MBI206 TGAI and ZELTO® +TX from Marrone Bio Innovations); Chromobacterium subtsugae, in particular strain PRAA4-1T (MBI-203 +TX; e.g. GRANDEVO® from Marrone Bio Innovations) +TX; Lecanicillium muscarium Ve6 (Lecanicillium muscarium Ve6) (MYCOTAL from Koppert) + TX; Paenibacillus popilliae (formerly Bacillus popilliae) + TX; e.g., MILKY SPORE POWDER™ and MILKY SPORE GRANULAR™ from St. Gabriel Laboratories + TX; Pasteuria nishizawae strain Pn1 (CLARIVA from Syngenta / ChemChina) + TX; Serratia entomophila (e.g., INVADE® by Wrightson Seeds) + TX; Serratia marcescens, particularly strain SRM (accession number MTCC 8708) + TX; Trichoderma asperellum asperellum (TRICHODERMAX from Novozymes) + TX; Wolbachia pipientis ZAP strain (e.g., ZAP MALES® from MosquitoMate) + TX; and (4.2) Examples of fungi are: Beauveria bassiana strain ATCC 74040 (e.g. NATURALIS® from Intrachem Bio Italia) + TX; Beauveria bassiana strain GHA (accession number ATCC 74250, e.g. BOTANIGUARD® ES and MYCONTROL-O® from Laverlam International Corporation) + TX; Beauveria bassiana strain ATP02 (accession number DSM24665) + TX; Isaria fumosorosea (formerly known as Paecilomyces fumosoroseus) strain Apopka 97 from SePRO (PREFERAL) + TX; Metarhizium anisopliae anisopliae 3213-1 (deposited under NRRL accession number 67074) (WO 2017 / 066094 +TX; Pioneer Hi-Bred International) +TX; Metarhizium robertsii 15013-1 (deposited under NRRL accession number 67073) +TX; Metarhizium robertsii 23013-3 (deposited under NRRL accession number 67075) +TX; Paecilomyces lilacinus strain 251 (MELOCON from Certis, US) +TX; Zoophtora radicans +TX; (5) A virus selected from the group consisting of: Adoxophyes orana (smaller apple tortrix) granulosis virus (GV) + TX; Cydia pomonella (codling moth) granulosis virus (GV) + TX; Helicoverpa armigera (cotton bollworm) nucleopolyhedrovirus (NPV) + TX; Spodoptera exigua (beet armyworm) mNPV + TX; Spodoptera frugiperda (stalk armyworm) mNPV + TX; Spodoptera littoralis (Egyptian armyworm) NPV + TX; (6) Bacteria and fungi that can be added as "inoculants" to plants or plant parts or plant tissues and that promote plant growth and plant health due to their specific properties, selected from the following: Agrobacterium spp. + TX; Azorhizobium caulinodans + TX; Azospirillum spp. + TX; Azotobacter spp. + TX; Bradyrhizobium spp. + TX; Burkholderia spp., especially Burkholderia cepacia (formerly known as Pseudomonas cepacia) + TX; Gigaspora spp. spp.) or Gigaspora monosporum + TX; Glomus spp. + TX; Laccaria spp. + TX; Lactobacillus buchneri + TX; Paraglomus spp. + TX; Pisolithus tinctorus + TX; Pseudomonas spp. + TX; Rhizobium spp., especially Rhizobium trifolii + TX; Rhizopogon spp. + TX; Scleroderma spp. + TX; Suillus spp.) + TX;Streptomyces spp.) + TX; (7) Plant extracts and products formed by microorganisms containing proteins and secondary metabolites that can be used as biological control agents, selected from the following: garlic (Allium sativum) (NEMGUARD from Eco-Spray) + TX; BRALIC from ADAMA) + TX; Armour-Zen + TX; Artemisia absinthium + TX; azadirachtin (e.g., AZATIN XL from Certis, US) + TX; Biokeeper WP + TX; Brassicaceae extracts, in particular rapeseed powder or mustard powder + TX; Cassia nigricans + TX; Celastrus angulatus + TX; Chenopodium anthelminticum + TX; chitin + TX; Dryopteris filix-mas + TX; Equisetum arvense) + TX; Fortune Aza + TX; Fungastop + TX; Heads Up (quinoa (Chenopodium quinoa) saponin extract) + TX; PROBLAD (natural Blad polypeptide derived from lupine seeds), Certis EU + TX; FRACTURE (natural Blad polypeptide derived from lupine seeds), FMC + TX; Calystegia / pyrethrin + TX; Quassia amara + TX; Quercus + TX; Quillaja extract (QL AGRI 35 from BASF) + TX; Reynoutria sachalinensis extract (REGALLIA / REGALIA MAXX from Marrone Bio) + TX; Requiem™ Insecticide + TX; Rotenone + TX; Ryania / Ryanodine + TX; Comfrey (Symphytum officinale) + TX; Tansy (Tanacetum vulgare) + TX; Thymol + TX; Thymol mixed with geraniol (CEDROZ from Eden Research) + TX;Thymol mixed with geraniol and eugenol (MEVALONE from Eden Research) +TX; Triact 70 +TX; TriCon +TX; nasturtium (Tropaeulum majus) +TX; Melaleuca alternifolia extract (TIMOREX GOLD from STK) +TX; nettle (Urtica dioica) +TX; veratrine +TX; and mistletoe (Viscum album) +TX; and Safeners such as benoxacor + TX, cloquintocet (including cloquintocet-mexyl) + TX, cyprosulfamide + TX, dichlormid + TX, fenchlorazole (including fenchlorazole-ethyl) + TX, fenclorim + TX, fluxofenim + TX, furilazole + TX, isoxadifen (including isoxadifen-ethyl) + TX, mefenpyr (including mefenpyr-diethyl) + TX, metcamifen + TX and oxabetrinil + TX.

[0330] The reference numbers in square brackets after the active ingredient, such as [3878-19-1], refer to the Chemical Abstracts Registration Number. The above-mentioned compounds are known. When the active ingredients are included in "The Pesticide Manual" [The Pesticide Manual - A World Compendium; Thirteenth Edition; Editor: CDS Tomlin; The British Crop Protection Council], they are listed therein under the section number shown in parentheses above for the specific compound; for example, the compound "abamectin" is listed under section number (1). When "[CCN]" is added to a specific compound above, the corresponding compound is included in the "Compendium of Pesticide Common Names," which is accessible on the Internet [A. Wood; Compendium of Pesticide Common Names, (Copyright) 1995-2004]; for example, the compound "acetoprole" is listed at the Internet address: http: / / www.alanwood.net / pesticides / acetoprole.html.

[0331] Most of the active ingredients mentioned above are referred to above by so-called "common names", and the relevant "ISO common names" or another "common name" is used in individual cases. If the designation is not a "common name", the nature of the designation used instead is indicated in parentheses for the particular compound; in that case, the IUPAC name, IUPAC / Chemical Abstracts name, "chemical name", "trivial name", "compound name" or "development code" is used, or if neither one of these designations nor a "common name" is used, an "alternative name" is used. "CAS Registry Number" means the Chemical Abstracts Registry Number.

[0332] The active ingredient mixture of a compound of formula (I) selected from the compounds defined in Tables 1 to 81 and Tables P1 to P6 with the above-mentioned active ingredient is preferably a mixture of a compound selected from one of the compounds defined in Tables 1 to 81 and Tables P1 to P6 and the above-mentioned active ingredient in a mixing ratio of 100:1 to 1:6000, in particular 50:1 to 1:50, more in particular 20:1 to 1:20, even more in particular 10:1 to 1:10, very in particular 5:1 and 1:5 (a ratio of 2:1 to 1:2 is particularly preferred, a ratio of 4:1 to 2:1 is also preferred), in particular 1:1, or 5:1, or 5:2, or 5:3. , or 5:4, or 4:1, or 4:2, or 4:3, or 3:1, or 3:2, or 2:1, or 1:5, or 2:5, or 3:5, or 4:5, or 1:4, or 2:4, or 3:4, or 1:3, or 2:3, or 1:2, or 1:600, or 1:300, or 1:150, or 1:35, or 2:35, or 4:35, or 1:75, or 2:75, or 4:75, or 1:6000, or 1:3000, or 1:1500, or 1:350, or 2:350, or 4:350, or 1:750, or 2:750, or 4:750. These mixing ratios are by weight.

[0333] The mixture may be used in a method for controlling pests, the method comprising the step of applying a composition comprising the mixture to the pest or its environment, excluding methods of treatment of the human or animal body by surgery or therapy and diagnostic methods performed on the human or animal body.

[0334] Mixtures comprising a compound of formula (I) selected from the compounds defined in Tables 1 to 81 and Tables P1 to P6 and one or more of the active ingredients described above can be applied, for example, in a single ready-mix form, as a combined spray mixture composed of separate formulations of a single active ingredient, such as a "tank mix," and in combination with a single active ingredient when applied sequentially, i.e., one after the other over a fairly short period of time, such as a few hours or days. The order in which the compound of formula (I) and the active ingredients described above are applied is not critical to carrying out the present invention.

[0335] The compositions according to the invention may also comprise further solid or liquid auxiliaries, such as stabilizers, for example non-epoxidized or epoxidized vegetable oils (for example epoxidized palm oil, rapeseed oil or soybean oil), antifoaming agents, for example silicone oils, preservatives, viscosity regulators, binders and / or tackifiers, fertilizers or other active ingredients for achieving specific effects, for example bactericides, fungicides, nematicides, plant activators, molluscicides or herbicides.

[0336] The compositions according to the invention are prepared in a manner known per se in the absence of auxiliaries, for example by grinding, sieving and / or compressing the solid active ingredient, and in the presence of at least one auxiliary, for example by intimately mixing the active ingredient with one or more auxiliaries and / or grinding it. These methods for preparing the compositions and the use of compound I for preparing these compositions are also the subject of the present invention.

[0337] The application methods for the compositions, i.e., spraying, atomizing, dusting, brushing, dusting, spreading, or pouring (which should be selected according to the intended purpose in the prevailing situation), are other subjects of the present invention. Typical concentration rates are 0.1 to 1000 ppm, preferably 0.1 to 500 ppm, of active ingredient. The application rate per hectare is generally 1 to 2000 g of active ingredient per hectare, in particular 10 to 1000 g / ha, preferably 10 to 600 g / ha.

[0338] The preferred method of application in the field of crop protection is application to the foliage of plants (foliar application), and the frequency and rate of application can be selected according to the risk of infestation by the relevant pest. Alternatively, the active ingredient can reach the plant via the root system (systemic action) by irrigating the plant habitat with a liquid composition or by introducing the active ingredient in solid form into the plant habitat, for example, the soil, for example in the form of granules (soil application). In the case of paddy rice plants, such granules can be metered into the paddy field.

[0339] The compounds of formula (I) of the present invention and compositions thereof are also suitable for protecting plant propagation material, such as seeds or seedlings of fruits, tubers, or grains, from the above-mentioned types of pests. The propagation material can be treated with the compounds before planting, for example, seeds can be treated before sowing. Alternatively, the compounds can be applied to the seed kernels by immersing them in a liquid composition or by applying a layer of a solid composition (coating). When the propagation material is planted at the application site, the compositions can also be applied between the furrows, for example, during drilling. These treatment methods for plant propagation material and the plant propagation material thus treated are further subjects of the present invention. Typical treatment rates depend on the plant and the pests / fungi to be controlled and are generally 1 to 200 grams per 100 kg of seeds, preferably 5 to 150 grams per 100 kg of seeds (e.g., 10 to 100 grams per 100 kg of seeds).

[0340] The term seed encompasses all types of seeds and plant propagules, including but not limited to true seeds, seed pieces, suckers, kernels, bulbs, fruits, tubers, grains, rhizomes, cuttings, cuttings, etc., and in preferred embodiments refers to true seeds.

[0341] The present invention also includes seeds coated or treated with or containing a compound of formula I. The term "coated or treated with and / or containing" generally indicates that the active ingredient is most often on the surface of the seed upon application, but that depending on the application method, some of the ingredient may penetrate to varying degrees into the seed material. When the seed product is (re)planted, it may absorb the active ingredient. In one embodiment, the present invention makes available plant propagation material having a compound of formula I attached thereto. Furthermore, this makes available compositions comprising plant propagation material treated with a compound of formula I.

[0342] Seed treatment includes all suitable seed treatment techniques known in the art, such as seed dressing, seed coating, seed dusting, seed soaking, and seed pelleting. The seed treatment application of the compound of formula (I) can be carried out by any known method, such as by spraying or dusting the seeds before sowing or at the time of sowing / planting the seeds.

[0343] The compounds of the present invention can be distinguished from other similar compounds by their greater efficacy at low application rates and / or by different pest control, which can be achieved, if desired, at lower concentrations, e.g., 10 ppm, 5 ppm, 2 ppm, 1 ppm or 0.2 ppm; or 300, 200 or 100 mg AI / m 2 Higher efficacy can be observed by a person skilled in the art using experimental techniques using lower application rates, such as: Higher efficacy can be observed by a higher safety profile (improved physicochemical properties or higher biodegradability to above- and below-ground non-target organisms, such as fish, birds, and bees).

[0344] In each aspect and embodiment of the present invention, "consisting essentially of" and variations thereof is a preferred embodiment of "comprising" and variations thereof, and "consisting of" and variations thereof is a preferred embodiment of "consisting essentially of" and variations thereof.

[0345] The present disclosure makes available any and all combinations of the embodiments disclosed herein.

[0346] Biological Examples: The following examples illustrate the invention. Certain compounds of the invention can be distinguished from known compounds by their high efficacy at low application rates, which can be verified by those skilled in the art using the experimental procedures outlined in the examples, using lower application rates, such as 50 ppm, 24 ppm, 12.5 ppm, 6 ppm, 3 ppm, 1.5 ppm, 0.8 ppm or 0.2 ppm, if necessary.

[0347] Example B1: Tetranychus urticae (Tetranychus urticae): Feeding / contact activity Green bean leaf discs on agar in 24-well microtiter plates were sprayed with test solutions prepared from a 10,000 ppm DMSO stock solution. After drying, the discs were infested with mite individuals of various ages. Eight days after infestation, samples were assessed for mortality against the mixed population (active phase).

[0348] The following compounds caused at least 80% mortality at 200 ppm: P1.1, P1.2., P1.3, P1.4, P1.5, P1.6, P1.7, P1.8, P1.9, P1.10, P1.11, P1.12, P1.13, P1.14, P1.15, P1.18, P1.20, P1. 22, P1.23, P1.24, P1.25, P1.26, P1.27, P1.28, P1.29, P1.30, P1.31, P1.32, P1.34, P1.36, P1.37, P1.38, P1.39, P1.40 , P1.41, P1.43, P1.44, P1.46, P1.47, P1.48, P1.49, P1.51, P1.52, P1.53, P1.55, P1.56, P1.59, P2.1, P2.2, P2.3, P2.4 , P2.5, P6.1, P6.3, P6.4, P6.7, P6.11, P6.16, P6.21, P6.24, P6.31, P6.37, P6.38, P6.41, P6.50, P6.51, P6.52, P6.53.

Claims

1. Compounds of formula (I) 【Chemistry 1】 (In the formula, R 1 is CN or C(=S)NH 2 and R 2 H, OH, halogen, C 1 ~C 6 -Alkoxy or C 1 ~C 6 -haloalkoxy; R 3 is C 1 ~C 6 -Alkoxy-C 1 ~C 6 -Alkyl, C 1 ~C 6 -haloalkoxy-C 1 ~C 6 -Alkyl, C 2 ~C 6 -Alkenyloxy-C 1 ~C 6 -Alkyl, C 2 ~C 6 -haloalkenyloxy-C 1 ~C 6 -Alkyl, C 2 ~C 6 -Alkynyloxy-C 1 ~C 6 -Alkyl, C 2 ~C 6 -haloalkynyloxy-C 1 ~C 6 -Alkyl, C 3 ~C 6 -Cycloalkoxy-C 1 ~C 6 -Alkyl, C 3 ~C 6 -Halocycloalkoxy-C 1 ~C 6 -Alkyl, C 1 ~C 6 -Alkylsulfonyl-C 1 ~C 6 - alkyl; C 1 ~C 6 -Alkylsulfonyl-C 3 ~C 6 -Cycloalkyl, C 1 ~C 6 -cyanoalkyl or C 3 ~C 6 -cyanocycloalkyl; R 4 is C 1 ~C 6 -Haloalkyl, C 2 ~C 6 -Alkenyl, C 2 ~C 6 -haloalkenyl, C 3 ~C 6 -Cycloalkyl, C 3 ~C 6 -halocycloalkyl, phenyl, 1 to 3 independently selected substituents R 5 phenyl, heteroaryl (either 5- or 6-membered monocyclic or 8-, 9- or 10-membered bicyclic), 1 to 3 independently selected substituents R 6 heteroaryl (either 5- or 6-membered monocyclic or 8-, 9- or 10-membered bicyclic), phenyl-C 1 ~C 3 -alkyl or 1 to 3 independently selected substituents R 7 Phenyl-C substituted with 1 ~C 3 - alkyl; Q is a cyclic amine represented by formula IIa or a cyclic amine represented by formula IIb 【Chemistry 2】 (wherein the arrow indicates the connection to the carbonyl group; p 1 is 0, 1 or 2 and indicates the number of methylene groups; p 2 is 0, 1 or 2 and indicates the number of methylene groups; q 1 is 1 or 2 and indicates the number of methylene groups; q 2 is 1 or 2 and indicates the number of methylene groups; X is hydrogen, hydroxyl, alkoxy or halogen; Y is cyano, C 1 ~C 6 -Alkyl, C 1 ~C 6 -Alkoxy-C 1 ~C 6 -Alkyl, C 1 ~C 6 -Alkyl sulfanyl-C 1 ~C 6 -Alkyl, C 1 ~C 6 -Alkyl sulfinyl-C 1 ~C 6 -Alkyl, C 1 ~C 6 -Alkylsulfonyl-C 1 ~C 6 -Alkyl, C 3 ~C 6 -Alkenylsulfanyl-C 1 ~C 6 -Alkyl, C 3 ~C 6 -Alkenylsulfinyl-C 3 ~C 6 -Alkyl, C 3 ~C 6 -Alkenylsulfonyl-C 1 ~C 6 -Alkyl, C 3 ~C 6 -Alkynylsulfanyl-C 1 ~C 6 -Alkyl, C 3 ~C 6 -Alkynylsulfinyl-C 1 ~C 6 -Alkyl, C 1 ~C 6 -Alkynylsulfonyl-C 1 ~C 6 -alkyl, R a R b N.C. (O), R c C(O)NR d , R e SO 2 N.R. f , R g O-N=CR h , a 4-6 membered non-aromatic heterocyclic ring system in which 1 or 2 carbons are independently replaced with nitrogen, oxygen, sulfur or sulfonyl, phenyl, 1 to 3 independently selected substituents R 8 phenyl, 5- or 6-membered monocyclic heteroaryl, or one to three independently selected substituents R 9 is a 5- or 6-membered monocyclic heteroaryl substituted with A is cyano, C is 1 ~C 6 -cyanoalkyl, C 2 ~C 6 -cyanoalkenyl, C 3 ~C 6 -cyanocycloalkyl, C 1 ~C 6 -Haloalkyl, C 1 ~C 6 -haloalkenyl, C 3 ~C 6 -Halocycloalkyl, C 1 ~C 6 -alkoxycarbonyl, C 2 ~C 6 -alkenyloxycarbonyl, C 2 ~C 6 -alkynyloxycarbonyl, C 1 ~C 6 -Alkyl sulfanyl-C 1 ~C 6 -Alkyl, C 1 ~C 6 -Alkyl sulfinyl-C 1 ~C 6 -Alkyl, C 1 ~C 6 -Alkylsulfonyl-C 1 ~C 6 -alkyl, R i SO 2 , R j R k NSO 2 , phenyl, 1 to 3 independently selected substituents R 10 phenyl, heteroaryl (either 5- or 6-membered monocyclic or 8-, 9- or 10-membered bicyclic), or one to three independently selected substituents R 11 Heteroaryl substituted with (either 5- or 6-membered monocyclic or 8-, 9- or 10-membered bicyclic) and R a , R b , R c , R d , R f , R g , R h , R j and R k is hydrogen, C 1 ~C 6 -Alkyl, C 1 ~C 6 -Haloalkyl, C 2 ~C 6 -Alkenyl, C 2 ~C 6 -haloalkenyl, C 2 ~C 6 -Alkynyl, C 2 ~C 6 -haloalkynyl, C 3 ~C 6 -Cycloalkyl and C 3 ~C 6 -halocycloalkyl; R e and R i is C 1 ~C 6 -Alkyl, C 1 ~C 6 -Haloalkyl, C 2 ~C 6 -Alkenyl, C 2 ~C 6 -haloalkenyl, C 2 ~C 6 -Alkynyl, C 2 ~C 6 -haloalkynyl, C 3 ~C 6 -Cycloalkyl and C 3 ~C 6 -halocycloalkyl; R 5 is halogen, cyano, C 1 ~C 6 -Alkyl, C 1 ~C 6 -Haloalkyl, C 2 ~C 6 -Alkenyl, C 2 ~C 6 -haloalkenyl, C 2 ~C 6 -Alkynyl, C 2 ~C 6 -haloalkynyl, C 3 ~C 6 -Cycloalkyl, C 3 ~C 6 -Halocycloalkyl, C 1 ~C 6 -Alkoxy, C 1 ~C 6 -Haloalkoxy, C 1 ~C 6 -Alkylsulfonyl, C 1 ~C 6 -haloalkylsulfanyl and -O-C 1-2 haloalkanediyl-O-; and R 6 , R 7 , R 8 , R 9 , R 10 , R 11 is halogen, cyano, C 1 ~C 6 -Alkyl, C 1 ~C 6 -Haloalkyl, C 2 ~C 6 -Alkenyl, C 2 ~C 6 -haloalkenyl, C 2 ~C 6 -Alkynyl, C 2 ~C 6 -haloalkynyl, C 3 ~C 6 -Cycloalkyl, C 3 ~C 6 -Halocycloalkyl, C 1 ~C 6 -Alkoxy, C 1 ~C 6 -Haloalkoxy, C 1 ~C 6 -Alkylsulfonyl and C 1 ~C 6 -haloalkylsulfanyl) or agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of the compounds of formula (I).

2. R 1 The compound of claim 1 , wherein is CN.

3. R 2 is H. The compound of claim 1 or claim 2.

4. R 3 is C 1 ~C 4 -Alkoxy-C 1 ~C 3 -Alkyl, C 1 ~C 4 -haloalkoxy-C 1 ~C 3 -Alkyl, C 2 ~C 4 -Alkenyloxy-C 1 ~C 3 -Alkyl, C 2 ~C 4 -haloalkenyloxy-C 1 ~C 3 -Alkyl, C 2 ~C 4 -Alkynyloxy-C 1 ~C 3 -Alkyl, C 2 ~C 4 -haloalkynyloxy-C 1 ~C 3 -Alkyl, C 3 ~C 6 -Cycloalkoxy-C 1 ~C 3 -Alkyl, C 3 ~C 6 -Halocycloalkoxy-C 1 ~C 3 -Alkyl, C 1 ~C 4 -Alkylsulfonyl-C 1 ~C 3 - alkyl; C 1 ~C 4 -Alkylsulfonyl-C 3 ~C 6 -Cycloalkyl, C 1 ~C 4 -cyanoalkyl or C 3 ~C 6 The compound according to any one of claims 1 to 3, wherein the aryl group is -cyanocycloalkyl.

5. R 4 is C 1 ~C 6 Haloalkyl, C 2 ~C 6 Alkenyl, C 2 ~C 6 Haloalkenyl, C 3 ~C 6 Cycloalkyl, C 3 ~C 6 halocycloalkyl, phenyl, 1 to 3 substituents R 5 phenyl substituted with 5- or 6-membered monocyclic heteroaryl; 6 5- or 6-membered monocyclic heteroaryl substituted with phenyl-C 1 ~C 3 alkyl or 1 to 3 substituents R 7 Phenyl-C substituted with 1 ~C 3 alkyl, where R 5 , R 6 and R 7 The compound according to any one of claims 1 to 4, wherein is as defined in claim 1.

6. R 4 is 1 to 3 substituents R 5 The compound according to any one of claims 1 to 5, which is phenyl substituted with

7. Q is a cyclic amine represented by formula IIa above, wherein p 1 and p 2 are both 1; X is hydrogen, hydroxyl, alkoxy, or halogen; Y is cyano, C 1 ~C 6 Alkyl, C 1 ~C 6 Alkoxy-C 1 ~C 6 Alkyl, C 1 ~C 6 Alkylsulfanyl-C 1 ~C 6 Alkyl, C 1 ~C 6 Alkylsulfinyl-C 1 ~C 6 Alkyl, C 1 ~C 6 Alkylsulfonyl-C 1 ~C 6 Alkyl, R a R b N.C. (O), R c C(O)NR d , R e SO 2 N.R. f , R g O-N=CR h , a 4-6 membered non-aromatic heterocyclic ring system in which 1 or 2 carbons are independently replaced by nitrogen, oxygen, sulfur, or sulfonyl, phenyl, 1 to 3 substituents R 8 phenyl, 5- or 6-membered monocyclic heteroaryl, or 1 to 3 substituents R 9 is a 5- or 6-membered monocyclic heteroaryl substituted with a , R b , R c , R d , R e , R f , R g , R h , R 8 and R 9 The compound according to any one of claims 1 to 6, wherein is as defined in claim 1.

8. Q is a cyclic amine represented by formula IIb above, where q 1 and q 2 are both 1; A is cyano, C 1 ~C 6 Cyanoalkyl, C 2 ~C 6 Cyanoalkenyl, C 3 ~C 6 Cyanocycloalkyl, C 1 ~C 6 Haloalkyl, C 1 ~C 6 Haloalkenyl, C 3 ~C 6 Halocycloalkyl, C 1 ~C 6 Alkoxycarbonyl, C 2 ~C 6 Alkenyloxycarbonyl, C 2 ~C 6 Alkynyloxycarbonyl, R i SO 2 , R j R k NSO 2 , phenyl, 1 to 3 substituents R 10 phenyl, heteroaryl (either 5- or 6-membered monocyclic or 8-, 9- or 10-membered bicyclic), or one to three substituents R 11 heteroaryl (either 5- or 6-membered monocyclic or 8-, 9- or 10-membered bicyclic) substituted with i , R j , R k , R 10 and R 11 The compound according to any one of claims 1 to 6, wherein is as defined in claim 1.

9. A composition comprising a compound according to any one of claims 1 to 8, one or more auxiliaries and diluents, and optionally one other active ingredient.

10. (i) a method, other than medical treatment for humans, for combating and controlling insects, acarids, nematodes or molluscs, which comprises applying to the pest, the pest's habitat, or to plants susceptible to attack by the pest, an insecticidally, acaricidally, nematicidally or molluscicidally effective amount of a compound according to any one of claims 1 to 8 or a composition according to claim 9; or (ii) a method for the protection of plant propagation material from attack by insects, acarids, nematodes or mollusks, excluding medical intervention in humans, which comprises treating said propagation material or the locus in which said propagation material is planted with an effective amount of a compound according to any one of claims 1 to 8 or a composition according to claim 9; or (iii) A method for controlling parasites in or on an animal in need thereof, excluding medical treatment for humans, comprising administering an effective amount of a compound according to any one of claims 1 to 8 or a composition according to claim 9.

11. 10. Plant propagation material, such as seeds, comprising, treated with or having attached thereto a compound according to any one of claims 1 to 8 or a composition according to claim 9.

12. Compound of formula III-a 【Chemistry 3】 (In the formula, R 1 , R 3 and R 5 is defined in claim 1); Compound of formula Va 【Chemistry 4】 (In the formula, R 1 , R 3 and R 5 is defined in claim 1 ; or Compound of formula VI-a 【Chemistry 5】 (In the formula, R 1 , R 3 and R 5 is defined in claim 1, and R x is selected from methyl, ethyl, propyl, iso-propyl, butyl, iso-butyl and tert-butyl).

13. Compound of formula VII-a 【Chemistry 6】 (In the formula, R 1 and R 3 is defined in claim 1, and R x is selected from methyl, ethyl, propyl, iso-propyl, butyl, iso-butyl and tert-butyl; Compound of formula IX-a 【Chemistry 7】 (In the formula, R 1 and R 3 is defined in claim 1, and R x is selected from methyl, ethyl, propyl, iso-propyl, butyl, iso-butyl and tert-butyl, and LG 2 is chloro); or Compound XIV-a 【Chemistry 8】 (In the formula, R 1 is defined in claim 1, and R 3 is methoxymethyl).

14. Compound of formula XI-a 【Chemistry 9】 (In the formula, R 1 , R 3 , X and Y are defined in claim 1; Compound XI-b 【Chemistry 10】 (In the formula, R 1 , R 3 and A is defined in claim 1; Compound XII-a 【Chemistry 11】 (In the formula, R 1 , R 3 , X and Y are defined in claim 1, and LG 2 is chloro, bromo or fluoro; or Compound XII-b 【Chemistry 12】 (In the formula, R 1 , R 3 and A are defined in claim 1, and LG 2 is chloro, bromo or fluoro).

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