Protease inhibitors for the treatment of coronavirus infections

Abstract

The present application relates to compounds of formula (I) and (III), their pharma- ceutically acceptable salts, and pharmaceutical compositions thereof, which inhibit the main protease (M) of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). pro ), which are useful in treating or preventing COVID-19 in a subject. [Formula 1] TIFF2024526063000624.tif81157

Description

[Technical Field]

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS This application claims the benefit of priority to U.S. Provisional Patent Application No. 63 / 209,862, filed July 11, 2021, and U.S. Provisional Patent Application No. 63 / 266,234, filed December 30, 2021, the contents of which are incorporated by reference in their entireties. [Background technology]

[0002] In early December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified as the cause of a surge in severe pneumonia-like symptoms, designated COVID-19. Since then, SARS-CoV-2 has been legitimately recognized as a pandemic by the World Health Organization (WHO). As of May 7, 2021, SARS-CoV-2 has spread worldwide, causing 155 million confirmed infections in 223 different countries and more than 3.25 million reported deaths. The development of several effective anti-SARS-CoV-2 vaccines could contribute to containing the pandemic. However, the emergence of SARS-CoV-2 strains with escape mutations that reduce the effectiveness of some vaccines and the overall limited global supply of COVID-19 vaccines necessitate ongoing efforts to identify therapeutic interventions. Despite significant efforts by the research community, antiviral treatment options for COVID-19 remain limited. These include corticosteroids such as dexamethasone and the intravenous antiviral drug remdesivir for the treatment of patients with severe or critical COVID-19.

[0003] Remdesivir, a nucleotide analogue prodrug and RNA-dependent RNA polymerase (RdRp) inhibitor with broad antiviral activity, demonstrated positive clinical endpoints in a phase III adaptive COVID-19 treatment trial (reducing the median time to recovery from 15 days to 11 days), leading to its emergency use authorization by the US Food and Drug Administration for the treatment of hospitalized COVID-19 patients. However, recently, remdesivir, when combined with hydroxychloroquine, lopinavir, and interferon therapy, did not reduce mortality in hospitalized COVID-19 patients in the large, multicenter WHO SOLIDARITY trial. 9 Remdesivir's modest efficacy and intravenous delivery should result in greater clinical improvement and facilitate the discovery of new or complementary therapies that can be administered outside the hospital (i.e., orally).

[0004] Besides RdRp, other high-value drug targets have been identified in SARS-CoV-2. This virus, which belongs to the Betacoronavirus genus, encodes two largely overlapping polyprotein precursors (pp1a and pp1ab), four structural proteins (spike, envelope, membrane, and nucleocapsid), and several accessory proteins. Successful viral replication requires the cleavage of the two polyproteins (pp1a / pp1ab) into individual nonstructural proteins (Y. Chen et al. J. Med. Virol. 2020;92(10):2249.). Two viral proteases are essential: the polyprotein:major protease (M pro or 3CL proteases) and papain-like proteases (Hilgenfeld R. From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design. FEBS J. 2014;281(18):4085-96). Importantly, M procleaves polypeptides following the glutamine residue at the P1 position of the substrate, a unique activity not observed in other human proteases, suggesting that this viral protease can be specifically and selectively inhibited by small molecule inhibitors (Zhang L et al. α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment. J Med Chem. 2020;63(9):4562-4578). [Prior art documents] [Non-patent literature]

[0005] [Non-Patent Document 1] Y. Chen et al. J. Med. Virol. 2020;92(10):2249 [Non-patent document 2] Hilgenfeld R. From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design. FEBS J. 2014;281(18):4085-96 [Non-patent document 3] Zhang L et al. α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment. J Med Chem. 2020;63(9):4562-4578 Summary of the Invention

[0006] M proExamination of the active site of SARS-CoV-2 revealed four sites (S1′, S1, S2, and S4), which can accommodate four corresponding fragments of the substrate (P1′, P1, P2, and P3, respectively). Because polypeptides are natural substrates, peptidomimetic inhibitors are a rational choice for small molecules with high affinity for the protease. The affinity of peptidomimetic inhibitors can be further enhanced by introducing a warhead into P1 to form a covalent bond with the catalytic site Cys145, a residue essential for antiviral activity (Dai W et al. Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease. Science. 2020;368(6497):1331-1335). Furthermore, it is well established that glutamine derivatives (γ-lactams) are highly preferred for occupying the S1 site of cysteine ​​proteases, which not only mimic the natural P1 glutamine of the substrate but also enhance the activity of the inhibitor (Dragovich PS et al. Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 4. Incorporation of P1 lactam moieties as L-glutamine replacements. J Med Chem. 1999;42(7):1213-24). Furthermore, bicycloproline moieties, (1R,2S,5S)-6,6-dimethyl-3-aza-bicyclo[3.1.0]hexane-2-formamide (P2 of boceprevir) or (1S,3aR,6aS)-octahydrocyclopenta[c]pyrrole-1-formamide (P2 of telaprevir), have been used as the P2 fragments, as well as M proIt favorably occupies the S2 pocket of the P3 fragment (Qiao J et al. SARS-CoV-2 Mpro inhibitors with antiviral activity in a transgenic mouse model. Science. 2021;371(6536):1374-1378). As previously reported, rigid, hydrophobic bicycloprolines can increase the exposure of orally administered compounds (Yip Y et al. Discovery of a novel bicycloproline P2-bearing peptidyl alpha-ketoamide LY514962 as an HCV protease inhibitor. Bioorg Med Chem Lett. 2004;14(1):251-6). Therefore, modifications to the P3 fragment and specific warhead-representing molecules are important for conferring favorable bioactivity and pharmacokinetic properties to optimal drug candidates.

[0007] Finally, a compound designated PF-00835231 is a potent COVID-2M pro PF-00835231 is a protease inhibitor that recently advanced into clinical trials for COVID-2 via IV infusion of its phosphate prodrug. The corresponding methyl ether of PF-00835231 is 3-5 times less active in cellular and enzymatic assays (Hoffman, RL et al., J. Med. Chem. (2020) 63, 12725-12747).

[0008] The present disclosure provides a method for the preparation of COVID-2M as a compound of formula (I) or a pharmaceutically acceptable salt thereof. pro The present invention provides surprisingly potent inhibitors of [ka]

[0009] During the ceremony, R 1 teeth, C1-C6-Alkyl, C3-C 10 -Cycloalkyl, C6-C 10-aryl, and 5-10 membered heteroaryl (1-4 heteroaryl ring members independently selected from N, O and S), wherein any alkyl, cycloalkyl, aryl and heteroaryl are mono- to perhalogenated, and optionally any alkyl, cycloalkyl, aryl and heteroaryl are mono- to perfluorinated, or any cycloalkyl, aryl and heteroaryl are substituted with 1-3 C1-C6-haloalkyl; and P(O)(R 1a )2[each R 1a is C6-C 10 -aryl, 5-10 membered heteroaryl (wherein 1-4 heteroaryl ring members are independently selected from N, O and S), and C1-C6-alkyl optionally interrupted by one or more heteroatoms selected from -NH-, O and S. selected from the group consisting of: R 2 teeth, [ka]

[0010] , C1-C6-alkyl, -(C1-C6-alkyl)(C3-C 10 -cycloalkyl), -(C1-C6-alkyl)(3-6 membered heterocycloalkyl) (1-4 ring members independently selected from C(O), N, O and S), -(C1-C6-alkyl)(5-10 membered heteroaryl) (1-4 heteroaryl ring members independently selected from N, O and S), -(C1-C6-alkyl)NR 6 R 7 , C1-C6-alkyl (-NH-, O and S(O) 0-2 -(C1-C6-alkyl)N(H)CN(H)NH2, and -(C1-C6-alkyl)C(O)NR 6 R 7 is selected from the group consisting of R 6 and R 7 are independently selected from H and C1-C6-alkyl; R 3a , R 3b and R 4 In each case, H, C1-C8-alkyl, C2-C8-alkenyl, C3-C 10 -cycloalkyl, -(C1-C6-alkyl)(C3-C 10 -cycloalkyl), -(C1-C6-alkyl)(C6-C 10 -aryl), -(C-C-alkyl)(3- to 6-membered heterocycloalkyl) (1-4 ring members independently selected from N, O, and S), and -(C-C-alkyl)(5- to 10-membered heteroaryl) (1-4 heteroaryl ring members independently selected from N, O, and S); R 3a , R 3b and R 4 is halo, OH, NH, C-C-alkyl optionally substituted with NH, C-C-haloalkyl, C-C-alkoxy, C-C-cycloalkyl (optionally substituted with 1 to 3 substituents independently selected from halo and NH), CN, and CONR 6 R 7 optionally and independently substituted with 1 to 5 substituents independently selected from the group consisting of: or R 3a and R 4 , R 3b and R 4 , or R 3a and R 3b together with the atoms to which they are attached form a monocyclic or bicyclic ring having 3 to 10 ring members selected from C, N, O and S, which, when bicyclic, may be fused, bridged or spiro-fused, said monocyclic or bicyclic ring being optionally and independently substituted with 1 to 3 substituents selected from halo, OH, C2-C6-alkenyl, C1-C6-haloalkyl, C1-C6-alkoxy, C3-C8-cycloalkyl (optionally and independently substituted with 1 to 3 substituents selected from halo and NH2), C6-C 10-aryl, C1-C6-alkyl optionally substituted with NH2, (C1-C6-alkyl)-(C3-C8-cycloalkyl), 3- to 6-membered heterocycloalkyl (1-4 ring members independently selected from N, O and S), CN, and CONR 6 R 7 may be substituted with; A is a bond or a moiety of formula (II): [ka]

[0011] and; R 8 and R 8a is H, C1-C8-alkyl, C3-C 10 -Cycloalkyl, C6-C 10 -aryl, 3-6 membered heterocycloalkyl (1-4 ring members independently selected from N, O and S), 5-10 membered heteroaryl (1-4 heteroaryl ring members independently selected from N, O and S), -(C1-C6-alkyl)(C3-C 10 -cycloalkyl), -(C1-C6-alkyl)(C6-C 10 -aryl), -(C1-C6-alkyl)(3- to 6-membered heterocycloalkyl) (1-4 ring members independently selected from N, O, and S), and -(C1-C6-alkyl)(5- to 10-membered heteroaryl) (1-4 heteroaryl ring members independently selected from N, O, and S); R 8 and R 8a is halo, OH, C1-C6-alkoxy, C3-C8-cycloalkyl (optionally substituted with 1 to 3 substituents independently selected from halo and NH2), NH2, C1-C6-alkyl optionally substituted with NH2, CN, and CONR 6 R 7 and optionally and independently substituted with 1 to 5 substituents independently selected from the group consisting of: or R 4 and R 8 or R 8 and R 8atogether with the atoms to which they are attached form a monocyclic or bicyclic ring having 3 to 10 ring members selected from C, N, O and S, which, when bicyclic, may be fused, bridged or spiro-fused, said monocyclic or bicyclic ring being selected from halo, OH, C-C-haloalkyl, C-C-alkoxy, C-C-cycloalkyl (optionally and independently substituted with 1 to 3 substituents selected from halo and NH), C-C-alkyl optionally substituted with NH, 3- to 6-membered heterocycloalkyl (1 to 4 ring members independently selected from N, O and S), CN, CONR 6 R 7 may be substituted with; R 5 is C1-C 20 -alkyl (optionally interrupted by one or more heteroatoms selected from -NH-, O and S), C2-C6-alkenyl, C6-C 10 -aryl, 5-10 membered heteroaryl (1-4 heteroaryl ring members independently selected from N, O and S), -(C-C alkyl)(C-C 10 -aryl), -O-(C1-C6-alkyl)(C6-C 10 -aryl), -O-(C3-C8-cycloalkyl), -O-(C1-C6-alkyl)(C3-C8-cycloalkyl), -(C1-C6-alkyl)-O-(C6-C 10 -aryl), -(C1-C6-alkyl)-NH-(C6-C 10 -aryl), -(C1-C6-alkyl)-NHC(O)-(C6-C 10 -aryl), -(C2-C6-alkenyl)(C6-C 10 -aryl), -(C1-C6-alkyl)(3-6 membered heterocyclic alkyl) (1-4 ring members are N, O and S(O) 0-2independently selected from), C3-C8-cycloalkyl, -(C1-C6-alkyl)-NH-(C3-C8-cycloalkyl), -(C1-C6-alkyl)-(C3-C8-cycloalkyl), 3- to 14-membered heterocycloalkyl (1-4 ring members independently selected from N, O and S), -O-(3- to 8-membered heterocycloalkyl (1-4 ring members independently selected from N, O and S)), -(C1-C6-alkyl)-(5- to 10-membered heteroaryl (1-4 heteroaryl ring members independently selected from N, O and S)), -C(O)-(C1-C6-alkyl), -C(O)(C6-C 10 -aryl), -(C1-C6-alkyl)-NH-(5-10 membered heteroaryl (1-4 heteroaryl ring members independently selected from N, O and S)), -CHN(OH), -(C1-C6-alkyl)-NH-S(O)2-NR 9 R 10 ), -O-(C2-C6-alkenyl)-(C6-C 10 -aryl), -C(O)OR 9 , -(C1-C6-alkyl)-C(O)OR 9 , -(C1-C6-alkyl)-S(O)2-NH2, and -NH-C6-C 10 -aryl, R 5 is halo, C1-C6-alkyl, C1-C6-haloalkyl, oxo, -C1-C6-alkyl-NH2, -C6-C 10 -aryl (optionally substituted with 1 to 3 halo), -(C1-C6-alkyl)(C6-C 10 -aryl), 5-10 membered heteroaryl (1-4 heteroaryl ring members independently selected from N, O and S), CN, OCF3, COR 9 , -OC(O)R 9 ,CONR 9 R 10 , -OCONR 9 R 10 , N.R. 9 R 10 , -NR 9 C(O)NR 9 R 10 , -NR 9 C(O)OR 10, -NR 9 S(O)2R 10 , OR 9 , S.R. 9 , SO2R 9 , -N(H)C(O)(3-6 membered heterocycloalkyl), -N=O, and -N(H)C(O)CF3, and two of the substituents together with the carbon atoms to which they are attached may form a monocyclic or bicyclic ring having 3-10 ring members selected from C, N, O, and S; R 9 and R 10 is H, C1-C6-alkyl, C3-C8-cycloalkyl, C6-C 10 -aryl, and -(C1-C6-alkyl)(C6-C 10 -aryl); or R 5 teeth, [ka]

[0012] and R 11 and R 12 is H, C1-C8 alkyl, C3-C8 cycloalkyl, -(C1-C6 alkyl)-C3-C8 cycloalkyl, -(C3-C8 cycloalkyl)(C6-C 10 -aryl), -(C3-C8-cycloalkyl)-(C1-C6-alkyl), C6-C 10 -aryl, -(C1-C6-alkyl)(C6-C 10 -aryl), 5-10 membered heteroaryl (1-4 heteroaryl ring members independently selected from N, O, and S), -(C1-C6-alkyl) (5-10 membered heteroaryl (1-4 heteroaryl ring members independently selected from N, O, and S)), 3-6 membered heterocycloalkyl (1-4 ring members independently selected from N, O, and S(O) 0-2 -(C-C alkyl) (3-8 membered heterocycloalkyl (1-4 ring members independently selected from N, O and S)), and -S(O)-N(H)(C-C 10-aryl), R 11 and R 12 is halo, OH, NH, C-C-haloalkyl, C-C-alkyl (optionally and independently substituted with 1 to 3 substituents selected from halo and NH or optionally interrupted by one or more heteroatoms selected from -NH-, O and S), C-C-alkoxy (optionally substituted with 1 to 3 halo), C-C-cycloalkyl (optionally and independently substituted with 1 to 3 substituents selected from halo and NH), CN, -(C-C-alkyl)(C-C 10 -aryl), and CONR 6 R 7 and optionally substituted with 1 to 3 substituents independently selected from the group consisting of: or R 11 and R 12 together with the nitrogen atom to which they are attached form a monocyclic or bicyclic ring having 4 to 10 ring members selected from C, N, O and S, which, if bicyclic, may be fused, bridged or spiro-fused; The monocyclic or bicyclic ring may be selected from halo, OH, C-C-haloalkyl, C(O)R 9 , C1-C6-alkoxy, C3-C8-cycloalkyl (optionally and independently substituted with 1 to 3 substituents selected from halo and NH2), C1-C6-alkyl optionally substituted with NH2, 3- to 6-membered heterocycloalkyl (1 to 4 ring members independently selected from N, O and S), CN, and CONR 6 R 7 It may be substituted with 1 to 3 substituents selected from the following.

[0013] In some embodiments, in Formula (I), R 1 teeth, C1-C6-Alkyl, C3-C 10 -Cycloalkyl, C6-C 10-aryl, and 5-10 membered heteroaryl (1-4 heteroaryl ring members independently selected from N, O, and S), wherein any alkyl, cycloalkyl, aryl, and heteroaryl are mono- or perfluorinated; and P(O)(R 1a )2[each R 1a is C6-C 10 -aryl, 5-10 membered heteroaryl (wherein 1-4 heteroaryl ring members are independently selected from N, O and S), and C1-C6-alkyl optionally interrupted by one or more heteroatoms selected from -NH-, O and S. is selected from the group consisting of:

[0014] In some embodiments, R 2 teeth, [ka]

[0015] , -(C1-C6-alkyl)(C3-C 10 -cycloalkyl), and -(C1-C6-alkyl)N(H)CN(H)NH2, and -(C1-C6-alkyl)C(O)NR 6 R 7 (R 6 and R 7 are independently selected from H and C1-C6-alkyl.

[0016] In some embodiments, R 3a , R 3b and R 4 In each case, H, C1-C8-alkyl, C2-C8-alkenyl, C3-C 10 -cycloalkyl, -(C1-C6-alkyl)(C3-C 10 -cycloalkyl), -(C1-C6-alkyl)(C6-C 10-aryl), -(C1-C6-alkyl)(3-6 membered heterocycloalkyl) (1-4 ring members independently selected from N, O and S), and -(C1-C6-alkyl)(5-10 membered heteroaryl) (1-4 heteroaryl ring members independently selected from N, O and S).

[0017] In various embodiments, R 3a , R 3b and R 4 is halo, OH, NH, C-C-alkyl optionally substituted with NH, C-C-haloalkyl, C-C-alkoxy, C-C-cycloalkyl (optionally substituted with 1 to 3 substituents independently selected from halo and NH), CN, CONR 6 R 7 is optionally and independently substituted with 1 to 5 substituents independently selected from the group consisting of:

[0018] In some embodiments, R 3a and R 4 , R 3b and R 4 , or R 3a and R 3b together with the atoms to which they are attached form a monocyclic or bicyclic ring having 3 to 10 ring members selected from C, N, O and S, which, when bicyclic, may be fused, bridged or spiro-fused, said monocyclic or bicyclic ring being selected from halo, OH, C2-C6-alkenyl, C1-C6-haloalkyl, C1-C6-alkoxy, C3-C8-cycloalkyl (optionally and independently substituted with 1 to 3 substituents selected from halo and NH2), C1-C6-alkyl optionally substituted with NH2, 3- to 6-membered heterocycloalkyl (1 to 4 ring members independently selected from N, O and S), CN, and CONR 6 R 7 may be substituted with.

[0019] In some embodiments, A is a bond or a moiety of formula (II): [ka]

[0020] and; R 8 and R 8a is H, C1-C8-alkyl, C3-C 10 -Cycloalkyl, C6-C 10 -aryl, 3-6 membered heterocycloalkyl (1-4 ring members independently selected from N, O and S), 5-10 membered heteroaryl (1-4 heteroaryl ring members independently selected from N, O and S), -(C1-C6-alkyl)(C3-C 10 -cycloalkyl), -(C1-C6-alkyl)(C6-C 10 -aryl), -(C1-C6-alkyl)(3-6 membered heterocycloalkyl) (1-4 ring members independently selected from N, O and S), and -(C1-C6-alkyl)(5-10 membered heteroaryl) (1-4 heteroaryl ring members independently selected from N, O and S).

[0021] In some embodiments, R 8 and R 8a is halo, OH, C1-C6-alkoxy, C3-C8-cycloalkyl (optionally substituted with 1 to 3 substituents independently selected from halo and NH2), NH2, C1-C6-alkyl optionally substituted with NH2, CN, and CONR 6 R 7 is optionally and independently substituted with 1 to 5 substituents independently selected from the group consisting of:

[0022] In embodiments, R 4 and R 8 or R 8 and R 8atogether with the atoms to which they are attached form a monocyclic or bicyclic ring having 3 to 10 ring members selected from C, N, O and S, which, when bicyclic, may be fused, bridged or spiro-fused, said monocyclic or bicyclic ring being selected from halo, OH, C-C-haloalkyl, C-C-alkoxy, C-C-cycloalkyl (optionally and independently substituted with 1 to 3 substituents selected from halo and NH), C-C-alkyl optionally substituted with NH, 3- to 6-membered heterocycloalkyl (1 to 4 ring members independently selected from N, O and S), CN, and CONR 6 R 7 may be substituted with.

[0023] In some embodiments, R 5 is C1-C 20 -alkyl, such as C1-C6-alkyl (optionally interrupted by one or more heteroatoms selected from -NH-, O and S), C6-C 10 -aryl, 5-10 membered heteroaryl (1-4 heteroaryl ring members independently selected from N, O and S), -(C-C alkyl)(C-C 10 -aryl), -O-(C1-C6-alkyl)(C6-C 10 -aryl), -O-(C3-C8-cycloalkyl), -O-(C1-C6-alkyl)(C3-C8-cycloalkyl), -(C1-C6-alkyl)-O-(C6-C 10 -aryl), -(C1-C6-alkyl)-NH-(C6-C 10 -aryl), -(C1-C6-alkyl)-NHC(O)-(C6-C 10 -aryl), -(C2-C6-alkenyl)(C6-C 10 -aryl), -(C1-C6-alkyl)(3-6 membered heterocyclic alkyl) (1-4 ring members are N, O and S(O) 0-2C-C-cycloalkyl, 3- to 14-membered, for example 3- to 6-membered, heterocycloalkyl (1-4 ring members independently selected from N, O, and S), —O-(3- to 6-membered heterocycloalkyl (1-4 ring members independently selected from N, O, and S)), —(C-C-alkyl)-(5- to 10-membered heteroaryl (1-4 heteroaryl ring members independently selected from N, O, and S)), and —(C-C-alkyl)-NH-(5- to 10-membered heteroaryl (1-4 heteroaryl ring members independently selected from N, O, and S)).

[0024] In various embodiments, R 5 is halo, C1-C6-alkyl, C1-C6-haloalkyl, -C1-C6-alkyl-NH2, -C6-C 10 -aryl, -(C1-C6-alkyl)(C6-C 10 -aryl), CN, COR 9 , -OC(O)R 9 ,CONR 9 R 10 , -OCONR 9 R 10 , N.R. 9 R 10 , -NR 9 C(O)NR 9 R 10 , -NR 9 C(O)OR 10 , OR 9 , S.R. 9 , SO2R 9 , —N(H)C(O)(3- to 6-membered heterocycloalkyl), and —N(H)C(O)CF3, and two of the substituents together with the carbon atoms to which they are attached may form a monocyclic or bicyclic ring having 3 to 10 ring members selected from C, N, O and S.

[0025] R 9 and R 10 is H, C1-C6-alkyl, C3-C8-cycloalkyl, C6-C 10 -aryl, and -(C1-C6-alkyl)(C6-C 10-aryl).

[0026] In some embodiments, R 5 teeth, [ka]

[0027] and R 11 and R 12 is H, C1-C8 alkyl, C3-C8 cycloalkyl, -(C1-C6 alkyl)-C3-C8 cycloalkyl, C6-C 10 -aryl, -(C1-C6-alkyl)(C6-C 10 -aryl), 5-10 membered heteroaryl (1-4 heteroaryl ring members independently selected from N, O, and S), -(C-C-alkyl) (5-10 membered heteroaryl (1-4 heteroaryl ring members independently selected from N, O, and S)), 3-6 membered heterocycloalkyl (1-4 ring members independently selected from N, O, and S), -(C-C-alkyl) (3-6 membered heterocycloalkyl (1-4 ring members independently selected from N, O, and S)), and -S(O)-N(H)(C-C 10 -aryl).

[0028] R 11 and R 12 is halo, OH, NH, C-C-alkyl (optionally and independently substituted with 1 to 3 substituents selected from halo and NH), C-C-alkoxy, C-C-cycloalkyl (optionally and independently substituted with 1 to 3 substituents selected from halo and NH), CN, —(C-C-alkyl)(C-C 10 -aryl), and CONR 6 R 7 It may be substituted with 1 to 3 substituents independently selected from the group consisting of:

[0029] In some embodiments, R 11 and R 12together with the nitrogen atom to which they are attached form a monocyclic or bicyclic ring having 4 to 10 ring members selected from C, N, O and S, which, when bicyclic, may be fused, bridged or spiro-fused. The monocyclic or bicyclic ring may be selected from halo, OH, C-C-haloalkyl, C-C-alkoxy, C-C-cycloalkyl (optionally and independently substituted with 1 to 3 substituents selected from halo and NH), C-C-alkyl optionally substituted with NH, 3- to 6-membered heterocycloalkyl (1 to 4 ring members independently selected from N, O and S), CN, and CONR 6 R 7 It may be substituted with 1 to 3 substituents selected from the following.

[0030] The present disclosure also provides, in embodiments, a pharmaceutical composition comprising a compound described herein or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.

[0031] In another embodiment, the present disclosure provides a method for detecting the major protease (M) of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). pro The present invention provides a method for inhibiting M pro with a compound described herein or a pharmaceutically acceptable compound thereof.

[0032] Another embodiment is a method of treating COVID-19 in a subject suffering from COVID-19 or a method of preventing COVID-19 in a subject. pro with a compound described herein or a pharmaceutically acceptable compound thereof.

[0033] In one embodiment, the present disclosure provides a method for detecting the major protease (M) of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in a subject. pro Also provided are compounds described herein, or pharmaceutically acceptable salts thereof, for inhibiting the

[0034] In another embodiment, the present disclosure provides a compound as described herein, or a pharmaceutically acceptable salt thereof, for treating COVID-19 in a subject suffering from COVID-19 or for preventing COVID-19 in a subject. DETAILED DESCRIPTION OF THE INVENTION

[0035] The compounds of the present disclosure are pro are potent inhibitors of β-lactamase, exhibit remarkable metabolic stability, and are useful for oral administration to patients for the treatment of and prophylaxis against COVID-19. pro Limited evidence to date on the inhibitor PF-00835231 indicates that its methyl ether is 3-5 times less active in cellular and enzymatic assays (RL Hoffman, 2020). In contrast, compounds of formula (I) of the present disclosure, including fluorinated phenyl ethers and fluorinated alkyl ethers, exhibit antiviral activity, including high cellular potency (EC of less than about 5 nM), as demonstrated by the Examples herein. 50 ) shows an unexpectedly dramatic improvement.

[0036] definition "Alkyl" refers to a straight or branched chain hydrocarbyl containing 1 to about 20 carbon atoms. For example, an alkyl can have 1 to 10 carbon atoms or 1 to 6 carbon atoms. Exemplary alkyls include straight chain alkyl groups such as methyl, ethyl, propyl, butyl, pentyl, hexyl, heptyl, octyl, nonyl, decyl, undecyl, dodecyl, and the like, and also include branched chain isomers of straight chain alkyl groups, such as -CH(CH3)2, -CH(CH3)(CH2CH3), -CH(CH2CH3)2, -C(CH3)3, -C(CH2CH3)3, -CH2CH(CH3)2, -CH2CH(CH3)(CH2CH3), -CH2CH(CH2CH3 )2, -CH2C(CH3)3, -CH2C(CH2CH3)3, -CH(CH3)CH(CH3)(CH2CH3), -CH2CH2CH(CH3)2, -CH2CH2CH(CH3)(CH2CH3), -CH2CH2CH(CH2CH3)2, -CH2CH2C(CH3)3, -CH2CH2C(CH2CH3)3, -CH(CH3)CH2CH(CH3)2, -CH(CH3)CH(CH3)CH(CH3)2. Thus, alkyl groups include primary alkyl groups, secondary alkyl groups, and tertiary alkyl groups. Alkyl groups can be unsubstituted or substituted with one or more substituents as described herein.

[0037] The terms "halogen", "halide", and "halo" refer to F or fluoro, Cl or chloro, Br or bromo, or I or iodo, respectively.

[0038] The term "alkenyl" refers to a straight-chain or branched hydrocarbyl group containing 1 to 3, 1 to 2, or 2 to about 20 carbon atoms having at least one carbon-carbon double bond. Alkenyl groups can be unsubstituted or optionally substituted with one or more substituents as described herein.

[0039] "Alkyne" or "alkynyl" refers to a straight-chain or branched unsaturated hydrocarbon having the specified number of carbon atoms and at least one triple bond. Examples of (C2-C8)alkynyl groups include, but are not limited to, acetylene, propyne, 1-butyne, 2-butyne, 1-pentyne, 2-pentyne, 1-hexyne, 2-hexyne, 3-hexyne, 1-heptyne, 2-heptyne, 3-heptyne, 1-octyne, 2-octyne, 3-octyne, and 4-octyne. Alkynyl groups can be unsubstituted or substituted with one or more substituents as described herein.

[0040] The term "alkoxy" or "alkoxyl" refers to an O-alkyl group having the indicated number of carbon atoms. For example, (C1-C6)-alkoxy groups include -O-methyl, -O-ethyl, -O-propyl, -O-isopropyl, -O-butyl, -O-sec-butyl, -O-tert-butyl, -O-pentyl, -O-isopentyl, -O-neopentyl, O-hexyl, -O-isohexyl, and -O-neohexyl.

[0041] The term "cycloalkyl" refers to a saturated monocyclic, bicyclic, tricyclic, or polycyclic 3- to 14-membered ring system, such as C3-C8-cycloalkyl. The cycloalkyl can be attached via any atom. Representative examples of cycloalkyl include, but are not limited to, cyclopropyl, cyclobutyl, cyclopentyl, and cyclohexyl. Polycyclic cycloalkyls include rings that can be fused, bridged, and / or spiro-fused. Cycloalkyl groups can be unsubstituted or substituted with one or more substituents as described herein.

[0042] "Aryl" when used alone or as part of another term means a carbocyclic aromatic group, whether fused or not, having the specified number of carbon atoms, or up to 14 carbon atoms if no number is specified, e.g., C6-C 10 -aryl or C6-C 14-aryl. Examples of aryl groups include phenyl, naphthyl, biphenyl, phenanthrenyl, naphthacenyl, etc. (See, e.g., Lang's Handbook of Chemistry (Dean, JA, ed.) 13 th ed. Table 7-2

[1985] ). "Aryl" also contemplates aryl rings that are part of a fused polycyclic ring system, such as an aryl fused to a cycloalkyl, as defined herein. An exemplary aryl is phenyl. Aryl groups can be unsubstituted or optionally substituted with one or more substituents as described herein.

[0043] The term "heteroatom" refers to N, O, and S. Compounds of the present disclosure containing N or S atoms can be optionally oxidized to the corresponding N-oxide, sulfoxide, or sulfone compounds.

[0044] "Heteroaryl," alone or in combination with any other moiety described herein, refers to a monocyclic aromatic ring structure containing 5 to 10, e.g., 5 or 6, ring atoms, or a bicyclic aromatic group having 8 to 10 atoms including one or more, e.g., 1 to 4, 1 to 3, or 1 to 2, heteroatoms independently selected from the group consisting of O, S, and N. Heteroaryl is also intended to include oxidized S or N, such as sulfinyl, sulfonyl, and N-oxide of a tertiary ring nitrogen. A carbon or heteroatom is the point of attachment of the heteroaryl ring structure such that a stable compound is produced. Examples of heteroaryl groups include, but are not limited to, pyridinyl, pyridazinyl, pyrazinyl, quinoxalyl, indolizinyl, benzo[b]thienyl, quinazolinyl, purinyl, indolyl, quinolinyl, pyrimidinyl, pyrrolyl, pyrazolyl, oxazolyl, thiazolyl, thienyl, isoxazolyl, oxathiadiazolyl, isothiazolyl, tetrazolyl, imidazolyl, triazolyl, furanyl, benzofuryl, and indolyl. Heteroaryl groups can be unsubstituted or substituted with one or more substituents as described herein.

[0045] A "heterocycloalkyl" is a saturated or partially unsaturated non-aromatic monocyclic, bicyclic, tricyclic, or polycyclic ring system having 3 to 14, e.g., 3 to 6, atoms in which 1 to 3 carbon atoms in the ring are replaced by an O, S, or N heteroatom. Polycyclic heterocycloalkyls include rings that can be fused, bridged, and / or spirofused. Furthermore, heterocycloalkyls are optionally fused to a 5- to 6-membered aryl or heteroaryl and include oxidized S or N, such as sulfinyl, sulfonyl, and N-oxide of a tertiary ring nitrogen. The point of attachment of the heterocycloalkyl ring is at a carbon or heteroatom such that a stable ring is maintained. Examples of heterocycloalkyl groups include, but are not limited to, morpholino, tetrahydrofuranyl, dihydropyridinyl, piperidinyl, pyrrolidinyl, piperazinyl, dihydrobenzofuryl, and dihydroindolyl. Heterocycloalkyl groups can be unsubstituted or optionally substituted with one or more substituents as described herein.

[0046] The terms "nitrile" or "cyano" can be used interchangeably and refer to the group --CN.

[0047] The term "oxo" refers to an =0 atom bonded to an atom that is part of a saturated or unsaturated moiety. Thus, the =0 atom can be bonded to a carbon, sulfur, or nitrogen atom that is part of a cyclic or acyclic moiety.

[0048] "Hydroxyl" or "hydroxy" refers to the group --OH.

[0049] The compounds described herein can exist in various isomeric forms, such as configurational, geometric, and conformational isomers, including cis or trans conformations. The compounds may also exist in one or more tautomeric forms, including both single tautomers and mixtures of tautomers. The term "isomer" is intended to encompass all isomers of the compounds of the present disclosure, including tautomeric forms of the compounds. The compounds of the present disclosure may also exist in open-chain or cyclized forms. In some cases, one or more cyclized forms may arise upon loss of water. The specific composition of the open-chain and cyclized forms may depend on how the compound is isolated, stored, or administered. For example, the compounds may exist primarily in open-chain form under acidic conditions, but may cyclize under neutral conditions. All forms are encompassed by the present disclosure.

[0050] Some compounds described herein may have asymmetric centers and therefore exist in different enantiomeric and diastereomeric forms. The compounds described herein may be in the form of optical isomers or diastereomers. Therefore, the present disclosure encompasses the compounds described herein in the form of optical isomers, diastereomers, and mixtures thereof, such as racemic mixtures, and their use. Optical isomers of the compounds of the present disclosure can be obtained by known techniques, such as asymmetric synthesis, chiral chromatography, simulated moving bed technology, or by chemical separation of stereoisomers using optically active resolving agents.

[0051] Unless otherwise specified, the term "stereoisomer" refers to one stereoisomer of a compound that is substantially free of other stereoisomers of the compound. Thus, a stereoisomerically pure compound having one chiral center is substantially free of the opposite enantiomer of the compound. A stereoisomerically pure compound having two chiral centers is substantially free of other diastereomers of the compound. A typical stereoisomerically pure compound contains greater than about 80% by weight of one stereoisomer of the compound and less than about 20% by weight of the other stereoisomers of the compound, e.g., greater than about 90% by weight of one stereoisomer of the compound and less than about 10% by weight of the other stereoisomers of the compound, or greater than about 95% by weight of one stereoisomer of the compound and less than about 5% by weight of the other stereoisomers of the compound, or greater than about 97% by weight of one stereoisomer of the compound and less than about 3% by weight of the other stereoisomers of the compound, or greater than about 99% by weight of one stereoisomer of the compound and less than about 1% by weight of the other stereoisomers of the compound. The stereoisomers described above can be considered as compositions comprising the two stereoisomers present in the respective weight percentages described herein.

[0052] In the event of a discrepancy between a drawn structure and a name given to that structure, the drawn structure shall prevail. Furthermore, if the stereochemistry of a structure or portion of a structure is not indicated, for example, by a bold or dashed line, the structure or portion of the structure should be interpreted as encompassing all stereoisomers thereof. However, in some cases, when multiple chiral centers are present, the structure and name may be depicted as a single enantiomer to account for the relative stereochemistry. One skilled in the art of organic synthesis will know whether a compound is prepared as a single enantiomer from the method used to prepare the compound.

[0053] As used herein, unless otherwise specified to the contrary, the term "compound" is inclusive in that it encompasses a compound or a pharmaceutically acceptable salt, stereoisomer, and / or tautomer thereof. Thus, for example, a compound of Formula I includes pharmaceutically acceptable salts of tautomers of that compound.

[0054] In the present disclosure, a "pharmaceutically acceptable salt" is a pharmaceutically acceptable organic or inorganic acid or base salt of a compound described herein. Representative pharmaceutically acceptable salts include, for example, alkali metal salts, alkaline earth salts, ammonium salts, water soluble salts, and water insoluble salts, such as acetate, anthonate (4,4-diaminostilbene-2,2-disulfonate), benzenesulfonate, benzoate, bicarbonate, bisulfate, bitartrate, borate, bromide, butyrate, calcium, calcium edetate, camsylate, carbonate, chloride, citrate, clavulanate, dihydrochloride, edetate, edisylate, estrus, esylate, fiunarate, gluceptate, gluconate, glutamate, glycolyl arsanilate, hexafluorophosphate, hexylresorcinate, hydrabamine, hydrobromide, hydrochloride, hydroxynaphthoate, iodide, isothioate, lactate, lactobionate, lanthanide ... Pharmaceutically acceptable salts include phosphate, malate, maleate, mandelate, mesylate, methyl bromide, methyl nitrate, methyl sulfate, mucate, napsylate, nitrate, N-methylglucamine ammonium salt, 3-hydroxy-2-naphthoate, oleate, oxalate, palmitate, pamoate (1,1-methene-bis-2-hydroxy-3-naphthoate, einbonate), pantothenate, phosphate / diphosphate, picrate, polygalacturonate, propionate, p-toluenesulfonate, salicylate, stearate, diacetate, succinate, sulfate, sulfosaliculate, suramate, tannate, tartrate, teoclate, tosylate, triethiodide, and valerate. Pharmaceutically acceptable salts can have multiple charged atoms within their structure. In this case, a pharmaceutically acceptable salt can have multiple counter ions. Hence, a pharmaceutically acceptable salt can have one or more charged atoms and / or one or more counter ions.

[0055] The present disclosure includes all pharmaceutically acceptable isotopically labeled compounds of formula (I) in which one or more atoms are replaced by an atom having the same atomic number but an atomic mass or mass number different from the atomic mass or mass number predominant in nature. Examples of isotopes suitable for inclusion in compounds of the present disclosure include: 2 H and 3 Hydrogen such as H 11 C. 13 C and 14 Carbon, such as C 36 chlorine such as Cl, 18 Fluorine such as F, 123 I and 125 Iodine, such as I 13 N and 15 Nitrogen such as N 15 O. 17 O and 18 Oxygen, such as O 32 Phosphorus, such as P, and 35 Certain isotopically labeled compounds of formula (I), for example those incorporating a radioactive isotope, are useful in drug and / or substrate tissue distribution studies. The radioactive isotope tritium, i.e. 3 H and carbon-14, i.e. 14 C are particularly useful for this purpose in view of their ease of incorporation and ready means of detection. 2 Substitution with heavier isotopes, such as H, may confer certain therapeutic advantages due to increased metabolic stability, increased in vivo half-life or reduced dosage requirements, and therefore may be preferable in some circumstances. 11 C. 18 F, 15 O and 13 Substitution with positron-emitting isotopes, such as N, can be useful in positron emission topography (PET) studies to examine substrate receptor occupancy. Isotopically labeled compounds of formula (I) can generally be prepared by conventional techniques known to those skilled in the art, or by processes similar to those described in the accompanying Examples, substituting appropriate isotopically labeled reagents for previously employed non-labeled reagents.

[0056] The site-specific substitution of atoms with the same atomic number but with atomic mass or mass number different from the predominant atomic mass or mass number in nature can be considered as the substituent of the compounds of the present disclosure.The compound sample with this isotope as a substituent has at least 50% isotope incorporation at the labeled position.The concentration of this isotope, for example, deuterium, can be defined by isotopic enrichment factor.As used herein, the term "isotopic enrichment factor" refers to the ratio between the isotopic abundance and natural abundance of a designated isotope. For example, if a substituent in a compound of the invention is designated as deuterium, such compounds have an isotopic enrichment factor for each designated deuterium atom of at least 3500 (52.5% deuterium incorporation at each designated deuterium atom), at least 4000 (60% deuterium incorporation), at least 4500 (67.5% deuterium incorporation), at least 5000 (75% deuterium incorporation), at least 5500 (82.5% deuterium incorporation), at least 6000 (90% deuterium incorporation), at least 6333.3 (95% deuterium incorporation), at least 6466.7 (97% deuterium incorporation), at least 6600 (99% deuterium incorporation), or at least 6633.3 (99.5% deuterium incorporation).

[0057] Thus, the formulae within this specification can represent only one of the possible tautomers, geometric isomers, or stereoisomers, and it is to be understood that the present invention encompasses any tautomer, geometric isomer, or stereoisomer, and mixtures thereof, and is not limited solely to any one tautomer, geometric isomer, or stereoisomer form employed within the formulae.

[0058] The terms "treat," "treating," and "treatment" refer to the amelioration or eradication of a disease or disease-related symptoms. In various embodiments, these terms refer to the reduction or slowing of the spread, progression, or worsening of a disease resulting from the administration of one or more prophylactic or therapeutic compounds described herein to a patient with such a disease.

[0059] The terms "prevent," "preventing," and "prevention" refer to the prevention of the onset, recurrence, or spread of disease in a patient resulting from the administration of a compound described herein.

[0060] The term "effective amount" refers to an amount of a compound or other active ingredient described herein sufficient to provide a therapeutic or prophylactic benefit in the treatment or prevention of a disease, or to delay or alleviate symptoms associated with a disease. Furthermore, a therapeutically effective amount with respect to a compound described herein means an amount of a therapeutic agent, alone or in combination with other therapies, that provides a therapeutic effect in the treatment or prevention of a disease. When used in connection with a compound described herein, the term can encompass an amount that improves overall therapy, reduces or avoids symptoms or causes of a disease, or enhances the therapeutic efficacy of, or acts synergistically with, another therapeutic agent.

[0061] A "patient" or "subject" includes animals such as humans, cows, horses, sheep, lambs, pigs, chickens, turkeys, quail, cats, dogs, mice, rats, rabbits, or guinea pigs. According to some embodiments, the animals are mammals, such as non-primates and primates (e.g., monkeys and humans). In one embodiment, the patient is a human, such as a human infant, child, adolescent, or adult. In this disclosure, the terms "patient" and "subject" are used interchangeably.

[0062] compound M of this disclosure pro The inhibitor compound, in various embodiments, conforms to formula (I). [ka]

[0063] In the formula, R 1 , R 2 , R 3a , R 3b , R 4 , R 5, and A are defined in the Summary of the Invention above.

[0064] In some embodiments, R 1 is mono- or perfluorinated. In some embodiments, R 1 is mono- or perfluorinated C1-C6-alkyl or C6-C 10 -aryl. The degree of fluorination is limited only by the number of substitutable sites on the alkyl or aryl. Thus, in some embodiments, R 1 is mono- to perfluorinated C1-C6-alkyl, illustrative examples include -CHF2 and -CF3. According to one embodiment, R 1 is —CF3. In other embodiments, R 1 Mono- or perfluorinated C6-C 10 -aryl, such as fluorophenyl, difluorophenyl, trifluorophenyl, tetrafluorophenyl, and pentafluorophenyl. In an exemplary embodiment, R 1 is 2,3,5,6-tetrafluorophenyl: [ka]

[0065] is.

[0066] In an additional embodiment, optionally in combination with any other embodiment, R 2 teeth, [ka]

[0067] Thus, in one embodiment, R 2 teeth [ka]

[0068] In another embodiment, R2 teeth, [ka]

[0069] In an exemplary embodiment, optionally in combination therewith, R 6 is H.

[0070] The present disclosure also provides, according to various embodiments, 3a is H and R 3b optionally substituted C1-C8-alkyl and -(C1-C6-alkyl)(C3-C 10 For example, R 3a is H and R 3b is optionally substituted C1-C8-alkyl. Exemplary C1-C8-alkyl are, among others, those described herein: [ka]

[0071] (isobutyl).

[0072] In yet another embodiment, the moiety in formula (I): [ka]

[0073] is R 3a is H and R 3b and R 4 are selected from those which, together with the atoms to which they are attached, form an optionally substituted 3- to 10-membered monocyclic or bicyclic ring, such as any of the rings described herein. When the ring is bicyclic, it may be fused, bridged, or spiro-fused with another component ring. Thus, in an exemplary embodiment, the moiety: [ka]

[0074] teeth, [ka]

[0075] is selected from the group consisting of:

[0076] In some compounds of formula (I), according to embodiments which may be combined with any other embodiment, A is a bond.

[0077] In one embodiment, R 5 teeth [ka]

[0078] R 11 and R 12 Any and all combinations of are contemplated. In an exemplary embodiment, R 11 is H. In yet further embodiments, R 5 teeth, [ka]

[0079] is selected from the group consisting of:

[0080] In yet other embodiments, R 5 teeth, [ka]

[0081] is selected from the group consisting of:

[0082] In another embodiment, A is a moiety of formula (II): [ka]

[0083] R 8a and R 8 All combinations of are envisioned. Thus, in one embodiment, R 8a is H. Optionally in combination with these embodiments, R 4 and R 8 together with the atoms to which they are attached form an optionally substituted monocyclic or bicyclic ring having 3 to 10 ring members selected from C, N, O and S. When the ring is bicyclic, it may be fused, bridged or spiro-fused. For example, the moiety of formula (II) [ka]

[0084] The present invention includes those selected from the group consisting of:

[0085] In some embodiments, R 1 mono- or perfluorinated C1-C6-alkyl or C6-C 10 -aryl; R 2 but, [ka]

[0086] and; R 3a , R 3b , and R 4 is H, C1-C8-alkyl, -(C1-C6-alkyl)(C3-C 10 -cycloalkyl), -(C1-C6-alkyl)(C6-C 10 -aryl), and -(C-C-alkyl)(3- to 6-membered heterocycloalkyl) (1-4 ring members independently selected from N, O and S); R 3b is optionally substituted with 1 to 5 halo; or R 3a and R 4 , R 3b and R4 , or R 3a and R 3b together with the atoms to which they are attached form a monocyclic or bicyclic ring having 3 to 10 ring members selected from C, N, O and S, which, if bicyclic, may be fused, bridged or spiro-fused, and said monocyclic or bicyclic ring is selected from C-C-alkyl, C-C-haloalkyl, and C-C 10 - optionally substituted with aryl; A is a bond; R 5 But C1-C 20 -alkyl (optionally interrupted by one or more heteroatoms selected from -NH-, O and S), 5-10 membered heteroaryl (1-4 heteroaryl ring members independently selected from N, O and S), -O-(C-C-alkyl) (C-C 10 -aryl), C6-C 10 -aryl, C3-C8-cycloalkyl, 3-14 membered heterocycloalkyl (1-4 ring members independently selected from N, O and S), -(C1-C6-alkyl)(C6-C 10 -aryl), -(C1-C6-alkyl)-(C3-C8-cycloalkyl), -C(O)-(C1-C6-alkyl), and C2-C6-alkenyl; R 5 But, halo, -C6-C 10 -aryl (optionally substituted with 1 to 3 substituents selected from halo), C1-C6-haloalkyl, OR 9 , C1-C6-alkyl, OCF3, -OC(O)R 9 , -OCONR 9 R 10 , and -NR 9 C(O)OR 10 may be substituted with 1 to 3 substituents selected from the group consisting of: R 9 and R 10 is H, C1-C6-alkyl, C3-C8-cycloalkyl, and -(C1-C6-alkyl)(C6-C 10 -aryl); or R 5 but [ka]

[0087] and R 11 and R 12 H, C1-C8 alkyl, C6-C 10 -aryl, and C3-C8-cycloalkyl; R 11 and R 12 halo, C1-C6-haloalkyl, 3-6 membered heterocyclic alkyl (wherein 1-4 ring members are N, O and S(O) 0-2 Disclosed are compounds of formula (I), or a pharmaceutically acceptable salt thereof, optionally substituted with 1 to 3 substituents independently selected from the group consisting of: C1-C6-alkyl (optionally and independently substituted with 1 to 3 substituents selected from halo and NH2 or optionally interrupted by one or more heteroatoms selected from -NH-, O and S), and C1-C6-alkoxy (optionally substituted with 1 to 3 halo).

[0088] In some embodiments, R 1 is trifluoromethyl or tri- or perfluorinated phenyl; R 2 but [ka]

[0089] and; R 3a is H and R 4 is H and R 3b is -CH2-cyclopropyl, -CH2-cyclobutyl, -CH2-cyclohexyl, isobutyl, neopentyl optionally substituted by 1 to 3 fluoro groups, benzyl, or -CH2-tetrahydropyranyl; or R 3a is H and R3b and R 4 together with the atoms to which they are attached form a monocyclic or bicyclic ring having 5 to 8 ring members selected from C and N, which, if bicyclic, is fused or spiro-fused, and said monocyclic or bicyclic ring is optionally substituted with methyl, trifluoromethyl, or phenyl; A is a bond; R 5 Methyl, n-Pr, i-Pr, isobutyl, n-butyl, fully deuterated n-butyl, sec-butyl, iso-pentyl, tert-pentyl, neo-heptyl, 2-methylpentyl, 2,4-dimethylpentyl, 1-methoxy-3-methylbutyl, indolyl, thiazolyl, benzyloxy, 1,3-benzodioxolyl, isoxazolyl, 1,2-benzisoxazolyl, benzoxazolyl, imidazo[1,2-b] selected from the group consisting of pyridazinyl, 1,4-dioxanyl, tetrahydrofuranyl, 2-oxabicyclo[2.1.1]hexanyl, 7-oxabicyclo[2.2.1]heptanyl, benzyl, -(CH2)2-cyclopropyl, cyclopropyl, -CH2-cyclobutyl, cyclobutyl, cyclopentyl, cyclohexyl, -C(O)-(isobutyl), -C(O)-(isopentyl), and 3-methylbut-1-enyl; R 5 is fluoro, chloro, phenyl (which may be substituted with 1 to 3 fluoro), monofluoro-i-Pr, difluoro-i-Pr, trifluoromethyl, methyl, tert-butyl, hydroxy, methoxy, OCF3, -OC(O)NR 9 R 10 , -OC(O)R 9 , and -NR 9 C(O)OR 10 may be substituted with 1 to 3 substituents selected from the group consisting of: R 9 and R 10 are independently selected from the group consisting of H, ethyl, i-Pr, tert-butyl, cyclohexyl, and benzyl; or R 5 but [ka]

[0090] and; R 11 and R 12 are independently selected from the group consisting of H, methyl, tert-butyl, phenyl, cyclopropyl, cyclobutyl, cyclohexyl, and bicyclo[1.1.1]pentanyl; R 11 and R 12 is optionally substituted with 1 to 3 substituents independently selected from the group consisting of fluoro, chloro, monofluoromethyl, trifluoromethyl, tetrahydropyranyl, methyl, and methoxy, or a pharmaceutically acceptable salt thereof.

[0091] In some embodiments, R 1 mono- or perfluorinated C1-C6-alkyl or C6-C 10 -aryl; R 2 but [ka]

[0092] and; R 3a , R 3b , and R 4 are independently selected from H, C1-C8-alkyl; or R 3a and R 4 , R 3b and R 4 , or R 3a and R 3b together with the atoms to which they are attached form a monocyclic or bicyclic ring having 3 to 10 ring members selected from C, N, O and S, which, if bicyclic, is fused or spiro-fused, and said monocyclic or bicyclic ring is optionally substituted by C-C-alkyl or C-C-haloalkyl; A is a bond; R5 But C1-C 20 -alkyl (optionally interrupted by one or more heteroatoms selected from -NH-, O, and S), 5-10 membered heteroaryl (1-4 heteroaryl ring members independently selected from N, O, and S), C3-C8-cycloalkyl, 3-14 membered heterocycloalkyl (1-4 ring members independently selected from N, O, and S), and -(C1-C6-alkyl)(C6-C 10 -aryl); R 5 is optionally substituted with 1 to 3 substituents selected from the group consisting of halo, C1-C6-haloalkyl, and OH; or R 5 but [ka]

[0093] and; R 11 and R 12 H, C1-C8 alkyl, C6-C 10 -aryl, and C3-C8-cycloalkyl; R 11 and R 12 is optionally substituted with 1 to 3 substituents independently selected from the group consisting of halo, C-C-haloalkyl, and C-C-alkyl (optionally and independently substituted with 1 to 3 substituents independently selected from halo and NH, or optionally interrupted by one or more heteroatoms selected from -NH-, O, and S), or a pharmaceutically acceptable salt thereof.

[0094] In some embodiments, R 1 is trifluoromethyl or tetrafluorinated phenyl; R 2 but [ka]

[0095] and; R 3a is H and R 4 is H and R 3b is isobutyl or neopentyl, or R 3a is H and R 3b and R 4 together with the atoms to which they are attached form a monocyclic or bicyclic ring having 5 to 8 ring members selected from C and N, which, if bicyclic, is fused or spiro-fused, and said monocyclic or bicyclic ring is optionally substituted with methyl or trifluoromethyl; A is a bond; R 5 is selected from the group consisting of methyl, iso-pentyl, indolyl, isoxazolyl, tetrahydrofuranyl, 2-oxabicyclo[2.1.1]hexanyl, and benzyl; R 5 is optionally substituted with 1 to 3 substituents selected from the group consisting of fluoro, monofluoro-i-Pr, trifluoromethyl, and hydroxy; or R 5 but [ka]

[0096] and; R 11 and R 12 are independently selected from the group consisting of H, methyl, tert-butyl, phenyl, cyclopropyl, cyclohexyl, and bicyclo[1.1.1]pentanyl; R 11 and R 12 is optionally substituted with 1 to 3 substituents independently selected from the group consisting of fluoro, trifluoromethyl, and methyl, or a pharmaceutically acceptable salt thereof.

[0097] In some embodiments, R 5 teeth, [ka]

[0098] is selected from the group consisting of:

[0099] In some embodiments, R 5 teeth, [ka] TIFF2024526063000033.tif165160

[0100] , Me, Et, i-Pr, n-pentyl, and t-Bu.

[0101] In some embodiments, R 5 teeth, [ka]

[0102] and Me.

[0103] In various embodiments, the present disclosure provides: R 1 is mono- or perfluorinated C1-C6-alkyl; R 2 but [ka]

[0104] and; The part [ka]

[0105] In R 3a is H and R 3b and R 4together with the atoms to which they are attached form an optionally substituted 3- to 10-membered monocyclic or bicyclic ring, which, if bicyclic, may be fused, bridged or spiro-fused; A is a bond; R 5 is C1-C6-alkyl (optionally interrupted by one or more heteroatoms selected from -NH-, O and S), halo, C1-C6-alkyl, C1-C6-haloalkyl, and OR 9 The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, which is optionally substituted with 1 to 3 substituents selected from the group consisting of:

[0106] In another aspect, there is disclosed a compound of formula (III): or a pharmaceutically acceptable salt thereof: [ka]

[0107] During the ceremony, W is —C(O)—NH— or [ka]

[0108] and; Y is R A -C(R 4a )(R 4b )-, R A -C(O)-N(R 4 )-, [ka]

[0109] or (R B )(R 4 )N- and; However, when W is -C(O)-NH-, Y is R A -C(O)-N(R 4 )-rather than; R 1 is C1-C6-alkyl or C6-C10 -aryl, wherein said alkyl and aryl are mono- to perfluorinated; R 2 teeth, [ka]

[0110] and R 6 is H or C1-C6-alkyl; R 3a , R 3b , R 4a , R 4b , and R 4 are each independently selected from H or C1-C8-alkyl, or R 3a and R 4 , R 3b and R 4 , R 3a and R 3b , or R 3a and R 4a together with the atoms to which they are attached form a monocyclic or bicyclic ring having 3 to 10 ring members selected from C, N, O and S, which, if bicyclic, may be fused, bridged or spiro-fused; R A teeth [ka]

[0111] and R 11 is H or C1-C8 alkyl; R 12 is H, C1-C8 alkyl, C6-C 10 -aryl, -(C1-C6-alkyl)(C6-C 10 -aryl); R 11 and R 12 is optionally substituted with 1 to 3 substituents independently selected from the group consisting of halo and C1-C6-haloalkyl; RB is R 13 or -S(O)2-R 13 and R 13 is C6-C 10 -aryl, 5-10 membered heteroaryl (1-4 heteroaryl ring members independently selected from N, O and S), R 13 is optionally substituted with 1 to 3 substituents selected from the group consisting of halo and C1-C6-alkyl.

[0112] In some embodiments, the compound of Formula (III)X or a pharmaceutically acceptable salt thereof has the structure of Formula (III-a), Formula (III-b), Formula (III-c), or Formula (III-d): [ka] TIFF2024526063000043.tif112162

[0113] It has.

[0114] In some embodiments, the compound of Formula (III) or a pharmaceutically acceptable salt thereof has the structure of Formula (III-a): A is -C(O)NH-(C1-C6-alkyl), -C(O)NH-(C6-C 10 -aryl) and -C(O)NH-(C1-C6-alkyl)(C6-C 10 -aryl), and R A may be substituted with 1 to 3 halo.

[0115] In some embodiments, the compound of Formula (III) or a pharmaceutically acceptable salt thereof has the structure of Formula (III-b): A is -C(O)NH-(C6-C 10 -aryl); R A may be substituted with 1 to 3 halo.

[0116] In some embodiments, the compound of Formula (III) or a pharmaceutically acceptable salt thereof has the structure of Formula (III-c):A -C(O)NH-(C1-C6-alkyl) and -C(O)NH-(C6-C 10 -aryl), wherein the C-C 10 -Aryl may be substituted with 1 to 3 C1-C6-alkyl.

[0117] In some embodiments, the compound of Formula (III) or a pharmaceutically acceptable salt thereof has the structure of Formula (III-d): B is a 5-10 membered heteroaryl (1-4 heteroaryl ring members independently selected from N, O, and S) or -S(O)2- (5-10 membered heteroaryl (1-4 heteroaryl ring members independently selected from N, O, and S)), and R B may be substituted with 1 to 3 C1-C6-alkyl.

[0118] Specific examples of compounds of formula (I) or pharmaceutically acceptable salts thereof constitute additional embodiments of the present disclosure, some of which are illustrated through the examples and set forth in Table 1 below. In some embodiments, the compound of formula (I) is selected from the group consisting of:

[0119] 4-Methoxy-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-1H-indole-2-carboxamide; N-((S)-1-(((S)-4-(2,6-difluorophenoxy)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide; (S)-3-((S)-2-(4-methoxy-1H-indole-2-carboxamido)-4-methylpentanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butyl 2,6-dichlorobenzoate; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-1H-indole-2-carboxamide; N-((S)-3-cyclohexyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)-1H-indole-2-carboxamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-1H-indole-2-carboxamide; N-((S)-1-(((S)-4-(2,6-difluorophenoxy)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide; (S)-3-((S)-2-(4-methoxy-1H-indole-2-carboxamido)-4-methylpentanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butyl 2,6-dichlorobenzoate; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)benzamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-phenyloxalamide; 5-fluoro-N-((S)-5-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)hexan-2-yl)-1H-indole-2-carboxamide; 5-fluoro-N-((S)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)-4-phenylbutan-2-yl)-1H-indole-2-carboxamide; N-((S)-4,4-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-5-fluoro-1H-indole-2-carboxamide; 5-fluoro-N-((S)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)-3-phenylpropan-2-yl)-1H-indole-2-carboxamide; benzyl ((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)carbamate; 5-fluoro-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-1H-indole-2-carboxamide; 5-fluoro-N-((S)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)-3-(4-(trifluoromethyl)phenyl)propan-2-yl)-1H-indole-2-carboxamide; 5-fluoro-N-((S)-4-fluoro-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-1H-indole-2-carboxamide; 5-fluoro-N-((2S)-3-(4-methoxyphenyl)-1-oxo-1-(((2S)-3-oxo-1-(2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)-1H-indole-2-carboxamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)quinoline-2-carboxamide; Cyclopentyl ((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)carbamate; 3-chlorobenzyl ((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)carbamate; 4-Fluorobenzyl ((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)carbamate; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)benzo[d][1,3]dioxole-5-carboxamide; 1-(Cyclopentanecarbonyl)-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)piperidine-4-carboxamide; (R)—N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)tetrahydrofuran-2-carboxamide; 1-(Cyclopentanecarbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)piperidine-4-carboxamide; N1-(2-fluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide; N1-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)-N2-phenyloxalamide; N1-((S)-3-cyclobutyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)-N2-phenyloxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-(2-(trifluoromethyl)phenyl)oxalamide; N1-(2-(tert-butyl)phenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-(naphthalen-2-yl)oxalamide; N1-((S)-3-cyclohexyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)-N2-phenyloxalamide; N1-((S)-5-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)hexan-2-yl)-N2-phenyloxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-(o-tolyl)oxalamide; N1-(4-fluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(4-chlorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; (S)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)-2-(2-(phenylamino)acetamido)pentanamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-phenethyloxalamide; N1-benzyl-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(3-fluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-3-cyclopentyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)-N2-phenyloxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-(pyridin-2-yl)oxalamide; N1-(2-chlorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide N1-(2,6-difluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-(2-(trifluoromethyl)pyridin-3-yl)oxalamide; N1-((2S)-1-(((2S)-3-hydroxy-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-N2-phenyloxalamide; (S)-3-((S)-2-(5-fluoro-1H-indole-2-carboxamido)-4-methylpentanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butyl diphenylphosphinate; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-(naphthalen-1-yl)oxalamide; N1-(3-chlorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(3,4-difluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; (R)-N4-(2-fluorobenzyl)-2-isobutyl-N1-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)succinimide; (R)-N4-(2,6-difluorobenzyl)-2-isobutyl-N1-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)succinimide; N1-(2-bromophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2-benzylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pent-4-en-2-yl)-N2-phenyloxalamide; N1-(2,5-dichlorobenzyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; (S)-2-((E)-3-(2-fluorophenyl)acrylamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)pentanamide; N1-((S)-3-cyclohexyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)-N2-(2-fluorophenyl)oxalamide; N1-(2-(difluoromethoxy)phenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2-ethylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2,6-dimethylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2,3-dimethylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; S)-2-Cinnamamido-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)pentanamide; 5-(2-fluorophenyl)-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)isoxazole-3-carboxamide; N1-(2-fluoro-4-methylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-cyclohexyl-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-5-phenylisoxazole-3-carboxamide; N1-(2,3-difluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2,5-difluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; (S)-3-((S)-4-methyl-2-(2-oxo-2-(phenylamino)acetamido)pentanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butyl diphenylphosphinate; N1-(4-fluoro-2-methylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2-cyanophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(3,3-difluoro-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-(2-fluorophenyl)oxalamide; N1-(4-chloro-2-methylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2,4-difluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(5-fluoro-2-methoxyphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-1-(((S)-1-cyclohexyl-3-oxo-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-N2-(2-fluorophenyl)oxalamide; N1-(cyclopentylmethyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2-fluoro-6-methylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(5-fluoro-2-methylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; (S)-2-(3-(2-fluorophenyl)ureido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)pentanamide; N1-(2-fluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2-isopropylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(4-bromo-3,5-difluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2-chlorophenyl)-N2-((S)-3-(4,4-difluorocyclohexyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)oxalamide; N1-(3-fluoro-2-methylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2-fluorophenyl)-N2-((S)-3-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)butan-2-yl)oxalamide; (S)-1-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)pyrrolidine-2-carboxamide; N1-(2-chlorophenyl)-N2-((S)-3-cyclohexyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)oxalamide; N1-((S)-3-cyclohexyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)-N2-(o-tolyl)oxalamide; N1-(3,3-difluorocyclohexyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; (R)-1-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)piperidine-3-carboxamide; N1-(4-bromo-2-fluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; (2S)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)-2-(3,3,3-trifluoro-2-((2-fluorophenyl)amino)propanamido)pentanamide; N1-cyclopropyl-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-(1-methylcyclopropyl)oxalamide; N1-(tert-butyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-(tetrahydro-2H-pyran-4-yl)oxalamide; N1-cyclopentyl-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-((S)-tetrahydro-2H-pyran-3-yl)oxalamide; (S)-2-(2-(4-acetylpiperazin-1-yl)-2-oxoacetamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)pentanamide; N1-methyl-N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-(o-tolyl)oxalamide; N1-((S)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)-3-phenylpropan-2-yl)-N2-(o-tolyl)oxalamide; N1-methyl-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N1-(o-tolyl)oxalamide; N1-((S)-4-cyclohexyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)butan-2-yl)-N2-(2-fluorophenyl)oxalamide; N1-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)-N2-(2-fluorophenyl)oxalamide; N-((S)-3-cyclohexyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)-5-(2-fluorophenyl)isoxazole-3-carboxamide; N1-(2-benzylphenyl)-N2-((S)-3-cyclohexyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)oxalamide; N1-(2-methoxyphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-(2-(trifluoromethoxy)phenyl)oxalamide; 5-methyl-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)isoxazole-3-carboxamide; 5-methyl-N-((S)-3-methyl-1-(((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)amino)-1-oxobutan-2-yl)isoxazole-3-carboxamide; N1-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)-N2-(o-tolyl)oxalamide; N1-(2-(tert-butyl)phenyl)-N2-((S)-3-cyclohexyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)oxalamide; N-((S)-3,3-dimethyl-1-(((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)amino)-1-oxobutan-2-yl)-5-methylisoxazole-3-carboxamide; N1-((S)-3,3-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)butan-2-yl)-N2-(2-fluorophenyl)oxalamide; N1-(3-methoxyphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(4-methoxyphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-phenyloxalamide; N1-((S)-1-(((S)-6-(dimethylamino)-2,6-dioxo-1-(2,3,5,6-tetrafluorophenoxy)hexan-3-yl)amino)-4-methyl-1-oxopentan-2-yl)-N2-(2-fluorophenyl)oxalamide; N1-cyclobutyl-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; (S)-3-((S)-2-(2-((2-fluorophenyl)amino)-2-oxoacetamido)-4-methylpentanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butyl diphenylphosphinate; (R)-Tetrahydrofuran-3-yl((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)carbamate; (S)-Tetrahydrofuran-3-yl((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)carbamate; 3-(3-chlorophenyl)propyl((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)carbamate; N1-(2-fluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopiperidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4,4-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-(2-fluorophenyl)oxalamide; N1-(2-fluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,4,6-trifluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2-fluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,6-trifluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-((R)-tetrahydro-2H-pyran-3-yl)oxalamide; N1-(2-chlorophenyl)-N2-(1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)-3-(tetrahydro-2H-pyran-4-yl)propan-2-yl)oxalamide; N1-((S)-1-(((S)-1-(1H-imidazol-5-yl)-3-oxo-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-N2-(2-fluorophenyl)oxalamide; N1-((S)-1-(((R)-1-(1H-imidazol-5-yl)-3-oxo-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-N2-(2-fluorophenyl)oxalamide; Cyclopentyl methyl ((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)carbamate; 3-chlorophenethyl ((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)carbamate; (E)-3-(3-chlorophenyl)allyl((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)carbamate; N1-(1-acetylpiperidin-4-yl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2-fluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-((5-(trifluoromethyl)isoxazol-3-yl)oxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-1-(((S)-7-amino-2-oxo-1-(2,3,5,6-tetrafluorophenoxy)heptan-3-yl)amino)-4-methyl-1-oxopentan-2-yl)-N2-(2-fluorophenyl)oxalamide; N1-(2-(methoxymethyl)phenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; (S)-2-(2-(3-chlorophenyl)acetamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)pentanamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-((S)-1,2,3,4-tetrahydronaphthalen-1-yl)oxalamide; (S)-2-((R)-2-(3-chlorophenyl)-2-hydroxyacetamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)pentanamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-((R)-1,2,3,4-tetrahydronaphthalen-1-yl)oxalamide; N1-((S)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)-3-(pyridin-2-yl)propan-2-yl)-N2-(o-tolyl)oxalamide; (S)-2-(2-(3,4-dihydroquinolin-1(2H)-yl)-2-oxoacetamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)pentanamide; (3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)carbamate; N1-(4,4-difluorocyclohexyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2,6-dimethylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; 2,2-Difluoro-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)benzo[d][1,3]dioxole-5-carboxamide; (S)-2-(2-(5-acetyl-2-methoxyphenyl)acetamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)pentanamide; N1-((S)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)-3-(pyridin-2-yl)propan-2-yl)-N2-(o-tolyl)oxalamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1H-benzo[d]imidazole-2-carboxamide; N-((S)-1-(((S)-4-((1,1,1,3,3,3-hexafluoropropan-2-yl)oxy)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide; 4-Methoxy-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1H-indole-2-carboxamide; N1-(2,6-diisopropylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-5-(2-fluorophenyl)isoxazole-3-carboxamide; N-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-5-fluoro-1H-indole-2-carboxamide; 4-Methoxy-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,2,2-trifluoroethoxy)butan-2-yl)amino)pentan-2-yl)-1H-indole-2-carboxamide; N1-cyclohexyl-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2,6-dimethoxyphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2-methoxy-6-methylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2-fluoro-6-methoxyphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2,6-diethylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)benzo[d][1,3]dioxole-5-carboxamide; N1-(2,2-difluorocyclohexyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2,6-diisopropoxyphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; 5-(2-fluorophenyl)-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)isoxazole-3-carboxamide; N1-(tert-butyl)-N2-((S)-4,4-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2-(tert-butyl)phenyl)-N2-((S)-4,4-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-cyclopropyl-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2-fluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-((1,1,3,3-tetrafluoropropan-2-yl)oxy)butan-2-yl)amino)pentan-2-yl)oxalamide; 1-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(3,3-difluorocyclobutyl)oxalamide; N1-(2-(methoxymethyl)phenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; 4-Methoxy-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-((1,1,3,3-tetrafluoropropan-2-yl)oxy)butan-2-yl)amino)pentan-2-yl)-1H-indole-2-carboxamide; N1-(3,3-difluorocyclobutyl)-N2-((S)-4,4-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(tert-butyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(tert-butyl)-N2-(1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)-3-(tetrahydro-2H-pyran-4-yl)propan-2-yl)oxalamide; N1-(3,3-difluorocyclobutyl)-N2-((S)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)-3-phenylpropan-2-yl)oxalamide; 5-(2-fluorophenyl)-N-(1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)-3-(tetrahydro-2H-pyran-4-yl)propan-2-yl)isoxazole-3-carboxamide; N-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-5-(4-fluorophenyl)-1,3,4-oxadiazole-2-carboxamide; N1-(2,6-dicyclopropylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(1-(p-tolyl)cyclopropyl)oxalamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; N1-(3-methoxyphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(2,2,2-trifluoroethyl)oxalamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-2-oxopiperidine-3-carboxamide N1-(bicyclo[1.1.1]pentan-1-yl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-3-phenyl-1H-pyrazole-5-carboxamide; N1-(1-methoxy-2-methylpropan-2-yl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1H-pyrrolo[2,3-b]pyridine-2-carboxamide; (3S)-3-((S)-2-(4-methoxy-1H-indole-2-carboxamido)-4-methylpentanamido)-2-oxo-4-(2-oxopyrrolidin-3-yl)butyl diphenylphosphinate; (2S)-2-(2-(3,4-dihydroquinolin-1(2H)-yl)-2-oxoacetamido)-4-methyl-N-((2S)-3-oxo-1-(2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; N1-(2-fluorophenyl)-N2-((S)-3-methyl-1-(1-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)-1H-1,2,3-triazol-4-yl)butyl)oxalamide; N-((S)-1-(((S)-4-(difluoromethoxy)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide; 3-chlorobenzyl ((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)carbamate; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide; N-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)benzo[d]oxazole-2-carboxamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)imidazo[1,2-a]pyridine-2-carboxamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)imidazo[1,2-b]pyridazine-2-carboxamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)indoline-2-carboxamide; N1-(3,3-difluorocyclobutyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(o-tolyl)oxalamide; (S)-2-((R)-2-hydroxy-3-phenylpropanamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; N-((S)-6-amino-1-(((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)amino)-1-oxohexan-2-yl)-2-fluorobenzamide; 5-(3-fluorophenyl)-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1H-imidazole-2-carboxamide; 5-(2-Methoxyphenyl)-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1H-imidazole-2-carboxamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(1,1,1-trifluoro-2-methylpropan-2-yl)oxalamide; N1-((S)-3-cyclohexyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(1,1,1-trifluoro-2-methylpropan-2-yl)oxalamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-5-oxotetrahydrofuran-2-carboxamide; 2-methyl-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)tetrahydrofuran-2-carboxamide; N1-((S)-3-(3-fluorophenyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(1-methylcyclopropyl)oxalamide; N1-(1-(2-fluorophenyl)cyclopropyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(1-methylcyclopropyl)oxalamide; N1-(2-fluorophenyl)-N2-((2S)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)-3-(2-oxopyrrolidin-3-yl)propan-2-yl)oxalamide; N1-(2-fluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopiperidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(3,3-difluoro-1-methylcyclobutyl)oxalamide; N1-cyclobutyl-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(4-methyltetrahydro-2H-pyran-4-yl)oxalamide; N-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-5-phenyl-1H-imidazole-2-carboxamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-5-phenyl-1H-imidazole-2-carboxamide; (R)—N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)tetrahydrofuran-2-carboxamide; N1-((S)-4,4-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(3-fluorobicyclo[1.1.1]pentan-1-yl)oxalamide; N1-((2S)-3-(2,2-difluorocyclopentyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(2-fluorophenyl)oxalamide; N1-(2-fluorophenyl)-N2-((S)-1-(((S)-6-guanidino-2-oxo-1-(2,3,5,6-tetrafluorophenoxy)hexan-3-yl)amino)-4-methyl-1-oxopentan-2-yl)oxalamide; 4-Methoxy-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopiperidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1H-indole-2-carboxamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)tetrahydrofuran-3-carboxamide; N1-(1-(hydroxymethyl)cyclopropyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(piperidin-4-yl)oxalamide; 4-Methoxy-N-((S)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)-5-phenylpentan-2-yl)-1H-indole-2-carboxamide; N1-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(1,1-dioxidothietan-3-yl)oxalamide; (S)-2-((R)-2-((2-fluorophenyl)amino)-3-methoxypropanamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; (S)-2-((S)-2-((2-fluorophenyl)amino)-3-methoxypropanamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(1-(trifluoromethyl)cyclopropyl)oxalamide; N1-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(3-(methoxymethyl)oxetan-3-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(2-oxaspiro[3.3]heptan-6-yl)oxalamide; N1-(6,6-difluorospiro[3.3]heptan-2-yl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-3-(3-fluorophenyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(3-methoxyphenyl)oxalamide; N1-(2-fluorophenyl)-N2-((S)-3-(3-fluorophenyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(oxetan-3-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopiperidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(1-methylcyclopropyl)oxalamide; N1-(1,1-difluoro-2-methylpropan-2-yl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1,4-dioxane-2-carboxamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1H-pyrrolo[3,2-b]pyridine-2-carboxamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide; N1-((S)-3-(4-fluorophenyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(1-methylcyclopropyl)oxalamide; N1-(4-fluorobicyclo[2.2.2]octan-1-yl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(3-methylpyrrolidin-3-yl)oxalamide; 5-(2-fluoropropan-2-yl)-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)isoxazole-3-carboxamide; N1-(1-(fluoromethyl)cyclopropyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; 7-Methoxy-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-2,3-dihydrobenzofuran-2-carboxamide; (1S,3aR,6aS)-2-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; N1-(2-fluorophenyl)-N2-(4-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)tetrahydro-2H-pyran-4-yl)oxalamide; (2S,4R)-1-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-4-methoxy-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pyrrolidine-2-carboxamide; 5-fluoro-N-((1R,2S)-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-2-vinylcyclopropyl)-1H-indole-2-carboxamide; (1S,3aR,6aS)-2-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; N-((1R,2R)-2-ethyl-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)cyclopropyl)-5-fluoro-1H-indole-2-carboxamide; N1-(1-(methoxymethyl)cyclopropyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1H-pyrrolo[3,2-b]pyridine-3-carboxamide; (1R,2S,5S)-3-((S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,3S,5R)-2-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-azabicyclo[3.1.0]hexane-3-carboxamide; (1S,3aR,6aS)-2-((S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; N1-(1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)-3-(tetrahydro-2H-pyran-4-yl)propan-2-yl)-N2-(2,2,2-trifluoroethyl)oxalamide; (2S,4R)-1-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-4-(trifluoromethyl)pyrrolidine-2-carboxamide; (3aS,4S,6aR)-5-((S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)hexahydro-1H-furo[3,4-c]pyrrole-4-carboxamide; (1S,3aR,6aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(1-(2,2,2-trifluoroacetamido)cyclopropane-1-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(1-(2,2,2-trifluoroacetamido)cyclobutane-1-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((1S,2R)-2-methyl-1-(2,2,2-trifluoroacetamido)cyclopropane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,2S,5S)-3-((S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azaspiro[bicyclo[3.1.0]hexane-6,1′-cyclopropane]-2-carboxamide; (1S,3aR,7aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(2-(trifluoromethyl)thiazole-4-carbonyl)octahydro-1H-isoindole-1-carboxamide; (1S,3aR,7aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(5-(trifluoromethyl)isoxazole-3-carbonyl)octahydro-1H-isoindole-1-carboxamide; (2S,3aS,7aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-1-(2-oxo-2-((1,1,1-trifluoro-2-methylpropan-2-yl)amino)acetyl)octahydro-1H-indole-2-carboxamide; (1R,2S,5S)-3-((N-(2-fluorophenyl)sulfamoyl)carbonyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-3-(N-(2-fluorophenyl)sulfamoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,2R,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-(N-(2,2,2-trifluoroacetyl)-O-(trifluoromethyl)-L-threonyl)bicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-3-(O-(difluoromethyl)-N-(2,2,2-trifluoroacetyl)-L-seryl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide (1S,2R,5S)-3-(O-(difluoromethyl)-N-(2,2,2-trifluoroacetyl)-L-threonyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)bicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-3-((S)-3-(3,3-difluoroazetidin-1-yl)-2-(2,2,2-trifluoroacetamido)propanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-(3-(2,2,2-trifluoroacetamido)cyclobutane-1-carbonyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-3-((S)-3,3-dimethyl-2-((R)-tetrahydrofuran-2-carboxamido)butanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-((R)-tetrahydrofuran-2-carbonyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((2S)-3-oxo-1-(2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-((R)-4,4,4-trifluoro-2-hydroxybutanoyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; N-((S)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)butan-2-yl)-5-oxaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(5-oxaspiro[2.4]heptane-6-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (2R)—N-(1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)-3-(tetrahydro-2H-pyran-4-yl)propan-2-yl)tetrahydrofuran-2-carboxamide; (1S,3aR,6aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-((R)-tetrahydrofuran-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (R)—N-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)tetrahydrofuran-2-carboxamide; (R)—N-((S)-4,4-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)tetrahydrofuran-2-carboxamide; (S)—N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)tetrahydrofuran-2-carboxamide; (1R,3S,5R)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-((R)-tetrahydrofuran-2-carbonyl)-2-azabicyclo[3.1.0]hexane-3-carboxamide; (1R,3S,5R)-N-(3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-((S)-tetrahydrofuran-2-carbonyl)-2-azabicyclo[3.1.0]hexane-3-carboxamide; (S)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((R)-tetrahydrofuran-2-carbonyl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((R)-1,4-dioxane-2-carbonyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-3-((S)-1,4-dioxane-2-carbonyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,3aR,6aS)-2-(7-oxabicyclo[2.2.1]heptane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-7-oxabicyclo[2.2.1]heptane-1-carboxamide; (1S,3aR,6aS)-2-(2-methyltetrahydrofuran-2-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (6S)-5-(2-methyltetrahydrofuran-2-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-(4-methyl-2-oxabicyclo[2.1.1]hexane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; 4-methyl-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-2-oxabicyclo[2.1.1]hexane-1-carboxamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-4-(2,2,2-trifluoroacetamido)-2-oxabicyclo[2.1.1]hexane-1-carboxamide; (1S,3aR,6aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(4-(trifluoromethyl)-2-oxabicyclo[2.1.1]hexane-1-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-4-(trifluoromethyl)-2-oxabicyclo[2.1.1]hexane-1-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(4-(trifluoromethyl)-2-oxabicyclo[2.1.1]hexane-1-carbonyl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-(4-(trifluoromethyl)-2-oxabicyclo[2.1.1]hexane-1-carbonyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; 4-(Difluoromethyl)-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-2-oxabicyclo[2.1.1]hexane-1-carboxamide; (S)-5-(4-(difluoromethyl)-2-oxabicyclo[2.1.1]hexane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-(4-(difluoromethyl)-2-oxabicyclo[2.1.1]hexane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,2S,5S)-3-(4-(difluoromethyl)-2-oxabicyclo[2.1.1]hexane-1-carbonyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,3aR,6aS)-2-(3,3-difluorotetrahydrofuran-2-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; 3,3-difluoro-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)tetrahydrofuran-2-carboxamide; (1R,3S,5R)-N-(3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-((S)-tetrahydrofuran-2-carbonyl)-2-azabicyclo[3.1.0]hexane-3-carboxamide; (R)-3,3-dimethyl-1-oxo-1-((S)-6-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-5-azaspiro[2.4]heptan-5-yl)butan-2-yl tert-butylcarbamate; (R)-4-methyl-1-oxo-1-((S)-6-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-5-azaspiro[2.4]heptan-5-yl)pentan-2-yl tert-butylcarbamate; (R)-4-methyl-1-oxo-1-((S)-6-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-5-azaspiro[2.4]heptan-5-yl)pentan-2-yl isopropylcarbamate; (R)-4-methyl-1-oxo-1-((S)-6-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-5-azaspiro[2.4]heptan-5-yl)pentan-2-ylcyclohexylcarbamate; (R)-4-methyl-1-oxo-1-((S)-6-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-5-azaspiro[2.4]heptan-5-yl)pentan-2-ylphenylcarbamate; (R)-3,3-dimethyl-1-oxo-1-((S)-6-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-5-azaspiro[2.4]heptan-5-yl)butan-2-ylethylcarbamate; (S)-5-((R)-2-(difluoromethoxy)-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R)-2-(2-hydroxy-2-methylpropoxy)-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-((R)-2-(trifluoromethoxy)butanoyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-3-((R)-2-methoxybutanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-2-((R)-2-methoxybutanamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; (6S)-5-(2-methoxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((S)-2-methoxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2,2-dimethoxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-2-((R)-2-hydroxy-3,3-dimethylbutanamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; (S)-5-((R)-2-hydroxy-3,3-dimethylbutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((R)-2-hydroxy-3,3-dimethylbutanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-5-((S)-2-hydroxy-3,3-dimethylbutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((S)-2-hydroxy-3,3-dimethylbutanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (6S)-5-(2-hydroxy-4,4-dimethylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-(2-hydroxy-4,4-dimethylpentanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,3aR,6aS)-2-(2-hydroxy-4,4-dimethylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-5-((S)-2-hydroxy-4,4-dimethylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((S)-4-fluoro-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-(2-hydroxy-2-methylpropanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,3aR,6aS)-2-(2-hydroxy-2-methylpropanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-2-(2-hydroxy-2-methylpropanamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; (S)-5-(2-hydroxy-2-methylpropanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-2-((R)-2-hydroxy-3-methylbutanamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; (S)-5-((R)-2-hydroxy-3-methylbutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((R)-2-hydroxy-3-methylbutanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-5-((S)-2-hydroxy-3-methylbutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-((R)-2-hydroxy-3-methylbutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (6S)-5-(2-hydroxy-2,4-dimethylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((R)-2-hydroxy-4-methylpentanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-5-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-5-((S)-2-hydroxy-2-phenylpropanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R)-2-hydroxy-2-phenylpropanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(1-hydroxy-3,3-dimethylcyclobutane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((S)-2-hydroxy-2-methylbutanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-3-((R)-2-hydroxybutanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-2-((R)-2-hydroxybutanamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; (1R,2S,5S)-3-((S)-2-hydroxybutanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-5-((R)-2-hydroxybutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (2R)-2-hydroxy-N-(3-(1-methylcyclopropyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)butanamide; (2S,3aS,7aS)-1-((R)-2-hydroxybutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydro-1H-indole-2-carboxamide; (2S,3aS,6aS)-1-((R)-2-hydroxybutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[b]pyrrole-2-carboxamide; (R)-2-hydroxy-N-((R)-3-(1-methylcyclopropyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)butanamide; (R)-2-hydroxy-N-((S)-3-(1-methylcyclopropyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)butanamide; (1S,3aR,6aS)-2-((R)-2-hydroxybutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,2S,5S)-3-((R)-2-hydroxypentanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,3aR,6aS)-2-((2R,3R)-2-hydroxy-3-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-5-((2R,3R)-2-hydroxy-3-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R)-2-methoxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((R)-2-hydroxy-2-(2-methoxyphenyl)acetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (6S)-5-(2-hydroxy-2-(1-methyl-1H-imidazol-5-yl)acetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-((S)-3,3,3-trifluoro-2-hydroxypropanamido)pentanamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((S)-3,3,3-trifluoro-2-hydroxypropanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-((S)-3,3,3-trifluoro-2-hydroxypropanoyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((R)-3,3,3-trifluoro-2-hydroxypropanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (6S)-5-(2-(1,1-dioxidetetrahydro-2H-thiopyran-4-yl)-2-hydroxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (6S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(5,5,5-trifluoro-2-hydroxy-4-(trifluoromethyl)pentanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (6S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(4,4,4-trifluoro-2-hydroxybutanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-(4,4,4-trifluoro-2-hydroxybutanoyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-5-((R)-3-cyclopropyl-2-hydroxypropanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-((R)-3-cyclopropyl-2-hydroxypropanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,2S,5S)-3-((S)-3-cyclopropyl-2-hydroxypropanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (6S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(5,5,5-trifluoro-2-hydroxypentanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-2-((S)-3-fluoro-2-hydroxypropanamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; (S)-5-((S)-3-fluoro-2-hydroxypropanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R)-2-hydroxy-3-phenylpropanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (6S)-5-(2-hydroxy-2-(3,4,5-trifluorophenyl)acetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (6S)-5-(2-(3,4-difluorophenyl)-2-hydroxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-(2-(3,4-difluorophenyl)-2-hydroxyacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (6S)-5-(2-(2,4-difluorophenyl)-2-hydroxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R)-2-(4-fluorophenyl)-2-hydroxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-((R)-2-(4-fluorophenyl)-2-hydroxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (6S)-5-(2-(3-fluorophenyl)-2-hydroxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (6S)-5-(2-hydroxy-2-(2-(trifluoromethyl)phenyl)acetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((R)-2-(2-fluorophenyl)-2-hydroxyacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-2-((R)-2-(2-fluorophenyl)-2-hydroxyacetamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; (1S,3aR,6aS)-2-((R)-2-(2-fluorophenyl)-2-hydroxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-5-((R)-2-(2-fluorophenyl)-2-hydroxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((S)-2-(2-fluorophenyl)-2-hydroxyacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-5-((R)-2-hydroxy-2-phenylacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((R)-2-hydroxy-2-phenylacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,3aR,6aS)-2-((R)-2-hydroxy-2-phenylacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-5-((S)-2-hydroxy-2-phenylacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((S)-2-hydroxy-2-phenylacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,3aR,6aS)-2-((S)-2-hydroxy-2-phenylacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (6S)-5-(2-hydroxy-2-(pyridin-2-yl)acetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (6S)-5-(2-hydroxy-2-(pyridin-3-yl)acetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(1-hydroxycyclopropane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(4,4-difluoro-1-hydroxycyclohexane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(1-hydroxycyclobutane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(1-hydroxycyclopentane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(1-hydroxycyclohexane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-((R)-2-hydroxypentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((2R,4R)-5,5,5-trifluoro-2-hydroxy-4-methylpentanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((2R,4S)-5,5,5-trifluoro-2-hydroxy-4-methylpentanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(4-methyl-2-oxopentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(4-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R)-3-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((S)-3-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; Methyl ((S)-3,3-dimethyl-1-oxo-1-((S)-6-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-5-azaspiro[2.4]heptan-5-yl)butan-2-yl)carbamate; (S)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(2-((1-(trifluoromethyl)cyclopropyl)amino)acetamido)pentanamide; (S)-5-((methylcarbamoyl)-D-leucyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((S)-2-acetamido-3,3-dimethylbutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((2-fluorobenzoyl)glycyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; tert-butyl ((R)-1-((1R,2S,5S)-6,6-dimethyl-2-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-3-azabicyclo[3.1.0]hexan-3-yl)-1-oxobutan-2-yl)carbamate; (1R,2S,5S)-3-((R)-2-aminobutanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,3aR,6aS)-2-(methylprolyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-5-((S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-(3-(4,4-difluoropiperidin-1-yl)-2-(2,2,2-trifluoroacetamido)propanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-5-((S)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-(2-(2-chlorophenyl)-2-hydroxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; Cyclopropyl ((S)-1-((1R,2S,5S)-6,6-dimethyl-2-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-3-azabicyclo[3.1.0]hexan-3-yl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate; (S)-5-(2-ethylbutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,3S,5R)-2-((R)-2-hydroxy-4-methylpentanoyl)-5-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-azabicyclo[3.1.0]hexane-3-carboxamide; (S)-5-((R)-4,4-difluoro-2-hydroxybutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-((R)-4,4-difluoro-2-hydroxybutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3S,5R)-2-((R)-2-hydroxy-3-methylbutanoyl)-5-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-azabicyclo[3.1.0]hexane-3-carboxamide; (S)-5-(4-(tert-butyl)benzoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((R)-2-hydroxy-4,4-dimethylpentanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-5-(2-(3-(tert-butyl)phenyl)-2-methylpropanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-methyl-2-(3-(trifluoromethyl)phenyl)propanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(3-(trifluoromethyl)benzoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(3-(tert-butyl)benzoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(4,4-dimethylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; 5-(2-fluorophenyl)-N-((S)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)-3-phenylpropan-2-yl)isoxazole-3-carboxamide; N-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-5-(phenylamino)-1,3,4-oxadiazole-2-carboxamide; 5-benzyl-N-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)isoxazole-3-carboxamide; (S)-4-methyl-2-((1-methyl-1H-indole)-5-sulfonamido)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-5-(pyridin-2-yl)isoxazole-3-carboxamide; (S)-4-methyl-2-((2-oxo-1,2-dihydroquinolin-3-yl)amino)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; 7-Methoxy-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)benzofuran-2-carboxamide; (1S,3aR,6aS)-2-(2-(cyclohexylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-(2-(trifluoromethyl)thiazole-4-carbonyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-6,6-dimethyl-3-(2-((1-methylcyclopropyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-3-(2-(cyclohexylamino)-2-oxoacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopiperidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-3-(2-(tert-butylamino)-2-oxoacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(2-oxo-2-((1,1,1-trifluoro-2-methylpropan-2-yl)amino)acetyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-(2-oxo-2-(o-tolylamino)acetyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-(5-(trifluoromethyl)isoxazole-3-carbonyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-(2-oxo-2-((1-(trifluoromethyl)cyclopropyl)amino)acetyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,3aR,6aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(2-(trifluoromethyl)thiazole-4-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,2S,5S)-3-(2-((3,3-difluorocyclobutyl)amino)-2-oxoacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-3-(5-(2-fluoropropan-2-yl)isoxazole-3-carbonyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-5-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; N1-(2-fluorophenyl)-N2-(1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)-3-(tetrahydro-2H-pyran-4-yl)propan-2-yl)oxalamide; N-((2S)-4-methyl-1-oxo-1-(((2S)-3-oxo-1-(2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-2-(trifluoromethyl)thiazole-4-carboxamide; (6S)-1,1-difluoro-5-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(5-(trifluoromethyl)isoxazole-3-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,2S,5S)-3-(2-((2,2-difluoropropyl)amino)-2-oxoacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (3S,4S)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-1-(2-oxo-2-((1,1,1-trifluoro-2-methylpropan-2-yl)amino)acetyl)pyrrolidine-3-carboxamide; (1R,2S,5S)-3-(2-((3-fluorobicyclo[1.1.1]pentan-1-yl)amino)-2-oxoacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (3S,4aS,8aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(2-oxo-2-((1,1,1-trifluoro-2-methylpropan-2-yl)amino)acetyl)decahydroisoquinoline-3-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-(3-(trifluoromethyl)isoxazole-5-carbonyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-3-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; N-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-5-(2-fluoropropan-2-yl)isoxazole-3-carboxamide; (1S,3aR,6aS)-2-(5-(2-fluoropropan-2-yl)isoxazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((R)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-(3-(trifluoromethyl)isoxazole-5-carbonyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,2S,5R)-3-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,3aR,6aS)-2-(2-((1-methylcyclopropyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(2-((1-methylcyclopropyl)amino)-2-oxoacetyl)-N-((R)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(2-(tert-butylamino)-2-oxoacetyl)-N-((R)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(2-(cyclopropylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (2S,3aS,7aS)-1-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydro-1H-indole-2-carboxamide; 5-(2-fluoropropan-2-yl)-N-(1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)-3-(tetrahydro-2H-pyran-4-yl)propan-2-yl)isoxazole-3-carboxamide; (1S,3aR,6aS)-2-(5-(difluoromethyl)isoxazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,2S)-3-(5-(2-fluoropropan-2-yl)isoxazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hex-4-ene-2-carboxamide; (S)-5-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; N1-(tert-butyl)-N2-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)oxalamide; N1-((S)-4,4-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(o-tolyl)oxalamide; N1-((S)-4,4-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(2,2,2-trifluoroethyl)oxalamide; N1-(3-fluorobicyclo[1.1.1]pentan-1-yl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(o-tolyl)oxalamide; 6-(2-(tert-butylamino)-2-oxoacetyl)-2,2-difluoro-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-6-azaspiro[3.4]octane-7-carboxamide; N1-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(3-fluorobicyclo[1.1.1]pentan-1-yl)oxalamide; N1-(3-fluorobicyclo[1.1.1]pentan-1-yl)-N2-(1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)-3-(tetrahydro-2H-pyran-4-yl)propan-2-yl)oxalamide; 6-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-6-azaspiro[3.4]octane-7-carboxamide; N1-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(1-(trifluoromethyl)cyclopropyl)oxalamide; (1S,3aR,6aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(2-oxo-2-(o-tolylamino)acetyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (R)-6-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-oxa-6-azaspiro[3.4]octane-7-carboxamide; (S)-6-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-oxa-6-azaspiro[3.4]octane-7-carboxamide; (1R,2S,5S)-3-(2-((2,2-difluoroethyl)amino)-2-oxoacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; N1-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(2,2,2-trifluoroethyl)oxalamide; (3R,6S)-5-(2-(tert-butylamino)-2-oxoacetyl)-1,1-difluoro-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-(2-((2,2-difluoroethyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(2-(tert-butylamino)-2-oxoacetyl)-5,5-difluoro-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3S,5R)-2-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-azabicyclo[3.1.0]hexane-3-carboxamide; 2-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-8-oxa-2-azaspiro[4.5]decane-3-carboxamide; (1S,3aR,6aS)-2-(2-((3,3-difluorocyclobutyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; N1-(1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)-3-(tetrahydro-2H-pyran-4-yl)propan-2-yl)-N2-(o-tolyl)oxalamide; (1S,3aR,6aS)-2-(2-((3-fluorobicyclo[1.1.1]pentan-1-yl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(2-oxo-2-((1,1,1-trifluoro-2-methylpropan-2-yl)amino)acetyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(2-oxo-2-(o-tolylamino)acetyl)-5-azaspiro[2.4]heptane-6-carboxamide; N1-((S)-4,4-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(2-fluorophenyl)oxalamide; N1-(tert-butyl)-N2-((S)-1-cyclopentyl-2-oxo-2-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)ethyl)-N2-methyloxalamide; 2-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-8-oxa-2-azaspiro[4.5]decane-3-carboxamide; 2-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-azaspiro[4.5]decane-3-carboxamide; 5-(Difluoromethyl)-N-((S)-4,4-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)isoxazole-3-carboxamide; (1S,3aR,6aS)-2-(1-methyl-1H-pyrazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(2-((1-methyl-1H-pyrazol-3-yl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,2S,5S)-6,6-dimethyl-3-(2-((1-methyl-1H-pyrazol-3-yl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-3-(2-((3,3-difluorocyclobutyl)amino)-2-oxoacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (2S,4R)-1-(2-(tert-butylamino)-2-oxoacetyl)-4-methoxy-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pyrrolidine-2-carboxamide; N-((S)-4,4-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-2-(trifluoromethyl)thiazole-5-carboxamide; (1S,3S,5S)-2-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-azabicyclo[3.1.0]hexane-3-carboxamide; (S)-4,4-dimethyl-1-(2-((1-methylcyclopropyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pyrrolidine-2-carboxamide; (S)-4-(2-((1-methylcyclopropyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-4-azaspiro[2.4]heptane-5-carboxamide; (1R,3S,4S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(2-oxo-2-((2,2,2-trifluoroethyl)amino)acetyl)-2-azabicyclo[2.2.1]heptane-3-carboxamide; (S)-1-(2-((3,3-difluorocyclobutyl)amino)-2-oxoacetyl)-4,4-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pyrrolidine-2-carboxamide; (1S,3aR,6aS)-2-(2-morpholino-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(5-methylisoxazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3S,4R)-2-(2-((1-methylcyclopropyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-azabicyclo[2.2.1]heptane-3-carboxamide; (2R,3aS,5R,6aS)-4-(2-(tert-butylamino)-2-oxoacetyl)-2-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)hexahydro-2H-furo[3,2-b]pyrrole-5-carboxamide; (1S,3aR,6aS)-2-(2-(((1R,5S,6r)-3-oxabicyclo[3.1.0]hexan-6-yl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(6,7-dihydro-4H-pyrano[3,4-d]isoxazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(2-((3-methylpyridin-2-yl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (2R,3aS,5S,6aS)-4-(2-(tert-butylamino)-2-oxoacetyl)-2-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)hexahydro-2H-furo[3,2-b]pyrrole-5-carboxamide; 1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N-(o-tolyl)-1H-1,2,3-triazole-4-carboxamide; (1R,2S,5S)-3-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azaspiro[bicyclo[3.1.0]hexane-6,1′-cyclopropane]-2-carboxamide; (1S,3aR,6aS)-2-(2-((1,1-difluoro-2-methylpropan-2-yl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,2S,5S)-3-(2-((1,1-difluoro-2-methylpropan-2-yl)amino)-2-oxoacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,3aR,6aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(benzo[d]isoxazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-6-(2-((1-methylcyclopropyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-6-azaspiro[3.4]octane-7-carboxamide; Tetrahydrofuran-3-yl(1S,3aR,6aS)-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)hexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate; (1s,4R)-2-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-azabicyclo[2.1.1]hexane-1-carboxamide; (1S,2S,5R)-3-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.2.0]heptane-2-carboxamide; (1s,4R)-2-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-azabicyclo[2.1.1]hexane-1-carboxamide; (1S,2S,5R)-3-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.2.0]heptane-2-carboxamide; N1-((S)-5,5-difluoro-4,4-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(3-fluorobicyclo[1.1.1]pentan-1-yl)oxalamide; N1-((S)-3-cyclobutyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(3-fluorobicyclo[1.1.1]pentan-1-yl)oxalamide; (1S,3aR,6aS)-2-(2-((2-cyanopropan-2-yl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (R)-1-(2-(tert-butylamino)-2-oxoacetyl)-2-(cyclopropylmethyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pyrrolidine-2-carboxamide; (S)-5-(5,5-dimethyl-4,5,6,7-tetrahydrobenzo[d]isoxazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; Methyl 2-oxo-2-((1S,3aR,6aS)-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)acetate; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(2-oxo-2-((2,2,2-trifluoroethyl)amino)acetyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-((1-methylcyclopropyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(5-(difluoromethyl)isoxazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; N1-(3-fluorobicyclo[1.1.1]pentan-1-yl)-N2-((S)-3-(1-methylcyclobutyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)oxalamide; (1S,3aR,6aS)-2-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-(2-oxo-1,2-dihydropyridin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-5-(2-((2-methoxyphenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(2-oxo-2-((2-(trifluoromethyl)phenyl)amino)acetyl)-5-azaspiro[2.4]heptane-6-carboxamide; N1-(1-methylcyclopropyl)-N2-(3-(1-methylcyclopropyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)oxalamide; N1-cyclopropyl-N2-(3-(1-methylcyclopropyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)oxalamide; N1-(3-fluorobicyclo[1.1.1]pentan-1-yl)-N2-((1S,2R)-2-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-[1,1′-bi(cyclopropane)]-2-yl)oxalamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1,2,4-oxadiazole-3-carboxamide; (1R,3S,5R)-2-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-5-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-azabicyclo[3.1.0]hexane-3-carboxamide; N1-(3-fluorobicyclo[1.1.1]pentan-1-yl)-N2-((S)-3-(1-methylcyclopropyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)oxalamide; (S)-1-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)azetidine-2-carboxamide; (S)-1-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)azepane-2-carboxamide; N1-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(1-methylcyclopropyl)oxalamide; N1-cyclopropyl-N2-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)oxalamide; (R)-5-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-((3,3-difluorocyclobutyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; N1-((S)-3-(3,4-difluorophenyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(2-fluorophenyl)oxalamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(2-oxo-2-((1,1,1-trifluoro-2-methylpropan-2-yl)amino)acetyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-((4-chloro-2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; N-(tert-butyl)-1-(4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1H-1,2,3-triazole-4-carboxamide; (S)-5-(3-fluoropicolinoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-(3,5-difluoro-2-hydroxybenzoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-5-((S)-3-hydroxy-2-phenylpropanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(3-(trifluoromethyl)bicyclo[1.1.1]pentan-1-yl)oxalamide; (S)-5-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-4,4,6-d3-6-carboxamide; (S)-5-(2-((2,3-difluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-((2-fluoro-3-methoxyphenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-((2-fluoro-3-(trifluoromethoxy)phenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-(2-(tert-butylamino)-2-oxoacetyl)-4-fluoro-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-5-(2-((2,5-difluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-((2-chloro-6-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-(5-fluoro-1H-indole-2-carbonyl)-N-((R)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-5-(4-methoxy-1H-indole-2-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-((2-chlorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-((3-chlorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(6-chlorobenzo[d]isoxazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(2-oxo-2-((2-(trifluoromethoxy)phenyl)amino)acetyl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-(6-fluorobenzo[d]isoxazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1,3,3-d3-1-carboxamide; (S)-5-(2-((2-(tert-butyl)phenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-(5-fluorobenzo[d]isoxazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(2-((2-(tert-butyl)phenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-5-(2,2-difluoro-2-phenylacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(L-leucyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-pentanoyl-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-methyl-2-phenylpropanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; benzyl ((S)-1-((1R,2S,5S)-6,6-dimethyl-2-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-3-azabicyclo[3.1.0]hexan-3-yl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate; (1S,3aR,6aS)-2-(2-(6-chloropyrazin-2-yl)-2-methoxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (R)-1-(2-fluorophenyl)-2-oxo-2-((1S,3aR,6aS)-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethyl 2-phenylacetate; (S)-5-(2,2-difluoro-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(4-fluoro-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(2,2,4-trimethylpentanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (R)-4-methyl-1-oxo-1-((S)-6-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-5-azaspiro[2.4]heptan-5-yl)pentan-2-ylpropionate; (S)-5-(3-fluorobicyclo[1.1.1]pentane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((S)-2-phenylpropanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-((S)-2-phenylpropanoyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-3-(4,4-difluoro-1-hydroxycyclohexane-1-carbonyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (R)-4-methyl-1-oxo-1-((S)-6-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-5-azaspiro[2.4]heptan-5-yl)pentan-2-yl isobutyrate; (R)-4-methyl-1-oxo-1-((S)-6-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-5-azaspiro[2.4]heptan-5-yl)pentan-2-yl 2-phenylacetate; (S)-5-(1-hydroxy-4,4-dimethylcyclohexane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((S)-2-(3-cyclopropylureido)-3,3-dimethylbutanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-5-(2,2-difluoroacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-1-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)piperidine-2-carboxamide; (2S,4R)-4-(tert-butyl)-1-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)piperidine-2-carboxamide; (1R,2S,5S)-3-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.2.1]octane-2-carboxamide; (S)-1-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)azepane-2-carboxamide; (S)-6-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-6-azaspiro[2.5]octane-5-carboxamide; (S)-1-((R)-2-hydroxy-4-methylpentanoyl)-4,4-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)piperidine-2-carboxamide; (S)-2-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; tert-butyl ((R)-4-methyl-1-oxo-1-((S)-6-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-5-azaspiro[2.4]heptan-5-yl)pentan-2-yl)carbamate; (S)-5-(D-leucyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; tert-butyl methyl ((R)-4-methyl-1-oxo-1-((S)-6-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-5-azaspiro[2.4]heptan-5-yl)pentan-2-yl)carbamate; (S)-5-(4,4-difluoro-1-methoxycyclohexane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-isopropoxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(2-phenylacetyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(1-hydroxy-4-(trifluoromethyl)cyclohexane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-3-((S)-2-(2-((2-fluorophenyl)amino)-2-oxoacetamido)-4-methylpentanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butylmethyl(phenyl)phosphinate; 4-fluoro-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-1H-indole-2-carboxamide; (S)-3-((S)-4-methyl-2-(2-oxo-2-(phenylamino)acetamido)pentanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butylmethyl(phenyl)phosphinate; N1-(2-fluorophenyl)-N2-((S)-4-methyl-1-(((S)-5-(methylthio)-2-oxo-1-(2,3,5,6-tetrafluorophenoxy)pentan-3-yl)amino)-1-oxopentan-2-yl)oxalamide; N1-(2-fluorophenyl)-N2-((S)-4-methyl-1-(((S)-5-(methylsulfonyl)-2-oxo-1-(2,3,5,6-tetrafluorophenoxy)pentan-3-yl)amino)-1-oxopentan-2-yl)oxalamide; (1R,2S,5S)-3-(5-(2-fluoropropan-2-yl)isoxazole-3-carbonyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,3aR,6aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(2-oxo-2-((1-(trifluoromethyl)cyclopropyl)amino)acetyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; 2-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-azaspiro[4.4]nonane-3-carboxamide; (1S,3aR,6aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-((1r,4S)-4-(trifluoromethyl)-2-oxabicyclo[2.1.1]hexane-1-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-5-((R)-2-hydroxy-4,4-dimethylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-(5-chlorobenzo[d]isoxazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-5-(methyl-D-leucyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(4,4-difluorocyclohexane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R)-2-hydroxypent-4-enoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(7-chloro-1H-indole-2-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-acetyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-pivaloyl-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R,E)-2-hydroxy-5-(4-methoxyphenyl)pent-4-enoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R,E)-5-(4-fluorophenyl)-2-hydroxypent-4-enoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R)-2-hydroxy-4-methylpentanoyl)-N-((R)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((N-phenylsulfamoyl)glycyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(3-((N-phenylsulfamoyl)amino)propanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (R)—N-((S)-3-(3-fluorophenyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-2-hydroxy-4-methylpentanamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((2,2,2-trifluoroethyl)glycyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(2-(2,2,2-trifluoroethoxy)acetyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(2-oxo-2-phenylacetyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R,E)-2-hydroxy-6-(methylsulfonamido)hex-4-enoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-(methylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; N1-((S)-3-(3-fluorophenyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-methyloxalamide; (S)-5-(4,4-difluoropentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((S)-tetrahydrofuran-2-carbonyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(4,4-difluoro-1-(2,2,2-trifluoroacetamido)cyclohexane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (6S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(3,3,3-trifluoro-2-hydroxy-2-phenylpropanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(tetrahydro-2H-pyran-4-carbonyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(4,4-difluorobutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(3,3,4,4-tetrafluorobutanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (2S,4R)-1-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-4-(trifluoromethyl)pyrrolidine-2-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(2-(trifluoromethyl)benzoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2,2-difluorobenzo[d][1,3]dioxole-5-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-propionyl-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(but-3-enoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(pent-4-enoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((N-methylsulfamoyl)glycyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((N,N-dimethylsulfamoyl)glycyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(N-(N,N-dimethylsulfamoyl)-N-methylglycyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-Benzoyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(1-isobutyl-1H-1,2,3-triazole-4-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-1-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pyrrolidine-2-carboxamide; (S)-5-((R)-2-hydroxypropanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-hydroxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(3,5-difluorobenzoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((S)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-(3,3-difluorocyclobutyl)acetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(4-chloro-2-fluorobenzoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(2,2,2-trifluoroacetyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-Isobutyryl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-Butyryl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R)-2-hydroxy-4-(methyl-13C)pentanoyl-1,2,3,4,5-13C5)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(3-methylbutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-Hexanoyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-2-acetamido-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; (S)-5-(2,4-difluorobenzoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-(1-methylcyclopentyl)acetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(3,3-difluoro-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(3,3,4,4-tetrafluoropentanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2,2-difluoro-3-methylbutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((R)-2-hydroxy-2-phenylacetyl)-6,6-dimethyl-N-((R)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((R)-2-(trifluoromethoxy)butanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(3-hydroxy-3-methylbutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((1R,2R)-2-(trifluoromethyl)cyclopropane-1-carbonyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-2-hydroxy-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; (6S)-5-(3,3-difluorocyclopentane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(3,3-difluorocyclobutane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(Cyclopentanecarbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (2S,4R)-1-acetyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-4-(trifluoromethyl)pyrrolidine-2-carboxamide; (S)-5-((E)-4-methylpent-2-enoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((2R,3S)-2,3-dihydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R)-2-hydroxy-4-methylpentanoyl)-N-((R)-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((S)-2-hydroxy-4-methylpentanoyl)-N-((R)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((S)-2-hydroxy-4-methylpentanoyl)-N-((R)-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((S)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(pentanoyl-d9)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(hexanoyl-d11)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(4-(methyl-d3)pentanoyl-2,2,3,3,4,5,5,5-d8)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-fluoro-2-methylpropanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(butanoyl-d7)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(3-(methyl-d3)butanoyl-2,2,3,4,4,4-d6)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-methylpropanoyl-2-d)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-(methyl-d3)propanoyl-3,3,3-d3)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(hexanoyl-2,2-d2)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((R)-2-(2-fluoro-3-methoxyphenyl)-2-hydroxyacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; N1-((S)-1-(((S)-4-hydroxy-3-oxo-1-((S)-2-oxopiperidin-3-yl)butan-2-yl)amino)-4,4-dimethyl-1-oxopentan-2-yl)-N2-(6-(trifluoromethyl)pyridin-2-yl)oxalamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(5,5,5-trifluoro-2-oxo-4-(trifluoromethyl)pentanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((R)-5,5,5-trifluoro-2-hydroxy-4-(trifluoromethyl)pentanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((S)-5,5,5-trifluoro-2-hydroxy-4-(trifluoromethyl)pentanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-(cyclopropylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-(isopropylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((S)-2,4-dimethylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-(ethylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (R)-5-(4,4-difluoropentanoyl)-N-((R)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-4,4-difluoro-1-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pyrrolidine-2-carboxamide; (S)-5-((R)-2,4-dimethylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (2S,4R)-1-((R)-2-hydroxy-4-methylpentanoyl)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pyrrolidine-2-carboxamide; (S)-5-((R)-4-fluoro-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(hexanoyl-5,5,6,6,6-d5)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (6S)-5-(2,2-difluoro-3-hydroxybutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(hexanoyl-6,6,6-d3)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (6S)-5-(2-methoxybutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(acetyl-d3)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R)-2-cyclobutyl-2-hydroxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (2S,4S)-1-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-4-phenylpyrrolidine-2-carboxamide; (6S)-5-(3-fluoro-2-hydroxy-3-methylbutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(pentanoyl-5,5,5-d3)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(butanoyl-4,4,4-d3)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-4-methyl-2-((1-methyl-1H-indole)-5-sulfonamido)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)pentanamide; (S)-5-((R)-2-hydroxypentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (R)-2-hydroxy-4-methyl-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)pentanamide; 1-((S)-2-hydroxy-2-phenylacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)azepane-2-carboxamide; 1-((S)-2-hydroxy-2-phenylacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)piperidine-2-carboxamide; 6-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-6-azaspiro[3.4]octane-7-carboxamide; (2S)-4-(bicyclo[1.1.1]pentan-2-yl)-1-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pyrrolidine-2-carboxamide; (2S,4S)-4-(cyclobutylmethyl)-1-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pyrrolidine-2-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(2-(4-(trifluoromethoxy)phenoxy)acetyl)-5-azaspiro[2.4]heptane-6-carboxamide; (6S)-5-(4-methyl-2-nitrosopentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (2S,4R)-1-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-4-(trifluoromethyl)pyrrolidine-2-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(1H-pyrrolo[2,3-b]pyridine-2-carbonyl)-5-azaspiro[2.4]heptane-6-carboxamide; 2-((4-fluorophenyl)amino)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)acetamide; (2S,4S)-1-(2-fluoro-2-methylpropanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-4-phenylpyrrolidine-2-carboxamide; (S)-5-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopiperidin-3-yl)-4-(perfluorophenoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (2S,4S)-1-((S)-2-hydroxy-2-phenylacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-4-phenylpyrrolidine-2-carboxamide; (S)-5-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopiperidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopiperidin-3-yl)-4-(2,3,6-trifluorophenoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-(6-chlorobenzo[d]isoxazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; 4-fluoro-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-1H-indole-2-carboxamide; (2S,4R)-1-((S)-2-hydroxy-2-phenylacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-4-(trifluoromethyl)pyrrolidine-2-carboxamide; (2S,4S)-1-((R)-2-hydroxy-2-phenylacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-4-phenylpyrrolidine-2-carboxamide; (S)-1-((R)-2-hydroxy-4-methylpentanoyl)-5,5-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pyrrolidine-2-carboxamide; N1-(2-fluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-((2-(trifluoromethyl)pyrimidin-4-yl)oxy)butan-2-yl)amino)pentan-2-yl)oxalamide; and N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-5-oxaspiro[2.4]heptane-6-carboxamide or a pharmaceutically acceptable salt thereof.

[0120] Specific examples of compounds of formula (III) or pharmaceutically acceptable salts thereof constitute additional embodiments of the present disclosure. In some embodiments, the compound of formula (III) is selected from the group consisting of:

[0121] (R)-N4-(2-fluorobenzyl)-2-isobutyl-N1-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)succinimide; (R)-N4-(2,6-difluorobenzyl)-2-isobutyl-N1-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)succinimide; (R)-2-Isobutyl-N1-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)-N4-phenylsuccinamide; (5R,6R)-N5-Isobutyl-N6-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)spiro[2.4]heptane-5,6-dicarboxamide; N1-(2-fluorophenyl)-N2-((S)-3-methyl-1-(1-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)-1H-1,2,3-triazol-4-yl)butyl)oxalamide; 1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N-(o-tolyl)-1H-1,2,3-triazole-4-carboxamide; N-(tert-butyl)-1-(4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1H-1,2,3-triazole-4-carboxamide; (S)-4-methyl-2-((1-methyl-1H-indole)-5-sulfonamido)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; (S)-4-methyl-2-((2-oxo-1,2-dihydroquinolin-3-yl)amino)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; (S)-4-methyl-2-((1-methyl-1H-indole)-5-sulfonamido)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)pentanamide; and 2-((4-fluorophenyl)amino)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)acetamide, or a pharmaceutically acceptable salt thereof.

[0122] In some embodiments, the compound or a pharmaceutically acceptable salt thereof may exhibit an EC value (e.g., in Hela cells) of less than 0.05 μM. For example, the compound may be selected from the group consisting of:

[0123] N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-1H-indole-2-carboxamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-1H-indole-2-carboxamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-phenyloxalamide; N1-(2-fluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide; N1-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)-N2-phenyloxalamide; N1-((S)-3-cyclobutyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)-N2-phenyloxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-(2-(trifluoromethyl)phenyl)oxalamide; N1-(2-(tert-butyl)phenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-3-cyclohexyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)-N2-phenyloxalamide; N1-((S)-5-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)hexan-2-yl)-N2-phenyloxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-(o-tolyl)oxalamide; N1-(4-fluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; (S)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)-2-(2-(phenylamino)acetamido)pentanamide; N1-((S)-3-cyclopentyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)-N2-phenyloxalamide; N1-(2-chlorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2,6-difluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-(2-(trifluoromethyl)pyridin-3-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-(naphthalen-1-yl)oxalamide; N1-((S)-3-cyclohexyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)-N2-(2-fluorophenyl)oxalamide; N1-(2-(difluoromethoxy)phenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2-ethylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2,6-dimethylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2,3-dimethylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2-fluoro-4-methylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(4-chloro-2-methylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2,4-difluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2-fluoro-6-methylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(5-fluoro-2-methylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2-fluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2-isopropylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(3-fluoro-2-methylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2-chlorophenyl)-N2-((S)-3-cyclohexyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)oxalamide; N1-((S)-3-cyclohexyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)-N2-(o-tolyl)oxalamide; N1-((S)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)-3-phenylpropan-2-yl)-N2-(o-tolyl)oxalamide; N1-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)-N2-(2-fluorophenyl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-(2-(trifluoromethoxy)phenyl)oxalamide; N1-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)-N2-(o-tolyl)oxalamide; N1-(2-(tert-butyl)phenyl)-N2-((S)-3-cyclohexyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)oxalamide; N1-(3-methoxyphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(4-methoxyphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-phenyloxalamide; (S)-3-((S)-2-(2-((2-fluorophenyl)amino)-2-oxoacetamido)-4-methylpentanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butyl diphenylphosphinate; N1-(2-fluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopiperidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4,4-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-(2-fluorophenyl)oxalamide; N1-(2-chlorophenyl)-N2-(1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)-3-(tetrahydro-2H-pyran-4-yl)propan-2-yl)oxalamide; N1-((S)-1-(((S)-7-amino-2-oxo-1-(2,3,5,6-tetrafluorophenoxy)heptan-3-yl)amino)-4-methyl-1-oxopentan-2-yl)-N2-(2-fluorophenyl)oxalamide; N1-(2,6-dimethylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; 2,2-Difluoro-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)benzo[d][1,3]dioxole-5-carboxamide; (S)-2-(2-(5-acetyl-2-methoxyphenyl)acetamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)pentanamide; N1-((S)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)-3-(pyridin-2-yl)propan-2-yl)-N2-(o-tolyl)oxalamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1H-benzo[d]imidazole-2-carboxamide; 4-Methoxy-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1H-indole-2-carboxamide; N1-(2,6-diisopropylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-5-(2-fluorophenyl)isoxazole-3-carboxamide; N-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-5-fluoro-1H-indole-2-carboxamide; N1-cyclohexyl-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2,6-dimethoxyphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2-methoxy-6-methylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2-fluoro-6-methoxyphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2,6-diethylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2,2-difluorocyclohexyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2,6-diisopropoxyphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; 5-(2-fluorophenyl)-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)isoxazole-3-carboxamide; N1-(tert-butyl)-N2-((S)-4,4-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2-(tert-butyl)phenyl)-N2-((S)-4,4-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide N1-cyclopropyl-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(3,3-difluorocyclobutyl)oxalamide; N1-(2-(methoxymethyl)phenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide N1-(3,3-difluorocyclobutyl)-N2-((S)-4,4-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(tert-butyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(3,3-difluorocyclobutyl)-N2-((S)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)-3-phenylpropan-2-yl)oxalamide; 5-(2-fluorophenyl)-N-(1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)-3-(tetrahydro-2H-pyran-4-yl)propan-2-yl)isoxazole-3-carboxamide; N1-(2,6-dicyclopropylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(1-(p-tolyl)cyclopropyl)oxalamide N1-(3-methoxyphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(2,2,2-trifluoroethyl)oxalamide; N1-(bicyclo[1.1.1]pentan-1-yl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(1-methoxy-2-methylpropan-2-yl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1H-pyrrolo[2,3-b]pyridine-2-carboxamide; (2S)-2-(2-(3,4-dihydroquinolin-1(2H)-yl)-2-oxoacetamido)-4-methyl-N-((2S)-3-oxo-1-(2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; 3-chlorobenzyl ((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)carbamate; N-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)benzo[d]oxazole-2-carboxamide; N1-(3,3-difluorocyclobutyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(o-tolyl)oxalamide; (S)-2-((R)-2-hydroxy-3-phenylpropanamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; 5-(3-fluorophenyl)-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1H-imidazole-2-carboxamide; 5-(2-Methoxyphenyl)-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1H-imidazole-2-carboxamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(1,1,1-trifluoro-2-methylpropan-2-yl)oxalamide; N1-((S)-3-cyclohexyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(1,1,1-trifluoro-2-methylpropan-2-yl)oxalamide; N1-((S)-3-(3-fluorophenyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(1-methylcyclopropyl)oxalamide; N1-(1-(2-fluorophenyl)cyclopropyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(1-methylcyclopropyl)oxalamide; N1-(2-fluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopiperidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(3,3-difluoro-1-methylcyclobutyl)oxalamide; N1-cyclobutyl-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-5-phenyl-1H-imidazole-2-carboxamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-5-phenyl-1H-imidazole-2-carboxamide; N1-((S)-4,4-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(3-fluorobicyclo[1.1.1]pentan-1-yl)oxalamide; N1-((2S)-3-(2,2-difluorocyclopentyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(2-fluorophenyl)oxalamide; 4-Methoxy-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopiperidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1H-indole-2-carboxamide; (S)-2-((R)-2-((2-fluorophenyl)amino)-3-methoxypropanamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; (S)-2-((S)-2-((2-fluorophenyl)amino)-3-methoxypropanamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(1-(trifluoromethyl)cyclopropyl)oxalamide; N1-(6,6-difluorospiro[3.3]heptan-2-yl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-3-(3-fluorophenyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(3-methoxyphenyl)oxalamide; N1-(2-fluorophenyl)-N2-((S)-3-(3-fluorophenyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopiperidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(1-methylcyclopropyl)oxalamide; N1-(1,1-difluoro-2-methylpropan-2-yl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-3-(4-fluorophenyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(1-methylcyclopropyl)oxalamide; N1-(4-fluorobicyclo[2.2.2]octan-1-yl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; 5-(2-fluoropropan-2-yl)-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)isoxazole-3-carboxamide; N1-(1-(fluoromethyl)cyclopropyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; 7-Methoxy-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-2,3-dihydrobenzofuran-2-carboxamide; (1S,3aR,6aS)-2-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,2S,5S)-3-((S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,3aR,6aS)-2-((S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-5-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; N1-(2-fluorophenyl)-N2-(1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)-3-(tetrahydro-2H-pyran-4-yl)propan-2-yl)oxalamide; N-((2S)-4-methyl-1-oxo-1-(((2S)-3-oxo-1-(2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-2-(trifluoromethyl)thiazole-4-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-(5-(trifluoromethyl)isoxazole-3-carbonyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; N-((S)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)butan-2-yl)-5-oxaspiro[2.4]heptane-6-carboxamide; (R)—N-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)tetrahydrofuran-2-carboxamide; (R)-N-((S)-4,4-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)tetrahydrofuran-2-carboxamide N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-7-oxabicyclo[2.2.1]heptane-1-carboxamide; (1S,3aR,6aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(4-(trifluoromethyl)-2-oxabicyclo[2.1.1]hexane-1-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-4-(trifluoromethyl)-2-oxabicyclo[2.1.1]hexane-1-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(4-(trifluoromethyl)-2-oxabicyclo[2.1.1]hexane-1-carbonyl)-5-azaspiro[2.4]heptane-6-carboxamide; 4-(Difluoromethyl)-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-2-oxabicyclo[2.1.1]hexane-1-carboxamide; (R)-4-methyl-1-oxo-1-((S)-6-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-5-azaspiro[2.4]heptan-5-yl)pentan-2-yl tert-butylcarbamate; (R)-4-methyl-1-oxo-1-((S)-6-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-5-azaspiro[2.4]heptan-5-yl)pentan-2-yl isopropylcarbamate; (R)-4-methyl-1-oxo-1-((S)-6-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-5-azaspiro[2.4]heptan-5-yl)pentan-2-ylcyclohexylcarbamate; (R)-4-methyl-1-oxo-1-((S)-6-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-5-azaspiro[2.4]heptan-5-yl)pentan-2-ylphenylcarbamate; (S)-5-((R)-2-(difluoromethoxy)-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-((R)-2-(trifluoromethoxy)butanoyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (6S)-5-(2-methoxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((S)-2-hydroxy-3,3-dimethylbutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((S)-2-hydroxy-3,3-dimethylbutanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (6S)-5-(2-hydroxy-4,4-dimethylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide (1R,2S,5S)-3-(2-hydroxy-4,4-dimethylpentanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,3aR,6aS)-2-(2-hydroxy-4,4-dimethylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-5-((S)-2-hydroxy-4,4-dimethylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (6S)-5-(2-hydroxy-2,4-dimethylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((R)-2-hydroxy-4-methylpentanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-5-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-5-((S)-2-hydroxy-2-phenylpropanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R)-2-hydroxy-2-phenylpropanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(1-hydroxy-3,3-dimethylcyclobutane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((R)-2-hydroxypentanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,3aR,6aS)-2-((2R,3R)-2-hydroxy-3-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-5-((R)-2-methoxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((R)-2-hydroxy-2-(2-methoxyphenyl)acetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (6S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(5,5,5-trifluoro-2-hydroxy-4-(trifluoromethyl)pentanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-((R)-3-cyclopropyl-2-hydroxypropanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,2S,5S)-3-((S)-3-cyclopropyl-2-hydroxypropanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-3-(2-(3,4-difluorophenyl)-2-hydroxyacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (6S)-5-(2-(2,4-difluorophenyl)-2-hydroxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-((R)-2-(4-fluorophenyl)-2-hydroxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,2S,5S)-3-((R)-2-(2-fluorophenyl)-2-hydroxyacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-2-((R)-2-(2-fluorophenyl)-2-hydroxyacetamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; (1S,3aR,6aS)-2-((R)-2-(2-fluorophenyl)-2-hydroxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,2S,5S)-3-((S)-2-(2-fluorophenyl)-2-hydroxyacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-3-((R)-2-hydroxy-2-phenylacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,3aR,6aS)-2-((R)-2-hydroxy-2-phenylacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,2S,5S)-3-((S)-2-hydroxy-2-phenylacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,3aR,6aS)-2-((S)-2-hydroxy-2-phenylacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-5-(4,4-difluoro-1-hydroxycyclohexane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((2R,4R)-5,5,5-trifluoro-2-hydroxy-4-methylpentanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((2R,4S)-5,5,5-trifluoro-2-hydroxy-4-methylpentanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(4-methyl-2-oxopentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(2-((1-(trifluoromethyl)cyclopropyl)amino)acetamido)pentanamide; tert-butyl ((R)-1-((1R,2S,5S)-6,6-dimethyl-2-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-3-azabicyclo[3.1.0]hexan-3-yl)-1-oxobutan-2-yl)carbamate; (S)-5-((S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; Cyclopropyl ((S)-1-((1R,2S,5S)-6,6-dimethyl-2-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-3-azabicyclo[3.1.0]hexan-3-yl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate; (S)-5-(4-(tert-butyl)benzoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((R)-2-hydroxy-4,4-dimethylpentanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-5-(2-methyl-2-(3-(trifluoromethyl)phenyl)propanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(3-(trifluoromethyl)benzoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(3-(tert-butyl)benzoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(4,4-dimethylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; 5-(2-fluorophenyl)-N-((S)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)-3-phenylpropan-2-yl)isoxazole-3-carboxamide; 5-benzyl-N-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)isoxazole-3-carboxamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-5-(pyridin-2-yl)isoxazole-3-carboxamide; 7-Methoxy-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)benzofuran-2-carboxamide; (1R,2S,5S)-3-(2-(cyclohexylamino)-2-oxoacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopiperidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-(2-oxo-2-(o-tolylamino)acetyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,3aR,6aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(2-(trifluoromethyl)thiazole-4-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,2S,5S)-3-(5-(2-fluoropropan-2-yl)isoxazole-3-carbonyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-3-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; N-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-5-(2-fluoropropan-2-yl)isoxazole-3-carboxamide; (1S,3aR,6aS)-2-(5-(2-fluoropropan-2-yl)isoxazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(5-(difluoromethyl)isoxazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-5-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; N1-(tert-butyl)-N2-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)oxalamide; N1-((S)-4,4-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(o-tolyl)oxalamide; N1-((S)-4,4-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(2,2,2-trifluoroethyl)oxalamide; N1-(3-fluorobicyclo[1.1.1]pentan-1-yl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(o-tolyl)oxalamide; N1-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(3-fluorobicyclo[1.1.1]pentan-1-yl)oxalamide; (1S,3aR,6aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(2-oxo-2-(o-tolylamino)acetyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; N1-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(2,2,2-trifluoroethyl)oxalamide; (1S,3aR,6aS)-2-(2-((3,3-difluorocyclobutyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; N1-(1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)-3-(tetrahydro-2H-pyran-4-yl)propan-2-yl)-N2-(o-tolyl)oxalamide; (1S,3aR,6aS)-2-(2-((3-fluorobicyclo[1.1.1]pentan-1-yl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(2-oxo-2-((1,1,1-trifluoro-2-methylpropan-2-yl)amino)acetyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(2-oxo-2-(o-tolylamino)acetyl)-5-azaspiro[2.4]heptane-6-carboxamide; N1-((S)-4,4-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(2-fluorophenyl)oxalamide; 2-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-azaspiro[4.5]decane-3-carboxamide; 5-(Difluoromethyl)-N-((S)-4,4-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)isoxazole-3-carboxamide; N-((S)-4,4-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-2-(trifluoromethyl)thiazole-5-carboxamide; 1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N-(o-tolyl)-1H-1,2,3-triazole-4-carboxamide; (1R,2S,5S)-3-(2-((1,1-difluoro-2-methylpropan-2-yl)amino)-2-oxoacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,3aR,6aS)-2-(benzo[d]isoxazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; N1-((S)-5,5-difluoro-4,4-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(3-fluorobicyclo[1.1.1]pentan-1-yl)oxalamide; N1-((S)-3-cyclobutyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(3-fluorobicyclo[1.1.1]pentan-1-yl)oxalamide; (S)-5-(5-(difluoromethyl)isoxazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; N1-(3-fluorobicyclo[1.1.1]pentan-1-yl)-N2-((S)-3-(1-methylcyclobutyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)oxalamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(2-oxo-2-((2-(trifluoromethyl)phenyl)amino)acetyl)-5-azaspiro[2.4]heptane-6-carboxamide; N1-(1-methylcyclopropyl)-N2-(3-(1-methylcyclopropyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)oxalamide; N1-cyclopropyl-N2-(3-(1-methylcyclopropyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)oxalamide; N1-(3-fluorobicyclo[1.1.1]pentan-1-yl)-N2-((S)-3-(1-methylcyclopropyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)oxalamide; (S)-1-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)azepane-2-carboxamide; N1-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(1-methylcyclopropyl)oxalamide; N1-cyclopropyl-N2-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)oxalamide; (S)-5-(2-((4-chloro-2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(3-(trifluoromethyl)bicyclo[1.1.1]pentan-1-yl)oxalamide; (S)-5-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-4,4,6-d3-6-carboxamide; (S)-5-(2-((2,3-difluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-((2-fluoro-3-methoxyphenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-((2-fluoro-3-(trifluoromethoxy)phenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-((2,5-difluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-(5-fluoro-1H-indole-2-carbonyl)-N-((R)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-5-(4-methoxy-1H-indole-2-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-((2-chlorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-((3-chlorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(6-chlorobenzo[d]isoxazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(2-oxo-2-((2-(trifluoromethoxy)phenyl)amino)acetyl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-(6-fluorobenzo[d]isoxazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1,3,3-d3-1-carboxamide; (S)-5-(2-((2-(tert-butyl)phenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-(5-fluorobenzo[d]isoxazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(2-((2-(tert-butyl)phenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-5-(2,2-difluoro-2-phenylacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-methyl-2-phenylpropanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; benzyl ((S)-1-((1R,2S,5S)-6,6-dimethyl-2-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-3-azabicyclo[3.1.0]hexan-3-yl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate; (S)-5-(2,2-difluoro-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(2,2,4-trimethylpentanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (R)-4-methyl-1-oxo-1-((S)-6-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-5-azaspiro[2.4]heptan-5-yl)pentan-2-ylpropionate; (1R,2S,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-((S)-2-phenylpropanoyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (R)-4-methyl-1-oxo-1-((S)-6-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-5-azaspiro[2.4]heptan-5-yl)pentan-2-yl 2-phenylacetate; (S)-5-(1-hydroxy-4,4-dimethylcyclohexane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (2S,4R)-4-(tert-butyl)-1-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)piperidine-2-carboxamide; (S)-1-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)azepane-2-carboxamide; (S)-1-((R)-2-hydroxy-4-methylpentanoyl)-4,4-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)piperidine-2-carboxamide; (S)-2-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; tert-butyl ((R)-4-methyl-1-oxo-1-((S)-6-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-5-azaspiro[2.4]heptan-5-yl)pentan-2-yl)carbamate; (S)-5-(4,4-difluoro-1-methoxycyclohexane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(2-phenylacetyl)-5-azaspiro[2.4]heptane-6-carboxamide; 4-fluoro-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-1H-indole-2-carboxamide; 2-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-azaspiro[4.4]nonane-3-carboxamide; (S)-5-((R)-2-hydroxy-4,4-dimethylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-(5-chlorobenzo[d]isoxazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-5-(7-chloro-1H-indole-2-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (R)—N-((S)-3-(3-fluorophenyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-2-hydroxy-4-methylpentanamide; N1-((S)-3-(3-fluorophenyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-methyloxalamide; (S)-5-(4,4-difluoropentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (2S,4R)-1-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-4-(trifluoromethyl)pyrrolidine-2-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(2-(trifluoromethyl)benzoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2,2-difluorobenzo[d][1,3]dioxole-5-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-(3,3-difluorocyclobutyl)acetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R)-2-hydroxy-4-(methyl-13C)pentanoyl-1,2,3,4,5-13C5)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-(1-methylcyclopentyl)acetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(3,3-difluoro-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2,2-difluoro-3-methylbutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((1R,2R)-2-(trifluoromethyl)cyclopropane-1-carbonyl)-5-azaspiro[2.4]heptane-6-carboxamide; (6S)-5-(3,3-difluorocyclopentane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((E)-4-methylpent-2-enoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(pentanoyl-d9)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(hexanoyl-d11)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(4-(methyl-d3)pentanoyl-2,2,3,3,4,5,5,5-d8)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-fluoro-2-methylpropanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(butanoyl-d7)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(3-(methyl-d3)butanoyl-2,2,3,4,4,4-d6)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(hexanoyl-2,2-d2)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((R)-2-(2-fluoro-3-methoxyphenyl)-2-hydroxyacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(5,5,5-trifluoro-2-oxo-4-(trifluoromethyl)pentanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((R)-5,5,5-trifluoro-2-hydroxy-4-(trifluoromethyl)pentanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((S)-5,5,5-trifluoro-2-hydroxy-4-(trifluoromethyl)pentanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-(isopropylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R)-2,4-dimethylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (2S,4R)-1-((R)-2-hydroxy-4-methylpentanoyl)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pyrrolidine-2-carboxamide; (S)-5-(hexanoyl-5,5,6,6,6-d5)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(hexanoyl-6,6,6-d3)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (2S,4S)-1-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-4-phenylpyrrolidine-2-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(pentanoyl-5,5,5-d3)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-4-methyl-2-((1-methyl-1H-indole)-5-sulfonamido)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)pentanamide; 1-((S)-2-hydroxy-2-phenylacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)piperidine-2-carboxamide; (2S)-4-(bicyclo[1.1.1]pentan-2-yl)-1-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pyrrolidine-2-carboxamide; (2S,4S)-4-(cyclobutylmethyl)-1-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pyrrolidine-2-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(2-(4-(trifluoromethoxy)phenoxy)acetyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopiperidin-3-yl)-4-(perfluorophenoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (2S,4S)-1-((S)-2-hydroxy-2-phenylacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-4-phenylpyrrolidine-2-carboxamide; (S)-5-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopiperidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopiperidin-3-yl)-4-(2,3,6-trifluorophenoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-(6-chlorobenzo[d]isoxazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; 4-fluoro-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-1H-indole-2-carboxamide; and N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-5-oxaspiro[2.4]heptane-6-carboxamide, or a pharmaceutically acceptable salt thereof.

[0124] In some embodiments, the compound or a pharmaceutically acceptable salt thereof may exhibit an EC value (e.g., in Hela cells) of 0.05 μM to less than 0.2 μM. For example, the compound may be selected from the group consisting of:

[0125] 4-Methoxy-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-1H-indole-2-carboxamide; N-((S)-3-cyclohexyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)-1H-indole-2-carboxamide; (S)-3-((S)-2-(4-methoxy-1H-indole-2-carboxamido)-4-methylpentanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butyl 2,6-dichlorobenzoate; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)benzamide; 5-fluoro-N-((S)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)-3-phenylpropan-2-yl)-1H-indole-2-carboxamide; 5-fluoro-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-1H-indole-2-carboxamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-(naphthalen-2-yl)oxalamide; N1-(4-chlorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-phenethyloxalamide; N1-benzyl-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(3-fluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-(pyridin-2-yl)oxalamide; N1-(3-chlorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(3,4-difluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2-bromophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; (S)-2-((E)-3-(2-fluorophenyl)acrylamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)pentanamide; (S)-2-Cinnamamido-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)pentanamide; N1-cyclohexyl-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2,3-difluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2,5-difluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; (S)-3-((S)-4-methyl-2-(2-oxo-2-(phenylamino)acetamido)pentanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butyl diphenylphosphinate; N1-(2-cyanophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(3,3-difluoro-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-(2-fluorophenyl)oxalamide; N1-(5-fluoro-2-methoxyphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(cyclopentylmethyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; (S)-2-(3-(2-fluorophenyl)ureido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)pentanamide; N1-(4-bromo-3,5-difluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2-chlorophenyl)-N2-((S)-3-(4,4-difluorocyclohexyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)oxalamide; N1-(2-fluorophenyl)-N2-((S)-3-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)butan-2-yl)oxalamide; N1-(3,3-difluorocyclohexyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(4-bromo-2-fluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-cyclopropyl-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-(1-methylcyclopropyl)oxalamide; N1-(tert-butyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-(tetrahydro-2H-pyran-4-yl)oxalamide; N1-cyclopentyl-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-((S)-tetrahydro-2H-pyran-3-yl)oxalamide; N1-(2-benzylphenyl)-N2-((S)-3-cyclohexyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)oxalamide; N1-(2-methoxyphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-1-(((S)-6-(dimethylamino)-2,6-dioxo-1-(2,3,5,6-tetrafluorophenoxy)hexan-3-yl)amino)-4-methyl-1-oxopentan-2-yl)-N2-(2-fluorophenyl)oxalamide; N1-cyclobutyl-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2-fluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,6-trifluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-((R)-tetrahydro-2H-pyran-3-yl)oxalamide; N1-(2-(methoxymethyl)phenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; (S)-2-((R)-2-(3-chlorophenyl)-2-hydroxyacetamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)pentanamide; N1-((S)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)-3-(pyridin-2-yl)propan-2-yl)-N2-(o-tolyl)oxalamide; (S)-2-(2-(3,4-dihydroquinolin-1(2H)-yl)-2-oxoacetamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)pentanamide; N1-(4,4-difluorocyclohexyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)benzo[d][1,3]dioxole-5-carboxamide; N-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-5-(4-fluorophenyl)-1,3,4-oxadiazole-2-carboxamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; N-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-3-phenyl-1H-pyrazole-5-carboxamide; (3S)-3-((S)-2-(4-methoxy-1H-indole-2-carboxamido)-4-methylpentanamido)-2-oxo-4-(2-oxopyrrolidin-3-yl)butyl diphenylphosphinate; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)imidazo[1,2-a]pyridine-2-carboxamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)imidazo[1,2-b]pyridazine-2-carboxamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)indoline-2-carboxamide; 2-methyl-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)tetrahydrofuran-2-carboxamide; N1-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(4-methyltetrahydro-2H-pyran-4-yl)oxalamide; (R)—N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)tetrahydrofuran-2-carboxamide; 4-Methoxy-N-((S)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)-5-phenylpentan-2-yl)-1H-indole-2-carboxamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(2-oxaspiro[3.3]heptan-6-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(oxetan-3-yl)oxalamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1,4-dioxane-2-carboxamide; N1-(1-(methoxymethyl)cyclopropyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; (1R,3S,5R)-2-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-azabicyclo[3.1.0]hexane-3-carboxamide; (1S,3aR,6aS)-2-(2-((1-methylcyclopropyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-((R)-tetrahydrofuran-2-carbonyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,3aR,6aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(5-oxaspiro[2.4]heptane-6-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-((R)-tetrahydrofuran-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)—N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)tetrahydrofuran-2-carboxamide; (1R,2S,5S)-3-((R)-1,4-dioxane-2-carbonyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,3aR,6aS)-2-(7-oxabicyclo[2.2.1]heptane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(4-methyl-2-oxabicyclo[2.1.1]hexane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; 4-methyl-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-2-oxabicyclo[2.1.1]hexane-1-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-(4-(trifluoromethyl)-2-oxabicyclo[2.1.1]hexane-1-carbonyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,3aR,6aS)-2-(4-(difluoromethyl)-2-oxabicyclo[2.1.1]hexane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,2S,5S)-3-(4-(difluoromethyl)-2-oxabicyclo[2.1.1]hexane-1-carbonyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,3aR,6aS)-2-(3,3-difluorotetrahydrofuran-2-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; 3,3-difluoro-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)tetrahydrofuran-2-carboxamide; (S)-5-((R)-2-(2-hydroxy-2-methylpropoxy)-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((R)-2-methoxybutanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-2-((R)-2-methoxybutanamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; (S)-5-((S)-2-methoxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-2-((R)-2-hydroxy-3,3-dimethylbutanamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; (S)-5-((R)-2-hydroxy-3,3-dimethylbutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((R)-2-hydroxy-3,3-dimethylbutanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-5-((S)-4-fluoro-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-(2-hydroxy-2-methylpropanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,3aR,6aS)-2-(2-hydroxy-2-methylpropanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-2-(2-hydroxy-2-methylpropanamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; (S)-5-(2-hydroxy-2-methylpropanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-2-((R)-2-hydroxy-3-methylbutanamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; (S)-5-((R)-2-hydroxy-3-methylbutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((R)-2-hydroxy-3-methylbutanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-5-((S)-2-hydroxy-3-methylbutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-((R)-2-hydroxy-3-methylbutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,2S,5S)-3-((R)-2-hydroxybutanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-2-((R)-2-hydroxybutanamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; (1R,2S,5S)-3-((S)-2-hydroxybutanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-5-((R)-2-hydroxybutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (R)-2-hydroxy-N-((R)-3-(1-methylcyclopropyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)butanamide; (1S,3aR,6aS)-2-((R)-2-hydroxybutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-5-((2R,3R)-2-hydroxy-3-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-((S)-3,3,3-trifluoro-2-hydroxypropanamido)pentanamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((S)-3,3,3-trifluoro-2-hydroxypropanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-((S)-3,3,3-trifluoro-2-hydroxypropanoyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((R)-3,3,3-trifluoro-2-hydroxypropanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (6S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(4,4,4-trifluoro-2-hydroxybutanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-(4,4,4-trifluoro-2-hydroxybutanoyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-5-((R)-3-cyclopropyl-2-hydroxypropanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (6S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(5,5,5-trifluoro-2-hydroxypentanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((S)-3-fluoro-2-hydroxypropanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R)-2-hydroxy-3-phenylpropanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (6S)-5-(2-hydroxy-2-(3,4,5-trifluorophenyl)acetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (6S)-5-(2-(3,4-difluorophenyl)-2-hydroxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R)-2-(4-fluorophenyl)-2-hydroxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (6S)-5-(2-(3-fluorophenyl)-2-hydroxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (6S)-5-(2-hydroxy-2-(2-(trifluoromethyl)phenyl)acetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R)-2-(2-fluorophenyl)-2-hydroxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R)-2-hydroxy-2-phenylacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((S)-2-hydroxy-2-phenylacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (6S)-5-(2-hydroxy-2-(pyridin-2-yl)acetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(1-hydroxycyclopropane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(1-hydroxycyclobutane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(1-hydroxycyclopentane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(1-hydroxycyclohexane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-((R)-2-hydroxypentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-5-((R)-3-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((S)-3-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; Methyl ((S)-3,3-dimethyl-1-oxo-1-((S)-6-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-5-azaspiro[2.4]heptan-5-yl)butan-2-yl)carbamate; (S)-5-((2-fluorobenzoyl)glycyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((S)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-ethylbutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,3S,5R)-2-((R)-2-hydroxy-4-methylpentanoyl)-5-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-azabicyclo[3.1.0]hexane-3-carboxamide; (S)-5-((R)-4,4-difluoro-2-hydroxybutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,3S,5R)-2-((R)-2-hydroxy-3-methylbutanoyl)-5-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-azabicyclo[3.1.0]hexane-3-carboxamide; (S)-5-(2-(3-(tert-butyl)phenyl)-2-methylpropanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-(2-(trifluoromethyl)thiazole-4-carbonyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-6,6-dimethyl-3-(2-((1-methylcyclopropyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-3-(2-(tert-butylamino)-2-oxoacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(2-oxo-2-((1,1,1-trifluoro-2-methylpropan-2-yl)amino)acetyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-(2-oxo-2-((1-(trifluoromethyl)cyclopropyl)amino)acetyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-3-(2-((3,3-difluorocyclobutyl)amino)-2-oxoacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (6S)-1,1-difluoro-5-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(5-(trifluoromethyl)isoxazole-3-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,2S,5S)-3-(2-((2,2-difluoropropyl)amino)-2-oxoacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-3-(2-((3-fluorobicyclo[1.1.1]pentan-1-yl)amino)-2-oxoacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (3S,4aS,8aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(2-oxo-2-((1,1,1-trifluoro-2-methylpropan-2-yl)amino)acetyl)decahydroisoquinoline-3-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-(3-(trifluoromethyl)isoxazole-5-carbonyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((R)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-(3-(trifluoromethyl)isoxazole-5-carbonyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,3aR,6aS)-2-(2-(tert-butylamino)-2-oxoacetyl)-N-((R)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(2-(cyclopropylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (2S,3aS,7aS)-1-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydro-1H-indole-2-carboxamide; 5-(2-fluoropropan-2-yl)-N-(1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)-3-(tetrahydro-2H-pyran-4-yl)propan-2-yl)isoxazole-3-carboxamide; 6-(2-(tert-butylamino)-2-oxoacetyl)-2,2-difluoro-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-6-azaspiro[3.4]octane-7-carboxamide; 6-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-6-azaspiro[3.4]octane-7-carboxamide; N1-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(1-(trifluoromethyl)cyclopropyl)oxalamide; (1R,2S,5S)-3-(2-((2,2-difluoroethyl)amino)-2-oxoacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (3R,6S)-5-(2-(tert-butylamino)-2-oxoacetyl)-1,1-difluoro-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-(2-(tert-butylamino)-2-oxoacetyl)-5,5-difluoro-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; N1-(tert-butyl)-N2-((S)-1-cyclopentyl-2-oxo-2-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)ethyl)-N2-methyloxalamide; (1S,3aR,6aS)-2-(2-((1-methyl-1H-pyrazol-3-yl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,2S,5S)-6,6-dimethyl-3-(2-((1-methyl-1H-pyrazol-3-yl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-3-(2-((3,3-difluorocyclobutyl)amino)-2-oxoacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,3S,5S)-2-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-azabicyclo[3.1.0]hexane-3-carboxamide; (1R,3S,4S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(2-oxo-2-((2,2,2-trifluoroethyl)amino)acetyl)-2-azabicyclo[2.2.1]heptane-3-carboxamide; (1S,3aR,6aS)-2-(5-methylisoxazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(6,7-dihydro-4H-pyrano[3,4-d]isoxazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,2S,5S)-3-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azaspiro[bicyclo[3.1.0]hexane-6,1′-cyclopropane]-2-carboxamide; (1S,3aR,6aS)-2-(2-((1,1-difluoro-2-methylpropan-2-yl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; Tetrahydrofuran-3-yl(1S,3aR,6aS)-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)hexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate; (1S,2S,5R)-3-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.2.0]heptane-2-carboxamide; (1S,3aR,6aS)-2-(2-((2-cyanopropan-2-yl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-5-(5,5-dimethyl-4,5,6,7-tetrahydrobenzo[d]isoxazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(2-oxo-2-((2,2,2-trifluoroethyl)amino)acetyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-((1-methylcyclopropyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-1-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)azetidine-2-carboxamide; N1-((S)-3-(3,4-difluorophenyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(2-fluorophenyl)oxalamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(2-oxo-2-((1,1,1-trifluoro-2-methylpropan-2-yl)amino)acetyl)-5-azaspiro[2.4]heptane-6-carboxamide; N-(tert-butyl)-1-(4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1H-1,2,3-triazole-4-carboxamide; (1R,2S,5S)-3-(3,5-difluoro-2-hydroxybenzoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-5-((S)-3-hydroxy-2-phenylpropanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-(2-(tert-butylamino)-2-oxoacetyl)-4-fluoro-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-5-(2-((2-chloro-6-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-pentanoyl-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-(2-(6-chloropyrazin-2-yl)-2-methoxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (R)-1-(2-fluorophenyl)-2-oxo-2-((1S,3aR,6aS)-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethyl 2-phenylacetate; (S)-5-(4-fluoro-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(3-fluorobicyclo[1.1.1]pentane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((S)-2-phenylpropanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-(4,4-difluoro-1-hydroxycyclohexane-1-carbonyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-5-(2,2-difluoroacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-1-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)piperidine-2-carboxamide; (1R,2S,5S)-3-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.2.1]octane-2-carboxamide; (S)-6-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-6-azaspiro[2.5]octane-5-carboxamide; tert-butyl methyl ((R)-4-methyl-1-oxo-1-((S)-6-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-5-azaspiro[2.4]heptan-5-yl)pentan-2-yl)carbamate; (S)-5-(2-isopropoxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(1-hydroxy-4-(trifluoromethyl)cyclohexane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-3-((S)-2-(2-((2-fluorophenyl)amino)-2-oxoacetamido)-4-methylpentanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butylmethyl(phenyl)phosphinate; (1S,3aR,6aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(2-oxo-2-((1-(trifluoromethyl)cyclopropyl)amino)acetyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-5-(methyl-D-leucyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(4,4-difluorocyclohexane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R)-2-hydroxypent-4-enoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-acetyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-pivaloyl-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R,E)-2-hydroxy-5-(4-methoxyphenyl)pent-4-enoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R,E)-5-(4-fluorophenyl)-2-hydroxypent-4-enoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R)-2-hydroxy-4-methylpentanoyl)-N-((R)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((N-phenylsulfamoyl)glycyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((2,2,2-trifluoroethyl)glycyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(2-(2,2,2-trifluoroethoxy)acetyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(2-oxo-2-phenylacetyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-(methylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (6S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(3,3,3-trifluoro-2-hydroxy-2-phenylpropanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(4,4-difluorobutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(3,3,4,4-tetrafluorobutanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-propionyl-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(but-3-enoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(pent-4-enoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-Benzoyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(1-isobutyl-1H-1,2,3-triazole-4-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-1-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pyrrolidine-2-carboxamide; (S)-5-((R)-2-hydroxypropanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-hydroxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(3,5-difluorobenzoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((S)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(4-chloro-2-fluorobenzoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-Isobutyryl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(3-methylbutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-Hexanoyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(3,3,4,4-tetrafluoropentanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((R)-2-hydroxy-2-phenylacetyl)-6,6-dimethyl-N-((R)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((R)-2-(trifluoromethoxy)butanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(3-hydroxy-3-methylbutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(3,3-difluorocyclobutane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(Cyclopentanecarbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (2S,4R)-1-acetyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-4-(trifluoromethyl)pyrrolidine-2-carboxamide; (S)-5-((R)-2-hydroxy-4-methylpentanoyl)-N-((R)-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((S)-2-hydroxy-4-methylpentanoyl)-N-((R)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((S)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-methylpropanoyl-2-d)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-(methyl-d3)propanoyl-3,3,3-d3)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-(cyclopropylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((S)-2,4-dimethylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-(ethylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (R)-5-(4,4-difluoropentanoyl)-N-((R)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-4,4-difluoro-1-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pyrrolidine-2-carboxamide; (S)-5-((R)-4-fluoro-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (6S)-5-(2,2-difluoro-3-hydroxybutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R)-2-cyclobutyl-2-hydroxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (6S)-5-(3-fluoro-2-hydroxy-3-methylbutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(butanoyl-4,4,4-d3)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R)-2-hydroxypentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; 1-((S)-2-hydroxy-2-phenylacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)azepane-2-carboxamide; 6-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-6-azaspiro[3.4]octane-7-carboxamide; (2S,4R)-1-((S)-2-hydroxy-2-phenylacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-4-(trifluoromethyl)pyrrolidine-2-carboxamide; (2S,4S)-1-((R)-2-hydroxy-2-phenylacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-4-phenylpyrrolidine-2-carboxamide; (S)-1-((R)-2-hydroxy-4-methylpentanoyl)-5,5-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pyrrolidine-2-carboxamide or a pharmaceutically acceptable salt thereof.

[0126] In some embodiments, the compound or a pharmaceutically acceptable salt thereof may exhibit an EC value (e.g., in Hela cells) of 0.2 μM to less than 0.5 μM. For example, the compound may be selected from the group consisting of:

[0127] (S)-3-((S)-2-(4-methoxy-1H-indole-2-carboxamido)-4-methylpentanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butyl 2,6-dichlorobenzoate; N-((S)-1-(((S)-4-(2,6-difluorophenoxy)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide; 5-fluoro-N-((S)-5-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)hexan-2-yl)-1H-indole-2-carboxamide; benzyl ((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)carbamate; 5-fluoro-N-((S)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)-3-(4-(trifluoromethyl)phenyl)propan-2-yl)-1H-indole-2-carboxamide; 5-fluoro-N-((2S)-3-(4-methoxyphenyl)-1-oxo-1-(((2S)-3-oxo-1-(2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)-1H-indole-2-carboxamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)quinoline-2-carboxamide; 3-chlorobenzyl ((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)carbamate; 4-Fluorobenzyl ((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)carbamate; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)benzo[d][1,3]dioxole-5-carboxamide; (R)—N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)tetrahydrofuran-2-carboxamide; (S)-3-((S)-2-(5-fluoro-1H-indole-2-carboxamido)-4-methylpentanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butyl diphenylphosphinate; N1-(2-benzylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pent-4-en-2-yl)-N2-phenyloxalamide; N1-(2,5-dichlorobenzyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; 5-(2-fluorophenyl)-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)isoxazole-3-carboxamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-5-phenylisoxazole-3-carboxamide; N1-(4-fluoro-2-methylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; (2S)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)-2-(3,3,3-trifluoro-2-((2-fluorophenyl)amino)propanamido)pentanamide; N1-methyl-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N1-(o-tolyl)oxalamide; N1-((S)-4-cyclohexyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)butan-2-yl)-N2-(2-fluorophenyl)oxalamide; N-((S)-3-cyclohexyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)-5-(2-fluorophenyl)isoxazole-3-carboxamide; 5-methyl-N-((S)-3-methyl-1-(((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)amino)-1-oxobutan-2-yl)isoxazole-3-carboxamide; N-((S)-3,3-dimethyl-1-(((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)amino)-1-oxobutan-2-yl)-5-methylisoxazole-3-carboxamide; N1-((S)-3,3-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)butan-2-yl)-N2-(2-fluorophenyl)oxalamide; N1-(2-fluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,4,6-trifluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-((S)-1,2,3,4-tetrahydronaphthalen-1-yl)oxalamide; (3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)carbamate; N1-(tert-butyl)-N2-(1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)-3-(tetrahydro-2H-pyran-4-yl)propan-2-yl)oxalamide; N-((S)-1-(((S)-4-(difluoromethoxy)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide; N1-(2-fluorophenyl)-N2-((S)-1-(((S)-6-guanidino-2-oxo-1-(2,3,5,6-tetrafluorophenoxy)hexan-3-yl)amino)-4-methyl-1-oxopentan-2-yl)oxalamide; N1-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(3-(methoxymethyl)oxetan-3-yl)oxalamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1H-pyrrolo[3,2-b]pyridine-2-carboxamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(3-methylpyrrolidin-3-yl)oxalamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1H-pyrrolo[3,2-b]pyridine-3-carboxamide; (1S,3aR,6aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(1-(2,2,2-trifluoroacetamido)cyclobutane-1-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,2S,5S)-3-((S)-3,3-dimethyl-2-((R)-tetrahydrofuran-2-carboxamido)butanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((R)-tetrahydrofuran-2-carbonyl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((S)-1,4-dioxane-2-carbonyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (6S)-5-(2-methyltetrahydrofuran-2-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-4-(2,2,2-trifluoroacetamido)-2-oxabicyclo[2.1.1]hexane-1-carboxamide; (S)-5-(4-(difluoromethyl)-2-oxabicyclo[2.1.1]hexane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2,2-dimethoxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (2R)-2-hydroxy-N-(3-(1-methylcyclopropyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)butanamide; (2S,3aS,7aS)-1-((R)-2-hydroxybutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydro-1H-indole-2-carboxamide; (S)-2-((S)-3-fluoro-2-hydroxypropanamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; (S)-5-(4-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((methylcarbamoyl)-D-leucyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((R)-2-aminobutanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-3-(3-(4,4-difluoropiperidin-1-yl)-2-(2,2,2-trifluoroacetamido)propanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; N-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-5-(phenylamino)-1,3,4-oxadiazole-2-carboxamide; (S)-4-methyl-2-((1-methyl-1H-indole)-5-sulfonamido)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; (S)-4-methyl-2-((2-oxo-1,2-dihydroquinolin-3-yl)amino)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; (1S,2S,5R)-3-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; N1-(3-fluorobicyclo[1.1.1]pentan-1-yl)-N2-(1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)-3-(tetrahydro-2H-pyran-4-yl)propan-2-yl)oxalamide; (1S,3aR,6aS)-2-(2-((2,2-difluoroethyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3S,5R)-2-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-azabicyclo[3.1.0]hexane-3-carboxamide; (1S,3S,4R)-2-(2-((1-methylcyclopropyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-azabicyclo[2.2.1]heptane-3-carboxamide; (1S,3aR,6aS)-2-(2-(((1R,5S,6r)-3-oxabicyclo[3.1.0]hexan-6-yl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,2S,5R)-3-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.2.0]heptane-2-carboxamide; (R)-1-(2-(tert-butylamino)-2-oxoacetyl)-2-(cyclopropylmethyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pyrrolidine-2-carboxamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1,2,4-oxadiazole-3-carboxamide; (S)-5-(2-((3,3-difluorocyclobutyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(3-fluoropicolinoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (R)-4-methyl-1-oxo-1-((S)-6-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-5-azaspiro[2.4]heptan-5-yl)pentan-2-yl isobutyrate; (S)-5-(D-leucyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-3-((S)-4-methyl-2-(2-oxo-2-(phenylamino)acetamido)pentanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butylmethyl(phenyl)phosphinate; (1R,2S,5S)-3-(5-(2-fluoropropan-2-yl)isoxazole-3-carbonyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(3-((N-phenylsulfamoyl)amino)propanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R,E)-2-hydroxy-6-(methylsulfonamido)hex-4-enoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((S)-tetrahydrofuran-2-carbonyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(4,4-difluoro-1-(2,2,2-trifluoroacetamido)cyclohexane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(tetrahydro-2H-pyran-4-carbonyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((N,N-dimethylsulfamoyl)glycyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(N-(N,N-dimethylsulfamoyl)-N-methylglycyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(2,2,2-trifluoroacetyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-Butyryl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-2-acetamido-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; (S)-5-(2,4-difluorobenzoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((2R,3S)-2,3-dihydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((S)-2-hydroxy-4-methylpentanoyl)-N-((R)-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; N1-((S)-1-(((S)-4-hydroxy-3-oxo-1-((S)-2-oxopiperidin-3-yl)butan-2-yl)amino)-4,4-dimethyl-1-oxopentan-2-yl)-N2-(6-(trifluoromethyl)pyridin-2-yl)oxalamide; (6S)-5-(2-methoxybutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(acetyl-d3)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (R)-2-hydroxy-4-methyl-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)pentanamide; and N1-(2-fluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-((2-(trifluoromethyl)pyrimidin-4-yl)oxy)butan-2-yl)amino)pentan-2-yl)oxalamide, or a pharmaceutically acceptable salt thereof.

[0128] In some embodiments, the compound or a pharmaceutically acceptable salt thereof may exhibit an EC value (e.g., in Hela cells) of 0.5 μM to 1 μM. For example, the compound may be selected from the group consisting of:

[0129] N-((S)-1-(((S)-4-(2,6-difluorophenoxy)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide; 5-fluoro-N-((S)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)-4-phenylbutan-2-yl)-1H-indole-2-carboxamide; N-((S)-4,4-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-5-fluoro-1H-indole-2-carboxamide; 5-fluoro-N-((S)-4-fluoro-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-1H-indole-2-carboxamide; 1-(Cyclopentanecarbonyl)-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)piperidine-4-carboxamide; (S)-1-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)pyrrolidine-2-carboxamide; 5-methyl-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)isoxazole-3-carboxamide; (S)-Tetrahydrofuran-3-yl((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)carbamate; N1-((S)-1-(((S)-1-(1H-imidazol-5-yl)-3-oxo-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-N2-(2-fluorophenyl)oxalamide; N1-((S)-1-(((R)-1-(1H-imidazol-5-yl)-3-oxo-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-N2-(2-fluorophenyl)oxalamide; Cyclopentyl methyl ((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)carbamate; N1-(2-fluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-((5-(trifluoromethyl)isoxazol-3-yl)oxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-((R)-1,2,3,4-tetrahydronaphthalen-1-yl)oxalamide; N1-(2-fluorophenyl)-N2-((S)-3-methyl-1-(1-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)-1H-1,2,3-triazol-4-yl)butyl)oxalamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-5-oxotetrahydrofuran-2-carboxamide; N1-(2-fluorophenyl)-N2-((2S)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)-3-(2-oxopyrrolidin-3-yl)propan-2-yl)oxalamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)tetrahydrofuran-3-carboxamide; N1-(1-(hydroxymethyl)cyclopropyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N-((1R,2R)-2-ethyl-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)cyclopropyl)-5-fluoro-1H-indole-2-carboxamide; N1-(1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)-3-(tetrahydro-2H-pyran-4-yl)propan-2-yl)-N2-(2,2,2-trifluoroethyl)oxalamide; (2R)—N-(1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)-3-(tetrahydro-2H-pyran-4-yl)propan-2-yl)tetrahydrofuran-2-carboxamide; (R)-3,3-dimethyl-1-oxo-1-((S)-6-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-5-azaspiro[2.4]heptan-5-yl)butan-2-yl tert-butylcarbamate; (R)-3,3-dimethyl-1-oxo-1-((S)-6-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-5-azaspiro[2.4]heptan-5-yl)butan-2-ylethylcarbamate; (2S,3aS,6aS)-1-((R)-2-hydroxybutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[b]pyrrole-2-carboxamide; (6S)-5-(2-hydroxy-2-(pyridin-3-yl)acetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-(methylprolyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(2-(cyclohexylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (R)-6-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-oxa-6-azaspiro[3.4]octane-7-carboxamide; 2-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-8-oxa-2-azaspiro[4.5]decane-3-carboxamide; 2-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-8-oxa-2-azaspiro[4.5]decane-3-carboxamide; (1S,3aR,6aS)-2-(1-methyl-1H-pyrazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-1-(2-((3,3-difluorocyclobutyl)amino)-2-oxoacetyl)-4,4-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pyrrolidine-2-carboxamide; (1S,3aR,6aS)-2-(2-morpholino-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-(2-oxo-1,2-dihydropyridin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-5-(2-((2-methoxyphenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (R)-5-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; N1-(2-fluorophenyl)-N2-((S)-4-methyl-1-(((S)-5-(methylthio)-2-oxo-1-(2,3,5,6-tetrafluorophenoxy)pentan-3-yl)amino)-1-oxopentan-2-yl)oxalamide; N1-(2-fluorophenyl)-N2-((S)-4-methyl-1-(((S)-5-(methylsulfonyl)-2-oxo-1-(2,3,5,6-tetrafluorophenoxy)pentan-3-yl)amino)-1-oxopentan-2-yl)oxalamide; (S)-5-((N-methylsulfamoyl)glycyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; and (S)-2-hydroxy-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide, or a pharmaceutically acceptable salt thereof.

[0130] Pharmaceutical compositions and uses thereof The present disclosure also provides pharmaceutical compositions comprising a therapeutically effective amount of one or more compounds according to Formula I or pharmaceutically acceptable salts, stereoisomers, and / or tautomers thereof in admixture with a pharmaceutically acceptable carrier. In some embodiments, the composition further comprises one or more additional therapeutic agents, pharmaceutically acceptable excipients, diluents, adjuvants, stabilizers, emulsifiers, preservatives, colorants, buffers, flavoring agents, in accordance with accepted practices of pharmaceutical compounding.

[0131] In one embodiment, the pharmaceutical composition comprises a compound selected from those shown in Table 1, or a pharmaceutically acceptable salt, stereoisomer, and / or tautomer thereof, and a pharmaceutically acceptable carrier.

[0132] The pharmaceutical compositions of the present disclosure are formulated, dosed, and administered in a manner consistent with good medical practice. Factors to consider in this context include the particular disorder being treated, the particular subject being treated, the clinical condition of the subject, the cause of the disorder, the site of delivery of the agent, the method of administration, the administration schedule, and other factors known to medical practitioners.

[0133] The present disclosure provides compounds of formula (I) that exhibit high antiviral potency, including those that inhibit the major protease (M) of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). pro ), ...

Claims

1. A compound of formula (I) or a pharmaceutically acceptable salt thereof. 【Chemical 1】 [In the formula, R １ teeth, C １ -C ６ -Alkyl, C ３ -C １０ -cycloalkyl, C ６ -C １０ -aryl, and 5-10 membered heteroaryl (1-4 heteroaryl ring members independently selected from N, O and S), wherein any of the alkyl, cycloalkyl, aryl and heteroaryl are mono- to perhalogenated, and optionally any of the alkyl, cycloalkyl, aryl and heteroaryl are mono- to perfluorinated, or any of the cycloalkyl, aryl and heteroaryl are 1-3 C １ -C ６ -substituted with haloalkyl; and P(O)(R １ａ ) ２ [Each R １ａ is C ６ -C １０ -aryl, 5- to 10-membered heteroaryl (1-4 heteroaryl ring members independently selected from N, O and S), and C optionally interrupted by one or more heteroatoms selected from -NH-, O and S １ -C ６ -alkyl; R ２ teeth, 【Chemistry 2】 , C １ -C ６ -alkyl, -(C １ -C ６ -alkyl)(C ３ -C １０ -cycloalkyl), -(C １ -C ６ -alkyl)(3-6 membered heterocycloalkyl) (1-4 ring members independently selected from C(O), N, O and S), -(C １ -C ６ -alkyl)(5-10 membered heteroaryl) (1-4 heteroaryl ring members independently selected from N, O and S), -(C １ -C ６ -alkyl)NR ６ R ７ , C １ -C ６ -Alkyl (-NH-, O and S(O) ０－２ may be interrupted by one or more heteroatoms selected from -(C １ -C ６ -alkyl)N(H)CN(H)NH ２ , and -(C １ -C ６ -alkyl)C(O)NR ６ R ７ is selected from the group consisting of R ６ and R ７ is H and C １ -C ６ - independently selected from alkyl; R ３ａ , R ３ｂ and R ４ In each case, H, C １ -C ８ -Alkyl, C ２ -C ８ -alkenyl, C ３ -C １０ -cycloalkyl, -(C １ -C ６ -alkyl)(C ３ -C １０ -cycloalkyl), -(C １ -C ６ -alkyl)(C ６ -C １０ -aryl), -(C １ -C ６ -alkyl)(3-6 membered heterocycloalkyl) (1-4 ring members independently selected from N, O and S), and -(C １ -C ６ -alkyl)(5-10 membered heteroaryl) (wherein 1-4 heteroaryl ring members are independently selected from N, O, and S); R ３ａ , R ３ｂ and R ４ Ha, halo, OH, NH ２ , N.H. ２ C which may be substituted with １ -C ６ -Alkyl, C １ -C ６ -haloalkyl, C １ -C ６ -alkoxy, C ３ -C ８ -cycloalkyl (halo and NH ２ CN, and CONR ６ R ７ optionally and independently substituted with 1 to 5 substituents independently selected from the group consisting of: or R ３ａ and R ４ , R ３ｂ and R ４ , or R ３ａ and R ３ｂ together with the atoms to which they are attached form a monocyclic or bicyclic ring having 3 to 10 ring members selected from C, N, O and S, which, when bicyclic, may be fused, bridged or spiro-fused, and said monocyclic or bicyclic ring is not further modified by halo, OH, C ２ -C ６ -alkenyl, C １ -C ６ -haloalkyl, C １ -C ６ -alkoxy, C ３ -C ８ -cycloalkyl (halo and NH ２ optionally and independently substituted with 1 to 3 substituents selected from ６ -C １０ -aryl, NH ２ C which may be substituted with １ -C ６ - alkyl, (C １ -C ６ -alkyl)-(C ３ -C ８ -cycloalkyl), 3-6 membered heterocycloalkyl (1-4 ring members independently selected from N, O and S), CN, and CONR ６ R ７ may be substituted with; A is a bond or a moiety of formula (II): 【Chemistry 3】 and R ８ and R ８ａ is H, C １ -C ８ -Alkyl, C ３ -C １０ -cycloalkyl, C ６ -C １０ -aryl, 3-6 membered heterocycloalkyl (1-4 ring members independently selected from N, O and S), 5-10 membered heteroaryl (1-4 heteroaryl ring members independently selected from N, O and S), -(C １ -C ６ -alkyl)(C ３ -C １０ -cycloalkyl), -(C １ -C ６ -alkyl)(C ６ -C １０ -aryl), -(C １ -C ６ -alkyl)(3-6 membered heterocycloalkyl) (1-4 ring members independently selected from N, O and S), and -(C １ -C ６ -alkyl)(5-10 membered heteroaryl) (wherein 1-4 heteroaryl ring members are independently selected from N, O, and S); R ８ and R ８ａ Ha, halo, OH, C １ -C ６ -alkoxy, C ３ -C ８ -cycloalkyl (halo and NH ２ and optionally substituted with 1 to 3 substituents independently selected from ２ , N.H. ２ C which may be substituted with １ -C ６ -Alkyl, CN, and CONR ６ R ７ and optionally and independently substituted with 1 to 5 substituents independently selected from the group consisting of: or R ４ and R ８ or R ８ and R ８ａ together with the atoms to which they are attached form a monocyclic or bicyclic ring having 3 to 10 ring members selected from C, N, O and S, which, when bicyclic, may be fused, bridged or spiro-fused, and said monocyclic or bicyclic ring is not further modified by halo, OH, C １ -C ６ -haloalkyl, C １ -C ６ -alkoxy, C ３ -C ８ -cycloalkyl (halo and NH ２ optionally and independently substituted with 1 to 3 substituents selected from ２ C which may be substituted with １ -C ６ -alkyl, 3-6 membered heterocycloalkyl (1-4 ring members independently selected from N, O and S), CN, CONR ６ R ７ may be substituted with; R ５ is C １ -C ２０ - alkyl (optionally interrupted by one or more heteroatoms selected from -NH-, O and S), C ２ -C ６ -alkenyl, C ６ -C １０ -aryl, 5-10 membered heteroaryl (1-4 heteroaryl ring members independently selected from N, O and S), -(C １ -C ６ -alkyl)(C ６ -C １０ -aryl), -O-(C １ -C ６ -alkyl)(C ６ -C １０ -aryl), -O-(C ３ -C ８ -cycloalkyl), —O—(C １ -C ６ -alkyl)(C ３ -C ８ -cycloalkyl), -(C １ -C ６ -alkyl)-O-(C ６ -C １０ -aryl), -(C １ -C ６ -alkyl)-NH-(C ６ -C １０ -aryl), -(C １ -C ６ -alkyl)-NHC(O)-(C ６ -C １０ -aryl), -(C ２ -C ６ -alkenyl)(C ６ -C １０ -aryl), -(C １ -C ６ -alkyl) (3-6 membered heterocyclic alkyl) (1-4 ring members are N, O and S(O) ０－２ independently selected from ３ -C ８ -cycloalkyl, -(C １ -C ６ -alkyl)-NH-(C ３ -C ８ -cycloalkyl), -(C １ -C ６ -alkyl)-(C ３ -C ８ -cycloalkyl), 3- to 14-membered heterocycloalkyl (1 to 4 ring members independently selected from N, O, and S), —O—(3- to 8-membered heterocycloalkyl (1 to 4 ring members independently selected from N, O, and S)), —(C １ -C ６ -alkyl)-(5-10 membered heteroaryl (1-4 heteroaryl ring members independently selected from N, O and S)), -C(O)-(C １ -C ６ -alkyl), -C(O)(C ６ -C １０ -aryl), -(C １ -C ６ -alkyl)-NH-(5-10 membered heteroaryl (1-4 heteroaryl ring members independently selected from N, O and S)), -CHN(OH), -(C １ -C ６ -alkyl)-NH-S(O) ２ -NR ９ R １０ ), —O—(C ２ -C ６ -alkenyl)-(C ６ -C １０ -aryl), -C(O)OR ９ , -(C １ -C ６ -alkyl)-C(O)OR ９ , -(C １ -C ６ -alkyl)-S(O) ２ -NH ２ , and —NH—C ６ -C １０ - selected from the group consisting of aryl, R ５ Ha, Halo, C １ -C ６ -Alkyl, C １ -C ６ -haloalkyl, oxo, -C １ -C ６ -Alkyl-NH ２ , -C ６ -C １０ -aryl (optionally substituted with 1 to 3 halo), -(C １ -C ６ -alkyl)(C ６ -C １０ -aryl), 5-10 membered heteroaryl (1-4 heteroaryl ring members independently selected from N, O and S), CN, OCF ３ , C.O.R. ９ , -OC(O)R ９ , C.O.R. ９ R １０ , -OCONR ９ R １０ , N.R. ９ R １０ , -NR ９ C(O)NR ９ R １０ , -NR ９ C(O)OR １０ , -NR ９ S (O) ２ R １０ , OR ９ , S.R. ９ , S.O. ２ R ９ , —N(H)C(O)(3- to 6-membered heterocycloalkyl), —N═O, and —N(H)C(O)CF ３ and two of the substituents, taken together with the carbon atoms to which they are attached, may form a monocyclic or bicyclic ring having 3 to 10 ring members selected from C, N, O and S; R ９ and R １０ is H, C １ -C ６ -Alkyl, C ３ -C ８ -cycloalkyl, C ６ -C １０ -aryl, and -(C １ -C ６ -alkyl)(C ６ -C １０ -aryl); or R ５ teeth, 【Chemistry 4】 and R １１ and R １２ is H, C １ -C ８ Alkyl, C ３ -C ８ -cycloalkyl, -(C １ -C ６ -alkyl)-C ３ -C ８ -cycloalkyl, -(C ３ -C ８ -cycloalkyl)(C ６ -C １０ -aryl), -(C ３ -C ８ -cycloalkyl)-(C １ -C ６ -alkyl), C ６ -C １０ -aryl, -(C １ -C ６ -alkyl)(C ６ -C １０ -aryl), 5-10 membered heteroaryl (1-4 heteroaryl ring members independently selected from N, O and S), -(C １ -C ６ -alkyl) (5-10 membered heteroaryl (1-4 heteroaryl ring members independently selected from N, O, and S)), 3-6 membered heterocycloalkyl (1-4 heteroaryl ring members independently selected from N, O, and S(O) ０－２ independently selected from １ -C ６ -alkyl) (3-8 membered heterocycloalkyl (1-4 ring members independently selected from N, O and S)), and -S(O) ２ -N(H)(C ６ -C １０ -aryl), R １１ and R １２ Ha, halo, OH, NH ２ , C １ -C ６ -haloalkyl, C １ -C ６ -Alkyl (halo and NH ２ or may be interrupted by one or more heteroatoms selected from —NH—, O and S), C １ -C ６ -alkoxy (optionally substituted with 1 to 3 halo), C ３ -C ８ -cycloalkyl (halo and NH ２ optionally and independently substituted with 1 to 3 substituents selected from １ -C ６ -alkyl)(C ６ -C １０ -aryl), and CONR ６ R ７ optionally substituted with 1 to 3 substituents independently selected from the group consisting of: or R １１ and R １２ together with the nitrogen atom to which they are attached form a monocyclic or bicyclic ring having 4 to 10 ring members selected from C, N, O and S, which, if bicyclic, may be fused, bridged or spiro-fused; The monocyclic or bicyclic ring may be selected from the group consisting of halo, OH, C １ -C ６ -haloalkyl, C(O)R ９ , C １ -C ６ -alkoxy, C ３ -C ８ -cycloalkyl (halo and NH ２ optionally and independently substituted with 1 to 3 substituents selected from ２ C which may be substituted with １ -C ６ -alkyl, 3-6 membered heterocycloalkyl (1-4 ring members independently selected from N, O and S), CN, and CONR ６ R ７ may be substituted with 1 to 3 substituents selected from:

2. R １ but, C １ -C ６ -Alkyl, C ３ -C １０ -cycloalkyl, C ６ -C １０ -aryl, and 5-10 membered heteroaryl (1-4 heteroaryl ring members independently selected from N, O and S), wherein any alkyl, cycloalkyl, aryl and heteroaryl are mono- or perfluorinated; and P(O)(R １ａ ) ２ [Each R １ａ is C ６ -C １０ -aryl, 5- to 10-membered heteroaryl (1-4 heteroaryl ring members independently selected from N, O and S), and C optionally interrupted by one or more heteroatoms selected from -NH-, O and S １ -C ６ -alkyl; R ２ but, 【Chemistry 5】 , -(C １ -C ６ -alkyl)(C ３ -C １０ -cycloalkyl), and -(C １ -C ６ -alkyl)N(H)CN(H)NH ２ , and -(C １ -C ６ -alkyl)C(O)NR ６ R ７ is selected from the group consisting of R ６ and R ７ However, H and C １ -C ６ - independently selected from alkyl; R ３ａ , R ３ｂ and R ４ In each case, H, C １ -C ８ -Alkyl, C ２ -C ８ -alkenyl, C ３ -C １０ -cycloalkyl, -(C １ -C ６ -alkyl)(C ３ -C １０ -cycloalkyl), -(C １ -C ６ -alkyl)(C ６ -C １０ -aryl), -(C １ -C ６ -alkyl)(3-6 membered heterocycloalkyl) (1-4 ring members independently selected from N, O and S), and -(C １ -C ６ -alkyl)(5-10 membered heteroaryl) (wherein 1-4 heteroaryl ring members are independently selected from N, O, and S); R ３ａ , R ３ｂ and R ４ But, halo, OH, NH ２ , N.H. ２ C which may be substituted with １ -C ６ -Alkyl, C １ -C ６ -haloalkyl, C １ -C ６ -alkoxy, C ３ -C ８ -cycloalkyl (halo and NH ２ CN, and CONR ６ R ７ optionally and independently substituted with 1 to 5 substituents independently selected from the group consisting of: or R ３ａ and R ４ , R ３ｂ and R ４ , or R ３ａ and R ３ｂ together with the atoms to which they are attached form a monocyclic or bicyclic ring having 3 to 10 ring members selected from C, N, O and S, which, when bicyclic, may be fused, bridged or spiro-fused, and said monocyclic or bicyclic ring is not further modified by halo, OH, C ２ -C ６ -alkenyl, C １ -C ６ -haloalkyl, C １ -C ６ -alkoxy, C ３ -C ８ -cycloalkyl (halo and NH ２ optionally and independently substituted with 1 to 3 substituents selected from ２ C which may be substituted with １ -C ６ -alkyl, 3-6 membered heterocycloalkyl (1-4 ring members independently selected from N, O and S), CN, and CONR ６ R ７ may be substituted with; A is a bond or a moiety of formula (II): 【Chemistry 6】 and R ８ and R ８ａ But H, C １ -C ８ -Alkyl, C ３ -C １０ -cycloalkyl, C ６ -C １０ -aryl, 3-6 membered heterocycloalkyl (1-4 ring members independently selected from N, O and S), 5-10 membered heteroaryl (1-4 heteroaryl ring members independently selected from N, O and S), -(C １ -C ６ -alkyl)(C ３ -C １０ -cycloalkyl), -(C １ -C ６ -alkyl)(C ６ -C １０ -aryl), -(C １ -C ６ -alkyl)(3-6 membered heterocycloalkyl) (1-4 ring members independently selected from N, O and S), and -(C １ -C ６ -alkyl)(5-10 membered heteroaryl) (wherein 1-4 heteroaryl ring members are independently selected from N, O, and S); R ８ and R ８ａ But, Halo, OH, C １ -C ６ -alkoxy, C ３ -C ８ -cycloalkyl (halo and NH ２ and optionally substituted with 1 to 3 substituents independently selected from ２ , N.H. ２ C which may be substituted with １ -C ６ -Alkyl, CN, and CONR ６ R ７ and optionally and independently substituted with 1 to 5 substituents independently selected from the group consisting of: or R ４ and R ８ or R ８ and R ８ａ together with the atoms to which they are attached form a monocyclic or bicyclic ring having 3 to 10 ring members selected from C, N, O and S, which, when bicyclic, may be fused, bridged or spiro-fused, and said monocyclic or bicyclic ring is not further modified by halo, OH, C １ -C ６ -haloalkyl, C １ -C ６ -alkoxy, C ３ -C ８ -cycloalkyl (halo and NH ２ optionally and independently substituted with 1 to 3 substituents selected from ２ C which may be substituted with １ -C ６ -alkyl, 3-6 membered heterocycloalkyl (1-4 ring members independently selected from N, O and S), CN, CONR ６ R ７ may be substituted with; R ５ But C １ -C ２０ - alkyl (optionally interrupted by one or more heteroatoms selected from -NH-, O and S), C ６ -C １０ -aryl, 5-10 membered heteroaryl (1-4 heteroaryl ring members independently selected from N, O and S), -(C １ -C ６ -alkyl)(C ６ -C １０ -aryl), -O-(C １ -C ６ -alkyl)(C ６ -C １０ -aryl), -O-(C ３ -C ８ -cycloalkyl), —O—(C １ -C ６ -alkyl)(C ３ -C ８ -cycloalkyl), -(C １ -C ６ -alkyl)-O-(C ６ -C １０ -aryl), -(C １ -C ６ -alkyl)-NH-(C ６ -C １０ -aryl), -(C １ -C ６ -alkyl)-NHC(O)-(C ６ -C １０ -aryl), -(C ２ -C ６ -alkenyl)(C ６ -C １０ -aryl), -(C １ -C ６ -alkyl) (3-6 membered heterocyclic alkyl) (1-4 ring members are N, O and S(O) ０－２ independently selected from ３ -C ８ -cycloalkyl, 3- to 14-membered heterocycloalkyl (1-4 ring members independently selected from N, O, and S), -O-(3- to 6-membered heterocycloalkyl (1-4 ring members independently selected from N, O, and S)), -(C １ -C ６ -alkyl)-(5-10 membered heteroaryl (1-4 heteroaryl ring members independently selected from N, O and S)), and -(C １ -C ６ -alkyl)-NH-(5-10 membered heteroaryl, wherein 1-4 heteroaryl ring members are independently selected from N, O, and S); R ５ But, Halo, C １ -C ６ -Alkyl, C １ -C ６ -haloalkyl, -C １ -C ６ -Alkyl-NH ２ , -C ６ -C １０ -aryl, -(C １ -C ６ -alkyl)(C ６ -C １０ -aryl), CN, COR ９ , -OC(O)R ９ , C.O.R. ９ R １０ , -OCONR ９ R １０ , N.R. ９ R １０ , -NR ９ C(O)NR ９ R １０ , -NR ９ C(O)OR １０ , OR ９ , S.R. ９ , S.O. ２ R ９ , —N(H)C(O)(3- to 6-membered heterocycloalkyl), and —N(H)C(O)CF ３ and two of the substituents, taken together with the carbon atoms to which they are attached, may form a monocyclic or bicyclic ring having 3 to 10 ring members selected from C, N, O and S; R ９ and R １０ But H, C １ -C ６ -Alkyl, C ３ -C ８ -cycloalkyl, C ６ -C １０ -aryl, and -(C １ -C ６ -alkyl)(C ６ -C １０ -aryl); or R ５ but, 【Chemistry 7】 and R １１ and R １２ But H, C １ -C ８ Alkyl, C ３ -C ８ -cycloalkyl, -(C １ -C ６ -alkyl)-C ３ -C ８ -cycloalkyl, C ６ -C １０ -aryl, -(C １ -C ６ -alkyl)(C ６ -C １０ -aryl), 5-10 membered heteroaryl (1-4 heteroaryl ring members independently selected from N, O and S), -(C １ -C ６ -alkyl) (5-10 membered heteroaryl (1-4 heteroaryl ring members independently selected from N, O, and S)), 3-6 membered heterocycloalkyl (1-4 ring members independently selected from N, O, and S), -(C １ -C ６ -alkyl) (3-6 membered heterocycloalkyl (1-4 ring members independently selected from N, O and S)), and -S(O) ２ -N(H)(C ６ -C １０ -aryl), R １１ and R １２ But, halo, OH, NH ２ , C １ -C ６ -Alkyl (halo and NH ２ optionally and independently substituted with 1 to 3 substituents selected from １ -C ６ -alkoxy, C ３ -C ８ -cycloalkyl (halo and NH ２ optionally and independently substituted with 1 to 3 substituents selected from １ -C ６ -alkyl)(C ６ -C １０ -aryl), and CONR ６ R ７ optionally substituted with 1 to 3 substituents independently selected from the group consisting of: or R １１ and R １２ together with the nitrogen atom to which they are attached form a monocyclic or bicyclic ring having 4 to 10 ring members selected from C, N, O and S, which, if bicyclic, may be fused, bridged or spiro-fused; The monocyclic or bicyclic ring is selected from the group consisting of halo, OH, C １ -C ６ -haloalkyl, C １ -C ６ -alkoxy, C ３ -C ８ -cycloalkyl (halo and NH ２ optionally and independently substituted with 1 to 3 substituents selected from ２ C which may be substituted with １ -C ６ -alkyl, 3-6 membered heterocycloalkyl (1-4 ring members independently selected from N, O and S), CN, and CONR ６ R ７ The compound according to claim 1, or a pharmaceutically acceptable salt thereof, optionally substituted with 1 to 3 substituents selected from:

3. R １ Mono- or perfluorinated C １ -C ６ -Alkyl or C ６ -C １０ 3. The compound of claim 1 or 2, wherein -aryl, or a pharmaceutically acceptable salt thereof.

4. R １ Mono- or perfluorinated C １ -C ６ 3. The compound of claim 1 or 2, wherein - is alkyl, or a pharmaceutically acceptable salt thereof.

5. R １ Ga-CHF ２ and -CF ３ 3. The compound of claim 1 or 2, or a pharmaceutically acceptable salt thereof, selected from:

6. R １ Mono- or perfluorinated C ６ -C １０ 3. The compound of claim 1 or 2, wherein -aryl, or a pharmaceutically acceptable salt thereof.

7. R １ 3. The compound of claim 1 or 2, or a pharmaceutically acceptable salt thereof, wherein is tetrafluorophenyl.

8. R １ but 【Chemistry 8】 3. The compound of claim 1 or 2, wherein:

9. R ２ but 【Chemistry 9】 3. The compound of claim 1 or 2, wherein:

10. R ２ but 【Chemistry 10】 3. The compound of claim 1 or 2, wherein:

11. R ２ but 【Chemistry 11】 3. The compound of claim 1 or 2, wherein:

12. R ６ 3. The compound of claim 1 or 2, wherein is H, or a pharmaceutically acceptable salt thereof.

13. R ３ａ is H and R ３ｂ C, which may be substituted １ -C ８ -alkyl and -(C １ -C ６ -alkyl)(C ３ -C １０ -cycloalkyl), or a pharmaceutically acceptable salt thereof.

14. R ３ａ is H and R ３ｂ C, which may be substituted １ -C ８ 3. The compound of claim 1 or 2, wherein - is alkyl, or a pharmaceutically acceptable salt thereof.

15. R ３ａ is H and R ３ｂ but 【Chemistry 12】 3. The compound of claim 1 or 2, wherein:

16. The part 【Chemistry 13】 In this case, R ３ａ is H and R ３ｂ and R ４ together with the atoms to which they are attached form an optionally substituted 3- to 10-membered monocyclic or bicyclic ring, which, if bicyclic, may be fused, bridged or spiro-fused, or a pharmaceutically acceptable salt thereof.

17. The part 【Chemistry 14】 but, 【Chemistry 15】 【change】 17. The compound of claim 16, selected from the group consisting of: or a pharmaceutically acceptable salt thereof.

18. 3. The compound of claim 1 or 2, or a pharmaceutically acceptable salt thereof, wherein A is a bond.

19. R ５ but 【Chemistry 16】 3. The compound of claim 1 or 2, wherein:

20. R １１ 3. The compound of claim 1 or 2, wherein is H, or a pharmaceutically acceptable salt thereof.

21. R ５ but, 【Chemistry 17】 【change】 3. The compound of claim 1 or 2, selected from the group consisting of: or a pharmaceutically acceptable salt thereof.

22. R ５ but, 【Chemistry 18】 3. The compound of claim 1 or 2, selected from the group consisting of: or a pharmaceutically acceptable salt thereof.

23. A is a moiety of formula (II): 【Chemistry 19】 3. The compound of claim 1 or 2, wherein:

24. R ８ａ 3. The compound of claim 1 or 2, wherein is H, or a pharmaceutically acceptable salt thereof.

25. R ４ and R ８ together with the atoms to which they are attached form an optionally substituted monocyclic or bicyclic ring having 3 to 10 ring members selected from C, N, O and S, which, when bicyclic, may be fused, bridged or spiro-fused, or a pharmaceutically acceptable salt thereof.

26. The moiety of formula (II) is 【Chemistry 20】 3. The compound of claim 1 or 2, selected from the group consisting of: or a pharmaceutically acceptable salt thereof.

27. R １ Mono- or perfluorinated C １ -C ６ -Alkyl or C ６ -C １０ -aryl; R ２ but 【Chemical 21】 and R ３ａ , R ３ｂ , and R ４ But H, C １ -C ８ -alkyl, -(C １ -C ６ -alkyl)(C ３ -C １０ -cycloalkyl), -(C １ -C ６ -alkyl)(C ６ -C １０ -aryl), and -(C １ -C ６ -alkyl)(3- to 6-membered heterocycloalkyl) (1-4 ring members independently selected from N, O and S); R ３ｂ is optionally substituted with 1 to 5 halo; or R ３ａ and R ４ , R ３ｂ and R ４ , or R ３ａ and R ３ｂ together with the atoms to which they are attached form a monocyclic or bicyclic ring having 3 to 10 ring members selected from C, N, O and S, which, if bicyclic, may be fused, bridged or spiro-fused, and said monocyclic or bicyclic ring is １ -C ６ -Alkyl, C １ -C ６ -haloalkyl, and C ６ -C １０ -optionally substituted with aryl; A is a bond; R ５ But C １ -C ２０ -alkyl (optionally interrupted by one or more heteroatoms selected from -NH-, O and S), 5-10 membered heteroaryl (1-4 heteroaryl ring members independently selected from N, O and S), -O-(C １ -C ６ -alkyl)(C ６ -C １０ -aryl), C ６ -C １０ -aryl, C ３ -C ８ -cycloalkyl, 3- to 14-membered heterocycloalkyl (1-4 ring members independently selected from N, O and S), -(C １ -C ６ -alkyl)(C ６ -C １０ -aryl), -(C １ -C ６ -alkyl)-(C ３ -C ８ -cycloalkyl), -C(O)-(C １ -C ６ -alkyl), and C ２ -C ６ - selected from the group consisting of alkenyl; R ５ But, halo, -C ６ -C １０ -aryl (optionally substituted with 1 to 3 substituents selected from halo), C １ -C ６ -haloalkyl, OR ９ , C １ -C ６ - alkyl, OCF ３ , -OC(O)R ９ , -OCONR ９ R １０ , and -NR ９ C(O)OR １０ optionally substituted with 1 to 3 substituents selected from the group consisting of: R ９ and R １０ But H, C １ -C ６ -Alkyl, C ３ -C ８ -cycloalkyl, and -(C １ -C ６ -alkyl)(C ６ -C １０ -aryl); or R ５ but 【Chemical 22】 and R １１ and R １２ But H, C １ -C ８ Alkyl, C ６ -C １０ -aryl, and C ３ -C ８ -cycloalkyl; R １１ and R １２ But, Halo, C １ -C ６ -haloalkyl, 3-6 membered heterocycloalkyl (1-4 ring members are N, O and S(O) ０－２ independently selected from １ -C ６ -Alkyl (halo and NH ２ or may be interrupted by one or more heteroatoms selected from —NH—, O and S), and C １ -C ６ -alkoxy (optionally substituted with 1 to 3 halo), or a pharmaceutically acceptable salt thereof.

28. R １ is trifluoromethyl or tri- or perfluorinated phenyl; R ２ but 【Chemical 23】 and R ３ａ is H and R ４ is H and R ３ｂ Ga-CH ２ -cyclopropyl, -CH ２ -cyclobutyl, -CH ２ -cyclohexyl, isobutyl, neopentyl optionally substituted with 1 to 3 fluoro groups, benzyl, or -CH ２ -tetrahydropyranyl, or R ３ａ is H and R ３ｂ and R ４ together with the atoms to which they are attached form a monocyclic or bicyclic ring having 5 to 8 ring members selected from C and N, which, if bicyclic, is fused or spiro-fused, and said monocyclic or bicyclic ring is optionally substituted with methyl, trifluoromethyl, or phenyl; A is a bond; R ５ is methyl, n-Pr, i-Pr, isobutyl, n-butyl, perdeuterated n-butyl, sec-butyl, iso-pentyl, tert-pentyl, neo-heptyl, 2-methylpentyl, 2,4-dimethylpentyl, 1-methoxy-3-methylbutyl, indolyl, thiazolyl, benzyloxy, 1,3-benzodioxolyl, isoxazolyl, 1,2-benzisoxazolyl, benzoxazolyl, imidazo[1,2-b]pyridazinyl, 1,4-dioxanyl, tetrahydrofuranyl, 2-oxabicyclo[2.1.1]hexanyl, 7-oxabicyclo[2.2.1]heptanyl, benzyl, -(CH ２ ) ２ -cyclopropyl, cyclopropyl, -CH ２ - selected from the group consisting of cyclobutyl, cyclobutyl, cyclopentyl, cyclohexyl, -C(O)-(isobutyl), -C(O)-(iso-pentyl), and 3-methylbut-1-enyl; R ５ is fluoro, chloro, phenyl (which may be substituted with 1 to 3 fluoro), monofluoro-i-Pr, difluoro-i-Pr, trifluoromethyl, methyl, tert-butyl, hydroxy, methoxy, OCF ３ , —OC(O)NR ９ R １０ , -OC(O)R ９ , and -NR ９ C(O)OR １０ optionally substituted with 1 to 3 substituents selected from the group consisting of: R ９ and R １０ are independently selected from the group consisting of H, ethyl, i-Pr, tert-butyl, cyclohexyl, and benzyl; or R ５ but 【Chemistry 24】 and R １１ and R １２ are independently selected from the group consisting of H, methyl, tert-butyl, phenyl, cyclopropyl, cyclobutyl, cyclohexyl, and bicyclo[1.1.1]pentanyl; R １１ and R １２ is optionally substituted with 1 to 3 substituents independently selected from the group consisting of fluoro, chloro, monofluoromethyl, trifluoromethyl, tetrahydropyranyl, methyl, and methoxy, or a pharmaceutically acceptable salt thereof.

29. R １ Mono- or perfluorinated C １ -C ６ -Alkyl or C ６ -C １０ -aryl; R ２ but 【Chemistry 25】 and R ３ａ , R ３ｂ , and R ４ But H, C １ -C ８ - independently selected from alkyl; or R ３ａ and R ４ , R ３ｂ and R ４ , or R ３ａ and R ３ｂ together with the atoms to which they are attached form a monocyclic or bicyclic ring having 3 to 10 ring members selected from C, N, O and S, which, if bicyclic, is fused or spiro-fused, and said monocyclic or bicyclic ring is １ -C ６ -Alkyl or C １ -C ６ -optionally substituted with haloalkyl; A is a bond; R ５ But C １ -C ２０ -alkyl (optionally interrupted by one or more heteroatoms selected from -NH-, O and S), 5-10 membered heteroaryl (1-4 heteroaryl ring members independently selected from N, O and S), C ３ -C ８ -cycloalkyl, 3- to 14-membered heterocycloalkyl (1-4 ring members independently selected from N, O and S), and -(C １ -C ６ -alkyl)(C ６ -C １０ -aryl); R ５ But, Halo, C １ -C ６ -optionally substituted with 1 to 3 substituents selected from the group consisting of haloalkyl, and OH; or R ５ but 【Chemical 26】 and R １１ and R １２ But H, C １ -C ８ Alkyl, C ６ -C １０ -aryl, and C ３ -C ８ -cycloalkyl; R １１ and R １２ But, Halo, C １ -C ６ -haloalkyl, and C １ -C ６ -Alkyl (halo and NH ２ or optionally interrupted by one or more heteroatoms selected from -NH-, O and S.

30. R １ is trifluoromethyl or tetrafluorinated phenyl; R ２ but 【Chemical 27】 and R ３ａ is H and R ４ is H and R ３ｂ is isobutyl or neopentyl, or R ３ａ is H and R ３ｂ and R ４ together with the atoms to which they are attached form a monocyclic or bicyclic ring having 5 to 8 ring members selected from C and N, which, if bicyclic, is fused or spiro-fused, said monocyclic or bicyclic ring being optionally substituted with methyl or trifluoromethyl; A is a bond; R ５ is selected from the group consisting of methyl, iso-pentyl, indolyl, isoxazolyl, tetrahydrofuranyl, 2-oxabicyclo[2.1.1]hexanyl, and benzyl; R ５ is optionally substituted with 1 to 3 substituents selected from the group consisting of fluoro, monofluoro-i-Pr, trifluoromethyl, and hydroxy; or R ５ but 【Chemical 28】 and R １１ and R １２ is independently selected from the group consisting of H, methyl, tert-butyl, phenyl, cyclopropyl, cyclohexyl, and bicyclo[1.1.1]pentanyl; R １１ and R １２ is optionally substituted with 1 to 3 substituents independently selected from the group consisting of fluoro, trifluoromethyl, and methyl, or a pharmaceutically acceptable salt thereof.

31. R ５ but, 【Chemical Formula 29】 28. The compound of claim 27, selected from the group consisting of: or a pharmaceutically acceptable salt thereof.

32. R ５ but, 【Chemistry 30】 【change】 28. The compound of claim 27, wherein R is selected from the group consisting of: Me, Et, i-Pr, n-pentyl, and t-Bu, or a pharmaceutically acceptable salt thereof.

33. R ５ but, 【Chemical 31】 30. The compound of claim 29, or a pharmaceutically acceptable salt thereof, selected from the group consisting of:

34. R １ Mono- or perfluorinated C １ -C ６ - alkyl; R ２ but 【Chemical 32】 and The part 【Chemical 33】 In this case, R ３ａ is H, and R ３ｂ and R ４ together with the atoms to which they are attached form an optionally substituted 3- to 10-membered monocyclic or bicyclic ring, which, if bicyclic, may be fused, bridged or spiro-fused; A is a bond; R ５ But C １ -C ６ -alkyl (optionally interrupted by one or more heteroatoms selected from -NH-, O and S), which is halo, C １ -C ６ -Alkyl, C １ -C ６ -haloalkyl, and OR ９ The compound according to claim 1, or a pharmaceutically acceptable salt thereof, optionally substituted with 1 to 3 substituents selected from the group consisting of:

35. The compound is 4-methoxy-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-1H-indole-2-carboxamide; N-((S)-1-(((S)-4-(2,6-difluorophenoxy)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide; (S)-3-((S)-2-(4-methoxy-1H-indole-2-carboxamido)-4-methylpentanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butyl 2,6-dichlorobenzoate; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-1H-indole-2-carboxamide; N-((S)-3-cyclohexyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)-1H-indole-2-carboxamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-1H-indole-2-carboxamide; N-((S)-1-(((S)-4-(2,6-difluorophenoxy)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide; (S)-3-((S)-2-(4-methoxy-1H-indole-2-carboxamido)-4-methylpentanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butyl 2,6-dichlorobenzoate; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)benzamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-phenyloxalamide; 5-fluoro-N-((S)-5-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)hexan-2-yl)-1H-indole-2-carboxamide; 5-fluoro-N-((S)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)-4-phenylbutan-2-yl)-1H-indole-2-carboxamide; N-((S)-4,4-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-5-fluoro-1H-indole-2-carboxamide; 5-fluoro-N-((S)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)-3-phenylpropan-2-yl)-1H-indole-2-carboxamide; benzyl ((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)carbamate; 5-fluoro-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-1H-indole-2-carboxamide; 5-fluoro-N-((S)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)-3-(4-(trifluoromethyl)phenyl)propan-2-yl)-1H-indole-2-carboxamide; 5-fluoro-N-((S)-4-fluoro-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-1H-indole-2-carboxamide; 5-fluoro-N-((2S)-3-(4-methoxyphenyl)-1-oxo-1-(((2S)-3-oxo-1-(2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)-1H-indole-2-carboxamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)quinoline-2-carboxamide; Cyclopentyl ((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)carbamate; 3-chlorobenzyl ((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)carbamate; 4-fluorobenzyl ((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)carbamate; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)benzo[d][1,3]dioxole-5-carboxamide; 1-(cyclopentanecarbonyl)-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)piperidine-4-carboxamide; (R)—N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)tetrahydrofuran-2-carboxamide; 1-(cyclopentanecarbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)piperidine-4-carboxamide; N1-(2-fluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide; N1-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)-N2-phenyloxalamide; N1-((S)-3-cyclobutyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)-N2-phenyloxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-(2-(trifluoromethyl)phenyl)oxalamide; N1-(2-(tert-butyl)phenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-(naphthalen-2-yl)oxalamide; N1-((S)-3-cyclohexyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)-N2-phenyloxalamide; N1-((S)-5-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)hexan-2-yl)-N2-phenyloxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-(o-tolyl)oxalamide; N1-(4-fluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(4-chlorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; (S)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)-2-(2-(phenylamino)acetamido)pentanamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-phenethyloxalamide; N1-benzyl-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(3-fluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-3-cyclopentyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)-N2-phenyloxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-(pyridin-2-yl)oxalamide; N1-(2-chlorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2,6-difluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-(2-(trifluoromethyl)pyridin-3-yl)oxalamide; N1-((2S)-1-(((2S)-3-hydroxy-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-N2-phenyloxalamide; (S)-3-((S)-2-(5-fluoro-1H-indole-2-carboxamido)-4-methylpentanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butyl diphenylphosphinate; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-(naphthalen-1-yl)oxalamide; N1-(3-chlorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(3,4-difluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; (R)-N4-(2-fluorobenzyl)-2-isobutyl-N1-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)succinamide; (R)-N4-(2,6-difluorobenzyl)-2-isobutyl-N1-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)succinamide; N1-(2-bromophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2-benzylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pent-4-en-2-yl)-N2-phenyloxalamide; N1-(2,5-dichlorobenzyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; (S)-2-((E)-3-(2-fluorophenyl)acrylamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)pentanamide; N1-((S)-3-cyclohexyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)-N2-(2-fluorophenyl)oxalamide; N1-(2-(difluoromethoxy)phenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2-ethylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2,6-dimethylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2,3-dimethylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; (S)-2-Cinnamamido-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)pentanamide; 5-(2-fluorophenyl)-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)isoxazole-3-carboxamide; N1-(2-fluoro-4-methylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-cyclohexyl-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-5-phenylisoxazole-3-carboxamide; N1-(2,3-difluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2,5-difluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; (S)-3-((S)-4-methyl-2-(2-oxo-2-(phenylamino)acetamido)pentanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butyl diphenylphosphinate; N1-(4-fluoro-2-methylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2-cyanophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(3,3-difluoro-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-(2-fluorophenyl)oxalamide; N1-(4-chloro-2-methylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2,4-difluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(5-fluoro-2-methoxyphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-1-(((S)-1-cyclohexyl-3-oxo-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-N2-(2-fluorophenyl)oxalamide; N1-(cyclopentylmethyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2-fluoro-6-methylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(5-fluoro-2-methylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; (S)-2-(3-(2-fluorophenyl)ureido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)pentanamide; N1-(2-fluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2-isopropylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(4-bromo-3,5-difluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2-chlorophenyl)-N2-((S)-3-(4,4-difluorocyclohexyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)oxalamide; N1-(3-fluoro-2-methylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2-fluorophenyl)-N2-((S)-3-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)butan-2-yl)oxalamide; (S)-1-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)pyrrolidine-2-carboxamide; N1-(2-chlorophenyl)-N2-((S)-3-cyclohexyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)oxalamide; N1-((S)-3-cyclohexyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)-N2-(o-tolyl)oxalamide; N1-(3,3-difluorocyclohexyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; (R)-1-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)piperidine-3-carboxamide; N1-(4-bromo-2-fluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; (2S)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)-2-(3,3,3-trifluoro-2-((2-fluorophenyl)amino)propanamido)pentanamide; N1-cyclopropyl-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-(1-methylcyclopropyl)oxalamide; N1-(tert-butyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-(tetrahydro-2H-pyran-4-yl)oxalamide; N1-cyclopentyl-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-((S)-tetrahydro-2H-pyran-3-yl)oxalamide; (S)-2-(2-(4-acetylpiperazin-1-yl)-2-oxoacetamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)pentanamide; N1-methyl-N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-(o-tolyl)oxalamide; N1-((S)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)-3-phenylpropan-2-yl)-N2-(o-tolyl)oxalamide; N1-methyl-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N1-(o-tolyl)oxalamide; N1-((S)-4-cyclohexyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)butan-2-yl)-N2-(2-fluorophenyl)oxalamide; N1-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)-N2-(2-fluorophenyl)oxalamide; N-((S)-3-cyclohexyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)-5-(2-fluorophenyl)isoxazole-3-carboxamide; N1-(2-benzylphenyl)-N2-((S)-3-cyclohexyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)oxalamide; N1-(2-methoxyphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-(2-(trifluoromethoxy)phenyl)oxalamide; 5-methyl-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)isoxazole-3-carboxamide; 5-methyl-N-((S)-3-methyl-1-(((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)amino)-1-oxobutan-2-yl)isoxazole-3-carboxamide; N1-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)-N2-(o-tolyl)oxalamide; N1-(2-(tert-butyl)phenyl)-N2-((S)-3-cyclohexyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)oxalamide; N-((S)-3,3-dimethyl-1-(((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)amino)-1-oxobutan-2-yl)-5-methylisoxazole-3-carboxamide; N1-((S)-3,3-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)butan-2-yl)-N2-(2-fluorophenyl)oxalamide; N1-(3-methoxyphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(4-methoxyphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-phenyloxalamide; N1-((S)-1-(((S)-6-(dimethylamino)-2,6-dioxo-1-(2,3,5,6-tetrafluorophenoxy)hexan-3-yl)amino)-4-methyl-1-oxopentan-2-yl)-N2-(2-fluorophenyl)oxalamide; N1-cyclobutyl-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; (S)-3-((S)-2-(2-((2-fluorophenyl)amino)-2-oxoacetamido)-4-methylpentanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butyl diphenylphosphinate; (R)-tetrahydrofuran-3-yl((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)carbamate; (S)-Tetrahydrofuran-3-yl((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)carbamate; 3-(3-chlorophenyl)propyl((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)carbamate; N1-(2-fluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopiperidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4,4-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-(2-fluorophenyl)oxalamide; N1-(2-fluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,4,6-trifluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2-fluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,6-trifluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-((R)-tetrahydro-2H-pyran-3-yl)oxalamide; N1-(2-chlorophenyl)-N2-(1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)-3-(tetrahydro-2H-pyran-4-yl)propan-2-yl)oxalamide; N1-((S)-1-(((S)-1-(1H-imidazol-5-yl)-3-oxo-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-N2-(2-fluorophenyl)oxalamide; N1-((S)-1-(((R)-1-(1H-imidazol-5-yl)-3-oxo-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-N2-(2-fluorophenyl)oxalamide; Cyclopentylmethyl ((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)carbamate; 3-chlorophenethyl ((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)carbamate; (E)-3-(3-chlorophenyl)allyl((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)carbamate; N1-(1-acetylpiperidin-4-yl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2-fluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-((5-(trifluoromethyl)isoxazol-3-yl)oxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-1-(((S)-7-amino-2-oxo-1-(2,3,5,6-tetrafluorophenoxy)heptan-3-yl)amino)-4-methyl-1-oxopentan-2-yl)-N2-(2-fluorophenyl)oxalamide; N1-(2-(methoxymethyl)phenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; (S)-2-(2-(3-chlorophenyl)acetamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)pentanamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-((S)-1,2,3,4-tetrahydronaphthalen-1-yl)oxalamide; (S)-2-((R)-2-(3-chlorophenyl)-2-hydroxyacetamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)pentanamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-((R)-1,2,3,4-tetrahydronaphthalen-1-yl)oxalamide; N1-((S)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)-3-(pyridin-2-yl)propan-2-yl)-N2-(o-tolyl)oxalamide; (S)-2-(2-(3,4-dihydroquinolin-1(2H)-yl)-2-oxoacetamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)pentanamide; (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)carbamate; N1-(4,4-difluorocyclohexyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2,6-dimethylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; 2,2-difluoro-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)benzo[d][1,3]dioxole-5-carboxamide; (S)-2-(2-(5-acetyl-2-methoxyphenyl)acetamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)pentanamide; N1-((S)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)-3-(pyridin-2-yl)propan-2-yl)-N2-(o-tolyl)oxalamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1H-benzo[d]imidazole-2-carboxamide; N-((S)-1-(((S)-4-((1,1,1,3,3,3-hexafluoropropan-2-yl)oxy)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide; 4-methoxy-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1H-indole-2-carboxamide; N1-(2,6-diisopropylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-5-(2-fluorophenyl)isoxazole-3-carboxamide; N-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-5-fluoro-1H-indole-2-carboxamide; 4-methoxy-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,2,2-trifluoroethoxy)butan-2-yl)amino)pentan-2-yl)-1H-indole-2-carboxamide; N1-cyclohexyl-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2,6-dimethoxyphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2-methoxy-6-methylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2-fluoro-6-methoxyphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2,6-diethylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)benzo[d][1,3]dioxole-5-carboxamide; N1-(2,2-difluorocyclohexyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2,6-diisopropoxyphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; 5-(2-fluorophenyl)-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)isoxazole-3-carboxamide; N1-(tert-butyl)-N2-((S)-4,4-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2-(tert-butyl)phenyl)-N2-((S)-4,4-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-cyclopropyl-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2-fluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-((1,1,3,3-tetrafluoropropan-2-yl)oxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(3,3-difluorocyclobutyl)oxalamide; N1-(2-(methoxymethyl)phenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; 4-methoxy-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-((1,1,3,3-tetrafluoropropan-2-yl)oxy)butan-2-yl)amino)pentan-2-yl)-1H-indole-2-carboxamide; N1-(3,3-difluorocyclobutyl)-N2-((S)-4,4-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(tert-butyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(tert-butyl)-N2-(1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)-3-(tetrahydro-2H-pyran-4-yl)propan-2-yl)oxalamide; N1-(3,3-difluorocyclobutyl)-N2-((S)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)-3-phenylpropan-2-yl)oxalamide; 5-(2-fluorophenyl)-N-(1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)-3-(tetrahydro-2H-pyran-4-yl)propan-2-yl)isoxazole-3-carboxamide; N-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-5-(4-fluorophenyl)-1,3,4-oxadiazole-2-carboxamide; N1-(2,6-dicyclopropylphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(1-(p-tolyl)cyclopropyl)oxalamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; N1-(3-methoxyphenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(2,2,2-trifluoroethyl)oxalamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-2-oxopiperidine-3-carboxamide; N1-(bicyclo[1.1.1]pentan-1-yl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-3-phenyl-1H-pyrazole-5-carboxamide; N1-(1-methoxy-2-methylpropan-2-yl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1H-pyrrolo[2,3-b]pyridine-2-carboxamide; (3S)-3-((S)-2-(4-methoxy-1H-indole-2-carboxamido)-4-methylpentanamido)-2-oxo-4-(2-oxopyrrolidin-3-yl)butyl diphenylphosphinate; (2S)-2-(2-(3,4-dihydroquinolin-1(2H)-yl)-2-oxoacetamido)-4-methyl-N-((2S)-3-oxo-1-(2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; N1-(2-fluorophenyl)-N2-((S)-3-methyl-1-(1-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)-1H-1,2,3-triazol-4-yl)butyl)oxalamide; N-((S)-1-(((S)-4-(difluoromethoxy)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide; 3-chlorobenzyl ((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)carbamate; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide; N-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)benzo[d]oxazole-2-carboxamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)imidazo[1,2-a]pyridine-2-carboxamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)imidazo[1,2-b]pyridazine-2-carboxamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)indoline-2-carboxamide; N1-(3,3-difluorocyclobutyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(o-tolyl)oxalamide; (S)-2-((R)-2-hydroxy-3-phenylpropanamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; N-((S)-6-amino-1-(((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)amino)-1-oxohexan-2-yl)-2-fluorobenzamide; 5-(3-fluorophenyl)-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1H-imidazole-2-carboxamide; 5-(2-methoxyphenyl)-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1H-imidazole-2-carboxamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(1,1,1-trifluoro-2-methylpropan-2-yl)oxalamide; N1-((S)-3-cyclohexyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(1,1,1-trifluoro-2-methylpropan-2-yl)oxalamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-5-oxotetrahydrofuran-2-carboxamide; 2-methyl-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)tetrahydrofuran-2-carboxamide; N1-((S)-3-(3-fluorophenyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(1-methylcyclopropyl)oxalamide; N1-(1-(2-fluorophenyl)cyclopropyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(1-methylcyclopropyl)oxalamide; N1-(2-fluorophenyl)-N2-((2S)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)-3-(2-oxopyrrolidin-3-yl)propan-2-yl)oxalamide; N1-(2-fluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopiperidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(3,3-difluoro-1-methylcyclobutyl)oxalamide; N1-cyclobutyl-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(4-methyltetrahydro-2H-pyran-4-yl)oxalamide; N-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-5-phenyl-1H-imidazole-2-carboxamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-5-phenyl-1H-imidazole-2-carboxamide; (R)—N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)tetrahydrofuran-2-carboxamide; N1-((S)-4,4-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(3-fluorobicyclo[1.1.1]pentan-1-yl)oxalamide; N1-((2S)-3-(2,2-difluorocyclopentyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(2-fluorophenyl)oxalamide; N1-(2-fluorophenyl)-N2-((S)-1-(((S)-6-guanidino-2-oxo-1-(2,3,5,6-tetrafluorophenoxy)hexan-3-yl)amino)-4-methyl-1-oxopentan-2-yl)oxalamide; 4-methoxy-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopiperidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1H-indole-2-carboxamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)tetrahydrofuran-3-carboxamide; N1-(1-(hydroxymethyl)cyclopropyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(piperidin-4-yl)oxalamide; 4-methoxy-N-((S)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)-5-phenylpentan-2-yl)-1H-indole-2-carboxamide; N1-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(1,1-dioxidothietan-3-yl)oxalamide; (S)-2-((R)-2-((2-fluorophenyl)amino)-3-methoxypropanamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; (S)-2-((S)-2-((2-fluorophenyl)amino)-3-methoxypropanamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(1-(trifluoromethyl)cyclopropyl)oxalamide; N1-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(3-(methoxymethyl)oxetan-3-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(2-oxaspiro[3.3]heptan-6-yl)oxalamide; N1-(6,6-difluorospiro[3.3]heptan-2-yl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-3-(3-fluorophenyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(3-methoxyphenyl)oxalamide; N1-(2-fluorophenyl)-N2-((S)-3-(3-fluorophenyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(oxetan-3-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopiperidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(1-methylcyclopropyl)oxalamide; N1-(1,1-difluoro-2-methylpropan-2-yl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1,4-dioxane-2-carboxamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1H-pyrrolo[3,2-b]pyridine-2-carboxamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide; N1-((S)-3-(4-fluorophenyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(1-methylcyclopropyl)oxalamide; N1-(4-fluorobicyclo[2.2.2]octan-1-yl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(3-methylpyrrolidin-3-yl)oxalamide; 5-(2-fluoropropan-2-yl)-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)isoxazole-3-carboxamide; N1-(1-(fluoromethyl)cyclopropyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; 7-methoxy-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-2,3-dihydrobenzofuran-2-carboxamide; (1S,3aR,6aS)-2-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; N1-(2-fluorophenyl)-N2-(4-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)tetrahydro-2H-pyran-4-yl)oxalamide; (2S,4R)-1-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-4-methoxy-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pyrrolidine-2-carboxamide; 5-fluoro-N-((1R,2S)-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-2-vinylcyclopropyl)-1H-indole-2-carboxamide; (1S,3aR,6aS)-2-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; N-((1R,2R)-2-ethyl-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)cyclopropyl)-5-fluoro-1H-indole-2-carboxamide; N1-(1-(methoxymethyl)cyclopropyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1H-pyrrolo[3,2-b]pyridine-3-carboxamide; (1R,2S,5S)-3-((S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,3S,5R)-2-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-azabicyclo[3.1.0]hexane-3-carboxamide; (1S,3aR,6aS)-2-((S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; N1-(1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)-3-(tetrahydro-2H-pyran-4-yl)propan-2-yl)-N2-(2,2,2-trifluoroethyl)oxalamide; (2S,4R)-1-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-4-(trifluoromethyl)pyrrolidine-2-carboxamide; (S)-5-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-(2-((1-methylcyclopropyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; N1-(2-fluorophenyl)-N2-(1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)-3-(tetrahydro-2H-pyran-4-yl)propan-2-yl)oxalamide; (3aS,4S,6aR)-5-((S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)hexahydro-1H-furo[3,4-c]pyrrole-4-carboxamide; (1S,3aR,6aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(1-(2,2,2-trifluoroacetamido)cyclopropane-1-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(1-(2,2,2-trifluoroacetamido)cyclobutane-1-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((1S,2R)-2-methyl-1-(2,2,2-trifluoroacetamido)cyclopropane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,2S,5S)-3-((S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azaspiro[bicyclo[3.1.0]hexane-6,1′-cyclopropane]-2-carboxamide; N-((2S)-4-methyl-1-oxo-1-(((2S)-3-oxo-1-(2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-2-(trifluoromethyl)thiazole-4-carboxamide; (1S,3aR,7aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(2-(trifluoromethyl)thiazole-4-carbonyl)octahydro-1H-isoindole-1-carboxamide; (1S,3aR,7aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(5-(trifluoromethyl)isoxazole-3-carbonyl)octahydro-1H-isoindole-1-carboxamide; (2S,3aS,7aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-1-(2-oxo-2-((1,1,1-trifluoro-2-methylpropan-2-yl)amino)acetyl)octahydro-1H-indole-2-carboxamide; (1R,2S,5S)-3-((N-(2-fluorophenyl)sulfamoyl)carbonyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-3-(N-(2-fluorophenyl)sulfamoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-(5-(trifluoromethyl)isoxazole-3-carbonyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-3-(5-(2-fluoropropan-2-yl)isoxazole-3-carbonyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,2R,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-(N-(2,2,2-trifluoroacetyl)-O-(trifluoromethyl)-L-threonyl)bicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-3-(O-(difluoromethyl)-N-(2,2,2-trifluoroacetyl)-L-seryl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,2R,5S)-3-(O-(difluoromethyl)-N-(2,2,2-trifluoroacetyl)-L-threonyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)bicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-3-((S)-3-(3,3-difluoroazetidin-1-yl)-2-(2,2,2-trifluoroacetamido)propanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-(3-(2,2,2-trifluoroacetamido)cyclobutane-1-carbonyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-3-((S)-3,3-dimethyl-2-((R)-tetrahydrofuran-2-carboxamido)butanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-((R)-tetrahydrofuran-2-carbonyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((2S)-3-oxo-1-(2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-((R)-4,4,4-trifluoro-2-hydroxybutanoyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (3S,4S)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-1-(2-oxo-2-((1,1,1-trifluoro-2-methylpropan-2-yl)amino)acetyl)pyrrolidine-3-carboxamide; N-((S)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)butan-2-yl)-5-oxaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(5-oxaspiro[2.4]heptane-6-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (2R)—N-(1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)-3-(tetrahydro-2H-pyran-4-yl)propan-2-yl)tetrahydrofuran-2-carboxamide; (1S,3aR,6aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-((R)-tetrahydrofuran-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (R)—N-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)tetrahydrofuran-2-carboxamide; (R)—N-((S)-4,4-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)tetrahydrofuran-2-carboxamide; (S)—N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)tetrahydrofuran-2-carboxamide; (1R,3S,5R)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-((R)-tetrahydrofuran-2-carbonyl)-2-azabicyclo[3.1.0]hexane-3-carboxamide; (1R,3S,5R)-N-(3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-((S)-tetrahydrofuran-2-carbonyl)-2-azabicyclo[3.1.0]hexane-3-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((R)-tetrahydrofuran-2-carbonyl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((R)-1,4-dioxane-2-carbonyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-3-((S)-1,4-dioxane-2-carbonyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,3aR,6aS)-2-(7-oxabicyclo[2.2.1]heptane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-7-oxabicyclo[2.2.1]heptane-1-carboxamide; (1S,3aR,6aS)-2-(2-methyltetrahydrofuran-2-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (6S)-5-(2-methyltetrahydrofuran-2-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-(4-methyl-2-oxabicyclo[2.1.1]hexane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; 4-methyl-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-2-oxabicyclo[2.1.1]hexane-1-carboxamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-4-(2,2,2-trifluoroacetamido)-2-oxabicyclo[2.1.1]hexane-1-carboxamide; (1S,3aR,6aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(4-(trifluoromethyl)-2-oxabicyclo[2.1.1]hexane-1-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-4-(trifluoromethyl)-2-oxabicyclo[2.1.1]hexane-1-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(4-(trifluoromethyl)-2-oxabicyclo[2.1.1]hexane-1-carbonyl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-(4-(trifluoromethyl)-2-oxabicyclo[2.1.1]hexane-1-carbonyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; 4-(difluoromethyl)-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-2-oxabicyclo[2.1.1]hexane-1-carboxamide; (S)-5-(4-(difluoromethyl)-2-oxabicyclo[2.1.1]hexane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-(4-(difluoromethyl)-2-oxabicyclo[2.1.1]hexane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,2S,5S)-3-(4-(difluoromethyl)-2-oxabicyclo[2.1.1]hexane-1-carbonyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,3aR,6aS)-2-(3,3-difluorotetrahydrofuran-2-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; 3,3-difluoro-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)tetrahydrofuran-2-carboxamide; (1R,3S,5R)-N-(3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-((S)-tetrahydrofuran-2-carbonyl)-2-azabicyclo[3.1.0]hexane-3-carboxamide; (R)-3,3-dimethyl-1-oxo-1-((S)-6-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-5-azaspiro[2.4]heptan-5-yl)butan-2-yl tert-butylcarbamate; (R)-4-methyl-1-oxo-1-((S)-6-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-5-azaspiro[2.4]heptan-5-yl)pentan-2-yl tert-butylcarbamate; (R)-4-methyl-1-oxo-1-((S)-6-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-5-azaspiro[2.4]heptan-5-yl)pentan-2-yl isopropylcarbamate; (R)-4-methyl-1-oxo-1-((S)-6-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-5-azaspiro[2.4]heptan-5-yl)pentan-2-ylcyclohexylcarbamate; (R)-4-methyl-1-oxo-1-((S)-6-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-5-azaspiro[2.4]heptan-5-yl)pentan-2-ylphenylcarbamate; (R)-3,3-dimethyl-1-oxo-1-((S)-6-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-5-azaspiro[2.4]heptan-5-yl)butan-2-ylethylcarbamate; (S)-5-((R)-2-(difluoromethoxy)-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R)-2-(2-hydroxy-2-methylpropoxy)-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-((R)-2-(trifluoromethoxy)butanoyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-3-((R)-2-methoxybutanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-2-((R)-2-methoxybutanamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; (6S)-5-(2-methoxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((S)-2-methoxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2,2-dimethoxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-2-((R)-2-hydroxy-3,3-dimethylbutanamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; (S)-5-((R)-2-hydroxy-3,3-dimethylbutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((R)-2-hydroxy-3,3-dimethylbutanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-5-((S)-2-hydroxy-3,3-dimethylbutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((S)-2-hydroxy-3,3-dimethylbutanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (6S)-5-(2-hydroxy-4,4-dimethylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-(2-hydroxy-4,4-dimethylpentanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,3aR,6aS)-2-(2-hydroxy-4,4-dimethylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-5-((S)-2-hydroxy-4,4-dimethylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((S)-4-fluoro-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-(2-hydroxy-2-methylpropanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,3aR,6aS)-2-(2-hydroxy-2-methylpropanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-2-(2-hydroxy-2-methylpropanamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; (S)-5-(2-hydroxy-2-methylpropanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-2-((R)-2-hydroxy-3-methylbutanamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; (S)-5-((R)-2-hydroxy-3-methylbutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((R)-2-hydroxy-3-methylbutanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-5-((S)-2-hydroxy-3-methylbutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-((R)-2-hydroxy-3-methylbutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (6S)-5-(2-hydroxy-2,4-dimethylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((R)-2-hydroxy-4-methylpentanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-5-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-5-((S)-2-hydroxy-2-phenylpropanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R)-2-hydroxy-2-phenylpropanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(1-hydroxy-3,3-dimethylcyclobutane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((S)-2-hydroxy-2-methylbutanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-3-((R)-2-hydroxybutanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-2-((R)-2-hydroxybutanamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; (1R,2S,5S)-3-((S)-2-hydroxybutanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-5-((R)-2-hydroxybutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (2R)-2-hydroxy-N-(3-(1-methylcyclopropyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)butanamide; (2S,3aS,7aS)-1-((R)-2-hydroxybutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydro-1H-indole-2-carboxamide; (2S,3aS,6aS)-1-((R)-2-hydroxybutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[b]pyrrole-2-carboxamide; (R)-2-hydroxy-N-((R)-3-(1-methylcyclopropyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)butanamide; (R)-2-hydroxy-N-((S)-3-(1-methylcyclopropyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)butanamide; (1S,3aR,6aS)-2-((R)-2-hydroxybutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,2S,5S)-3-((R)-2-hydroxypentanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,3aR,6aS)-2-((2R,3R)-2-hydroxy-3-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-5-((2R,3R)-2-hydroxy-3-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R)-2-methoxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((R)-2-hydroxy-2-(2-methoxyphenyl)acetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (6S)-5-(2-hydroxy-2-(1-methyl-1H-imidazol-5-yl)acetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-((S)-3,3,3-trifluoro-2-hydroxypropanamido)pentanamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((S)-3,3,3-trifluoro-2-hydroxypropanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-((S)-3,3,3-trifluoro-2-hydroxypropanoyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((R)-3,3,3-trifluoro-2-hydroxypropanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (6S)-5-(2-(1,1-dioxidetetrahydro-2H-thiopyran-4-yl)-2-hydroxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (6S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(5,5,5-trifluoro-2-hydroxy-4-(trifluoromethyl)pentanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (6S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(4,4,4-trifluoro-2-hydroxybutanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-(4,4,4-trifluoro-2-hydroxybutanoyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-5-((R)-3-cyclopropyl-2-hydroxypropanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-((R)-3-cyclopropyl-2-hydroxypropanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,2S,5S)-3-((S)-3-cyclopropyl-2-hydroxypropanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (6S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(5,5,5-trifluoro-2-hydroxypentanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-2-((S)-3-fluoro-2-hydroxypropanamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; (S)-5-((S)-3-fluoro-2-hydroxypropanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R)-2-hydroxy-3-phenylpropanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (6S)-5-(2-hydroxy-2-(3,4,5-trifluorophenyl)acetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (6S)-5-(2-(3,4-difluorophenyl)-2-hydroxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-(2-(3,4-difluorophenyl)-2-hydroxyacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (6S)-5-(2-(2,4-difluorophenyl)-2-hydroxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R)-2-(4-fluorophenyl)-2-hydroxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-((R)-2-(4-fluorophenyl)-2-hydroxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (6S)-5-(2-(3-fluorophenyl)-2-hydroxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (6S)-5-(2-hydroxy-2-(2-(trifluoromethyl)phenyl)acetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((R)-2-(2-fluorophenyl)-2-hydroxyacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-2-((R)-2-(2-fluorophenyl)-2-hydroxyacetamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; (1S,3aR,6aS)-2-((R)-2-(2-fluorophenyl)-2-hydroxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-5-((R)-2-(2-fluorophenyl)-2-hydroxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((S)-2-(2-fluorophenyl)-2-hydroxyacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-5-((R)-2-hydroxy-2-phenylacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((R)-2-hydroxy-2-phenylacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,3aR,6aS)-2-((R)-2-hydroxy-2-phenylacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-5-((S)-2-hydroxy-2-phenylacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((S)-2-hydroxy-2-phenylacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,3aR,6aS)-2-((S)-2-hydroxy-2-phenylacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (6S)-5-(2-hydroxy-2-(pyridin-2-yl)acetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (6S)-5-(2-hydroxy-2-(pyridin-3-yl)acetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(1-hydroxycyclopropane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(4,4-difluoro-1-hydroxycyclohexane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(1-hydroxycyclobutane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(1-hydroxycyclopentane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(1-hydroxycyclohexane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-((R)-2-hydroxypentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((2R,4R)-5,5,5-trifluoro-2-hydroxy-4-methylpentanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((2R,4S)-5,5,5-trifluoro-2-hydroxy-4-methylpentanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(4-methyl-2-oxopentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(4-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R)-3-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((S)-3-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; Methyl ((S)-3,3-dimethyl-1-oxo-1-((S)-6-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-5-azaspiro[2.4]heptan-5-yl)butan-2-yl)carbamate; (S)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(2-((1-(trifluoromethyl)cyclopropyl)amino)acetamido)pentanamide; (S)-5-((methylcarbamoyl)-D-leucyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((S)-2-acetamido-3,3-dimethylbutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((2-fluorobenzoyl)glycyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; tert-butyl ((R)-1-((1R,2S,5S)-6,6-dimethyl-2-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-3-azabicyclo[3.1.0]hexan-3-yl)-1-oxobutan-2-yl)carbamate; (1R,2S,5S)-3-((R)-2-aminobutanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,3aR,6aS)-2-(methylprolyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-5-((S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-(3-(4,4-difluoropiperidin-1-yl)-2-(2,2,2-trifluoroacetamido)propanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-5-((S)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-(2-(2-chlorophenyl)-2-hydroxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; cyclopropyl((S)-1-((1R,2S,5S)-6,6-dimethyl-2-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-3-azabicyclo[3.1.0]hexan-3-yl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate; (S)-5-(2-ethylbutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,3S,5R)-2-((R)-2-hydroxy-4-methylpentanoyl)-5-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-azabicyclo[3.1.0]hexane-3-carboxamide; (S)-5-((R)-4,4-difluoro-2-hydroxybutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-((R)-4,4-difluoro-2-hydroxybutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3S,5R)-2-((R)-2-hydroxy-3-methylbutanoyl)-5-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-azabicyclo[3.1.0]hexane-3-carboxamide; (S)-5-(4-(tert-butyl)benzoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((R)-2-hydroxy-4,4-dimethylpentanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-5-(2-(3-(tert-butyl)phenyl)-2-methylpropanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-methyl-2-(3-(trifluoromethyl)phenyl)propanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(3-(trifluoromethyl)benzoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(3-(tert-butyl)benzoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(4,4-dimethylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; 5-(2-fluorophenyl)-N-((S)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)-3-phenylpropan-2-yl)isoxazole-3-carboxamide; N-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-5-(phenylamino)-1,3,4-oxadiazole-2-carboxamide; 5-benzyl-N-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)isoxazole-3-carboxamide; (S)-4-methyl-2-((1-methyl-1H-indole)-5-sulfonamido)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-5-(pyridin-2-yl)isoxazole-3-carboxamide; (S)-4-methyl-2-((2-oxo-1,2-dihydroquinolin-3-yl)amino)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; 7-methoxy-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)benzofuran-2-carboxamide; (1S,3aR,6aS)-2-(2-(cyclohexylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-(2-(trifluoromethyl)thiazole-4-carbonyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-6,6-dimethyl-3-(2-((1-methylcyclopropyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-3-(2-(cyclohexylamino)-2-oxoacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopiperidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-3-(2-(tert-butylamino)-2-oxoacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(2-oxo-2-((1,1,1-trifluoro-2-methylpropan-2-yl)amino)acetyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-(2-oxo-2-(o-tolylamino)acetyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-(2-oxo-2-((1-(trifluoromethyl)cyclopropyl)amino)acetyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,3aR,6aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(2-(trifluoromethyl)thiazole-4-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,2S,5S)-3-(2-((3,3-difluorocyclobutyl)amino)-2-oxoacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-3-(5-(2-fluoropropan-2-yl)isoxazole-3-carbonyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (6S)-1,1-difluoro-5-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(5-(trifluoromethyl)isoxazole-3-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,2S,5S)-3-(2-((2,2-difluoropropyl)amino)-2-oxoacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-3-(2-((3-fluorobicyclo[1.1.1]pentan-1-yl)amino)-2-oxoacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (3S,4aS,8aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(2-oxo-2-((1,1,1-trifluoro-2-methylpropan-2-yl)amino)acetyl)decahydroisoquinoline-3-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-(3-(trifluoromethyl)isoxazole-5-carbonyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-3-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; N-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-5-(2-fluoropropan-2-yl)isoxazole-3-carboxamide; (1S,3aR,6aS)-2-(5-(2-fluoropropan-2-yl)isoxazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((R)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-(3-(trifluoromethyl)isoxazole-5-carbonyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,2S,5R)-3-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,3aR,6aS)-2-(2-((1-methylcyclopropyl)amino)-2-oxoacetyl)-N-((R)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(2-(tert-butylamino)-2-oxoacetyl)-N-((R)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(2-(cyclopropylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (2S,3aS,7aS)-1-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydro-1H-indole-2-carboxamide; 5-(2-fluoropropan-2-yl)-N-(1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)-3-(tetrahydro-2H-pyran-4-yl)propan-2-yl)isoxazole-3-carboxamide; (1S,3aR,6aS)-2-(5-(difluoromethyl)isoxazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,2S)-3-(5-(2-fluoropropan-2-yl)isoxazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hex-4-ene-2-carboxamide; (S)-5-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; N1-(tert-butyl)-N2-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)oxalamide; N1-((S)-4,4-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(o-tolyl)oxalamide; N1-((S)-4,4-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(2,2,2-trifluoroethyl)oxalamide; N1-(3-fluorobicyclo[1.1.1]pentan-1-yl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(o-tolyl)oxalamide; 6-(2-(tert-butylamino)-2-oxoacetyl)-2,2-difluoro-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-6-azaspiro[3.4]octane-7-carboxamide; N1-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(3-fluorobicyclo[1.1.1]pentan-1-yl)oxalamide; N1-(3-fluorobicyclo[1.1.1]pentan-1-yl)-N2-(1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)-3-(tetrahydro-2H-pyran-4-yl)propan-2-yl)oxalamide; 6-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-6-azaspiro[3.4]octane-7-carboxamide; N1-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(1-(trifluoromethyl)cyclopropyl)oxalamide; (1S,3aR,6aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(2-oxo-2-(o-tolylamino)acetyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (R)-6-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-oxa-6-azaspiro[3.4]octane-7-carboxamide; (S)-6-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-oxa-6-azaspiro[3.4]octane-7-carboxamide; (1R,2S,5S)-3-(2-((2,2-difluoroethyl)amino)-2-oxoacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; N1-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(2,2,2-trifluoroethyl)oxalamide; (3R,6S)-5-(2-(tert-butylamino)-2-oxoacetyl)-1,1-difluoro-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-(2-((2,2-difluoroethyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(2-(tert-butylamino)-2-oxoacetyl)-5,5-difluoro-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,3S,5R)-2-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-azabicyclo[3.1.0]hexane-3-carboxamide; 2-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-8-oxa-2-azaspiro[4.5]decane-3-carboxamide; (1S,3aR,6aS)-2-(2-((3,3-difluorocyclobutyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; N1-(1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)-3-(tetrahydro-2H-pyran-4-yl)propan-2-yl)-N2-(o-tolyl)oxalamide; (1S,3aR,6aS)-2-(2-((3-fluorobicyclo[1.1.1]pentan-1-yl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(2-oxo-2-((1,1,1-trifluoro-2-methylpropan-2-yl)amino)acetyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(2-oxo-2-(o-tolylamino)acetyl)-5-azaspiro[2.4]heptane-6-carboxamide; N1-((S)-4,4-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(2-fluorophenyl)oxalamide; N1-(tert-butyl)-N2-((S)-1-cyclopentyl-2-oxo-2-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)ethyl)-N2-methyloxalamide; 2-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-8-oxa-2-azaspiro[4.5]decane-3-carboxamide; 2-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-azaspiro[4.5]decane-3-carboxamide; 5-(difluoromethyl)-N-((S)-4,4-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)isoxazole-3-carboxamide; (1S,3aR,6aS)-2-(1-methyl-1H-pyrazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(2-((1-methyl-1H-pyrazol-3-yl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,2S,5S)-6,6-dimethyl-3-(2-((1-methyl-1H-pyrazol-3-yl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-3-(2-((3,3-difluorocyclobutyl)amino)-2-oxoacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (2S,4R)-1-(2-(tert-butylamino)-2-oxoacetyl)-4-methoxy-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pyrrolidine-2-carboxamide; N-((S)-4,4-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-2-(trifluoromethyl)thiazole-5-carboxamide; (1S,3S,5S)-2-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-azabicyclo[3.1.0]hexane-3-carboxamide; (S)-4,4-dimethyl-1-(2-((1-methylcyclopropyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pyrrolidine-2-carboxamide; (S)-4-(2-((1-methylcyclopropyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-4-azaspiro[2.4]heptane-5-carboxamide; (1R,3S,4S)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(2-oxo-2-((2,2,2-trifluoroethyl)amino)acetyl)-2-azabicyclo[2.2.1]heptane-3-carboxamide; (S)-1-(2-((3,3-difluorocyclobutyl)amino)-2-oxoacetyl)-4,4-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pyrrolidine-2-carboxamide; (1S,3aR,6aS)-2-(2-morpholino-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(5-methylisoxazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3S,4R)-2-(2-((1-methylcyclopropyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-azabicyclo[2.2.1]heptane-3-carboxamide; (2R,3aS,5R,6aS)-4-(2-(tert-butylamino)-2-oxoacetyl)-2-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)hexahydro-2H-furo[3,2-b]pyrrole-5-carboxamide; (1S,3aR,6aS)-2-(2-(((1R,5S,6r)-3-oxabicyclo[3.1.0]hexan-6-yl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(6,7-dihydro-4H-pyrano[3,4-d]isoxazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(2-((3-methylpyridin-2-yl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (2R,3aS,5S,6aS)-4-(2-(tert-butylamino)-2-oxoacetyl)-2-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)hexahydro-2H-furo[3,2-b]pyrrole-5-carboxamide; 1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N-(o-tolyl)-1H-1,2,3-triazole-4-carboxamide; (1R,2S,5S)-3-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azaspiro[bicyclo[3.1.0]hexane-6,1′-cyclopropane]-2-carboxamide; (1S,3aR,6aS)-2-(2-((1,1-difluoro-2-methylpropan-2-yl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,2S,5S)-3-(2-((1,1-difluoro-2-methylpropan-2-yl)amino)-2-oxoacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,3aR,6aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(benzo[d]isoxazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-6-(2-((1-methylcyclopropyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-6-azaspiro[3.4]octane-7-carboxamide; Tetrahydrofuran-3-yl(1S,3aR,6aS)-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)hexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate; (1s,4R)-2-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-azabicyclo[2.1.1]hexane-1-carboxamide; (1S,2S,5R)-3-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.2.0]heptane-2-carboxamide; (1s,4R)-2-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-azabicyclo[2.1.1]hexane-1-carboxamide; (1S,2S,5R)-3-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.2.0]heptane-2-carboxamide; N1-((S)-5,5-difluoro-4,4-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(3-fluorobicyclo[1.1.1]pentan-1-yl)oxalamide; N1-((S)-3-cyclobutyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(3-fluorobicyclo[1.1.1]pentan-1-yl)oxalamide; (1S,3aR,6aS)-2-(2-((2-cyanopropan-2-yl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (R)-1-(2-(tert-butylamino)-2-oxoacetyl)-2-(cyclopropylmethyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pyrrolidine-2-carboxamide; (S)-5-(5,5-dimethyl-4,5,6,7-tetrahydrobenzo[d]isoxazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; Methyl 2-oxo-2-((1S,3aR,6aS)-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)acetate; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(2-oxo-2-((2,2,2-trifluoroethyl)amino)acetyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-((1-methylcyclopropyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(5-(difluoromethyl)isoxazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; N1-(3-fluorobicyclo[1.1.1]pentan-1-yl)-N2-((S)-3-(1-methylcyclobutyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)oxalamide; (1S,3aR,6aS)-2-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-(2-oxo-1,2-dihydropyridin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-5-(2-((2-methoxyphenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(2-oxo-2-((2-(trifluoromethyl)phenyl)amino)acetyl)-5-azaspiro[2.4]heptane-6-carboxamide; N1-(1-methylcyclopropyl)-N2-(3-(1-methylcyclopropyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)oxalamide; N1-cyclopropyl-N2-(3-(1-methylcyclopropyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)oxalamide; N1-(3-fluorobicyclo[1.1.1]pentan-1-yl)-N2-((1S,2R)-2-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-[1,1′-bi(cyclopropane)]-2-yl)oxalamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1,2,4-oxadiazole-3-carboxamide; (1R,3S,5R)-2-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-5-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-azabicyclo[3.1.0]hexane-3-carboxamide; N1-(3-fluorobicyclo[1.1.1]pentan-1-yl)-N2-((S)-3-(1-methylcyclopropyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)oxalamide; (S)-1-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)azetidine-2-carboxamide; (S)-1-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)azepane-2-carboxamide; N1-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(1-methylcyclopropyl)oxalamide; N1-cyclopropyl-N2-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)oxalamide; (R)-5-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-((3,3-difluorocyclobutyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; N1-((S)-3-(3,4-difluorophenyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(2-fluorophenyl)oxalamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(2-oxo-2-((1,1,1-trifluoro-2-methylpropan-2-yl)amino)acetyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-((4-chloro-2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; N-(tert-butyl)-1-(4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1H-1,2,3-triazole-4-carboxamide; (S)-5-(3-fluoropicolinoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-(3,5-difluoro-2-hydroxybenzoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-5-((S)-3-hydroxy-2-phenylpropanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(3-(trifluoromethyl)bicyclo[1.1.1]pentan-1-yl)oxalamide; (S)-5-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-4,4,6-d3-6-carboxamide; (S)-5-(2-((2,3-difluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-((2-fluoro-3-methoxyphenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-((2-fluoro-3-(trifluoromethoxy)phenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-(2-(tert-butylamino)-2-oxoacetyl)-4-fluoro-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-5-(2-((2,5-difluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-((2-chloro-6-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-(5-fluoro-1H-indole-2-carbonyl)-N-((R)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-5-(4-methoxy-1H-indole-2-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-((2-chlorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-((3-chlorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(6-chlorobenzo[d]isoxazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(2-oxo-2-((2-(trifluoromethoxy)phenyl)amino)acetyl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-(6-fluorobenzo[d]isoxazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1,3,3-d3-1-carboxamide; (S)-5-(2-((2-(tert-butyl)phenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-(5-fluorobenzo[d]isoxazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(2-((2-(tert-butyl)phenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-5-(2,2-difluoro-2-phenylacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(L-leucyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-pentanoyl-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-methyl-2-phenylpropanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; benzyl ((S)-1-((1R,2S,5S)-6,6-dimethyl-2-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-3-azabicyclo[3.1.0]hexan-3-yl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate; (1S,3aR,6aS)-2-(2-(6-chloropyrazin-2-yl)-2-methoxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (R)-1-(2-fluorophenyl)-2-oxo-2-((1S,3aR,6aS)-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)ethyl 2-phenylacetate; (S)-5-(2,2-difluoro-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(4-fluoro-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(2,2,4-trimethylpentanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (R)-4-methyl-1-oxo-1-((S)-6-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-5-azaspiro[2.4]heptan-5-yl)pentan-2-ylpropionate; (S)-5-(3-fluorobicyclo[1.1.1]pentane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((S)-2-phenylpropanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-((S)-2-phenylpropanoyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-3-(4,4-difluoro-1-hydroxycyclohexane-1-carbonyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (R)-4-methyl-1-oxo-1-((S)-6-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-5-azaspiro[2.4]heptan-5-yl)pentan-2-yl isobutyrate; (R)-4-methyl-1-oxo-1-((S)-6-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-5-azaspiro[2.4]heptan-5-yl)pentan-2-yl 2-phenylacetate; (S)-5-(1-hydroxy-4,4-dimethylcyclohexane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((S)-2-(3-cyclopropylureido)-3,3-dimethylbutanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-5-(2,2-difluoroacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-1-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)piperidine-2-carboxamide; (2S,4R)-4-(tert-butyl)-1-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)piperidine-2-carboxamide; (1R,2S,5S)-3-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.2.1]octane-2-carboxamide; (S)-1-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)azepane-2-carboxamide; (S)-6-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-6-azaspiro[2.5]octane-5-carboxamide; (S)-1-((R)-2-hydroxy-4-methylpentanoyl)-4,4-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)piperidine-2-carboxamide; (S)-2-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-azabicyclo[2.2.2]octane-3-carboxamide; tert-butyl ((R)-4-methyl-1-oxo-1-((S)-6-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-5-azaspiro[2.4]heptan-5-yl)pentan-2-yl)carbamate; (S)-5-(D-leucyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; tert-butyl methyl ((R)-4-methyl-1-oxo-1-((S)-6-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-5-azaspiro[2.4]heptan-5-yl)pentan-2-yl)carbamate; (S)-5-(4,4-difluoro-1-methoxycyclohexane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-isopropoxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(2-phenylacetyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(1-hydroxy-4-(trifluoromethyl)cyclohexane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-3-((S)-2-(2-((2-fluorophenyl)amino)-2-oxoacetamido)-4-methylpentanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butylmethyl(phenyl)phosphinate; 4-fluoro-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-1H-indole-2-carboxamide; (S)-3-((S)-4-methyl-2-(2-oxo-2-(phenylamino)acetamido)pentanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butylmethyl(phenyl)phosphinate; N1-(2-fluorophenyl)-N2-((S)-4-methyl-1-(((S)-5-(methylthio)-2-oxo-1-(2,3,5,6-tetrafluorophenoxy)pentan-3-yl)amino)-1-oxopentan-2-yl)oxalamide; N1-(2-fluorophenyl)-N2-((S)-4-methyl-1-(((S)-5-(methylsulfonyl)-2-oxo-1-(2,3,5,6-tetrafluorophenoxy)pentan-3-yl)amino)-1-oxopentan-2-yl)oxalamide; (1S,3aR,6aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(2-oxo-2-((1-(trifluoromethyl)cyclopropyl)amino)acetyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; 2-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-azaspiro[4.4]nonane-3-carboxamide; (S)-5-((R)-2-hydroxy-4,4-dimethylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-(5-chlorobenzo[d]isoxazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-5-(methyl-D-leucyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(4,4-difluorocyclohexane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R)-2-hydroxypent-4-enoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(7-chloro-1H-indole-2-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-acetyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-pivaloyl-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R,E)-2-hydroxy-5-(4-methoxyphenyl)pent-4-enoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R,E)-5-(4-fluorophenyl)-2-hydroxypent-4-enoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R)-2-hydroxy-4-methylpentanoyl)-N-((R)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((N-phenylsulfamoyl)glycyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(3-((N-phenylsulfamoyl)amino)propanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (R)—N-((S)-3-(3-fluorophenyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-2-hydroxy-4-methylpentanamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((2,2,2-trifluoroethyl)glycyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(2-(2,2,2-trifluoroethoxy)acetyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(2-oxo-2-phenylacetyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R,E)-2-hydroxy-6-(methylsulfonamido)hex-4-enoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-(methylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; N1-((S)-3-(3-fluorophenyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-methyloxalamide; (S)-5-(4,4-difluoropentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((S)-tetrahydrofuran-2-carbonyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(4,4-difluoro-1-(2,2,2-trifluoroacetamido)cyclohexane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (6S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(3,3,3-trifluoro-2-hydroxy-2-phenylpropanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(tetrahydro-2H-pyran-4-carbonyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(4,4-difluorobutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(3,3,4,4-tetrafluorobutanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (2S,4R)-1-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-4-(trifluoromethyl)pyrrolidine-2-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(2-(trifluoromethyl)benzoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2,2-difluorobenzo[d][1,3]dioxole-5-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-propionyl-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(but-3-enoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(pent-4-enoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((N-methylsulfamoyl)glycyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((N,N-dimethylsulfamoyl)glycyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(N-(N,N-dimethylsulfamoyl)-N-methylglycyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-benzoyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(1-isobutyl-1H-1,2,3-triazole-4-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-1-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pyrrolidine-2-carboxamide; (S)-5-((R)-2-hydroxypropanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-hydroxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(3,5-difluorobenzoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((S)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-(3,3-difluorocyclobutyl)acetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(4-chloro-2-fluorobenzoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(2,2,2-trifluoroacetyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-Isobutyryl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-butyryl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R)-2-hydroxy-4-(methyl-13C)pentanoyl-1,2,3,4,5-13C5)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(3-methylbutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-hexanoyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-2-acetamido-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; (S)-5-(2,4-difluorobenzoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-(1-methylcyclopentyl)acetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(3,3-difluoro-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(3,3,4,4-tetrafluoropentanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2,2-difluoro-3-methylbutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((R)-2-hydroxy-2-phenylacetyl)-6,6-dimethyl-N-((R)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((R)-2-(trifluoromethoxy)butanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(3-hydroxy-3-methylbutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((1R,2R)-2-(trifluoromethyl)cyclopropane-1-carbonyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-2-hydroxy-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; (6S)-5-(3,3-difluorocyclopentane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(3,3-difluorocyclobutane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(cyclopentanecarbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (2S,4R)-1-acetyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-4-(trifluoromethyl)pyrrolidine-2-carboxamide; (S)-5-((E)-4-methylpent-2-enoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((2R,3S)-2,3-dihydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R)-2-hydroxy-4-methylpentanoyl)-N-((R)-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((S)-2-hydroxy-4-methylpentanoyl)-N-((R)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((S)-2-hydroxy-4-methylpentanoyl)-N-((R)-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((S)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((R)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(pentanoyl-d9)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(hexanoyl-d11)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(4-(methyl-d3)pentanoyl-2,2,3,3,4,5,5,5-d8)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-fluoro-2-methylpropanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(butanoyl-d7)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(3-(methyl-d3)butanoyl-2,2,3,4,4,4-d6)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-methylpropanoyl-2-d)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-(methyl-d3)propanoyl-3,3,3-d3)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(hexanoyl-2,2-d2)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((R)-2-(2-fluoro-3-methoxyphenyl)-2-hydroxyacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; N1-((S)-1-(((S)-4-hydroxy-3-oxo-1-((S)-2-oxopiperidin-3-yl)butan-2-yl)amino)-4,4-dimethyl-1-oxopentan-2-yl)-N2-(6-(trifluoromethyl)pyridin-2-yl)oxalamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(5,5,5-trifluoro-2-oxo-4-(trifluoromethyl)pentanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((R)-5,5,5-trifluoro-2-hydroxy-4-(trifluoromethyl)pentanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((S)-5,5,5-trifluoro-2-hydroxy-4-(trifluoromethyl)pentanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-(cyclopropylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-(isopropylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((S)-2,4-dimethylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-(ethylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (R)-5-(4,4-difluoropentanoyl)-N-((R)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-4,4-difluoro-1-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pyrrolidine-2-carboxamide; (S)-5-((R)-2,4-dimethylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (2S,4R)-1-((R)-2-hydroxy-4-methylpentanoyl)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pyrrolidine-2-carboxamide; (S)-5-((R)-4-fluoro-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(hexanoyl-5,5,6,6,6-d5)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (6S)-5-(2,2-difluoro-3-hydroxybutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(hexanoyl-6,6,6-d3)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (6S)-5-(2-methoxybutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(acetyl-d3)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R)-2-cyclobutyl-2-hydroxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (2S,4S)-1-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-4-phenylpyrrolidine-2-carboxamide; (6S)-5-(3-fluoro-2-hydroxy-3-methylbutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(pentanoyl-5,5,5-d3)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(butanoyl-4,4,4-d3)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-4-methyl-2-((1-methyl-1H-indole)-5-sulfonamido)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)pentanamide; (S)-5-((R)-2-hydroxypentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (R)-2-hydroxy-4-methyl-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)pentanamide; 1-((S)-2-hydroxy-2-phenylacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)azepane-2-carboxamide; 1-((S)-2-hydroxy-2-phenylacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)piperidine-2-carboxamide; 6-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-6-azaspiro[3.4]octane-7-carboxamide; (2S)-4-(bicyclo[1.1.1]pentan-2-yl)-1-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pyrrolidine-2-carboxamide; (2S,4S)-4-(cyclobutylmethyl)-1-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pyrrolidine-2-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(2-(4-(trifluoromethoxy)phenoxy)acetyl)-5-azaspiro[2.4]heptane-6-carboxamide; (6S)-5-(4-methyl-2-nitrosopentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (2S,4R)-1-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-4-(trifluoromethyl)pyrrolidine-2-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(1H-pyrrolo[2,3-b]pyridine-2-carbonyl)-5-azaspiro[2.4]heptane-6-carboxamide; 2-((4-fluorophenyl)amino)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)acetamide; (2S,4S)-1-(2-fluoro-2-methylpropanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-4-phenylpyrrolidine-2-carboxamide; (S)-5-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopiperidin-3-yl)-4-(perfluorophenoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (2S,4S)-1-((S)-2-hydroxy-2-phenylacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-4-phenylpyrrolidine-2-carboxamide; (S)-5-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopiperidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopiperidin-3-yl)-4-(2,3,6-trifluorophenoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-(6-chlorobenzo[d]isoxazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; 4-fluoro-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-1H-indole-2-carboxamide; (2S,4R)-1-((S)-2-hydroxy-2-phenylacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-4-(trifluoromethyl)pyrrolidine-2-carboxamide; (2S,4S)-1-((R)-2-hydroxy-2-phenylacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-4-phenylpyrrolidine-2-carboxamide; (S)-1-((R)-2-hydroxy-4-methylpentanoyl)-5,5-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pyrrolidine-2-carboxamide; N1-(2-fluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-((2-(trifluoromethyl)pyrimidin-4-yl)oxy)butan-2-yl)amino)pentan-2-yl)oxalamide; and 3. The compound of claim 1 or claim 2, or a pharmaceutically acceptable salt thereof, selected from the group consisting of N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-5-oxaspiro[2.4]heptane-6-carboxamide.

36. The compound is 4-methoxy-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1H-indole-2-carboxamide; (S)-5-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; N1-(2-fluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(2-fluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; (R)-3,3-dimethyl-1-oxo-1-((S)-6-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-5-azaspiro[2.4]heptan-5-yl)butan-2-ylethylcarbamate; (S)-5-(4-methyl-2-oxopentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; N1-(3-fluorobicyclo[1.1.1]pentan-1-yl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; (1S,3aR,6aS)-2-(2-((3,3-difluorocyclobutyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; N-((S)-3-cyclohexyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)-1H-indole-2-carboxamide; 4-fluoro-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-1H-indole-2-carboxamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-phenyloxalamide; N1-(2-fluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)propan-2-yl)-N2-phenyloxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-(2-(trifluoromethyl)phenyl)oxalamide; N1-(2-fluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-N2-(tetrahydro-2H-pyran-4-yl)oxalamide; 2,2-difluoro-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)benzo[d][1,3]dioxole-5-carboxamide; N1-cyclohexyl-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(tert-butyl)-N2-((S)-4,4-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-cyclopropyl-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(3,3-difluorocyclobutyl)oxalamide; 5-(2-fluorophenyl)-N-((S)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)-3-phenylpropan-2-yl)isoxazole-3-carboxamide; 5-(2-fluorophenyl)-N-(1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)-3-(tetrahydro-2H-pyran-4-yl)propan-2-yl)isoxazole-3-carboxamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(2,2,2-trifluoroethyl)oxalamide; N-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)benzo[d]oxazole-2-carboxamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)imidazo[1,2-b]pyridazine-2-carboxamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(o-tolyl)oxalamide; N1-(2-fluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopiperidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; (R)—N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)tetrahydrofuran-2-carboxamide; N1-((S)-4,4-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(3-fluorobicyclo[1.1.1]pentan-1-yl)oxalamide; N1-(1,1-difluoro-2-methylpropan-2-yl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1,4-dioxane-2-carboxamide; 5-(2-fluoropropan-2-yl)-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)isoxazole-3-carboxamide; N1-(1-(fluoromethyl)cyclopropyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; (1S,3aR,6aS)-2-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,2S,5S)-3-((S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,3aR,6aS)-2-((S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-(2-(trifluoromethyl)thiazole-4-carbonyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-6,6-dimethyl-3-(2-((1-methylcyclopropyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-3-(2-(cyclohexylamino)-2-oxoacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopiperidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-3-(2-(tert-butylamino)-2-oxoacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-(2-oxo-2-(o-tolylamino)acetyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-(5-(trifluoromethyl)isoxazole-3-carbonyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-(2-oxo-2-((1-(trifluoromethyl)cyclopropyl)amino)acetyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,3aR,6aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(2-(trifluoromethyl)thiazole-4-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-((R)-tetrahydrofuran-2-carbonyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-3-(5-(2-fluoropropan-2-yl)isoxazole-3-carbonyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-5-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; N1-(2-fluorophenyl)-N2-(1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)-3-(tetrahydro-2H-pyran-4-yl)propan-2-yl)oxalamide; (1S,3aR,6aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(5-(trifluoromethyl)isoxazole-3-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,2S,5S)-3-(2-((3-fluorobicyclo[1.1.1]pentan-1-yl)amino)-2-oxoacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-3-((R)-2-hydroxybutanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-(3-(trifluoromethyl)isoxazole-5-carbonyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; N-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-5-(2-fluoropropan-2-yl)isoxazole-3-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((R)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-(3-(trifluoromethyl)isoxazole-5-carbonyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,3aR,6aS)-2-(2-((1-methylcyclopropyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(5-(difluoromethyl)isoxazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-5-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; N1-(tert-butyl)-N2-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)oxalamide; N1-(3-fluorobicyclo[1.1.1]pentan-1-yl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; 6-(2-(tert-butylamino)-2-oxoacetyl)-2,2-difluoro-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-6-azaspiro[3.4]octane-7-carboxamide; N1-((S)-3-cyclopropyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(3-fluorobicyclo[1.1.1]pentan-1-yl)oxalamide; (1R,2S,5S)-3-(2-hydroxy-2-methylpropanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (3R,6S)-5-(2-(tert-butylamino)-2-oxoacetyl)-1,1-difluoro-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-(2-(tert-butylamino)-2-oxoacetyl)-5,5-difluoro-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-((R)-tetrahydrofuran-2-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(2-((3,3-difluorocyclobutyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(2-((3-fluorobicyclo[1.1.1]pentan-1-yl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(2-oxo-2-(o-tolylamino)acetyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azaspiro[bicyclo[3.1.0]hexane-6,1′-cyclopropane]-2-carboxamide; (1R,2S,5S)-3-((R)-2-(2-fluorophenyl)-2-hydroxyacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,3aR,6aS)-2-(benzo[d]isoxazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-2-((R)-2-hydroxybutanamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; (1R,2S,5S)-3-((R)-2-methoxybutanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-((R)-2-(trifluoromethoxy)butanoyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; N1-((S)-5,5-difluoro-4,4-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(3-fluorobicyclo[1.1.1]pentan-1-yl)oxalamide; (1S,3aR,6aS)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-(4-(trifluoromethyl)-2-oxabicyclo[2.1.1]hexane-1-carbonyl)octahydrocyclopenta[c]pyrrole-1-carboxamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-4-(trifluoromethyl)-2-oxabicyclo[2.1.1]hexane-1-carboxamide; (S)-2-((R)-2-(2-fluorophenyl)-2-hydroxyacetamido)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; N1-((S)-3-cyclobutyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-N2-(3-fluorobicyclo[1.1.1]pentan-1-yl)oxalamide; (S)-4-methyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-2-((S)-3,3,3-trifluoro-2-hydroxypropanamido)pentanamide; (1S,3aR,6aS)-2-((R)-2-(2-fluorophenyl)-2-hydroxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((S)-3,3,3-trifluoro-2-hydroxypropanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-(7-oxabicyclo[2.2.1]heptane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(2-oxo-2-((2,2,2-trifluoroethyl)amino)acetyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-((1-methylcyclopropyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; N1-(3-fluorobicyclo[1.1.1]pentan-1-yl)-N2-((S)-3-(1-methylcyclobutyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)oxalamide; (S)-5-((R)-2-(2-fluorophenyl)-2-hydroxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(2-oxo-2-((2-(trifluoromethyl)phenyl)amino)acetyl)-5-azaspiro[2.4]heptane-6-carboxamide; N1-(1-methylcyclopropyl)-N2-(3-(1-methylcyclopropyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)oxalamide; N1-cyclopropyl-N2-(3-(1-methylcyclopropyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)oxalamide; (1R,2S,5S)-3-((R)-2-hydroxy-4-methylpentanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-3-((R)-2-hydroxy-3-methylbutanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-5-((R)-2-hydroxybutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((R)-3,3,3-trifluoro-2-hydroxypropanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(4-(trifluoromethyl)-2-oxabicyclo[2.1.1]hexane-1-carbonyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((S)-2-hydroxy-3,3-dimethylbutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((S)-2-hydroxy-3,3-dimethylbutanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,3aR,6aS)-2-((R)-3-cyclopropyl-2-hydroxypropanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (6S)-5-(2-(3,4-difluorophenyl)-2-hydroxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((S)-2-hydroxy-2-phenylpropanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(1-hydroxycyclopentane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((R)-2-hydroxypentanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (6S)-5-(2-(2,4-difluorophenyl)-2-hydroxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((S)-2-(2-fluorophenyl)-2-hydroxyacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-5-(1-hydroxycyclohexane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-4,4,6-d3-6-carboxamide; (1R,2S,5S)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-(4-(trifluoromethyl)-2-oxabicyclo[2.1.1]hexane-1-carbonyl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (6S)-5-(2-hydroxy-4,4-dimethylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-(2-hydroxy-4,4-dimethylpentanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (6S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(4,4,4-trifluoro-2-hydroxybutanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-((R)-2-hydroxy-3-methylbutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-5-((R)-2-(4-fluorophenyl)-2-hydroxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-((R)-2-(4-fluorophenyl)-2-hydroxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (6S)-5-(2-(3-fluorophenyl)-2-hydroxyacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((R)-2-hydroxy-2-phenylacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1S,3aR,6aS)-2-((R)-2-hydroxy-2-phenylacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(2-hydroxy-4,4-dimethylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(5-fluoro-1H-indole-2-carbonyl)-N-((R)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (R)-4-methyl-1-oxo-1-((S)-6-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-5-azaspiro[2.4]heptan-5-yl)pentan-2-ylcyclohexylcarbamate; (R)-4-methyl-1-oxo-1-((S)-6-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-5-azaspiro[2.4]heptan-5-yl)pentan-2-yl isopropylcarbamate; (S)-5-(2-((2-chlorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(4,4-difluoro-1-hydroxycyclohexane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((S)-4-fluoro-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (R)-4-methyl-1-oxo-1-((S)-6-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-5-azaspiro[2.4]heptan-5-yl)pentan-2-yl tert-butylcarbamate; (S)-5-((R)-2-(difluoromethoxy)-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R)-2-hydroxy-4,4-dimethylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-(4-methoxy-1H-indole-2-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(5-chlorobenzo[d]isoxazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-5-(4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(1-hydroxy-3,3-dimethylcyclobutane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(4-methyl-2-oxopentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-((R)-2-hydroxybutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1S,3aR,6aS)-2-(5-fluorobenzo[d]isoxazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-5-((S)-2-hydroxy-2-phenylacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((S)-2-hydroxy-2-phenylacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((2R,4R)-5,5,5-trifluoro-2-hydroxy-4-methylpentanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((S)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(4-(tert-butyl)benzoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((R)-2-hydroxy-4,4-dimethylpentanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-5-(2,2-difluoro-2-phenylacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; benzyl ((S)-1-((1R,2S,5S)-6,6-dimethyl-2-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-3-azabicyclo[3.1.0]hexan-3-yl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate; (S)-5-(2,2-difluoro-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(4-fluoro-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(2,2,4-trimethylpentanoyl)-5-azaspiro[2.4]heptane-6-carboxamide; (R)-4-methyl-1-oxo-1-((S)-6-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-5-azaspiro[2.4]heptan-5-yl)pentan-2-ylpropionate; (R)-4-methyl-1-oxo-1-((S)-6-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-5-azaspiro[2.4]heptan-5-yl)pentan-2-yl 2-phenylacetate; (S)-5-(1-hydroxy-4,4-dimethylcyclohexane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-1-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)piperidine-2-carboxamide; (2S,4R)-4-(tert-butyl)-1-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)piperidine-2-carboxamide; (S)-1-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)azepane-2-carboxamide; tert-butyl ((R)-4-methyl-1-oxo-1-((S)-6-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)carbamoyl)-5-azaspiro[2.4]heptan-5-yl)pentan-2-yl)carbamate; (S)-5-(4,4-difluoro-1-methoxycyclohexane-1-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(7-chloro-1H-indole-2-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-acetyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-pivaloyl-5-azaspiro[2.4]heptane-6-carboxamide; (R)—N-((S)-3-(3-fluorophenyl)-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)propan-2-yl)-2-hydroxy-4-methylpentanamide; (S)-5-(2-(methylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(4,4-difluoropentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(4,4-difluorobutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (2S,4R)-1-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-4-(trifluoromethyl)pyrrolidine-2-carboxamide; (S)-5-(2,2-difluorobenzo[d][1,3]dioxole-5-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-propionyl-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-(6-chlorobenzo[d]isoxazole-3-carbonyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (S)-5-(2-(3,3-difluorocyclobutyl)acetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-Isobutyryl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-hexanoyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(3,3-difluoro-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2,2-difluoro-3-methylbutanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-((1R,2R)-2-(trifluoromethyl)cyclopropane-1-carbonyl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((E)-4-methylpent-2-enoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)—N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-(pentanoyl-d9)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-(2-fluoro-2-methylpropanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R)-2,4-dimethylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R)-4-fluoro-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (2S,4R)-1-((S)-2-hydroxy-2-phenylacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-4-(trifluoromethyl)pyrrolidine-2-carboxamide; (S)-5-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopiperidin-3-yl)-4-(perfluorophenoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopiperidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (2S,4S)-1-((R)-2-hydroxy-2-phenylacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-4-phenylpyrrolidine-2-carboxamide; (2S,4S)-1-((S)-2-hydroxy-2-phenylacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-4-phenylpyrrolidine-2-carboxamide; (S)-5-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopiperidin-3-yl)-4-(2,3,6-trifluorophenoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; and 3. The compound of claim 1 or claim 2, or a pharmaceutically acceptable salt thereof, selected from the group consisting of (S)-1-((R)-2-hydroxy-4-methylpentanoyl)-5,5-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pyrrolidine-2-carboxamide.

37. The compound is 4-fluoro-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)amino)pentan-2-yl)-1H-indole-2-carboxamide; N1-(2-fluorophenyl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-cyclohexyl-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-(tert-butyl)-N2-((S)-4,4-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; N1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(2,2,2-trifluoroethyl)oxalamide; (R)—N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)tetrahydrofuran-2-carboxamide; N1-((S)-4,4-dimethyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N2-(3-fluorobicyclo[1.1.1]pentan-1-yl)oxalamide; 5-(2-fluoropropan-2-yl)-N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)isoxazole-3-carboxamide; (1S,3aR,6aS)-2-(2-(tert-butylamino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (1R,2S,5S)-3-((S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (1R,2S,5S)-3-(2-(tert-butylamino)-2-oxoacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-5-(2-((2-fluorophenyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1S,3aR,6aS)-2-(2-((1-methylcyclopropyl)amino)-2-oxoacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; N1-(3-fluorobicyclo[1.1.1]pentan-1-yl)-N2-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)oxalamide; (S)-5-((S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; N-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-4-(trifluoromethyl)-2-oxabicyclo[2.1.1]hexane-1-carboxamide; (S)-5-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (S)-5-((S)-2-hydroxy-2-phenylacetyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; (1R,2S,5S)-3-((S)-2-hydroxy-2-phenylacetyl)-6,6-dimethyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxamide; (S)-5-acetyl-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-5-azaspiro[2.4]heptane-6-carboxamide; and 3. The compound of claim 1 or claim 2, or a pharmaceutically acceptable salt thereof, selected from the group consisting of (2S,4R)-1-((R)-2-hydroxy-4-methylpentanoyl)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)-4-(trifluoromethyl)pyrrolidine-2-carboxamide.

38. A compound of formula (III) or a pharmaceutically acceptable salt thereof: 【Chemical 34】 [In the formula, W is —C(O)—NH— or 【Chemical 35】 and Y is R Ａ -C(R ４ａ ) (R ４ｂ ) -, R Ａ -C(O)-N(R ４ ) -, 【Chemical 36】 , or (R Ｂ ) (R ４ ) N-; However, when W is —C(O)—NH—, Y is R Ａ -C(O)-N(R ４ )-but not; R １ is C １ -C ６ -Alkyl or C ６ -C １０ -aryl, wherein said alkyl and aryl are mono- to perfluorinated; R ２ teeth, 【Chemical 37】 and R ６ is H or C １ -C ６ - alkyl; R ３ａ , R ３ｂ , R ４ａ , R ４ｂ , and R ４ are each independently H or C １ -C ８ - alkyl, or R ３ａ and R ４ , R ３ｂ and R ４ , R ３ａ and R ３ｂ , or R ３ａ and R ４ａ together with the atoms to which they are attached form a monocyclic or bicyclic ring having 3 to 10 ring members selected from C, N, O and S, which, if bicyclic, may be fused, bridged or spiro-fused; R Ａ teeth 【Chemical Formula 38】 and R １１ is H or C １ -C ８ is alkyl; R １２ is H, C １ -C ８ Alkyl, C ６ -C １０ -aryl, -(C １ -C ６ -alkyl)(C ６ -C １０ -aryl); R １１ and R １２ is halo and C １ -C ６ -optionally substituted with 1 to 3 substituents independently selected from the group consisting of haloalkyl; R Ｂ is R １３ or -S(O) ２ -R １３ and R １３ is C ６ -C １０ -aryl, 5-10 membered heteroaryl (1-4 heteroaryl ring members independently selected from N, O and S), R １３ is halo and C １ -C ６ - and optionally substituted with 1 to 3 substituents selected from the group consisting of alkyl.

39. Structure of formula (III-a), (III-b), (III-c), or (III-d): 【Chemical Formula 39】 39. The compound of claim 38, having the formula: or a pharmaceutically acceptable salt thereof.

40. R Ａ is -C(O)NH-(C １ -C ６ -alkyl), -C(O)NH-(C ６ -C １０ -aryl) and -C(O)NH-(C １ -C ６ -alkyl)(C ６ -C １０ -aryl), and R Ａ or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted with 1 to 3 halo.

41. R Ａ is -C(O)NH-(C ６ -C １０ -aryl); R Ａ or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted with 1 to 3 halo.

42. R Ａ is -C(O)NH-(C １ -C ６ -alkyl) and -C(O)NH-(C ６ -C １０ -aryl), wherein C ６ -C １０ - aryl is 1 to 3 C １ -C ６ 40. The compound of claim 39, having the structure of formula (III-c), optionally substituted with -alkyl, or a pharmaceutically acceptable salt thereof:

43. R Ｂ is a 5-10 membered heteroaryl (1-4 heteroaryl ring members independently selected from N, O, and S) or —S(O) ２ -(5-10 membered heteroaryl, where 1-4 heteroaryl ring members are independently selected from N, O, and S), and R Ｂ 1 to 3 C １ -C ６ 40. The compound of claim 39, having the structure of formula (III-d), optionally substituted with -alkyl, or a pharmaceutically acceptable salt thereof:

44. (R)-N4-(2-fluorobenzyl)-2-isobutyl-N1-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)succinimide; (R)-N4-(2,6-difluorobenzyl)-2-isobutyl-N1-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)succinimide; (R)-2-isobutyl-N1-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)-N4-phenylsuccinamide; (5R,6R)-N5-isobutyl-N6-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)spiro[2.4]heptane-5,6-dicarboxamide; N1-(2-fluorophenyl)-N2-((S)-3-methyl-1-(1-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)-1H-1,2,3-triazol-4-yl)butyl)oxalamide; 1-((S)-4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-N-(o-tolyl)-1H-1,2,3-triazole-4-carboxamide; N-(tert-butyl)-1-(4-methyl-1-oxo-1-(((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)amino)pentan-2-yl)-1H-1,2,3-triazole-4-carboxamide; (S)-4-methyl-2-((1-methyl-1H-indole)-5-sulfonamido)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; (S)-4-methyl-2-((2-oxo-1,2-dihydroquinolin-3-yl)amino)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)pentanamide; (S)-4-methyl-2-((1-methyl-1H-indole)-5-sulfonamido)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(2,3,5,6-tetrafluorophenoxy)butan-2-yl)pentanamide; and 2-((4-fluorophenyl)amino)-N-((S)-3-oxo-1-((S)-2-oxopyrrolidin-3-yl)-4-(trifluoromethoxy)butan-2-yl)acetamide 39. The compound of claim 38, selected from the group consisting of: or a pharmaceutically acceptable salt thereof.

45. 40. A pharmaceutical composition comprising a compound of claim 1 or 38, or a pharmaceutically acceptable salt of said compound, and a pharmaceutically acceptable carrier.

46. 46. ​​The pharmaceutical composition of claim 45, comprising a compound of claim 27 or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.

47. The major protease (M) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ｐｒｏ ), a method for inhibiting M ｐｒｏ with a compound of claim 1 or 38 or a pharmaceutically acceptable salt thereof.

48. M ｐｒｏ with a compound of claim 27 or a pharmaceutically acceptable salt of said compound.

49. 40. A pharmaceutical composition for the treatment of COVID-19 in a subject suffering from COVID-19 or for the prevention of COVID-19 in a subject, the pharmaceutical composition comprising a compound of claim 1 or 38 or a pharmaceutically acceptable salt of said compound.

50. 49. The pharmaceutical composition of claim 48, comprising the compound of claim 27 or a pharmaceutically acceptable salt thereof.

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