Cautery System

Abstract

The present invention discloses an ablation system, which includes a radiofrequency generator module for generating a radiofrequency output, a pulse generator module for generating a pulse output, an output control module for selecting between a radiofrequency output and a pulse output mode according to the characteristics of the ablation region, and an ablation consumable for outputting to the ablation region according to the ablation output mode selected by the output control module. The ablation system of the present invention can better realize various application requirements in clinical surgery by combining radiofrequency ablation technology and pulsed electric field ablation technology.

Description

[Technical field]

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS This application claims priority to a Chinese patent application filed on November 3, 2021, bearing application number 202111293952.3, and titled "Ablation System," the entire contents of which are incorporated herein by reference.

[0002] The present invention relates to an ablation system, and more particularly to a novel ablation system that switches or mixes between radiofrequency ablation and pulsed ablation. [Background technology]

[0003] Thermal cauterization, a common technique used in conventional minimally invasive tumor treatment, involves passing high-power radio frequency current through the lesion to move ions in the target tissue, generate heat through friction, and destroy the target tissue through thermal coagulation, with the goal of killing tumor cells.

[0004] The principle of pulsed electric field ablation technology is to induce cell apoptosis by generating irreversible electroporation in the cell membrane and thus the cell nucleus. The energy of the pulsed electric field is applied to tumor cells, causing irreversible electroporation in the tumor cells, thereby achieving the purpose of treatment.

[0005] Radiofrequency ablation technology, especially when used in conjunction with an irrigation pump, has a wide ablation range and can treat cells in a wider cancerous area; however, radiofrequency ablation technology is not selective and ablates indiscriminately, which may damage blood vessels, nerves, and other locations.

[0006] Pulsed electric field ablation technology is non-thermal ablation, so it can effectively protect adjacent tissues. However, the action range of pulsed electric field ablation technology is limited, and in order to prevent the energy of the pulsed electric field from adversely affecting the heart, it is necessary to add cardiac synchronization to the pulsed electric field ablation technology at a position close to the heart so that it discharges during the refractory period. In addition, the output of the pulsed electric field is usually a rectangular pulse wave, which contains a rich frequency component, so it is easy to stimulate peripheral motor nerves.

[0007] In view of the shortcomings of radiofrequency ablation technology and pulsed electric field technology in clinical applications, the pulsed electric field ablation devices and radiofrequency ablation devices in the existing market are not integrated, which makes it very inconvenient for doctors to use both treatment methods simultaneously.

[0008] Therefore, the present invention puts forward a new ablation system implementation means by combining radiofrequency ablation technology and pulsed electric field ablation technology to better realize various application requirements in clinical surgery. Summary of the Invention

[0009] The present invention provides a new ablation system that switches or mixes between radiofrequency ablation and pulsed ablation, which combines radiofrequency ablation technology and pulsed electric field ablation technology, and selects between radiofrequency output and pulsed output ablation output modes according to the characteristics of the ablation area, thereby better realizing various application requirements in clinical surgery.

[0010] According to an embodiment of the present invention, there is provided an ablation system comprising at least a radiofrequency generator module for generating a radiofrequency output, a pulse generator module for generating a pulsed output, an output control module for selecting between the radiofrequency output and the pulsed output modality in response to a characteristic of the ablation region, and an ablation consumable for providing an output to the ablation region in response to the ablation output modality selected by the output control module.

[0011] Preferably, in the cauterization system of the present invention, the output control module selects an ablation mode from among radio frequency output only, pulse output only, and mixed pulse and radio frequency output.

[0012] Preferably, in the cauterization system of the present invention, the output control module allows an operator to manually select the cauterization output mode.

[0013] Preferably, in the cauterization system of the present invention, the output control module automatically selects the cauterization output mode.

[0014] Preferably, in the ablation system of the present invention, the characteristic of the ablation region is a characteristic that is estimated in advance for the ablation region.

[0015] Preferably, in the ablation system of the present invention, the characteristic of the ablation region is a size of the ablation region.

[0016] Preferably, in the ablation system of the present invention, the size of the ablation region is determined by parameters of pulse ablation, which preferably include at least one of a pulse amplitude, a pulse width, a number of pulse groups, and a number of pulses.

[0017] Preferably, in the ablation system of the present invention, the size of the ablation region is determined by parameters of radiofrequency ablation, which preferably include at least one of power, temperature, time, and irrigation rate.

[0018] Preferably, in the ablation system of the present invention, the characteristic of the ablation region is a location of the ablation region.

[0019] Preferably, in the ablation system of the present invention, the ablation consumable is provided with a corresponding position sensor, and the ablation system further comprises a position signal collection module for collecting position information of the ablation consumable by a position sensor of the ablation consumable, and a navigation system for determining a position of an ablation region by the position information of the ablation consumable collected by the position signal collection module.

[0020] Preferably, in the ablation system of the present invention, the characteristic of the ablation region is an electrical impedance of the ablation region.

[0021] Preferably, in the ablation system of the present invention, the ablation system further comprises an impedance measurement module for measuring the electrical impedance of the ablation region.

[0022] Preferably, the electrical impedance is a complex impedance.

[0023] Preferably, in the ablation system of the present invention, the characteristic of the ablation region is the pH of the ablation region.

[0024] Preferably, in the ablation system of the present invention, the characteristic of the ablation region is a change in a parameter of the ablation region before and after a provisional ablation test.

[0025] Preferably, in the ablation system of the present invention, the output control module can select an ablation output method based on at least two of the following characteristics of the ablation region: size of the ablation region, position of the ablation region, electrical impedance of the ablation region, pH of the ablation region, and parameter changes before and after a preliminary ablation test of the ablation region.

[0026] The output control module is the core of the system, which can select the output energy mode, as well as the output channel, electrical parameter setting, and perfusion selection. Here, the focus is on the selection of the output mode, and the application of only pulse output, only radio frequency output, and pulse and radio frequency mixed output can all be realized. Specifically, the pulse and radio frequency mixed output can be the pulse and radio frequency alternate output mode.

[0027] Different output modes can achieve different cauterization effects. This allows the operator to select a more appropriate output mode specifically for the cauterization area, such as differences in the characteristics of the cauterization area, to perform the cauterization procedure. For example, the characteristics of the cauterization area used to characterize the differences in the cauterization area may include the size of the cauterization area, the position of the cauterization area, the electrical impedance of the cauterization area, the pH of the cauterization area, and parameter changes before and after a preliminary cauterization test of the cauterization area. The operator may select the cauterization output mode in real time from pulse output only, radiofrequency output only, and mixed pulse and radiofrequency output according to at least one characteristic of the cauterization area.

[0028] When the mixed output mode is selected, it not only avoids indiscriminate damage to the surrounding tissues, but also lowers the threshold of cells in the ablation area to a certain extent. When only the radiofrequency output ablation mode is selected, it can prevent the effects on the heart and expand the ablation range. Meanwhile, when only the pulsed electric field ablation mode is selected, its selective characteristics can better protect the surrounding tissues during the ablation of cancer cells. [Brief description of the drawings]

[0029] The present invention will be more fully understood from the drawings and the following detailed description, in which like elements are numbered in like manner, and in which: [Figure 1] FIG. 1 is a schematic block diagram of an ablation system according to an embodiment of the present invention. [Diagram 2] FIG. 2 is a schematic topology diagram of a pulse generator circuit. [Diagram 3]FIG. 1 is a schematic topology diagram of a pulse generator circuit capable of realizing a sinusoidal pulse. [Figure 4] FIG. 1 shows five pulse output waveforms. [Diagram 5] FIG. 13 shows an output waveform that realizes a sinusoidal pulse. [Figure 6] FIG. 4 is a diagram showing each parameter of a pulse output waveform. [Figure 7] FIG. 1 is a schematic topology diagram of a radio frequency generator circuit. [Figure 8] FIG. 1 is a schematic diagram of channel setting by a power control module of an ablation system according to an embodiment of the present invention. [Figure 9] FIG. 1 is a schematic diagram showing pulsed and alternating radio frequency output. [Figure 10A] 10A-C are schematic diagrams of ablation of three different tissues. [Figure 10B] 10A-C are schematic diagrams of ablation of three different tissues. [Figure 10C] 10A-C are schematic diagrams of ablation of three different tissues. EMBODIMENTS OF THE PRESENTINVENTION

[0030] The present invention will be described in more detail below with reference to the drawings and embodiments, but the present invention is not limited to the contents of the embodiments.

[0031] FIG. 1 is a schematic block diagram of an embodiment of an ablation system according to the present invention.

[0032] As shown in FIG. 1 , the main structural modules of the ablation system 100 according to the embodiment of the present invention include a pulse generator module 101, a radio frequency generator module 102, an output control module 103, and an ablation consumable 104. It is easily conceivable to those skilled in the art that the ablation system 100 includes not only the main structural modules listed above, but also many other structural modules, which will be described in detail below. Since the technical solution of the present invention focuses on the selection of the ablation energy output mode, the above-mentioned several modules are referred to as main structural modules herein. However, it is easily conceivable to those skilled in the art that in an actually used ablation system, the main structural modules mentioned herein and the other structural modules described below may be modules constituting the ablation system, each playing an important role, and the combination of them realizes ablation.

[0033] The pulse generator module 101 is configured to generate a pulse output. Specifically, the pulsed electric field ablation technique uses the pulse output generated by the pulse generator module 101 to cause irreversible electroporation in the cell membrane and thus the cell nucleus, thereby inducing cell apoptosis. For example, in tumor ablation, the pulsed electric field energy generated by the pulse generator module 101 is applied to tumor cells to cause irreversible electroporation in the tumor cells, thereby achieving the purpose of treatment.

[0034] Figure 2 is a schematic diagram of a pulse generator circuit topology as a preferred embodiment of the pulse generator module 101. The pulse circuit topology shown in Figure 2 can realize any waveform and combinations thereof as shown in Figures 4A-4E below.

[0035] Figure 3 is a schematic diagram of the topology of a pulse generator circuit that can realize a sine wave pulse. As shown in Figure 3, a band pass filter is introduced into the topology of the pulse generator circuit to realize the output of a sine wave pulse signal. The sine wave pulse signal can effectively solve the electromagnetic interference caused by the pulse electric field signal due to its rich frequency components, and at the same time, can reduce the irritating effect when the pulse electric field acts.

[0036] 4A-4E are diagrams showing five pulse output waveforms. Fig. 5 is a diagram showing an output waveform that realizes a sine wave pulse. Those skilled in the art can easily imagine that the pulse waveforms that can actually be output are not limited to the waveforms shown in the figures, and can be arbitrarily combined.

[0037] FIG. 6 is a diagram showing the parameters of the pulse output waveform. As shown in FIG. 6, the pulse schematic diagram shows some commonly used pulse output parameters. For example, here, the commonly used parameters for the pulse electric field are as follows:

[0038] Pulse amplitude V: ±300 - ±10kV; Pulse width W: 100ns - 100us; Pulse interval I: 0 - 1ms; Pulse group duration T1: less than 200 ms; Pulse group interval T2: 10ms - 3s; Number of pulse groups N: 1 - 120 groups.

[0039] The radiofrequency generator module 102 is configured to generate radiofrequency power. Specifically, high-power radiofrequency current is applied to the lesion site to move ions in the target tissue, generate heat through friction, and destroy the target tissue through thermal coagulation. This process achieves the purpose of killing tumor cells.

[0040] FIG. 7 is a schematic diagram of the topology of a radio frequency generator circuit.

[0041] As shown in Figure 7, to adjust the radio frequency output energy, the power amplifier power supply control circuit is controlled to control the energy output by the power amplifier power supply. The functional power supply and the radio frequency power amplifier drive control circuit act together on the radio frequency power amplifier circuit, and after the output signal is processed by the isolation transformer, the radio frequency output is obtained. The commonly used output parameters are the maximum power of 300W and the output frequency of 30kHz - 2MHz.

[0042] The output control module 103 is configured to select between radiofrequency output and pulsed output modes according to the characteristics of the ablation region. Specifically, the output control module can select the ablation output mode as radiofrequency output only, pulsed output only, or mixed pulsed and radiofrequency output.

[0043] The output control module 103 is the core component module of the ablation system 100 according to the present invention. In addition to selecting the output mode to realize the application of only pulse output, only radiofrequency output, and mixed pulse and radiofrequency output, the output control module 103 can also realize the selection of output channel, setting of electrical parameters, and selection of perfusion. FIG. 8 is a schematic diagram of channel setting by the output control module of the ablation system according to an embodiment of the present invention. As shown in FIG. 8, in one embodiment of the present invention, the output control module 103 first performs the selection of output channel and setting of electrical parameters, and then determines whether to perfuse. After the above setting, selection, and determination, the output control module 103 can choose the output mode of only pulse output, only radiofrequency output, or mixed pulse and radiofrequency output.

[0044] Specifically, the pulse and radio frequency mixed output can be a pulse and radio frequency alternating output mode. Figure 9 is a schematic diagram showing a pulse and radio frequency alternating output.

[0045] An ablation consumable 104, such as an ablation electrode, is configured to provide output to the ablation region according to an ablation output strategy selected by the output control module 103.

[0046] As mentioned above, the ablation system 100 may include not only the major structural modules listed above, but also other structural modules, which may include a pulse generator module, a radiofrequency generator module, a perfusion module, an impedance measurement module, an electrical signal acquisition module, a self-check module, a temperature measurement module, a sensing synchronization module, a human-machine interaction module, a position signal acquisition module, etc. (not shown in FIG. 1 ).

[0047] To prevent the energy of the pulsed electric field from adversely affecting the heart, the sensing and synchronization module may receive an electrocardiogram synchronization signal to discharge during a refractory period when utilizing pulsed electric field ablation techniques.

[0048] The importance measurement module can display the output impedance status in real time, so as to check whether the inserted consumables are in the correct position, and immediately stop output when impedance abnormality is detected to ensure safety. The following will explain in more detail.

[0049] The electrical signal collection module can collect signals such as voltage, current, and power energy of the pulsed electric field output energy in real time, and can also collect signals such as voltage, current, and power energy during radio wave output in real time, thereby ensuring the safety and effectiveness of the two energy outputs.

[0050] To ensure the safety of the system, the self-check module checks the pulsed electric field output circuit and the radio frequency wave output circuit before each output, and outputs only if they pass the self-check.

[0051] The temperature measurement module measures the temperature status of the power path in real time. It can not only ensure temperature measurement and control during radio frequency power output, but also monitor at the pulse power stage to prevent overheating caused by the pulse electric field output time being too long. The temperature measurement module also provides another path for measuring the temperature of different components to prevent overheating caused by the influence of radio frequency power on other components.

[0052] The location signal collection module primarily collects and outputs magnetic signals of the ablation consumables 104 to facilitate processing of location information by a possible navigation system.

[0053] The human-machine interaction module is for realizing the human-machine interaction function.

[0054] The perfusion module has two main functions: first, to cool the output channel by perfusion to achieve better ablation depth, especially when applied in radiofrequency output mode, and to eliminate the temperature rise problem during long pulse ablation when the ablation area is too large and long pulse ablation time is required in pulse output mode; second, to realize the injection of conductive liquid by perfusion, to prevent the output path from overhanging or the impedance from being too high, so that the pulse electric field energy and radiofrequency reach a certain load output state.

[0055] Now, let us return to the topic of output mode control.

[0056] As discussed above, the output control module 103 is configured to select between radiofrequency and pulsed output modes depending on the characteristics of the ablation region.

[0057] In this application, the term "selection" may refer to a surgeon manually selecting an ablation output type, and the manual selection is received by the output control module 103 to implement related control. The output control module 103 may also automatically select an ablation output type using methods such as artificial intelligence.

[0058] As used herein, the term "ablation region" refers to a region to be ablated, which may be tissue in a living body, such as a tumor. In certain embodiments, the terms "ablation region" and "ablation target" are used interchangeably and have the same meaning. As used herein, the term "characteristic" may refer to a property, attribute, property, characteristic, or other physical, mathematical, or chemical variable or parameter for characterizing the ablation region or ablation target. In certain embodiments, the term "characteristic" is used interchangeably and has the same meaning with terms such as property, attribute, property, characteristic, variable, parameter, coordinate, etc.

[0059] For example, the characteristics of the ablation region mentioned in the embodiments enumerated herein may include the size of the ablation region, the position of the ablation region, the electrical impedance of the ablation region, the pH of the ablation region, parameter changes before and after the preliminary ablation test of the ablation region, etc. The output control module 103 may select the optimal ablation output mode according to one of the above characteristics or any combination of the above characteristics.

[0060] The characteristics of the ablation region may be characteristics that are pre-estimated for the ablation region. For example, the size of the ablation region and the position of the ablation region may be characteristics that are pre-estimated for the ablation region based on existing parameters or settings.

[0061] The following specifically describes how to select an appropriate output mode according to the characteristics of the cauterization region.

[0062] In certain embodiments, the characteristic of the ablation region is the size of the ablation region.

[0063] In the pulse ablation mode, for example, the size of the ablation area may be determined by the parameters of the pulse ablation. The parameters of the pulse ablation include at least one of the pulse amplitude, the pulse width, the number of pulse groups, and the number of pulses. In the present application, the ablation range is used in combination with an attached consumable. When the attached consumable has three electrodes, the parameter information of the electrodes may be determined by reading the information of the attached consumable. In this case, the pulse ablation range is considered to be a spherical area formed by the three electrodes. The size of the spherical ablation area is related to the pulse amplitude, the pulse width, the number of pulse groups, and the number of pulses set above. Among them, the pulse amplitude plays a decisive role in directly determining the magnitude of the electric field intensity, while the pulse width, the number of pulse groups, and the number of pulses determine the action time and play a role of coefficient expansion or reduction of the size of the ablation area. The size of the ablation area may be estimated by a mathematical model established based on these parameters.

[0064] In the radiofrequency ablation mode, for example, the size of the ablation region can be determined by parameters of radiofrequency ablation. The parameters of radiofrequency ablation include at least one of power, temperature, time, and irrigation rate. Specifically, the range of the ablation region can be determined by a combination of power, temperature, and time, and when irrigation is used in combination, the size of the ablation region can also be evaluated using the irrigation rate as a parameter. The size of the ablation region can be estimated by a mathematical model established based on these parameters.

[0065] In certain embodiments, the property of the ablation region is the location of the ablation region.

[0066] The ablation consumables may be equipped with corresponding position sensors. The ablation system may obtain the position information of the related consumables through the position sensors and transmit the information to the associated navigation system to determine the ablation position. Specifically, as described above, the ablation system 100 may further include a position signal collection module and a navigation system. The position signal collection module is used to collect the position information of the ablation consumables through the position sensors of the ablation consumables. The navigation system is used to determine the position of the ablation region according to the position information of the ablation consumables collected by the position signal collection module. When multiple consumables are used in combination, the navigation system may estimate the location range of the tumor according to the position information. When the navigation system transmits this information to the output control module of the ablation system, the output control module can intelligently determine whether the selected ablation mode can meet the requirements of the ablation region and appropriately select the optimal output mode so that the electrodes are output in the appropriate ablation energy mode.

[0067] In the above two embodiments, the characteristics of the ablation region are the size and the position of the region, respectively. However, the ablation range evaluation (i.e., size) of the pulse and radio frequency waves and the ablation region (i.e., position) determined by the position information can be combined to assist the surgeon in switching channels in the intelligent mode, and pulse output only, radio frequency output only, or radio frequency and pulse alternate output can be realized. At the same time, intelligent switching of perfusion can be realized. This is because the amount of perfusion is related to the size of the ablation region. This can meet the requirements of the ablation region required by the surgeon. In addition, the surgeon can manually select the output mode, but by informing the surgeon of the ablation region, the surgeon's accuracy of ablation can be greatly improved.

[0068] In certain embodiments, the property of the ablation region is the electrical impedance of the ablation region.

[0069] As mentioned above, the ablation system 100 according to the present invention may include an impedance measurement module for measuring the electrical impedance of the ablation region.

[0070] In a particular preferred embodiment, the impedance measuring module is capable of measuring complex impedance. The complex impedance of a living body is the electrical impedance characteristic of a living organ, tissue or cell excited with a safe current or voltage, reflecting the dielectric and conductive properties of the tissue. The dielectric property refers to the response of the positive and negative combined charges of the dielectric of the living cell to an external electric field, and the conductive property refers to the response of the conductive free charges (ions, electrons) in the living cell to an external electric field.

[0071] The measurement of complex impedance can indirectly reflect the cell changes during ablation. By applying a sinusoidal signal covering 5kHz - 200MHz to each electrode, and then re-collecting and converting the applied signal, the amplitude spectrum and phase spectrum reflecting each complex impedance characteristic at various frequencies in the frequency domain can be obtained. These amplitude and phase spectra can grasp the change status of the whole tissue parameters and even ions. Whether pulse ablation or radiofrequency ablation, after ablation, the corresponding ions such as Na, K and proteins can be changed, and the complex impedance can be intuitively reflected. When these parameters change to a certain extent, the magnitude and speed of the change can indirectly reflect the effect of ablation. This allows the surgeon to grasp the ablation situation and judge whether the ablation method meets expectations. It also helps the surgeon dynamically switch the ablation method in an intelligent manner to achieve the ablation effect.

[0072] Although the preferred embodiment teaches measuring complex impedance, it will be readily appreciated by those skilled in the art that by measuring pure impedance, effects can be determined simply by determining the magnitude of impedance in the time domain, although it should be noted, of course, that determining effects using pure impedance does not provide as much data as would be obtained using complex impedance.

[0073] In certain embodiments, the property of the ablation region is the pH of the ablation region.

[0074] That is, the cauterization system 100 according to the present invention may also include a module for measuring the pH of the cauterization area. For example, by measuring the change in pH of the cauterization area, the cauterization effect may be indirectly determined while indirectly grasping the change in ions. Conversely, a more appropriate cauterization output mode may be selected based on the change in pH.

[0075] In certain embodiments, the characteristic of the ablation region is a parameter change of the ablation region before and after a preliminary ablation test.

[0076] Figures 10A-10C are schematic diagrams of three different tissue ablation modes. The following describes the selection and action of different modes of ablation for Figures 10A-10C.

[0077] FIG. 10A is a schematic diagram of tissue ablation in a first example.

[0078] The tissue 1 between the ablation points 1001 and 1002 is ablated. In this case, the tumor cells at the ablation points 1001 and 1002 have a large difference, which can be reflected in the characteristics of the ablation area, such as electrical impedance, pH, and parameter changes before and after the preliminary ablation test. In this case, a pulse and radiofrequency mixed ablation method can be adopted according to the characteristics of the ablation area. By controlling the radiofrequency ablation to a constant temperature, not only can the surrounding tissue not be indiscriminately damaged, but the threshold of the cells in the ablation area can be lowered to a certain extent, and the pulse ablation method can better induce irreversible electroporation in the tumor cells in the ablation area.

[0079] FIG. 10B is a schematic diagram of tissue ablation in the second example.

[0080] The tissue 2 between the ablation points 1003 and 1004 is ablated. In this case, the tissue 2 between the ablation points 1003 and 1004 is close to the heart and has a large tumor area, which may be reflected in the characteristics of the ablation region, such as the size and location of the ablation region. In this case, a radiofrequency-only ablation method may be selected to prevent influence on the heart and to expand the ablation range, depending on the characteristics of the ablation region.

[0081] FIG. 10C is a schematic diagram of tissue ablation in a third example.

[0082] The tissue 3 between the ablation points 1005 and 1006 is ablated. In this case, there are abundant blood vessels, nerves, or bile ducts in the tissue 3 between the ablation points 1005 and 1006, which can be reflected in the characteristics of the ablation area, such as the size, position, electrical impedance, pH, and parameter changes before and after the preliminary ablation test. In this case, due to the characteristics of the ablation area, radiofrequency ablation is not appropriate, and it is more appropriate to select only pulsed electric field ablation, which can better protect the surrounding tissue while ablating the cancer cells due to its selective characteristics.

[0083] Although only three exemplary cases are shown in the present application, those skilled in the art can easily imagine that there are various conditions for the ablation region (ablation target). In any case, according to the teachings of the present invention, it is necessary to determine an appropriate ablation energy output based on the characteristics of the ablation region, such as the size, position, electrical impedance, pH, and parameter changes before and after the provisional ablation test.

[0084] The embodiments of the present invention are not limited to the above-described embodiments, and those skilled in the art may make various changes and modifications to the form and details of the present invention without departing from the spirit and scope of the present invention, all of which are deemed to be within the protection scope of the present invention.

Claims

1. a radio frequency generator module for generating a radio frequency output; a pulse generator module for generating a pulsed output; an output control module for selecting between radiofrequency output and pulse output modes according to the characteristics of the ablation region; an ablation consumable for applying an output to the ablation region in accordance with the ablation output method selected by the output control module.

2. The output control module Radio wave output only, Pulse output only, The ablation system of claim 1 , configured to select between pulsed and radio frequency mixed output.

3. The ablation system of claim 1 , wherein the output control module is configured to allow an operator to manually select an ablation output mode.

4. The ablation system of claim 1 , wherein the output control module is configured to automatically select an ablation output mode.

5. The ablation system according to claim 1 , wherein the characteristics of the ablation region are pre-estimated characteristics of the ablation region.

6. The characteristics of the ablation region are: the size of the ablation area, the location of the ablation area, the electrical impedance of the ablation area, the pH of the ablated area, and The ablation system according to claim 1 , wherein the change is one of parameters before and after a preliminary ablation test of the ablation region.

7. The ablation system of claim 6 , wherein the size of the ablation region is determined by pulse ablation parameters.

8. The ablation system of claim 7 , wherein the pulse ablation parameters include at least one of pulse amplitude, pulse width, number of pulse groups, and number of pulses.

9. The ablation system of claim 6 , wherein the size of the ablation region is determined by radiofrequency ablation parameters.

10. The ablation system of claim 9, wherein the radiofrequency ablation parameters include at least one of power, temperature, time, and irrigation rate.

11. the ablation consumable includes a corresponding position sensor; The ablation system further comprises: a position signal collecting module for collecting position information of the ablation consumable by a position sensor of the ablation consumable; The ablation system of claim 6 , further comprising: a navigation system for determining a location of an ablation region using location information of the ablation consumable collected by the location signal collection module.

12. The ablation system of claim 6 , further comprising an impedance measurement module for measuring the electrical impedance of the ablation region.

13. The ablation system of claim 12 , wherein the electrical impedance is a complex impedance.

14. The ablation system of claim 1 , wherein the output control module is further configured to select an ablation output mode according to at least two of the following characteristics of the ablation region: the size of the ablation area, the location of the ablation area, the electrical impedance of the ablation area, the pH of the ablated area, and Changes in parameters before and after the preliminary ablation test of the ablation area.

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