Oil-in-water emulsion composition

Abstract

To provide an oil-in-water emulsion composition in which an oil phase including ceramides are stably emulsified and dispersed as fine particles, and which is excellent in storage stability, and ensures smoothness and superior moisturization on the skin after application of the composition.SOLUTION: An oil-in-water emulsion composition is provided, containing the following components (A), (B), (C), and (D): (A) ceramides, (B) an oil agent which is in a liquid state at 25°C, (C) a nonionic surfactant which has an HLB of less than 10, and (D) water, wherein the emulsion particles have a Z-average particle diameter of 0.05 μm to 0.3 μm.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to an oil-in-water emulsion composition and a method for producing the same. [Background technology]

[0002] The gaps between the keratinocytes that make up the stratum corneum, the outermost layer of the skin, contain lipids called intercellular lipids. Ceramides, which make up about 50% of the intercellular lipids, are deeply involved in rough and dry skin, and it is known that topical ceramide supplementation can improve the condition of the stratum corneum. However, when solid fats such as ceramides are incorporated into cosmetics, it is difficult to stabilize them in the formulation because the solid fats are highly crystalline and have high melting points. Therefore, techniques for stably incorporating these solid fats are being investigated. For example, Patent Document 1 describes that a translucent cosmetic preparation that contains ceramide, an oily component, a nonionic surfactant, and water, and in which the O / W emulsion that these components constitute has an average particle size of 100 nm to 300 nm, has excellent stability over time and a beautiful appearance. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] International Publication No. 2004 / 045566 Summary of the Invention [Problem to be solved by the invention]

[0004] However, conventional cosmetic preparations have not been able to provide sufficient smoothness or moisturizing feeling to the skin after application, and also have problems with storage stability. [Means for solving the problem]

[0005] The present inventors have found that by using a combination of ceramides, a liquid oil, and a specific nonionic surfactant, it is possible to stably emulsify and disperse an oil phase containing ceramides into fine particles, thereby obtaining an oil-in-water emulsion composition that has excellent storage stability, leaves the skin smooth after application, and provides an excellent moist feeling.

[0006] The present invention comprises the following components (A), (B), (C) and (D): (A) Ceramides, (B) An oil that is liquid at 25°C. (C) a nonionic surfactant having an HLB value of less than 10; (D)Water The present invention relates to an oil-in-water emulsion composition comprising the above compound and having a Z-average particle size of 0.05 to 0.3 μm. The present invention also relates to a method for producing the oil-in-water emulsion composition, comprising step 1 of obtaining an oil phase containing component (A), component (B), and component (C), and step 2 of mixing the oil phase obtained in step 1 with an aqueous phase containing component (D). Effect of the Invention

[0007] The oil-in-water emulsion composition of the present invention has an oil phase containing ceramides stably emulsified and dispersed as fine particles, has excellent storage stability, and leaves the skin smooth and moisturized after application. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0008] Examples of the ceramides of component (A) used in the present invention include natural ceramides such as ceramides 1, 2, 3, 4, 5, 6, and 7, sphingosine derivatives such as phytosphingosine, and ceramide-like structural substances described in JP-A-62-228048, JP-A-63-216812, JP-A-63-227513, JP-A-64-29347, JP-A-64-31752, and JP-A-8-319263. Specific examples of the ceramide-like structural substances include compounds represented by the following general formulas (1) and (2) from the viewpoint of forming oils containing ceramides into fine particles and improving storage stability.

[0009] [ka]

[0010] [In the formula, R 1b is a hydrocarbon group having 10 to 26 carbon atoms, R 2b represents a hydrocarbon group having 9 to 25 carbon atoms, and X is -(CH2) n - (where n is an integer from 2 to 6).

[0011] [ka]

[0012] (In the formula, R 1 and R 2 are the same or different and each represents a hydrocarbon group having 1 to 40 carbon atoms which may be hydroxylated, and R 3 represents an alkylene group having 1 to 6 carbon atoms or a single bond; R 4 represents a hydrogen atom, an alkoxy group having 1 to 12 carbon atoms, or a 2,3-dihydroxypropyloxy group, provided that R 3 When is a single bond, R 4 is a hydrogen atom.)

[0013] In the general formulas (1) and (2), the hydrocarbon group is preferably an alkyl group or an alkenyl group. An example of a compound of general formula (1) is N-(hexadecyloxyhydroxypropyl)-N-hydroxyethylhexadecanamide, and an example of a compound of general formula (2) is long-chain dibasic acid bis-3-methoxypropylamide. The compound represented by the general formula (1) is a pseudo-ceramide, a ceramide functional component, which can supplement the function of ceramide and improve skin conditions (such as moisture content).

[0014] From the viewpoint of forming oils containing ceramides into fine particles and improving storage stability, component (A) preferably contains one or more types selected from natural ceramides, sphingosines, and the compounds represented by the general formulas (1) and (2), more preferably contains one or more types selected from natural ceramides, sphingosines, and the compounds represented by the general formula (1), even more preferably contains one or more types selected from natural ceramides, phytosphingosine, and N-(hexadecyloxyhydroxypropyl)-N-hydroxyethylhexadecanamide, and even more preferably contains N-(hexadecyloxyhydroxypropyl)-N-hydroxyethylhexadecanamide.

[0015] One or more types of component (A) can be used, and from the viewpoint of forming the ceramide-containing oil into fine particles, improving storage stability, and improving the moist feeling of the skin after application, the content is preferably 0.3 mass% or more of the total composition, more preferably 0.5 mass% or more, even more preferably 0.6 mass% or more, even more preferably 0.7 mass% or more, especially preferably 0.8 mass% or more, preferably 4 mass% or less, more preferably 3 mass% or less, even more preferably 2 mass% or less, even more preferably 1.8 mass% or less, and especially preferably 1.3 mass% or less. The content of component (A) in the total composition is preferably 0.3 to 4 mass%, more preferably 0.5 to 3 mass%, even more preferably 0.6 to 2 mass%, even more preferably 0.7 to 1.8 mass%, and especially preferably 0.8 to 1.3 mass%. The content of component (A) in the entire composition is preferably from 0.3 to 2 mass %, more preferably from 0.3 to 1.8 mass %, and even more preferably from 0.5 to 1.5 mass %.

[0016] Component (B) is an oil that is liquid at 25° C. Liquid means that it has fluidity, and includes a paste state. Examples of the oil agent of component (B) include hydrocarbon oils, ester oils, ether oils, higher alcohols, silicone oils, and higher fatty acids.

[0017] More specifically, examples of the hydrocarbon oil include squalane, liquid paraffin, liquid isoparaffin, light liquid isoparaffin, and heavy liquid isoparaffin. From the viewpoint of making the oil containing ceramides into fine particles, improving storage stability, improving the smoothness of the skin after application, and improving the moist feeling of the skin after application, the hydrocarbon oil preferably contains one or more selected from squalane, liquid paraffin, liquid isoparaffin, and light liquid isoparaffin, more preferably contains one or more selected from squalane, liquid paraffin, and liquid isoparaffin, even more preferably contains one or more selected from squalane and liquid isoparaffin, and even more preferably contains liquid isoparaffin.Note that liquid isoparaffin is also called hydrogenated polyisobutene.

[0018] Ester oils include monoester oils, diester oils, triester oils and tetraester oils. Examples of monoester oils include monoesters of aliphatic or aromatic monocarboxylic or dicarboxylic acids having 2 to 24 carbon atoms. Specific examples include cetyl 2-ethylhexanoate, cetyl octanoate, isononyl isononanoate, isotridecyl isononanoate, isostearyl isostearate, hexyl laurate, isopropyl myristate, octyldodecyl myristate, myristyl myristate, 2-hexyldecyl myristate, palmitic acid, and the like. isopropyl palmitate, octyl palmitate, 2-hexyldecyl palmitate, butyl stearate, isocetyl stearate, isocetyl isostearate, decyl oleate, isodecyl benzoate, octyl methoxycinnamate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate, lanolin acetate, 2-ethylhexyl succinate, 2-hexyldecyl adipate, alkyl benzoate (C12 to C15), and jojoba oil. From the viewpoints of forming oils containing ceramides into fine particles, improving storage stability, improving the smoothness of the skin after application, and improving the moist feeling of the skin after application, the monoester oil preferably contains one or more selected from isononyl isononanoate, isotridecyl isononanoate, isostearyl isostearate, octyldodecyl myristate, and jojoba oil, more preferably contains one or more selected from isononyl isononanoate, isotridecyl isononanoate, isostearyl isostearate, and jojoba oil, and even more preferably contains isononyl isononanoate.

[0019] Examples of diester oils include diesters of dicarboxylic acids having 3 to 18 carbon atoms and difatty acid esters of polyhydric alcohols. Specific examples include propylene glycol dicaprylate, neopentyl glycol dicaprate, glycol distearate, propylene glycol diisostearate, glyceryl monomyristate monoisostearate, glycerin di-2-heptylundecanoate, di-2-ethylhexyl succinate, diisopropyl sebacate, diisostearyl malate, ethylene glycol di-2-ethylhexanoate, diisobutyl adipate, di-2-heptylundecyl adipate, and di-2-ethylhexyl sebacate. The diester oil preferably contains one or more selected from propylene glycol dicaprylate and neopentyl glycol dicaprate, and more preferably contains neopentyl glycol dicaprate, from the viewpoints of forming oils containing ceramides into fine particles, improving storage stability, improving the smoothness of the skin after application, and improving the moist feeling of the skin after application.

[0020] Triester oils include tri-fatty acid esters of trivalent or higher polyhydric alcohols, and specific examples thereof include glyceryl trimyristate, glyceryl triisopalmitate, glyceryl tri-2-heptylundecanoate, trimethylolpropane triethylhexanoate, trimethylolpropane trioctanoate, tri(caprylic / capric)glyceryl, trioleate, glyceryl tri-2-ethylhexanoate, and glyceryl triisostearate, as well as vegetable oils such as olive oil, macadamia nut oil, meadowfoam oil, castor oil, safflower oil, sunflower oil, avocado oil, canola oil, apricot kernel oil, rice germ oil, and rice bran oil. From the viewpoints of forming fine particles of oils containing ceramides, improving storage stability, improving the smoothness of the skin after application, and improving the moist feeling of the skin after application, the triester oil preferably contains one or more selected from caprylic / capric triglyceride, glyceryl tri-2-ethylhexanoate, and vegetable oils, more preferably contains one or more selected from caprylic / capric triglyceride and olive oil, and even more preferably contains caprylic / capric triglyceride.

[0021] Examples of tetraester oils include tetra fatty acid esters of polyhydric alcohols having 4 or more valences, and specific examples thereof include pentaerythritol tetra(behenic acid / benzoic acid / ethylhexanoic acid), pentaerythritol tetraethylhexanoate, pentaerythritol tetraoctanoate, and pentaerythritol tetra-2-ethylhexanoate.

[0022] The ester oil preferably contains one or more selected from monoester oil, diester oil and triester oil, more preferably contains one or more selected from monoester oil and diester oil, and even more preferably contains a diester oil, from the viewpoints of forming ceramide-containing oil into fine particles, improving storage stability, improving skin smoothness after application and improving moist feeling of skin after application. In addition, the ester oil may be either one that contains a hydroxyl group in its structure or one that does not contain a hydroxyl group. From the viewpoint of forming the ceramide-containing oil into fine particles and improving storage stability, however, it is preferable to use an ester oil that does not contain a hydroxyl group in its structure.

[0023] The ether oil includes dialkyl ethers, specifically, dihexyl ether, dicaprylyl ether, cetyl-1,3-dimethylbutyl ether, etc., and preferably includes cetyl-1,3-dimethylbutyl ether.

[0024] Examples of higher alcohols include those having a straight or branched alkyl or alkenyl group having 10 to 24 carbon atoms, such as lauryl alcohol, myristyl alcohol, isocetyl alcohol, isostearyl alcohol, 2-octyldodecanol, and oleyl alcohol.

[0025] Examples of silicone oils include volatile and non-volatile linear dimethylpolysiloxanes such as dimethylpolysiloxane (1cs), dimethylpolysiloxane (1.5cs), dimethylpolysiloxane (2cs), and dimethylpolysiloxane (6cs); branched siloxanes such as methyltrimethicone, tris(trimethylsilyl)methylsilane, and tetrakis(trimethylsilyl)silane; cyclic dimethylsiloxanes such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, and dodecamethylcyclohexasiloxane; and methylphenylpolysiloxanes such as diphenylsiloxyphenyl trimethicone. From the viewpoints of forming fine particles of oils containing ceramides, improving storage stability, improving the smoothness of the skin after application, and improving the moist feeling of the skin after application, the silicone oil preferably contains one or more types selected from linear dimethylpolysiloxane and branched siloxane, more preferably contains linear dimethylpolysiloxane, even more preferably contains one or more types selected from dimethylpolysiloxane (2cs) and dimethylpolysiloxane (6cs), and even more preferably contains dimethylpolysiloxane (2cs).

[0026] Examples of higher fatty acids include oleic acid, isostearic acid, and undecylenic acid.

[0027] The oil agent of component (B) preferably contains (B1) a hydrocarbon oil, (B2) a polar oil, and a silicone oil, and more preferably contains (B1) a hydrocarbon oil and (B2) a polar oil, from the viewpoints of forming fine particles of an oil containing ceramides, improving storage stability, and improving moist feeling on skin after application. The (B2) polar oil preferably contains one or more selected from ester oils, ether oils, and higher fatty acids, from the viewpoints of forming fine particles of oils containing ceramides, improving storage stability, improving smoothness of the skin after application, and improving moist feeling of the skin after application, and more preferably contains ester oils.

[0028] The content of component (B1) is preferably 0.1% by mass or more in the total composition, more preferably 0.3% by mass or more, even more preferably 0.5% by mass or more, even more preferably 1.5% by mass or more, preferably 5% by mass or less, more preferably 4% by mass or less, even more preferably 3% by mass or less, and even more preferably 2.5% by mass or less, from the viewpoint of making the oil containing ceramides into fine particles, improving storage stability, improving smoothness of the skin after application, and improving moisturizing feeling of the skin after application. The content of component (B1) is preferably 0.1 to 5% by mass in the total composition, more preferably 0.3 to 4% by mass, even more preferably 0.5 to 3% by mass, and even more preferably 1.5 to 2.5% by mass. The content of component (B1) is preferably 0.5 to 2.5% by mass in the total composition. The content of component (B2) is preferably 0.05% by mass or more in the total composition, more preferably 0.1% by mass or more, even more preferably 0.3% by mass or more, even more preferably 0.5% by mass or more, even more preferably 1.5% by mass or more, preferably 3.5% by mass or less, more preferably 2.8% by mass or less, even more preferably 2.5% by mass or less, even more preferably 2.3% by mass or less, and even more preferably 2.1% by mass or less. The content of component (B2) is preferably 0.05-3.5% by mass in the total composition, more preferably 0.1-2.8% by mass, even more preferably 0.3-2.5% by mass, even more preferably 0.5-2.3% by mass, and even more preferably 1.5-2.1% by mass. The content of component (B2) is preferably 0.3-3.5% by mass in the total composition, and more preferably 1.5-2.5% by mass.

[0029] In the present invention, when component (B) contains components (B1) and (B2), the mass ratio (B1) / (B2) of component (B1) to component (B2) is, from the viewpoints of forming oil containing ceramides into fine particles, improving storage stability, improving skin smoothness after application, and improving moist feeling of skin after application, preferably 0.05 or more, more preferably 0.1 or more, even more preferably 0.5 or more, still more preferably 0.7 or more, preferably 6 or less, more preferably 3 or less, even more preferably 2.5 or less, and still more preferably 2 or less. The mass ratio (B1) / (B2) of component (B1) to component (B2) is preferably 0.05 to 6, more preferably 0.1 to 3, even more preferably 0.5 to 2.5, and even more preferably 0.7 to 2. The mass ratio (B1) / (B2) of component (B1) to component (B2) is preferably 0.5 to 6, more preferably 0.7 to 3, and even more preferably 0.7 to 2.5.

[0030] One or more types of component (B) can be used, and from the viewpoints of forming the ceramide-containing oil into fine particles, improving storage stability, improving the smoothness of the skin after application, and improving the moist feeling of the skin after application, the content is preferably 0.15% by mass or more of the total composition, more preferably 1% by mass or more, even more preferably 3% by mass or more, even more preferably 5% by mass or more, and preferably 9% by mass or less, more preferably 7.5% by mass or less, even more preferably 7% by mass or less, and even more preferably 6.5% by mass or less. The content of component (B) in the entire composition is preferably 0.15 to 9 mass%, more preferably 1 to 7.5 mass%, even more preferably 3 to 7 mass%, and even more preferably 5 to 6.5 mass%. The content of component (B) in the entire composition is preferably 1 to 9 mass%.

[0031] In the present invention, the mass ratio (A) / (B) of component (A) to component (B) is, from the viewpoints of forming oil containing ceramides into fine particles, improving storage stability, improving skin smoothness after application, and improving moist feeling of skin after application, preferably 0.05 or more, more preferably 0.1 or more, even more preferably 0.12 or more, even more preferably 0.15 or more, preferably 1 or less, more preferably 0.4 or less, even more preferably 0.3 or less, and even more preferably 0.2 or less. The mass ratio (A) / (B) of component (A) to component (B) is preferably 0.05 to 1, more preferably 0.1 to 0.4, even more preferably 0.12 to 0.3, and even more preferably 0.15 to 0.2. The mass ratio (A) / (B) of component (A) to component (B) is preferably 0.05 to 0.4, and more preferably 0.05 to 0.3.

[0032] Component (C) is a nonionic surfactant having an HLB of less than 10. Here, HLB (Hydrophilic-Lipophilic Balance) indicates the molecular weight of the hydrophilic group portion in the total molecular weight of a surfactant, and in the present invention, for nonionic surfactants, it is calculated by Griffin's formula.

[0033]

[0043] The nonionic surfactant having an HLB of less than 10 is not limited as long as it is used in ordinary cosmetics, and examples thereof include silicone surfactants such as polyoxyethylene fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene alkyl ethers, polyoxyethylene sorbitol fatty acid esters, polyoxyethylene glycerin fatty acid esters, polyoxyethylene propylene glycol fatty acid esters, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, polyoxyethylene hydrogenated castor oil fatty acid esters, polyoxyethylene phytostanol ether, polyoxyethylene phytosterose ether, polyoxyethylene cholestanol ether, polyoxyethylene cholesteryl ether, and polyether-modified silicones, sucrose fatty acid esters, glycerin fatty acid esters, alkyl saccharides, alkyl glyceryl ethers, and sorbitan fatty acid esters.

[0034] From the viewpoint of forming oils containing ceramides into fine particles and improving storage stability, the nonionic surfactants having an HLB of less than 10 preferably have an HLB of 7 or less, more preferably 5 or less, and more preferably have an HLB of 1 or more, more preferably 3 or more. Of these, from the viewpoint of forming oils containing ceramides into fine particles and improving storage stability, it is preferable to include one or more selected from polyether-modified silicones, glycerin fatty acid esters, alkyl glyceryl ethers, and sorbitan fatty acid esters, more preferably to include one or more selected from glycerin fatty acid esters and sorbitan fatty acid esters, and even more preferably to include sorbitan fatty acid esters.

[0035] One or more types of component (C) can be used, and from the viewpoint of forming the ceramide-containing oil into fine particles and improving storage stability, the content is preferably 0.1 mass% or more of the total composition, more preferably 0.4 mass% or more, even more preferably 0.5 mass% or more, still more preferably 0.55 mass% or more, and preferably 3 mass% or less, more preferably 2.5 mass% or less, even more preferably 1.8 mass% or less, and still more preferably 1.4 mass% or less. The content of component (C) in the entire composition is preferably 0.1 to 3 mass%, more preferably 0.4 to 2.5 mass%, even more preferably 0.5 to 1.8 mass%, and even more preferably 0.55 to 1.4 mass%. The content of component (C) in the entire composition is preferably 0.1 to 2.5 mass%.

[0036] In the present invention, the mass ratio (A) / (C) of component (A) to component (C) is, from the viewpoints of forming oil containing ceramides into fine particles, improving storage stability and improving skin smoothness after application, and improving moist feeling of skin after application, preferably 0.05 or more, more preferably 0.1 or more, even more preferably 0.5 or more, even more preferably 0.6 or more, particularly preferably 0.8 or more, preferably 10 or less, more preferably 5 or less, even more preferably 2.5 or less, even more preferably 2.2 or less, and particularly preferably 1.8 or less. The mass ratio (A) / (C) of component (A) to component (C) is preferably 0.05 to 10, more preferably 0.1 to 5, even more preferably 0.5 to 2.5, even more preferably 0.6 to 2.2, and particularly preferably 0.8 to 1.8. The mass ratio (A) / (C) of component (A) to component (C) is preferably 0.1 to 10.

[0037] In the present invention, the mass ratio (B) / (C) of component (B) to component (C) is, from the viewpoints of forming oil containing ceramides into fine particles, improving storage stability and improving skin smoothness after application, and improving moist feeling of skin after application, preferably 0.05 or more, more preferably 1 or more, even more preferably 3 or more, even more preferably 3.5 or more, especially preferably 4.5 or more, preferably 40 or less, more preferably 20 or less, even more preferably 15 or less, even more preferably 12 or less, and especially preferably 10 or less. The mass ratio (B) / (C) of component (B) to component (C) is preferably 0.05 to 40, more preferably 1 to 20, even more preferably 3 to 15, even more preferably 3.5 to 12, and particularly preferably 4.5 to 10. The mass ratio (B) / (C) of component (B) to component (C) is preferably 1 to 40.

[0038] In the present invention, the content of water in component (D) is preferably 50% by mass or more, more preferably 60% by mass or more, and even more preferably 70% by mass or more, and is preferably 95% by mass or less, more preferably 90% by mass or less, and even more preferably 88% by mass or less, in terms of forming fine particles of oil containing ceramides, improving storage stability, improving smoothness of skin after application, and improving moist feeling of skin after application. The content of water in component (D) is preferably 50 to 95% by mass, more preferably 60 to 90% by mass, and even more preferably 70 to 88% by mass, in the entire composition.

[0039] The oil-in-water emulsion composition of the present invention may further contain a nonionic surfactant having an (E)HLB of 10 or more, which can convert the oil containing ceramides into fine particles and further improve storage stability. The nonionic surfactant of component (E) preferably has an HLB value of 11 to 16, and more preferably an HLB value of 12 to 15, from the viewpoints of forming oils containing ceramides into fine particles and improving storage stability.

[0040] Examples of the nonionic surfactant of component (E) include polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene alkanol ether, polyglycerin fatty acid ester, sucrose fatty acid ester, etc. Among these, from the viewpoint of forming oils containing ceramides into fine particles and improving storage stability, it is preferable to contain one or more selected from polyoxyethylene hydrogenated castor oil and polyoxyethylene sorbitan fatty acid ester, and it is more preferable to contain polyoxyethylene sorbitan fatty acid ester.

[0041] In addition, in the polyoxyethylene hydrogenated castor oil, the average number of moles of polyoxyethylene chains added that constitute the polyoxyethylene hydrogenated castor oil is preferably 25 to 100, more preferably 35 to 85, even more preferably 45 to 75, even more preferably 55 to 65, and particularly preferably 60, from the viewpoint of forming an oil containing ceramides into fine particles and improving storage stability.

[0042] In the polyoxyethylene sorbitan fatty acid ester, from the viewpoints of forming ceramide-containing oil into fine particles and improving storage stability, the average number of added moles of polyoxyethylene chains constituting the polyoxyethylene sorbitan fatty acid ester is preferably 10 to 30, more preferably 15 to 25, and even more preferably 20. In the polyoxyethylene sorbitan fatty acid ester, from the viewpoints of forming ceramide-containing oil into fine particles and improving storage stability, the average number of carbon atoms of the alkyl group constituting the polyoxyethylene sorbitan fatty acid ester is preferably 10 to 25, more preferably 16 to 20, and even more preferably 18.

[0043] The nonionic surfactant of component (E) can be used alone or in combination of two or more, and from the viewpoint of forming the oil containing ceramides into fine particles and improving storage stability, the content is preferably 0.5% by mass or more in the total composition, more preferably 1% by mass or more, even more preferably 1.4% by mass or more, preferably 3% by mass or less, more preferably 2.5% by mass or less, and even more preferably 2% by mass or less. The content of component (E) is preferably 0.5 to 3% by mass in the total composition, more preferably 1 to 2.5% by mass, and even more preferably 1.4 to 2% by mass.

[0044] The oil-in-water emulsion composition of the present invention may further contain an ionic surfactant, which can turn the oil containing ceramides into fine particles and improve storage stability. Examples of the ionic surfactant include anionic surfactants, cationic surfactants, and amphoteric surfactants. Examples of the anionic surfactant include fatty acids having 12 to 22 carbon atoms or salts thereof, such as sodium laurate, potassium palmitate, and arginine stearate; C12-C22 alkyl sulfates or salts thereof, such as sodium lauryl sulfate, potassium lauryl sulfate, and sodium cetyl sulfate; C12-C22 alkyl ether sulfates or salts thereof, such as polyoxyethylene lauryl sulfate triethanolamine; Acyl sarcosine having 12 to 22 carbon atoms or a salt thereof, such as sodium lauroyl sarcosine; C12-C22 alkyl phosphate or a salt thereof, such as sodium monostearyl phosphate; Polyoxyethylene alkyl ether phosphates having 12 to 22 carbon atoms, such as sodium polyoxyethylene oleyl ether phosphate and sodium polyoxyethylene stearyl ether phosphate, or salts thereof; Dialkyl sulfosuccinic acids having 12 to 24 carbon atoms or salts thereof, such as sodium di-2-ethylhexyl sulfosuccinate; N-alkyloylmethyltaurines having 12 to 22 carbon atoms or salts thereof, such as sodium N-stearoyl-N-methyltaurate; Examples of the acyl glutamic acids include N-acyl glutamic acids having 12 to 22 carbon atoms or salts thereof, such as sodium dilauroyl glutamate, monosodium N-lauroyl glutamate, sodium N-stearoyl-L-glutamate, arginine N-stearoyl-L-glutamate, sodium N-stearoyl glutamate, and sodium N-myristoyl-L-glutamate. As the N-alkyloylmethyltaurine having 12 to 22 carbon atoms or a salt thereof, sodium N-stearoyl-N-methyltaurine is preferred from the viewpoint of forming oil containing ceramides into fine particles and improving storage stability. As the N-acylglutamic acid having 12 to 22 carbon atoms or a salt thereof, sodium N-stearoyl-L-glutamate is preferred from the viewpoint of forming oil containing ceramides into fine particles and improving storage stability. In addition, sodium N-stearoyl-N-methyl taurine is also written as stearoyl methyl taurine, and sodium N-stearoyl-L-glutamate is also written as sodium stearoyl glutamate.

[0045] As the cationic surfactant, a quaternary ammonium salt is preferable, and examples thereof include alkyltrimethylammonium chlorides such as stearyltrimethylammonium chloride and behenyltrimethylammonium chloride, dialkyldimethylammonium chloride, trialkylmethylammonium chloride, and alkylamine salts.

[0046] Furthermore, examples of amphoteric surfactants include alkyldimethylamine oxides, alkylcarboxybetaines, alkylsulfobetaines, amide amino acid salts, and alkylamidopropylbetaines, with alkylamidopropylbetaines being preferred among them.

[0047] As the ionic surfactant, from the viewpoint of forming the oil containing ceramides into fine particles and improving storage stability, it is preferable to include an anionic surfactant. In addition, from the viewpoint of forming oils containing ceramides into fine particles and improving storage stability, the anionic surfactant preferably contains one or more selected from N-alkyloylmethyltaurine having 12 to 22 carbon atoms or a salt thereof, and N-acylglutamic acid having 12 to 22 carbon atoms or a salt thereof, more preferably N-alkyloylmethyltaurine having 12 to 22 carbon atoms or a salt thereof, and even more preferably N-stearoyl-N-methyltaurine or a salt thereof.

[0048] Ionic surfactants can be used alone or in combination of two or more, and from the viewpoint of making oils containing ceramides into fine particles and improving storage stability, the content is preferably 0.05% by mass or more in the total composition, more preferably 0.1% by mass or more, even more preferably 0.13% by mass or more, even more preferably 0.15% by mass or more, even more preferably 0.18% by mass or more, preferably 2% by mass or less, more preferably 1% by mass or less, even more preferably 0.8% by mass or less, even more preferably 0.5% by mass or less, and even more preferably 0.45% by mass or less. The content of the ionic surfactant is preferably 0.05 to 2% by mass in the total composition, more preferably 0.1 to 1% by mass, even more preferably 0.13 to 0.8% by mass, even more preferably 0.15 to 0.5% by mass, and even more preferably 0.18 to 0.45% by mass. The content of the ionic surfactant is preferably from 0.1 to 2% by mass, and more preferably from 0.1 to 0.8% by mass.

[0049] The oil-in-water emulsion composition of the present invention may further contain a polyhydric alcohol, which can convert the oil containing ceramides into fine particles and improve storage stability. The polyhydric alcohol is a compound having two or more hydroxyl groups in the molecule, and may be any of those used in ordinary cosmetics. Examples of dihydric alcohols include ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, polypropylene glycol, 1,3-butylene glycol, 1,3-propanediol, and pentanediol. Examples of trihydric alcohols include glycerin and trimethylolpropane. Examples of tetrahydric alcohols include diglycerin and erythritol. Examples of polyhydric alcohols having a valence of five or more include polyglycerins such as triglycerin; sugars and sugar alcohols such as glucose, maltose, maltose, sucrose, xylitol, sorbitol, maltitol, polyoxyethylene methyl glucoside, polyoxyethylene ethyl glucoside, and polyoxyethylene propylene glucoside. Of these, from the viewpoint of forming fine particles of an oil containing ceramides and improving storage stability, it is preferable to contain one or more selected from dihydric alcohols and trihydric alcohols, more preferably to contain a dihydric alcohol, and even more preferably to contain one or more selected from 1,3-butylene glycol and dipropylene glycol.

[0050] The polyhydric alcohol may be used alone or in combination of two or more, and from the viewpoint of forming the oil containing ceramides into fine particles and improving storage stability, the content is preferably 1% by mass or more in the total composition, more preferably 1.3% by mass or more, even more preferably 1.5% by mass or more, even more preferably 1.8% by mass or more, preferably 30% by mass or less, more preferably 20% by mass or less, even more preferably 15% by mass or less, and even more preferably 12% by mass or less. The content of the polyhydric alcohol is preferably 1 to 30% by mass in the total composition, more preferably 1.3 to 20% by mass, even more preferably 1.5 to 15% by mass, and even more preferably 1.8 to 12% by mass. In addition, when the polyhydric alcohol contains a dihydric alcohol, the dihydric alcohol can be used alone or in combination of two or more kinds, and from the viewpoint of forming the oil containing ceramides into fine particles and improving storage stability, the content is preferably 1% by mass or more in the total composition, more preferably 1.3% by mass or more, even more preferably 1.5% by mass or more, even more preferably 1.8% by mass or more, preferably 30% by mass or less, more preferably 20% by mass or less, even more preferably 15% by mass or less, and even more preferably 10% by mass or less. In addition, the content of the dihydric alcohol is preferably 1 to 30% by mass in the total composition, more preferably 1.3 to 20% by mass, even more preferably 1.5 to 15% by mass, and even more preferably 1.8 to 10% by mass.

[0051] The oil-in-water emulsion composition of the present invention may contain, in addition to the above-mentioned components, components that are usually used in cosmetics, such as oil components other than component (B), water-soluble polymers, antioxidants, fragrances, preservatives, pH adjusters, blood circulation promoters, cooling agents, antiperspirants, bactericides, skin activators, moisturizers other than polyhydric alcohols, cooling agents, colorants, etc.

[0052] The method for producing the oil-in-water emulsion composition of the present invention includes step 1 of obtaining an oil phase containing component (A), component (B), and component (C), and step 2 of mixing the oil phase obtained in step 1 with an aqueous phase containing component (D). From the viewpoint of obtaining a fine emulsion, the oil-in-water emulsion composition of the present invention preferably contains a dihydric alcohol. In that case, a preferred production method for the oil-in-water emulsion composition includes step 1 of obtaining an oil phase containing component (A), component (B), component (C), the dihydric alcohol, and a portion of component (D), and step 2 of mixing the oil phase obtained in step 1 with an aqueous phase containing the remainder of component (D). In step 1, it is preferable from the viewpoint of obtaining a fine emulsion that the oil phase contains a dihydric alcohol and a part of the water of component (D) and the oil phase obtained in step 1 is visually transparent (at the temperature during mixing). In this case, the content of the dihydric alcohol in the oil phase in step 1 is preferably 5% by mass or more, more preferably 8% by mass or more, from the viewpoint of obtaining a fine emulsion, and from the same viewpoint, it is preferably 30% by mass or less, more preferably 25% by mass or less. In addition, the content of the water of component (D) in the oil phase in step 1 is preferably 2% by mass or more, more preferably 5% by mass or more, from the viewpoint of obtaining a fine emulsion, and from the same viewpoint, it is preferably 10% by mass or less, more preferably 8% by mass or less.

[0053] The content of component (A) in the oil phase in step 1 is preferably 1% by mass or more, more preferably 2% by mass or more, from the viewpoint of improving the moist feeling of the skin after application, and is preferably 15% by mass or less, more preferably 13% by mass or less, from the viewpoint of obtaining a fine emulsion. The content of component (B) in the oil phase in step 1 is preferably 20% by mass or more, more preferably 30% by mass or more, from the viewpoint of improving the moist feeling of the skin after application, and is preferably 90% by mass or less, more preferably 80% by mass or less, from the viewpoint of obtaining a fine emulsion. The content of component (C) in the oil phase in step 1 is preferably 2% by mass or more, more preferably 3% by mass or more, from the viewpoint of obtaining a fine emulsion, and is preferably 30% by mass or less, more preferably 20% by mass or less, from the viewpoint of obtaining a fine emulsion.

[0054] The oil phase in step 1 may contain, as other components, component (E) and other surfactants, etc. The aqueous phase may contain, as other components, polyhydric alcohols other than dihydric alcohols, such as glycerin, etc. In step 2, from the viewpoint of obtaining a fine emulsion, it is preferable to heat and mix the oil phase and aqueous phase obtained in step 1 to preferably 60° C. or higher, more preferably 70° C. or higher, and preferably 100° C. or lower. Also, from the viewpoint of obtaining a fine emulsion, it is preferable to add the oil phase of step 1 to the aqueous phase and mix them. In step 2, the mixing mass ratio of the oil phase to the aqueous phase (oil phase / aqueous phase) is preferably 2 / 98 or more, more preferably 5 / 95 or more, from the viewpoint of productivity, and is preferably 40 / 60 or less, more preferably 30 / 70 or less, from the viewpoint of obtaining a fine emulsion. After mixing the oil phase and the water phase, it is preferable to stir the mixture for 10 minutes or more and 2 hours or less, and then cool the mixture to room temperature. For the mixing, a normal stirring device using a stirring blade can be used.

[0055] Furthermore, from the viewpoint of forming the ceramide-containing oil into fine particles and improving the storage stability, the oil-in-water emulsion composition of the present invention has a Z-average particle size of the emulsion particles of 0.05 to 0.3 μm, preferably 0.05 to 0.25 μm, more preferably 0.05 to 0.2 μm, and even more preferably 0.05 to 0.15 μm. In the present invention, the Z-average particle size of the emulsion particles is measured by diluting each oil-in-water emulsion composition 20 times and using a Zetasizer Nano Z manufactured by Malvern at 25° C. The cell used is 10×10×45 mm manufactured by Sarstedt. By making the particle size finer, the viscosity of the oil-in-water emulsion composition of the present invention can be made low. As a result, when the oil-in-water emulsion composition of the present invention is used as a makeup remover as described below, the oil-in-water emulsion composition is easily impregnated into cotton when applied to the cotton, and makeup stains can be removed without the cotton sliding on the skin when wiping the face.

[0056] The oil-in-water emulsion composition of the present invention is suitable as an oil-in-water emulsion cosmetic. For example, it can be used as a skin care cosmetic such as a lotion, milky lotion, or serum, or as a skin cosmetic such as a makeup remover. The oil-in-water emulsion composition of the present invention is suitable as a makeup remover because it converts oil containing ceramides into fine particles that are easily absorbed when applied to cotton. The oil-in-water emulsion composition of the present invention can be used by applying the composition to the skin with the fingers, or by impregnating a cotton pad or sheet with the composition and wiping the skin. When used as a makeup remover, it is preferable to impregnate a cotton pad with the composition. When the oil-in-water emulsion composition of the present invention is used as a makeup remover, from the viewpoint of facilitating impregnation of cotton with the oil-in-water emulsion composition, the viscosity at 25° C. is preferably from 10 to 3,000 mPa s, more preferably from 10 to 1,000 mPa s, and even more preferably from 10 to 400 mPa s. The viscosity of the oil-in-water emulsion composition of the present invention is measured using a Brookfield viscometer under the following measurement conditions. The measurement temperature is 25°C in all cases. For viscosity between 1 mPa·s and 200 mPa·s: Rotor No. 1, 30 rpm, 30 seconds, For viscosity between 200 mPa·s and 500 mPa·s: Rotor No. 1, 12 rpm, 30 seconds, For viscosity between 500 mPa·s and 2500 mPa·s: Rotor No. 2, 12 rpm, 30 seconds, For viscosity between 2500 mPa·s and 10000 mPa·s: Rotor No. 3, 12 rpm, 30 sec.

[0057] In relation to the above-mentioned embodiment, the present invention further discloses the following composition, production method, etc.

[0058] <1> The following components (A), (B), (C) and (D): (A) Ceramides, (B) An oil that is liquid at 25°C. (C) a nonionic surfactant having an HLB value of less than 10; (D)Water and wherein the Z-average particle size of the emulsion particles is 0.05 to 0.3 μm.

[0059] <2> The ceramides of component (A) are preferably natural ceramides, sphingosines, or ceramides represented by the above general formulas (1) and (2):

[0060] [ka]

[0061] [In the formula, R 1b is a hydrocarbon group having 10 to 26 carbon atoms, R 2b represents a hydrocarbon group having 9 to 25 carbon atoms, and X is -(CH2) n - (where n is an integer from 2 to 6).

[0062] [ka]

[0063] (In the formula, R 1 and R 2 are the same or different and each represents a hydrocarbon group having 1 to 40 carbon atoms which may be hydroxylated, and R 3 represents an alkylene group having 1 to 6 carbon atoms or a single bond; R 4 represents a hydrogen atom, an alkoxy group having 1 to 12 carbon atoms, or a 2,3-dihydroxypropyloxy group, provided that R 3 When is a single bond, R 4 is a hydrogen atom.) It is preferable to include one or more compounds selected from the compounds represented by It is more preferable that the composition contains one or more selected from natural ceramides, sphingosines, and compounds represented by the general formula (1), and it is even more preferable that the composition contains one or more selected from natural ceramides, phytosphingosine, and N-(hexadecyloxyhydroxypropyl)-N-hydroxyethylhexadecanamide, and it is even more preferable that the composition contains N-(hexadecyloxyhydroxypropyl)-N-hydroxyethylhexadecanamide. <1> The oil-in-water emulsion composition described above.

[0064] <3> The content of component (A) in the entire composition is preferably 0.5% by mass or more, more preferably 0.6% by mass or more, even more preferably 0.7% by mass or more, even more preferably 0.8% by mass or more, and is preferably 3% by mass or less, more preferably 2% by mass or less, even more preferably 1.8% by mass or less, and even more preferably 1.3% by mass or less. <1> or <2> The oil-in-water emulsion composition described above.

[0065] <4> The oil of component (B) is preferably one or more selected from the group consisting of hydrocarbon oils, ester oils, ether oils, higher alcohols, silicone oils, and higher fatty acids, It is more preferable that the composition contains (B1) a hydrocarbon oil, (B2) a polar oil, and a silicone oil, and it is even more preferable that the composition contains (B1) a hydrocarbon oil and (B2) a polar oil. <1> ~ <3> 10. The oil-in-water emulsion composition according to claim 1 . <5> The content of component (B1) is preferably 0.1% by mass or more in the total composition, more preferably 0.3% by mass or more, even more preferably 0.5% by mass or more, even more preferably 1.5% by mass or more, and is preferably 5% by mass or less, more preferably 4% by mass or less, even more preferably 3% by mass or less, and even more preferably 2.5% by mass or less. <4> The oil-in-water emulsion composition described above. <6> The content of component (B2) is preferably 0.05% by mass or more in the total composition, more preferably 0.1% by mass or more, even more preferably 0.3% by mass or more, even more preferably 0.5% by mass or more, particularly preferably 1.5% by mass or more, preferably 3.5% by mass or less, more preferably 2.8% by mass or less, even more preferably 2.5% by mass or less, even more preferably 2.3% by mass or less, and particularly preferably 2.1% by mass or less. <4> or <5> The oil-in-water emulsion composition described above.

[0066] <7> The component (B) preferably contains components (B1) and (B2), and the mass ratio (B1) / (B2) of the component (B1) to the component (B2) is preferably 0.05 or more, more preferably 0.1 or more, even more preferably 0.5 or more, even more preferably 0.7 or more, and is preferably 6 or less, more preferably 3 or less, even more preferably 2.5 or less, and even more preferably 2 or less. <4> ~ <6> 10. The oil-in-water emulsion composition according to claim 1 .

[0067] <8> The content of component (B) in the entire composition is preferably 0.15% by mass or more, more preferably 1% by mass or more, even more preferably 3% by mass or more, even more preferably 5% by mass or more, and is preferably 9% by mass or less, more preferably 7.5% by mass or less, even more preferably 7% by mass or less, and even more preferably 6.5% by mass or less. <1> ~ <7> 10. The oil-in-water emulsion composition according to claim 1 . <9> The mass ratio (A) / (B) of the component (A) to the component (B) is preferably 0.05 or more, more preferably 0.1 or more, even more preferably 0.12 or more, even more preferably 0.15 or more, and is preferably 1 or less, more preferably 0.4 or less, even more preferably 0.3 or less, and even more preferably 0.2 or less. <1> ~ <8> 10. The oil-in-water emulsion composition according to claim 1 .

[0068] <10> The component (C) preferably has an HLB of 7 or less, more preferably 5 or less, and preferably has an HLB of 1 or more, more preferably 3 or more. <1> ~ <9> 10. The oil-in-water emulsion composition according to claim 1 . <11> The component (C) preferably contains one or more selected from polyether-modified silicone, glycerin fatty acid ester, alkyl glyceryl ether, and sorbitan fatty acid ester, more preferably contains one or more selected from glycerin fatty acid ester and sorbitan fatty acid ester, and further preferably contains sorbitan fatty acid ester. <1> ~ <10> 10. The oil-in-water emulsion composition according to claim 1 . <12> The content of component (C) in the entire composition is preferably 0.1% by mass or more, more preferably 0.4% by mass or more, even more preferably 0.5% by mass or more, still more preferably 0.55% by mass or more, and is preferably 3% by mass or less, more preferably 2.5% by mass or less, even more preferably 1.8% by mass or less, and still more preferably 1.4% by mass or less. <1> ~ <11> 10. The oil-in-water emulsion composition according to claim 1 .

[0069] <13> The mass ratio (A) / (C) of component (A) to component (C) is preferably 0.05 or more, more preferably 0.1 or more, even more preferably 0.5 or more, even more preferably 0.6 or more, and particularly preferably 0.8 or more, and is preferably 10 or less, more preferably 5 or less, even more preferably 2.5 or less, even more preferably 2.2 or less, and particularly preferably 1.8 or less. <1> ~ <12> 10. The oil-in-water emulsion composition according to claim 1 . <14> The mass ratio (B) / (C) of component (B) to component (C) is preferably 0.05 or more, more preferably 1 or more, even more preferably 3 or more, even more preferably 3.5 or more, and particularly preferably 4.5 or more, and is preferably 40 or less, more preferably 20 or less, even more preferably 15 or less, even more preferably 12 or less, and particularly preferably 10 or less. <1> ~ <13> 10. The oil-in-water emulsion composition according to claim 1 .

[0070] <15> The content of water in the component (D) is preferably 50% by mass or more, more preferably 60% by mass or more, and even more preferably 70% by mass or more, and is preferably 95% by mass or less, more preferably 90% by mass or less, and even more preferably 88% by mass or less, based on the total composition. <1> ~ <14> 10. The oil-in-water emulsion composition according to claim 1 .

[0071] <16> Furthermore, it is preferable that the composition further contains (E) a nonionic surfactant having an HLB of 10 or more, more preferably an HLB of 11 to 16, and even more preferably an HLB of 12 to 15. <1> ~ <15> 10. The oil-in-water emulsion composition according to claim 1 . <17> The nonionic surfactant of component (E) preferably contains at least one selected from polyoxyethylene hydrogenated castor oil and polyoxyethylene sorbitan fatty acid ester, and more preferably contains polyoxyethylene sorbitan fatty acid ester. <16> The oil-in-water emulsion composition described above.

[0072] <18> In the polyoxyethylene hydrogenated castor oil, the average number of moles of polyoxyethylene chains added that constitute the polyoxyethylene hydrogenated castor oil is preferably 25 to 100, more preferably 35 to 85, even more preferably 45 to 75, even more preferably 55 to 65, and particularly preferably 60. <17> The oil-in-water emulsion composition described above. <19> In the polyoxyethylene sorbitan fatty acid ester, the average number of moles of polyoxyethylene chains added that constitute the polyoxyethylene sorbitan fatty acid ester is preferably 10 to 30, more preferably 15 to 25, and even more preferably 20, and the number of carbon atoms in the alkyl group is preferably 10 to 25, more preferably 16 to 20, and even more preferably 18. <17> The oil-in-water emulsion composition described above.

[0073] <20> The content of component (E) is preferably 0.5% by mass or more, more preferably 1% by mass or more, and even more preferably 1.4% by mass or more, and is preferably 3% by mass or less, more preferably 2.5% by mass or less, and even more preferably 2% by mass or less, based on the total composition. <16> ~ <19> 10. The oil-in-water emulsion composition according to claim 1 .

[0074] <21> Further, it is preferable that the composition contains an ionic surfactant, and more preferable that the composition contains an anionic surfactant. More preferably, the compound contains one or more selected from the group consisting of N-alkyloylmethyltaurine having 12 to 22 carbon atoms or a salt thereof, and N-acylglutamic acid having 12 to 22 carbon atoms or a salt thereof. More preferably, the composition contains N-alkyloylmethyltaurine having 12 to 22 carbon atoms or a salt thereof, and even more preferably, N-stearoyl-N-methyltaurine or a salt thereof. <1> ~ <20> 10. The oil-in-water emulsion composition according to claim 1 . <22> The content of the ionic surfactant is preferably 0.05% by mass or more in the total composition, more preferably 0.1% by mass or more, even more preferably 0.13% by mass or more, even more preferably 0.15% by mass or more, and particularly preferably 0.18% by mass or more, and is preferably 2% by mass or less, more preferably 1% by mass or less, even more preferably 0.8% by mass or less, even more preferably 0.5% by mass or less, and particularly preferably 0.45% by mass or less. <21> The oil-in-water emulsion composition described above.

[0075] <23> Further, it is preferable that the composition contains a polyhydric alcohol, more preferably contains one or more selected from dihydric alcohols and trihydric alcohols, even more preferably contains a dihydric alcohol, and even more preferably contains one or more selected from 1,3-butylene glycol and dipropylene glycol. <1> ~ <22> 10. The oil-in-water emulsion composition according to claim 1 . <24> The content of the polyhydric alcohol is preferably 1% by mass or more, more preferably 1.3% by mass or more, even more preferably 1.5% by mass or more, even more preferably 1.8% by mass or more, and is preferably 30% by mass or less, more preferably 20% by mass or less, even more preferably 15% by mass or less, and even more preferably 12% by mass or less, based on the total composition. <23> The oil-in-water emulsion composition described above.

[0076] <25> When the polyhydric alcohol contains a dihydric alcohol, the content of the dihydric alcohol is preferably 1% by mass or more, more preferably 1.3% by mass or more, even more preferably 1.5% by mass or more, even more preferably 1.8% by mass or more, and is preferably 30% by mass or less, more preferably 20% by mass or less, even more preferably 15% by mass or less, and even more preferably 10% by mass or less, based on the total composition. <23> or <24> The oil-in-water emulsion composition described above.

[0077] <26> The Z-average particle size of the emulsion particles is preferably 0.05 to 0.25 μm, more preferably 0.05 to 0.2 μm, and even more preferably 0.05 to 0.15 μm. <1> ~ <25> 10. The oil-in-water emulsion composition according to claim 1 . <27> Preferably, the cosmetic is an oil-in-water emulsion cosmetic. <1> ~ <26> 10. The oil-in-water emulsion composition according to claim 1 . <28> Take it in your hand and apply it to your skin with your fingers. <1> ~ <27> 10. The oil-in-water emulsion composition according to claim 1 . <29> It is soaked into cotton or a sheet and used by wiping the skin. <1> ~ <27> 10. The oil-in-water emulsion composition according to claim 1 .

[0078] <30> The method includes a step 1 of obtaining an oil phase containing the components (A), (B), and (C), and a step 2 of mixing the oil phase obtained in the step 1 with an aqueous phase containing the component (D). <1> ~ <29> 1. A method for producing the oil-in-water emulsion composition according to any one of claims 1 to 9. <31> The oil-in-water emulsion composition contains a dihydric alcohol, and the method includes: step 1 of obtaining an oil phase containing component (A), component (B), component (C), the dihydric alcohol, and a part of component (D); and step 2 of mixing the oil phase obtained in step 1 with an aqueous phase containing the remainder of component (D). <30> A method for producing the oil-in-water emulsion composition described above. <32> The content of the dihydric alcohol in the oil phase in step 1 is preferably 5% by mass or more, more preferably 8% by mass or more, preferably 30% by mass or less, and more preferably 25% by mass or less. <31> A method for producing the oil-in-water emulsion composition described above. <33> The content of water in the component (D) is preferably 2% by mass or more, more preferably 5% by mass or more, preferably 10% by mass or less, more preferably 8% by mass or less in the oil phase in step 1. <30> ~ <32> 1. A method for producing the oil-in-water emulsion composition according to any one of claims 1 to 9.

[0079] <34> The content of component (A) in the oil phase in step 1 is preferably 1% by mass or more, more preferably 2% by mass or more, preferably 15% by mass or less, and more preferably 13% by mass or less. <30> ~ <33> 1. A method for producing the oil-in-water emulsion composition according to any one of claims 1 to 9. <35> The content of component (B) in the oil phase in step 1 is preferably 20% by mass or more, more preferably 30% by mass or more, and is preferably 90% by mass or less, more preferably 80% by mass or less. <30> ~ <34> 1. A method for producing the oil-in-water emulsion composition according to any one of claims 1 to 9. <36> The content of component (C) in the oil phase in step 1 is preferably 2% by mass or more, more preferably 3% by mass or more, and is preferably 30% by mass or less, more preferably 20% by mass or less. <30> ~ <35> 1. A method for producing the oil-in-water emulsion composition according to any one of claims 1 to 9.

[0080] <37> In step 2, the oil phase and the aqueous phase obtained in step 1 are heated to preferably 60° C. or higher, more preferably 70° C. or higher, and preferably 100° C. or lower, and mixed. <30> ~ <36> 1. A method for producing the oil-in-water emulsion composition according to any one of claims 1 to 9. <38> In step 2, the mixing mass ratio of the oil phase to the aqueous phase (oil phase / aqueous phase) is preferably 2 / 98 or more, more preferably 5 / 95 or more, and is preferably 40 / 60 or less, and more preferably 30 / 70 or less. <30> ~ <37> 1. A method for producing the oil-in-water emulsion composition according to any one of claims 1 to 9.

[0081] <39> The following components (A), (B), (C) and (D): (A) Ceramides, (B) An oil that is liquid at 25°C. (C) a nonionic surfactant having an HLB value of less than 10; (D) Water; and anionic surfactants and wherein the Z-average particle size of the emulsion particles is 0.05 to 0.3 μm.

[0082] <40> The following components (A), (B), (C) and (D): (A) Ceramides, (B) An oil that is liquid at 25°C. (C) a nonionic surfactant having an HLB value of less than 10; (D) Water; The average particle size of the emulsion particles is 0.05 to 0.3 μm, Component (B) is (B1) Hydrocarbon oils, and (B2) containing 0.05 to 3.5 mass% of a polar oil, An oil-in-water emulsion composition, in which the mass ratio (A) / (C) of component (A) to component (C) is 0.05 to 10.

[0083] <41> The following components (A), (B), (C) and (D): (A) Ceramides, (B) An oil that is liquid at 25°C. (C) a nonionic surfactant having an HLB value of less than 10; (D) Water; The average particle size of the emulsion particles is 0.05 to 0.3 μm, The oil-in-water emulsion composition further contains 0.05 to 2 mass % of one or more selected from sodium N-stearoyl-N-methyl taurate and sodium N-stearoyl-L-glutamate.

[0084] <42> The following components (A), (B), (C) and (D): (A) Ceramides, (B) An oil that is liquid at 25°C. (C) a nonionic surfactant having an HLB value of less than 10; (D) Water; The average particle size of the emulsion particles is 0.05 to 0.3 μm, Component (B) is (B1) Hydrocarbon oils, and (B2) containing 0.05 to 3.5 mass% of a polar oil, An oil-in-water emulsion composition, in which the mass ratio (A) / (B) of component (A) to component (B) is 0.05 to 1. EXAMPLES

[0085] Examples 1 to 19, Comparative Examples 1 to 2 Oil-in-water emulsion compositions having the compositions shown in Tables 1 to 4 were prepared, and the emulsion particle size immediately after preparation was measured. The stability (45°C, 2 weeks), the moist feeling and smoothness of the skin after application to the skin with a finger, and the moist feeling and smoothness of the skin after being soaked in cotton and applied to the skin were also evaluated. The results are shown in Tables 1 to 4. The oil-in-water emulsion compositions of Examples 1 to 19 can also be used as makeup removers.

[0086] (Manufacturing method) (1) Components (A) to (C), a portion of component (D) (0.94% by mass of the total component (D)), component (E), stearoyl methyl taurine, and 1,3-butylene glycol were uniformly mixed (150 rpm) at 80°C to prepare an oil phase. (2) The remaining water (99.06% by mass of the total of component (D)) and glycerin were uniformly mixed and dissolved at 80° C. to prepare an aqueous phase. (3) The oil phase obtained in (1) was added to the aqueous phase obtained in (2) at 80°C, mixed (300 rpm), stirred for 10 minutes, and then allowed to cool to room temperature (25°C) to obtain an oil-in-water emulsion composition.

[0087] (Evaluation method) (1)Particle size: Immediately after production, each oil-in-water emulsion composition was diluted 20 times, and the Z-average particle size of the emulsion particles was measured at 25°C using a Zetasizer Nano Z manufactured by Malvern. The Z-average particle size here was the average value of three measurements. The cell used was 10 x 10 x 45 mm long and manufactured by Sarstedt.

[0088] (2) Presence or absence of large particles: In the measurement results of (1), the ratio of particles 1 μm or larger based on the particle size distribution was evaluated according to the following criteria. 3: Less than 1%. 2: More than 1% but less than 5%. 1:5% or more.

[0089] (3) Stability (45℃, 2 weeks): 20 mL of each oil-in-water emulsion composition was placed in a 28 mL transparent glass container (Mighty Vial No. 6, Maruemu Co., Ltd.), sealed, and stored at 45° C. for 2 weeks, after which the appearance was evaluated according to the following criteria. 5: A uniform layer with no separation. 4: There is a slight cloudiness on the upper layer, but when you shake it lightly the cloudiness disappears and there is no problem in actual use. 3: There is separation of less than 1 mm in the upper layer, which can be visually confirmed even when shaking lightly. 2: There is separation of 1mm to 5mm in the upper layer, which can be confirmed by visual inspection even when shaking lightly. 1: There is a separation of 5 mm or more in the upper layer.

[0090] (4) Moisturizing and smooth feeling of skin after application (apply to skin with fingers): Three expert evaluators applied 0.5 mL of each oil-in-water emulsion composition to an area of ​​4 x 10 cm on the inside of the forearm with their fingers, and rubbed the composition into the skin with the index finger, middle finger, and ring finger for about 20 seconds. The skin's moisturizing and smoothness were then evaluated according to the following criteria. The results were shown as the total score given by the three expert evaluators.

[0091] (4-1) Moisturizing feeling: 5: Visibly moist. 4: Moist. 3: Slightly moist. 2: Not very moist. 1: Clearly not moist.

[0092] (4-2) Smoothness: 5: Visibly smooth. 4: Smooth. 3: Somewhat smooth. 2: Not very smooth. 1: Clearly not smooth.

[0093] (5) Moisturizing and smooth feeling of skin after application (apply to skin using cotton pad): Three expert evaluators applied 2 mL of each oil-in-water emulsion composition to cotton (3.5 x 6.5 cm, Beauty Works Daily Cotton, manufactured by Kanebo Cosmetics Co., Ltd.) and wiped an area of ​​4 x 10 cm on the inside of the forearm. The skin's moisturizing and smoothness were then evaluated using the same criteria as in (4-1) and (4-2). The results were shown as the total score given by the three expert evaluators.

[0094] [Table 1]

[0095] [Table 2]

[0096] [Table 3]

[0097] [Table 4]

[0098] *1: N-(hexadecyloxyhydroxypropyl)-N-hydroxyethylhexadecanamide; sphingolipid E ​​(Kao Corporation), *2: Hydrogenated polyisobutene; Pearleem EX (manufactured by NOF Corporation), *3: Neopentyl glycol dicaprate; Estemoll N-01 (manufactured by Nisshin Oillio Group Co., Ltd.), *4: Dimethylpolysiloxane; Silicone 2CS (manufactured by Shin-Etsu Chemical Co., Ltd.), *5: Sorbitan stearate (HLB: 4.7); Rheodol SP-S10V (Kao Corporation), *6 Polyoxyethylene (20EO) sorbitan stearate (HLB: 14.9); Rheodol TW-S120V (Kao Corporation), *7: Stearoyl methyl taurine; Nikkol SMT (manufactured by Nippon Surfactant Industries Co., Ltd.), *8: 1,3-butylene glycol; 1,3-butylene glycol (KH Neochem Co., Ltd.), *9: Isotridecyl isononanoate; Salacos 913 (manufactured by Nisshin Oillio Group Co., Ltd.), *10: Ceramide 2; CERAMIDE TIC-001 (manufactured by Takasago International Corporation), *11: Ceramide 3; CERAMIDE III (manufactured by Evonik Industries AG), *12: Squalane; NIKKOL Sugar Squalane (manufactured by Nikko Chemicals), *13: Isononyl isononanoate; Salacos 99 (manufactured by Nisshin Oillio Group Co., Ltd.), *14: Isostearyl isostearate; ISIS (manufactured by Kokyu Alcohol Kogyo Co., Ltd.), *15: Jojoba oil; refined jojoba oil (manufactured by Koei Kogyo Co., Ltd.), *16: Olive oil; Clopure OL (manufactured by Croda Japan Co., Ltd.), *17: Tri(capryl / capric acid)glyceryl; Coconard MT (manufactured by Kao Corporation), *18: Stearic acid monoglyceride (HLB: 3.5); Rheodol MS-60 (Kao Corporation), *19: Sodium stearoyl glutamate; Amisoft HS-11P (manufactured by Ajinomoto Co., Ltd.)

[0099] Formulation examples 1-3 (makeup remover) The oil-in-water emulsion cosmetics (makeup removers) shown in Table 5 were produced in the same manner as in Examples 1 to 19, and stably emulsified and dispersed the oil phase containing ceramides as fine particles, exhibiting excellent storage stability and makeup removing effects, as well as leaving the skin smooth and moisturized after application.

[0100] [Table 5]

Claims

1. The following components (A), (B), (C) and (D): (A) ceramides, (B) an oil agent that is liquid at 25°C; (C) a nonionic surfactant having an HLB of less than 10; (D) Water and wherein the Z-average particle size of the emulsion particles is 0.05 to 0.3 μm.

2. The oil-in-water emulsion composition according to claim 1, further comprising an anionic surfactant.

3. 3. The oil-in-water emulsion composition according to claim 1, wherein the mass ratio (A) / (C) of the component (A) to the component (C) is 0.1 to 5.

4. 3. The oil-in-water emulsion composition according to claim 1, wherein the mass ratio (B) / (C) of the component (B) to the component (C) is 1 to 20.

5. 3. The oil-in-water emulsion composition according to claim 1, wherein the component (B) comprises (B1) a hydrocarbon oil and (B2) a polar oil.

6. 3. The oil-in-water emulsion composition according to claim 1 or 2, further comprising (E) a nonionic surfactant having an HLB of 10 or more.

7. The following components (A), (B), (C) and (D): (A) ceramides, (B) an oil agent that is liquid at 25°C; (C) a nonionic surfactant having an HLB of less than 10; (D) water; and anionic surfactants and wherein the Z-average particle size of the emulsion particles is 0.05 to 0.3 μm.

8. 8. The oil-in-water emulsion composition according to claim 2 or 7, wherein the anionic surfactant comprises one or more selected from the group consisting of N-alkyloylmethyltaurine having 12 to 22 carbon atoms or a salt thereof, and N-acylglutamic acid having 12 to 22 carbon atoms or a salt thereof.

9. The oil-in-water emulsion composition according to claim 1 or 2, which is a makeup remover.

10. 2. A method for producing the oil-in-water emulsion composition according to claim 1, comprising: step 1 of obtaining an oil phase containing the components (A), (B), and (C); and step 2 of mixing the oil phase obtained in step 1 with an aqueous phase containing the component (D).

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