Treatment system

Abstract

To provide an information processing device that allows the capacity of a connected treater to be grasped and a treatment system capable of executing the method.SOLUTION: A treatment system for treating blood and / or coelomic fluid includes: a purifier having a membrane for separating a first space and a second space; a liquid feeding part for controlling the volume of the liquid in the sealed second space; a pressure measuring part for measuring the pressure in the sealed second space; and an estimation part for estimating the volume V0 of the second space. The estimation part estimates the volume V0 on the basis of the volume α and the pressure P of the liquid in the second space at at least two time points where the volume of the liquid differs.SELECTED DRAWING: Figure 1A

Description

[Technical field]

[0001] The present invention relates to a treatment system for treating blood and / or body cavity fluids. [Background technology]

[0002] Ascites, a type of body cavity fluid, can be treated by removing the fluid from the patient, removing pathogenic substances such as bacteria and cancer cells from it, concentrating it while leaving useful components such as albumin, and then returning the concentrate to the body. This is called cell-free and concentrated ascites reinfusion therapy.

[0003] In such treatments, a body cavity fluid treatment system is generally used (see Patent Document 1). [Prior art documents] [Patent documents]

[0004] [Patent Document 1] JP 2019-13492 A Summary of the Invention [Problem to be solved by the invention]

[0005] In the above-mentioned body cavity fluid treatment system and other blood treatment systems, various purifiers are used depending on the treatment contents and treatment methods. Since the internal capacity of each purifier is different, it is necessary to know the internal capacity of the purifier and adjust the treatment conditions such as the priming amount so as not to apply excessive pressure.

[0006] The present invention has been made in consideration of the above problems, and has an object to provide an information processing device that can grasp the capacity of a connected purifier, and a processing system that can execute the method. [Means for solving the problem]

[0007] That is, the present invention is as follows. [1] 1. A treatment system for treating blood and / or body cavity fluids, comprising: a purifier having a membrane separating a first space from a second space; A liquid delivery unit that controls the volume of liquid in the sealed second space; A pressure measuring unit that measures the pressure in the sealed second space; An estimation unit that estimates a volume V0 of the second space, The estimation unit estimates the volume V0 based on a volume α of the liquid in the second space and a pressure P at at least two points in time when the volume of the liquid is different. Processing system. [2] The estimation unit estimates the volume V0 by the following formula: V0 = (α2 P2 - α1 P1) / (P2 - P1) P1: Pressure in the second space before liquid is sent or discharged P2: Pressure in the second space after liquid is delivered or drained α1: Amount of liquid in the second space before liquid delivery or drainage α2: Amount of liquid in the second space after liquid delivery or drainage The processing system according to [1]. [3] a first flow path connecting the purifier and the pressure measuring unit; The estimation unit estimates the volume V0 by the following formula: V0=(α2·P2-α1·P1) / (P2-P1)-β P1: Pressure in the second space before liquid is sent or discharged P2: Pressure in the second space after liquid is delivered or drained α1: Amount of liquid in the second space before liquid delivery or drainage α2: Amount of liquid in the second space after liquid delivery or drainage β: Volume of the first flow channel The processing system according to [1]. [4] In a state in which the first space is filled with liquid, the estimation unit estimates the volume V0 based on a volume α of the liquid in the second space and a pressure P at least at two points in time. The processing system according to any one of [1] to [3]. [5] A sealing means is provided to keep the first space filled with liquid. The processing system according to any one of [1] to

[43] . [6] The estimation unit calculates the volume α of the liquid in the second space based on an operation of sending and / or draining the liquid. The processing system according to any one of [1] to [5]. [7] A weight scale is provided to calculate the volume α of the liquid in the second space. The processing system according to any one of [1] to [6]. [8] the liquid delivery unit repeatedly delivers and / or drains the liquid to the sealed second space, The estimation unit estimates the volume Vn of the second space a plurality of times in response to the repetition of the liquid transfer, and estimates an average value of the obtained plurality of volumes Vn as the volume V0. The processing system according to any one of [1] to [7]. [9] the liquid delivery unit repeatedly delivers and / or drains the liquid to the sealed second space, The estimation unit estimates the volume Vn of the second space a plurality of times in response to the repetition of the liquid transfer, and estimates the minimum value of the obtained plurality of volumes Vn as the volume V0. The processing system according to any one of [1] to [8].

[10] the liquid delivery unit repeatedly delivers and / or drains the liquid to the sealed second space, The pressure measurement unit measures the pressure P when a change in pressure in the sealed second space becomes less than a threshold value after the liquid is delivered and / or discharged. The processing system according to any one of [1] to [9].

[11] The liquid delivery unit controls the volume of the liquid so that a deformation of a first flow path connecting the purifier and the pressure measurement unit is equal to or smaller than a predetermined value. The processing system according to any one of [1] to

[10] .

[12] The purifier includes a filter. The processing system according to any one of [1] to

[11] .

[13] The pressure measuring unit is installed vertically above the purifier, The liquid delivery unit controls the volume of the liquid so that the liquid does not come into contact with the pressure measurement unit and the connection port of the purifier when estimating the volume V0. The processing system according to any one of [1] to

[12] .

[14] The second space is a space into which filtered blood and / or body cavity fluid permeates; The processing system according to any one of [1] to

[13] . Effect of the Invention

[0008] According to the present invention, it is possible to provide an information processing device capable of grasping the capacity of a connected purifier, and a processing system capable of executing the method. [Brief description of the drawings]

[0009] [Figure 1A] FIG. 1 is a schematic diagram illustrating one aspect of a processing system according to an embodiment of the present invention. [Figure 1B] FIG. 2 is a diagram illustrating an example of a hardware configuration of the information processing apparatus according to the present embodiment. [Figure 1C] FIG. 2 is a diagram illustrating an example of a functional block configuration of the information processing apparatus according to the present embodiment. [Figure 1D] 10 is a schematic diagram showing one state at a point in time when a predetermined amount of liquid is present in the second space in the purifier of the treatment system of the present embodiment. FIG. [Figure 1E] 13 is a schematic diagram illustrating another aspect of the purifier of the treatment system of the present embodiment at a point in time when a predetermined amount of liquid is present in the second space. FIG. [Diagram 2]13 shows an example of a flowchart of a process for estimating a volume V0. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0010] Hereinafter, an embodiment of the present invention (hereinafter referred to as "the present embodiment") will be described in detail with reference to the drawings as necessary, but the present invention is not limited to this, and various modifications are possible without departing from the gist of the present invention. In the drawings, the same elements are given the same reference numerals, and duplicated explanations will be omitted. Furthermore, positional relationships such as up, down, left, and right are based on the positional relationships shown in the drawings, unless otherwise specified. Furthermore, the dimensional ratios of the drawings are not limited to those shown in the drawings.

[0011] 1. Processing System 1A is a schematic diagram showing one aspect of the processing system of this embodiment. The processing system 1 of this embodiment is a processing system for processing blood and / or body cavity fluid, and includes a purifier having a membrane that separates a first space from a second space, a liquid delivery unit that controls the volume of liquid in the sealed second space, a pressure measurement unit that measures the pressure in the sealed second space, and an estimation unit that estimates the volume V0 of the second space, and the estimation unit estimates the volume V0 based on the volume α of the liquid in the second space and the pressure P at least at two points in time when the liquid volumes are different.

[0012] 1A, the processing system 1 of the present embodiment will be described in detail. First, the processing system 1 may include an unprocessed bag 10 as a storage unit for unprocessed blood and / or body cavity fluid, a filter 11, a concentrator 12, a processed bag 13 as a collection unit for blood and / or body cavity fluid after filtering and concentrating, and an information processing device 100. The information processing device 100 may include various functional units, such as a control unit 85, a pressure measurement unit 86, and an estimation unit 87, for executing processing in the processing system 1.

[0013] The configuration of the processing system 1 will be described below using ascites as an example of body cavity fluid, but the processing target of the processing system 1 of this embodiment is not limited to ascites, and the processing system 1 can also be applied to other body cavity fluids and blood.

[0014] The untreated bag 10 is, for example, a soft bag, and can contain ascites collected from a patient. During the presumptive treatment, the untreated bag 10 may contain a liquid such as physiological saline or water.

[0015] The filter 11 is an example of a purifier of this embodiment. In the following, the filter 11 will be described as a purifier whose volume V0 is estimated, but the purifier of this embodiment is not limited to the filter 11, and a concentrator 12 (described later) and the like can also be used as a purifier whose volume V0 is estimated.

[0016] The filter 11 has, for example, a cylindrical housing. The filter 11 has liquid passages 11a and 11b at both ends in the longitudinal direction (vertical direction) and two liquid passages 11c and 11d on the side. The filter 11 may remove a predetermined pathogenic substance such as bacteria or cancer cells and pass a predetermined useful component such as albumin. During the estimation process, liquids such as saline or water may pass through each space in the filter 11. In this specification, the up and down of the processing system 1 are based on the posture during normal use.

[0017] The filter 11 includes a filtration membrane 30 that removes predetermined pathogenic substances such as bacteria and cancer cells and allows predetermined useful components such as albumin to pass through. The filtration membrane 30 is composed of, for example, a number of hollow fiber membranes. A first space (internal space of the hollow fiber membrane) 30a on the primary side of the filtration membrane 30 communicates with the liquid passage ports 11a and 11b, and a second space (external space of the hollow fiber membrane) 30b on the secondary side of the filtration membrane 30 communicates with the liquid passage ports 11c and 11d. Here, the second space 30b becomes a space from which filtered blood and / or body cavity fluid seeps out during treatment of body cavity fluid or the like.

[0018] A connection port 46 for pressure measurement may be connected to the liquid passage port 11c of the filter 11 via a first flow path 45. A pressure measuring device such as a pressure sensor may be connected to the connection port 46 for pressure measurement and closed. That is, the first flow path 45 may transmit the pressure of the second space 30b of the filtration membrane 30 to the connection port 46 by the passage of a liquid or gas.

[0019] A gas may be sealed in a portion of the first flow path 45, or a drip chamber may be provided therein, thereby preventing liquid from coming into contact with the pressure measuring device at the connection port 46. The connection port 46 may be provided with a hydrophobic filter that allows air to pass through.

[0020] The concentrator 12 is an example of a purifier of this embodiment. The concentrator 12 has, for example, a cylindrical housing. The concentrator 12 has liquid passages 12a and 12b at both ends in the longitudinal direction (vertical direction) and two liquid passages 12c and 12d on the side. The concentrator 12 may, for example, remove water from ascites to concentrate it. Note that during the estimation process, liquids such as saline or water may pass through each space in the concentrator 12.

[0021] The concentrator 12 is equipped with a concentration membrane 40 that removes water from, for example, ascites and concentrates the fluid. The concentration membrane 40 is composed of, for example, a number of hollow fiber membranes. A first space (inner space of the hollow fiber membrane) 40a on the primary side of the concentration membrane 40 communicates with the liquid passage ports 12a and 12b, and a second space (outer space of the hollow fiber membrane) 40b on the secondary side of the concentration membrane 40 communicates with the liquid passage ports 12c and 12d.

[0022] In addition, although FIG. 1A does not show an embodiment in which an information processing device 100 or a pressure measuring device is connected to the concentrator 12, the information processing device 100 and a pressure measuring device may be connected to the concentrator 12 as in the case of the filter 11.

[0023] The treated bag 13 is, for example, a soft bag, and can contain concentrated ascites concentrated by the concentrator 12. The treated bag 13 may be placed at a lower position than the untreated bag 10. During presumptive treatment, the treated bag 13 may contain liquid such as saline or water that has passed through the concentrator 12.

[0024] The flow path 14 connects the untreated bag 10 and the filter 11. The upstream end of the flow path 14 is connected to the untreated bag 10, and the downstream end of the flow path 14 is connected to the liquid passage 11a of the filter 11. During the estimation process, a liquid such as physiological saline or water may flow from the untreated bag 10 to the liquid passage 11a of the filter 11 through the flow path 14. During the process of body cavity fluid, ascites may flow from the untreated bag 10 to the liquid passage 11a of the filter 11 through the flow path 14. The flow path 14 may be provided with a valve 41 for opening and closing the flow path 14. In this specification, the term "upstream side" refers to the upstream side during normal ascites process in which ascites flows through the filter 11 and the concentrator 12 in this order, and the term "downstream side" refers to the downstream side during normal ascites process.

[0025] The control unit 85, the pressure measurement unit 86, and the estimation unit 87 may be functional units included in an information processing device 100 included in the processing system 1. The information processing device 100 is not particularly limited, but examples thereof include computers such as tablets and personal computers.

[0026] 1B is a diagram showing an example of a hardware configuration of the information processing device 100. The information processing device 100 includes a processor 111 such as a CPU (Central Processing Unit) or a GPU (Graphical Processing Unit), a storage device 112 such as a memory, an HDD (Hard Disk Drive) and / or an SSD (Solid State Drive), a communication IF (Interface) 113 for performing wired or wireless communication, an input device 114 for accepting an input operation, and an output device 115 for outputting information. The input device 114 is, for example, a keyboard, a touch panel, a mouse, and / or a microphone. The output device 115 is, for example, a display, a touch panel, and / or a speaker.

[0027] FIG. 1C is a diagram showing an example of a functional block configuration of the information processing device 100. The information processing device 100 may include a control unit 85, a pressure measurement unit 86, and an estimation unit 87. The storage unit 130 can be realized by using a storage device 112 included in the information processing device 100. The control unit 85, the pressure measurement unit 86, and the estimation unit 87 can be realized by the processor 111 of the information processing device 100 executing a program stored in the storage device 112. The program can be stored in a storage medium. The storage medium storing the program may be a non-transitory computer readable storage medium. The non-transitory storage medium is not particularly limited, and may be, for example, a storage medium such as a USB memory or a CD-ROM.

[0028] In this embodiment, the control unit 85, the pressure measurement unit 86, and the estimation unit 87 may cooperate to estimate the volume V0 of the second space 30b of the purifier. Specifically, the control unit 85 of the processing system 1 controls the pump 51, which is an example of a liquid delivery unit, to deliver liquid to the second space 30b or to discharge liquid from the second space 30b, the pressure measurement unit 86 measures the pressure in the second space 30b before and after the delivery or before and after the discharge, and the estimation unit 87 estimates the volume V0 of the second space 30b based on the liquid volumes α1 and α2 and the pressures P1 and P2 at least at two points in time when the volumes of the liquid in the second space 30b are different.

[0029] The processing system 1 may include, for example, valves 41 and 19a as sealing means for filling the first space 30a with liquid. The valve 41 is an opening / closing means for the flow path 14 connected to the liquid passage port 11a of the filter 11, and the valve 19a is an opening / closing means for the flow path 19 connected to the liquid passage port 11b of the filter 11. In this case, the control unit 85 may perform the above estimation process with the valves 41 and 19a closed, or may perform the above estimation process with the valves 41 and 19a open.

[0030] The control unit 85 controls the pump 51, which is an example of a liquid sending unit, to control the sending of liquid to the second space 30b of the filter 11 (purifier) ​​or the drainage of liquid from the second space 30b, and may also control the opening and closing of the valves 41 and 19a to control the flow of liquid into and out of the first space 30a. In addition, although not shown, the control unit 85 can control the operation of each device, such as the pump 60, the valve 50, the backflow prevention unit 65, and the valve 70, to perform processing of blood and / or body cavity fluid. The control unit 85 can realize each process by, for example, executing a program stored in a memory with a CPU.

[0031] The pressure measuring unit 86 is not particularly limited as long as it is configured to be able to measure the pressure in the second space 30b of the filter 11 (purifier). For example, the pressure measuring unit 86 may receive a signal related to pressure from a pressure measuring device directly connected to the second space 30b to measure the pressure in the second space 30b, or may receive a signal related to pressure from a pressure measuring device connected to the connection port 46 of the first flow path 45 connected to the second space 30b. In addition, a drip chamber (not shown), for example, may be connected to the first flow path 45.

[0032] The pressure measuring device constituting the pressure measuring unit 86 is installed vertically above the purifier, and the control unit 85 may control the volume of the liquid so that the liquid does not come into contact with the pressure measuring device of the pressure measuring unit 86 when the liquid delivery unit estimates the volume V0. This makes it possible to prevent the liquid from coming into contact with the pressure measuring device.

[0033] The estimation unit 87 estimates the volume V0 based on the liquid volume α and pressure P in the second space 30b at at least two points in time when the liquid volume is different. Here, Fig. 1D and Fig. 1E are schematic diagrams showing one aspect of a point in time when a predetermined amount of liquid is present in the second space in the purifier of the treatment system of this embodiment. In this embodiment, at at least two points in time when the liquid volume is different as shown in Fig. 1D and Fig. 1E, the estimation unit 87 estimates the volume V0 by the following formula. V0 = (α2 P2 - α1 P1) / (P2 - P1) P1: Pressure in the second space 30b before liquid delivery or drainage P2: Pressure in the second space 30b after liquid is sent or drained α1: Amount of liquid in the second space 30b before liquid transfer or drainage α2: Amount of liquid in the second space 30b after liquid transfer or drainage

[0034] 1A, in the case where a first flow path 45 that connects the filter 11 (purifier) ​​and the pressure measuring unit 86 is provided, the estimation unit 87 may take into account the volume in the first flow path 45 when estimating the volume V0. In this case, the estimation unit 87 may estimate the volume V0 by the following formula. This allows the volume V0 to be estimated more accurately. V0=(α2·P2-α1·P1) / (P2-P1)-β P1: Pressure in the second space 30b before liquid delivery or drainage P2: Pressure in the second space 30b after liquid is sent or drained α1: Amount of liquid in the second space 30b before liquid transfer or drainage α2: Amount of liquid in the second space 30b after liquid transfer or drainage β: Volume of the first flow path 45

[0035] The estimation unit 87 preferably estimates the volume V0 based on the volume α of the liquid in the second space and the pressure P at least at two points in time when the first space 30a is filled with liquid. By filling the first space 30a with liquid, the filtration membrane 30 is less likely to bend toward the first space 30a due to the liquid supplied to the second space 30b. This makes it possible to estimate the volume V0 more accurately.

[0036] In addition, the first space 30a is filled with liquid, and in this state, the control unit 85 controls the pump 51, which is an example of a liquid delivery unit, to control the delivery of liquid to the second space 30b of the filter 11 (purifier) ​​or the drainage of liquid from the second space 30b.

[0037] The estimation unit 87 may calculate the volume α of the liquid in the second space 30b based on the operation of sending and / or draining the liquid. Specifically, the estimation unit 87 may calculate the volume α of the liquid in the second space 30b at each time point based on the amount of liquid when the control unit 85 controls the liquid sending unit to send and / or drain the liquid to the second space 30b.

[0038] Alternatively, the treatment system 1 of this embodiment may include a weighing scale (not shown) that calculates the volume α of the liquid in the second space 30b. The weighing scale is not particularly limited, and may be, for example, a hanging scale, and the filter 11, which is a purifier, may be hung on a hook of the hanging scale to measure the volume α of the liquid in the second space 30b.

[0039] The memory unit 130 may have various data used in the estimation process of the volume V0, and may record, for example, data measured by the pressure measurement unit 86, the value of the volume V0 of the second space 30b estimated by the estimation unit 87, etc.

[0040] The flow path 15 connects the filter 11 and the concentrator 12. The upstream end of the flow path 15 is connected to the liquid passage 11d of the filter 11, and the downstream end of the flow path 15 is connected to the liquid passage 12a at the upper end of the concentrator 12. That is, the liquid passage 11d of the filter 11 is the outlet of the filter 11, and the liquid passage 12a of the concentrator 12 is the inlet of the concentrator 12. During the estimation process, a liquid such as physiological saline or water may flow from the concentrator 12 side to the filter 11 side in the direction F1 through the flow path 15. Furthermore, during the process of body cavity fluid, etc., filtered ascites may flow from the filter 11 side to the concentrator 12 side through the flow path 15. The filtered ascites may contain a predetermined useful component such as albumin.

[0041] In the flow path 15, for example, a valve 50, a pump 51, a drip chamber 52, a flow path 54, a pressure measuring device 53, a liquid bag 80, a valve 81, and a valve 82 may be provided in this order from the upstream side to the downstream side. The valve 50 is configured to be able to open and close the flow path 15.

[0042] The pump 51 is an example of a liquid delivery unit. The pump 51 is not particularly limited, but may be, for example, a tube pump that pumps liquid or gas in predetermined directions F1 and F2 by using a tube of the flow path 15, and may have a function as a blocking means for blocking the tube when the pump is stopped.

[0043] The pressure measuring device 53 communicates with the space 40a on the primary side of the concentrator 12 and is capable of measuring the pressure in this space 40a.

[0044] The liquid bag 80 is, for example, a soft bag, and is connected to the flow path 15. During the estimation process, the liquid bag 80 can introduce liquids such as physiological saline or water into the flow path 15. When introducing liquid, the physiological saline contained in the liquid bag 80 may be sent in the direction F1 by the pump 51. During the estimation process, the valve 82 may be closed so that the liquid is not sent to the concentrator 12. Furthermore, during normal ascites treatment, the valve 81 may be closed so that the treatment liquid does not flow back into the liquid bag 80.

[0045] The flow path 16 connects the concentrator 12 and the treated bag 13. The upstream end of the flow path 16 is connected to the liquid passage 12b at the lower end of the concentrator 12, and the downstream end of the flow path 16 is connected to the treated bag 13. In other words, the liquid passage 12b of the concentrator 12 serves as a first outlet of the concentrator 12.

[0046] A pump 60 may be provided in the flow path 16. The pump 60 may be a tube pump that pumps liquid through a tube in the flow path 16. The pump 60 may also function as a blocking means for blocking the tube when the pump is stopped.

[0047] An upstream end of the flow path 17 is connected to, for example, the liquid passage ports 12c and 12d of the concentrator 12. That is, the liquid passage ports 12c and 12d of the concentrator 12 serve as second outlets of the concentrator 12. The upstream end of the flow path 17 may be connected to only one of the liquid passage ports 12c and 12d. A downstream end of the flow path 17 may be connected to a drainage section (not shown) that receives the drainage liquid removed from the ascites by the concentrator 12. A backflow prevention section 65 may be provided in the flow path 17.

[0048] The flow path 18 connects the treated bag 13 and the flow path 15. One end (upstream end) of the flow path 18 is connected to the treated bag 13. The other end (downstream end) of the flow path 18 may be connected between the valve 50 and the pump 51 in the flow path 15. The flow path 18 may be provided with a valve 70 that opens and closes the flow path 18.

[0049] 2. Estimation process Next, the estimation process of the volume V0 according to the present embodiment will be described with reference to a flowchart. An example of the flowchart of the estimation process is shown in FIG.

[0050] In step S11, the control unit 85 controls the pump 51, which is a liquid delivery unit, to deliver a predetermined amount of liquid to the second space 30b through the flow path 15. At this time, the control unit 85 may close the valve 19a in advance to fill the first space 30a with liquid. Note that step S11 may be omitted.

[0051] At this time, the liquid delivery unit may control the volume of the liquid so that the deformation of the first flow path 45 connecting the purifier and the pressure measurement unit 86 is equal to or less than a predetermined value. As described above, the first flow path 45 may be a soft tube, and may be deformed depending on the pressures P1 and P2, causing the volume inside the tube to change. Since the change in the volume of the first flow path 45 causes an error in the calculation of the volume V0, the estimation accuracy of the volume V0 tends to be improved by controlling the volume of the liquid so that the deformation of the first flow path 45 is equal to or less than a predetermined value.

[0052] In step S12, the pressure measuring unit 86 measures the pressure P1 in the second space 30b, and the estimation unit 87 estimates the liquid amount α1 (see FIG. 1D). At this time, the estimation unit 87 may calculate the volume α1 of the liquid in the second space based on the operation of sending and / or draining the liquid, or may calculate the volume α1 of the liquid in the second space using a weight scale such as a hanging balance.

[0053] In step S13, the control unit 85 controls the pump 51, which is a liquid delivery unit, to deliver a predetermined amount of liquid to the second space 30b via the flow path 15, or to drain a predetermined amount of liquid from the second space 30b.

[0054] In step S14, the pressure measuring unit 86 measures the pressure P2 in the second space 30b, and the estimation unit 87 estimates the liquid amount α2 (see FIG. 1E). At this time, the estimation unit 87 may calculate the volume α2 of the liquid in the second space based on the operation of sending and / or draining the liquid, or may calculate the volume α2 of the liquid in the second space using a weight scale such as a hanging balance.

[0055] In step S15, the estimation unit 87 estimates the volume V0 based on the volume α of the liquid in the second space at least at two points in time when the volumes of the liquid are different and the pressure P. At this time, the estimation unit 87 may estimate the volume V0 taking into account the volume β of the first flow path.

[0056] Furthermore, the processing system of this embodiment may repeat steps S11 to S15, calculate the volume V of the second space 30b multiple times, and estimate the volume V0 based on the multiple estimated volumes V. For example, the control unit 85 may control the pump 51 or the like, which is a liquid delivery unit, and the control unit may repeatedly deliver and / or drain liquid to the sealed second space 30b, while the estimation unit 87 may estimate the volume Vn of the second space 30b multiple times in response to the repeated delivery of liquid, and estimate the average value of the multiple volumes Vn obtained as the volume V0. This allows the volume V0 to be estimated more accurately.

[0057] Alternatively, the control unit 85 may control the pump 51 or the like which is a liquid delivery unit, and the liquid delivery unit may repeatedly deliver and / or drain liquid to the sealed second space 30b, and the estimation unit 87 may estimate the volume Vn of the second space 30b multiple times in response to the repeated delivery of liquid, and estimate the minimum value of the multiple volumes Vn obtained as the volume V0. This makes it possible to avoid overestimating the volume V0. Therefore, it is possible to avoid supplying liquid to the processing machine in an amount exceeding the allowable amount based on the estimated volume V0.

[0058] Furthermore, the control unit 85 may control the pump 51 or the like which is the liquid delivery unit, so that the liquid delivery unit repeatedly delivers and / or drains liquid to the sealed second space, and the pressure measurement unit 86 may measure the pressure P when the pressure fluctuation in the sealed second space 30b becomes less than a threshold value after the liquid delivery and / or drainage. When the speed of liquid delivery to the sealed second space 30b is fast, there is a risk of a mismatch between the amount of liquid delivered and the change in pressure fluctuation. By doing as described above, this risk can be reduced.

[0059] With the treatment system 1 as described above, the capacity of the connected purifier can be easily ascertained, and treatment of body cavity fluid and the like can be performed based on that capacity. [Industrial Applicability]

[0060] The treatment system of the present invention has industrial applicability as a treatment system for treating blood and / or body cavity fluid. [Explanation of symbols]

[0061] 1 Treatment system, 10...untreated bag, 11...filter, 11a, 11b...passage port, 11c...passage port, 11d...passage port, 12...concentrator, 12a...passage port, 12b...passage port, 12c...passage port, 12d...passage port, 13...treated bag, 14...flow path, 15...flow path, 16...flow path, 17...flow path, 18...flow path, 19a...valve, 30...filtration membrane, 30a...first space, 30b...second space, 40...concentration membrane, 4 0a...first space, 40b...second space, 41...valve, 45...first flow path, 46...connection port, 50...valve, 51...pump, 52...drip chamber, 53...introduction section, 60...pump, 70...valve, 85...control section, 86...pressure measurement section, 87...estimation section, 100...information processing device, 111...processor, 112...storage device, 114...input device, 115...output device, 130...storage section.

Claims

1. 1. A treatment system for treating blood and / or body cavity fluids, comprising: a purifier having a membrane separating a first space from a second space; A liquid delivery unit that controls a volume of liquid in the sealed second space; a pressure measuring unit for measuring a pressure in the sealed second space; An estimation unit that estimates a volume V0 of the second space, The estimation unit estimates the volume V0 based on a volume α of the liquid in the second space and a pressure P at at least two points in time when the volumes of the liquid are different. Processing system.

2. The estimation unit estimates the volume V0 by the following formula: V0=(α2・P2−α1・P1) / (P2−P1) P1: pressure in the second space before liquid delivery or drainage P2: Pressure in the second space after liquid is sent or drained α1: Amount of liquid in the second space before liquid delivery or drainage α2: Amount of liquid in the second space after liquid transfer or drainage The processing system of claim 1 .

3. a first flow path connecting the purifier and the pressure measuring unit; The estimation unit estimates the volume V0 by the following formula: V0=(α2・P2−α1・P1) / (P2−P1)−β P1: pressure in the second space before liquid delivery or drainage P2: Pressure in the second space after liquid is sent or drained α1: Amount of liquid in the second space before liquid delivery or drainage α2: Amount of liquid in the second space after liquid transfer or drainage β: Volume of the first flow path The processing system of claim 1 .

4. In a state in which the first space is filled with liquid, the estimation unit estimates the volume V0 based on a volume α of the liquid in the second space and a pressure P at least at two points in time. The processing system of claim 1 .

5. a sealing means for keeping the first space filled with liquid; The processing system of claim 1 .

6. The estimation unit calculates the volume α of the liquid in the second space based on an operation of sending and / or draining the liquid. The processing system of claim 1 .

7. a weighing scale for calculating a volume α of the liquid in the second space; The processing system of claim 1 .

8. The liquid delivery unit repeatedly delivers and / or drains the liquid to the sealed second space, The estimation unit estimates the volume Vn of the second space a plurality of times in response to the repetition of the liquid transfer, and estimates an average value of the obtained plurality of volumes Vn as the volume V0. The processing system of claim 1 .

9. The liquid delivery unit repeatedly delivers and / or drains the liquid to the sealed second space, The estimation unit estimates the volume Vn of the second space a plurality of times in response to the repetition of the liquid transfer, and estimates the minimum value of the obtained plurality of volumes Vn as the volume V0. The processing system of claim 1 .

10. The liquid delivery unit repeatedly delivers and / or drains the liquid to the sealed second space, The pressure measurement unit measures the pressure P when a change in pressure in the sealed second space becomes less than a threshold value after the liquid is fed and / or discharged. The processing system of claim 1 .

11. The liquid delivery unit controls the volume of the liquid so that a deformation of a first flow path connecting the purifier and the pressure measurement unit is equal to or smaller than a predetermined value. The processing system of claim 1 .

12. The purifier includes a filter. The processing system of claim 1 .

13. The pressure measuring unit is installed vertically above the purifier, The liquid delivery unit controls the volume of the liquid so that the liquid does not come into contact with the pressure measurement unit and the connection port of the purifier when estimating the volume V0. The processing system of claim 1 .

14. The second space is a space into which filtered blood and / or body cavity fluid permeates. The processing system of claim 1 .

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