Compositions and methods for treating kit- and pdgfra-mediated diseases
JP2025029094AInactive Publication Date: 2025-03-05BLUEPRINT MEDICINES CORP
Patent Information
- Application Number
- JP2024210028
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2019-11-04
- Filing Date
- 2024-12-03
- Publication Date
- 2025-03-05
- Estimated Expiration
- Not applicable · inactive patent
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Figure 2025029094000001 
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Abstract
To provide novel pyrrolotriazine compounds and their use as selective inhibitors of activated KIT and PDGFRα mutant protein kinases.SOLUTION: The present disclosure provides compounds of Formula I, pharmaceutical salts thereof, and / or solvates of any of them, which present a non-brain penetrant profile. The present disclosure also provides methods for treating gastrointestinal stromal tumors and systemic mastocytosis.SELECTED DRAWING: None
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Citation Information
Patent Citations
A composition useful for treating a disease associated with a KIT
JP2016538257A
Compositions and methods for treating KIT- and PDGFRA-mediated diseases
JP7600140B2
Pyrrolo[1,2-b]pyridazine compounds and compositions useful for treating disorders related to kit and pdgfr
WO2018183712A1