Composition for oral cavity and pouch product for oral cavity

Abstract

To provide a composition for the oral cavity with a high nicotine elution rate and a pouch product for the oral cavity comprising the composition for the oral cavity.SOLUTION: A composition for the oral cavity comprises: a cation exchanger that carries nicotine and has a cation exchange capacity of at least 0.06 mmol / g; and a cation donor.SELECTED DRAWING: Figure 1

Description

[Technical field]

[0001] The present invention relates to oral compositions and oral pouch products. [Background technology]

[0002] Oral pouch products, such as oral tobacco products, are packages in which an oral composition containing a flavor source, etc., is contained in a pouch (packaging material) formed from a material such as nonwoven fabric, and the user places this in the oral cavity to use it. When an oral pouch product is placed in the oral cavity of a user, ingredients such as flavor ingredients in the oral composition seep out to the outside of the packaging material, thereby delivering the flavor ingredients to the user.

[0003] Oral pouch products have been widely developed, and in particular, for oral pouch products containing nicotine, the release of nicotine contained in the stored oral composition is an important function, and therefore technologies for controlling this release are being developed. As a technique for releasing nicotine from an oral composition, for example, Patent Document 1 discloses a technique in which an oral composition contains an ethylene vinyl acetate copolymer, which bonds the vinyl acetate in the polymer with nicotine, thereby slowing down the release of nicotine from the oral composition. Patent Document 2 also discloses a technique in which, in an oral composition containing a cellulose fiber-nicotine mixture in which liquid nicotine is absorbed in the pores of the cellulose fiber, the size, amount, and surface properties of the cellulose fiber, as well as the number, size, and size distribution of the pores of the fiber, can be adjusted to control the release rate of nicotine. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] JP 2019-033751 A [Patent Document 2] Special Publication No. 2016-524916 Summary of the Invention [Problem to be solved by the invention]

[0005] As described above, various technologies for the release of nicotine contained in the oral composition are being developed. Important properties of the oral composition include various properties other than the nicotine release rate in the above-mentioned Patent Documents 1 and 2, and the amount of nicotine eluted from the oral composition is one of them. Usually, when an oral pouch product is placed in the oral cavity, saliva penetrates into the oral composition contained in the product, and the saliva comes into contact with nicotine or a nicotine release source in the oral composition, causing nicotine to elute to the outside. In this technical field, it is desired that the ratio of the amount of nicotine eluted to the nicotine content in the oral composition (elution rate) is high. An object of the present invention is to provide an oral composition having a high nicotine dissolution rate, and an oral pouch product containing the oral composition. [Means for solving the problem]

[0006] As a result of intensive research, the inventors discovered that the above-mentioned problems can be solved by incorporating into an oral composition a cation exchanger having a cation exchange capacity of a certain value or more and capable of supporting nicotine, and a cation donor, and thus arrived at the present invention.

[0007] [1] A cation exchange capacity of 0.06 mmol / g or more that supports nicotine An oral composition comprising an ion exchanger and a cation donor. [2] The oral composition described in [1], wherein the cation exchanger is selected from the group consisting of anionic polymers, ion exchange resins, and combinations thereof. [3] The oral composition described in [2], wherein the cation exchanger is one or more selected from the group consisting of ion exchange resins, pectin, tragacanth gum, gellan gum, xanthan gum and gum arabic. [4] The oral composition according to any one of [1] to [3], wherein the cation in the cation donor is a monovalent or divalent cation. [5] The cation of the cation donor is Na + , N.H. 4 + , K + , Mg 2+ , Ca 2+ , and H + The composition for oral cavity according to [4], wherein the cation of the cation donor is one or more selected from the group consisting of NH 4 + , Mg 2+ , and Ca 2+ The oral composition according to [5], wherein the oral composition is one or more selected from the group consisting of: [7] The oral composition according to any one of [1] to [6], wherein the concentration of the cation donor is 0.025 mol / L or more. [8] The oral composition according to any one of [1] to [7], which has a pH of 2 or more and 9 or less. [9] The cation of the cation donor is H +

[10] The composition for oral cavity according to [4], + The concentration of is 1×10 -5 mol / L or more.

[11] The oral composition described in [9] or

[10] , having a pH of 2.0 or more and 5.0 or less.

[12] The oral composition according to any one of [1] to

[11] , wherein the content of the cation exchanger is 1% by weight or more.

[13] The oral composition described in any of [1] to [9], wherein the cation exchanger is one or more selected from the group consisting of pectin, tragacanth gum, gellan gum, xanthan gum and gum arabic, and the total content of the cation exchangers is 20% by weight or more.

[14] An oral pouch product comprising the oral composition according to any one of [1] to

[13] and a pouch for packaging the composition for oral tobacco products. Effect of the Invention

[0008] According to the present invention, it is possible to provide an oral composition having a high nicotine dissolution rate, and an oral pouch product containing the oral composition. [Brief description of the drawings]

[0009] [Figure 1] 1 is a graph showing the relationship between the type of cation donor and the nicotine dissolution rate. [Diagram 2] 1 is a graph showing the relationship between the type of cation donor and the nicotine dissolution rate. [Diagram 3] 1 is a graph showing a nicotine elution curve when an ion exchange resin is used as a cation exchanger. [Figure 4] 1 is a graph showing a nicotine elution curve when pectin is used as a cation exchanger. [Diagram 5] 1 is a graph showing a nicotine elution curve when pectin is used as a cation exchanger. [Figure 6] 1 is a graph showing a nicotine elution curve when gellan gum is used as a cation exchanger. [Figure 7] 1 is a graph showing a titration curve of a neutralization titration obtained using a cation exchanger. [Figure 8] 1 is a graph showing the nicotine dissolution rate when hydrochloric acid is used as a cation donor. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0010] The following describes in detail the embodiments of the present invention, but these descriptions are merely examples (representative examples) of the embodiments of the present invention, and the present invention is not limited to these contents as long as they do not depart from the gist of the present invention. In this specification, a numerical range expressed using "to" means a range that includes the numerical values ​​before and after "to" as the lower and upper limits, and "A to B" means A or more and B or less. In addition, although a number of embodiments are described in this specification, various conditions in each embodiment may be applied to each other to the extent that they are applicable.

[0011] <Constitution of oral composition> The oral composition according to an embodiment of the present invention (hereinafter also simply referred to as "oral composition") is an oral composition having a cation exchange capacity of 0.06 mmol / g or more and containing a cation exchanger that supports nicotine, and a cation donor. The oral composition has a cation exchanger and a cation donor that support nicotine, and when the cation exchanger has a high cation exchange capacity, it can support a sufficient amount of nicotine. In addition, when the product is used, an ion exchange reaction between the nicotine supported by the cation exchanger and the cation donated by the cation donor containing a cationic species having higher ion selectivity than nicotine is sufficiently carried out, so that a high nicotine dissolution rate can be achieved.

[0012] [Cation exchanger] The cation exchanger contained in the oral cavity composition is not particularly limited as long as it has a cation exchange capacity of 0.06 mmol / g or more and supports nicotine. The type of cation exchanger is not particularly limited, but from the viewpoint of ensuring a sufficient amount of nicotine carried, it is preferably selected from the group consisting of anionic polymers, ion exchange resins, and combinations thereof, and more preferably selected from the group consisting of ion exchange resins, pectin (preferably low methoxy), tragacanth gum, gellan gum (preferably deacylated (LA)), xanthan gum, and gum arabic. In addition, from the viewpoint of nicotine elution efficiency, the cation exchanger is preferably an anionic polymer, particularly a weakly acidic ion exchanger having a carboxyl group as a surface functional group. Specifically, it may be selected from the group consisting of pectin, tragacanth gum, gellan gum, xanthan gum, and gum arabic, and when these anionic polymers are selected, it can have the effect of improving the mouthfeel of the product and improving the consumer's usability. In addition, it may be an ion exchange resin from the viewpoint of carrying a sufficient amount of nicotine per unit weight of the ion exchanger. The type of ion exchange resin is not particularly limited, and examples thereof include polacrilex resin (a resin carrying nicotine is also called "nicotine polacrilex"), Amberlite (registered trademark) IR-20, Amberlite (registered trademark) IRP-69, Amberlite (registered trademark) IRP-58, and Amberlite (registered trademark) IRC-50. From the viewpoint of ensuring a sufficient nicotine dissolution rate and From the standpoint of availability, Amberlite® IPR-64 is preferred.

[0013] Although not particularly limited, for example, a nicotine exchanger can be prepared by adding a certain amount of nicotine solution to a cation exchanger. In addition, the exchange amount of nicotine supported on the cation exchanger per 1 g of the cation exchanger of the prepared nicotine exchanger (nicotine exchange amount per 1 g of cation exchanger) can be evaluated based on the following formula (1). (Amount of nicotine exchanged per 1 g of cation exchanger: g / g) = (Amount of nicotine exchanged per 1 g of cation exchanger: g / g) (ion exchange capacity: mol / g) × (molecular weight of nicotine: 162.23 g / mol) (1) As the nicotine solution, a nicotine solution with a purity of 100% can be used as a solvent. The higher the nicotine exchange amount, the easier it is to control the amount of nicotine contained in the oral composition. The nicotine exchange amount per cigarette is not particularly limited, but is usually 9.7 mg or more, preferably 16 mg or more, more preferably 27 mg or more, and even more preferably 162 mg or more. There is no particular need to set an upper limit, but it is usually 3.25 g or less, and may be 1.62 g or less. The nicotine exchange capacity per gram of cation exchanger can be increased, for example, by increasing the number of pores into which nicotine is physically adsorbed, thereby increasing the specific surface area, and by increasing the number of functional groups capable of electrostatically interacting with nicotine, thereby increasing the number of surface functional groups per specific surface area.

[0014] From the viewpoint of ensuring a sufficient nicotine dissolution rate, the cation exchange capacity (also simply referred to as "ion exchange capacity") of the cation exchanger is not particularly limited as long as it is 0.06 mmol / g or more, but is preferably 0.10 mmol / g or more, more preferably 0.15 mmol / g or more, even more preferably 0.20 mmol / g or more, particularly preferably 1.00 mmol / g or more, even more particularly preferably 5.00 mmol / g or more, and most preferably 8.00 mmol / g or more. In addition, the upper limit does not need to be particularly limited, but is usually 20.00 mmol / g or less, may be 15.00 mmol / g or less, or may be 10.00 mmol / g or less. The cation exchange capacity of a cation exchanger can be increased, for example, by increasing the number of pores into which nicotine is physically adsorbed, thereby increasing the specific surface area, and by increasing the number of functional groups capable of electrostatically interacting with nicotine, thereby increasing the number of surface functional groups per specific surface area. The cation exchange capacity of the cation exchanger will be explained later together with the explanation of the measurement of the equivalence point.

[0015] The cation exchange capacity of a cation exchanger can be measured by the following method. First, the cation exchanger is weighed into a container, 100 mL of ultrapure water is added, and the mixture is heated and dissolved while flowing nitrogen gas. Next, 0.58 g of sodium chloride (NaCl) is added to the solution and dissolved, and the temperature of the solution is adjusted to 37±1°C, and 6 mL of 0.1 mol / L hydrochloric acid is added to obtain solution (A). 0.1 mol / L sodium hydroxide solution is added to the solution (A) and neutralization titration is performed. In this neutralization titration, the cation exchange capacity can be calculated based on the amount of sodium hydroxide solution obtained by subtracting 6 ml from the amount of 0.1 mol / L sodium hydroxide solution added required to neutralize solution (A). This 6 ml is the amount of 0.1 mol / L sodium hydroxide solution required to neutralize 6 ml of 0.1 mol / L hydrochloric acid solution. The weight of the cation exchanger weighed into the container is not particularly limited and may be, for example, 0.1 g. This weight does not affect the weight of the cation exchange capacity finally determined. In the examples described below, the weight is basically evaluated at 0.1 g, but in some experiments, the weight was evaluated at 0.2 g to improve the measurement accuracy.

[0016] The form of nicotine supported on the cation exchanger is not particularly limited. The amount of nicotine per 100 parts by weight of cation exchanger is not particularly limited, but from the viewpoint of ensuring a sufficient nicotine dissolution rate, it is usually 0.5 parts by weight or more, preferably 1 part by weight or more, more preferably 5 parts by weight or more, even more preferably 7.5 parts by weight or more, and is usually 20 parts by weight or less, preferably 15 parts by weight or less, more preferably 12.5 parts by weight or less, even more preferably 10 parts by weight or less. The content of nicotine in the oral composition is not particularly limited, but from the viewpoint of ensuring a sufficient dissolution rate of nicotine, it is usually 0.1% by weight or more, preferably 0.5% by weight or more, more preferably 1% by weight or more, and even more preferably 2% by weight or more, and is usually 10% by weight or less, preferably 7.5% by weight or less, and even more preferably 5% by weight or more. It is more preferable that the nicotine content is 3% by weight or less, and even more preferable that the nicotine content is 3% by weight or less. This nicotine content is the total nicotine content in the oral composition, including not only the nicotine supported on the cation exchanger but also other nicotines, but it can also be applied to the nicotine content supported on the cation exchanger. The amount of nicotine supported on the cation exchanger can be increased, for example, by increasing the number of pores into which nicotine is physically adsorbed, thereby increasing the specific surface area, and by increasing the number of functional groups capable of electrostatically interacting with nicotine, thereby increasing the number of surface functional groups per specific surface area. The state in which nicotine is supported on the cation exchanger means that the surface functional group of the cation exchanger and nicotine interact electrostatically. The amount of nicotine supported on the cation exchanger can also be calculated from the evaluation of the amount of cation exchange described above.

[0017] The content of the cation exchanger in the oral composition is not particularly limited, but from the viewpoint of user preference, it is usually 0.1% by weight or more, preferably 1% by weight or more, more preferably 5% by weight or more, and even more preferably 8% by weight or more, and is usually 50% by weight or less, preferably 30% by weight or less, and even more preferably 20% by weight or less, and may be 15% by weight or less, 12.5% ​​by weight or less, or 10% by weight or less. Furthermore, when the cation exchanger in the oral composition is an ion exchange resin, the content of the cation exchanger in the oral composition is preferably 0.1 wt % or more, more preferably 1 wt % or more, and even more preferably 5 wt % or more, and is preferably 15 wt % or less, more preferably 12.5 wt % or less, and even more preferably 10 wt % or less. Furthermore, when the cation exchanger in the oral composition is selected from the group consisting of pectin, tragacanth gum, gellan gum, xanthan gum and gum arabic, the content of the cation exchanger in the oral composition is preferably 10% by weight or more, more preferably 15% by weight or more, and even more preferably 20% by weight or more, and is preferably 50% by weight or less, more preferably 30% by weight or less, and even more preferably 20% by weight or less. The measurement method for the amounts of content, concentration, etc. specified in this specification is described in the explanation of each item, but it may also be calculated from the amount of raw materials charged when producing the oral composition or oral pouch product.

[0018] [Cation donor] The cation donor is not particularly limited as long as it is a substance capable of donating a cation, and examples thereof include salts consisting of a cation and an anion, specifically, sodium chloride, calcium lactate, sodium dihydrogen phosphate, magnesium chloride, etc., and it is preferable that the cation donor is a component permitted to be added to products as a food additive listed in Appendix 1 of the Enforcement Regulations of the Food Sanitation Act. + When a cation donor having the formula: is used, an inorganic acid or an organic acid described later can be used as the cation donor. The type of cation in the cation donor is not particularly limited, but from the viewpoint of ensuring a sufficient dissolution rate of nicotine, it is preferably a monovalent or divalent cation, and the monovalent cation may be an alkali metal, and the divalent cation may be an alkaline earth metal. In addition, from the viewpoint of ensuring a sufficient dissolution rate of nicotine, the monovalent or divalent cation is preferably Na cation, which has a higher ion selectivity than nicotine. + , N.H. 4 + , K + , Mg 2+ , Ca 2+ , and H + and preferably selected from the group consisting of NH 4 + , Mg 2+ , and Ca 2+ or, and H + More preferably, Mg 2+ and Ca 2+ or, and H + It is even more preferable that: The anion species serving as a counter ion of the cation in the cation donor is not particularly limited, and may be, for example, For example, preferred examples of inorganic acids include hydrochloric acid, carbonic acid, and phosphoric acid.Preferred examples of organic acids include malic acid, citric acid, succinic acid, levulinic acid, pyruvic acid, tartaric acid, adipic acid, lactic acid, butyric acid, acetic acid, formic acid, benzoic acid, and L-ascorbic acid.From the viewpoint of ensuring a sufficient nicotine dissolution rate and improving the smoking taste, carbonic acid or phosphoric acid is more preferred. Whether or not a target substance can be a cation donor depends on the pH of the oral composition: for example, phosphoric acid is a cation donor when the pH of the oral composition is less than 7, but is not a cation donor when the pH is 7 or higher. In this embodiment, the pH can be set according to the preference of the user of the oral composition, and the type of cation donor can be selected accordingly.

[0019] The concentration of the cation donor (or the concentration of the cation) in the oral cavity composition is not particularly limited. However, from the viewpoint of ensuring a sufficient dissolution rate of nicotine, it is preferably 1×10 -5 mol / L or more, and 1×10 -3 mol / L or more is preferable, and 1×10 -2 mol / L or more, more preferably 0.025 mol / L or more, and particularly preferably 2 mol / L or more, and preferably 1 mol / L or less, and more preferably 1×10 -1 It is more preferable that the concentration is 100 mol / L or less. The oral composition is H + In the case where the oral composition contains a cation donor having a cation other than + The concentration of cation donors with cations other than + (the concentration of the cation other than 1×10 may be used) is not particularly limited, but from the viewpoint of ensuring a sufficient dissolution rate of nicotine, it is usually 1×10 -3 mol / L or more, 1×10 -2 mol / L or more, and usually 2 mol / L or less, preferably 1 mol / L or less, and more preferably 1×10 -1 It is more preferable that the concentration is 100 mol / L or less. The oral composition is H + In the case where the oral composition contains a cation donor having the formula + The concentration of the cation donor (or H + (concentration may be 1×10 or less) is not particularly limited, but from the viewpoint of ensuring a sufficient dissolution rate of nicotine, -5 mol / L or more, and 1×10 -4mol / L or more is preferable, and 1×10 -3 mol / L or more is more preferable, and usually 1×10 -1 mol / L or less, 1×10 -2 It may be mol / L or less. The method for qualitatively and quantitatively determining the cationic species contained in the oral composition is not particularly limited, and may be, for example, measured by ion chromatography.

[0020] [Other substances] The oral cavity composition may contain substances (other substances) other than the above-mentioned cation exchanger, nicotine, and cation donor, such as a base material, tobacco material, humectant, pH adjuster, gelling agent, gelling auxiliary component, water, flavoring, sweetener, bitterness suppressant, whitening agent, emulsifier, etc. Furthermore, nicotine may or may not be contained in a form other than the nicotine supported by the above-mentioned cation exchanger. The content of other substances in the oral composition is not particularly limited, and for substances for which no preferred content is specified, the composition can be adjusted appropriately according to the product design.

[0021] The type of the substrate is not particularly limited, and examples thereof include cellulose, microcrystalline cellulose (MCC), spherical cellulose, porous cellulose, etc., and it is preferable to include at least one selected from these groups, and from the viewpoint of the degree of freedom in adjusting the bulk density of the composition and the improvement of the appearance quality by exhibiting whiteness, cellulose or microcrystalline cellulose is more preferable. These substances may be used alone or in combination of two or more types in any type and ratio. The content of the base material in the oral composition is not particularly limited, but from the viewpoint of product stability, it is usually 50% by weight or more, preferably 53% by weight or more, and more preferably 55% by weight or more, and it is usually 70% by weight or less, preferably 68% by weight or less, and more preferably 65% ​​by weight or less.

[0022] The oral composition may or may not contain tobacco material (even if it is below the detection limit). The form of the tobacco material is not particularly limited, and may be, for example, only a material derived from tobacco leaves such as the lamina, stems, or roots of tobacco leaves (hereinafter also referred to as raw tobacco), or may be a combination of the raw tobacco with other components. The tobacco material may be processed products such as tobacco shreds, tobacco sheets, tobacco granules, or tobacco extract. The type of tobacco leaf is not particularly limited, and may be, for example, flue, burley, or orient, native, other Nicotiana tabacum species, Nicotiana rustica species, or a mixture thereof. The mixture may be a suitable blend of the above species to achieve the desired flavor. Details of the tobacco species are disclosed in "Encyclopedia of Tobacco, Tobacco Research Center, March 31, 2009". The content of tobacco material in the oral composition is not particularly limited, and may be, for example, 0.01% by weight or more and 10% by weight or less, 0.05% by weight or more and 5% by weight or less, or 0.1% by weight or more and 1% by weight or less.

[0023] The type of moisturizer is not particularly limited, and examples thereof include glycerin, propylene glycol, etc., and it is preferable to include at least one selected from these groups, and from the viewpoint of product storage stability, glycerin is preferable. These substances may be used alone or in any combination of two or more types in any type and ratio. The content of the moisturizer in the oral composition is not particularly limited, but from the viewpoint of product stability, it is usually 1 wt % or more, preferably 3 wt % or more, more preferably 5 wt % or more, and even more preferably 8 wt % or more, and is usually 30 wt % or less, preferably 25 wt % or less, more preferably 20 wt % or less, and even more preferably 15 wt % or less.

[0024] The oral composition may contain a pH adjuster other than the above-mentioned phosphates, such as sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate, sodium citrate, etc., but in order to suppress self-heating as described above in the description of the nicotine-carrying resin and humectant, it is preferable that the composition does not contain carbonates (that is, that the amount is substantially below the detection limit).

[0025] The oral composition may contain water, and the content of water in the oral composition (moisture content) is usually 4% by weight or more. If the moisture content is less than 15% by weight, the oral composition is likely to have a rough texture, and the oral composition is difficult to manufacture. In addition, in order to ensure good fluidity and adhesion of the oral composition and to facilitate the manufacture of the oral composition, it is effective to add a humectant. As a method for solving the same problem, it is effective to increase the water content of the composition. In this case, the water content is preferably 30% by weight or more, more preferably 45% by weight or more, and is usually 55% by weight or less, and preferably 50% by weight or less. The moisture content can be adjusted by adjusting the amount of water added or by carrying out a heating treatment or drying treatment during the manufacturing stage. The water content of the oral composition can be measured using a heat-dry moisture meter (e.g., HB 43-S manufactured by METTER TOLEDO). When measuring, the sample is placed in a specified container and heated to a temperature of 100° C. The measurement is terminated when the change in weight is 1 mg or less in 60 seconds, and the moisture content is calculated from the weighing values ​​before and after heating.

[0026] The type of flavor is not particularly limited, and examples thereof include menthol, tobacco leaf extract, natural plant flavors (e.g., cinnamon, sage, herbs, chamomile, kudzu, sweet tea, cloves, lavender, cardamom, cloves, nutmeg, bergamot, geranium, honey essence, rose oil, lemon, orange, cinnamon bark, caraway, jasmine, ginger, and korea). , vanilla extract, spearmint, peppermint, cassia, coffee, celery, cascarilla, sandalwood, cocoa, ylang-ylang, fennel, anise, licorice, St. John's bread, plum extract, peach extract, etc.), sugars (e.g., glucose, fructose, isomerized sugar, caramel, honey, molasses, etc.), cocoa powders (powder, extracts, etc.), esters (e.g., isoamyl acetate, linalyl acetate, isoamyl propionate, linalyl butyrate, etc.), ketamine, ... Examples of the aromatic compounds include tones (e.g., menthone, ionone, damascenone, ethyl maltol, etc.), alcohols (e.g., geraniol, linalool, anethole, eugenol, etc.), aldehydes (e.g., vanillin, benzaldehyde, anisaldehyde, etc.), lactones (e.g., γ-undecalactone, γ-nonalactone, etc.), animal fragrances (e.g., musk, ambergris, civet, castoreum, etc.), and hydrocarbons (e.g., limonene, pinene, etc.). These substances may be used alone or in any combination of two or more kinds and in any ratio.

[0027] The type of sweetener is not particularly limited, and examples thereof include sugar alcohols such as xylitol, maltitol, erythritol, and sweeteners such as acesulfame potassium, sucralose, and aspartame, and sugar alcohols are preferred from the viewpoint of taste adjustment. These substances may be used alone or in combination of two or more types in any type and ratio.

[0028] The type of bitterness suppressant is not particularly limited, and may be, for example, soybean lecithin. Soybean lecithin is a phospholipid, and may be phosphatidylcholine, phosphatidylethanolamine, or phosphatidic acid. These substances may be used alone or in any combination of two or more types in any type and ratio.

[0029] The type of whitening agent is not particularly limited, and examples thereof include fine silicon dioxide, titanium dioxide, calcium carbonate, etc., and from the viewpoint of the effect on the taste of the product, fine silicon dioxide is preferred. These substances may be used alone or in any combination of two or more types in any type and ratio.

[0030] The type of emulsifier is not particularly limited, and may be, for example, an emulsifier added to food. The emulsifier may be one or more selected from the group consisting of sucrose fatty acid ester, organic acid glycerin fatty acid ester, polyglycerin fatty acid ester, and lecithin. The sucrose fatty acid ester may be sucrose palmitate ester and sucrose stearate ester. The organic acid glycerin fatty acid ester may be glycerin succinate fatty acid ester and glycerin diacetyltartarate fatty acid ester. The polyglycerin fatty acid ester may be decaglycerin fatty acid ester. The content of the emulsifier in the oral cavity composition is usually 1% by weight or more and 20% by weight or less, and preferably 5% by weight or more and 15% by weight or less.

[0031] The content of each of the above components can be measured by a known method.

[0032] <Characteristics of oral compositions> [pH of oral composition] The pH of the oral composition at a measurement temperature of 25°C is not particularly limited, but from the viewpoint of the effect on the taste of the product, it is usually 2.0 or more, preferably 5.0 or more, more preferably 7.0 or more, and usually 10.0 or less, preferably 9.5 or less, more preferably 9.0 or less. The pH can be adjusted by controlling the amount of pH adjuster added. Note that the pH values ​​in this specification, including the above pH values, are values ​​measured at a measurement temperature of 25°C. The cation in the cation donor is H +When the cation is other than the above, the pH of the oral composition at a measurement temperature of 25°C is not particularly limited, but from the viewpoint of the effect on the taste of the product, it is usually 6 or more, preferably 6.5 or more, and more preferably 7.0 or more, and is usually 10.0 or less, preferably 9.5 or less, and more preferably 9.0 or less. The cation in the cation donor is H + In this case, the pH of the oral composition at a measurement temperature of 25°C is not particularly limited, but from the viewpoint of the effect on the taste of the product, it is usually 2.0 or more, preferably 3.0 or more, and more preferably 3.5 or more, and is usually 5.0 or less, preferably 4.5 or less, and more preferably 4.0 or less.

[0033] The pH of the oral composition at the measurement temperature of 25°C can be measured using a pH analyzer (e.g., HORIBA, Ltd.'s LAQUA F-72 flat ISFET pH electrode) by adding 20 ml of water to 2 g of the oral composition, shaking for 10 minutes, and measuring the supernatant. The calibration of the equipment is performed by three-point calibration using, for example, a phthalic acid pH standard solution (pH 4.01), a neutral phosphate pH standard solution (pH 6.86), and a borate pH standard solution (pH 9.18) (all from Wako Pure Chemical Industries).

[0034] [Particle size of components of oral composition when dry] The oral composition is preferably composed of a plurality of solid granules, and the size of the granules is not particularly limited. For example, it is preferable that the dried oral composition components satisfy the following classification conditions. The dried oral composition is preferably classified using a sieve having the following mesh size. From the viewpoints of the user's mouth feel during use, ease of handling during production, and control of quality variation, the composition usually passes through a sieve having 15 mm mesh size (<15 mm), preferably passes through a sieve having 10 mm mesh size (<10 mm), more preferably passes through a sieve having 5 mm mesh size (<5 mm), and even more preferably passes through a sieve having 3.2 mm mesh size (<3.2 mm). For example, when all of the dried oral composition passes through a sieve having 3.2 mm mesh size, this indicates that the maximum particle size of the oral composition when dried is 3.2 mm or less. There is no need to set a lower limit for the particle size of the components of the oral composition when dry, but from the viewpoint of preventing leakage from the pouch, it is usually 3 μm or more. The above-mentioned dried oral composition can be obtained by drying the oral composition by keeping it at 70° C. to 80° C. for about 3 hours. The maximum particle size of the oral composition can be appropriately increased / decreased by adjusting the particle size of solid components such as the base material or nicotine-loaded ion exchange resin, and their moisture contents.

[0035] [Elution rate] Although there are no particular limitations on the dissolution rate of nicotine from the oral composition, a higher dissolution rate is preferable, whereas from the viewpoint of user preference, it may be 99% or less, or may be 90% or less. The amount of nicotine dissolved from each pouch product was measured using a dissolution tester, BIO-DIS Reciprocating Cylinder Apparatus (compliant with USP Apparatus 3) manufactured by Agilent. was used. The test conditions were a temperature of 37°C and a dip speed of 6 DPM (Dip Per Minute). The time was 15 minutes, and the moving distance was 10 cm. Eight pouches were set in one inner tube. The test liquid was 240 mL of the artificial saliva described above. The sampling times for the eluate were 0.1 minutes, 2 minutes, 5 minutes, 7.5 minutes, 10 minutes, 20 minutes, 40 minutes, and 60 minutes. Solution test system When the oral composition is an aqueous solution, the amount of solution (30 mL) that is assumed to be the amount of elution per product in the elution test of the pouch product is treated as level 1. For example, the desired ingredients are added to 30 mL of pure water to prepare a sample for measuring the amount of nicotine elution. After the dissolution test, or after the liquid oral composition has been prepared, it is filtered through an ADVANTEC CELLULOSE ACETATE, NON-STERILE 0.45 μm filter (Toyo Roshi Kaisha, Ltd.) and subjected to reverse-phase high performance liquid chromatography. The value (A) thus obtained can be used to evaluate the dissolution rate of nicotine.

[0036] The protocol for reversed-phase high performance liquid chromatography is shown below. ·Equipment: Agilent 1200 series Mobile phase: Gradient analysis of 95% ammonium acetate aqueous solution (pH 10) and 95% acetonitrile aqueous solution Column: Acquit BEH C18 column (Waters) ·Flow rate 0.5ml / min Detection wavelength: 254 nm (reference wavelength: 455 nm) The elution rate is calculated from the formula {(A) / (B)}×100 using the value (A) (corresponding to the amount of nicotine in the eluate) determined by the above reverse high performance liquid chromatography and the value (B) indicating the amount of nicotine supported on the cation exchanger in the composition.

[0037] <Method of manufacturing oral composition> The method for producing the above-mentioned oral composition is not particularly limited, and it can be produced by a known method or a combination of known methods. An example of the method for producing the oral composition is shown below. Each of the raw materials shown below can be the same as the raw materials described above. First, a nicotine-supported cation exchanger, a cation donor, and, if necessary, an optional component such as a base material are mixed in a mixer to obtain a mixture (mixing step). Next, optional ingredients such as a flavoring and a moisturizing agent are added, and the mixture is further stirred and mixed to obtain a composition for the oral cavity (stirring step). Another embodiment of the present invention is a method for producing an oral composition, which includes a mixing step of mixing at least a nicotine-loaded cation exchanger and a cation donor to obtain a mixture.

[0038] The mixture before heating may be subjected to a treatment of adding water and / or heating, if necessary. After preparing the mixture, the mixture may be dried (drying step). Then, the mixture may be cooled. Cooling may be performed naturally or by using some cooling means (cooling step). By drying, the water content of the mixture can be adjusted to a desired value between 5% by weight and 55% by weight. This makes it easier to adjust the water content of the oral composition as the target product.

[0039] An aqueous solution containing a pH adjuster may be further added to the mixture obtained in the above step (or the drying step or cooling step) to adjust the pH at a measurement temperature of 25°C to preferably 7 to 10, more preferably 7.5 to 9.5, and even more preferably 8 to 9. Furthermore, a sweetener such as acesulfame potassium, a flavoring such as menthol, and / or a bitterness suppressant such as soybean lecithin, and a moisturizing agent such as glycerin are appropriately added (additive addition step) to obtain the desired oral composition. When the additives are added, they may be added in the form of a solid or an aqueous solution in which they are dissolved in water. When they are added in the form of an aqueous solution, they may be added after being dissolved in a predetermined amount of water so as to achieve the final moisture content of the pouch product.

[0040] The method for loading nicotine onto the cation exchanger is not particularly limited, and can be carried out using a known method. For example, when an ion exchange resin is used, nicotine can be loaded onto the cation exchanger by immersing it in a nicotine solution. Also, when an anionic polymer is used, nicotine can be loaded onto the cation exchanger by mixing a predetermined nicotine solution with a solution of the ion exchanger sufficiently dissolved in a solvent.

[0041] <Uses of oral compositions> The use of the oral composition is not particularly limited, and for example, it can be used in oral pouch products described below, and can also be used in other known oral product forms such as dissolving tablets, gels, pastes, chewing gums, lozenges, or hard candies.

[0042] <Oral pouch product composition> Another embodiment of the present invention, an oral pouch product (hereinafter also simply referred to as "oral pouch product"), is an oral pouch product having the above-mentioned oral composition and a pouch in which the composition for oral tobacco products is packaged. The pouch (packaging material) is not particularly limited as long as it can package the oral composition described above, and it is preferable that it is insoluble in water and has permeability to liquids (water, saliva, etc.) and water-soluble components in the oral composition, and known materials can be used. Examples of the pouch material include cellulose-based nonwoven fabrics, and commercially available nonwoven fabrics may also be used. A sheet made of such a material is formed into a bag shape, the oral composition is poured into it, and the pouch product can be produced by sealing it by means of heat sealing or the like. The basis weight of the above-mentioned sheet is not particularly limited, but is usually from 12 gsm to 54 gsm, and preferably from 24 gsm to 30 gsm. The thickness of the above-mentioned sheet is not particularly limited, and is usually 100 μm or more and 300 μm or less, and preferably 175 μm or more and 215 μm or less.

[0043] A water-repellent material may be partially applied to at least one of the inner and outer surfaces of the pouch. A water-repellent fluororesin is suitable as the water-repellent material. Specifically, an example of this type of water-repellent fluororesin is Asahi Guard (registered trademark) manufactured by Asahi Glass Co., Ltd. The water-repellent fluororesin is applied to packaging materials for foods and products containing fats and oils, such as confectionery, dairy products, side dishes, fast food, or pet food. Therefore, this type of water-repellent fluororesin is safe to be applied to a pouch placed in the oral cavity. The water-repellent material is not limited to fluororesin, and may be, for example, paraffin resin, silicone resin, epoxy resin, or other resins that have a water-repellent effect.

[0044] The pouch may contain any ingredient, such as a raw material for adjusting the scent or taste, a flavoring, an additive, a tobacco extract, a coloring, etc. The manner in which these ingredients are contained is not particularly limited, and examples of the ingredients include coating the pouch surface, impregnating the pouch, and, in the case of a pouch made of fibers, containing the ingredients in the fibers. Furthermore, the appearance of the pouch is not particularly limited, and may be not only non-transparent but also translucent or transparent, in which case the oral composition packaged in the pouch can be seen through.

[0045] The size and weight of the oral pouch product are not particularly limited, and the size of the pouch product before use may be 25 mm (28 mm, 35 mm, 38 mm) or more and 40 mm or less in length, or 28 mm or more and 38 mm or less in length, and 10 mm or more and 20 mm or less in length, or 14 mm or more and 18 mm or less in length. In addition, the weight of the oral pouch product before use may be 0.1 g or more and 2.0 g or less, or 0.3 g or more and 1.0 g or less. The weight ratio of the oral composition to the total weight of the oral pouch product is not particularly limited, but , usually 80% by weight or more, preferably 85% by weight or more, and more preferably 90% by weight or more, and usually 99% by weight or less, preferably 97% by weight or less, and more preferably 95% by weight or less.

[0046] <Manufacturing method of oral pouch products> Another embodiment of the present invention, a method for producing an oral pouch product (also simply referred to as a "method for producing an oral pouch product" or "production method"), is a method for producing an oral pouch product, which includes an oral composition production step of producing an oral composition having a cation exchange capacity of at least 0.06 mmol / g or more and containing a cation exchanger that supports nicotine and a cation donor.

[0047] [Oral composition manufacturing process] The oral composition production process is not particularly limited, and can be, for example, a process of carrying out the above-mentioned oral composition production method.

[0048] [Packaging process] The oral composition obtained in the oral composition preparation step is packaged with a packaging agent to obtain a pouch product (packaging step). The packaging method is not particularly limited, and a known method can be applied. For example, a known method can be used, such as a method in which the oral composition is placed in a bag-shaped nonwoven fabric and then sealed. In the packaging step, after the oral composition is put into the packaging agent and the packaging agent is sealed, water may be further added to obtain an oral composition having a desired water content (water adding step). For example, when the water content of the target oral composition is 50% by weight and the water content of the oral composition obtained in the oral composition preparation step is 15% by weight, the remaining 35% by weight of water is added.

[0049] <Applications of oral pouch products> The uses (modes of use) of oral pouch products are not particularly limited, but examples include oral tobacco such as chewing tobacco, snuff, and compressed tobacco, and nicotine-containing preparations called nicotine pouches, etc. These are inserted between the lips and gums in the oral cavity to enjoy the taste and aroma.

[0050] In the measurement of each characteristic in this specification, unless otherwise specified, the measurement sample is kept in an environment similar to the measurement environment for 48 hours or more before the measurement. In addition, the measurement temperature, measurement humidity, and measurement pressure are normal temperature (22±2°C), normal humidity (60±5% RH), and normal pressure (atmospheric pressure) unless otherwise specified. EXAMPLES

[0051] The present invention will be described in more detail below with reference to examples, but the present invention should not be construed as being limited to the following examples.

[0052] <Experiment 1> [Preparation of oral composition] Example 1 For 30 mL of ultrapure water, add nicotine ion exchange resin (20% Nicotine Polacrilex manufactured by Contraf nicotex) at a concentration of 1.0 mg / mL and NaH 2 PO 4 (Univar BV Monosodium phosphate anhydrous, FG (MSP A FG) manufactured by The mixture was stirred at 200 rpm for 60 minutes to obtain an oral composition. 2 PO 4 The content of NaH is 0.3% by weight. 2 PO 4 Cation (Na + The content of ) was 0.025 mol / L. The pH at was 5.4. The content of the nicotine exchange resin, which is an ion exchanger, in the oral composition was about 0.1% by weight. Since the oral composition does not contain any nicotine other than that derived from nicotine polacrilex, the content of nicotine in the oral composition was found to be about 0.02% by weight. The ion exchange capacity of the above nicotine ion exchange resin (Nicotine Polacrilex 20% manufactured by Contraf Nicotex) and the amount of nicotine exchanged per 1 g of cation exchanger were evaluated using the method described below, and the ion exchange capacity was found to be 8.27 mmol / g and the amount of nicotine exchanged was found to be 1.341 g.

[0053] Example 2 Under similar cation concentration conditions, NaH 2 PO 4 An oral composition was prepared in the same manner as in Example 1, except that NaCl (Sodium Chloride, manufactured by Sigma-Aldrich) was used instead of Monosodium phosphate anhydrous, FG (MSP A FG), manufactured by Univar BV. The content of NaCl in the oral composition was 0.15% by weight, and the cation (Na + ) was 0.025 mol / L. The oral composition had a pH of 6.2 at 25°C.

[0054] Example 3 Under similar cation concentration conditions, NaH 2 PO 4 An oral composition was prepared in the same manner as in Example 1, except that the oral composition (Monosodium phosphate anhydrous, FG (MSP A FG) manufactured by Univar BV) was replaced with KCl (potassium chloride manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.). The content of KCl in the oral composition was 0.18% by weight, and the cation (K + The content of ) was 0.025 mol / L. The pH of the oral composition at 25°C was 6.4.

[0055] Example 4 Under similar cation concentration conditions, NaH 2 PO 4 (Monosodium phosphate anhydrous, FG (MSP A FG) manufactured by Univar BV) was dissolved in NH 4An oral composition was prepared in the same manner as in Example 1, except that NH 2 in the oral composition was changed to NH 2 Cl (ammonium chloride manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.). 4 The Cl content was 0.13 wt% and NH 4 Cl cation (NH 4 + ) was 0.025 mol / L. The oral composition had a pH of 5.9 at 25°C.

[0056] Example 5 Under similar cation concentration conditions, NaH 2 PO 4 Monosodium phosphate anhydrous, FG (MSP A FG) manufactured by Univar BV was used as calcium lactate ((CH 3 C(OH)COO) 2 The oral composition was prepared in the same manner as in Example 1, except that the calcium lactate content in the oral composition was 0.54% by weight, and the cation (Ca 2+ ) was 0.025 mol / L. The oral composition had a pH of 5.1 at 25°C.

[0057] Example 6 Under similar cation concentration conditions, NaH 2 PO 4 (Monosodium phosphate anhydrous, FG (MSP A FG) manufactured by Univar BV) was added to CaCl 2 An oral composition was prepared in the same manner as in Example 1, except that the calcium chloride in the oral composition was changed to calcium chloride manufactured by Fujifilm Wako Pure Chemical Industries, Ltd. 2 The content of CaCl is 0.28% by weight. 2 cation (Ca 2+ The content of ) was 0.025 mol / L. The pH of the oral composition at 25°C was 4.6.

[0058] Example 7 Under similar cation concentration conditions, NaH 2 PO 4 (Monosodium phosphate anhydrous, FG (MSP A FG) manufactured by Univar BV) was added to MgCl 2 The oral composition was prepared in the same manner as in Example 1, except that the MgCl in the oral composition was changed to magnesium chloride (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.). 2 The content of MgCl is 0.24% by weight. 2 cations (Mg 2+ ) was 0.025 mol / L. The oral composition had a pH of 4.8 at 25°C.

[0059] Comparative Example 1 NaH 2 PO 4 An oral composition was prepared in the same manner as in Example 1, except that no monosodium phosphate anhydrous, FG (MSP A FG) manufactured by Univar BV was added. The pH of the oral composition at 25°C was 8.4.

[0060] [Ion exchange capacity] The equivalence point and ion exchange capacity of the cation exchanger were evaluated by the following method. First, the cation exchanger (0.1 g for gum arabic and 0.2 g for gum arabic) was weighed into a container, 100 mL of ultrapure water was added, and the mixture was heated and dissolved while flowing nitrogen gas. Next, 0.58 g of sodium chloride (NaCl) was added to dissolve the cation exchanger to obtain a solution, after which the temperature of the solution was adjusted to 37±1°C, 6 mL of 0.1 mol / L hydrochloric acid was added, and the solution was titrated with 0.1 mol / L sodium hydroxide solution. From the obtained titration curve of the neutralization titration, the inflection point of the titration curve was calculated to obtain the equivalence point. Next, the ion exchange capacity was calculated from the titration amount of the sodium hydroxide solution obtained by subtracting 6 mL of 0.1 mol / L sodium hydroxide solution, which is the amount of 0.1 mol / L sodium hydroxide solution required to neutralize 6 mL of 0.1 mol / L hydrochloric acid.

[0061] [Nicotine exchange amount] The nicotine exchange amount per gram of cation exchanger in the composition was calculated using the ion exchange capacity determined by the above evaluation and the following formula (1). (nicotine exchange amount per 1 g of cation exchanger in the composition: g / g) = (cation exchange amount in the composition Ion exchange capacity per gram of ion exchanger: mol / g) x (molecular weight of nicotine: 162. 23g / mol) (1)

[0062] [Elution rate] The above nicotine composition was filtered through an ADVANTEC CELLULOSE ACETATE, NON-STERILE 0.45 μm filter (Toyo Roshi Kaisha, Ltd.) and subjected to reversed-phase high performance liquid chromatography to quantify the amount of nicotine eluted.

[0063] The protocol for reversed-phase high performance liquid chromatography is shown below. ·Equipment: Agilent 1200 series Mobile phase: Gradient analysis of 95% ammonium acetate aqueous solution (pH 10 at 25°C) and 95% acetonitrile aqueous solution Column: Acquit BEH C18 column (Waters) ·Flow rate 0.5ml / min Detection wavelength: 254 nm (reference wavelength: 455 nm)

[0064] The dissolution rate was calculated using the following formula: The evaluation results are shown in Table 1 and Figure 1. (Dissolution rate) = (Value quantified by the above reversed-phase high-performance liquid chromatography) x 100 / (Nicotine exchange amount per gram of cation exchanger in the composition)

[0065] [Table 1]

[0066] Of the above oral compositions, NaOH was added to the oral compositions of Examples 2 to 4 and 6 to 7 to achieve the pH shown in Table 2, and the nicotine dissolution rate was evaluated in the same manner as above. The evaluation results are shown in Table 2 and Figure 2.

[0067] [Table 2]

[0068] From Table 1 and FIG. 1, it can be seen that when the pH of the oral composition is less than 8.4, the nicotine dissolution rate by cation exchange (hereinafter also simply referred to as "nicotine dissolution rate") exceeds 50% in the oral composition containing a cation donor, whereas the nicotine dissolution rate is less than 10% in the oral composition not containing a cation donor. In addition, from Tables 1 to 2 and Figures 1 to 2, the nicotine dissolution rate was + , K + <NH 4 + <Mg 2+ , Ca 2+ The inventors speculate on this tendency as follows. The cation retention capacity of cation exchangers such as weak cation ion exchange resins (polacrilex) varies depending on the type of ion due to electrostatic interactions (Coulomb forces). The index of the strength of adsorption is called selectivity, and the larger the valence of the ion (divalent ions are more strongly adsorbed than monovalent ions), the larger the period (larger the atomic radius) of the ion if they are in the same group of the periodic table. The smaller the period, the greater the selectivity. The size of the period is as follows: Li + <Na + <NH 4 + <Mg 2+ <Ca 2+ <H + When multiple ions coexist, the more selective cations are retained in the ion exchange resin, while the less selective cations are eluted. This is thought to be why the above results for the nicotine elution rate were obtained. In this experiment, protons (H + The inventors speculate that the effect is small because the molar concentration of ) is more than 1 / 1000th lower than the concentration of the cations in the above cation donors.

[0069] <Experiment 2> The ingredients were mixed according to Table 3, and the ingredients were mixed while stirring to prepare an oral composition. The composition was applied to nonwoven fabrics (BFF technical fabrics) at 0.65 g / piece. Company-made, basis weight 27.0g / m 2 ) and then sealed with heat seal to produce a pouch product. Nicotine Polacrilex 20% manufactured by Contraf nicotex was used as the nicotine ion exchange resin in this experiment. The compositions of Examples 1 and 2 were prepared so that the pH was 8.5.

[0070] [Table 3]

[0071] The amount of nicotine dissolved from each oral pouch product was measured using a dissolution tester, BIO-DIS Reciprocating Cylinder Apparatus (compliant with USP Apparatus 3) manufactured by Agilent, to evaluate the dissolution rate. The test conditions were a temperature of 37°C and a dip speed of 6 DPM (Dip Per Minute). The time was 15 minutes, and the moving distance was 10 cm. Eight pouches were set in one inner tube. The test liquid was 240 mL of the artificial saliva described above. The sampling time of the elution liquid was 0.1 minutes, 2 minutes, 5 minutes, 7.5 minutes, 10 minutes, 20 minutes, 40 minutes and 60 minutes. The results are shown in Figure 3. The nicotine elution rates of Examples 8 and 9 were 96.25% and 94.18%, respectively.

[0072] The above artificial saliva was prepared in the following manner. (1) Prepare 1,000 mL of distilled water. (2) Add 2 mL of concentrated sulfuric acid to lower the pH to below 2.5. (3) Measure out the specified amounts of the following reagents and dissolve them in the above solution. K 2 HPO 4 H 2 O 0.68g NaCl (anhydrous) 0.33g CaCl 2 2H 2 O 0.15g KCl (anhydrous) 0.75g K 2 CO 3 (Anhydrous) 0.53g MgCl 2 6H 2 O 0.17g (4) Adjust the pH of the solution (25°C) to 6.8 ± 0.1 using 5N NaOH.

[0073] As can be seen from FIG. 3, the amount of ammonia compounds was only 0.7% by weight (NH 4 + It was found that the addition of just 0.2% by weight of nicotine increased the amount of nicotine dissolved from the start of dissolution and improved the dissolution rate. This shows that the improvement in dissolution rate due to ion selectivity is accompanied by an increase in the dissolution rate, which leads to an improvement in the onset of stimulation.

[0074] Next, the raw materials were blended according to Table 4 and mixed to prepare each oral composition. Each oral composition was applied to a nonwoven fabric (manufactured by BFF technical fabrics, basis weight 27.0 g) at 0.65 g / piece. g / m 2 ) and then heat sealed to produce each oral pouch product.

[0075] The properties of each oral pouch product are summarized in Table 4. The pectin and gellan gum shown in Table 4 are the same as those used in Experiment 3 described below. The amount of nicotine released from these oral pouch products was evaluated in the same manner as in Experiment 1. The results are shown in Figures 4 to 6.

[0076] [Table 4]

[0077] As can be seen from Figures 4 to 6, by using pectin or gellan gum as the cation exchanger and a Mg-containing substance as the cation donor, it is possible to provide a product that provides sufficient flavor components within the time period in which the product is used and does not impair the user's preferences, especially when the product is held in the mouth for 30 minutes or more.

[0078] <Experiment 3> The following materials were used as cation exchangers, and the equivalence point, ion exchange capacity, and nicotine exchange amount per gram of cation exchanger were evaluated. The evaluation results are shown in Table 5. Polarix resin: The following materials are anionic polymers. Pectin (low methoxy) Gum tragacanth Gellan gum (deacylated (LA)) Xanthan gum Gum arabic ·Sodium alginate ·Carrageenan (ι-carrageenan)

[0079] [Ion exchange capacity] The equivalence point and ion exchange capacity of the cation exchanger were evaluated by the following method. First, the cation exchanger (0.1 g for gum arabic and 0.2 g for gum arabic) was weighed into a container, 100 mL of ultrapure water was added, and the mixture was heated and dissolved while flowing nitrogen gas. Next, 0.58 g of sodium chloride (NaCl) was added to dissolve the cation exchanger to obtain a solution, after which the temperature of the solution was adjusted to 37±1°C, 6 mL of 0.1 mol / L hydrochloric acid was added, and the solution was titrated with 0.1 mol / L sodium hydroxide solution. The titration curve of the obtained neutralization titration is shown in Figure 7. The lower figure in Figure 7 is an enlarged view of the area indicated by the dashed line in the upper figure in Figure 7. From this titration curve, the inflection point of the titration curve was calculated to obtain the equivalence point. Next, the ion exchange capacity was calculated from the titration amount of sodium hydroxide solution obtained by subtracting 6 ml of 0.1 mol / L sodium hydroxide solution required to neutralize 6 mL of 0.1 mol / L hydrochloric acid.

[0080] [Nicotine exchange amount] The nicotine exchange amount per gram of cation exchanger was calculated using the ion exchange capacity determined by the above evaluation committee and the following formula (1). (Amount of nicotine exchanged per 1 g of cation exchanger: g / g) = (Amount of nicotine exchanged per 1 g of cation exchanger: g / g) (ion exchange capacity: mol / g) × (molecular weight of nicotine: 162.23 g / mol) (1)

[0081] [Table 5]

[0082] From Table 5, the ion exchange capacity of the cation exchanger is as follows: ion exchange resin > pectin (low methoxide) (c), Tragacanth gum > Gellan gum (deacylated) ≒ Xanthan gum ≒ Gum arabic It was found that the ion exchange capacity is related to the nicotine content of the composition. Furthermore, it was found that sodium alginate further reduces the ion exchange capacity, and carrageenan has no ion exchange capacity. The present inventors speculate that an oral composition produced using a material with a high nicotine exchange capacity is advantageous in improving the freedom of product design because the nicotine content of the product can be controlled without the need to incorporate a large amount of nicotine carrier.

[0083] <Test 4> To 30 mL of ultrapure water, nicotine ion exchange resin (20% Nicotine Polacrilex manufactured by Contraf nicotex) was added so that the concentration was 1.0 mg / mL, and HCl (hydrochloric acid manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.) was added so that the proton concentration was the value shown in Table 6 below, and the mixture was stirred at 200 rpm for 60 minutes to obtain each oral composition. The content of the nicotine exchange resin, which is an ion exchanger, in the oral composition was about 0.1% by weight. Since the oral composition does not contain any nicotine other than that derived from nicotine polacrilex, the content of nicotine in the oral composition was found to be about 0.02% by weight. The pH and nicotine dissolution rate of the oral composition were measured in the same manner as in Experiment 1. The evaluation results are shown in Table 6 and FIG.

[0084] [Table 6]

[0085] From Table 6 and Figure 8, the proton concentration is 6 × 10 -5 It was found that at 1.0 mol / L, 50% or more of nicotine was dissolved, and the dissolution rate of nicotine increased depending on the proton concentration. + The inventors speculate that by providing as a cation, it is possible to improve the dissolution rate of nicotine.

Claims

1. An oral composition comprising a cation exchanger having a cation exchange capacity of 0.06 mmol / g or more and capable of carrying nicotine, and a cation donor.

2. The oral composition of claim 1 , wherein the cation exchanger is selected from the group consisting of anionic polymers, ion exchange resins, and combinations thereof.

3. The oral composition according to claim 2 , wherein the cation exchanger is at least one selected from the group consisting of ion exchange resins, pectin, tragacanth gum, gellan gum, xanthan gum and gum arabic.

4. The oral composition according to any one of claims 1 to 3, wherein the cation in the cation donor is a monovalent or divalent cation.

5. The cation of the cation donor is Na ＋ , N.H. ４ ＋ , K ＋ , Mg ２＋ , Ca ２＋ , and H ＋ The oral composition according to claim 4, wherein the oral composition is one or more selected from the group consisting of:

6. The cation of the cation donor is NH ４ ＋ , Mg ２＋ , and Ca ２＋ The oral composition according to claim 5 , wherein the oral composition is one or more selected from the group consisting of:

7. The oral composition according to any one of claims 1 to 6, wherein the concentration of the cation donor is 0.025 mol / L or more.

8. The oral composition according to any one of claims 1 to 7, which has a pH of 2 or more and 9 or less.

9. The cation of the cation donor is H ＋ The oral composition according to claim 4 ,

10. The H ＋ The concentration of is 1 x 10 －５ 10. The oral composition according to claim 9, wherein the oral composition has a pH of 10.

11. The oral composition according to claim 9 or 10, having a pH of 2.0 or more and 5.0 or less.

12. The oral composition according to any one of claims 1 to 11, wherein the content of the cation exchanger is 1 wt% or more.

13. The oral composition according to any one of claims 1 to 12, wherein the cation exchanger is one or more selected from the group consisting of pectin, tragacanth gum, gellan gum, xanthan gum and gum arabic, and the total content of the cation exchangers is 20% by weight or more.

14. An oral pouch product comprising the oral composition according to any one of claims 1 to 13 and a pouch for packaging the composition for oral tobacco products.

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