Atomized liquid, preparation method of atomized liquid and electronic atomization device

Abstract

The invention provides atomized liquid. The atomized liquid is prepared from nicotine, cytisine and a solvent. By using the cytisine which has a synergistic effect with the nicotine, on the premise that the dosage of the nicotine is not increased, the atomized liquid which is better in satisfaction and better in tobacco addiction relieving effect is provided.

Description

Technical Field

[0001] The embodiments of the present application relate to the field of atomization liquids, and in particular, to an atomization liquid containing nicotine and cytisine. Background Art

[0002] As a substitute for traditional cigarettes, electronic cigarette atomization liquids contain the physiologically active substance nicotine. Users inhale nicotine by sucking on an electronic cigarette to create a physiological sense of satisfaction similar to that of sucking on a traditional cigarette. Summary of the Invention

[0004] In order to provide an electronic cigarette atomization liquid with a good sucking experience and addiction relief, an embodiment of the present application provides an atomization liquid, which includes: nicotine, cytisine, and a solvent.

[0005] In the atomization liquid provided by an embodiment of the present application, the mass fraction of nicotine in the atomization liquid is 0.50 - 3.00%.

[0006] In the atomization liquid provided by an embodiment of the present application, the mass fraction of cytisine is 0.50 - 5.00%.

[0007] In the atomization liquid provided by an embodiment of the present application, the mass fraction of the solvent is 50.00 - 99.90%.

[0008] In the atomization liquid provided by an embodiment of the present application, the mass fraction of nicotine is 1.00 - 2.00%.

[0009] In the atomization liquid provided by an embodiment of the present application, the mass fraction of cytisine is 1.00 - 4.00%.

[0010] In the atomization liquid provided by an embodiment of the present application, the cytisine includes the free base of cytisine.

[0011] In the atomization liquid provided by an embodiment of the present application, the cytisine includes cytisine salts.

[0012] In the atomization liquid provided by an embodiment of the present application, the cytisine salts are formed by the reaction of cytisine with organic acids, and the organic acids are selected from one or a combination of formic acid, acetic acid, propionic acid, butyric acid, α-furoic acid, α-methylfuranbutyric acid, isovaleric acid, β-methylvaleric acid, levulinic acid, lactic acid, citric acid, malic acid, tartaric acid, succinic acid, oxalic acid, maleic acid, glycolic acid, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, benzoic acid, phenylacetic acid, caffeic acid, coumaric acid, phthalic acid, terephthalic acid.

[0013] In the atomizing liquid provided by an embodiment of the present application, a sweetening agent is further included, and the mass fraction of the sweetening agent is 0.01 - 0.60%.

[0014] In the atomizing liquid provided by an embodiment of the present application, the sweetening agent includes one or a combination of several of neotame, sodium cyclamate, sucralose, aspartame, stevioside, acesulfame potassium, mogroside.

[0015] In the atomizing liquid provided by an embodiment of the present application, a cooling agent is further included, and the mass fraction of the cooling agent is 0.10 - 8.00%.

[0016] In the atomizing liquid provided by an embodiment of the present application, the cooling agent includes one or a combination of several of menthol, menthone, isomenthone, 2 - isopropyl - N,2,3 - trimethylbutyramide, N - ethyl - p - menthane - 3 - carboxamide, N - (ethoxycarbonylmethyl) - p - menthane - 3 - carboxamide.

[0017] In the atomizing liquid provided by an embodiment of the present application, a flavor composition is further included, and the mass fraction of the flavor composition is 1.00 - 20.00%.

[0018] In the atomizing liquid provided by an embodiment of the present application, the solvent includes one or a mixture of several of propylene glycol, butylene glycol, 1,2,4 - butanetriol, dipropylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol 200, polyethylene glycol 400, triacetin, glycerol, dipropylene glycol ether, ethanol, water, triethyl citrate, caprylic / capric glycerides.

[0019] An embodiment of the present application further provides a method for preparing an atomizing liquid, including:

[0020] Weigh nicotine, cytisine, and a solvent according to a certain weight ratio;

[0021] Add cytisine to the solvent, stir, and dissolve to obtain a first mixture;

[0022] Add nicotine to the first mixture, stir, and obtain a second mixture;

[0023] Filter the second mixture to obtain the atomizing liquid.

[0024] In the method for preparing an atomizing liquid provided by an embodiment of the present application, in the process of adding cytisine to the solvent, stirring, and dissolving to obtain a first mixture, adding a sweetening agent and a cooling agent to the solution is further included.

[0025] In the method for preparing an atomizing liquid provided by an embodiment of the present application, in the process of adding nicotine to the first mixture, stirring, and obtaining a second mixture, adding a flavor composition to the first mixture is further included.

[0026] An embodiment of the present application further provides an electronic atomization device, including the atomization liquid provided in the above embodiment and an atomizer, where the atomizer is used to heat and atomize the atomization liquid to generate an aerosol.

[0027] The present application provides an atomization liquid, a preparation scheme of the atomization liquid, and an electronic atomization device. Using cytisine that has a synergistic effect with nicotine, a better atomization liquid with a better sense of satisfaction and a better effect of relieving nicotine addiction is provided without increasing the dosage of nicotine. Description of the Drawings

[0028] One or more embodiments are exemplarily illustrated by pictures in the corresponding drawings. These exemplary illustrations do not limit the embodiments. Elements with the same reference numerals in the drawings represent similar elements. Unless otherwise stated, the drawings in the figures do not constitute a proportional limitation.

[0029] Figure 1 It is a comparison chart of the nicotine addiction relief score for Embodiments 1-3 and Comparative Example 1 of the present application;

[0030] Figure 2 It is a comparison chart of the nicotine addiction relief score for Embodiments 4-6 and Comparative Example 2 of the present application;

[0031] Figure 3 It is a comparison chart of the nicotine addiction relief score for Embodiment 7 and Comparative Example 3 of the present application;

[0032] Figure 4 It is a comparison chart of the nicotine addiction relief score for Embodiment 8 and Comparative Example 4 of the present application;

[0033] Figure 5 It is a comparison chart of the nicotine addiction relief score for Embodiments 9-11 and Comparative Example 5 of the present application. Detailed Description of the Embodiments

[0034] To facilitate the understanding of the present application, the present application will be described in more detail below in conjunction with the drawings and specific embodiments.

[0035] Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative efforts belong to the scope of protection of the present application.

[0036] References to "embodiments" in this specification mean that specific features, structures, or characteristics described in connection with the embodiments can be included in at least one embodiment of the present application. The phrase appears in various places in the specification and does not necessarily refer to the same embodiment each time, nor are they independent or alternative embodiments mutually exclusive of other embodiments. Those skilled in the art will explicitly and implicitly understand that the embodiments described herein can be combined with other embodiments.

[0037] An embodiment of the present application provides an atomization liquid, which includes nicotine, cytisine, and a solvent. By using cytisine that has a synergistic effect with nicotine, an atomization liquid with a better sense of satisfaction and a better effect of relieving nicotine addiction can be provided without increasing the dosage of nicotine.

[0038] In an embodiment of the present application, the mass fraction of nicotine in the atomization liquid is 0.50 - 3.00%.

[0039] In an embodiment of the present application, the mass fraction of cytisine is 0.50 - 5.00%.

[0040] In an embodiment of the present application, the mass fraction of the solvent is 50.00 - 99.90%.

[0041] Nicotine is an important component of e - cigarette liquid. Nicotine can exist in the form of free base or salt. Early e - cigarettes generally used nicotine free base. The volatile nicotine free base has a relatively strong irritation and a strong throat hit feeling. It is mainly absorbed through the mouth and throat and is difficult to enter the lungs, resulting in a relatively small amount entering the lungs, so the experience is relatively poor. The use of nicotine salt has further developed e - cigarettes. Since nicotine salt has relatively low volatility and less throat irritation, the smoke becomes smoother after using nicotine salt, and more aerosol enters the lungs to participate in lung absorption, thus improving the experience of e - cigarettes.

[0042] The molecular formula of cytisine is C 11 H 14 N 2 O, with Chinese aliases such as baptifoline and ulexine. It is a natural bioactive compound, first isolated from Cytisus scoparius by Husemann and Marme in 1865. It mainly exists in plants of the genus Sophora, Thermopsis, or Berberidaceae, such as Cytisus scoparius, Sophora flavescens, and Sophora alopecuroides. Its characteristic is that it has a relatively high affinity for neuronal nicotinic acetylcholine receptors, is specific for the α subtype, and is a partial agonist of nicotinic acetylcholine receptors. Modern research shows that cytisine has various pharmacological effects, such as smoking cessation, enhancing myocardial contractility, exciting respiration, antidepressant, dopamine neurotransmission, enhancing motor ability, improving cognitive function, analgesia, and anti - tumor.

[0043] The purpose of this application is to utilize the synergistic effect of anabasine, a partial agonist of nicotinic acetylcholine, on nicotine, so that the e-liquid can have better puffing satisfaction and higher nicotine reduction efficiency without increasing the nicotine dosage, in order to better meet the needs of consumers who want to substitute smoking; use anabasine to partially replace nicotine to achieve a comprehensive experience of synergistic enhancement, reduce the nicotine dosage, and achieve the satisfaction of the e-liquid with the usual dosage (20mg / ml) on the market with a low-dose nicotine e-liquid, thereby reducing the nicotine exposure, further reducing the addiction and health hazard risks of e-cigarettes, and making e-cigarettes a more effective tool for substituting and quitting smoking.

[0044] In some embodiments and comparative examples of this application, the components of the e-liquid are shown in Table 1-2, and the components of the e-liquid in Table 1 and Table 2 are all calculated by mass fraction.

[0045] The above-mentioned embodiments and comparative examples are loaded into the same e-cigarette device, and professional smokers conduct a comprehensive sensory quality evaluation from multiple dimensions, including 7 dimensions: aerosol amount, aroma quality, sweetness, coolness, irritation, dizziness, and continuous effect. Among them, irritation, dizziness, and continuous effect are related to the nicotine reduction efficiency of the e-liquid. The specific evaluation indicators are shown in Table 3.

[0046] Table 1 Components of the e-liquid in each embodiment and comparative example

[0047]

[0048]

[0049] Table 2 Components of the e-liquid in each embodiment and comparative example

[0050]

[0051] Table 3 Comprehensive sensory evaluation indicators of the e-liquid

[0052]

[0053] According to the above sensory evaluation criteria, 7 professional smokers conduct a sensory evaluation on the above-mentioned embodiments and comparative examples. Each sample is evaluated 3 times, and the results are averaged. The obtained scores are shown in Table 4.

[0054] Table 4 Sensory evaluation of the e-liquid in each embodiment and comparative example

[0055]

[0056] As Figures 1-5As shown, in Comparative Example 1 and Examples 1-3, the mass fraction of nicotine is 1.80%, the mass fraction of cytisine increases from 0 to 3.00%, and 15.00% of mango essence is added to the flavor composition. It can be seen that in the mango-flavored e-liquid, as the mass fraction of cytisine increases, the addiction relief degree of the e-liquid is significantly improved. In Comparative Example 2 and Examples 4-6, the mass fraction of nicotine is 1.60%, the mass fraction of cytisine increases from 0 to 2.80%, and the flavor composition is 2.00% of tobacco extract and 12.00% of tobacco essence. It can be seen that in the tobacco-flavored e-liquid, as the mass fraction of cytisine increases, the addiction relief degree of the e-liquid is significantly improved. In Example 7 and Comparative Example 3, the mass fraction of nicotine is 3.00%, the mass fraction of cytisine increases from 0 to 2.50%, and the flavor composition is blueberry essence. It can be seen that in the blueberry-flavored e-liquid, as the mass fraction of cytisine increases, the addiction relief degree of the e-liquid is significantly improved. In Comparative Example 4 and Example 8, the mass fraction of nicotine is 0.50%, the mass fraction of cytisine increases from 0 to 5.00%, and the flavor composition is 13.00% of grape essence. It can be seen that in the grape-flavored e-liquid, as the mass fraction of cytisine increases, the addiction relief degree of the e-liquid is significantly improved. In Comparative Example 5 and Examples 9-11, the mass fraction of nicotine decreases from 2.00% to 1.00%, the mass fraction of cytisine increases from 0 to 4.00%, and the addiction relief degree of the e-liquid can still be maintained at a certain level. It can be seen that when the nicotine content is reduced and the cytisine content is increased, using cytisine to replace a part of nicotine can achieve a synergistic comprehensive experience.

[0057] As can be seen from Table 3, when the mass fraction of nicotine in Example 8 is 0.50%, the scores of irritation, dizziness, and sustained effect of the e-liquid are 2.86, 2.71, and 2.07 respectively. While the mass fraction of nicotine in Example 11 is 1.00%, and at this time, the scores of irritation, dizziness, and sustained effect of the e-liquid are 4.25, 3.32, and 3.12 respectively, and the addiction relief degree of the e-liquid has a relatively high improvement. And the European Union stipulates that the nicotine content in e-cigarettes is lower than 2.00%. Therefore, in some embodiments of the present application, the mass fraction of nicotine in the e-liquid is 1.00-2.00%, and at this time, the addiction relief degree of the e-liquid is relatively high.

[0058] In some embodiments of the present application, the mass fraction of cytisine is 1.00-5.00%. When the mass fraction of cytisine is within this range and the mass fraction of nicotine remains unchanged, as the mass fraction of cytisine increases, the addiction relief degree of the e-liquid is significantly improved. Therefore, in terms of improving the addiction relief degree, cytisine and nicotine have a synergistic effect.

[0059] In some embodiments of the present application, the mass fraction of cytisine is 1.00 - 4.00%. Referring to Comparative Example 5 and Examples 9 - 11, when the mass fraction of nicotine is 1.00 - 2.00%, reducing the mass fraction of nicotine and using cytisine to replace a part of nicotine, at this time the mass fraction of cytisine is 1.00 - 4.00%, which can maintain the addiction relief degree of the e - liquid at a certain level. That is, cytisine can be used to partially replace nicotine to achieve a synergistic and enhanced comprehensive experience, reduce the dosage of nicotine, and achieve the satisfaction of the e - liquid with the usual dosage (20mg / ml) on the market with a low - dose nicotine e - liquid, thereby reducing the nicotine exposure, further reducing the addiction and health - hazard risks of e - cigarettes, and making e - cigarettes a more effective tool for substituting and quitting smoking.

[0060] In some embodiments of the present application, the mass fraction of cytisine is 1.00 - 3.00%. Referring to Comparative Example 1 and Examples 1 - 3, when nicotine is at a preset value, during the process of increasing the mass fraction of cytisine from 1.00% to 3.00%, the addiction relief degree of the e - liquid is significantly improved, and the synergistic effect of cytisine and nicotine on the addiction relief degree is relatively significant.

[0061] In some embodiments of the present application, the cytisine includes the free base of cytisine.

[0062] In some embodiments of the present application, the cytisine includes cytisine salts.

[0063] In some embodiments of the present application, the cytisine salts are formed by the reaction of cytisine with organic acids. The organic acids are selected from one or a combination of formic acid, acetic acid, propionic acid, butyric acid, α - furancarboxylic acid, α - furanmethylbutyric acid, isovaleric acid, β - methylvaleric acid, levulinic acid, lactic acid, citric acid, malic acid, tartaric acid, succinic acid, oxalic acid, maleic acid, glycolic acid, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, benzoic acid, phenylacetic acid, caffeic acid, coumaric acid, phthalic acid, terephthalic acid.

[0064] In some embodiments of the present application, the e - liquid further includes a sweetening agent, and the mass fraction of the sweetening agent is 0.01 - 0.60%.

[0065] In some embodiments of the present application, the sweetening agent includes one or a combination of neotame, sodium cyclamate, sucralose, aspartame, stevioside, acesulfame - K, mogroside.

[0066] In some embodiments of the present application, the e - liquid further includes a cooling agent, and the mass fraction of the cooling agent is 0.10 - 8.00%.

[0067] In some embodiments of the present application, the cooling agent includes one or a combination of several of menthol, menthone, isomenthone, WS-23 (2-isopropyl-N,2,3-trimethylbutyramide), WS-3 (N-ethyl-p-menthane-3-carboxamide), and WS-5 (N-(ethoxycarbonylmethyl)-p-alkane-3-carboxamide).

[0068] In some embodiments of the present application, the atomizing liquid further includes a flavor composition, and the mass fraction of the flavor composition is 1.00-20.00%.

[0069] In some embodiments of the present application, the atomizing liquid further includes a flavor composition, and the mass fraction of the flavor composition is 10.00-15.00%.

[0070] In some embodiments of the present application, the solvent includes one or a mixture of several of propylene glycol, butylene glycol, 1,2,4-butanetriol, dipropylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol 200, polyethylene glycol 400, triacetin, glycerol, dipropylene glycol dimethyl ether, ethanol, water, triethyl citrate, and glyceryl caprylate.

[0071] In some embodiments of the present application, the addition amounts of the sweetening agent, the cooling agent, and the flavor composition can be determined according to the needs of users, and are not limited to the contents and types provided in this specification.

[0072] One embodiment of the present application further provides a method for preparing an atomizing liquid, including:

[0073] Weigh nicotine, cytisine, and a solvent according to a certain weight ratio;

[0074] Add cytisine to the solvent, stir, and dissolve to obtain a first mixture;

[0075] Add nicotine to the first mixture, stir, and obtain a second mixture;

[0076] Filter the second mixture to obtain the atomizing liquid.

[0077] In some embodiments of the present application, in the process of adding cytisine to the solvent, stirring, and dissolving to obtain a first mixture, adding the sweetening agent and the cooling agent to the solution is further included.

[0078] In some embodiments of the present application, in the process of adding nicotine to the first mixture, stirring, and obtaining a second mixture, adding the flavor composition to the first mixture is further included.

[0079] In some embodiments of the present application, in the process of filtering the second mixture to obtain the atomizing liquid, a filter cloth with 80-120 meshes is used for filtering.

[0080] In some embodiments of the present application, a method for preparing an atomization liquid is provided, including:

[0081] Weigh nicotine, cytisine, sweetener, cooling agent, flavor composition and solvent according to a certain weight ratio;

[0082] Add the sweetener, cooling agent and cytisine into the solvent, stir and dissolve to obtain a first mixture;

[0083] Add the nicotine and flavor composition into the first mixture, stir to obtain a second mixture;

[0084] Filter the second mixture through a filter cloth with a mesh size of 80-120 to obtain the atomization liquid.

[0085] An embodiment of the present application further provides an electronic atomization device, including the atomization liquid and an atomizer provided in the above embodiments. The atomizer is used to atomize the above atomization liquid to generate an aerosol. In some examples, the atomizer may employ a heating element that utilizes methods such as resistance heating, electromagnetic induction heating, infrared radiation heating or microwave heating; in other examples, the atomizer may employ a high-frequency vibration element to atomize the atomization liquid to form aerosol particles, such as an ultrasonic atomization sheet.

[0086] It should be noted that the description and drawings of the present application give preferred embodiments of the present application, but are not limited to the embodiments described in this specification. Further, for those of ordinary skill in the art, modifications or variations can be made based on the above description, and all such modifications and variations should fall within the protection scope of the appended claims of the present application.

Claims

1. An atomizing liquid, characterized in that, the atomizing liquid comprises: nicotine, cytisine, and a solvent.

2. The atomizing liquid according to claim 1, characterized in that, the mass fraction of nicotine in the atomizing liquid is 0.50 - 3.00%.

3. The atomizing liquid according to claim 1, characterized in that, the mass fraction of cytisine is 0.50 - 5.00%.

4. The atomizing liquid according to claim 1, characterized in that, the mass fraction of the solvent is 50.00 - 99.90%.

5. The atomizing liquid according to claim 1, characterized in that, the mass fraction of nicotine is 1.00 - 2.00%.

6. The atomizing liquid according to claim 1, characterized in that, the mass fraction of cytisine is 1.00 - 4.00%.

7. The atomizing liquid according to claim 1, characterized in that, the cytisine includes the free base of cytisine.

8. The atomizing liquid according to claim 1, characterized in that, the cytisine includes cytisine salts.

9. The atomizing liquid according to claim 8, characterized in that, the cytisine salt is formed by the reaction of cytisine with an organic acid, and the organic acid is selected from one or a combination of formic acid, acetic acid, propionic acid, butyric acid, α - furanpropionic acid, α - furanmethylbutyric acid, isovaleric acid, β - methylvaleric acid, levulinic acid, lactic acid, citric acid, malic acid, tartaric acid, succinic acid, oxalic acid, maleic acid, glycolic acid, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, benzoic acid, phenylacetic acid, caffeic acid, coumaric acid, phthalic acid, terephthalic acid.

10. The atomizing liquid according to claim 1, characterized in that, it further includes a sweetener, and the mass fraction of the sweetener is 0.01 - 0.60%.

11. The atomizing liquid according to claim 10, characterized in that, the sweetener includes one or a combination of neotame, sodium cyclamate, sucralose, aspartame, stevioside, acesulfame potassium, mogroside.

12. The atomizing liquid according to claim 1, characterized in that, it further includes a cooling agent, and the mass fraction of the cooling agent is 0.10 - 8.00%.

13. The atomizing liquid according to claim 12, characterized in that, the cooling agent includes one or a combination of menthol, menthone, isomenthone, 2 - isopropyl - N,2,3 - trimethylbutyramide, N - ethyl - p - menthane - 3 - carboxamide, N - (ethoxycarbonylmethyl) - p - menthane - 3 - carboxamide.

14. The atomizing liquid according to claim 1, characterized in that, it further includes a flavor composition, and the mass fraction of the flavor composition is 1.00 - 20.00%.

15. The atomizing liquid according to claim 1, characterized in that, the solvent includes one or a mixture of propylene glycol, butylene glycol, 1,2,4 - butanetriol, dipropylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol 200, polyethylene glycol 400, triacetin, glycerol, dipropylene glycol dimethyl ether, ethanol, water, triethyl citrate, caprylic / capric triglyceride.

16. A method for preparing an atomization liquid, comprising: weighing nicotine, cytisine and a solvent according to a certain weight ratio; adding the cytisine to the solvent, stirring and dissolving to obtain a first mixture; adding the nicotine to the first mixture, stirring to obtain a second mixture; filtering the second mixture to obtain the atomization liquid.

17. The atomization liquid according to claim 16, characterized in that in the process of adding the cytisine to the solvent, stirring and dissolving to obtain a first mixture, it further includes adding a sweetening agent and a cooling agent to the solution.

18. The atomization liquid according to claim 16, characterized in that in the process of adding the nicotine to the first mixture, stirring to obtain a second mixture, it further includes adding a flavor composition to the first mixture.

19. An electronic atomization device, comprising an atomizer and the atomization liquid according to any one of claims 1-15, wherein the atomizer is used to atomize the atomization liquid to generate an aerosol.

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