Blood-pressure-lowering (antihypertensive) composition

Abstract

To produce an antihypertensive that takes measures for a calcium concentration not to get low, thereby overcoming the shortcomings the existing antihypertensive now has that, since it does not possess a mechanism for adequately maintaining a calcium concentration, calcium insufficiency occurs if taken for a long time, that calcium is taken away from bones more than necessary, that excess calcium flows into blood, brain, cartilage, etc., and that arterial sclerosis, calculus, etc. are liable to occur.SOLUTION: A composition contains lactic acid-producing bacteria, water-soluble, fermentable edible fibers, and carcasses of coral, shellfish, dried sardine, etc. that were alive in the past.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to a composition for lowering blood pressure which contains butyric acid-producing bacteria, water-soluble and fermentable dietary fiber, dried sardines, etc. as essential ingredients. [Background technology]

[0002] There are several types of blood pressure lowering drugs, among which amlodipine is classified as a "calcium antagonist" and is widely used. Calcium antagonists work by blocking the calcium channels present in the smooth muscle that surrounds blood vessels. A calcium channel is a hole through which calcium can pass. Normally, when calcium ions enter smooth muscle cells through a calcium channel, the muscle contracts due to the stimulation. When the muscle contracts, the blood vessels tighten and blood pressure rises. Amlodipine blocks this. Amlodipine closes the calcium channel, preventing calcium ions from entering the smooth muscle. When the muscle cannot contract, the blood vessels expand. When the blood vessels expand, blood pressure drops (Non-Patent Document 1). However, recently, the description of side effects of Amlodipine has been expanded to include impairment of liver function (elevated ALT, AST, elevated γ-GTP, etc.) (Non-Patent Document 2). Although Amlodipine is a convenient drug, it is a compound and must be broken down, so it is used as an antihypertensive drug by many people at the expense of liver function. Antihypertensive drugs are often used for a long time once they are started, so safety during long-term use is also required in the future. In order to solve the problem of amlodin causing liver dysfunction, attempts are being made to create antihypertensive drugs from food. Sardine peptide, a substance obtained by extracting and concentrating protein from sardines, is said to be able to lower blood pressure by inhibiting the action of the conversion enzyme that produces a substance that is believed to cause high blood pressure. Since sardine peptide is originally a food, unlike amlodin, there is no need to worry about side effects even if it is used for a long time (Non-Patent Document 3). However, these two methods (amlodin and sardine peptide) do not have a mechanism for replenishing calcium little by little, so there is a risk of calcium deficiency and the calcium paradox described below.

[0003] The human body has a mechanism for regulating the concentration of calcium ions in the blood in order to maintain life. When calcium levels are insufficient, parathyroid hormone is secreted to remove calcium from the bones, which are calcium stores, and regulate calcium levels. If parathyroid hormone issues commands too frequently, the amount exceeds the required amount. This excess calcium can enter the blood vessels, brain, cartilage, etc., making it easier to develop arteriosclerosis and stones. This phenomenon, in which calcium deficiency ultimately leads to calcium excess, is sometimes referred to as the calcium paradox. Therefore, it is necessary to continue taking calcium in small amounts every day (Non-Patent Document 4).

[0004] The "Calcium Topics" section of the Corbion Japan Co., Ltd. website describes the mechanism by which calcium deficiency causes high blood pressure. When it comes to preventing high blood pressure, reducing sodium intake is a well-known method, but it is also known that high blood pressure can be caused by insufficient calcium intake. The mechanism by which calcium deficiency causes high blood pressure is described below. Blood pressure is determined by the amount of blood and how difficult it is to pass through the blood vessels. Therefore, when the inside of the blood vessels narrows and blood flow becomes difficult, the heart has to pump blood with greater force, causing blood pressure to rise. So what causes the inside of blood vessels to narrow? When calcium intake is insufficient, parathyroid hormone is secreted, dissolving calcium from bones, which are calcium storage, in an attempt to return the calcium concentration in the blood to normal. Parathyroid hormone also works to take calcium into cells, so calcium enters the smooth muscle of blood vessels and causes the muscles to contract. This action narrows the inside of blood vessels, causing high blood pressure. It is also known that among hypertensive patients, the lower the calcium intake, the less sodium is excreted in urine. In other words, consuming a lot of calcium causes natriuresis (excretion of a lot of sodium in urine), which lowers blood pressure. It is thought that in order to prevent high blood pressure, it is important to avoid excessive sodium intake and consume a lot of calcium (Non-Patent Document 5).

[0005] (Intestinal calcium absorption by butyric acid) It is stated that "when calcium phosphate reaches the large intestine, if intestinal fermentation by enterobacteria is active, the pH of the contents becomes acidic due to the butyric acid produced, and the insoluble calcium salts become soluble and can be absorbed." It has been made clear that calcium phosphate is absorbed from the intestinal tract by the butyric acid produced in the large intestine (Non-Patent Document 6).

[0006] (Butyric acid participates in bone formation) Butyric acid activates osteoblasts and promotes bone formation (Non-Patent Document 7). Even if an excess of calcium butyrate is absorbed from the intestinal tract, this is thought to pose little problem, since the calcium is absorbed into the bones through the action of butyric acid.

[0007] In (Patent Document 1) JP-A-03-011097, the antihypertensive agent is not an artificial compound but a food, so there is no harm in taking it for a long time. However, since there is no idea of ​​supplementing calcium little by little, if you consider using it for a long time, side effects such as arteriosclerosis cannot be avoided due to the calcium paradox.

[0008] (Patent Document 2) JP 2007-223924 proposes a calcium-based material called weathered reef-building coral powder as a blood pressure lowering agent. However, since there is no mechanism for the body to absorb calcium, it is thought that people with low levels of acidic substances may not be able to absorb enough calcium to lower their blood pressure.

[0009] On the other hand, (Patent Document 3) Patent No. 5606672 is a patent that regulates the intestinal environment and reliably produces intestinal bacteria in the large intestine. However, there is no mention of the application of butyric acid, such as the absorption of calcium into the body. [Prior art documents] [Patent documents]

[0010] [Patent Document 1] Patent Publication No. 03-011097 [Patent Document 2] Patent Publication No. 2007-223924 [Patent Document 3] Patent No. 5606672 [Non-patent literature]

[0011] [Non-Patent Document 1] Hidamari Clinic Doctor's prescription explanation https: / / druginfomation-clinic.com / amlodipin2-efect / Effects and side effects of Amlodipine (antihypertensive drug) [Non-Patent Document 2] Amlodipine Drug Information For literature requests and inquiries, please contact Sumitomo Farm Co., Ltd. Drug Information Center 2-6-8 Doshomachi, Chuo-ku, Osaka 541-0045, Japan 0120-034-389 [Non-Patent Document 3] The mechanism by which sardine peptides are effective against high blood pressure is https: / / medical-checkup.biz / archives / 18992 [Non-Patent Document 4] What you need to know about the "Calcium Paradox" http: / / www.calcium-ion.jp / 20140331 / 784 [Non-Patent Document 5] The mechanism by which calcium deficiency causes high blood pressure http: / / www.calcium-ion.jp / 20120220 / 820 [Non-Patent Document 6] Hiroshi Hara, The role of calcium and its absorption: new developments, Chemistry and Biology vol 46 No 6, 2008: 412-419 415 pages [Non-Patent Document 7] Yuji Naito, "Increasing butyric acid bacteria will lead to health and longevity," Asa Publishing, pages 71-72 Summary of the Invention [Problem to be solved by the invention]

[0012] High blood pressure is a typical lifestyle-related disease, and the number of patients is increasing year by year. Since it can lead to serious disorders such as cerebral hemorrhage, cerebral infarction, heart failure, angina pectoris, myocardial infarction, and kidney failure, it cannot be ignored, and antihypertensive drugs must be taken for a long time. However, calcium antagonists such as amlodipine are synthetic, and can cause liver damage when detoxifying them. Some methods have been developed that use protein as food to overcome this drawback. However, since neither method has a mechanism for continuously ingesting calcium in small amounts, long-term use can lead to calcium deficiency, and a calcium paradox occurs due to the action of parathyroid hormone, which causes more calcium to be removed from bones than necessary, and the excess calcium enters blood vessels, the brain, cartilage, etc., which can easily cause arteriosclerosis and stones.

[0013] The object of the present invention is to develop a safe antihypertensive agent which does not burden the liver even when used for a long period of time, is free from the risk of calcium paradox resulting from the action of parathyroid hormone, and is free from the risk of excess calcium penetrating into blood vessels, brain, cartilage, etc., and causing arteriosclerosis, stones, etc. [Means for solving the problem]

[0014] The intestinal bacteria used as the raw material are called butyric acid bacteria or butyric acid-producing bacteria, a type of beneficial bacteria that live in the large intestine, and are found in fermented foods such as pickled vegetables and cheese, and are known as bacteria that produce short-chain fatty acids (butyric acid). In the atmosphere, they exist in the form of sprouts, and in the large intestine, they first sprout in an oxygen-free, acidic environment, and produce butyric acid by feeding on water-soluble, fermentable dietary fiber. There are no particular restrictions as long as they have this function. Clostridium butyricum is commercially available, so this is convenient.

[0015] The fermentable, water-soluble dietary fibers that serve as food for butyric acid bacteria include guar gum hydrolysate, resistant dextrin, agar, polydextrose, etc., of these, guar gum hydrolysate has a high fermentation rate and is excellent as food for intestinal bacteria. There is a convenient product available on the market as a supplement for intestinal regulation that combines guar gum hydrolysate and butyric acid bacteria powder.

[0016] Good sources of calcium are corals, shellfish, dried sardines, and other remains of past living things that contain calcium as well as other metals such as magnesium. Of these, dried sardines are convenient because they can be purchased as food at supermarkets. Dried sardines contain oils with unsaturated bonds and are prone to oxidizing, absorbing moisture, and growing mold when exposed to oxygen, but as long as they have been processed so that they do not deteriorate during storage, the type and size of the fish are not important.

[0017] There is no particular method for processing these ingredients, but it is preferable to put them into a container, rotate a propeller, and crush them to a level where the particles cannot be felt by the tongue. Based on these ingredients, vegetables, fruits, water, soy milk, milk, fruit juice, etc. It can be drunk as a smoothie containing the three essential ingredients. However, the three essential ingredients are separated, and it is not recommended to take them at different times, as this reduces the effectiveness of the product. In addition, it is necessary to keep the intestinal environment in good condition, so it is important to be conscious of cultivating intestinal bacteria on a regular basis.

[0018] It is hypothesized that the blood pressure lowering effect of these ingredients is due to the following principle. Water-soluble and fermentable dietary fiber is the food, and butyrate is produced by butyrate-producing bacteria. The epithelial cells of the large intestine consume butyrate and oxygen without relying on the blood flowing through the body for energy. As a result, the intestinal environment becomes acidic and oxygen-free. With this environment in place, butyric acid is produced by butyric acid-producing bacteria, which reacts with the calcium ions in the dried sardine powder to produce calcium butyrate. Calcium butyrate is absorbed through the intestinal wall, and sodium ions are excreted along with the calcium ions (natriuresis), resulting in a drop in blood pressure. However, a small amount of calcium ions remains, dramatically reducing the frequency of calcium loss from bones due to parathyroid hormone, eliminating the calcium paradox and improving conditions such as arteriosclerosis. On the other hand, even if too much calcium is taken in, there are documents that say that the butyric acid taken in by the body acts on the cells that form bones and helps with bone formation, so I assume that it won't be a problem. Effect of the Invention

[0019] The subject of this experiment was a 75-year-old male. The blending, preparation method, intake method, and blood pressure measurement in Examples 1 and 2 in Table 1 were as follows: (blending), (preparation method), (intake method), and (blood pressure measurement). The blending of Comparative Example 1 was carried out without adding dried sardines. Other than that, the blending was carried out in the same manner as in Examples 1 and 2. Example 1 was carried out from May 13th to May 22nd, and the average systolic blood pressure was 121 mmHg. Comparative Example 1 was conducted from May 23rd to May 27th, and the average systolic blood pressure was 132mmHg. Example 2 was conducted from May 28th to June 5th, and the average systolic blood pressure was 123mmHg. From this result, it was found that the comparative example was 10 mmHg higher than the example. The comparative example did not contain dried sardines, proving the effect of dried sardines. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0020] (Composition) As for water-soluble and fermentable dietary fiber + butyric acid bacteria, there is "Sun Fiber +" by Taiyo Labo Co., Ltd., in stick form: 1 packet (contents: guar gum hydrolyzate, 5g, Clostridium butyricum 1g), dried sardines: sold by Yaoko Co., Ltd. (contents: hard-mouthed sardines, ready-to-eat type) 5g, water: 180g

[0021] (Adjustment method) The formulation was milled, mixed in a Vitamix Blender Professional Series 500 for 5 minutes and processed into a drink.

[0022] (How to take) It was taken daily before breakfast between 6:30 and 7:30 am.

[0023] (Blood pressure measurement) Using a Panasonic Electric Works automatic blood pressure monitor EW243, measurements were taken three times between 8:00 and 9:00, and the average value was used as the representative value.

[0024] [Table 1]

Claims

1. A composition for lowering blood pressure, comprising butyric acid-producing bacteria, water-soluble and fermentable dietary fiber, and remains of previously living things such as coral, shellfish, and dried fish;

2. Prevention of hypertension using the composition for lowering blood pressure according to claim 1, and prevention of arteriosclerosis, stones, etc. caused by calcium paradox, which is caused by calcium entering blood vessels, brain, cartilage, etc.

3. The composition for lowering blood pressure according to claim 1, which comprises water-soluble and fermentable dietary fiber, butyric acid-producing bacteria, and remains of previously living things such as coral, shellfish, and dried sardines, which are blended in a Vitamix blender and used as a water-based supplement, medicine, feed, or food.

4. The composition for lowering blood pressure according to claim 1, which comprises powdering water-soluble and fermentable dietary fiber, butyric acid-producing bacteria, and remains of previously living things such as coral, shellfish, and dried fish, and then grinding and mixing the powder in a grinder to produce tablets, supplements, medicines, feed, and food.

Images