Device for causing tears to be secreted

Abstract

To provide a device that enables efficient tear fluid collection with less stress on the subject.SOLUTION: An embodiment of the present disclosure provides a device for stimulating tear secretion including a container body including a rim capable of coming into close contact with a face in a region around an eye, the container body defining therein a gas-receiving space capable of being filled with gas generated by an eye irritant.SELECTED DRAWING: Figure 1

Description

[Technical field]

[0001] The present disclosure relates to a device for increasing tear production. [Background technology]

[0002] One method for collecting tears is, for example, to allow the tears to be absorbed by a test paper pressed against the surface of the eyeball.

[0003] It is necessary to collect tears efficiently. However, the method of pressing a test paper against the surface of the eyeball may cause pain and irritation to the eyeball. In addition, the secretion of tears cannot be freely controlled by the will of the subject from whom tears are to be collected, and it may take time to collect a sufficient amount of tears. For this reason, collecting tears may be a burden for the subject. It is necessary to collect tears efficiently while minimizing the burden on the subject. Summary of the Invention

[0004] Here, for example and without limitation, there is recognized a need to efficiently collect tears while minimizing the burden on the subject.

[0005] Some embodiments of the present disclosure provide a device for producing tears. In some embodiments, the device includes a container body. In some embodiments, the container body has a rim that can be fitted to the face around the periphery of the eye. In some embodiments, the container body defines a gas-supplied space. In some embodiments, the gas-supplied space can be filled therein with gas generated from an ocular irritant.

[0006] According to the above embodiment, for example, tear collection can be performed efficiently while minimizing the burden on the subject.

[0007] Further aspects and advantages of the present disclosure will become readily apparent to those skilled in the art from the following detailed description, in which only illustrative embodiments of the present disclosure are shown and described. As will be understood, the present disclosure is capable of other and different embodiments, and its several details are capable of modification in various obvious respects, without departing from the present disclosure. Accordingly, the drawings and description are to be regarded as illustrative in nature, and not as restrictive. [Brief description of the drawings]

[0008] [Figure 1] FIG. 1 is a schematic diagram illustrating a device according to an embodiment. [Diagram 2] FIG. 2 is a view of the device according to the embodiment of FIG. 1, seen from the opening side. [Diagram 3] FIG. 1 is a schematic diagram illustrating a device according to an embodiment. [Figure 4] FIG. 4 is a view of the device according to the embodiment of FIG. 3, seen from the opening side. [Diagram 5] FIG. 1 is a schematic diagram illustrating a device according to an embodiment. [Figure 6] FIG. 6 is a view of the device according to the embodiment of FIG. 5, seen from the opening side. [Figure 7] FIG. 1 is a schematic diagram illustrating a device according to an embodiment. [Figure 8] FIG. 8 is a view of the device according to the embodiment of FIG. 7, seen from the opening side. [Figure 9] FIG. 1 is a schematic diagram illustrating a device according to an embodiment. [Figure 10] 10 is a view of the device according to the embodiment of FIG. 9 as seen from the opening side. [Figure 11] FIG. 1 is a schematic diagram illustrating a device according to an embodiment. [Figure 12] FIG. 1 is a schematic diagram illustrating a device according to an embodiment. [Figure 13] FIG. 1 is a schematic diagram illustrating a device according to an embodiment. [Figure 14] FIG. 1 is a schematic diagram illustrating a device according to an embodiment. [Figure 15]FIG. 1 is a schematic diagram illustrating a device according to an embodiment. [Figure 16] FIG. 1 is a schematic diagram illustrating a device according to an embodiment. [Figure 17] FIG. 1 is a schematic diagram illustrating a device according to an embodiment. [Figure 18] FIG. 1 is a schematic diagram illustrating a device according to an embodiment. [Figure 19] FIG. 1 is a schematic diagram illustrating a device according to an embodiment. [Figure 20] FIG. 1 is a schematic diagram illustrating a device according to an embodiment. [Figure 21] FIG. 1 is a schematic diagram illustrating a device according to an embodiment. [Figure 22] FIG. 1 is a schematic diagram illustrating a device according to an embodiment. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0009] In some embodiments, the device secretes tears. The device may or may not collect the secreted tears.

[0010] In some embodiments, when the device does not collect the tears secreted by the device, the tears secreted by the device may be collected by another collecting means. The other collecting means may be, for example, a container that collects the tears that drop from the eye, or a member other than the container. The other collecting means may be, for example, a dropper that collects the tears by sucking the tears secreted from the eye, or a member other than the dropper.

[0011] In some embodiments, the tear fluid is secreted from the eye of a subject, which in some embodiments may include or be a human.

[0012] In some embodiments, the subject may include or be a non-human animal. The non-human animal may include or be a mammal. The non-human animal may be, for example, but not limited to, a working animal, a livestock animal, a pet animal, or a wild animal.

[0013] In some embodiments, the device comprises a reservoir body. In some embodiments, the reservoir body has a rim that can be fitted to the face at the periphery of the eye. In some embodiments, when tearing, the reservoir body has a rim that fits to the face at the periphery of the subject's eye.

[0014] The term "eye periphery" as used herein generally refers to a facial area located at the periphery of the eye. In some embodiments, the eye periphery may include, for example, one or more of the following: an area on the nasal side of the inner corner of the eye, an area on the temporal side of the outer corner of the eye, the upper eyelid, an area above the upper eyelid, the lower eyelid, and an area below the lower eyelid. In some embodiments, the face with which the edge can be in close contact may include an area of ​​the face below the subject's eyes in the orientation of the head when the subject is causing tears to be secreted from the eyes, or may be an area of ​​the face below the subject's eyes.

[0015] In some embodiments, the container body defines a gas-supplied space. In some embodiments, the device may include a gas-supplied space formed within the container body and into which gas generated from the ocular irritant is supplied.

[0016] As used herein, the term "gas-supplied space" generally refers to a space that can be filled with gas generated from an ocular irritant.

[0017] In some embodiments, the eye irritant may be one that generates a gas that irritates the eye and causes the eye to produce tears. In some embodiments, the eye irritant may include one of the substances that react to generate its component, or may be one of the substances that react to generate its component.

[0018] In some embodiments, the active ingredient of the ocular irritant may include or may be a lachrymatory ingredient or factor. In some embodiments, the ocular irritant may include or may be a part (one or more) of a plurality of substances necessary to produce a lachrymatory substance.

[0019] In some embodiments, the active ingredient of the ocular irritant may include a naturally derived substance, or may be a naturally derived substance. In some embodiments, the active ingredient of the ocular irritant may include a substance extracted from a plant of the Allium genus, or may be a substance extracted from a plant of the Allium genus. The Allium genus plant may be, for example, but not limited to, onion (Allium cepa), long leek (Allium fistulosum), garlic (Allium sativum), Sicilian garlic (Allium siculum), etc., or may include one or more thereof.

[0020] In some embodiments, the active ingredient of the eye irritant may include an artificially synthesized substance, and may be an artificially synthesized substance. In some embodiments, the eye irritant may include a chemical substance, and may be a chemical substance. In some embodiments, the eye irritant may include a lachrymatory gas, a lachrymatory agent, and may be a lachrymatory gas, a lachrymatory agent. In some embodiments, the eye irritant may be volatile. In some embodiments, the eye irritant may include an ingredient that irritates the eyes, and may be an ingredient that irritates the eyes. In some embodiments, the eye irritant may include benzyl bromide (benzyl bromide, α-bromotoluene, bromomethylbenzene). In some embodiments, the eye irritant may be benzyl chloride (α-chlorotoluene, chloromethylbenzene), and may include one or more thereof.

[0021] In some embodiments, the active ingredient of the eye irritant may include a compound having a structure called Thioalkanal S-Oxide at the end of the alkyl chain, or an analogous compound thereof, or may be the above-mentioned compound or an analogous compound thereof. In some embodiments, the active ingredient of the eye irritant may be a compound represented by R-CH=SO. It may include, for example, but not limited to, thioethanal S-oxide (R=C1), thiopropanal S-oxide (R=C2), thiobutanal S-oxide (R=C3), and thiohexanal S-oxide (R=C4).

[0022] In some embodiments, the ocular irritant may include syn-propanethial-S-oxide (also referred to as CHOS, Thiopropanal S-Oxide, 1-Sulfinylpropane) or may be syn-propanethial-S-oxide. In some embodiments, the ocular irritant may include a substance that synthesizes syn-propanethial-S-oxide or may be a substance that synthesizes syn-propanethial-S-oxide. In some embodiments, the ocular irritant may react with a substance to generate syn-propanethial-S-oxide during use.

[0023] In some embodiments, for example, an enzyme such as allinase (dry and supported on cellulose) may be used to degrade a sulfoxide amino acid (substrate) to generate sulfenic acid. In some embodiments, lachrymatory factor synthase (LFS) may be used to convert the resulting 1-propenesulfenic acid to syn-propanethial-S-oxide. In some embodiments, allinase and LFS may be placed in a container. In some embodiments, these enzymes may be supported on a support material in a dry state and placed in the container.

[0024] In some embodiments, for example, one or more of PRENCSO (trans-1-propenyl-L-cysteine ​​sulfoxide), allinase, and LFS may be used to generate syn-propanethial-S-oxide. In some embodiments, for example, one or more of PRENCSO, allinase, and LFS may be supported inside a container, and the remainder may be reacted with them during use.

[0025] In some embodiments, for example, the active ingredient of the ocular irritant may include syn-butanethial S-Oxide, C4H8OS, or may be syn-butanethial S-Oxide.

[0026] In some embodiments, for example, the eye irritant may be any of various other tear gases. The tear gas may be used as long as safety permits. For example, the tear gas may be diluted. For example, the tear gas may be modified to increase safety. The tear gas may be, for example, but not limited to, an emetic such as Adamsite; a sneezing agent such as diphenylcyanoarsine (DC) or diphenylchloroarsine (DA); or a lachrymator such as bromobenzyl cyanide, chloroacetophenone, chlorobenzylidene malononitrile, or dibenzo-1,4-oxazepine, or may include one or more of them. The tear gas may be a pepper spray or may include its main component capsaicin (also called oleoresin capsicum, OC agent).

[0027] In some embodiments, the device may further include a fibrous tissue that carries the eye irritant and is disposed in the irritant placement portion. The fibrous tissue that carries the eye irritant may be, for example, but is not limited to, cellulose, gauze, nonwoven fabric, or sponge. The fibrous tissue that carries the eye irritant may take various shapes. For example, the shape may include, but is not limited to, a circular shape, a sheet shape, a string shape, a circular shape, or a spherical shape. As an example, the fibrous tissue may be formed in a cotton-like or fluffy shape. This, for example, increases the substantial surface area, and improves the volatilization efficiency of the lachrymation component and the penetration efficiency of the substrate liquid. In some embodiments, the eye irritant may be in a liquid form and sealed in the bag. In some embodiments, the device may not include a fibrous tissue that carries the eye irritant, and the components of the eye irritant may be carried in a dry state in the container body. In some embodiments, the eye irritant may be prepared in a solid form, for example, as a tablet or powder. For example, the eye irritant may be provided in a state mixed with an excipient.

[0028] In some embodiments, the eye irritant may include at least a portion of the enzyme and the substrate that react to generate a gas, or may be the enzyme and the substrate that react to generate a gas. In some embodiments, the enzyme may be arranged in the irritant arrangement in a dry state, and the substrate may be added to the enzyme in a solution state. In some embodiments, the enzyme may be allinase and lachrymation factor synthase (LFS). In some embodiments, the substrate may be PRENCSO. In some embodiments, a solution of the substrate PRENCSO may be dropped onto the enzyme during use. These may react to generate the active ingredient of the eye irritant.

[0029] In some embodiments, the container body may be cup-shaped with an opening, or may not be cup-shaped with an opening. In some embodiments, when the container body is not cup-shaped, the container body may be, for example, plate-shaped, dish-shaped with a concave surface on the inside from the outer edge, cylindrical with a bottom, etc., as long as it can receive the tear fluid. In some embodiments, the container body may include a bottom disposed on the other side in the first direction, and a peripheral wall rising from the periphery of the bottom to one side in the first direction.

[0030] In some embodiments, the container body may have an opening in one direction in the first direction, or in a direction other than the first direction. As used herein, the term "first direction" generally refers to the opening direction of the container body.

[0031] In some embodiments, when the container body has an opening, the rim may be formed continuously around the entire circumference, or may be formed only on a part of the opening. In some embodiments, the container body may form a substantially closed space between the eye and the container body when worn with the rim in close contact with the face around the eye, or may not form a closed space. In some embodiments, a container body that does not form a substantially closed space between the eye and the container body may form a partially open space between the eye and the container body.

[0032] In some embodiments, the device may further include a stimulant placement portion that communicates with the gas-supplied space and in which an eye stimulant is placed, or may not include the stimulant placement portion. In some embodiments, the stimulant placement portion may be formed in at least a portion of the gas-supplied space, or may not be formed in at least a portion of the gas-supplied space. In some embodiments, the stimulant placement portion may be formed separately from the gas-supplied space. In some embodiments, the stimulant may be placed in a position closest to the iris or pupil of the user when the device is used. This is said to be the site on the eyeball that has the most tear-inducing effect, according to one theory. For example, the stimulant placement portion may be defined substantially at the center of the bottom of the container, or may be defined in the center or vicinity of the volume of the container.

[0033] In some embodiments, the inside of the container body may further include a tear storage section for collecting tears secreted from the eye, or may not include a tear storage section.

[0034] In some embodiments, the container body may include a partition wall that divides the inside of the container body into a gas supply portion and a tear fluid accommodating portion, or may not include a partition wall. In some embodiments, when a partition wall is not included, the gas supply portion and the tear fluid accommodating portion may be disposed inside the container body without being divided.

[0035] In some embodiments, when the gas supply portion and the tear accommodating portion are arranged without being partitioned inside the container body, the stimulant arranging portion may be formed on the bottom of the container body, or may be formed on a portion other than the bottom of the container body. In some embodiments, the stimulant arranging portion may be formed so as to be arranged on the bottom. In some embodiments, when the stimulant arranging portion is formed on the bottom of the container body, the bottom may be inclined toward the other side in the first direction from a bottom intermediate portion between a first end of the container body located on the outer corner of the eye and a second end located on the inner corner of the eye in a wearing state in which the edge is in close contact with the face of the peripheral part of the eye, toward the first end side and the second end side, or the bottom may not be inclined.

[0036] In some embodiments, the stimulant placement portion may be formed on the second end side of the bottom intermediate portion, or may not be formed on the second end side. In some embodiments, when the bottom portion includes a platform portion that rises from the periphery of the bottom portion toward the inside of the bottom portion on one side in the first direction, the stimulant placement portion may be formed on the platform portion, or may not be formed on the platform portion. In some embodiments, the bottom portion is detachable from the peripheral wall, and the stimulant placement portion may be disposed on the bottom portion, or may be disposed other than on the bottom portion.

[0037] In some embodiments, the stimulant placement portion may be formed on the inner circumferential surface of the peripheral wall, or may not be provided on the inner circumferential surface of the peripheral wall. In some embodiments, the stimulant placement portion may include a holder body that holds an ocular stimulant, and a connection member having one end connected to the holder body and the other end connected to the container body. In some embodiments, the container body includes a detachable member that is detachable from its opening, and the stimulant placement portion may be disposed on the surface of the detachable member on the side facing the inside of the container body when the detachable member is attached to the opening.

[0038] In various aspects, the bottom part may be configured to be detachable from the peripheral wall. For example, the bottom part and the peripheral wall may each have a magnet and be configured to be detachable. The manner of detachable connection between the bottom part and the peripheral wall includes, but is not limited to, a magnet, double-sided tape, Velcro, fitting, hooking, plugging (for example, sliding a part of the bottom part into a slit provided in the peripheral wall), etc. Other aspects may also be used.

[0039] In some embodiments, the partition wall is disposed between a first end located on the outer corner of the eye and a second end located on the inner corner of the eye when the container is worn with the edge in close contact with the face around the eye, and may divide the inside of the container body into a first compartment on the first end side and a second compartment on the second end side, and the partition wall may not divide the inside of the container body into a first compartment and a second compartment. In some embodiments, when the partition wall divides the inside of the container body into a first compartment and a second compartment, the first compartment may form a tear accommodating portion, and the second compartment may form a gas supplied space. In some embodiments, the first compartment may form a gas supplied space, and the second compartment may form a tear accommodating portion.

[0040] In some embodiments, the partition wall is disposed between an upper end of the container body located on the upper eyelid side and a lower end located on the lower eyelid side when the container body is worn with its edge in close contact with the face around the eye, and may partition the interior of the container body into an upper compartment on the upper end side and a lower compartment on the lower end side, or the partition wall may not partition the interior of the container body into an upper compartment and a lower compartment. In some embodiments, when the partition wall partitions the interior of the container body into an upper compartment and a lower compartment, the upper compartment may form the tear accommodating section, and the lower compartment may form the gas supplied space. In some embodiments, the upper compartment may form the gas supplied space, and the lower compartment may form the tear accommodating section.

[0041] In some embodiments, the entire circumference of the outer peripheral end of the partition wall is joined to the inner peripheral surface of the container body, forming an enclosed space between the partition wall and the inner peripheral surface of the container body, the enclosed space forming the stimulant placement portion, and the partition wall may have an air vent communicating with both sides thereof.

[0042] In some embodiments, the partition wall may be formed in a cylindrical shape rising from the bottom to one side in the first direction, and the stimulant placement portion may be positioned inside the cylindrical partition wall.

[0043] In some embodiments, the partition wall may be disposed at a middle position in the first direction of the peripheral wall in a plane direction intersecting the first direction, and may partially partition the internal space of the container body. In some embodiments, when the partition wall partially partitions the internal space of the container body, the stimulant disposing portion may be disposed on the bottom side in the first direction with respect to the partition wall, and the tear fluid accommodating portion may be formed on the opposite side of the bottom in the first direction with respect to the partition wall. In some embodiments, when the partition wall partially partitions the internal space of the container body, the stimulant disposing portion may be disposed on the opposite side of the bottom in the first direction with respect to the partition wall, and the tear fluid accommodating portion may be formed on the bottom side in the first direction with respect to the partition wall. In some embodiments, the partition wall is formed to have a communication portion that communicates the internal space of the container body between the bottom side and the opposite side in the first direction, and the communication portion may be disposed on the inner corner side of the eye when the edge of the container body is attached in close contact with the face of the peripheral part of the eye. In some embodiments, the communication portion may be disposed on the outer corner side of the eye when the edge of the container body is attached in close contact with the face of the peripheral part of the eye. In some embodiments, the partition wall may be inclined toward the bottom side in the first direction from the communication part toward the peripheral wall, or may not be inclined. In some embodiments, the partition wall may be inclined toward the opposite side to the bottom side in the first direction from the communication part toward the peripheral wall.

[0044] In some embodiments, the device may or may not include a tear container that is provided integrally with the container body and collects the tear contained in the tear container. In some embodiments, the tear container may or may not be formed in a bottomed cylindrical shape extending outward from the opening of the container body. In some embodiments, when the tear container is not formed in a bottomed cylindrical shape, the tear container may be, for example, but not limited to, a hollow sphere or a hollow box having an opening communicating with the container body. In some embodiments, the tear container may not be provided integrally with the container body. In some embodiments, the tear container may be provided separately from the container body. In some embodiments, when the tear container is provided separately from the container body, the device may further include a connection tube that connects the container body and the tear solution. In some embodiments, the tear container may be configured so that the tear solution is transferred from the container body to the tear container provided separately from the container body.

[0045] In some embodiments, the tear container provided integrally with the container body may be disposed on the outer corner of the eye relative to the container body in a state in which the edge of the container body is in close contact with the face of the peripheral portion of the eye, and the tear container may have a container opening that opens on the inner corner of the eye. In some embodiments, the tear container provided integrally with the container body may be disposed at a position other than the outer corner of the eye relative to the container body in a state in which the edge of the container body is in close contact with the face of the peripheral portion of the eye. In some embodiments, the tear container may have a container opening that opens in a direction other than the inner corner of the eye. In some embodiments, the tear container may have a container opening that opens inward of the container body.

[0046] In some embodiments, the container body may have an access opening that allows access to the inside of the container body from the outside when the container body is worn with its rim tightly against the face around the eye, for example, but not limited to, for use in collecting tears or injecting eye irritants.

[0047] In some embodiments, at least a part or the whole of the container body may be formed of a transparent material that allows the inside to be optically confirmed from the outside of the container body. The transparent material that allows the inside to be optically confirmed from the outside of the container body may be, for example, but not limited to, a resin-based material or a glass-based material. In some embodiments, the transparent material that allows the inside to be optically confirmed from the outside of the container body may have a transparency that allows the amount of tear fluid accumulated inside the container body to be confirmed visually or with a camera from outside the container body. In some embodiments, a camera may be disposed inside the container body. In some aspects, the required light may be incident from the outside of the container to the inside. In some aspects, the required light may be emitted inside the container body.

[0048] In some embodiments, the device may include two container bodies. In some embodiments, the device may include a connector that connects the ends of the two container bodies on the inner corner side, which are located on the inner corner side when the two container bodies are worn with their edges in close contact with the face of the peripheral area of ​​the eye. In some embodiments, the device may further include a fastener that can fasten the container body to the subject's head so that the edges are in close contact with the face of the peripheral area of ​​the eye. In some embodiments, each of the two container bodies may further include a fastener that is provided at the outer corner side end that is located on the outer corner side when the two container bodies are worn with their edges in close contact with the face of the peripheral area of ​​the eye, and can fasten the container body to the subject's head. The fastener may be formed, for example and without limitation, in the shape of a vine for glasses to be hung on the subject's ears, or in the shape of a band to be hung around the back of the subject's head.

[0049] 1 and 2 show a device 100A according to an embodiment. The device 100A shown in Fig. 1 and Fig. 2 includes a container body 10A and a partition wall 20A.

[0050] The container body 10A includes a bottom 11 and a peripheral wall 12. The container body 10A has an opening 13 that opens toward one side Da1 in a first direction Da. The container body 10A is formed from a material having transparency that allows the inside of the container body 10A to be optically confirmed from the outside, such as a transparent or translucent resin material.

[0051] The bottom 11 is disposed on the other side Da2 of the first direction Da in the container body 10A. The first direction Da is the direction in which the opening 13 opens. The first direction Da is the direction connecting the opening 13 and the bottom 11. The bottom 11 is, for example, plate-shaped and disposed along a plane intersecting (substantially perpendicular to) the first direction Da. The bottom 11 is formed in an elliptical shape when viewed from the first direction Da. The elliptical bottom 11 has a second direction Db perpendicular to the first direction Da as its major axis direction. The bottom 11 has a third direction Dc perpendicular to the first direction Da and the second direction Db as its minor axis direction. The bottom 11 may be oval, circular, polygonal, or the like when viewed from the first direction Da.

[0052] The peripheral wall 12 is formed so as to rise from the peripheral direction of the bottom 11 to one side Da1 in the first direction Da. The peripheral wall 12 is formed in a cylindrical shape extending in the first direction Da. The peripheral wall 12 is formed so that the inner diameter gradually increases from the bottom 11 to the other side Da2 in the first direction Da toward the one side Da1. In the peripheral wall 12, the peripheral edge 125 of the end portion of the one side Da1 in the first direction Da is greatly expanded in diameter in a flare shape (morning glory shape) toward the one side Da1 in the first direction Da. The peripheral edge 125 of the peripheral wall 12 is formed with a rim 15. The rim 15 is formed so that it can be closely attached to the face at the rim of the subject's eye when the device 100A is used. The container body 10A forms a substantially closed space between the eye 1000 and the container body 10A in a wearing state in which the rim 15 is closely attached to the face of the rim of the eye 1000. The edge 15 does not have to completely adhere to the face at the periphery of the eye 1000 to form a completely closed space. As long as tears can be collected by the container body 10A, there may be some gap between the edge 15 and the face at the periphery of the eye 1000.

[0053] As shown in FIG. 2, the container body 10A is used with the edge 15 in close contact with the face at the periphery of the eye 1000 of the subject. The second direction Db of the container body 10A is substantially aligned with a direction connecting the inner corner 1001 side and the outer corner 1002 side of the eye 1000 of the subject. The container body 10A has a first end 101 and a second end 102. The first end 101 is located on the inner corner 1001 side when the container body 10A is worn with the edge 15 in close contact with the face at the periphery of the eye 1000. The second end 102 is located on the outer corner 1002 side when the container body 10A is worn with the edge 15 in close contact with the face at the periphery of the eye 1000.

[0054] The partition wall 20A divides the inside of the container body 10A into a plurality of spaces. The partition wall 20A is disposed between the first end 101 and the second end 102. The partition wall 20A is disposed in the middle between the first end 101 and the second end 102 in the second direction Db. The partition wall 20A may be disposed in a position biased toward the first end 101 side or the second end 102 side from the middle between the first end 101 and the second end 102 in the second direction Db. The partition wall 20A is disposed in a plane direction substantially perpendicular to the second direction Db. The outer edge of the partition wall 20A is joined to the bottom 11 and the peripheral wall 12 of the container body 10A. The partition wall 20A divides the inside of the container body 10A into a first section 111 on the first end 101 side and a second section 112 on the second end 102 side.

[0055] A gas supply space 70A and a tear accommodating portion 80A are disposed within container body 10A. Partition wall 20A divides the interior of container body 10A into gas supply space 70A and tear accommodating portion 80A. In the present disclosure, first partition 111 forms gas supply space 70A. Second partition 112 forms tear accommodating portion 80A.

[0056] The gas supply space 70A is defined by the container body 10A. A stimulant arranging section 60A is arranged within the container body 10A. An eye stimulant 90 is arranged in the stimulant arranging section 60A. In the present disclosure, the eye stimulant 90 is arranged within the gas supply space 70A. As a result, the stimulant arranging section 60A is formed in at least a part of the gas supply space 70A. Therefore, the stimulant arranging section 60A communicates with the gas supply space 70A.

[0057] The eye irritant 90 generates a gas that stimulates the eyes and causes the eyes to secrete tears. The eye irritant 90 generates a component that causes the eyes to secrete tears through a reaction.

[0058] In an embodiment of the present disclosure, the active ingredient of the eye irritant 90 includes a substance extracted from a plant of the Allium genus, which is a naturally occurring substance. In an embodiment of the present disclosure, the eye irritant 90 includes, for example, allinase, which is a type of enzyme, and LFS. The eye irritant 90 is supported in a dry state on, for example, cellulose as a fibrous tissue 91.

[0059] In an embodiment of the present disclosure, the ocular stimulant 90 is in a dry state with PRENCSO as a substrate supported on a fibrous tissue 91.

[0060] The enzyme of the eye irritant 90 reacts with the substrate solution (aqueous solution) to generate syn-propanethial-S-oxide. The gas containing the generated syn-propanethial-S-oxide irritates the eye and induces tear production.

[0061] In some embodiments, a mixture of the substrate and the enzyme may be provided and water may be added thereto.In some embodiments, the ocular irritant 90 may include an enzyme and a substrate.

[0062] To collect tears from the subject's eye using the device 100A, the eye irritant 90 is placed in the irritant placement section 60A of the container body 10A. The eye irritant 90 may be fixed in advance to the inner peripheral surface of the container body 10A, for example, by adhesive or the like. When a substrate solution or water is dropped onto the eye irritant 90 in the container body 10A, the gas supply space 70A is filled with gas generated from the eye irritant 90. With the opening 13 of the container body 10A facing the subject's eye 1000, the edge 15 is brought into close contact with the face of the periphery of the eye 1000. The subject tilts his / her head so that the outer corner 1002 side of the eye 1000 against which the container body 10A is pressed is downward relative to the inner corner 1001.

[0063] The gas in the gas supply space 70A stimulates the eye 1000 by contacting the eyeball of the subject. This causes tears to be secreted from the eye 1000. The secreted tears flow out of the eye 1000 from the lower outer corner 1002 side. The flowed tears flow into the tear storage section 80A of the container body 10A. In this way, the tears are collected by the container body 10A. The partition wall 20A in the container body 10A prevents the collected tears from flowing toward the stimulant placement section 60A side where the eye stimulant 90 is placed.

[0064] The device 100A described above can collect tears without directly pressing the test paper against the subject's eyeball. The device 100A stimulates the eye 1000 with the gas generated from the eye stimulant 90 to secrete tears. This allows the tears to be secreted efficiently. The device 100A brings the edge 15 of the container body 10A into close contact with the face at the periphery of the eye. This prevents the gas generated from the eye stimulant 90 from diffusing to the surroundings. Therefore, the gas generated from the eye stimulant 90 can efficiently stimulate the eye 1000. The tears secreted from the eye 1000 are prevented from leaking out of the container body 10A. Therefore, the device 100A allows the collection of tears to be performed efficiently while reducing the burden on the subject.

[0065] Figures 3 and 4 show a device 100B according to an embodiment. In the following description, components common to the device 100A shown in Figures 1 and 2 are denoted by the same reference numerals as in Figures 1 and 2, and description thereof will be omitted.

[0066] The device 100B shown in FIGS. 3 and 4 includes a container body 10B and a partition wall 20B.

[0067] The container body 10B has a bottom 11, a peripheral wall 12, an opening 13, and a rim 15.

[0068] The partition wall 20B divides the inside of the container body 10B into a plurality of spaces. The partition wall 20B is disposed between the upper end 103 and the lower end 104. The partition wall 20B is disposed in the middle between the upper end 103 and the lower end 104 in the third direction Dc. The partition wall 20B may be disposed in a position biased toward the upper end 103 side or the lower end 104 side from the middle between the upper end 103 and the lower end 104 in the third direction Dc. The partition wall 20B is disposed in a plane direction substantially perpendicular to the third direction Dc. The outer edge of the partition wall 20B is joined to the bottom 11 and the peripheral wall 12 of the container body 10B. The partition wall 20B divides the inside of the container body 10B into an upper section 121 on the upper end 103 side and a lower section 122 on the lower end 104 side.

[0069] A gas supply space 70B and a tear fluid containing portion 80B are disposed within container body 10B. Partition wall 20B divides the interior of container body 10B into gas supply space 70B and tear fluid containing portion 80B. In the present disclosure, upper section 121 forms gas supply space 70B. Lower section 122 forms tear fluid containing portion 80B.

[0070] The gas supply space 70B is defined by the container body 10B. A stimulant arranging section 60B is arranged within the container body 10B. An eye stimulant 90 is arranged in the stimulant arranging section 60B. In the present disclosure, the eye stimulant 90 is arranged within the gas supply space 70B. As a result, the stimulant arranging section 60B is formed in at least a portion of the gas supply space 70B. Therefore, the stimulant arranging section 60B communicates with the gas supply space 70B.

[0071] To collect tears from the subject's eye 1000 using the device 100B, the container body 10B is placed in a worn state with the rim 15 in close contact with the face around the periphery of the eye 1000. The upper end 103 is located on the upper eyelid 1003 side. The lower end 104 is located on the lower eyelid 1004 side.

[0072] The gas in the gas supply space 70B generated from the eye stimulant 90 stimulates the eye 1000 of the subject. This causes tears to be secreted from the eye 1000. The secreted tears flow out of the eye 1000. The flowed out tears flow into the tear storage section 80B of the container body 10B. In this way, the tears are collected by the container body 10B. The partition wall 20B in the container body 10B prevents the collected tears from flowing toward the stimulant placement section 60B where the eye stimulant 90 is placed.

[0073] With the device 100B as described above, tear collection can be performed efficiently while minimizing the burden on the subject.

[0074] Figures 5 and 6 show a device 100C according to an embodiment. In the following description, components common to the device 100A shown in Figures 1 and 2 are denoted by the same reference numerals as in Figures 1 and 2, and description thereof will be omitted.

[0075] The device 100C shown in FIGS. 5 and 6 includes a container body 10C and a partition wall 20C.

[0076] The container body 10C has a bottom 11, a peripheral wall 12, an opening 13, and a rim 15.

[0077] The partition wall 20C divides the inside of the container body 10C into a plurality of spaces. The partition wall 20C is disposed inward of the container body 10C relative to the inner peripheral surface of the container body 10C. The partition wall 20C has an outer peripheral end 21 joined to the container body 10C at the entire circumference. The bottom outer peripheral end 211 of the partition wall 20C is curved in an arc shape when viewed from the first direction Da. The bottom outer peripheral end 211 is joined to the bottom 11 at a position away from the inner peripheral surface 114 of the peripheral wall 12 on the first end 101 side to the second side Db2 in the second direction Db. In the partition wall 20C, the side outer peripheral ends 212 located on both sides of the peripheral wall 12 in the circumferential direction are joined to the inner peripheral surface of the peripheral wall 12 on the first end 101 side. The partition wall 20C is formed so that the width in the circumferential direction gradually decreases from the other side Da2 to the one side Da1 in the first direction Da. An enclosed space 131 is formed between the partition wall 20C and the peripheral wall inner surface 114 on the first end 101 side of the peripheral wall 12. The partition wall 20C divides the inside of the container body 10C into the enclosed space 131 and an open space 132 other than the enclosed space 131. The open space 132 is opened by the opening 13 to one side Da1 in the first direction Da.

[0078] The partition wall 20C has vent holes 220 communicating with both sides thereof. For example, two vent holes 220 are arranged on both sides in the circumferential direction of the peripheral wall 12 in the partition wall 20C. The number of vent holes 220 is not limited to two. The number of vent holes 220 may be one, or three or more. The position of the vent hole 220 is not specifically limited as long as it communicates with the gas supply space 70C in the container body 10C.

[0079] A stimulant-disposing portion 60C is disposed within the container body 10C. An eye stimulant 90 is disposed in the stimulant-disposing portion 60C. The stimulant-disposing portion 60C is formed in the sealed space 131.

[0080] A gas supply space 70C is defined within the container body 10C. In the embodiment of the present disclosure, the open space 132 forms the gas supply space 70C. The gas generated from the eye irritant 90 arranged in the irritant arrangement portion 60C of the sealed space 131 is supplied to the gas supply space 70C through the ventilation port 220.

[0081] To collect tears from the subject's eye 1000 using the device 100C, the container body 10C is attached with the edge 15 in close contact with the face around the periphery of the eye 1000. The subject tilts his / her head so that the outer corner 1002 side of the eye 1000 against which the container body 10C is pressed is downward relative to the inner corner 1001.

[0082] The gas generated from the eye stimulant 90 is supplied to the gas supply space 70C, thereby stimulating the subject's eye 1000. As a result, tears secreted from the eye 1000 flow out of the eye 1000 from the lower outer corner 1002 side. The flowing tears flow into the tear storage section 80C of the container body 10C. In this way, the tears are collected by the container body 10C. The partition wall 20C in the container body 10C prevents the collected tears from flowing toward the stimulant placement section 60C where the eye stimulant 90 is placed.

[0083] With the device 100C as described above, tear collection can be performed efficiently while minimizing the burden on the subject.

[0084] Figures 7 and 8 show a device 100D according to an embodiment. In the following description, components common to the device 100A shown in Figures 1 and 2 are denoted by the same reference numerals as in Figures 1 and 2, and description thereof will be omitted.

[0085] A device 100D shown in FIGS. 7 and 8 includes a container body 10D and a partition wall 20D.

[0086] The container body 10D has a bottom 11, a peripheral wall 12, an opening 13, and a rim 15.

[0087] The partition wall 20D divides the inside of the container body 10D into a plurality of spaces. The partition wall 20D is formed on the bottom 11. The partition wall 20D is formed in a cylindrical shape. The partition wall 20D extends from the bottom 11 to rise toward one side Da1 in the first direction Da. The height of the partition wall 20D from the bottom 11 is lower than the edge 15 of the container body 10D. The partition wall 20D has a circular cross-sectional shape as viewed from the first direction Da. The cross-sectional shape of the partition wall 20D may be an ellipse, a polygonal shape, or the like. The partition wall 20D is disposed in the center of the bottom 11 as viewed from the first direction Da. The partition wall 20D divides the inside of the container body 10D into an inner section 141 and an outer section 142. The inner section 141 is formed radially inward of the partition wall 20D. The outer section 142 is formed radially outward of the partition wall 20D.

[0088] A gas supply space 70D and a tear fluid containing portion 80D are arranged within the container body 10D. A partition wall 20D partitions the interior of the container body 10D into a stimulant arranging portion 60D and a tear fluid containing portion 80D. In the present disclosure, the inner compartment 141 forms the stimulant arranging portion 60D. The outer compartment 142 forms the tear fluid containing portion 80D.

[0089] The gas supply space 70D is defined by the container body 10D. The gas generated from the eye stimulant 90 arranged in the stimulant arrangement portion 60D can fill (saturate) the entire inside of the container body 10D. In an embodiment of the present disclosure, the gas supply space 70D is the entire inside of the container body 10D.

[0090] To collect tears from the subject's eye 1000 using the device 100D, the container body 10D is placed in a worn state with the rim 15 in intimate contact with the face around the periphery of the eye 1000.

[0091] The gas in the gas supply space 70D generated from the eye stimulant 90 stimulates the eye 1000 of the subject. This causes tears to be secreted from the eye 1000. The secreted tears flow out of the eye 1000. The flowed out tears flow into the tear storage section 80D of the container body 10D. In this way, the tears are collected by the container body 10D. The partition wall 20D in the container body 10D prevents the collected tears from flowing toward the stimulant placement section 60D where the eye stimulant 90 is placed.

[0092] With the device 100D as described above, tear collection can be performed efficiently while minimizing the burden on the subject.

[0093] Figures 9 and 10 show a device 100E according to an embodiment. In the following description, components common to the device 100A shown in Figures 1 and 2 are denoted by the same reference numerals as in Figures 1 and 2, and description thereof will be omitted.

[0094] A device 100E shown in FIGS. 9 and 10 includes a container body 10E and a partition wall 20E.

[0095] The container body 10E has a bottom 11, a peripheral wall 12, an opening 13, and a rim 15.

[0096] The partition wall 20E divides the inside of the container body 10E into a plurality of spaces. The partition wall 20E is disposed at a middle position in the first direction Da in the peripheral wall 12. The partition wall 20E is disposed away from the bottom 11 on one side Da1 in the first direction Da. The partition wall 20E is disposed in a planar direction intersecting the first direction Da. The partition wall 20E is disposed on the first side Db1 in the second direction Db, with a communication portion 230 spaced from the peripheral wall inner surface 114 on the first end 101 side.

[0097] The partition wall 20E is inclined toward the other side Da2 of the first direction Da from the first end 101 side toward the second end 102 side of the container body 10E with respect to a plane direction perpendicular to the first direction Da. The partition wall 20E is formed so as to partially block the internal space of the container body 10E when viewed from the first direction Da.

[0098] The partition wall 20E partially divides the space inside the container body 10E into a bottom side space 151 and an opening side space 152. The bottom side space 151 is formed on the other side Da2 (bottom 11 side) in the first direction Da within the container body 10E across the partition wall 20E. The opening side space 152 is formed on one side Da1 (opening 13 side) in the first direction Da across the partition wall 20E. The bottom side space 151 and the opening side space 152 communicate with each other via a communication portion 230.

[0099] A stimulant arranging section 60E and a tear fluid containing section 80E are arranged within the container body 10E. A partition wall 20E partially divides the interior of the container body 10E into the stimulant arranging section 60E and the tear fluid containing section 80E. In the present disclosure, the bottom side space 151 forms the stimulant arranging section 60E. The opening side space 152 forms the tear fluid containing section 80E.

[0100] The gas supply space 70E is defined by the container body 10E. Gas generated from the eye stimulant 90 arranged in the stimulant arrangement portion 60E flows from the bottom side space 151 through the communication portion 230 into the opening side space 152. The gas generated from the eye stimulant 90 can fill (saturate) the entire inside of the container body 10E. In the embodiment of the present disclosure, the gas supply space 70E is the entire inside of the container body 10E.

[0101] To collect tears from the subject's eye 1000 using the device 100E, the container body 10E is attached with the edge 15 in close contact with the face around the periphery of the eye 1000. The subject tilts his / her head so that the outer corner 1002 side of the eye 1000 against which the container body 10E is pressed is downward relative to the inner corner 1001.

[0102] The gas in the gas supply space 70E generated from the eye stimulant 90 stimulates the eye 1000 of the subject. This causes tears to be secreted from the eye 1000. The secreted tears flow out from the eye 1000. The flowed out tears flow into the tear storage section 80E of the container body 10E. In this way, the tears are collected by the container body 10E. The partition wall 20E in the container body 10E prevents the collected tears from flowing to the stimulant placement section 60E side where the eye stimulant 90 is placed. The partition wall 20E is inclined toward the other side Da2 from the first end 101 side toward the second end 102 side of the container body 10E with respect to the plane direction perpendicular to the first direction Da. This prevents the tears from flowing to the communication section 230 side.

[0103] With the device 100E as described above, tear collection can be performed efficiently while minimizing the burden on the subject.

[0104] Figure 11 shows a device 100F according to an embodiment. In the following description, components common to the device 100A shown in Figures 1 and 2 are given the same reference numerals as in Figures 1 and 2, and description thereof will be omitted.

[0105] 11 includes a container body 10F. The container body 10F has a bottom 11, a peripheral wall 12, an opening 13, and a rim 15. A stimulant disposing section 60F, a gas supply space 70F, and a tear fluid containing section 80F are disposed within the container body 10F.

[0106] The stimulant arranging section 60F is disposed on the bottom 11. The stimulant arranging section 60F may be disposed on the bottom 11 at a position biased toward the first side Db1 in the second direction Db. The stimulant arranging section 60F may, for example, simply place the eye stimulant 90 on the bottom 11. The stimulant arranging section 60F may, for example, fix the eye stimulant 90 to the bottom 11 with an adhesive or the like.

[0107] The gas supply space 70F is defined by the container body 10F. The gas generated from the eye stimulant 90 arranged in the stimulant arrangement portion 60F can fill (permeate) the entire inside of the container body 10F. In an embodiment of the present disclosure, the gas supply space 70F is the entire inside of the container body 10F.

[0108] The tear fluid storage section 80F is formed inside the container body 10F. To collect tear fluid from the subject's eye using the device 100F, the container body 10F is worn with the edge 15 in close contact with the face around the periphery of the eye 1000. The subject tilts his / her head so that the outer corner 1002 side of the eye 1000 against which the container body 10F is pressed is downward relative to the inner corner 1001. The tear fluid storage section 80F is formed in the container body 10F in an area on the second side Db2 side in the second direction Db, which is the outer corner 1002 side of the eye.

[0109] The gas generated from the eye stimulant 90 is supplied to the gas supply space 70F, thereby stimulating the subject's eye 1000. As a result, tears secreted from the eye 1000 flow out of the eye 1000 from the lower outer corner 1002 side. The flowing tears flow into the tear storage portion 80F of the container body 10F. In this way, the tears are collected by the container body 10F.

[0110] With the device 100F as described above, tear collection can be performed efficiently while minimizing the burden on the subject.

[0111] Fig. 12 shows a device 100G according to an embodiment. In the following description, components common to the device 100A shown in Fig. 1 and Fig. 2 are denoted by the same reference numerals as in Fig. 1 and Fig. 2, and description thereof will be omitted.

[0112] 12 includes a container body 10G. The container body 10G has a bottom 11G, a peripheral wall 12, an opening 13, and a rim 15.

[0113] The bottom 11G has a bottom intermediate portion 115 between the first end 101 and the second end 102 raised in the second direction Db. The bottom 11G is inclined from the bottom intermediate portion 115 toward the first end 101 side Da1 in the second direction Db and toward the second end 102 side Da2 in the second direction Db toward the other side Da2 (bottom 11 side) in the first direction Da.

[0114] A stimulant arranging section 60G, a gas supplied space 70G, and a tear containing section 80G are arranged within the container body 10G.

[0115] The stimulant placement portion 60G is disposed on the bottom portion 11G. The stimulant placement portion 60G is disposed on the bottom portion 11G on the first side Db1 in the second direction Db relative to the raised bottom intermediate portion 115.

[0116] The gas supply space 70G is defined by the container body 10G. The gas generated from the eye stimulant 90 arranged in the stimulant arrangement portion 60G can fill (permeate) the entire inside of the container body 10G. In an embodiment of the present disclosure, the gas supply space 70G is the entire inside of the container body 10G.

[0117] The tear fluid storage section 80G is formed inside the container body 10G. To collect tear fluid from the subject's eye 1000 using the device 100G, the container body 10G is worn with the edge 15 in close contact with the face of the periphery of the eye 1000. The subject tilts his / her head so that the outer corner 1002 side of the eye 1000 against which the container body 10G is pressed is lower than the inner corner 1001. The tear fluid storage section 80G is disposed on the second side Db2 in the container body 10G in the second direction Db than the raised bottom intermediate portion 115.

[0118] The gas generated from the eye stimulant 90 is supplied to the gas supply space 70G, thereby stimulating the eye 1000 of the subject. As a result, tears secreted from the eye 1000 flow out of the eye 1000 from the lower outer corner 1002 side. The flowing tears flow into the tear storage section 80G of the container body 10G. In this way, the tears are collected by the container body 10G. With the device 100G as described above, it is possible to efficiently collect tears while minimizing the burden on the subject.

[0119] Figure 13 shows a device 100H according to an embodiment. In the following description, components common to the device 100A shown in Figures 1 and 2 are given the same reference numerals as in Figures 1 and 2, and description thereof will be omitted. 13 includes a container body 10H. The container body 10H has a bottom 11H, a peripheral wall 12, an opening 13, and a rim 15. A stimulant disposing section 60H, a gas supply space 70H, and a tear fluid containing section 80H are disposed within the container body 10H.

[0120] The bottom 11H is detachable from the peripheral wall 12. The bottom 11H may be configured to be openable and closable with respect to the peripheral wall 12. The stimulant arranging section 60H is arranged on the bottom 11H. The stimulant arranging section 60H may be, for example, a section in which the eye stimulant 90 is simply placed on the bottom 11H. The stimulant arranging section 60H may be, for example, a section in which the eye stimulant 90 is fixed to the bottom 11H with an adhesive or the like.

[0121] The gas supply space 70H is defined by the container body 10H. The gas generated from the eye stimulant 90 arranged in the stimulant arrangement portion 60H can fill (permeate) the entire inside of the container body 10H. In an embodiment of the present disclosure, the gas supply space 70H is the entire inside of the container body 10H.

[0122] The tear storage section 80H is formed inside the container body 10H. To collect tear from the subject's eye 1000 using the device 100H, the container body 10H is worn with the edge 15 in close contact with the face of the periphery of the eye 1000. The subject tilts his / her head so that the outer corner 1002 side of the eye 1000 against which the container body 10H is pressed is downward relative to the inner corner 1001. The tear storage section 80H is formed in the container body 10H in an area on the second side Db2 side in the second direction Db, which is the outer corner 1002 side of the eye.

[0123] To collect tears from the subject's eye 1000 using the device 100H, first, the container body 10H is placed in a worn state with the edge 15 in close contact with the face of the periphery of the eye 1000. At this time, the bottom part 11H may be removed from the peripheral wall 12. After the subject wears the device 100H, the bottom part 11H carrying the eye stimulant 90 is attached to the peripheral wall 12. The eye stimulant 90 is placed in a state in which a substrate solution or water can be dropped to generate gas. The gas generated from the eye stimulant 90 is supplied to the gas supply space 70H, thereby stimulating the eye 1000 of the subject. This causes tears secreted from the eye 1000 to flow out of the eye 1000 from the lower outer corner 1002 side. The flowing tears flow into the tear storage section 80H of the container body 10H. In this way, the tears are collected by the container body 10H. With the device 100H as described above, the collection of tears can be achieved while minimizing the burden on the subject. This can be done efficiently.

[0124] Fig. 14 shows a device 100I according to an embodiment. In the following description, components common to the device 100A shown in Figs. 1 and 2 are given the same reference numerals as in Figs. 1 and 2, and description thereof will be omitted. 14 includes a container body 10I. The container body 10I has a bottom 11, a peripheral wall 12, an opening 13, and a rim 15. A stimulant disposing section 60I, a gas supply space 70I, and a tear fluid containing section 80I are disposed within the container body 10I.

[0125] The stimulant arranging section 60I is disposed on the inner circumferential surface of the peripheral wall 12. The stimulant arranging section 60I may be disposed on the inner circumferential surface of the peripheral wall 12 at a position biased towards the first side Db1 in the second direction Db. The stimulant arranging section 60I is disposed on the peripheral wall inner circumferential surface 114 on the first end 101 side of the peripheral wall 12. The stimulant arranging section 60I may, for example, fix the ocular stimulant 90 to the peripheral wall inner circumferential surface 114 with an adhesive or the like.

[0126] The gas supply space 70I is defined by the container body 10I. The gas generated from the eye stimulant 90 arranged in the stimulant arrangement portion 60I can fill (permeate) the entire inside of the container body 10I. In an embodiment of the present disclosure, the gas supply space 70I is the entire inside of the container body 10I.

[0127] The tear storage section 80I is formed inside the container body 10I. To collect tear from the subject's eye 1000 using the device 100I, the container body 10I is worn with the edge 15 in close contact with the face around the periphery of the eye 1000. The subject tilts his / her head so that the outer corner 1002 side of the eye 1000 against which the container body 10I is pressed is downward relative to the inner corner 1001. The tear storage section 80I is formed in the container body 10I in an area on the second side Db2 side in the second direction Db, which is the outer corner 1002 side of the eye.

[0128] The gas generated from the eye stimulant 90 is supplied to the gas supply space 70I, thereby stimulating the eye 1000 of the subject. As a result, the tears secreted from the eye 1000 flow out of the eye 1000 from the lower outer corner 1002 side. The flowing tears flow into the tear storage section 80I of the container body 10I. In this way, the tears are collected by the container body 10I. With the device 100I described above, it is possible to efficiently collect tears while reducing the burden on the subject.

[0129] Figure 15 shows a device 100J according to an embodiment. In the following description, components common to the device 100A shown in Figures 1 and 2 are given the same reference numerals as in Figures 1 and 2, and description thereof will be omitted. 15 includes a container body 10J. The container body 10J has a bottom 11J, a peripheral wall 12, an opening 13, and a rim 15.

[0130] The bottom 11J includes a pedestal portion 117. The pedestal portion 117 rises from the periphery of the bottom 11J toward the inside of the bottom 11J toward one side Da1 in the first direction Da. The pedestal portion 117 is formed in a circular shape when viewed from the first direction Da. The pedestal portion 117 is formed so that the outer diameter gradually decreases from the bottom 11J toward the one side Da1 in the first direction Da. The pedestal portion 117 is formed in a substantially truncated cone shape. In the bottom 11J, an annular recess 127 having a circular ring shape when viewed from the first direction Da is formed on the radial outer side of the pedestal portion 117.

[0131] A stimulant locating section 60J, a gas supplied space 70J, and a tear containing section 80J are arranged within the container body 10J. The stimulant placement portion 60J is disposed on the base portion 117. The gas supply space 70J is defined by the container body 10J. The gas generated from the ocular stimulant 90 disposed in the stimulant placement portion 60J can fill (saturate) the entire inside of the container body 10J. In an embodiment of the present disclosure, the gas supply space 70J is the entire inside of the container body 10J. The tear storage portion 80J is formed inside the container body 10J. The tear storage portion 80J is formed in an annular recess 127 formed in the bottom portion 11J.

[0132] The gas generated from the eye stimulant 90 is supplied to the gas supply space 70J, thereby stimulating the eye 1000 of the subject. As a result, tears secreted from the eye 1000 flow out of the eye 1000 from the lower outer corner 1002 side. The flowing tears flow into the tear storage section 80J of the container body 10J. In this way, the tears are collected by the container body 10J. With the device 100J as described above, it is possible to efficiently collect tears while minimizing the burden on the subject.

[0133] Fig. 16 shows a device 100K according to an embodiment. In the following description, components common to the device 100A shown in Figs. 1 and 2 are given the same reference numerals as in Figs. 1 and 2, and description thereof will be omitted. A device 100K shown in FIG. 16 includes a container body 10K.

[0134] Container body 10K has a bottom 11, a peripheral wall 12, an opening 13, and a rim 15. A stimulant disposing portion 60K, a gas supplied space 70K, and a tear containing portion 80K are arranged within container body 10K.

[0135] The stimulant placement section 60K includes a holding section main body 61 and a connecting member 62. The holding section main body 61 holds the eye stimulant 90. The holding section main body 61 may be formed, for example, in a frame shape corresponding to the outer shape of the eye stimulant 90 so as to hold the outer periphery of the eye stimulant 90. The holding section main body 61 may have any other configuration as long as it can hold the eye stimulant 90. One end of the connecting member 62 is connected to the holding section main body 61. The other end of the connecting member 62 is connected to the container body 10K. The connecting members 62 are provided on both sides of the holding section main body 61. The eye stimulant 90 held in the holding section main body 61 is held by a plurality of connecting members 62. In the embodiment of the present disclosure, the connecting member 62 is provided as, for example, two connecting members. The connecting member 62 may include three or more connecting members. The holder body 61 and the eye stimulant 90 supported by the connecting member 62 may be disposed away from the bottom 11 on one side Da1 in the first direction Da. The holder body 61 and the eye stimulant 90 supported by the connecting member 62 may be disposed in contact with the bottom 11. By floating the connecting member 62 in the internal space of the container body 10K, for example, the volatilization efficiency of the lachrymatory component is increased.

[0136] The gas supply space 70K is defined by the container body 10K. The gas generated from the eye stimulant 90 arranged in the stimulant arrangement portion 60K can fill (permeate) the entire inside of the container body 10K. In an embodiment of the present disclosure, the gas supply space 70K is the entire inside of the container body 10K.

[0137] The tear storage section 80K is formed inside the container body 10K. The gas generated from the eye stimulant 90 is supplied to the gas supply space 70K, stimulating the eye 1000 of the subject. As a result, the tear secreted from the eye 1000 flows into the tear storage section 80K of the container body 10K. If the holding section body 61 supported by the connecting member 62 and the eye stimulant 90 are arranged away from the bottom 11 on one side Da1 in the first direction Da, the eye stimulant 90 is prevented from coming into contact with the tear. In the device 100K described above, it is possible to efficiently collect the tear while reducing the burden on the subject.

[0138] Figure 17 shows a device 100L according to an embodiment. In the following description, components common to the device 100A shown in Figures 1 and 2 are given the same reference numerals as in Figures 1 and 2, and description thereof will be omitted.

[0139] The device 100L shown in FIG.

[0140] The container body 10L has a bottom 11, a peripheral wall 12, an opening 13, and a rim 15. The detachable member 300 is configured to be detachable from the opening 13. The detachable member 300 is configured to close the opening 13 when attached to the opening 13.

[0141] The stimulant arranging portion 60L is disposed in the detachable member 300. When the detachable member 300 is attached to the opening 13, the stimulant arranging portion 60L is disposed on the surface of the detachable member 300 facing the inside of the container body 10L. The stimulant placement part 60L holds the eye stimulant 90. The stimulant placement part 60L is attached to the opening 13 of the container body 10L in a state in which a substrate solution or water is dropped onto the eye stimulant 90 and gas can be generated from the eye stimulant 90. This causes gas to be supplied into the container body 10L.

[0142] The gas supply space 70L is defined by the container body 10L. The gas generated from the eye stimulant 90 arranged in the stimulant arrangement section 60L can fill (saturate) the entire inside of the container body 10L. In the embodiment of the present disclosure, the gas supply space 70L is the entire inside of the container body 10L. The tear storage section 80L is formed inside the container body 10L.

[0143] When collecting tears, the detachable member 300 is attached to the opening 13 of the container body 10L in a state in which gas can be generated from the eye stimulant 90. When the gas generated from the eye stimulant 90 is supplied to the gas supply space 70L, the detachable member 300 is removed from the opening 13. The user presses the edge 15 of the container body 10L against the face of the peripheral part of the eye 1000 before the gas diffuses from the gas supply space 70L. This causes the subject's eye 1000 to come into contact with the gas and be stimulated. As a result, the tears secreted from the eye 1000 flow into the tear storage section 80L of the container body 10L. With the device 100L as described above, it is possible to efficiently collect tears while reducing the burden on the subject.

[0144] Figure 18 shows a device 100M according to an embodiment. In the following description, components common to the device 100A shown in Figures 1 and 2 are given the same reference numerals as in Figures 1 and 2, and description thereof will be omitted.

[0145] The device 100M shown in FIG. 14 includes a container body 10M and a tear container 400.

[0146] The container body 10M may be any one of the container bodies 10A to 10L described above.

[0147] The tear container 400 is provided integrally with the container body 10M. The tear container 400 collects the tear contained in the tear container 80M. The tear container 400 is disposed so as to extend outward from the opening 13 of the container body 10M. The tear container 400 is formed in a cylindrical shape with a bottom. The tear container 400 has a container opening 401 that opens toward the inner corner 1001 side when the container body 10M is worn with the edge 15 of the container body 10M in close contact with the face around the edge of the eye 1000.

[0148] The subject tilts his / her head so that the outer corner 1002 side of the eye 1000 against which the container body 10M is pressed is downward relative to the inner corner 1001. The gas generated from the eye stimulant 90 arranged in the stimulant arrangement section 60M is supplied to the gas supply space 70M, thereby stimulating the subject's eye 1000. As a result, the tears secreted from the eye 1000 flow out of the eye 1000 from the outer corner 1002 side on the lower side. The flowing tears flow into the tear storage section 80M of the container body 10M. By tilting the device 100M so that the tear container 400 is on the lower side, the tears in the tear storage section 80M of the container body 10M can be collected by the tear container 400. The tears flowing out of the eye 1000 may be collected directly by the tear container 400. In this case, the inside of the tear container 400 forms the tear storage section 80M.

[0149] Fig. 19 shows a device 100N according to an embodiment. In the following description, components common to the device 100A shown in Fig. 1 and Fig. 2 are given the same reference numerals as in Fig. 1 and Fig. 2, and description thereof will be omitted.

[0150] 19 includes a container body 10N and an access opening 500. The container body 10N may be any one of the container bodies 10A to 10L described above.

[0151] The access opening 500 is formed, for example, on the rim 125 of the container body 10N. The access opening 500 is formed so that the inside of the container body 10N can be accessed from the outside when the container body 10N is worn with the rim 15 in close contact with the face of the rim of the eye 1000. The access opening 500 is used to collect the tears contained in the tear container 80N of the container body 10N with a collector such as a dropper. The collector can access the tears contained in the tear container 80N through the access opening 500. The access opening 500 can also be used to feed gas generated from the eye irritant 90 disposed outside the container body 10N into the container body 10N. In some embodiments, the access opening 500 may be configured to be substantially sealable. The access opening may not be completely sealed, and may be sealed to such an extent that the lachrymatory component can sufficiently cause a lachrymatory effect on the eyeball. For example, the access opening may have an openable and closable lid. For example, the access opening may have a clasp-shaped resilient lid (including a garbage disposal splash guard).

[0152] Fig. 20 shows a device 100X according to an embodiment. The device 100X shown in Fig. 20 includes a container body 10X and a fastener 600X.

[0153] The container body 10X may be any one of the container bodies 10A to 10N (devices 100A to 100N) described above.

[0154] The fastener 600X fastens the container body 10X to the head of the user so that the edge 15 is in close contact with the face around the eye 1000. For example, the fastener 600X may be a rubber string (rubber band), a string, a belt, a tape with a hook-and-loop fastener, or the like. For example, one end of the two strings 601 is connected to one side of the container body 10X in the second direction Db. One end of the rubber string 602 is connected to the other side of the container body 10X in the second direction Db. The other end of the two strings 601 is connected to the other end of the rubber string 602. The container body 10X is attached to the head of the subject by such a fastener 600X.

[0155] Fig. 21 shows a device 100Y according to an embodiment. The device 100Y shown in Fig. 21 includes two container bodies 10Y, a connecting member 700Y, and a fastener 600Y.

[0156] The container body 10Y may be any one of the container bodies 10A to 10N (devices 100A to 100N) described above.

[0157] The connecting member 700Y connects the first ends 101 of the two container bodies 10Y to each other. The first end 101 of the container body 10Y is the eye corner side end of the container body 10Y that is on the eye corner 1001 side when the two container bodies 10Y are worn with the edges 15 in close contact with the face around the eyes 1000.

[0158] The fastener 600Y fastens the two container bodies 10Y to the head of the user so that the edge 15 is in close contact with the face of the periphery of the eye 1000. For example, an elastic cord (rubber band), a string, a belt, a tape with a hook-and-loop fastener, etc. can be used as the fastener 600Y. The fastener 600Y connects the second ends 102 of the two container bodies 10Y to each other. The second end 102 is an end on the outer corner of the eye that is on the outer corner 1002 side when the two container bodies 10Y are attached with the edge 15 in close contact with the face of the periphery of the eye 1000. To attach the device 100Y to the user, the fastener 600Y is hung on the back of the user's head with the edge 15 of the two container bodies 10Y in close contact with the face of the periphery of the eye 1000.

[0159] Fig. 22 shows a device 100Z according to an embodiment. The device 100Z shown in Fig. 22 includes two container bodies 10Z, a connecting member 700Z, and a fastener 600Z. The container body 10Z may be any one of the container bodies 10A to 10N (devices 100A to 100N) described above.

[0160] The connecting member 700Z connects the first ends 101 of the two container bodies 10Z to each other. The first end 101 of the container body 10Z is the eye corner side end of the container body 10Z that faces the eye corner 1001 when the two container bodies 10Z are worn with their edges 15 in close contact with the face around the periphery of the eye 1000. The connecting member 700Z may be in the form of a frame having a frame 701 formed to surround the two container bodies 10Z.

[0161] The fastener 600Z fastens the two container bodies 10Z to the head of the user so that the rim 15 is in close contact with the face around the eye 1000. The fastener 600Z may be formed like a vine of glasses. The fastener 600Z extends from the second ends 102 of the two container bodies 10Z. When the connecting member 700Z has a frame 701, the fastener 600Z may be connected to the frame 701. To attach the device 100Z to a user, the two container bodies 10Z are placed with the edges 15 of the container bodies 10Z in close contact with the face around the periphery of the eye 1000, and the fasteners 600Z are hung around the user's ears.

[0162] The present disclosure also provides the following embodiments: A101 The container body has a rim that can be fitted closely to the face around the eye, and defines a gas supply space therein into which the gas generated from the eye irritant can be filled. A device for producing tears. A111 The device of embodiment A101, The device further comprises a stimulant placement section that communicates with the gas supply space and in which the eye stimulant is placed. A112 The device of embodiment A111, The stimulant placement portion is formed in at least a part of the gas supply space. device. A121 A device according to any one of embodiments A101 to A112, comprising The device further comprises a tear storage section inside the container body for collecting tears secreted from the eye. A131 A device according to any one of embodiments A101 to A121, comprising The container body includes: A cup-shaped container having an opening that opens toward one side in the first direction, The edge is formed continuously around the entire periphery of the opening. device. A132 A device according to embodiment A131, comprising The container body forms a substantially closed space between the eye and the eye when the edge of the container body is in close contact with the face around the eye. device. A133 A device according to embodiment A131 or A132, comprising The container body includes: A bottom portion disposed on the other side in the first direction; A peripheral wall rising from a peripheral edge of the bottom portion to one side in the first direction. device. A141 A device according to embodiment A133, comprising A device comprising a partition wall disposed inside the container body, the partition wall separating the gas supply portion from the tear fluid containing portion. A142 The device of embodiment A141, The container body has a first end located on the outer corner of the eye and a second end located on the inner corner of the eye when the container body is worn with the edge in close contact with a face in the peripheral area of ​​the eye, The partition wall is disposed between the first end and the second end and partitions the inside of the container body into a first partition on the first end side and a second partition on the second end side. device. A143 The device of embodiment A142, comprising: The first compartment forms the tear fluid storage section, and the second compartment forms the gas supply space. device. A144 The device of embodiment A141, The container body has an upper end located on the upper eyelid side and a lower end located on the lower eyelid side when the container body is worn with the edge in close contact with the face around the eye, The partition wall is disposed between the upper end and the lower end and partitions the inside of the container body into an upper compartment on the upper end side and a lower compartment on the lower end side. device. A145 The device of embodiment A141, The entire circumference of the outer circumferential end of the partition wall is joined to the inner circumferential surface of the container body, forming an enclosed space between the partition wall and the inner circumferential surface of the container body, The sealed space forms the stimulant placement portion, The partition wall has a vent hole communicating with both sides thereof. device. A146 The device of embodiment A141, The partition wall is formed in a cylindrical shape rising from the bottom portion to one side in the first direction, The stimulant placement portion is arranged inside the cylindrical partition wall, device. A147 The device of embodiment A141, The partition wall is disposed at a middle position of the peripheral wall in the first direction, in a plane direction intersecting the first direction, and partially partitions an internal space of the container body, The stimulant placement portion is disposed on the bottom side in the first direction with respect to the partition wall, The tear fluid storage portion is formed on the partition wall on the opposite side to the bottom portion in the first direction. device. A148 The device of embodiment A147, comprising: The partition wall is formed to have a communication portion that communicates an internal space of the container body from the bottom side to an opposite side in the first direction, The communication portion is disposed on the inner corner side of the eye in a wearing state in which the edge of the container body is in close contact with the face in the peripheral area of ​​the eye. device. A149 The device of embodiment A148, comprising: The partition wall is inclined toward the bottom in the first direction from the communication portion toward the peripheral wall. device. A151 A device according to any one of embodiments A133 to A149, comprising The stimulant placement portion is formed on the bottom of the container body. device. A152 The device according to embodiment A151, The container body has a first end located on the outer corner of the eye and a second end located on the inner corner of the eye when the container body is worn with the edge in close contact with a face in the peripheral area of ​​the eye, The bottom portion is inclined from a bottom portion intermediate portion between the first end and the second end toward the other side in the first direction toward the first end side and the second end side. device. A153 The device of embodiment A152, comprising: The stimulant placement portion is formed on the bottom portion toward the second end side relative to the bottom portion intermediate portion. device. A154 The device according to embodiment A151, The bottom portion includes a platform portion that protrudes from a peripheral edge of the bottom portion toward the inside of the bottom portion on one side in the first direction, The stimulant placement portion is formed on the base portion. device. A155 The device according to embodiment A151, The bottom portion is detachable from the peripheral wall, The stimulant placement portion is disposed on the bottom portion. device. A156 A device according to any one of embodiments A133 to A148, comprising The stimulant placement portion is formed on the inner circumferential surface of the peripheral wall, device. A157 A device according to any one of embodiments A133 to A148, comprising The stimulant placement section includes: A holder body for holding the eye stimulant; A connecting member having one end connected to the holder body and the other end connected to the container body; Equipped with device. A158 A device according to any one of embodiments A133 to A148, comprising a detachable member that is detachable from the opening of the container body, The stimulant placement portion is placed on a surface of the detachable member facing the inside of the container body when the detachable member is attached to the opening. device. A161 A device according to any one of embodiments A101 to A158, comprising: The device further comprises a tear fluid container that is integral with the container body and that collects the tear fluid contained in the tear fluid storage section. A162 The device according to embodiment A161, The tear fluid container is formed in a bottomed tubular shape extending outward from the opening of the container body. device. A163 The device of embodiment A162, comprising: The tear container is positioned on the outer corner of the eye with respect to the container body in a wearing state in which the edge is in close contact with the face around the eye, The tear container has a container opening that opens to the inner corner side of the eye. device. A171 A device according to any one of embodiments A101 to A163, comprising The container body has an access opening through which the inside of the container body can be accessed from the outside when the container body is worn with the edge in close contact with the face around the eye. device. A172 A device according to any one of embodiments A101 to A171, comprising: At least a part or all of the container body is formed of a transparent material that allows the inside of the container body to be optically confirmed from the outside. device. A181 A device according to any one of embodiments A101 to A172, comprising: The device further comprises a fibrous tissue carrying the ocular irritant and disposed in the irritant placement portion. A182 A device according to any one of embodiments A101 to A172, comprising The eye irritant is in liquid form and sealed in a bag. device. A191 A device according to any one of embodiments A101 to A182, comprising The eye irritant comprises benzyl bromide. device. A192 A device according to any one of embodiments A101 to A182, comprising The ocular irritant comprises syn-propanethial-S-oxide. device. A193 A device according to any one of embodiments A101 to A192, comprising: The ocular irritant comprises at least a portion of an enzyme and a substrate that react to generate the gas. device. A194 The device of embodiment A193, comprising: The enzyme is placed in the stimulant placement portion in a dry state, The substrate is configured to be added to the enzyme in solution. device. A195 The device of embodiment A194, comprising: The enzymes are allinase and lachrymal factor synthase (LFS), The substrate is PRENCSO. device. A201 A device according to any one of embodiments A101 to A195, comprising: Two of the container bodies; A connecting member that connects the inner corner side end portions of the two container bodies that are located on the inner corner side of the eye in a wearing state in which the two container bodies are in close contact with the face around the eye with the edges of the container bodies being in close contact with the face around the eye, 16. A device comprising: A211 A device according to any one of embodiments A101 to A201, comprising: The device further comprises a fastener capable of fastening the container body to the subject's head so as to fit the rim closely to the face in the periphery of the eye. A211b The device of embodiment A201, The device further comprises a fastener for each of the two container bodies, which is provided at the end on the outer corner of the eye that is adjacent to the outer corner of the eye when the two container bodies are worn with the edges in close contact with the face around the eye, and which can fasten the container body to the subject's head.

[0163] While preferred embodiments of the present invention have been shown and described herein, it will be apparent to those skilled in the art that such embodiments are provided by way of example only. The present invention is not intended to be limited by the specific examples provided herein. Although the present invention has been described with reference to the above specification, the descriptions and illustrations of the embodiments herein are not intended to be construed in a limiting sense. Numerous variations, changes, and substitutions will occur to those skilled in the art without departing from the present invention. Furthermore, it is to be understood that all aspects of the present invention are not limited to the specific depictions, configurations, or relative proportions described herein which depend upon a variety of conditions and variables. It is to be understood that various alternatives to the embodiments of the present invention described herein may be used in carrying out the present invention. It is therefore contemplated that the present invention will cover such alternatives, modifications, variations, or equivalents. It is intended that the following claims define the scope of the present invention, and that methods and structures within the scope of these claims and their equivalents are covered thereby. [Explanation of symbols]

[0164] 10A~10N, 10X~10Z Container body 11, 11G, 11H, 11J bottom 12 Surrounding wall 13 Aperture 15. Edge 20A~20E Partition wall 21 Outer edge 60A~60L Stimulant placement section 60X~60Z locking tool 61 Holding part body 62 Connection parts 70A~70M Gas supply space 80A~80N Tear fluid storage section 90 Eye irritants 91 Fibrous Tissue 100A~100N, 100X~100Z devices 101 First end 102 Second end 103 Upper edge 104 Lower edge 111 First Section 112 Second Section 115 Bottom middle part 117 Daibu 121 Upper Section 122 Lower Section 125 Periphery 131 Closed space 220 Vent 230 Communication section 300 Detachable parts 320 Vent 400 Tear container 401 Container opening 500 Access opening 600X~600Z Locking tool 700Y, 700Z Connector 1000 eyes 1001 Eye corner 1002 Eye corner 1003 Upper eyelid 1004 Lower eyelid Da First direction Da1 One side Da2 other side Db second direction Dc third direction

Claims

1. The container body has a rim that can be fitted closely to the face around the eye, and defines a gas supply space therein into which the gas generated from the eye irritant can be filled. A device for producing tears.

2. The gas supply space is connected to the irritant placement section, and the irritant placement section is further provided. The device of claim 1 .

3. The stimulant placement portion is formed in at least a part of the gas supply space. The device of claim 2.

4. The container body further includes a tear storage section for collecting tears secreted from the eye. A device according to any one of claims 1 to 3.

5. The container body includes: A cup-shaped container having an opening that opens toward one side in the first direction, The edge is formed continuously around the entire periphery of the opening. A device according to any one of claims 1 to 4.

6. The container body forms a substantially closed space between the eye and the eye when the edge of the container body is in close contact with the face around the eye. The device of claim 5.

7. The container body includes: A bottom portion disposed on the other side in the first direction; A peripheral wall rising from a peripheral edge of the bottom portion to one side in the first direction.

7. A device according to claim 5 or 6.

8. a partition wall that partitions the gas supply space and the tear fluid storage section from each other is provided inside the container body; The device of claim 7.

9. The container body has a first end located on the outer corner of the eye and a second end located on the inner corner of the eye when the container body is worn with the edge in close contact with a face in the peripheral area of ​​the eye, The partition wall is disposed between the first end and the second end and partitions the inside of the container body into a first partition on the first end side and a second partition on the second end side. The device of claim 8.

10. The first compartment forms the tear fluid storage section, and the second compartment forms the gas supply space. The device of claim 9.

11. The container body has an upper end located on the upper eyelid side and a lower end located on the lower eyelid side when the container body is worn with the edge in close contact with the face around the eye, The partition wall is disposed between the upper end and the lower end and divides the inside of the container body into an upper compartment on the upper end side and a lower compartment on the lower end side. The device of claim 8.

12. The entire circumference of the outer circumferential end of the partition wall is joined to the inner circumferential surface of the container body, forming an enclosed space between the partition wall and the inner circumferential surface of the container body, The sealed space forms the stimulant placement portion, The partition wall has a vent hole communicating with both sides thereof. The device of claim 8.

13. The partition wall is formed in a cylindrical shape rising from the bottom portion to one side in the first direction, The stimulant placement portion is arranged inside the cylindrical partition wall, The device of claim 8.

14. The partition wall is disposed at a middle position of the peripheral wall in the first direction, in a plane direction intersecting the first direction, and partially partitions an internal space of the container body, The stimulant placement portion is disposed on the bottom side in the first direction with respect to the partition wall, The tear fluid storage portion is formed on the partition wall on the opposite side to the bottom portion in the first direction. The device of claim 8.

15. The partition wall is formed to have a communication portion that communicates an internal space of the container body from the bottom side to an opposite side in the first direction, The communication portion is disposed on the inner corner side of the eye in a wearing state in which the edge of the container body is in close contact with the face in the peripheral area of ​​the eye. The device of claim 14.

16. The partition wall is inclined toward the bottom in the first direction from the communication portion toward the peripheral wall.

16. The device of claim 15.

17. The stimulant placement portion is formed on the bottom of the container body. A device according to any one of claims 7 to 16.

18. The container body has a first end located on the outer corner of the eye and a second end located on the inner corner of the eye when the container body is worn with the edge in close contact with a face in the peripheral area of ​​the eye, The bottom portion is inclined from a bottom portion intermediate portion between the first end and the second end toward the other side in the first direction toward the first end side and the second end side.

20. The device of claim 17.

19. The stimulant placement portion is formed on the bottom portion toward the second end side relative to the bottom portion intermediate portion.

20. The device of claim 18.

20. The bottom portion includes a platform portion that protrudes from a peripheral edge of the bottom portion toward the inside of the bottom portion on one side in the first direction, The stimulant placement portion is formed on the base portion.

20. The device of claim 17.

21. The bottom portion is detachable from the peripheral wall, The stimulant placement portion is disposed on the bottom portion.

20. The device of claim 17.

22. The stimulant placement portion is formed on the inner circumferential surface of the peripheral wall, A device according to any one of claims 7 to 15.

23. The stimulant placement section includes: A holder body for holding the eye stimulant; A connecting member having one end connected to the holder body and the other end connected to the container body; Equipped with A device according to any one of claims 7 to 15.

24. a detachable member that is detachable from the opening of the container body, The stimulant placement portion is placed on a surface of the detachable member facing the inside of the container body when the detachable member is attached to the opening. A device according to any one of claims 7 to 15.

25. The device further includes a tear fluid container that is integral with the container body and that collects the tear fluid contained in the tear fluid container.

25. A device according to any one of claims 1 to 24.

26. The tear fluid container is formed in a bottomed tubular shape extending outward from the opening of the container body.

26. The device of claim 25.

27. The tear container is disposed on the outer corner of the eye with respect to the container body in a wearing state in which the edge is in close contact with the face around the eye, The tear container has a container opening that opens toward the inner corner of the eye.

27. The device of claim 26.

28. The container body has an access opening through which the inside of the container body can be accessed from the outside when the container body is worn with the edge in close contact with the face around the eye.

28. A device according to any one of claims 1 to 27.

29. At least a part or all of the container body is formed of a transparent material that allows the inside of the container body to be optically confirmed from the outside.

29. A device according to any one of claims 1 to 28.

30. Further comprising a fibrous tissue that carries the eye irritant and is placed in the irritant placement portion; 30. A device according to any one of claims 1 to 29.

31. The eye irritant is in liquid form and sealed in a pouch.

30. A device according to any one of claims 1 to 29.

32. The eye irritant comprises benzyl bromide.

32. A device according to any one of claims 1 to 31.

33. The ocular irritant comprises syn-propanethial-S-oxide.

33. A device according to any one of claims 1 to 32.

34. The ocular irritant comprises at least a portion of an enzyme and a substrate that react to generate the gas.

34. A device according to any one of claims 1 to 33.

35. The enzyme is placed in the stimulant placement portion in a dry state, The substrate is configured to be added to the enzyme in solution.

35. The device of claim 34.

36. The enzymes are allinase and lachrymal factor synthase (LFS), The substrate is PRENCS0.

36. The device of claim 35.

37. Two of the container bodies; and a connecting member that connects the eye corner side end portions of the two container bodies that are located on the eye corner side when the two container bodies are attached in a state in which the edges are in close contact with the face around the eyes.

37. A device according to any one of claims 1 to 36.

38. The container body further includes a fastener that can fasten the container body to the subject's head so that the edge is in close contact with the face around the eye.

38. A device according to any one of claims 1 to 37.

39. Each of the two container bodies further includes a fastener that is provided at the end portion on the outer corner of the eye that is the outer corner of the eye when the two container bodies are worn with the edges in close contact with the face around the eye, and that can fasten the container body to the head of the subject.

38. The device of claim 37.

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