Aqueous dispersion composition

Abstract

To provide an aqueous dispersion composition with a poorly soluble component, exemplified by ceramide, dispersed in water, which can be prepared by a simple method without the need for complex operations, and which exhibits high transparency and superior dispersion stability.SOLUTION: A water dispersion composition is used which contains the following components (A) to (C) in a specific ratio: (A) A lipid composition comprising the following components (A1) to (A3): (A1) One or more selected from mono- or diesters of fatty acids having 8 to 22 carbon atoms and polyglycerin having a degree of polymerization of 6 to 22, and monoesters of fatty acids having 8 to 22 carbon atoms and sucrose. (A2) Phospholipids. (A3) One or more poorly soluble components selected from ceramides, sterols, carotenoids, tocopherols, lipoic acid, and coenzyme Q10. (B) Polyhydric alcohol. (C) Water.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to an aqueous dispersion composition in which a lipid composition comprising a specific nonionic surfactant, a phospholipid and a poorly soluble component is dispersed in water. [Background technology]

[0002] It is generally known that poorly soluble components such as ceramides are not soluble in water, are poorly soluble in oils, and are highly crystalline, so that it is difficult to disperse such components in water. As a method for dispersing such poorly soluble components in water, a method is used in which the components are dissolved in oils at high temperatures and then dispersed in water using a surfactant. However, in order to obtain a highly transparent and stable water-dispersed composition by this method, a large amount of surfactant is required, which raises concerns about skin irritation, and it is difficult to disperse at a high concentration. On the other hand, Patent Document 1 describes a method for dispersing a lipid dispersion composition containing phospholipids, ceramide, and polyhydric alcohol in an aqueous medium as a method for dispersing a large amount of ceramide in water stably. However, although the water-dispersed composition obtained by the method of Reference Document 1 has excellent dispersion stability, in order to obtain a highly transparent water-dispersed composition, complicated operations such as high-pressure treatment using a microfluidizer or granulation using an extruder were required. Therefore, a method for obtaining a water-dispersed composition with high transparency and excellent dispersion stability more easily was desired.

[0003] Polyglycerol fatty acid esters and sucrose fatty acid esters are nonionic surfactants that are synthesized from natural ingredients and are used in food applications, and are widely used as raw materials for cosmetics and skin care products.Lecithin is a generic name for naturally derived phospholipids obtained from animals or plants, and is very safe for humans, does not cause irritation to the skin, and has moisturizing properties and a unique, excellent feel when used, so it is widely used as raw materials for cosmetics and skin care products.However, there has been no known attempt to disperse a lipid composition that is composed of polyglycerol fatty acid esters or sucrose fatty acid esters, lecithin, and a poorly soluble component in water. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Japanese Patent Application Publication No. 11-130651 Summary of the Invention [Problem to be solved by the invention]

[0005] An object of the present invention is to provide an aqueous dispersion composition in which a poorly soluble component, typically a ceramide, is dispersed in water, which can be prepared by a simple method that does not require complicated operations, and which has high transparency and excellent dispersion stability. [Means for solving the problem]

[0006] As a result of extensive investigations aimed at solving the above problems, the inventors have found that an aqueous dispersion composition containing the following components (A) to (C) in specific ratios can solve the above problems, and have completed the present invention. (A) A lipid composition comprising the following components (A1) to (A3): (A1) One or more selected from mono- or diesters of fatty acids having 8 to 22 carbon atoms and polyglycerols having a degree of polymerization of 6 to 22, and monoesters of fatty acids having 8 to 22 carbon atoms and sucrose. (A2) Phospholipids (A3) One or more poorly soluble components selected from ceramides, sterols, carotenoids, tocopherols, lipoic acid, and coenzyme Q10 (B) Polyhydric alcohol (C)Water Effect of the Invention

[0007] The water-dispersed composition of the present invention can be prepared by a simple method, and the resulting water-dispersed composition has high transparency and excellent dispersion stability even when it contains a high concentration of a poorly soluble component. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0008] The water dispersion composition of the present invention is characterized by containing the following components (A) to (C). (A) A lipid composition comprising the following components (A1) to (A3): (A1) One or more selected from mono- or diesters of fatty acids having 8 to 22 carbon atoms and polyglycerols having a degree of polymerization of 6 to 22, and monoesters of fatty acids having 8 to 22 carbon atoms and sucrose. (A2) Phospholipids (A3) One or more poorly soluble components selected from ceramides, sterols, carotenoids, tocopherols, lipoic acid, and coenzyme Q10 (B) Polyhydric alcohol (C)Water

[0009] The mono- or diester of a fatty acid having 8 to 22 carbon atoms and a polyglycerol having a degree of polymerization of 6 to 22, which is the component (A1) used in the present invention, is preferably a mono- or diester of a fatty acid having 12 to 18 carbon atoms and a polyglycerol having an average degree of polymerization of 6 to 10, and more preferably a mono- or diester of a fatty acid selected from lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid and isostearic acid and a polyglycerol having an average degree of polymerization of 6 to 10. Specific examples include polyglyceryl-6,-8,-10 laurate, polyglyceryl-6,-8,-10 myristate, polyglyceryl-6,-8,-10 palmitate, polyglyceryl-6,-8,-10 stearate, polyglyceryl-6,-8,-10 oleate, polyglyceryl-6,-8,-10 isostearate, polyglyceryl-6,-8,-10 dilaurate, polyglyceryl-6,-8,-10 dimyristate, polyglyceryl-6,-8,-10 dipalmitate, polyglyceryl-6,-8,-10 distearate, polyglyceryl-6,-8,-10 dioleate, polyglyceryl-6,-8,-10 diisostearate, etc. These may be used alone or in combination of two or more. Of these, polyglyceryl-10 laurate, polyglyceryl-10 myristate, polyglyceryl-10 palmitate, polyglyceryl-10 stearate, polyglyceryl-10 oleate, polyglyceryl-10 isostearate, polyglyceryl-10 dilaurate, polyglyceryl-10 dimyristate, polyglyceryl-10 dipalmitate, polyglyceryl-10 distearate, polyglyceryl-10 dioleate, and polyglyceryl-10 diisostearate are more preferred, and polyglyceryl-10 laurate, polyglyceryl-10 myristate, polyglyceryl-10 palmitate, polyglyceryl-10 stearate, polyglyceryl-10 oleate, and polyglyceryl-10 isostearate are even more preferred.

[0010] The monoester of sucrose and a fatty acid having 8 to 22 carbon atoms, component (A1), used in the present invention is preferably a monoester of sucrose and a fatty acid selected from lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, isostearic acid, arachidic acid, and behenic acid. Specific examples include sucrose laurate, sucrose myristate, sucrose palmitate, sucrose stearate, sucrose oleate, sucrose isostearate, sucrose arachidic acid, and sucrose behenate. These may be used alone or in combination of two or more. Of these, sucrose laurate, sucrose myristic acid, sucrose palmitate, sucrose stearate, sucrose oleate, and sucrose isostearate are more preferred.

[0011] Examples of the phospholipids of component (A2) used in the present invention include diacylglycerophospholipids having polar groups such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, and phosphatidic acid; natural lecithin obtained from plants such as soybean, rapeseed, sunflower, safflower, peanut, cottonseed, corn, rice, and barley, and egg yolk, and hydrogenated products thereof. Furthermore, these may be derivatives modified with polyoxyalkylene groups such as polyethylene glycol. These phospholipids may be used alone or in combination of two or more. Among these, lecithin and hydrogenated products thereof are preferred from the viewpoints of availability and further exerting the effects of the present invention. Lecithin with different phosphatidylcholine (hereinafter referred to as PC) contents depending on the degree of purification is commercially available, but in the present invention, it is preferable to use one with a PC content of 30% by mass or more, more preferably 40% by mass or more, and most preferably 50% by mass or more.

[0012] The component (A3) used in the present invention is one or more poorly soluble components selected from ceramides, sterols, carotenoids, tocopherols, lipoic acid, and coenzyme Q10. All of these are components known to have excellent efficacy and effects on the skin or hair. More specifically, examples of ceramides include ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6, ceramide 7, sphingosine, phytosphingosine, etc., and among these, ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6, and ceramide 7 are more preferred. Examples of sterols include cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol, desmosterol, stigmasterol, sitosterol, campesterol, brassicasterol, phytosterol, ergosterol, oryzanol, among which cholesterol, phytosterol, and oryzanol are more preferred. Examples of carotenoids include carotene, lycopene, cryptosanthin, lutein, zeaxanthin, astaxanthin, crocetin, and fucoxanthin, among which lutein and astaxanthin are more preferred. Examples of tocopherols include α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, α-tocotrienol, β-tocotrienol, γ-tocotrienol, δ-tocotrienol, tocopherol acetate, tocopherol nicotinate, and the like. Of these, α-tocopherol, β-tocopherol, γ-tocopherol, and δ-tocopherol are more preferred.

[0013] In the present invention, the mass ratio of components (A1) to (A2) is 6:4 to 1:9. If the mass ratio of components (A1) to (A2) is outside this range, the effects of the present invention, such as high transparency and excellent dispersion stability, are not sufficiently achieved. From the viewpoint of further achieving the effects of the present invention, the mass ratio of components (A1) to (A2) is more preferably 6:4 to 2:8, even more preferably 5.5:4.5 to 2:8, and most preferably 5.5:4.5 to 2.5:7.5.

[0014] In the present invention, the content of component (A3) in component (A) is 1 to 36% by mass. Even if the content of component (A3) is less than 1% by mass, the effect of the present invention can be achieved, but the concentration of component (A3) in the water-dispersed composition is low, which is not preferable in terms of fully achieving the efficacy and effect of component (A3). From this viewpoint, the content of component (A3) is more preferably 5% by mass or more, and even more preferably 10% by mass or more. In addition, if the content of component (A3) is more than 36% by mass, the effects of the present invention, such as high transparency and excellent dispersion stability, are not fully achieved. From the viewpoint of further achieving the effects of the present invention, the content of component (A3) is more preferably 34% by mass or less, and even more preferably 32% by mass or less.

[0015] In the present invention, the component (A) can be contained in the water-dispersed composition within a range that does not impair the effects of the present invention, and there is no particular restriction on the content, but from the viewpoint of the transparency and dispersion stability of the water-dispersed composition, the upper limit of the amount of the component (A) in the water-dispersed composition is preferably 15% by mass or less, more preferably 12% by mass or less, and even more preferably 10% by mass or less. On the other hand, there is no particular restriction on the lower limit of the amount of the component (A) in the water-dispersed composition, but from the viewpoint of further exerting the efficacy and effect of the component (A3), the content of the component (A3) in the water-dispersed composition is 0.2% by mass or more, preferably 0.5% by mass or more, and more preferably 1.0% by mass or more.

[0016] Examples of the polyhydric alcohols used in the present invention as component (B) include dihydric alcohols such as ethylene glycol, propylene glycol, 1,3-propanediol, 1,2-butylene glycol, 1,3-butylene glycol, 2,3-butylene glycol, tetramethylene glycol, hexylene glycol, octylene glycol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, and 1,2-decanediol; trihydric alcohols such as glycerin, trimethylolpropane, and 1,2,6-hexanetriol; and soybeans. Examples of the polyhydric alcohol include sugar alcohols such as glycerol, xylitol, erythritol, maltitol, and mannitol; glyceryl ethers such as ethylglycerin, butylglycerin, hexylglycerin, ethylhexylglycerin, and cyclohexylglycerin; polyhydric alcohol polymers such as diethylene glycol, triethylene glycol, tetraethylene glycol, polyethylene glycol, dipropylene glycol, tripropylene glycol, polypropylene glycol, diglycerin, triglycerin, tetraglycerin, polyglycerin, isosorbide, and derivatives thereof. These may be used alone or in combination of two or more. Of these, glycerin, propylene glycol, 1,3-propanediol, dipropylene glycol, 1,3-butylene glycol, 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, and 1,2-octanediol are preferred, and 1,3-butylene glycol, glycerin, 1,2-pentanediol, and 1,2-hexanediol are most preferred.

[0017] The water of component (C) used in the present invention is not particularly limited as long as it is usable in ordinary cosmetics, and may be purified water, ion-exchanged water, distilled water, natural water, deep sea water, hydrogen water, etc. In addition, the pH may be adjusted with an acid, alkali, buffer, chelating agent, etc., and water-soluble components such as preservatives may be added.

[0018] The water-dispersed composition of the present invention is characterized in that the lipid composition consisting of component (A), i.e., components (A1) to (A3), is dispersed in water. In order to disperse components (A1) to (A3) in water as component (A) in the water-dispersed composition of the present invention, it is necessary to add components (A1) to (A3) in a sufficiently mixed state to water at the same time. When components (A1), (A2), and (A3) are separately dispersed in water, the effects of the present invention, such as high transparency and excellent dispersion stability, are not achieved. From this viewpoint, a polyhydric alcohol of component (B) is used in the preparation of the water-dispersed composition of the present invention. That is, the water-dispersed composition of the present invention can be prepared by a simple operation of mixing components (A) and (B) with stirring to prepare a polyhydric alcohol solution in which each component of component (A) is sufficiently mixed, and adding water to the obtained polyhydric alcohol solution while stirring, or adding a polyhydric alcohol solution to water while stirring. The aqueous dispersion composition of the present invention prepared by such a simple method contains a poorly soluble component at a high concentration, but surprisingly, it can be obtained as a highly transparent composition without performing complicated operations such as high pressure treatment using a microfluidizer or granulation using an extruder. In preparing the aqueous dispersion composition of the present invention, component (B) may be used in an amount of 0.5 times by mass or more, more preferably 0.65 times by mass or more, relative to component (A). If the content of component (B) is less than this, component (A) cannot be sufficiently dispersed in component (B), and the effects of the present invention may not be fully achieved.

[0019] The polyhydric alcohol liquid obtained by stirring and mixing the components (A) and (B) of the present invention can also be used as a raw material for preparing the water-dispersed composition of the present invention. That is, the polyhydric alcohol liquid preparation step can be omitted by preparing and storing the polyhydric alcohol liquid containing the components (A) and (B) and using the required amount when preparing the water-dispersed composition. When the polyhydric alcohol liquid containing the components (A) and (B) of the present invention is solid at room temperature, it is recommended to warm it to dissolve it when using it.

[0020] The water-dispersed composition of the present invention is a composition in which component (A) is dispersed in water, and in this case, it is preferable that component (A) forms a lipid membrane structure. The lipid membrane structure means a vesicle, a bicelle, etc. It is believed that the formation of such a structure suppresses the precipitation of a poorly soluble component having high crystallinity, and thus the effect of the present invention of excellent dispersion stability is achieved.

[0021] In the water dispersion composition of the present invention, "high transparency" means that when a sample is placed in a glass bottle with a diameter of 3.5 cm and observed from the side, the sample has a transparency such that the back of the liquid can be seen through. When measuring the turbidity with a spectrophotometer, the transmittance is 60% or more when the sample is placed in a cell with a thickness of 1 cm and measured at a wavelength of 600 nm.

[0022] The aqueous dispersion composition of the present invention can be used as it is as a cosmetic or skin topical preparation, or can be used as a raw material for a cosmetic or skin topical preparation by blending it during production. When the aqueous dispersion composition of the present invention is used as a raw material for a cosmetic or skin topical preparation, the blending amount is not particularly limited, but is generally 0.01 to 99% by mass, preferably 0.05 to 90% by mass.

[0023] The cosmetic or topical skin preparation of the present invention may contain, as necessary, water and additional ingredients that are usually blended into cosmetics, such as oily bases, moisturizers, texture enhancers, surfactants, polymers, thickeners, gelling agents, antioxidants, reducing agents, oxidizing agents, antioxidants, whitening agents, vitamins and their derivatives, plant, animal, or microbial extracts, UV absorbers, antibacterial agents, preservatives, chelating agents, pH adjusters, acids, alkalis, solvents, propellants, antipruritics, keratin exfoliants, dissolving agents, antiperspirants, cooling agents, astringents, enzymes, nucleic acids, anti-inflammatory agents, anti-inflammatory agents, hair growth agents, blood circulation promoters, stimulants, hormones, anti-wrinkle and anti-aging agents, irritation mitigators, cooling agents, warming agents, powders, dyes, colorants, dyes, pigments, fragrances, and the like, to an extent that does not impair the effects of the present invention.

[0024] Examples of oily bases include higher alcohols such as cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, arachyl alcohol, behenyl alcohol, jojoba alcohol, chimyl alcohol, selachyl alcohol, batyl alcohol, hexyldecanol, isostearyl alcohol, 2-octyldodecanol, and dimer diol; aralkyl alcohols and derivatives such as benzyl alcohol; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, Higher fatty acids such as undecylenic acid, 12-hydroxystearic acid, palmitoleic acid, oleic acid, linoleic acid, linolenic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, isohexadecanoic acid, anteisohenicosanoic acid, long-chain branched fatty acids, long-chain α-hydroxy fatty acids, dimer acids, hydrogenated dimer acids, and their aluminum salts, calcium salts, magnesium salts, zinc salts, potassium salts, sodium salts, and other metal soaps, as well as nitrogen-containing derivatives such as amides; liquid paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin , α-olefin oligomer, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalene, petrolatum, solid paraffin, and other hydrocarbons; candelilla wax, carnauba wax, rice wax, Japan wax, beeswax, montan wax, ozokerite, ceresin, paraffin wax, microcrystalline wax, petrolatum, Fischer-Tropsch wax, polyethylene wax, ethylene-propylene copolymer, and other waxes; coconut oil, palm oil, palm kernel oil, safflower oil, olive oil , castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut oil, hazelnut oil, kukui nut oil, rosehip oil, meadowfoam oil, persic oil, tea tree oil, peppermint oil, corn oil, rapeseed oil, sunflower oil, wheat germ oil, linseed oil, cottonseed oil, soybean oil, peanut oil, rice bran oil, cocoa butter, shea butter, hydrogenated coconut oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba oil, and other vegetable oils and fats; beef tallow, milk fat, horse fat, egg yolk oil, mink oil, turtle oil, and other animal waxes; whale wax, lanolin, orange raffy oil, and other animal waxes;Lanolin derivatives such as liquid lanolin, reduced lanolin, adsorbed purified lanolin, acetated lanolin, acetated liquid lanolin, hydroxylanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, acetated lanolin alcohol, acetate (cetyl lanoyl) ester; lecithin, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, sphingomyelin, etc. Phospholipids such as lysophospholipids, phosphatidic acid, cyclic lysophosphatidic acid or its salt, and lysolecithin; phospholipid derivatives such as hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, and partially hydrogenated egg yolk phospholipid; sterols such as cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol, phytosterol, and cholic acid; sapogenins; saponins; cholesteryl acetate, cholesteryl nonanoate, cholesteryl stearate, Acyl sarcosine alkyl esters such as cholesteryl isostearate, cholesteryl oleate, N-lauroyl-L-glutamic acid di(cholesteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamic acid di(cholesteryl / octyldodecyl), N-lauroyl-L-glutamic acid di(phytosteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamic acid di(phytosteryl / octyldodecyl), and N-lauroyl sarcosine isopropyl. Sterol esters such as sterol esters of 12-hydroxystearate, cholesteryl macadamiate, phytosteryl macadamiate, phytosteryl sunflower seed oil, phytosteryl isostearate, cholesteryl soft lanolinate, cholesteryl hard lanolinate, cholesteryl long-chain branched fatty acid, and cholesteryl long-chain α-hydroxy fatty acid; lipid complexes such as phospholipid-cholesterol complex and phospholipid-phytosterol complex;Octyldodecyl myristate, hexyldecyl myristate, octyldodecyl isostearate, cetyl palmitate, octyldodecyl palmitate, cetyl octanoate, hexyldecyl octanoate, isotridecyl isononanoate, isononyl isononanoate, octyl isononanoate, isotridecyl isononanoate, isodecyl neopentanoate, isotridecyl neopentanoate, isostearyl neopentanoate, octyldodecyl neodecanoate, oleyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, octyldodecyl lanolinate, dicaprylyl carbonate, hexyldecyl dimethyloctanoate, octyldodecyl erucate, hydrogenated castor oil isostearate, Monoalcohol carboxylates such as ethyl oleate, avocado oil fatty acid ethyl, isopropyl myristate, isopropyl palmitate, octyl palmitate, isopropyl isostearate, isopropyl lanolin fatty acid, methylheptyl laurate, methylheptyl myristate, methylheptyl palmitate, methylheptyl isostearate, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, diisopropyl adipate, dibutyloctyl sebacate, diisobutyl adipate, dioctyl succinate, and triethyl citrate; oxyacid esters such as cetyl lactate, hydrogenated castor oil monoisostearate, γ-erucalactone, and diisostearyl malate;Glyceryl trioctanoate, glyceryl trioleate, glyceryl triisostearate, glyceryl diisostearate, caprylic / capric triglyceride, caprylic / capric / myristic / stearic triglyceride, hydrogenated rosin triglyceride (hydrogenated ester gum), rosin triglyceride (ester gum), glyceryl behenate eicosandioate, trimethylolpropane trioctanoate, trimethylolpropane triisostearate, neopentyl glycol dioctanoate, dicaprylate Neopentyl glycol dioctanoate, 2-butyl-2-ethyl-1,3-propanediol dioctanoate, propylene glycol dioleate, pentaerythrityl tetraoctanoate, hydrogenated rosin pentaerythrityl, ditrimethylolpropane triethylhexanoate, ditrimethylolpropane isostearate / sebacic acid, pentaerythrityl triethylhexanoate, dipentaerythrityl hydroxystearic acid / stearic acid / rosin acid, diglyceryl diisostearate, polyglyceryl tetraisostearate Polyhydric alcohol fatty acid esters such as polyglyceryl-10 nonaisostearate, polyglyceryl-8 deca(erucic acid / isostearate / ricinoleic acid), diglyceryl oligoester (hexyldecanoic acid / sebacic acid), glycol distearate (ethylene glycol distearate), 3-methyl-1,5-pentanediol dineopentanoate, 2,4-diethyl-1,5-pentanediol dineopentanoate; alkyl ethers such as dicaprylyl ether; diisopropyl dimer dilinoleate, ... -Diisostearyl dimer dilinoleate, di(isostearyl / phytosteryl) dimer dilinoleate, phytosteryl / behenyl dimer dilinoleate, phytosteryl / isostearyl / cetyl / stearyl / behenyl dimer dilinoleate, dimer dilinoleyl diisostearate, dimer dilinoleyl hydrogenated rosin condensate, dimer dilinoleic acid hydrogenated castor oil, hydroxyalkyl dimer dilinoleyl ether and other dimer acid or dimer diol derivatives;Fatty acid alkanolamides such as coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (palmitamide MEA), palmitic acid diethanolamide (palmitamide DEA), coconut oil fatty acid methylethanolamide (cocamide methyl MEA); dimethicone (dimethylpolysiloxane), highly polymerized dimethicone (highly polymerized dimethylpolysiloxane), cyclomethicone (cyclic dimethylsiloxane, decamethylcyclopentasiloxane), phenyl trimethicone, diphenyl dimethicone, phenyl dimethicone, (aminoethyl aminopropyl methicone / dimethicone) copolymer, dimethiconol, dimethiconol crosspolymer, silicone resin, silicone Preferred examples of the silicones include corn gum, amino-modified silicones such as aminopropyl dimethicone and amodimethicone, cationic modified silicones, polyether-modified silicones such as dimethicone copolyol, polyglycerin-modified silicones, sugar-modified silicones, carboxylic acid-modified silicones, phosphoric acid-modified silicones, sulfate-modified silicones, alkyl-modified silicones, fatty acid-modified silicones, alkyl ether-modified silicones, amino acid-modified silicones, peptide-modified silicones, fluorine-modified silicones, cationic and polyether-modified silicones, amino and polyether-modified silicones, alkyl and polyether-modified silicones, amidoalkyl-modified silicones, aminoglycol-modified silicones, aminophenyl-modified silicones, and polysiloxane-oxyalkylene copolymers; and fluorine-based oils such as perfluorodecane, perfluorooctane, and perfluoropolyether.

[0025] Moisturizing agents and texture improvers include polyols and their polymers such as glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, ethylene glycol-propylene glycol copolymer, and erythritan; glycol alkyl ethers such as diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, and diethylene glycol dibutyl ether; water-soluble esters such as polyglyceryl-10 (eicosane diacid / tetradecanedioic acid), polyglyceryl-10 tetradecanedioic acid, and bisethoxydiglycol cyclohexanedicarboxylate; and sugar alcohols such as sorbitol, xylitol, erythritol, mannitol, and maltitol. glucose, fructose, galactose, mannose, threose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, trehalose, glucosyltrehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins (α-, β-, γ-cyclodextrin, and modified cyclodextrins such as maltosylated and hydroxyalkylated), β-glucan, chitin, chitosan, heparin and derivatives, pectin, arabinogalactan, dextrin, dextrin, Sugars and their derivatives, such as orchid, glycogen, ethyl glucoside, glucosyl ethyl methacrylate polymer or copolymer; hyaluronic acid, sodium hyaluronate; sodium chondroitin sulfate; mucoitin sulfate, caronin sulfate, keratosulfate, dermatan sulfate; Tremella fuciformis extract, Tremella fuciformis polysaccharide; fructans, such as inulin and levan; fucoidan; tuberose polysaccharide, naturally occurring polysaccharides; organic acids, such as citric acid, tartaric acid, lactic acid, and their salts; urea; 2-pyrrolidone-5-carboxylic acid and its sodium salts, etc.;Amino acids and their salts, such as betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, tryptophan, histidine, taurine, γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid, carnitine, carnosine, and creatine; collagen, fish-derived collagen, atelocollagen, gelatin, elastin, collagen hydrolysis peptides, hydrolyzed collagen, hydroxypropylammonium chloride hydrolysis collagen, elastin hydrolysis peptides, keratin hydrolysis peptides, hydrolyzed keratin, conchiolin hydrolysis peptides, hydrolyzed conchiolin, silk protein hydrolysis peptides, hydrolyzed silk, sodium lauroyl hydrolyzed silk, soy protein hydrolysis peptides, small Protein peptides and their derivatives such as wheat proteolysis peptides, hydrolyzed wheat protein, casein hydrolysis peptides, and acylated peptides; acylated peptides such as palmitoyl oligopeptide, palmitoyl pentapeptide, and palmitoyl tetrapeptide; silylated peptides; lactic acid bacteria culture liquid, yeast extract, eggshell membrane protein, bovine submandibular gland mucin, hypotaurine, sesame lignan glycoside, glutathione, albumin, whey; choline chloride, phosphorylcholine; placenta extract, air Preferred examples of the active ingredient include animal and plant extracts such as lastin, collagen, aloe extract, witch hazel water, loofah water, chamomile extract, licorice extract, comfrey extract, silk extract, rose roe extract, yarrow extract, eucalyptus extract, and melilot extract, and ceramides such as natural ceramides (types 1, 2, 3, 4, 5, and 6), hydroxyceramides, pseudoceramides, sphingoglycolipids, ceramides, and glycoceramide-containing extracts.

[0026] Preferred examples of surfactants include anionic surfactants, nonionic surfactants, cationic surfactants, amphoteric surfactants, and polymer surfactants. There is no particular limitation on the HLB of the surfactant, and surfactants with a low HLB of about 1 to a high HLB of about 20 can be used, and it is also preferable to combine surfactants with low and high HLB. Preferred examples of surfactants include anionic surfactants such as fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfate ester salts such as sodium lauryl sulfate, triethanolamine lauryl sulfate, and ammonium lauryl sulfate; polyoxyethylene alkyl sulfate salts such as sodium laureth sulfate and triethanolamine laureth sulfate; acyl N-methyl amino acid salts such as sodium cocoyl methyl taurate, potassium cocoyl methyl taurate, sodium lauroyl methyl taurate, sodium myristoyl methyl taurate, sodium lauroyl methyl alanine, sodium lauroyl sarcosine, triethanolamine lauroyl sarcosine, and sodium lauroyl glutamate methyl alanine; sodium cocoyl glutamate, triethanolamine cocoyl glutamate, and sodium lauroyl glutamate. Acyl amino acid salts such as sodium myristoyl glutamate, sodium stearoyl glutamate, palmitoyl aspartic acid ditriethanolamine, cocoyl alanine triethanolamine, and sodium dilauroyl glutamate lysine; polyoxyethylene alkyl ether acetates such as sodium laureth acetate; succinic acid ester salts such as sodium lauroyl monoethanolamide succinate; fatty acid alkanolamide ether carboxylates; acyl lactates; polyoxyethylene fatty amine sulfates; fatty acid alkanolamide sulfates; fatty acid glyceride sulfates such as sodium hydrogenated coconut oil fatty acid glycerin sulfate; alkyl benzene polyoxyethylene sulfates; olefin sulfonates such as sodium α-olefin sulfonate; alkyl sulfosuccinates such as disodium lauryl sulfosuccinate and dioctyl sodium sulfosuccinate;alkyl ether sulfosuccinates such as disodium laureth sulfosuccinate, sodium monolauroyl monoethanolamide polyoxyethylene sulfosuccinate, sodium lauryl polypropylene glycol sulfosuccinate; alkyl benzene sulfonates such as sodium tetradecylbenzene sulfonate, triethanolamine tetradecylbenzene sulfonate; alkyl naphthalene sulfonates; alkane sulfonates; α-sulfofatty acid methyl ester salts; acyl isethionates; alkyl glycidyl ether sulfonates; alkyl sulfoacetates; alkyl ether phosphate salts such as sodium laureth phosphate, sodium dilaureth phosphate, sodium trilaureth phosphate, sodium monoolethate; alkyl phosphate salts such as potassium lauryl phosphate; sodium caseinate; alkyl aryl ether phosphate salts; fatty acid amide ether phosphate salts; phospholipids such as phosphatidylglycerol, phosphatidylinositol, phosphatidic acid, cyclic lysophosphatidic acid or salts thereof; silicones such as carboxylic acid modified silicones, phosphate modified silicones, and sulfate modified silicones. ricone-based anionic surfactants, etc.; nonionic surfactants include polyoxyethylene alkyl ethers with various polyoxyethylene addition numbers, such as laureths (polyoxyethylene lauryl ethers), ceteths (polyoxyethylene cetyl ethers), steareths (polyoxyethylene stearyl ethers), beheneths (polyoxyethylene behenyl ethers), isosteareths (polyoxyethylene isostearyl ethers), and octyldodeceths (polyoxyethylene octyldodecyl ethers); polyoxyethylene alkyl phenyl ethers. esters; castor oil and hydrogenated castor oil derivatives such as polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearate diester, and polyoxyethylene hydrogenated castor oil maleic acid; polyoxyethylene phytosterols; polyoxyethylene cholesterol; polyoxyethylene cholestanol; polyoxyethylene lanolin; polyoxyethylene reduced lanolin;Polyoxyethylene-polyoxypropylene cetyl ether, polyoxyethylene-polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene-polyoxypropylene monobutyl ether, polyoxyethylene-polyoxypropylene hydrogenated lanolin, polyoxyethylene-polyoxypropylene glycerin ether, etc. Polyoxyethylene-polyoxypropylene alkyl ethers; polyoxyethylene-polyoxypropylene glycol; PPG-9 diglyceryl, etc. ) Glycerin polyoxypropylene glycol; glyceryl stearate, glyceryl isostearate, glyceryl palmitate, glyceryl myristate, glyceryl oleate, glyceryl coconut oil fatty acid, glyceryl monocottonseed oil fatty acid, glyceryl monoerucate, glyceryl sesquioleate, glyceryl α,α'-oleate pyroglutamate, glyceryl monostearate malate, and other glycerin fatty acid partial esters; polyglyceryl-2, 3, 4, 5, 6, and 8 stearate , 10, polyglyceryl-6 distearate, 10, polyglyceryl-2 tristearate, polyglyceryl-10 deca stearate, polyglyceryl-2 isostearate, 3, 4, 5, 6, 8, 10, polyglyceryl-2 diisostearate (diglyceryl diisostearate), 3, 10, polyglyceryl-2 triisostearate, polyglyceryl-2 tetraisostearate, polyglyceryl-10 decaisostearate, polyglyceryl-2 oleate, 3, No. 4, No. 5, No. 6, No. 8, No. 10, polyglycerin fatty acid esters such as polyglyceryl-6 dioleate, polyglyceryl-2 trioleate, and polyglyceryl-10 decaoleate; ethylene glycol mono fatty acid esters such as ethylene glycol monostearate; propylene glycol mono fatty acid esters such as propylene glycol monostearate; pentaerythritol partial fatty acid esters; sorbitol partial fatty acid esters; maltitol partial fatty acid esters; maltitol ethers;Sorbitan fatty acid esters such as sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexylate, and diglycerol sorbitan tetra-2-ethylhexylate; sucrose fatty acid esters such as sucrose laurate, sucrose myristate, sucrose palmitate, sucrose dilaurate, sucrose dimyristate, and sucrose dipalmitate. Partial esters of sugar derivatives such as glyceryl, methyl glucoside fatty acid esters, and trehalose undecylenate; alkyl glucosides such as caprylyl glucoside; alkyl polyglycosides; glycolipids such as mannosyl erythritol lipid; lanolin alcohol; reduced lanolin; polyoxyethylene distearate, polyethylene glycol diisostearate, polyoxyethylene monooleate, polyoxyethylene dioleate, and other polyoxyethylene fatty acid mono- and diesters; polyoxyethylene propylene glycol fatty acid esters; polyoxyethylene glycol Polyoxyethylene glycerin fatty acid esters such as polyoxyethylene monooleates such as serine monostearate, polyoxyethylene glycerin monoisostearate, and polyoxyethylene glycerin triisostearate; polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, and polyoxyethylene sorbitan tetraoleate; polyoxyethylene sorbitol fatty acid esters such as polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate, polyoxyethylene sorbitol pentaoleate, and polyoxyethylene sorbitol monostearate; polyoxyethylene methyl glucoside fatty acid esters; polyoxyethylene alkyl ether fatty acid esters; polyoxyethylene sorbitol beeswax and other polyoxyethylene animal and vegetable oils and fats; isostearyl glyceryl ether, alkyl glyceryl ethers such as chimyl alcohol, selachyl alcohol, and batyl alcohol; polyhydric alcohol alkyl ethers;Polyoxyethylene alkylamines; tetrapolyoxyethylene-tetrapolyoxypropylene-ethylenediamine condensates; natural surfactants such as saponin, surfactin, rhamnolipid, sophorolipid, etc.; polyoxyethylene fatty acid amides; coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid Fatty acid alkanolamides such as palmitic acid monoethanolamide (paltamide MEA), palmitic acid diethanolamide (paltamide DEA), coconut oil fatty acid methylethanolamide (cocamide methyl MEA); alkyl dimethylamine oxides such as lauramine oxide, cocamine oxide, stearamine oxide, behenamine oxide; alkyl ethoxydimethylamine oxide; polyoxyethylene alkyl mercaptan; polyether modified silicones such as dimethicone copolyol, polysiloxane-oxyalkylene copolymers, polyglycerin modified Silicone-based nonionic surfactants such as silicone and sugar-modified silicone; cationic surfactants include alkyltrimethylammonium chlorides such as behentrimonium chloride, steartrimonium chloride, cetrimonium chloride, and lauryltrimonium chloride; alkyltrimethylammonium bromides such as stearyltrimonium bromide; dialkyldimethylammonium chlorides such as distearyldimonium chloride and dicocodimonium chloride; fatty acid amidoamines and their salts such as stearamidopropyl dimethylamine and stearamidoethyl diethylamine; alkyl ether amines and their salts or quaternary salts such as stearoxypropyl dimethylamine; fatty acid amide-type quaternary ammonium salts such as ethyl sulfate long-chain branched fatty acid (12-31) aminopropyl ethyl dimethyl ammonium and ethyl sulfate lanolin fatty acid aminopropyl ethyl dimethyl ammonium; polyoxyethylene alkylamines and their salts or quaternary salts; alkylamine salts; fatty acid amide guanidinium salts; alkyl ether amine monium salts; alkyl trialkylene glycol ammonium salts; benzalkonium salts;benzethonium salts; pyridinium salts such as cetylpyridinium chloride; imidazolinium salts; alkylisoquinolinium salts; dialkylmorphonium salts; polyamine fatty acid derivatives; silicone-based cationic surfactants such as amino-modified silicones such as aminopropyl dimethicone and amodimethicone, cation-modified silicones, cation-modified and polyether-modified silicones, and amino-modified and polyether-modified silicones; amphoteric surfactants include N-alkyl-N,N-dimethyl amino acid betaines such as lauryl betaine (lauryl dimethyl amino acetate betaine); fatty acid amidoalkyl-N,N-dimethyl amino acid betaines such as cocamidopropyl betaine and lauramidopropyl betaine; imidazoline-type betaines such as sodium cocoamphoacetate and sodium lauroamphoacetate; betaines such as alkyldimethyltaurine; sulfate type betaines such as alkyldimethylaminoethanol sulfate ester; phosphate type betaines such as alkyldimethylaminoethanol phosphate ester; sphingophospholipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin, phospholipids such as lysolecithin, hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, partially hydrogenated egg yolk phospholipid, and hydroxide lecithin; silicone-based amphoteric surfactants, etc.; and among the polymer surfactants, preferred examples include polyvinyl alcohol, sodium alginate, starch derivatives, tragacanth gum, and acrylic acid / alkyl methacrylate copolymers; and various silicone-based surfactants.

[0027] Polymers, thickeners, and gelling agents include guar gum, locust bean gum, queen seed, carrageenan, galactan, gum arabic, tara gum, tamarind, furcellan, karaya gum, aoi, caragam, tragacanth gum, pectin, pectinic acid and its salts, alginic acid and its salts, mannan; starches such as rice, corn, potato, and wheat; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salts, xanthan gum, pullulan, gellan gum, chitin, chitosan, etc. cellulose, agar, cassou extract, chondroitin sulfate, casein, collagen, gelatin, albumin; methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, carboxymethylcellulose and its sodium salts, methylhydroxypropylcellulose, carboxylated cellulose nanofiber, carboxymethylcellulose nanofiber, phosphated cellulose nanofiber, sulfonated cellulose nanofiber, sodium cellulose sulfate, dialkyldimethylammonium sulfate cellulose and its derivatives such as cellulose acetate, crystalline cellulose, cellulose powder; starch-based polymers such as soluble starch, carboxymethyl starch, methyl hydroxypropyl starch, methyl starch, starch derivatives such as hydroxypropyltrimonium starch chloride, corn starch aluminum octenyl succinate; alginic acid derivatives such as sodium alginate and propylene glycol alginate; polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), vinylpyrrolidone-vinyl alcohol copolymer, polyvinyl methyl ether; polyethylene glycol, polypropylene glycol, polyoxyethylene-polyoxypropylene copolymer; amphoteric methacrylate copolymers such as (methacryloyloxyethyl carboxybetaine / alkyl methacrylate) copolymer, (acrylates / stearyl acrylate / ethylamine oxide methacrylate) copolymer; (dimethicone / vinyl dimethicone) crosspolymer, (alkyl acrylate / diacetone acrylamide) copolymer, (alkyl acrylate / diacetone acrylamide) copolymer AMP;Partially saponified polyvinyl acetate, maleic acid copolymer; vinylpyrrolidone-dialkylaminoalkyl methacrylate copolymer; acrylic resin alkanolamine; polyester, water-dispersible polyester; polyacrylamide; polyacrylic acid ester copolymers such as polyethyl acrylate, carboxyvinyl polymer, polyacrylic acid and its sodium salt, acrylic acid-methacrylic acid ester copolymer; acrylic acid-alkyl methacrylate copolymer; cationized cellulose such as polyquaternium-10, diallyldimethylammonium chloride-acrylamide copolymer such as polyquaternium-7, acrylic acid-diallyldimethylammonium chloride copolymer such as polyquaternium-22, acrylic acid-diallyldimethylammonium chloride-acrylamide copolymer such as polyquaternium-39, acrylic acid-cationized methacrylic acid ester copolymer, acrylic acid-cationized methacrylic acid amide copolymer, acrylic acid-cationized methacrylic acid amide copolymer, acrylic acid-47 ... copolymer of methacrylic acid, methyl acrylate, methacrylamidopropyltrimethylammonium chloride, polymer of choline ester of methacrylic acid chloride; cationic oligosaccharides, cationic dextran, cationic polysaccharides such as guar hydroxypropyltrimonium chloride; polyethyleneimine; cationic polymers; polymers of 2-methacryloyloxyethyl phosphorylcholine such as polyquaternium-51 and copolymers with butyl methacrylate copolymers; acrylic resin emulsions, polyethyl acrylate emulsions, polyacrylic alkyl ester emulsions, polyvinyl acetate resin emulsions, natural rubber latex, synthetic latex and other polymer emulsions; nitrocellulose; polyurethanes and various copolymers; various silicones; various silicone-based copolymers such as acrylic-silicone graft copolymers; various fluorine-based polymers; 12-hydroxystearic acid and its salts; dextrin fatty acid esters such as dextrin palmitate and dextrin myristate;Preferred examples include anhydrous silicic acid, fumed silica (ultrafine particle anhydrous silicic acid), aluminum magnesium silicate, sodium magnesium silicate, metal soap, dialkyl phosphate metal salt, bentonite, hectorite, organically modified clay minerals, sucrose fatty acid esters, and fructooligosaccharide fatty acid esters.

[0028] The antioxidants preferably include tocopherol derivatives such as tocopherol (vitamin E) and tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; vitamin C (ascorbic acid) and / or its derivatives; erythorbic acid and its derivatives; sulfites such as sodium sulfite; hydrogen sulfites such as sodium hydrogen sulfite; thiosulfates such as sodium thiosulfate; metabisulfites; thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, and cysteine ​​hydrochloride. The reducing agents preferably include thioglycolic acid, cysteine, and cysteamine. The oxidizing agents preferably include hydrogen peroxide, ammonium persulfate, sodium bromate, and percarbonate. Examples of antioxidants include ascorbic acid, ascorbic acid phosphate salts such as sodium ascorbic acid phosphate and magnesium ascorbic acid phosphate; ascorbic acid fatty acid esters such as monostearate ascorbic acid, monopalmitate ascorbic acid, dipalmitate ascorbic acid, and tetraisopalmitate ascorbic acid; ascorbic acid ethers such as 3-O-ethyl ascorbic acid, 2-O-ethyl ascorbic acid, cetyl ascorbic acid, glyceryl ascorbic acid, and hexylglyceryl ascorbic acid; ascorbic acid glucoside and its fatty acid esters such as ascorbic acid-2-glucoside; Preferred examples of the vitamin A derivatives include ascorbic acid derivatives such as tocopheryl ascorbyl phosphate and tocopheryl ascorbyl phosphate; vitamin A derivatives such as retinol, retinol acetate, retinol palmitate, and hydrogenated retinol; vitamin E derivatives such as tocopherol, tocopherol acetate, and tocotrienol; carotenoids such as carotene, lycopene, astaxanthin, and lutein; polyphenols such as phlorotannin, curcumin, anthocyanin, proanthocyanin, catechin, ellagic acid, quercetin, and apple polyphenol; coenzyme Q10, lipoic acid, lactoferrin, sesamin, hesperidin, protoanthocyanidin, lignan, chlorogenic acid, rutin, fullerene, and platinum nanocolloid.

[0029] Examples of the whitening agent include hydroquinone glycosides and esters thereof, such as arbutin and α-arbutin; ascorbic acid, ascorbic acid phosphate salts, such as sodium ascorbic acid phosphate and magnesium ascorbic acid phosphate; ascorbic acid fatty acid esters, such as ascorbic acid monostearate, ascorbic acid monopalmitate, ascorbic acid dipalmitate, and ascorbic acid tetraisopalmitate; ascorbic acid esters, such as 3-O-ethyl ascorbic acid, 2-O-ethyl ascorbic acid, cetyl ascorbic acid, glyceryl ascorbic acid, and hexylglyceryl ascorbic acid; ascorbic acid glucoside and its fatty acid esters, such as ascorbic acid sulfate and tocopheryl ascorbyl phosphate; tranexamic acid derivatives, such as tranexamic acid, cetyl tranexamate, and tranexamic acid amide; licorice extract-related substances, such as glabridin, glabrene, liquiritin, and isoliquiritin; and plant extracts, such as kojic acid, ellagic acid, ferulic acid and their derivatives, placenta extract, glutathione, oryzanol, butylresorcinol, oil-soluble chamomilla extract, oil-soluble licorice extract, Nishikawa willow extract, and saxifrage extract, are preferred.

[0030] Vitamins and their derivatives include vitamin A such as retinol, retinol acetate, and retinol palmitate; vitamin B such as thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine dipalmitate, flavin adenine dinucleotide, cyanocobalamin, folic acids, nicotinic acids such as nicotinamide and benzyl nicotinate, and choline; vitamin C such as ascorbic acid and its sodium salts; vitamin D; vitamin E such as α-, β-, γ-, and δ-tocopherol; other vitamins such as pantothenic acid and biotin; and vitamin B such as sodium ascorbic acid phosphate and magnesium ascorbic acid phosphate. Preferred examples of the compound include ascorbic acid phosphate salts, ascorbic acid fatty acid esters such as ascorbic acid tetraisopalmitate, ascorbyl stearate, ascorbyl palmitate, ascorbyl dipalmitate, etc., ascorbic acid alkyl ethers such as ascorbic acid ethyl ether, ascorbic acid glucoside and its fatty acid esters such as ascorbic acid-2-glucoside, and ascorbic acid derivatives such as tocopheryl ascorbyl phosphate; vitamin derivatives such as tocopherol nicotinate, tocopherol acetate, tocopherol linoleate, tocopherol ferulate, tocopherol phosphate, etc., tocotrienol, and various other vitamin derivatives.

[0031] Plant, animal and microbial extracts include iris extract, angelica extract, asparagus extract, avocado extract, amacha extract, almond extract, althea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo extract, inchiko extract, fennel extract, turmeric extract, oolong tea extract, uva-ursi extract, angelica extract, echinacea leaf extract, enmeiso extract, scutellaria extract, phellodendron bark extract, coptis extract, barley extract, ginseng extract, hypericum extract, and nettle extract. Sow extract, Ononis extract, Dutch mustard extract, Orange extract, Seawater dried product, Seaweed extract, Oyster leaf extract, Kakyoku extract, Hydrolyzed elastin, Hydrolyzed wheat powder, Hydrolyzed silk, Pueraria root extract, Chamomilla extract, Oil-soluble Chamomilla extract, Carrot extract, Artemisia capillaris extract, Oat extract, Karkade extract, Licorice extract, Oil-soluble Licorice extract, Kiwi extract, Kiou extract, Jew's ear extract, Cinchona extract, Cucumber extract, Paulownia leaf extract, Guanosine, Guava extract, Sophora root extract, Gardenia extract, Sasa veitchii extract, Sophora flavonoides extract, walnut extract, chestnut extract, grapefruit extract, clematis extract, black rice extract, brown sugar extract, black vinegar extract, chlorella extract, mulberry extract, gentiana extract, geranium extract, black tea extract, yeast extract, magnolia bark extract, coffee extract, burdock extract, rice extract, fermented rice extract, fermented rice bran extract, rice germ oil, comfrey extract, collagen, cowberry extract, Chinese laurel extract, bupleurum extract, umbilical cord extract, umbilical cord extract, saffron extract, salvia extract, soapwort extract, bamboo grass extract, hawthorn extract, sanschae Japanese flounder, Japanese pepper extract, shiitake mushroom extract, rehmannia extract, lithospermum extract, perilla extract, linden extract, meadowsweet extract, jatoba extract, peony extract, angelica extract, calamus root extract, white birch extract, white wood ear extract, horsetail extract, stevia extract, stevia fermentation product, Nishikawa willow extract, ivy extract, hawthorn extract, elderberry extract, yarrow extract, peppermint extract, sage extract, mallow extract, cnidium rhizome extract, swertia britannica extract, sophora japonica extract, rhubarb extract,Soybean extract, Chinese laurel extract, thyme extract, dandelion extract, lichen extract, tea extract, clove extract, Imperata cylindrica extract, tangerine extract, tea tree oil, sweet tea extract, chili pepper extract, angelica extract, calendula extract, toad extract, spruce extract, dokudami extract, tomato extract, natto extract, carrot extract, garlic extract, wild rose extract, hibiscus extract, burdock extract, lotus extract, parsley extract, birch extract, honey, witch hazel extract, parietaria extract, yarrow extract, bisabolol, cypress extract, bifidobacteria extract, loquat extract, coltsfoot extract, butterbur bud extract, bupleurum extract, butcher's broom extract, grape extract, grape seed extract Preferred examples of the extract include whiting, propolis, loofah extract, safflower extract, peppermint extract, linden extract, peony extract, hop extract, squid extract, pine extract, horse chestnut extract, skunk cabbage extract, soapberry extract, melissa extract, mozuku extract, peach extract, cornflower extract, eucalyptus extract, saxifrage extract, yuzu extract, lily extract, coix seed extract, mugwort extract, lavender extract, green tea extract, eggshell membrane extract, apple extract, rooibos tea extract, lychee extract, lettuce extract, lemon extract, forsythia extract, astragalus extract, rose extract, rosemary extract, Roman chamomile extract, royal jelly extract, and burnet extract.

[0032] Examples of ultraviolet absorbents include benzoic acid-based ultraviolet absorbents such as para-aminobenzoic acid, para-aminobenzoic acid monoglycerin ester, N,N-dipropoxy para-aminobenzoic acid ethyl ester, N,N-diethoxy para-aminobenzoic acid ethyl ester, N,N-dimethyl para-aminobenzoic acid ethyl ester, N,N-dimethyl para-aminobenzoic acid butyl ester, and N,N-dimethyl para-aminobenzoic acid ethyl ester; anthranilic acid-based ultraviolet absorbents such as homomenthyl-N-acetylanthranilate; salicylic acid-based ultraviolet absorbents such as salicylic acid and its sodium salt, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, and p-isopropanol phenyl salicylate; octyl cinnamate, Cinnamic acid-based ultraviolet absorbers such as ethyl-4-isopropylcinnamate, methyl-2,5-diisopropylcinnamate, ethyl-2,4-diisopropylcinnamate, methyl-2,4-diisopropylcinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, 2-ethylhexyl-p-methoxycinnamate (octyl paramethoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate (cinoxate), cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl-α-cyano-β-phenylcinnamate (octocurin), glyceryl mono-2-ethylhexanoyl-di-paramethoxycinnamate, ferulic acid and its derivatives;Benzophenone UV absorbers such as 2,4-dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2,2',4,4'-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, and 4-hydroxy-3-carboxybenzophenone; 3-(4'-methylbenzylidene)-d,l-camphor, 3-benzylidene-d,l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5-methylphenylbenzotriazole; 2-(2'-hydro 2-(2'-hydroxy-5'-methylphenylbenzotriazole;Dibenzalazine;Dianisoylmethane;5-(3,3-dimethyl-2-norbornylidene)-3-pentan-2-one;Dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane;Octyltriazone;Urocanic acid and ethyl urocanate derivatives; ... Preferred examples thereof include hydantoin derivatives such as 1-(3,4-dimethoxyphenyl)-4,4-dimethyl-1,3-pentanedione, dimethoxybenzylidene dioxoimidazolidinepropionate 2-ethylhexyl, phenylbenzimidazolazole sulfonic acid, terephthalidenedicamphor sulfonic acid, drometrizole trisiloxane, methyl anthranilate, rutin and its derivatives, and oryzanol and its derivatives.

[0033] Antibacterial and preservative agents include parabens (hydroxybenzoic acid esters) such as methylparaben, ethylparaben, propylparaben, and butylparaben; phenoxyethanol; 1,2-alkanediols such as 1,2-pentanediol, 1,2-hexanediol, and 1,2-octanediol; alkyl glyceryl ethers such as 2-ethylhexylglyceryl ether (ethylhexylglycerin); salicylic acid; lanolin fatty acids and their salts; sodium benzoate; isothiazolinone derivatives such as methylchloroisothiazolinone and methylisothiazolinone; imidazolinium urea; dehydroacetic acid and its salts; phenols; halogenated bisphenols such as triclosan, acid amides, and quaternary ammonium salts; trichlorocarbanide, zinc pyrithione, and benzalkonium chloride. Preferred examples of the antibacterial agent include phenyl ether, benzethonium chloride, sorbic acid, chlorhexidine, chlorhexidine gluconate, halocarban, hexachlorophene, and hinokitiol; other phenols such as phenol, isopropylphenol, cresol, thymol, parachlorophenol, phenylphenol, and sodium phenylphenol; phenylethyl alcohol, photosensitizers, antibacterial zeolites, and silver ions. However, when used as an antibacterial agent or preservative for the purpose of preservation, it is more preferable to use phenoxyethanol; 1,2-alkanediols such as 1,2-pentanediol, 1,2-hexanediol, and 1,2-octanediol; and alkyl glyceryl ethers such as 2-ethylhexyl glyceryl ether, from the viewpoint of safety of the cosmetic or topical skin preparation.

[0034] Preferred examples of the chelating agent include edetates (ethylenediaminetetraacetates) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na; hydroxyethylethylenediaminetriacetates such as HEDTA3Na; pentetates (diethylenetriaminepentaacetate); phytic acid; phosphonic acids such as etidronic acid and salts thereof such as their sodium salts; sodium oxalate; polyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphoric acid; sodium citrate, citric acid, alanine, dihydroxyethylglycine, gluconic acid, ascorbic acid, succinic acid, and tartaric acid.

[0035] Preferred examples of the pH adjuster, acid, or alkali include citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, monoethanolamine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, sodium hydroxide, potassium hydroxide, aqueous ammonia, guanidine carbonate, and ammonium carbonate.

[0036] Solvents and propellants include lower alcohols such as ethanol, 2-propanol (isopropyl alcohol), butanol, and isobutyl alcohol; glycols such as propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, and isopentyl diol; diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, and diethylene glycol diethyl ether. Preferred examples of the propellant include glycol ethers such as propylene glycol monoethyl ether; glycol ether esters such as ethylene glycol monoethyl ether acetate, diethylene glycol monoethyl ether acetate, and propylene glycol monoethyl ether acetate; glycol esters such as diethoxyethyl succinate and ethylene glycol disuccinate; benzyl alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate, acetone, ethyl acetate, N-methylpyrrolidone; toluene; fluorocarbons, next-generation fluorocarbons; LPG, dimethyl ether, and carbon dioxide gas.

[0037] Examples of antipruritic agents include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, and substance-P inhibitors. Examples of keratin peeling and dissolving agents include salicylic acid, sulfur, resorcin, selenium sulfide, pyridoxine, and glycolic acid. Examples of antiperspirants include aluminum chlorohydrate, aluminum chloride, zinc oxide, and zinc paraphenolsulfonate. Examples of cooling agents include menthol and methyl salicylate. Examples of astringents include citric acid, tartaric acid, lactic acid, aluminum potassium sulfate, tannic acid, and caffeine. Examples of enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, and protease. Examples of nucleic acids include ribonucleic acid and its salts, deoxyribonucleic acid and its salts, and adenosine triphosphate disodium.

[0038] Preferred examples of the anti-inflammatory agent include glycyrrhizinic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid and its derivatives, azelaic acid and its derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednisone, diphedramine hydrochloride, chlorpheniramine maleate; and plant extracts such as peach leaf extract and mugwort leaf extract. Preferred examples of hair growth agents, blood circulation promoters, and stimulants include plant extracts and tinctures such as Swertia japonica extract, Capsicum tincture, Ginger tincture, Ginger extract, and Cantharis tincture; capsaicin, nonylic acid valenylamide, zingerone, ichthammol, tannic acid, borneol, cyclandelate, cinnarizine, tolazoline, acetylcholine, verapamil, cepharanthine, γ-oryzanol, cepharanthine, vitamin E, and derivatives such as tocopherol nicotinate and tocopherol acetate, γ-oryzanol, nicotinic acid, and derivatives such as nicotinamide, nicotinic acid benzyl ester, inositol hexanicotinate, and nicotine alcohol, allantoin, photosensitizer 301, photosensitizer 401, capronium chloride, pentadecanoic acid monoglyceride, flavanonol derivatives, stigmasterol or stigmastanol and its glycosides, and minoxidil. Preferred examples of hormones include estradiol, estrone, ethinylestradiol, cortisone, hydrocortisone, prednisone, and the like.

[0039] Anti-wrinkle and anti-aging agents include ascorbic acid, ascorbic acid phosphate salts such as sodium ascorbic acid phosphate and magnesium ascorbic acid phosphate; ascorbic acid fatty acid esters such as ascorbic acid monostearate, ascorbic acid monopalmitate, ascorbic acid dipalmitate, and ascorbic acid tetraisopalmitate; ascorbic acid ethers such as 3-O-ethyl ascorbic acid, 2-O-ethyl ascorbic acid, cetyl ascorbic acid, glyceryl ascorbic acid, and hexylglyceryl ascorbic acid; ascorbic acid glucoside and its fatty acid esters such as ascorbic acid 2-glucoside; and ascorbic acid derivatives such as ascorbic acid sulfate and tocopheryl ascorbyl phosphate. Preferred examples of the vitamin A derivatives include retinol, retinol acetate, retinol palmitate, and hydrogenated retinol; nicotinamide, glutathione, cysteine, crocetin, sericin, geraniol, glycerin glucoside, lactoferrin, proanthocyanin, pantothenic acid, panthenol, soybean saponin, revelastrol, isoflavone, coenzyme Q10, chondroitin sulfate, acetylglucosamine, glycerophosphatidylcholine, hydrolyzed hyaluronic acid, collagen peptide, conchiolin hydrolyzate, adenosine 5'-monophosphate, phosphatidylinositol, trifluoroisopropyloxopropylaminocarbonylpyrrolidinecarbonylmethylpropylaminocarbonylbenzoylaminoacetic acid Na, and tranexamic acid and derivatives thereof.

[0040] Preferred examples of the irritation alleviating agent include mannosylerythritol lipid, dimer dilinoleic acid diethylene glycol oligomer ester, diisostearyl malate, N-acyl-L-glutamic acid, trehalose mono fatty acid ester, fatty acid amidoamine oxide, alkyldimethylamine oxide, phenylethyl glucoside, lauryl glucoside, ferulic acid glucoside, salicin, cedrol, polyethylene glycol, polypropylene glycol, etc. Preferred examples of the cooling agent include menthol, camphor, menthyl lactate, monomenthyl succinate, menthyl acetate, borneol, cineol, thymol, peppermint oil, peppermint oil, and derivatives thereof. Preferred examples of the warming agent include vanillin and its derivatives, nonanoic acid vanillylamide, shogaol, gingerol, capsicum tincture, capsicum extract, nicotinic acid derivatives such as benzyl nicotinate, methyl nicotinate, phenyl nicotinate, and tocopherol nicotinate, capsaicin, watercress extract, Japanese pepper extract, ginger extract, and canthari extract.

[0041] Examples of powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, red mica, biotite, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, tungstate metal salts, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluorapatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, metal soap (e.g. zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, red iron oxide, yellow iron oxide, black iron oxide, ultramarine, Prussian blue, carbon black, titanium oxide, fine and ultrafine titanium oxide, zinc oxide, fine and ultrafine zinc oxide, alumina, silica, fumed silica (ultrafine silicic anhydride), titanium mica. Preferred examples of the inorganic powders include inorganic powders of various sizes and shapes, such as fish scale foil, boron nitride, photochromic pigments, synthetic fluorine-containing mica, fine particle composite powders, gold, and aluminum, and inorganic powders which have been treated with silicones such as hydrogen silicone and cyclic hydrogen silicone, or other silanes, or various surface treatment agents such as titanium coupling agents to make them hydrophobic or hydrophilic; organic powders of various sizes and shapes, such as starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, styrene-acrylic acid copolymer resin powder, polyester powder, benzoguanamine resin powder, polyethylene terephthalate-polymethyl methacrylate laminate powder, polyethylene terephthalate-aluminum-epoxy laminate powder, urethane powder, silicone powder, Teflon (registered trademark) powder, and surface-treated powders; and organic-inorganic composite powders.Preferred examples of the inorganic salts include sodium chloride-containing salts such as table salt, ordinary salt, rock salt, sea salt, and natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, ammonium chloride; sodium sulfate, aluminum sulfate, aluminum / potassium sulfate (alum), aluminum / ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, ferrous sulfate, and copper sulfate; and sodium phosphates such as 1Na / 2Na / 3Na phosphate, potassium phosphates, calcium phosphates, and magnesium phosphates.

[0042] Dyes, colorants, dyes and pigments include Brown No. 201, Black No. 401, Purple No. 201, Purple No. 401, Blue No. 1, Blue No. 2, Blue No. 201, Blue No. 202, Blue No. 203, Blue No. 204, Blue No. 205, Blue No. 403, Blue No. 404, Green No. 3, Green No. 201, Green No. 202, Green No. 204, Green No. 205, Green No. 3, Green No. 401, Green No. 402 No., Red No. 102, Red No. 104-1, Red No. 105-1, Red No. 106, Red No. 2, Red No. 3, Red No. 201, Red No. 202, Red No. 203, Red No. 204, Red No. 205, Red No. 206, Red No. 207, Red No. 208, Red No. 213, Red No. 214, Red No. 215, Red No. 218, Red No. 219, Red No. 220, Red No. 221, Red No. 223 , Red No. 225, Red No. 226, Red No. 227, Red No. 228, Red No. 230-1, Red No. 230-2, Red No. 231, Red No. 232, Red No. 3, Red No. 401, Red No. 40 No. 4, Red No. 405, Red No. 501, Red No. 502, Red No. 503, Red No. 504, Red No. 505, Red No. 506, Orange No. 201, Orange No. 203, Orange No. 204, Orange 20 Legal dyes such as No. 5, Orange 206, Orange 207, Orange 401, Orange 402, Orange 403, Yellow 201, Yellow 202-1, Yellow 202-2, Yellow 203, Yellow 204, Yellow 205, Yellow 4, Yellow 401, Yellow 402, Yellow 403-1, Yellow 404, Yellow 405, Yellow 406, Yellow 407, Yellow 5, etc.; Acid Other acid dyes such as Red 14; basic dyes such as Arianor Sienna Brown, Arianor Madder Red, Arianor Steel Blue, Arianor Straw Yellow; nitro dyes such as HC Yellow 2, HC Yellow 5, HC Red 3, 4-hydroxypropylamino-3-nitrophenol, N,N'-bis(2-hydroxyethyl)-2-nitro-p-phenylenediamine, HC Blue 2, Basic Blue 26; disperse dyes; inorganic white pigments such as titanium dioxide and zinc oxide; inorganic red pigments such as iron oxide (red iron oxide) and iron titanate; inorganic brown pigments such as gamma-iron oxide; inorganic yellow pigments such as yellow iron oxide and ochre; inorganic black pigments such as black iron oxide and low-order titanium oxide;Inorganic purple pigments such as mango violet and cobalt violet; inorganic green pigments such as chromium oxide, chromium hydroxide, and cobalt titanate; inorganic blue pigments such as ultramarine and Prussian blue; pearl pigments such as titanium dioxide coated mica, titanium dioxide coated bismuth oxychloride, titanium dioxide coated talc, colored titanium dioxide coated mica, bismuth oxychloride, and fish scale foil; metal powder pigments such as aluminum powder, copper powder, and gold; anthraquinones such as astaxanthin and alizarin, anthocyanidins, β-carotene, catenal, capsanthin, chalcone, carthamine, and quercetin. Preferred examples of such dyes include naphthoquinones such as tin, crocin, chlorophyll, curcumin, cochineal, and shikonin, bixin, flavones, betacyanidin, henna, hemoglobin, lycopene, riboflavin, and rutin; oxidation dye intermediates and couplers such as p-phenylenediamine, toluene-2,5-diamine, o-, m-, or p-aminophenol, m-phenylenediamine, 5-amino-2-methylphenol, resorcin, 1-naphthol, 2,6-diaminopyridine, and salts thereof; autoxidation dyes such as indoline; and dihydroxyacetone.

[0043] Fragrances include acetyl cedrene, amyl cinnamaldehyde, allyl amyl glycolate, β-ionone, isoe-super, isobutylquinoline, iris oil, iron, indole, ylang-ylang oil, undecanal, undecenal, γ-undecalactone, estragole, eugenol, oakmoss, opoponax resinoid, orange oil, eugenol, aurantiol, galacsolid, carvacrol, L-carvone, camphor, canon, carrot seed oil, clove oil, methyl cinnamate, geraniol, geranyl nitrile, isobornyl acetate, geranyl acetate, dimethylbenzylcarbinyl acetate, styralyl acetate, cedryl acetate, terpinel acetate, pt-butylcyclohexyl acetate. , vetiveryl acetate, benzyl acetate, linalyl acetate, isopentyl salicylate, benzyl salicylate, sandalwood oil, santalol, cyclamen aldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromyrcenol, jasmine absolute, jasmine lactone, cis-jasmone, citral, citronenol, citronellal, cinnamon bark oil, 1,8-cineole, cinnamaldehyde, styrax resinoids, cedarwood oil, cedrene, cedrol, celery seed oil, thyme oil, damascone, damascenone, thymol, tuberose absolute, decanal, decalactone, terpineol, gamma-terpinene, triplal, nerol, nonanal, 2,6-Nonadienol, Nonalactone, Patchouli Alcohol, Vanilla Absolute, Vanillin, Basil Oil, Patchouli Oil, Hydroxycitronellal, Alpha-Pinene, Piperitone, Phenethyl Alcohol, Phenylacetaldehyde, Petitgrain Oil, Hexylcinnamaldehyde, cis-3-Hexenol, Balsam of Peru, Vetiver Oil, Vetiverol, Peppermint Oil, Pepper Oil, Heliotropin, Bergamot Oil, Benzyl Benzene Preferred examples of the synthetic and natural fragrances include maltitol, borneol, myrrhizinoid, musk ketone, methylnonylacetaldehyde, γ-methylionone, menthol, L-menthol, L-menthone, eucalyptus oil, β-ionone, lime oil, lavender oil, D-limonene, linalool, lyral, lilial, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, and various essential oils, as well as various blended fragrances.

[0044] Preferred examples of water include ordinary water, purified water, hard water, soft water, natural water, deep sea water, electrolytic alkaline ionized water, electrolytic acidic ionized water, ionized water, and cluster water.

[0045] In addition to the above, it is possible to contain known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc. in known combinations, ratios, and amounts, such as ingredients listed in the Cosmetic Raw Materials Standards, Cosmetic Type Ingredient Standards, Japan Cosmetic Industry Association Ingredient Labeling Name List, INCI Dictionary (The International Cosmetic Ingredient Dictionary and Handbook), Quasi-drug Raw Materials Standards, Japanese Pharmacopoeia, Pharmaceutical Additives Standards, Food Additives Official Compendium, etc., and ingredients listed in Japanese and foreign patent gazettes and patent publications (including published gazettes and republications) that belong to the International Patent Classification IPC classifications A61K7 and A61K8.

[0046] The types of the cosmetic of the present invention include hair cosmetics, skin cosmetics, make-up cosmetics, fragrance cosmetics, body cosmetics, etc. The cosmetic of the present invention can be produced according to a conventional method.

[0047] To explain the types of cosmetics of the present invention in more detail, preferred examples of hair cosmetics include shampoos such as oil shampoo, cream shampoo, conditioning shampoo, anti-dandruff shampoo, hair color shampoo, and rinse-integrated shampoo; hair care agents such as rinse, conditioner, treatment, hair pack, leave-on treatment, hair mist, and hair oil; hair styling products such as hair foam, hair mousse, hair spray, hair wax, hair gel, hair cream, water grease, setting lotion, pomade, and hair styling products; hair dyes such as color lotions, hair color treatments, hair manicures, and oxidation hair dyes; hair tonics, hair liquids, hair blow dryers, split end coats, permanent wave agents, straight perm agents, hair bleach, hair color pre-treatments, hair color after-treatments, perm pre-treatments, perm after-treatments, and hair growth agents.

[0048] Skin cosmetics include lotions such as softening lotion, astringent lotion, cleansing lotion, multi-layered lotion, and liposome lotion; emulsions such as emollient lotion, moisture lotion, milky lotion, nourishing lotion, nourishing milk, skin moisture, moisturizing emulsion, massage lotion, exfoliating smoother, elbow lotion, hand lotion, and body lotion; emollient cream, nourishing cream, nourishing cream, vanishing cream, moisture cream, night cream, massage cream, cleansing cream, makeup cream, base cream, pre-makeup cream, sunscreen cream, suntan cream, hair removal cream, deodorant cream, shaving cream, keratin cream, etc. Preferred examples of the cosmetic products include skin care cosmetics such as creams such as softening cream, gels such as moisturizing gel, whitening gel, all-in-one gel, and beauty serums such as moisturizing essence, whitening essence, moisturizing serum, and whitening serum; sunscreen cosmetics such as sun protect, sun protector, UV care milk, and sunscreen; packs and masks such as peel-off pack, powder pack, washing pack, oil pack, and cleansing mask; cleansing cosmetics such as cleansing foam, cleansing cream, cleansing milk, cleansing lotion, cleansing gel, and cleansing oil; and facial cleansers such as paste facial foam, gel facial foam, foam facial foam, facial cleansing powder, cosmetic soap, transparent soap, medicated soap, liquid soap, and shaving soap.

[0049] Preferred examples of makeup cosmetics include lipstick, lip gloss, foundation, blush, face powder, concealer, eyeliner, mascara, eye shadow, eyebrow pencil, nail enamel, enamel remover, and nail treatment.

[0050] Preferred examples of the aromatic cosmetic include perfume, perfume, parfum, eau de parfum, eau de toilette, eau de cologne, perfume paste, aromatic powder, perfumed soap, body lotion, and bath oil.

[0051] Preferred examples of body cosmetics include body cleansers such as body shampoos, deodorant cosmetics such as deodorant lotions, deodorant powders, deodorant sprays and deodorant sticks, bleaches, depilatories, bath additives, and insect repellents such as insect repellent sprays.

[0052] Preferred types of the skin external preparation of the present invention include ointments, lotions, creams or gels for the skin, patches, liniments, liquid coatings, etc. They can also be used as oral cosmetic products such as toothpastes and mouthwashes.

[0053] Preferred dosage forms of the cosmetic or topical skin preparation of the present invention include emulsion-type cosmetics such as oil-in-water (O / W) type, water-in-oil (W / O) type, W / O / W type, and O / W / O type, oil-based cosmetics, solid cosmetics, liquid cosmetics, paste cosmetics, stick-type cosmetics, volatile oil-type cosmetics, powder cosmetics, jelly-type cosmetics, gel-type cosmetics, paste-type cosmetics, emulsified polymer-type cosmetics, sheet-type cosmetics, mist-type cosmetics, and spray-type cosmetics.

[0054] The present invention will be described in more detail with reference to the following examples, but the present invention is not limited to these examples in any way.

[0055] Water-dispersed compositions of the present invention and water-dispersed compositions outside the scope of the present invention were prepared according to the compositions shown in Tables 1 to 3. The transparency and dispersion stability of the obtained water-dispersed compositions were evaluated by the following methods, and the results are shown in the lower part of Tables 1 to 3. <Method for preparing water-dispersed composition> A polyhydric alcohol liquid was prepared by mixing components (A) and (B) at 80° C. The resulting polyhydric alcohol liquid was added to an aqueous solution of phenoxyethanol and component (C) that had been dissolved by heating at 80° C., while stirring, and the mixture was stirred with a homomixer (75° C., 5000 rpm, 15 minutes) and cooled. <Transparency evaluation method> The obtained water-dispersed composition was placed in a glass bottle having a diameter of 3.5 cm, and the appearance was visually observed from the side, and the transparency was evaluated according to the following evaluation criteria. ○ The liquid is clearly visible behind the surface △ The liquid is slightly visible behind × You can't see behind the liquid <Method for evaluating dispersion stability> The obtained aqueous dispersion composition was stored at 50° C. for 1 month, and then the appearance was visually observed, and the dispersion stability was evaluated according to the following evaluation criteria. 〇···No change in appearance from the initial state △... The appearance has changed slightly since the early days. ×...The appearance has changed significantly since the early days.

[0056] [Table 1]

[0057] [Table 2]

[0058] [Table 3]

[0059] A polyhydric alcohol liquid containing the components (A) and (B) of the present invention was prepared according to the composition shown in Table 4. Using the obtained polyhydric alcohol liquid, a water-dispersed composition was prepared according to the composition shown in Table 5. The transparency and dispersion stability of the obtained water-dispersed composition were evaluated by the same method as above, and the results are shown in the lower part of Table 5. <Method for preparing water-dispersed composition> The polyhydric alcohol solutions of Production Examples 1 to 5 were heated to 80° C. Thereafter, the polyhydric alcohol solutions were added with stirring to an aqueous solution of phenoxyethanol and component (C) that had been dissolved by heating at 80° C., and the mixture was stirred with a homomixer (75° C., 5000 rpm, 15 minutes) and cooled.

[0060] [Table 4]

[0061] [Table 5]

[0062] The results in Tables 1 to 3 and 5 show that the water-dispersed composition of the present invention has high transparency and excellent dispersion stability.

[0063] The following cosmetics were prepared. The skin cosmetics have excellent moisturizing properties and penetration, and prevent fine wrinkles and rough skin. The hair cosmetics have excellent moisturizing properties, penetration, and damage care effects. The makeup cosmetics have excellent moisturizing properties, adhesion to the skin, and smoothness.

[0064] Example 17 Water-dispersed composition Component Amount (wt%) -------------------------------------- Polyhydric alcohol solution of Production Example 1 20.0 Purified water (total amount is 100) -------------------------------------- (Preparation method) All ingredients were heated to 80°C, stirred with a homomixer (4500 rpm), and cooled to room temperature.

[0065] Example 18 Water-dispersed composition Component Amount (wt%) -------------------------------------- Part A Hydrogenated lecithin (PC content 76-99%) 5.0 Polyglyceryl-10 Laurate 5.0 Ceramide 6 2.0 1,2-Hexanediol 10.0 1,3-Butylene glycol 15.0 Part B Purified water (total amount is 100) -------------------------------------- (Preparation method) Part A and Part B were each heated to 80°C, and Part A was added to Part B while stirring with a homomixer (7000 rpm), followed by cooling to room temperature.

[0066] Example 19 Water-dispersed composition Component Amount (wt%) -------------------------------------- Part A Hydrogenated lecithin (PC content 50-75%) 4.0 Sucrose myristate 2.5 Ceramide 3 1.5 1,2-Hexanediol 10.0 1,3-Butylene glycol 5.0 Part B Methylparaben 0.2 Purified water (total amount is 100) -------------------------------------- (Preparation method) Part A and Part B were each heated to 70°C, and Part A was added to Part B while stirring with a homomixer (7000 rpm), followed by cooling to room temperature.

[0067] Example 20 Water-dispersed composition Component Amount (wt%) -------------------------------------- Part A Hydrogenated lecithin (PC content 76-99%) 3.5 Sucrose myristate 2.5 Ceramide 3 1.5 1,2-Hexanediol 10.0 1,3-Butylene glycol 5.0 Part B Phenoxyethanol 0.4 Purified water (total amount is 100) -------------------------------------- (Preparation method) Part A and Part B were each heated to 70°C, and Part A was added to Part B while stirring with a homomixer (7000 rpm), followed by cooling to room temperature.

[0068] Example 21 Water-dispersed composition Component Amount (wt%) -------------------------------------- Part A Hydrogenated lecithin (PC content 50-75%) 4.5 Polyglyceryl-10 Myristate 3.5 Ceramide 1 0.2 Ceramide 2 0.2 Ceramide 3 0.2 Ceramide 4 0.2 Ceramide 5 0.2 Ceramide 6 0.2 1,2-Hexanediol 10.0 1,3-Butylene glycol 10.0 Part B Phenoxyethanol 0.4 Purified water (total amount is 100) -------------------------------------- (Preparation method) Part A and Part B were each heated to 80°C, and Part A was added to Part B while stirring with a homomixer (7000 rpm), followed by cooling to room temperature.

[0069] Example 22 Water-dispersed composition Component Amount (wt%) -------------------------------------- Part A Hydrogenated lecithin (PC content 76-99%) 4.5 Polyglyceryl-10 Oleate 3.5 Ceramide 1 0.2 Ceramide 2 0.2 Ceramide 3 0.2 Ceramide 4 0.2 Ceramide 5 0.2 Ceramide 6 0.2 1,2-Hexanediol 10.0 1,3-Butylene glycol 10.0 Part B Phenoxyethanol 0.4 Purified water (total amount is 100) -------------------------------------- (Preparation method) Part A and Part B were each heated to 70°C, and Part A was added to Part B while stirring with a homomixer (7000 rpm), followed by cooling to room temperature.

[0070] Example 23 Water-dispersed composition Component Amount (wt%) -------------------------------------- Part A Hydrogenated lecithin (PC content 76-99%) 5.0 Polyglyceryl-10 Dimyristate 2.5 Ceramide 2 2.0 1,2-Hexanediol 10.0 1,3-Butylene glycol 10.0 Part B Purified water (total amount is 100) -------------------------------------- (Preparation method) Part A and Part B were each heated to 80°C, and Part A was added to Part B while stirring with a homomixer (7000 rpm), followed by cooling to room temperature.

[0071] Example 24 Lotion Component Amount (wt%) -------------------------------------- Water-dispersed composition of Example 10 20.0 Neosolue-Aqulio (Nippon Fine Chemicals) 1.0 Tremoist-TP (Nippon Fine Chemical) 0.1 Nicotinamide 5.0 Tranexamic acid (Nippon Fine Chemicals) 1.0 EDTA-2Na 0.05 Phenoxyethanol 0.4 Purified water (total amount is 100) -------------------------------------- (Preparation method) All ingredients were mixed to form a homogeneous liquid.

[0072] Example 25 Lotion Component Amount (wt%) -------------------------------------- Part A Hydrogenated lecithin (PC content 50-75%) 1.0 Sucrose laurate 0.3 Ceramide 6 0.2 Ascorbyl Tetraisopalmitate 1.0 Pyridoxine tris(hexyldecanoate) 0.1 1,3-Butylene glycol 5.0 1,2-Pentanediol 3.0 Part B Purified water (total amount is 100) C part Neosolue-Aqulio (Nippon Fine Chemicals) 1.0 Nicotinamide 5.0 Heparinoid 0.5 Glucosylceramide 0.5 Tremoist-TP (Nippon Fine Chemical) 0.1 EDTA-2Na 0.05 Phenoxyethanol 0.4 -------------------------------------- (Preparation method) Part A and Part B were each heated to about 80° C. Part A was added to Part B while stirring with a homogenizer (7000 rpm), and after cooling, Part C was added to make a homogenous liquid.

[0073] Example 26 Lotion Component Amount (wt%) -------------------------------------- Part A Hydrogenated lecithin (PC content 50-75%) 1.3 Sucrose oleate 0.4 Ceramide 3 0.1 1,2-Pentanediol 5.0 Part B Phenoxyethanol 0.4 Citric acid 0.2 Sodium citrate (appropriate amount) Purified water (total amount is 100) -------------------------------------- (Preparation method) Part A and Part B were heated to about 80°C. Part A was added to Part B while stirring with a homogenizer (7000 rpm). After cooling, Part C was added to make a homogenous liquid. Sodium citrate was added so that the pH was 6.5-7.0.

[0074] Example 27 Lotion Component Amount (wt%) -------------------------------------- Part A Hydrogenated lecithin (PC content 50-75%) 1.0 Polyglyceryl-10 Palmitate 1.5 Ceramide 1 0.6 Hexyl 3-glyceryl ascorbate 0.5 Myristyl 3-glyceryl ascorbate 0.5 3-Laurylglyceryl Ascorbate 0.5 1,3-Butylene glycol 10.0 Part B Purified water (total amount is 100) C part Carbomer 0.1 Arginine 0.1 Hydroxyethyl cellulose 0.2 Phenoxyethanol 0.4 Purified water 20.0 -------------------------------------- (Preparation method) Part A and Part B were heated to about 80°C. Part C was stirred to make a viscous liquid. Part A was added to Part B while stirring with a homogenizer (7000 rpm) to make a homogeneous liquid. After cooling, Part C was added to make a homogeneous liquid.

[0075] Example 28 Lotion Component Amount (wt%) ------------------------------------- Part A Hydrogenated lecithin (PC content 76-99%) 0.5 Polyglyceryl-5 Laurate 0.4 Ceramide 2 0.1 Diglycerin 1.0 Glycerin 8.0 1,3-Butylene glycol 3.0 Plandool-LG2 (Nippon Fine Chemicals) 0.001 Plandool-ISS (Nippon Fine Chemical) 0.005 Part B Purified water 40.0 C part Maltitol Liquid 1.0 Betaine 0.5 α-glucan oligosaccharide 0.1 Pullulan 0.5 Tuberose polysaccharide 0.01 Hydroxypropyl methylcellulose stearoxy ether 0.05 (Acrylates / Alkyl acrylate (C10-30)) Crosspolymer 0.05 Arginine 0.05 Phenoxyethanol 0.2 Methylparaben 0.15 Purified water (total amount is 100) ------------------------------------- (Preparation method) Part A and Part B were heated to 70°C, and Part A was added to Part B while stirring with a homomixer (7000 rpm). The mixture was then dispersed with a high-pressure emulsifier (Microfluidizer, manufactured by Mizuho Kogyo Co., Ltd.). After cooling, Part C, which had been mixed in advance, was added to make a homogeneous liquid.

[0076] Example 29: Lotion Component Amount (wt%) ------------------------------------- Part A Hydrogenated lecithin (PC content 50-75%) 1.0 Polyglyceryl-5 Myristate 1.0 Ceramide 5 0.3 Diglycerin 1.0 1,3-Butylene glycol 3.0 1,2-Pentanediol 3.0 Plandool-SUN (Nippon Fine Chemical) 0.05 Plandool-MAS (Nippon Fine Chemicals) 0.05 Plandool-ISS (Nippon Fine Chemical) 0.05 Part B Purified water 30.0 C part Betaine 0.5 Nicotinamide 5.0 Tranexamic acid (Nippon Fine Chemicals) 1.0 Phenoxyethanol 0.2 Purified water (total amount is 100) ------------------------------------- (Preparation method) Part A and Part B were heated to 70°C, and Part A was added to Part B while stirring with a homogenizer (7000 rpm). After cooling, Part C, which had been mixed in advance, was added to make a homogenous liquid.

[0077] Example 30 Lotion Component Amount (wt%) -------------------------------------- Part A Hydrogenated lecithin (PC content 76-99%) 0.8 Polyglyceryl-20 Myristate 1.0 Ceramide 6 0.2 Ceramide 3 0.2 Ceramide 2 0.1 1,3-Butylene glycol 2.0 1,2-Hexanediol 3.0 Part B Neosolue-Aqulio (Nippon Fine Chemicals) 1.0 Tranexamic acid (Nippon Fine Chemicals) 2.0 Arbutin (Nippon Fine Chemicals) 2.0 Phenoxyethanol 0.4 Purified water (total amount is 100) -------------------------------------- (Preparation method) Part A and Part B were mixed uniformly at about 70° C. Part A was added to Part B while stirring with a homomixer (7000 rpm), and the mixture was cooled.

[0078] Example 31 Lotion Component Amount (wt%) -------------------------------------- Part A Hydrogenated lecithin (PC content 50-75%) 0.8 Polyglyceryl-6 Caprate 0.5 Polyglyceryl-10 Caprate 0.5 Ceramide 6 0.1 Ceramide 3 0.1 Ceramide 2 0.1 Estradiol 0.002 Pantothenyl alcohol 0.1 1,3-Butylene glycol 2.0 1,2-Pentanediol 3.0 Part B Purified water (total amount is 100) C part Cyclic lysophosphatidic acid sodium 0.001 Neosolue-AquaS (Nippon Fine Chemical) 1.0 PEG / PPG / Polybutylene Glycol-8 / 5 / 3 Glycerin 0.5 Polyquaternium-51 0.5 Phenoxyethanol 0.2 Methylparaben 0.15 Purified water 20.0 -------------------------------------- (Preparation method) Part A and Part B were heated to 70°C, and while stirring with a propeller, Part A was added to Part B. After cooling, Part C, which had been mixed in advance, was added to make a homogeneous liquid.

[0079] Example 32 Lotion Component Amount (wt%) -------------------------------------- Part A Hydrogenated lecithin (PC content 76-99%) 0.8 Polyglyceryl-10 Stearate 0.6 Polyglyceryl-10 Myristate 0.4 Ceramide 5 0.3 Cetyl Tranexamate HCl 1.0 Glycerin 8.0 Dipropylene glycol 2.0 1,3-Propanediol 7.0 Part B Purified water 50.0 C part 3-O-Ethyl ascorbic acid (Nippon Fine Chemicals) 1.0 Arbutin (Nippon Fine Chemicals) 1.0 Ethanol 3.0 Methylgluceth-10 2.0 Glycyrrhizic acid 2K 0.05 Tremoist-TP (Nippon Fine Chemical) 0.01 Xanthan gum 0.05 Phenoxyethanol 0.2 Methylparaben 0.15 Citric acid 0.1 Sodium citrate 0.2 Purified water (total amount is 100) -------------------------------------- (Preparation method) Part A and Part B were heated to 80°C, and Part A was added to Part B while stirring with a homogenizer (7000 rpm). After cooling, Part C, which had been mixed in advance, was added to make a homogenous liquid.

[0080] Example 33 Lotion Component Amount (wt%) -------------------------------------- Part A Hydrogenated lecithin (PC content 50-75%) 3.0 Polyglyceryl-5 Myristate 1.0 Sucrose dimyristate 1.0 Ceramide 2 0.3 Glabridin 0.05 Eucalyptus oil 0.2 1,3-Butylene glycol 10.0 Part B Purified water 40.0 C part Tranexamic acid (Nippon Fine Chemicals) 2.0 Nicotinamide 5.0 Phytic acid 0.3 Tripropylene glycol 2.0 Sodium hyaluronate 0.01 Dipropylene glycol 2.0 Carbomer 0.01 Phenoxyethanol 0.4 Purified water (total amount is 100) -------------------------------------- (Preparation method) Part A and Part B were heated to 70°C, and while stirring with a homomixer (7000 rpm), Part A was added to Part B. After cooling, Part C, which had been mixed in advance, was added to make a homogeneous liquid.

[0081] Example 34 Transparent gel lotion Component Amount (wt%) ------------------------------------- Part A Hydrogenated lecithin (PC content 76-99%) 2.0 Polyglyceryl-10 Laurate 1.0 Ceramide 6 0.3 Tocopherol nicotinate 0.1 1,2-Pentanediol 3.0 1,3-Butylene glycol 3.0 Part B Sorbitol solution (70%) 5.0 Purified water 30.0 C part Glycerin 10.0 Glucose 1.0 Pullulan 0.2 Ethylhexylglycerin 0.2 Polymethacryloyl lysine 0.05 Crystalline cellulose powder 0.1 Locust bean gum 0.03 Hydroxyethyl cellulose 0.05 Xanthan gum 0.05 Sodium hyaluronate 0.01 Tranexamic acid (Nippon Fine Chemicals) 2.0 Carbomer 0.06 Purified water (total amount is 100) -------------------------------------- (Preparation method) Part A and Part B were weighed into a container, and Part A was added to Part B while stirring with a paddle at 70° C. After cooling, Part C, which had been mixed in advance, was added to make a homogeneous liquid.

[0082] Example 35 Transparent gel lotion Component Amount (wt%) ------------------------------------- Part A Hydrogenated lecithin (PC content 50-75%) 1.0 Sucrose palmitate 1.0 Ceramide 3 0.4 Catechin 0.02 Dipropylene glycol 5.0 1,2-Pentanediol 3.0 Part B Purified water 50.0 C part PPG-6-decyltetradeceth-30 0.2 PEG-30 Phytosterol 0.3 PEG-4M 0.2 Methylgluceth-10 1.0 Pyridoxine hydrochloride 0.05 Ethylhexylglycerin 0.2 Phenoxyethanol 0.4 Tranexamic acid (Nippon Fine Chemicals) 2.0 Tremoist-TP (Nippon Fine Chemical) 0.01 Hydrolyzed collagen 0.01 Purified water (total amount is 100) (Acrylate dimethyl taurate ammonium / vinylpyrrolidone) copolymer 0.05 (Acrylates / Alkyl acrylate (C10-30)) Crosspolymer 0.15 Arginine 0.25 -------------------------------------- (Preparation method) Part A and Part B were weighed into containers, and Part A was added to Part B while stirring with a paddle at 80° C. After cooling, Part C, which had been mixed in advance, was added to make a homogeneous liquid.

[0083] Example 36 Scalp lotion Component Amount (wt%) -------------------------------------- Part A Hydrogenated lecithin (PC content 76-99%) 2.0 Sucrose Laurate 1.0 Sucrose myristate 0.5 Ceramide 6 1.0 Dipropylene glycol 5.0 1,3-Butylene glycol 5.0 Part B Purified water 40.0 C part Maltitol Liquid 0.5 PEG-60 hydrogenated castor oil 0.3 Ethanol 10.0 Neosolue-AquaS (Nippon Fine Chemical) 2.0 Betaine 0.2 Hydroxypropyl chitosan liquid 0.05 Carrot extract 0.1 Pyridoxine hydrochloride 0.05 Panthenol 0.1 Dipotassium glycyrrhizinate 0.1 Phenoxyethanol 0.3 Purified water (total amount is 100) -------------------------------------- (Preparation method) Part A and Part B were weighed into containers, and Part A was added to Part B while stirring with a paddle at 80° C. After cooling, Part C, which had been mixed in advance, was added to make a homogeneous liquid.

[0084] Example 37 Scalp lotion Component Amount (wt%) ------------------------------------- Part A Hydrogenated lecithin (PC content 50-75%) 2.0 Polyglyceryl-10 Dioleate 2.0 Ceramide 1 1.0 Ellagic acid 0.05 1,2-Hexanediol 5.0 1,3-Butylene glycol 4.0 Part B Purified water 40.0 C part Neosolue-Aqulio (Nippon Fine Chemicals) 1.0 Tocopherol acetate 0.05 Menthol 0.1 Betaine 0.2 Swertia japonica extract 0.1 Tamasakizurafuji Root Extract 0.003 Hinokitiol 0.1 PCA-Na 0.1 Carbomer 0.01 Potassium hydroxide 0.01 Pentetic acid 5Na 0.05 Phenoxyethanol 0.4 Purified water (total amount is 100) ------------------------------------- (Preparation method) Part A and Part B were heated to 70°C, and while stirring with a homomixer (7000 rpm), Part A was added to Part B. After cooling, Part C, which had been mixed in advance, was added to make a homogeneous liquid.

[0085] Example 38 Hair growth agent Component Amount (wt%) ------------------------------------- Part A Hydrogenated lecithin (PC content 76-99%) 3.0 Polyglyceryl-10 Myristate 4.0 Ceramide 3 1.0 1,2-Pentanediol 5.0 Glycerin 2.0 Part B PEG-60 hydrogenated castor oil 0.3 Purified water 40.0 C part Betaine 0.5 Ethanol 20.0 Menthol 0.1 Neosolue-AquaS (Nippon Fine Chemical) 2.0 Orange oil 0.05 Panthenyl ethyl ether 0.2 Carrot Extract 1.0 Clara Extract 2.0 Chlorella Extract 1.0 Trehalose 0.5 Nicotinamide 1.0 Piroctone Olamine 0.1 Dipotassium glycyrrhizinate 0.1 Purified water (total amount is 100) ------------------------------------- (Preparation method) Part A and Part B were heated to 70°C, and Part A was added to Part B while stirring with a homogenizer (7000 rpm). After cooling, Part C, which had been mixed in advance, was added to make a homogenous liquid.

[0086] Example 39 Hair growth agent Component Amount (wt%) ------------------------------------- Part A Hydrogenated lecithin (PC content 50-75%) 1.0 Polyglyceryl-10 Palmitate 0.4 Ceramide 2 0.1 1,3-Butylene glycol 5.0 Part B Purified water 45.0 C part Neosolue-Aqulio (Nippon Fine Chemicals) 0.5 Dipropylene glycol 2.0 Lactic acid 0.1 Tremoist-TP (Nippon Fine Chemical) 0.01 Ethanol 10.0 Menthol 0.1 Menthyl glyceryl ether 0.15 Panthenyl ethyl ether 0.2 Camphor 0.1 Cordyceps sinensis extract 1.0 Swertia japonica extract 1.0 Loquat Leaf Extract 1.0 Hydrolyzed hyaluronic acid 0.02 Cyclic lysophosphatidic acid sodium 0.001 Capsicum extract 0.01 Betaine 0.3 Trehalose 0.2 Cymen-5-ol 0.1 Tocopherol acetate 0.05 β-Glycyrrhetinic acid 0.05 Purified water (total amount is 100) ------------------------------------- (Preparation method) Part A and Part B were heated to 70°C, and Part A was added to Part B while stirring with a homogenizer (7000 rpm). After cooling, Part C, which had been mixed in advance, was added to make a homogenous liquid.

[0087] Example 40 Emulsion Component Amount (wt%) -------------------------------------- Part A Plandool-DP (Nippon Fine Chemical) 1.0 Cetyl ethylhexanoate (Nippon Fine Chemicals) 5.0 Cetanol 1.2 Dimethicone 100cs 1.0 Myristyl Alcohol 2.0 Oleyl alcohol 1.0 Part B Stearoxy hydroxypropyl methylcellulose 0.1 Xanthan gum 0.1 Sodium citrate (appropriate amount) 3-O-Ethyl ascorbic acid (Nippon Fine Chemicals) 0.5 Tranexamic acid (Nippon Fine Chemicals) 2.0 Nicotinamide 5.0 Phenoxyethanol 0.2 Purified water 10.0 C part Phytocompo-PP (Nippon Fine Chemical) 1.0 Glycerin 5.0 D part Methylparaben 0.15 Phytic Acid 0.5 Purified water (total amount is 100) Part E Water-dispersed composition of Example 17 40.0 -------------------------------------- (Preparation method) Parts A and D were heated to about 70°C and uniformly dissolved. Part C was heated to about 70°C and uniformly dispersed. Part A was added to part C while stirring with a homodisper, and then part D was added. After cooling, parts B and E were added at about 40°C and stirred to mix uniformly.

[0088] Example 41 Emulsion Component Amount (wt%) ------------------------------------- Part A Glycerin 3.0 Diglycerin 1.0 1,3-Butylene glycol 5.0 Phytocompo-C (Nippon Fine Chemical) 1.5 Part B Triethylhexanoin 3.0 LUSPLAN SR-DM4 (Nippon Fine Chemicals) 0.5 Hydrogenated polyisobutene 3.5 Isododecane 1.5 Cetostearyl alcohol 1.0 Arachyl alcohol 0.1 Jojoba Alcohol 3.0 Chiral alcohol 0.3 Selachyl alcohol 0.1 Hexyldecanol 0.5 C part (Hydroxyethyl acrylate / Sodium acryloyldimethyltaurate) copolymer 0.2 Tremoist-TP (Nippon Fine Chemical) 0.03 Carbomer 0.1 Potassium hydroxide 0.2 Purified water 30.0 D part Neosolue-AquaS (Nippon Fine Chemical) 0.5 Polyquaternium-51 1.0 Tranexamic acid (Nippon Fine Chemicals) 2.0 Nicotinamide 5.0 Methylparaben 0.15 Purified water (total amount is 100) Part E Water-dispersed composition of Example 20 10.0 ------------------------------------- (Preparation method) Parts A, B, and D were mixed and heated to about 70°C to dissolve and disperse uniformly. Part C was mixed and stirred to make a viscous liquid. Part B was added to Part A while stirring with a homodisper, and then Part D was added to emulsify. After cooling, Parts C and E were added at about 40°C and stirred.

[0089] Example 42 Skin Care Cream Component Amount (wt%) ------------------------------------- Part A Sodium cyclic lysophosphatidic acid 0.01 Glycerin 9.0 Dipropylene glycol 5.0 Tripropylene glycol 2.0 Sucrose stearate 1.5 Glyceryl stearate 1.0 Part B (C13-15) Alkanes 8.0 Vaseline 10.0 Pentaerythrityl tetraisostearate 5.0 Astaxanthin 0.01 Cetyl PG hydroxyethyl palmitamide 0.05 Dipentaerythrityl hexahydroxystearate 1.0 C part Carbomer 0.1 Potassium hydroxide 0.07 Xanthan gum 0.1 Purified water 10.0 D part Phenoxyethanol 0.4 Ethylhexylglycerin 0.2 Methylparaben 0.05 Nicotinamide 5.0 Purified water (total amount is 100) Part E Water-dispersed composition of Example 6 10.0 ------------------------------------- (Preparation method) Parts A, B, and D were mixed and heated to about 70°C to dissolve and disperse uniformly. Part C was mixed and stirred to make a viscous liquid. Part B was added to Part A while stirring with a homodisper, and then Part D was added to emulsify. After cooling, Parts C and E were added at about 40°C and stirred.

[0090] Example 43 Skin Care Cream Component Amount (wt%) ------------------------------------- Part A Squalane 10.0 Stearic acid 1.0 Plandool-ISS (Nippon Fine Chemical) 1.0 Macadamia nut oil 3.0 Hydrogenated rapeseed oil alcohol 2.0 Olive oil fatty acid cetearyl 1.0 Sorbitan olivate 0.8 Polyglyceryl-10 Oleate 1.0 Part B Acrylic acid / alkyl methacrylate copolymer 0.1 Potassium hydroxide 0.07 (Ammonium acryloyldimethyltaurate / Beheneth-25) methacrylate crosspolymer 0.2 Tremoist-SL (Nippon Fine Chemicals) 1.0 Purified water 20.0 Hydrolyzed polygamma-glutamic acid K 0.1 Sodium polyglutamate 0.1 Oligopeptide-24 0.05 C part PrimeLipid PI (Nippon Fine Chemical) 1.0 PEG-8 5.0 PEG-2M 2.0 Glyceryl Caprylate 0.8 Purified water (total amount is 100) D part Water-dispersed composition of Example 18 15.0 ------------------------------------- (Preparation method) Parts A and C were mixed and heated to about 70°C to dissolve and disperse uniformly. Part B was mixed and stirred to make a viscous liquid. Part C was emulsified by adding part A while stirring with a homomixer. After cooling, parts B and D were added at about 40°C and stirred.

[0091] Example 44 Skin Care Cream Component Amount (wt%) ------------------------------------- Part A Plandool-MAS (Nippon Fine Chemicals) 2.0 Plandool-LG1 (Nippon Fine Chemicals) 1.0 Paraffin Wax 3.0 Shea Butter 3.0 Squalane 8.0 Cetanol 1.8 Hydrogenated Cocoglycerides 0.8 Glyceryl stearate 1.0 Behenyl Alcohol 1.5 Sorbitan stearate 1.0 Polyglyceryl-10 Laurate 1.0 PEG-60 Glyceryl Isostearate 1.0 Methyl glucose sesquistearate 1.5 Part B Xanthan gum 0.1 Hydroxyethyl cellulose 0.1 Crystalline cellulose powder 0.3 Stearoxy hydroxypropyl methylcellulose 0.1 Tranexamic acid (Nippon Fine Chemicals) 2.0 Purified water 20.0 C part Glycerin 8.0 Dipropylene glycol 5.0 Sorbitol 2.0 Neosolue-Aqulio (Nippon Fine Chemicals) 1.0 Methylparaben 0.15 Purified water (total amount is 100) D part Water-dispersed composition of Example 9 10.0 ------------------------------------- (Preparation method) Parts A and C were mixed and heated to about 70°C to dissolve and disperse uniformly. Part B was mixed and stirred to make a viscous liquid. Part C was emulsified by adding part A while stirring with a homomixer. After cooling, parts B and D were added at about 40°C and stirred.

[0092] Example 45 Skin Care Cream Component Amount (wt%) ------------------------------------- Part A Glycerin 12.0 1,3-Butylene glycol 3.0 Phytocompo-PP (Nippon Fine Chemical) 2.5 Part B Olive Fruit Oil 3.0 Olive oil 1.5 Shea butter 1.0 Pentaerythrityl tetraethylhexanoate (Nippon Fine Chemicals) 3.0 Sucrose stearate 0.8 Cetearyl Glucoside 1.2 Behenyl Alcohol 1.5 Ascorbyl Tetrahexyldecanoate 7.0 Isopropyl Lauroyl Sarcosine 2.0 Hydrogenated Cocoglycerides 3.0 Cetanol 2.5 Sorbitan stearate 0.8 C part Xanthan gum 0.05 Tremoist-SL (Nippon Fine Chemicals) 1.0 Tuberose polysaccharide 0.01 Water-soluble collagen 0.05 Hydrolyzed Collagen 0.5 Sodium pyrosulfite 0.03 Arbutin (Nippon Fine Chemicals) 1.0 Tranexamic acid (Nippon Fine Chemicals) 1.0 Purified water 10.0 D part Neosolue-Aqulio (Nippon Fine Chemicals) 1.0 Propanediol 3.0 Methylparaben 0.1 Glyceryl Caprylate 1.0 Purified water (total amount is 100) Part E Water-dispersed composition of Example 11 15.0 ------------------------------------- (Preparation method) Parts A, B, and D were mixed and heated to about 70°C to dissolve and disperse uniformly. Part C was mixed and stirred to make a viscous liquid. Part B was added to Part A while stirring with a homodisper, and then Part D was added to emulsify. After cooling, Parts C and E were added at about 50°C and stirred.

[0093] Example 46 Skin Care Cream Component Amount (wt%) ------------------------------------ Part A Neosolue-DiSM (Nippon Fine Chemicals) 5.0 Jojoba Oil 2.0 Plandool-H (Nippon Fine Chemical) 1.0 Caprylic / capric triglyceride (Nippon Fine Chemicals) 3.0 LUSPLAN DD-DHR (Nippon Fine Chemicals) 1.0 Plandool-SUN (Nippon Fine Chemical) 1.3 Propylene glycol stearate 0.6 Squalane 3.0 Behenyl Alcohol 2.0 Liquid Isoparaffin 0.5 Carnauba wax 0.3 Corn oil 0.3 Rapeseed oil 1.0 Sunflower oil 1.0 wheat germ oil 1.0 Linseed oil 0.1 Cottonseed oil 0.1 Soybean oil 0.1 Shea butter 0.5 Stigmasterol 1.0 Stigmastanol 1.0 Dihydrocholesterol 0.1 Lanosterol 0.1 Dihydrolanosterol 0.1 Cholesteryl nonanoate 0.1 Cholesteryl stearate 0.1 Cholesteryl Isostearate 1.0 Cholesteryl Oleate 0.1 Cholesteryl 12-hydroxystearate 0.1 Long-chain branched fatty acid cholesteryl 0.3 Octyldodecyl myristate 1.0 Octyldodecyl isostearate 1.0 Dimer dilinoleic acid hydrogenated castor oil 1.0 Hydroxyalkyl dimer dilinoleyl ether 1.0 Dipentaerythrityl tetra(hydroxystearate / isostearate) 0.5 Rice bran oil fatty acid phytosteryl 0.5 Phenyl Trimethicone 1.0 Diphenyl Dimethicone 1.0 Methylhydrogenpolysiloxane 1.0 Polyglyceryl-3 Polydimethylsiloxyethyl Dimethicone 0.5 Dimethicone 50cs 0.3 Polyoxyethylene-methylpolysiloxane copolymer 1.0 Tocopherol Ferulate 0.1 Tocopherol phosphate 0.1 Tocotrienol 0.1 Tannins 0.01 Sesamin 0.01 Proanthocyanidin 0.01 Glabridin 0.01 Glabren 0.01 Liquiritin 0.01 Isoliquiritin 0.01 Lactoferrin 0.01 Gingerol 0.01 Gingerol 0.01 Part B (Acryloyldimethyltaurine / Beheneth-25 methacrylate) copolymer 0.2 Crystalline cellulose 0.1 Gellan gum 0.1 Carboxyvinyl polymer 0.1 Potassium hydroxide 0.08 Purified water 20.0 C part Phytocompo-PP (Nippon Fine Chemical) 1.0 Polyglyceryl-10 Stearate 0.5 Glycerin 7.0 Dipropylene glycol 7.0 D part Citric acid 0.07 Sodium citrate (appropriate amount) EDTA-2Na 0.05 Pentetic acid 5Na 0.03 Phenoxyethanol 0.4 Purified water (total amount is 100) Part E Water-dispersed composition of Example 12 5.0 -------------------------------------- (Preparation method) Part A was mixed and heated to about 70°C and dissolved uniformly. Part B was mixed and stirred to form a viscous liquid. Part C was mixed and heated to about 70°C and dispersed uniformly. Part D was mixed and heated to about 70°C and dissolved uniformly. Part A was added to part C while stirring with a homogenizer, and then part D was added and emulsified. After cooling, parts B and E were added at about 50°C and stirred.

[0094] Example 47 Skin Care Cream Component Amount (wt%) -------------------------------------- Part A Plandool-G (Nippon Fine Chemical) 1.0 Neosolue-Aqulio (Nippon Fine Chemicals) 1.5 Diethylhexyl sebacate (Nippon Fine Chemicals) 8.0 Diisopropyl sebacate (Nippon Fine Chemicals) 2.0 Theobroma grandiflorum seed oil 3.0 Isostearate batyl 2.0 Shea Butter 3.0 (Dimethicone / vinyl dimethicone) crosspolymer 0.3 (Vinyl dimethicone / lauryl dimethicone) crosspolymer 0.5 (Dimethicone / PEG-10 / 15) Crosspolymer 0.5 (PEG-15 / Lauryl Dimethicone) Crosspolymer 0.2 (Alkyl acrylate / dimethicone) copolymer 0.1 Isostearyl pivalate 0.1 Pentaerythrityl tetraethylhexanoate (Nippon Fine Chemicals) 0.1 Stearyl alcohol 3.5 Cetanol 1.3 Sucrose Coconut Fatty Acid 1.0 Polyglyceryl-3 Distearate 0.8 Triglyceride (C10-18) 3.0 Squalane 3.0 Dimethicone 100cs 1.0 Tocopherol 0.1 Ascorbyl Tetrahexyldecanoate 8.0 Tocopheryl Ascorbyl Phosphate 2.0 Placenta extract 1.0 Oryzanol 0.3 Phytosphingosine 0.0001 Ubiquinone 0.03 Carotene 0.05 Lycopene 0.01 Astaxanthin 0.01 Lutein 0.01 Fullerene 0.001 Peanut oil 0.1 Rice bran oil 1.0 Hydrogenated castor oil 0.3 Jojoba Oil 2.0 Orange Roughy Oil 1.0 Liquid lanolin (Nippon Seika) 1.0 Lanolin (Nippon Fine Chemicals) 1.0 Polyoxyethylene Lanolin 1.0 Lanolin alcohol (Nippon Fine Chemicals) 0.3 Lanolin Alcohol Acetate 0.1 Cholesteryl acetate 0.1 Octocrylene 0.5 Sorbitan sesquistearate 1.2 Part B Tremoist-TP (Nippon Fine Chemical) 0.05 Water-soluble collagen 0.05 Hydrolyzed Collagen 0.5 Glutathione 0.3 Arbutin (Nippon Fine Chemicals) 3.0 Nicotinamide 5.0 C part Propanediol 10.0 PPG-9 Diglyceryl 2.0 Diglycerin 1.0 Sodium pyrosulfite 0.1 Imidazolinium urea 0.1 Polyvinylpyrrolidone 0.1 Pullulan 0.1 Polyvinyl alcohol 0.1 Dehydroacetic acid 0.1 PEG-32 1.0 Polyglycerin-10 1.0 Pentetic acid 5Na 0.05 Phenoxyethanol 0.4 1,2-Pentanediol 2.0 Succinic acid 0.05 Sodium succinate (appropriate amount) Purified water (total amount is 100) D part Water-dispersed composition of Example 7 5.0 -------------------------------------- (Preparation method) Part A was heated to about 70°C and dissolved uniformly. Part B was homogenized using some purified water. Part C was heated to about 70°C and dispersed. Part A was gradually added to part C while stirring with a homomixer at about 70°C to emulsify, and after cooling to about 40°C, parts B and D were added and mixed uniformly. The pH was adjusted to 6.5-7.0 with sodium succinate.

[0095] Example 48 Emulsion Component Amount (wt%) ---------------------------------- Part A Phytocompo-SP (Nippon Fine Chemical) 10.0 Lysolecithin (Nippon Fine Chemicals) 0.1 Part B Squalane 4.0 Caprylic / capric triglyceride (Nippon Fine Chemicals) 4.0 α-Olefin Oligomer 2.5 Dimethicone 5cs 3.5 Cetanol 1.5 Glyceryl stearate 1.0 C part Hydroxyproline 0.05 Citric acid 0.01 Sodium citrate 0.09 Arbutin (Nippon Fine Chemicals) 3.0 Phenoxyethanol 0.3 Methylparaben 0.1 Acrylic acid / alkyl methacrylate copolymer 0.1 Potassium hydroxide 0.1 Purified water (total amount is 100) D part Water-dispersed composition of Example 22 40.0 ----------------------------------- (Preparation method) Parts A, B, and C were each taken, heated to about 70°C, and mixed uniformly. Part B was gradually added to part A while stirring with a homodisper, and then part C was added and emulsified. It was then cooled to about 40°C, and part D was added.

[0096] Example 49: Leave-in hair treatment Component Amount (wt%) ------------------------------------- Part A Polyquaternium-37 2.0 Squalane 2.0 PPG-3 Caprylyl Ether 2.0 Microcrystalline wax 0.1 Lanolin alcohol 0.2 Montan wax 0.1 Polyethylene wax 0.1 Rowlet 0.2 Ceresin 0.1 PG Dicaprylate 1.0 Almond oil 0.5 Ethylhexyl ethylhexanoate 1.0 Candelilla Wax Extract 0.1 Octyldodecyl erucate 4.5 Tocopherol acetate 0.02 Erucalactone MCT (Nippon Fine Chemicals) 2.0 Dipentaerythrityl trihydroxystearate 1.5 PPG-5 Phytosteryl 0.5 Glycerin 4.0 Sorbitol 2.0 Phenoxyethanol 0.5 Part B Hydrolyzed Hyaluronic Acid 0.1 Panthenol 0.1 Hydroxypropyltrimonium Hyaluronate 0.01 Polyquaternium-11 0.2 Glycosyl trehalose 0.1 Glyceryl glucoside 0.3 Arginine 0.1 C part Purified water (total amount is 100) Hydroxypropyl starch phosphate 1.0 D part Water-dispersed composition of Example 18 5.0 -------------------------------------- (Preparation method) Part C was uniformly dispersed and heated to about 80°C. Next, part A was heated to about 80°C and dissolved. Part A was added while stirring part C, mixed uniformly, and then cooled to about 40°C. Next, parts B and D were added and mixed uniformly.

[0097] Example 50 Leave-in scalp / hair treatment Component Amount (wt%) -------------------------------------- Part A Neosolue-Aqulio (Nippon Fine Chemicals) 1.0 Ethanol 40.0 Glycyrrhetinic acid 0.02 Erucalactone DES (Nippon Fine Chemicals) 1.5 PEG / PPG-20 / 20 Dimethicone 0.2 PEG-12 Dimethicone 0.4 Hydrogenated Retinol 0.1 Pyridoxine tris(hexyldecanoate) 0.05 Bisglyceryl ascorbate 0.3 Hexyl 3-glyceryl ascorbate 0.3 Part B Triethanolamine 0.1 Purified water (total amount is 100) (Acrylates / Alkyl acrylate (C10-30)) Crosspolymer 0.4 Carbomer 0.05 Tremoist-SL (Nippon Fine Chemicals) 1.0 (Acryloyldimethyltaurate ammonium / VP) copolymer 0.05 (Ammonium acryloyldimethyltaurate / Beheneth-25) methacrylate crosspolymer 0.1 Hydroxypropyl chitosan 0.1 Methylparaben 0.1 Phenoxyethanol 0.2 C part 3-O-Ethyl ascorbic acid (Nippon Fine Chemicals) 0.3 Nicotinamide 0.3 Pyridoxine hydrochloride 0.1 Caffeine 0.1 Glucosyl trehalose 0.1 Purified water 10.0 D part Hydrogenated lecithin (PC content 50-75%) 1.0 Polyglyceryl-10 Dimyristate 1.4 Ceramide 6 1.0 Stearyl glycyrrhetinate 0.05 1,2-Pentanediol 3.0 1,3-Butylene glycol 4.0 Part E Purified water 20.0 -------------------------------------- (Preparation method) Part A was heated to about 50°C and dissolved. Next, part B was uniformly dispersed to form a viscous liquid. Parts D and E were heated to 70°C, and part D was added to part E while stirring with a homomixer (4000 rpm), and cooled (part F). Part A was added to part B while stirring, and mixed uniformly. Next, part C was added, and mixed uniformly. After cooling, part F was added, and mixed uniformly.

[0098] Example 51 Leave-on Hair Treatment Component Amount (wt%) ---------------------------------- Part A Neosolue-Aqulio (Nippon Fine Chemicals) 2.0 Cetanol 3.8 Caprylyl glucoside (50%) 1.5 Glycerin 4.0 Phenoxyethanol 0.5 Part B Ethanol 5.0 C part Polyquaternium-6 0.6 Polyquaternium-7 0.4 Polyquaternium-39 0.5 Purified water (total amount is 100) D part Water-dispersed composition of Example 23 10.0 ---------------------------------- (Preparation method) Part C was heated to about 80°C and dissolved. Next, part A was heated to about 80°C and dissolved. Part A was added to part C while stirring, and after uniform mixing, it was cooled to about 40°C. Next, parts B and D were added and mixed uniformly.

[0099] Example 52 Liquid Foundation Component Amount (wt%) --------------------------------- Part A PrimeLipid PI (Nippon Fine Chemical) 1.0 Octyltriazone 1.5 Ethylhexyl methoxycinnamate 1.0 Quaternium-18 Hectorite 0.5 Part B Cyclomethicone 25.0 Polyether modified silicone mixture 5.0 (BY22-008M manufactured by Toray Dow Corning Silicone Co., Ltd.) Polyglyceryl-2 Isostearate 1.0 Titanium oxide-iron oxide mixture 12.5 Mica 6.0 C part Glycerin 5.0 Neosolue-AquaS (Nippon Fine Chemical) 0.4 Methylparaben 0.2 Tranexamic acid (Nippon Fine Chemicals) 2.0 Purified water (total amount is 100) D part Water-dispersed composition of Example 10 5.0 --------------------------------- (Preparation method) Part A was heated to about 80°C and thoroughly dispersed. Part B heated to about 80°C was added thereto, and then part C heated to about 80°C was added and emulsified using a homogenizer. After cooling to room temperature, part D was added and stirred.

[0100] Example 53 Foundation Component Amount (wt%) ------------------------------------ Part A Isododecane 10.0 Caprylic / capric triglyceride (Nippon Fine Chemicals) 4.0 Ethylhexyl methoxycinnamate 3.0 Plandool-SUN (Nippon Fine Chemical) 1.0 Plandool-LG2 (Nippon Fine Chemicals) 1.0 Plandool-LG4 (Nippon Fine Chemicals) 1.0 Vaseline 1.0 Isotridecyl isononanoate 2.0 Ascorbyl Tetrahexyldecanoate 0.1 Dextrin palmitate 0.3 Sorbitan isostearate 1.5 Tribehenin 0.5 (Butyl acrylate / glycol dimethacrylate) crosspolymer, silica, (Methyl methacrylate / glycol dimethacrylate) crosspolymer mixture 2.0 Boron nitride 1.0 Polysorbate 20 2.0 PEG-60 hydrogenated castor oil 1.0 Disteardimonium hectorite (20%) 2.5 Polypropylsilsesquioxane, Cyclopentasiloxane mixture 1.0 Mica 15.0 Talc 4.0 Zinc oxide 5.0 Titanium dioxide 10.0 Iron oxide 1.5 Part B Water - Amount that totals 100 Dipropylene glycol 4.0 Maltitol (75% liquid) 1.0 Neosolue-AquaS (Nippon Fine Chemical) 0.4 Sodium chloride 1.0 1,3-Butylene glycol 1.0 Tremoist-SL (Nippon Fine Chemicals) 1.0 Ethanol 0.5 Phenoxyethanol 0.3 C part Water-dispersed composition of Example 19 4.0 ------------------------------------ (Preparation method) Part A was heated to about 70°C and thoroughly stirred to disperse uniformly. Part B was heated to about 70°C and homogenized, then part B was added to part A, stirred at about 70°C to emulsify, and cooled to about 40°C. Part C was added and stirred.

[0101] Example 54 Sunscreen cosmetic Component Amount (wt%) ----------------------------------- Part A FINEX-33W (Sakai Chemical Industry) 5.0 STR-100W (Sakai Chemical Industry) 5.0 Purified water (total amount is 100) 1,3-Butylene glycol 7.0 Disodium edetate 0.05 Triethanolamine 1.0 Part B Oxybenzone 3.0 Octyl paramethoxycinnamate 5.0 t-Butyl methoxybenzoylmethane 3.0 Diethylhexyl sebacate (Nippon Fine Chemicals) 8.0 Plandool-H (Nippon Fine Chemical) 2.0 Plandool-SUN (Nippon Fine Chemical) 2.0 Plandool-MAS (Nippon Fine Chemicals) 0.1 Plandool-LG1 (Nippon Fine Chemicals) 0.1 Plandool-LG2 (Nippon Fine Chemicals) 0.1 Plandool-LG3 (Nippon Fine Chemicals) 0.1 Plandool-LG4 (Nippon Fine Chemicals) 0.1 LUSPLAN PI-DA (Nippon Fine Chemical) 3.0 Cetyl ethylhexanoate 3.0 Diisopropyl sebacate (Nippon Fine Chemicals) 5.0 Dimethicone 2cs 5.0 Sucrose stearate 1.5 Polyglyceryl-10 Stearate 2.0 Stearyl alcohol 3.0 Batyl alcohol 1.0 Stearic Acid 3.0 Glyceryl Monostearate 3.0 Polyethyl acrylate 1.0 Phenoxyethanol 0.5 C part Water-dispersed composition of Example 14 10.0 ----------------------------------- (Preparation method) Part A was heated to about 80°C and thoroughly dispersed. Part B, which had been heated to about 80°C, was added thereto, and emulsified using a homogenizer. After cooling to room temperature, part C was added and stirred.

[0102] Example 55 Sunscreen Cosmetic Component Amount (wt%) ----------------------------------- Part A 1,3-Butylene glycol 10.0 Glycerin 9.0 Phytocompo-PP (Nippon Fine Chemical) 1.0 Octocrylene 4.0 Octyl Salicylate 4.0 Diethylamino hydroxybenzoyl hexyl benzoate 2.25 t-Butyl methoxydibenzoylmethane 1.0 Diethylhexyl sebacate (Nippon Fine Chemicals) 3.0 Pentaerythrityl tetraethylhexanoate (Nippon Fine Chemicals) 2.0 Dimethicone 1.5 Diisopropyl sebacate (Nippon Fine Chemicals) 1.0 Behenyl Alcohol 2.0 Cetearyl Alcohol 2.0 Plandool-MAS (Nippon Fine Chemicals) 1.0 Tocopherol 0.05 Part B Neosolue-AquaS (Nippon Fine Chemical) 1.0 Methylparaben (appropriate amount) Water - Amount that totals 100 C part Carbomer (2%) 5.0 Tremoist-SL (Nippon Fine Chemicals) 10.0 DIS-AB-10W (Sakai Chemical Industry) 5.0 D part Water-dispersed composition of Example 21 30.0 ----------------------------------- (Preparation method) Parts A and B were dissolved by heating to about 70℃. Part B was gradually added to part A while stirring to emulsify. After cooling, parts C and D were mixed at 45℃.

[0103] Example 56: Serum Component Amount (mass%) ------------------------------------- Part A Glycerin 1.0 1,3-Butylene glycol 4.0 Phytocompo-SP (Nippon Fine Chemical) 5.0 Propylene glycol 3.0 Part B Diethylhexyl succinate (Nippon Fine Chemicals) 4.0 LUSPLAN PI-DA (Nippon Fine Chemical) 0.1 C part Purified water (total amount is 100) Methylparaben 0.1 Inulin-SC (Nippon Fine Chemical) 1.0 D part Carbomer (2%) neutralized with KOH 5.0 Tremoist-SL (Nippon Fine Chemicals) 2.5 Ethanol 5.0 Phenoxyethanol 0.2 Part E Water-dispersed composition of Example 19 20.0 ------------------------------------- (Preparation method) Part B, which had been uniformly dissolved at 80°C, was mixed with the uniformly dispersed Part A while stirring. Then, Part C, which had been heated to 80°C, was mixed with stirring. After cooling, Parts D and E were added while stirring.

[0104] Example 57 Serum Component Amount (mass%) ------------------------------------- Part A Glycerin 1.0 1,3-Butylene glycol 4.0 Phytocompo-SP (Nippon Fine Chemical) 5.0 Propylene glycol 3.0 Part B Dimethicone (10cs) 2.0 C part Purified water (total amount is 100) Inulin-SC (Nippon Fine Chemical) 5.0 D part Carbomer (2%) neutralized with KOH 5.0 Tremoist-SL (Nippon Fine Chemicals) 2.5 Ethanol 5.0 Phenoxyethanol 0.2 Part E Water-dispersed composition of Example 10 20.0 ------------------------------------- (Preparation method) Part B, which had been uniformly dissolved at 80°C, was mixed with the uniformly dispersed Part A while stirring. Then, Part C, which had been heated to 80°C, was mixed with stirring. After cooling, Parts D and E were added while stirring.

[0105] Example 58 Skin Care Cream Component Amount (mass%) ------------------------------------- Part A Phytocompo-SP (Nippon Fine Chemical) 5.0 Glycerin 10.0 1,3-Butylene glycol 1.0 1,2-Pentanediol 2.0 Part B Squalane 7.0 Plandool-MAS (Nippon Fine Chemicals) 5.0 Behenyl Alcohol 3.0 Pentaerythrityl tetraethylhexanoate (Nippon Fine Chemicals) 2.0 Cetearyl Alcohol 1.5 Cetyl palmitate 1.5 Dimethicone (10cs) 0.5 Stearic acid 1.0 Tocopherol 0.1 C part Purified water (total amount is 100) Inulin-SC (Nippon Fine Chemical) 1.0 Xanthan gum (2% aqueous solution) 3.0 Phenoxyethanol 0.5 D part Carbomer (2%) neutralized with KOH 7.0 Part E Water-dispersed composition of Example 20 20.0 ------------------------------------- (Preparation method) Part A was uniformly dispersed while being heated to 70°C, and then part B was dissolved uniformly at 70°C and mixed with it while being stirred. Then, part C was heated to 70°C and mixed with it while being stirred. After cooling, parts D and E were added with stirring.

[0106] Example 59 Lotion Component Amount (mass%) ------------------------------------- Part A Purified water (total amount is 100) Ethanol 9.0 BisPEG-18 methyl ether dimethyl silane 5.0 Inulin-SC (Nippon Fine Chemical) 1.0 1,2-Pentanediol 1.0 Phenoxyethanol (appropriate amount) Citric acid (appropriate amount) Sodium citrate (appropriate amount) Neosolue-AquaS (Nippon Fine Chemical) 1.0 Part B Acrylates Copolymer 0.5 Dipropylene glycol 1.0 Purified water 5.0 Water-dispersed composition of Example 15 10.0 ------------------------------------- (Preparation method) Part A and Part B were each dissolved uniformly. Part B was added to Part A and mixed until uniform.

[0107] Example 60 Lotion Component Amount (mass%) ------------------------------------- Part A PEG-40 hydrogenated castor oil 0.30 Neosolue-DiSM (Nippon Fine Chemicals) 0.20 1,3-Butylene glycol 3.0 Glycerin 2.0 Part B Purified water (total amount is 100) Inulin-SC (Nippon Fine Chemical) 1.0 Phenoxyethanol (appropriate amount) C part Tremoist-SL (Nippon Fine Chemicals) 1.0 Carboxymethyl dextran sodium 0.02 (Acrylate dimethyl taurate ammonium / vinyl pyrrolidone copolymer) 0.05 D part Water-dispersed composition of Example 20 10.0 ------------------------------------- (Preparation method) Parts A and B were dissolved uniformly at about 80°C. Part B was gradually added to part A and stirred. After cooling, parts C and D were added and mixed until uniform.

[0108] Example 61 Lotion Component Amount (wt%) -------------------------------------- Part A Hydrogenated lecithin (PC content 50-75%) 1.0 Polyglyceryl-10 Palmitate 0.5 Ubiquinone 0.2 Tocopherol 0.02 1,3-butylene glycol 10.0 Part B Purified water (total amount is 100) C part Neosolue-Aqulio (Nippon Fine Chemicals) 1.0 Tremoist-TP (Nippon Fine Chemical) 0.1 EDTA-2Na 0.05 Phenoxyethanol 0.4 -------------------------------------- (Preparation method) Part A and Part B were heated to about 80°C and mixed with stirring. After cooling, Part C was added to make a homogeneous liquid.

[0109] Example 62 Lotion Component Amount (wt%) -------------------------------------- Part A Hydrogenated lecithin (PC content 76-99%) 1.0 Polyglyceryl-10 Laurate 0.5 PrimeLipid ALPA (Nippon Fine Chemical) 0.1 Oryzanol 0.3 1,3-Butylene glycol 5.0 Part B Purified water (total amount is 100) C part Neosolue-Aqulio (Nippon Fine Chemicals) 1.0 Tremoist-TP (Nippon Fine Chemical) 0.1 EDTA-2Na 0.05 Phenoxyethanol 0.4 -------------------------------------- (Preparation method) Part A and Part B were heated to about 80°C and mixed with stirring. After cooling, Part C was added to make a homogeneous liquid.

[0110] Example 63 Lotion Component Amount (wt%) -------------------------------------- Part A Hydrogenated lecithin (PC content 76-99%) 1.0 Polyglyceryl-10 Stearate 1.0 Lutein 0.5 1,3-Butylene glycol 5.0 Part B Purified water (total amount is 100) C part Neosolue-Aqulio (Nippon Fine Chemicals) 1.0 Tremoist-TP (Nippon Fine Chemical) 0.1 EDTA-2Na 0.05 Phenoxyethanol 0.4 -------------------------------------- (Preparation method) Part A and Part B were heated to about 80°C and mixed with stirring. After cooling, Part C was added to make a homogeneous liquid.

[0111] Example 64 Lotion Component Amount (wt%) -------------------------------------- Part A Hydrogenated lecithin (PC content 50-75%) 1.0 Sucrose myristate 1.0 Astaxanthin 0.2 1,3-Butylene glycol 5.0 1,2-Pentanediol 3.0 Part B Purified water (total amount is 100) C part Neosolue-Aqulio (Nippon Fine Chemicals) 1.0 Tremoist-TP (Nippon Fine Chemical) 0.1 EDTA-2Na 0.05 Phenoxyethanol 0.4 -------------------------------------- (Preparation method) Part A and Part B were heated to about 80°C and mixed with stirring. After cooling, Part C was added to make a homogeneous liquid.

[0112] Example 65 Lotion Component Amount (wt%) -------------------------------------- Part A Hydrogenated lecithin (PC content 50-75%) 1.0 Sucrose dilaurate 1.0 Thioctic acid 0.5 Glycyrrhetinic acid 0.02 1,3-Butylene glycol 5.0 1,2-Pentanediol 3.0 Part B Purified water (total amount is 100) C part Neosolue-Aqulio (Nippon Fine Chemicals) 1.0 Tremoist-TP (Nippon Fine Chemical) 0.1 EDTA-2Na 0.05 Phenoxyethanol 0.4 -------------------------------------- (Preparation method) Part A and Part B were heated to about 80°C and mixed with stirring. After cooling, Part C was added to make a homogeneous liquid.

[0113] Example 66 Lotion Component Amount (wt%) -------------------------------------- Part A Hydrogenated lecithin (PC content 76-99%) 1.5 Sucrose dipalmitate 1.0 Ferulic acid 0.5 1,3-Butylene glycol 5.0 1,2-Pentanediol 3.0 Part B Purified water (total amount is 100) C part Neosolue-Aqulio (Nippon Fine Chemicals) 1.0 Tremoist-TP (Nippon Fine Chemical) 0.1 EDTA-2Na 0.05 Phenoxyethanol 0.4 -------------------------------------- (Preparation method) Part A and Part B were heated to about 80°C and mixed with stirring. After cooling, Part C was added to make a homogeneous liquid.

[0114] Example 67 Skin Care Cream Component Amount (mass%) ------------------------------------- Part A Phytocompo-SP (Nippon Fine Chemical) 5.0 Glycerin 10.0 1,3-Butylene glycol 1.0 1,2-Pentanediol 2.0 Part B Squalane 7.0 Plandool-MAS (Nippon Fine Chemicals) 5.0 Behenyl Alcohol 3.0 Pentaerythrityl tetraethylhexanoate (Nippon Fine Chemicals) 2.0 Cetearyl Alcohol 1.5 Cetyl palmitate 1.5 Dimethicone (10cs) 0.5 Stearic acid 1.0 Tocopherol 0.1 C part Purified water (total amount is 100) Phenoxyethanol 0.5 D part Carbomer (2%) neutralized with KOH 7.0 Part E Hydrogenated lecithin (PC content 76-99%) 1.0 Polyglyceryl-10 Laurate 1.0 Ceramide 4 0.5 Curcumin 0.1 Cyanocobalamin 0.001 1,3-Butylene glycol 10.0 F part Purified water 20.0 ------------------------------------- (Preparation method) Parts E and F were heated to 70°C, and part E was added to part F while stirring with a homomixer (4000 rpm), and cooled (part G). Part A was heated to 70°C and uniformly dispersed, and part B was mixed with stirring. Part C was then heated to 70°C and mixed with stirring. After cooling, parts D and G were added with stirring.

[0115] Example 68 Skin Care Cream Component Amount (mass%) ------------------------------------- Part A Phytocompo-SP (Nippon Fine Chemical) 5.0 Glycerin 10.0 1,3-Butylene glycol 1.0 1,2-Pentanediol 2.0 Part B Squalane 7.0 Plandool-MAS (Nippon Fine Chemicals) 5.0 Behenyl Alcohol 3.0 Pentaerythrityl tetraethylhexanoate (Nippon Fine Chemicals) 2.0 Cetearyl Alcohol 1.5 Cetyl palmitate 1.5 Dimethicone (10cs) 0.5 Stearic acid 1.0 C part Purified water (total amount is 100) Phenoxyethanol 0.5 D part Carbomer (2%) neutralized with KOH 7.0 Part E Hydrogenated lecithin (PC content 50-75%) 1.0 Sucrose Coconut Fatty Acid 1.0 Ceramide 6 0.5 Proanthocyanidin 0.1 1,3-Butylene glycol 5.0 1,2-Pentanediol 3.0 F part Purified water 20.0 ------------------------------------- (Preparation method) Parts E and F were heated to 70°C, and part E was added to part F while stirring with a homomixer (4000 rpm), and cooled (part G). Part A was heated to 70°C and uniformly dispersed, and part B was mixed with stirring. Part C was then heated to 70°C and mixed with stirring. After cooling, parts D and G were added with stirring.

[0116] Example 69: Serum Component Amount (mass%) ------------------------------------- Part A 1,3-Butylene glycol 10.0 Phytopresome (Nippon Fine Chemicals) 0.2 Part B Purified water (total amount is 100) C part Water-dispersed composition of Example 20 10.0 Phenoxyethanol 0.5 ------------------------------------- (Preparation method) Heat part A at 80°C and stir evenly. Add part A to part B heated to 80°C while stirring. After cooling, add part C.

[0117] Example 70: Serum Component Amount (mass%) ------------------------------------- Part A 1,3-Butylene glycol 10.0 Phytopresome Cera-236 (Nippon Fine Chemicals) 0.2 Part B Purified water (total amount is 100) C part Water-dispersed composition of Example 22 10.0 Phenoxyethanol 0.5 ------------------------------------- (Preparation method) Heat part A at 80°C and stir evenly. Add part A to part B heated to 80°C while stirring. After cooling, add part C.

[0118] Example 71 Serum Component Amount (mass%) ------------------------------------- Part A 1,3-Butylene glycol 5.0 Phytopresome MEL (Nippon Fine Chemicals) 2.0 Part B Purified water (total amount is 100) C part Water-dispersed composition of Example 20 10.0 Phenoxyethanol 0.5 ------------------------------------- (Preparation method) Heat part A at 80°C and stir evenly. Add part A to part B heated to 80°C while stirring. After cooling, add part C.

[0119] In the above formulation, details of the ingredients listed by product name are as follows: 〇Inulin-SC: Inulin LUSPLAN PI-DA: Dimer dilinoleate di(isostearyl / phytosteryl) LUSPLAN DD-DHR: Dimer dilinoleyl hydrogenated rosin condensate LUSPLAN SR-DM4: Dimer dilinoleyl dimer dilinoleate, tri(caprylic / capric acid)glyceryl Neosolue-Aqulio: bisethoxydiglycol cyclohexanedicarboxylate Neosolue-AquaS: Polyglyceryl-10 (eicosane diacid / tetradecanedioic acid), glycerin Neosolue-DiSM: Diisostearyl malate Phytocompo-PP: Hydrogenated lecithin, phytosterol Phytocompo-C: Hydrogenated lecithin, phytosterol, ceramide 2, ceramide 3, ceramide 6II Phytocompo-SP: Hydrogenated lecithin, phytosterol, 1,3-butylene glycol, glycerin Phytopresome: Hydrogenated lecithin, phytosterol Phytopresome Cera-236: Hydrogenated lecithin, phytosterol, ceramide 2, ceramide 3, ceramide 6 Phytopresome MEL: Hydrogenated lecithin, glycolipids, 1,3-butylene glycol, glycerin PrimeLipid ALPA: Lysophosphatidic acid, lysolecithin, glycerin, water, aluminum hydroxide PrimeLipid PI: Hydrogenated lecithin, phytosterol, lecithin, tocopherol Plandool-H: Dimer dilinoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl) Plandool-G: Dimer dilinoleyl bis(behenyl / isostearyl / phytosteryl) dimer dilinoleate Plandool-DP: Bisdiglyceryl polyacyladipate-2 Plandool-ISS: Phytosteryl isostearate Plandool-SUN: Sunflower seed oil fatty acid phytosteryl Plandool-MAS: Phytosteryl macadamiate 〇Plandool-LG1: Lauroyl glutamate di(phytosteryl / octyldodecyl / behenyl) Plandool-LG2: Di(phytosteryl / octyldodecyl) lauroyl glutamate 〇Plandool-LG3: Lauroyl glutamate di(phytosteryl / octyldodecyl / behenyl) 〇Plandool-LG4: Lauroyl glutamate di(phytosteryl / octyldodecyl / behenyl) Tremoist-TP: Tremella fuciformis polysaccharide Tremoist-SL: Tremella fuciformis polysaccharide aqueous solution (1%) Erucalactone MCT: γ-docosalactone, tri(caprylic / capric acid)glyceryl Erucalactone DES: γ-docosalactone, diethyl sebacate STR-100W: Titanium oxide, hydrated silica FINEX-33W: Zinc oxide, hydrated silica DIS-AB-10W: Titanium oxide, hydrated silica, hydrogen dimethicone, water, 1,3-butylene glycol, PEG-9 dimethicone

Claims

1. The water-dispersed composition contains the following components (A) to (C), in which the mass ratio of components (A1) to (A2) is 6:4 to 1:9, and the content of component (A3) in component (A) is 1 to 36 mass%. (A) A lipid composition comprising the following components (A1) to (A3): (A1) One or more selected from the group consisting of mono- or diesters of fatty acids having 8 to 22 carbon atoms and polyglycerols having a polymerization degree of 6 to 22, and monoesters of fatty acids having 8 to 22 carbon atoms and sucrose. (A2) Phospholipid (A3) One or more poorly soluble components selected from ceramides, sterols, carotenoids, tocopherols, lipoic acid, and coenzyme Q10 (B) Polyhydric alcohol (C) Water

2. 2. The water-dispersed composition according to claim 1, wherein the component (A3) is a ceramide.

3. 3. The water-dispersed composition according to claim 2, wherein the component (A) forms a lipid membrane structure in the water-dispersed composition.

4. A cosmetic or skin external preparation comprising the aqueous dispersion composition according to any one of claims 1 to 3.

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