Gas generation patch

Abstract

To provide a gas generation patch capable of sustainedly releasing a medical gas.SOLUTION: Provided is a gas generation patch 100 that includes a first layer 110, a plurality of porous carriers 120, and a reactant 130. According to an embodiment of the present invention, the reactant 130 is disposed in the pores of the plurality of porous carriers 120, the plurality of porous carriers 120 being disposed on the surface of the first layer 110. In another embodiment of the invention, the gas generation patch further comprises a colloid disposed on the surface of the first layer, and the plurality of porous carriers are uniformly dispersed in the colloid. In another embodiment of the invention, the gas generation patch further includes a second layer disposed on the plurality of porous carriers relative to the first layer.SELECTED DRAWING: Figure 1A

Description

Technical Field

[0001] The present invention relates to a medical patch, and more particularly to a gas generating patch capable of gradually releasing a medical gas.

Background Art

[0002] Treating various diseases and symptoms using gases is a widely used medical technique. Common medical gases include oxygen gas, hydrogen gas, carbon dioxide, nitric oxide, nitrous oxide, nitrogen oxides, etc., and appropriate gas treatment can be provided to patients through medical devices such as breathing masks, nasal cannulas, endotracheal tubes, and ventilators.

[0003] However, these medical devices are not only large in size and energy-consuming, but also have potential safety risks in the provision of medical gases by high-pressure gas cylinders. The use of these medical devices requires the operation and supervision of trained medical professionals, and as a result, there are significant limitations in the actual application of gas therapy.

[0004] In view of such circumstances, in this technical field, there is a need for a medical product that is easy and safe to operate and can stably provide gas therapy at any time and anywhere.

Summary of the Invention

[0005] This summary is intended to provide a simplified overview of the present disclosure to provide the reader with a basic understanding of the present disclosure. This summary is not an extensive overview of the present disclosure and is not intended to identify key / essential elements of embodiments of the present invention or to delineate the scope of the present invention.

[0006] In the present invention, a gas generation patch that reacts with ambient water to generate gas is provided. According to an embodiment of the present invention, the gas generation patch includes a first layer, a plurality of porous carriers, and a reactant. The first layer is made of a first polymer. The first polymer is selected from the group consisting of polyethylene (PE), polyurethane (PU), polyethylene terephthalate (PET), and polypropylene (PP). The plurality of porous carriers are dispersedly provided on the surface of the first layer. Each porous carrier has a plurality of pores. The reactant is provided in each pore of the porous carrier and includes metal peroxide and metal hydroxide. The gas generated by the reaction of the reactant with ambient water diffuses in a direction opposite to the first layer.

[0007] In one embodiment of the present invention, the gas is hydrogen gas and oxygen gas.

[0008] According to some embodiments of the present invention, the porous carrier is made of diatomaceous earth, PE, ethylene-vinyl acetate copolymer, or a combination thereof.

[0009] According to an embodiment of the present invention, each pore has a pore diameter of 1,200 - 6,000 nm.

[0010] According to some preferred embodiments of the present invention, an acidic catalyst is coated on the surface of the porous carrier. In one embodiment of the present invention, the acidic catalyst is selected from the group consisting of citric acid, lactic acid, phytic acid, oxalic acid, hydrochloric acid, and silicic acid.

[0011] According to an alternative embodiment of the present invention, the gas generation patch further includes a second layer provided on a plurality of porous carriers with respect to the first layer. The second layer has a plurality of pores. In an exemplary embodiment of the present invention, the second layer is made of a second polymer. The second polymers are each selected from the group consisting of polyethylene, polyurethane, polyethylene terephthalate and polypropylene.

[0012] In another alternative embodiment of the present invention, the gas generation patch further includes a colloid provided on the surface of the first layer and covering a plurality of porous carriers. The plurality of porous carriers are uniformly dispersed in the colloid. In one embodiment of the present invention, the plurality of porous carriers are present in the colloid in an amount of 5 wt% - 70 wt% by weight.

[0013] Optionally, the colloid is selected from the group consisting of thermoplastic polyurethane, polyvinyl alcohol, polyacrylic acid (PAA), nitrocellulose, silica gel, collagen fiber and algin.

[0014] According to some embodiments of the present invention, the metal peroxide is selected from the group consisting of lithium peroxide, sodium peroxide, potassium peroxide, magnesium peroxide, calcium peroxide and barium peroxide. The metal hydroxide is selected from the group consisting of lithium hydroxide, sodium hydroxide, potassium hydroxide, calcium hydroxide and barium hydroxide. According to an example of the present invention, the metal peroxide is calcium peroxide and the metal hydroxide is calcium hydroxide.

[0015] In a non-essential embodiment of the present invention, the reactant further includes carbonates, dioxidonitrates and combinations thereof.

[0016] Referring to the following embodiments, those with ordinary knowledge in the technical field to which the present invention pertains can easily understand the basic spirit of the present invention, its other objectives, as well as the technical means and embodiments adopted by the present invention.

Brief Description of the Drawings

[0017] To make the above content, other objectives, features, advantages, and embodiments of the present invention clearer, the accompanying drawings will be described below.

Fig. 1A

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[0018] According to general conventions, various features and components in the figures are not drawn to a certain scale, but are drawn in a way that best shows the specific features and components related to the present invention. Furthermore, the same or similar members / components are denoted by the same or similar reference signs in different drawings. Modes for Carrying Out the Invention

[0019] To describe the present invention in more detail and completely, the embodiments and specific examples of the present invention will be illustratively described below. However, this is not the only form for implementing or using the specific examples of the present invention. The embodiments include the features of many specific examples, as well as the steps and sequences for constructing and operating these specific examples. However, the same or equivalent functions and steps can also be achieved by other examples.

[0020] I. Definitions For the sake of convenience, specific terms used in this specification, the examples, and the appended claims are collectively set forth herein. Unless otherwise defined herein, scientific and technical terms used in this specification have the same meaning as commonly understood and customarily used by those of ordinary skill in the technical field to which the present invention pertains. In addition, as used herein, singular nouns include the plural form of the noun, and plural nouns include the singular form of the noun, provided that there is no contradiction in the context. Specifically, in this specification and the claims, unless otherwise indicated by the context, the singular forms "a" and "an" include multiple reference values. Also, in this specification and the scope of the patent application, the expressions "at least one" and "one or more" are synonymous and both represent one, two, three or more, or a large number.

[0021] The numerical ranges and parameters used to define the broader scope of the present invention are approximate values, but the relevant numerical values in specific examples are shown as accurately as possible. However, every numerical value inherently includes the standard deviation resulting from the individual test methods used. Here, "about" generally means that the actual value is within plus or minus 10%, 5%, 1%, or 5% of the specified value or range. Alternatively, the term "about" means that the actual value falls within the acceptable standard error of the average value determined by those of ordinary skill in the technical field to which the present invention pertains. Except for experimental examples or unless otherwise specified, all ranges, amounts, numerical values, and percentages (such as for explaining the amount of materials, the length of time, temperature, operating conditions, quantitative ratios, and other similar things) used in this specification are all modified by "about". Therefore, unless otherwise stated to the contrary, the numerical parameters disclosed in this specification and the appended claims are approximate values and can be changed as needed. At least, it should be understood that these numerical parameters mean the values obtained by applying the number of significant digits displayed and ordinary rounding. The numerical ranges here represent from one endpoint to the other endpoint or between both endpoints, and unless otherwise specified, the numerical ranges mentioned here include the endpoints.

[0022] In this specification, "ambient water" refers to water that exists as a gas in the environment, which may be water vapor present in the air or water vapor released by organisms. For example, it may refer to water vapor generated by the evaporation of sweat emitted from the human body in a hot environment or after activity. In this specification, "ambient water" refers to the moisture generated by a living body in a sealed space (for example, the microspace between the patch and the skin, or the space between the mask and the mouth) formed after the gas generation patch is attached to the user's skin surface or wrapped around a specific part.

[0023] In this specification, "venthole" refers to an open or permeable pore structure, and gas and / or liquid can be selectively passed through according to the size, shape, density, and distribution pattern of the pores. Generally, it is often used in fabrics, packaging, medical supplies (such as bandages and masks), building materials (such as breathable bricks), etc. The gas generation patch of the present invention is provided with a venthole through which only gas can pass, whereby the generation rate of gas is controlled by controlling the humidity inside the gas generation patch.

[0024] II Specific Embodiments In order to solve the time and space limitations of treatment devices for production in the current gas treatment field, the present invention provides a gas generation patch that allows a patient to operate by himself at a location outside a medical institution according to a doctor's prescription after receiving simple guidance, and can receive stable gas treatment for a long time without affecting the schedule of life and work, and can obtain the best results.

[0025] In the present invention, it is an object to provide a gas generation patch that is attached to the skin or respiratory system of a user, reacts with moisture around a sealed space to generate a specific gas having a therapeutic effect, and provides necessary gas treatment. For example, a user attaches the gas generation patch to the arm, torso, face, or leg according to the usage requirement to form a sealed space, and reacts with water vapor generated by evaporation of sweat to generate a specific gas in this sealed space, establish a sufficient partial pressure in the body for a physiological reaction, and the gas can permeate through the skin or respiratory system by a transdermal drug delivery system to achieve the purpose of local or systemic treatment.

[0026] FIG. 1A is a schematic diagram of a gas generation patch 100 according to an embodiment of the present invention. FIG. 1B is a cross-sectional view of the gas generation patch 100 of FIG. 1A. FIG. 2 is an enlarged schematic diagram of the porous carrier 120 on the gas generation patch 100 of FIG. 1A. As shown in FIGS. 1A, 1B, and 2, the gas generation patch 100 structurally includes a first layer 110 made of a first polymer having surfaces 111 and 112, a plurality of porous carriers 120 dispersed on the surface 111 of the first layer 110 having a plurality of pores 121, and a reactant 130 provided in these pores 121.

[0027] When the gas generation patch 100 is attached to the skin surface of a user, specifically, the porous carrier 120 contacts the user's skin, and the first layer 110 covers the porous carrier 120 and a part of the skin, whereby a sealed space is formed at the affected part. The gas generated by the gas generation patch 100 accumulates in the sealed space and gradually reaches a predetermined gas concentration, and the gas diffuses into the tissue due to the gas partial pressure power. To achieve the above object, the first layer 110 is made of a material that is neither breathable nor waterproof (i.e., the first polymer), whereby a sealed space is formed. In addition, since the gas generation patch 100 of the present invention generates a target gas by the reaction of ambient moisture and the reactant 130, in order to control the reaction rate and avoid excessive moisture from entering from the surface 112 and contacting the reactant 130, the first layer 110 needs to have waterproof characteristics. Thus, in order to meet the requirements of waterproof and airtight, in an embodiment of the present invention, the first polymer is selected from the group consisting of PE, PU, PET, and PP. In a specific embodiment of the present invention, the first polymer is PU. In another embodiment, the first polymer is PE. Optionally, the first layer 110 may be made of a laminated nonwoven fabric. It is a cloth layer having waterproof and gas barrier properties formed by bonding the first polymer to the nonwoven fabric by a method such as adhesion or hot pressing. For example, PP laminated nonwoven fabric or PE laminated nonwoven fabric may be mentioned.

[0028] In a preferred embodiment, a plurality of porous carriers 120 are actually provided at the central portion of the first layer 110 (for example, as shown in FIG. 1), whereby the edge of the surface 111 of the first layer 110 can be directly attached to the skin, and it is ensured that the generated therapeutic gas does not leak into the air from the edge of the gas generation patch 100.

[0029] As shown in FIG. 2, in order to enable the gas generation reaction to proceed smoothly, taking advantage of the property that the porous material has many pores 121 and the pores 121 communicate with each other, a natural or artificial porous material is used as the carrier of the gas generation patch 100 of the present invention (i.e., the porous carrier 120) to carry the reactants for gas generation (i.e., the reactant 130), or by applying this reactant 130 to the porous carrier 120, different reactants 130 are aggregated. In this way, each porous carrier 120 can form an independent reaction system. The structure of the pores 121 of the porous carrier 120 can have the effect of controlling the reaction rate by making it difficult for moisture to contact the reactant 130.

[0030] The porous carrier 120 may be arbitrarily selected from natural or artificial porous materials that are known in the art and do not react with the reactant 130 of the present invention. In an embodiment of the present invention, the porous carrier 120 is made of diatomaceous earth, PE, vinyl acetate copolymer, or a combination thereof.

[0031] The gases that can be produced by the gas generation patch 100 of the present invention and that exhibit specific therapeutic effects when applied in the medical field include, but are not limited to, oxygen gas, carbon dioxide, hydrogen gas, nitric oxide, nitrous oxide, helium, nitrogen dioxide, etc. According to an embodiment of the present invention, the gas generation patch 100 of the present invention can generate hydrogen gas and oxygen gas. In another embodiment of the present invention, in addition to hydrogen gas and oxygen gas, the reactant 130 can also generate carbon dioxide and / or nitric oxide. Those skilled in the art can select the reactant 130 and provide appropriate catalysts and reaction conditions (e.g., hydrogen ion index) so that the gas generation patch 100 can generate the desired gas according to the actual needs (e.g., the type of disease to be treated and the individual's condition).

[0032] According to an embodiment of the present invention, the reactant 130 includes a metal peroxide and a metal hydroxide that each react with surrounding moisture to generate oxygen gas and hydrogen gas. According to some embodiments of the present invention, the metal peroxide is selected from the group consisting of lithium peroxide, sodium peroxide, potassium peroxide, magnesium peroxide, calcium peroxide, and barium peroxide, and the metal hydroxide is selected from the group consisting of lithium hydroxide, sodium hydroxide, potassium hydroxide, calcium hydroxide, and barium hydroxide. Those skilled in the art can select specific metal peroxides and metal hydroxides according to actual needs. For example, when attempting to generate a relatively large amount of oxygen gas and / or hydrogen gas, peroxides or hydroxides containing metals with relatively high activity (such as sodium or potassium) can be used as reactants.

[0033] Furthermore, the metal peroxide and the metal hydroxide may be peroxides and hydroxides containing the same or different metals. For example, magnesium peroxide may be used as the metal peroxide and calcium hydroxide may be used as the metal hydroxide. In one example of the present invention, the metal peroxide and the metal hydroxide contain the same metal (i.e., calcium) and are calcium peroxide and calcium hydroxide, respectively.

[0034] According to a specific example of the present invention, the reaction mechanism for generating oxygen gas from the reactant 130 is shown in Formula I or Formula II. The reaction mechanism for generating hydrogen gas is shown in Formula III or Formula IV. In the formulas, X is a divalent metal such as calcium or magnesium, and Y is a monovalent metal such as sodium or potassium. As shown in Formula I or Formula II, the metal peroxide reacts with moisture to generate oxygen gas. As shown in Formula III or Formula IV, the metal hydroxide reacts with moisture and aluminum powder to generate hydrogen gas. 2XO 2 +2H 2 O→2X(OH) 2 +O 2 (Formula I) 2Y 2 O 2 +2H 2 O→4Y(OH)+O2 (Formula II) X(OH) 2 +2Al + 6H 2 O → X(Al(OH) 4 ) 2 +3H 2 (Formula III) 2Y(OH) + 2Al + 2H 2 O → 2YAlO 2 +3H 2 (Formula IV)

[0035] As shown in Formulas I-IV, the metal peroxide can generate oxygen gas and metal hydroxide by reacting with moisture. The metal hydroxide can generate hydrogen gas by reacting with water. Therefore, by selecting appropriate metal peroxide and metal hydroxide, the hydrogen generation and oxygen generation processes become a series of reactions, and the gas generation efficiency of the chemical reaction agent 130 can be optimized.

[0036] In another embodiment of the present invention, based on the reaction principles of Formulas III and IV, the reactions of Formulas III and IV are carried out using silicon, magnesium, or iron instead of aluminum, and hydrogen gas can be generated.

[0037] Optionally, the reaction agent 130 of the present invention may further contain carbonates, nitrites, and combinations thereof to generate carbon dioxide and / or nitric oxide.

[0038] As described above, the gas generation patch 100 of the present invention can provide various therapeutic gases through various gas generation reactions. In order to avoid unwanted reactions between different reactants and products, different reactants 130 are provided on different porous carriers 120 such that each porous carrier 120 becomes an independent gas generation system. For example, each porous carrier 120 may be an oxygen generation system (i.e., a porous carrier containing metal peroxide), a hydrogen generation system (i.e., a porous carrier containing metal hydroxide), a carbon dioxide generation system (i.e., a porous carrier containing carbonate), and a nitric oxide generation system (i.e., a porous carrier containing nitrite), respectively. However, based on the reaction mechanisms of oxygen generation and hydrogen generation as described above (i.e., Formulas I-IV), the oxygen generation system and the hydrogen generation system can be combined, i.e., the metal peroxide and the metal hydroxide can be provided on the same porous carrier, whereby the gas generation efficiency of the gas generation patch 100 can be optimized.

[0039] In some embodiments of the present invention, the pores 121 on the porous carrier 120 preferably have a pore diameter of 1,200 - 6,000 nm for carrying the reactant 130. The porous carrier 120 may be in the form of a sheet, granular, irregular shape, or any structure that does not affect the occurrence of the reaction or inhibits the entry of moisture.

[0040] Optionally, an acidic catalyst is additionally applied to the surface of the porous carrier 120 to adjust the pH of the reaction environment within the porous carrier 120. The pH may be maintained between 4 - 9. The acidic catalysts applicable to the porous carrier 120 of the present invention include, but are not limited to, citric acid, lactic acid, phytic acid, oxalic acid, hydrochloric acid, and silicic acid. According to an embodiment of the present invention, the acidic catalyst is citric acid.

[0041] In an alternative embodiment of the present invention, the purpose of maintaining the pH may be achieved by adding a solid acid to the reactant 130. The solid acid includes solid citric acid, solid lactic acid, solid phytic acid, solid oxalic acid, solid hydrochloric acid, solid silicic acid, etc.

[0042] When storing the gas generation patch 100 of the present invention, it can be packaged with an airtight material to prevent contact between moisture in the air and the reactant 130. During use, simply remove the airtight packaging and attach the gas generation patch 100 to the affected area. The gas generation patch 100 reacts with the water vapor evaporated from the body surface and supplies gas to the skin in a specific direction (i.e., in the direction opposite to the first layer 110).

[0043] Figures 3A and 3B are schematic diagrams of the layer structure arrangements of the gas generation patches 300a and 300b according to two different embodiments of the present invention, respectively.

[0044] As shown in Figure 3A, the gas generation patch 300a is substantially the same as the arrangement relationship of each element of the gas generation patch 100. Specifically, the gas generation patch 300a includes a waterproof and breathable first layer 310a and a plurality of porous carriers 320a provided on the surface 311a of the first layer 310a. The pores of the porous carrier 320a contain a reactant 330a that generates gas. The gas generation patch 300a further includes a colloid 340, and the colloid 340 is provided on the same surface of the plurality of porous carriers 320a and the first layer 310a. In this case, it is different from the gas generation patch 100 in that the plurality of porous carriers 320a are uniformly dispersed in the colloid 340.

[0045] Since the colloid 340 is particles floating in a continuous medium and interact to form a special state of matter with pores, the porous carrier 320a is wrapped in the colloid 340, and by controlling the contact rate between moisture and the reactant 330a through the pores of the colloid 340, the gas generation rate can be controlled, and the purpose of slow release of gas can be achieved.

[0046] The material of the colloid 340 can be selected according to the common knowledge in the technical field. The colloid 340 may be an oil-based or water-based colloid formed of an organic or inorganic polymer. According to some embodiments of the present invention, the colloid 340 is selected from the group consisting of thermoplastic polyurethane, polyvinyl alcohol, polyacrylic acid, nitrocellulose, silica gel, collagen fiber, and algin. In order to avoid the reaction between the reactant 330a and the water in the colloid 340, it is preferable that the porous carrier 320a is coated with an oil-based colloid, for example, a colloid formed by coating nitrocellulose or silica gel and glycerin.

[0047] In one embodiment of the present invention, the porous carrier 320a is present in the colloid 340 in an amount of 5 wt% - 70 wt% by weight. For example, the porous carrier 320a is present in the colloid 340 in an amount of 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, or 70% by weight.

[0048] FIG. 3B is a schematic diagram of the arrangement of the layered structure of the gas generation patch 300b according to another embodiment of the present invention. As shown in FIG. 3B, the gas generation patch 300b includes a first layer 310b, a plurality of porous carriers 320b provided on the surface 311b of the first layer 310b, and a reactant 330b provided in the pores of the porous carrier 320b. The gas generation patch 300b is different from the above gas generation patch 100 or 300a in that it further includes a second layer 350 provided on the plurality of porous carriers 320b with respect to the first layer 310b. In other words, in the gas generation patch 300b, a plurality of porous carriers 320b are provided between the first layer 310b and the second layer 350.

[0049] The second layer 350 of the gas generation patch 300b (FIG. 3B) and the colloid 340 of the gas generation patch 300a (FIG. 3A) are both for controlling the contact rate between water vapor and the reactant. Therefore, the second layer 350 has a plurality of ventilation holes 351 through which water vapor can enter and the generated gas can diffuse to the user's body surface.

[0050] To avoid the rapid occurrence of gas reactions caused by liquid water coming into contact with the reactant 330b through the second layer 350, the second layer 350 is made of a second polymer having waterproof properties and preferably has a structure with a plurality of ventilation holes 351 on a microscopic scale according to the common knowledge in the art. The second polymer applied to the second layer 350 of the present invention includes, but is not limited to, PE, PU, PET, or PP. Those skilled in the art should understand that merely exemplarily listing several suitable polymers does not limit the materials for manufacturing the second layer 350. Furthermore, since one surface of the second layer 350 comes into contact with the user's skin, the second layer 350 may be made of a skin-friendly material having waterproof breathability.

[0051] Example Example 1: Manufacture of the gas generation patch of the present invention To measure the gas generation efficiency by a plurality of independent gas generation systems, PU was selected as the first polymer (i.e., the material of the first layer), a porous carrier was made of diatomaceous earth, potassium peroxide and calcium hydroxide were used as reactants for hydrogen generation and oxygen generation respectively, and citric acid was applied to the porous carrier, thereby manufacturing the gas generation patch of the present invention.

[0052] Example 2: Analysis of the gas generation efficiency of the gas generation patch of the present invention

[0053] The gas generation patch of the present invention manufactured in Example 1 and a dropper containing 5 ml of water were placed in a sealed container and evacuated to a negative pressure of -0.2 kg / cm 2 By evacuating to this level, the water in the dropper flowed out and became water vapor, and the gas generation patch reacted with the water vapor to generate gas.

[0054] 2.1 Total gas generation amount The total gas generation amount of the gas generation patch of the present invention was measured by the water displacement method. The results are shown in Table 1. Table 1: Changes in the concentration of oxygen gas in the sealed container

Table 1

[0055] As can be seen from the results in Table 1, the total gas generation amount of the gas generation patch of the present invention within 40 minutes was 4 ml.

[0056] 2.2 Gas generation efficiency Gas generation tests were conducted on the gas generation patch of Example 1 for 4 hours and 12 hours respectively. During the test, the concentrations of oxygen gas and hydrogen gas in the container were measured and recorded every 10 minutes using a handheld oxygen gas analyzer and a handheld hydrogen gas analyzer. The results are shown in FIGS. 4A and 4B.

[0057] FIG. 4A is a curve showing the change in the concentration of oxygen gas and hydrogen gas in the container for 4 hours. As can be seen from FIG. 4A, the initial oxygen content in the container was 16.23%, the oxygen content after the reaction was 17.72%, the total oxygen generation amount after conversion was about 16,400 ppm, the average oxygen generation rate was 68.3 ppm / minute, the total hydrogen generation amount was about 70.7 ppm, and the average hydrogen generation rate was 0.3 ppm / minute.

[0058] The concentrations of oxygen gas and hydrogen gas in the container both increased slowly within 4 hours, indicating that the gas generation patch of the present invention can stably release oxygen gas and hydrogen gas over a long period within 4 hours.

[0059] FIG. 4B is a curve showing the change in the concentration of oxygen gas and hydrogen gas in the container for 12 hours. As can be seen from FIG. 4B, the initial oxygen content in the container was 13.61%, the oxygen content after the reaction was 17.72%, the total oxygen generation amount after conversion was about 49,200 ppm, the average oxygen generation rate was 68.3 ppm / minute, the total hydrogen generation amount was about 165.6 ppm, and the average hydrogen generation rate was 0.23 ppm / minute.

[0060] The concentrations of oxygen gas and hydrogen gas in the container are both gradually increasing within 12 hours, indicating that the gas generation patch of the present invention can stably release oxygen gas and hydrogen gas over a long period within 12 hours.

[0061] From the above, the present invention enables a patient to perform gas treatment at a location outside the medical site without being restricted by time and space, can be attached to different sites according to the needs of the user, and restricts the contact rate of the reactant and moisture by a film having a colloid or pores, thereby achieving the purpose of sustained release of the necessary therapeutic gas. Therefore, the present invention provides a gas generation patch capable of obtaining an effective therapeutic effect.

[0062] The above description of the embodiments is shown merely as an example, and it should be understood that those skilled in the art can make various changes. The above specification, examples, and experimental results provide a complete description of the structure and use of the exemplary embodiments of the present invention. Although various examples of the present invention have been disclosed in the above embodiments, they do not limit the present invention. Those having ordinary knowledge in the technical field to which the present invention pertains can make various changes and modifications without departing from the principles and spirit of the present invention. Therefore, the protection scope of the present invention shall be defined by the attached patent application.

[0063] Description of Reference Numerals 100, 300a, 300b Gas generation patch 110, 310a, 310b First layer 111, 112, 311a, 311b Surface 120, 320a, 320b Porous carrier 121 Pore 130, 330a, 330b Reactant 340 Colloid 350 Second layer 351 Vent hole

Claims

1. A gas generating patch that generates gas in response to ambient water, the patch comprising a first layer, a plurality of porous carriers, and a reactant; The first layer is made of a first polymer, and the first polymer is selected from the group consisting of polyethylene, polyurethane, polyethylene terephthalate, and polypropylene; The plurality of porous carriers are provided in a dispersed manner on a surface of the first layer, and each of the porous carriers has a plurality of pores; The reactants are provided in each of the pores, and the reactants include a metal peroxide and a metal hydroxide. A gas generating patch, wherein the gas generated by the reaction of the reactant with the surrounding moisture diffuses in a direction opposite to the first layer.

2. 2. The gas generating patch of claim 1, wherein the gas is hydrogen gas and oxygen gas.

3. 2. The gas generating patch of claim 1, wherein each of said pores has a pore size of 1,200-6,000 nm.

4. 2. The gas generating patch according to claim 1, wherein the porous carriers are made of diatomaceous earth, polyethylene, vinyl acetate copolymer or a combination thereof.

5. The gas generating patch of claim 1 , wherein an acid catalyst is applied to a surface of each of said porous carriers.

6. 6. The gas generating patch of claim 5, wherein the acid catalyst is selected from the group consisting of citric acid, lactic acid, phytic acid, oxalic acid, hydrochloric acid and silicic acid.

7. 2. The gas generating patch of claim 1, further comprising a second layer, said second layer being disposed on said plurality of porous carriers relative to said first layer, said second layer having a plurality of vent holes.

8. 8. The gas generating patch of claim 7, wherein the second layer is made of a second polymer, the second polymer being selected from the group consisting of polyethylene, polyurethane, polyethylene terephthalate, and polypropylene, respectively.

9. 2. The gas generating patch of claim 1, further comprising a colloid provided on said surface of said first layer and covering said plurality of porous carriers, said plurality of porous carriers being uniformly dispersed within said colloid.

10. 10. The gas generating patch of claim 9, wherein said plurality of porous carriers are present in said colloid in an amount of 5 wt %-70 wt % by weight.

11. 10. The gas generating patch according to claim 9, wherein the colloid is selected from the group consisting of thermoplastic polyurethane, polyvinyl alcohol, polyacrylic acid, nitrocellulose, silica gel, collagen fiber, and algin.

12. 2. The gas generating patch according to claim 1, wherein the metal peroxide is selected from the group consisting of lithium peroxide, sodium peroxide, potassium peroxide, magnesium peroxide, calcium peroxide, and barium peroxide, and the metal hydroxide is selected from the group consisting of lithium hydroxide, sodium hydroxide, potassium hydroxide, calcium hydroxide, and barium hydroxide.

13. 13. The gas generating patch of claim 12, wherein said metal peroxide is calcium peroxide and said metal hydroxide is calcium hydroxide.

14. 10. The gas generating patch of claim 1, wherein the reactant further comprises a carbonate, a nitrite, and combinations thereof.

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