Biological information measuring apparatus

Abstract

To provide a biological information measuring apparatus capable of accommodating to measuring object persons with various arm thicknesses and improving detection accuracy of electrocardiographic waveform.SOLUTION: A biological information measuring apparatus comprises at least a body part, and the body part includes a first arm part and a second arm part respectively curving from the body part upper portion to a body part lower portion and extending to the left and right. Ends of the first and second arm parts are separated from each other and at least any end side of the first and second arms includes an electrode for measuring biological information. Alternatively, at least any of the first and second arm parts is deviated and extends outward in the longitudinal direction at the body part lower portion. Alternatively, at least a part of both ends of the first and second arms extends to such a length as to overlap each other in the longitudinal direction at the body part lower portion. Alternatively, at least any of the ends of the first and second arms is further curved from the body part lower side toward the body part upper side.SELECTED DRAWING: Figure 1

Description

Technical Field

[0001] The present disclosure relates to a biological information measurement device for measuring biological information of a subject.

Background Art

[0002] Continuously measuring blood pressure and detecting early onset of diseases and changes in disease conditions from the changes are effective for health management. Therefore, a biological information measurement device for continuously measuring biological information such as blood pressure without applying pressure to the arm or the like with a cuff or the like has been proposed.

[0003] For example, in Patent Document 1, a wrist-wearable type wearable device that includes an optical sensor module and a motion sensor and is capable of measuring biological information such as the subject's heartbeat, stress, and blood oxygen saturation based on the reflected light detected by the optical sensor module is illustrated with a wearing configuration in which it is worn on the wrist by a belt-type strap.

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0005] However, in a configuration in which it is worn on the wrist with a belt like a conventional wristwatch as exemplified in Patent Document 1, it is difficult to wear, for example, when the hand is paralyzed, and an information measurement device that can be easily worn is required.

[0006] On the other hand, as an idea for facilitating wearing, it is also conceivable to use a wristband-type information measurement device (only the term "wristband type" is described in Patent Document 1). In such a wristband type, since it is necessary to create a gap between the wearing portion and the measurement device in order to easily pass the wrist through the wristband portion, the configuration required to obtain measurement information in close contact with the wrist, such as an optical sensor module, is contrary to the configuration required, and a more complex mechanism is required to make these compatible.

[0007] Therefore, an object of the present invention is to provide a biological information measurement device that can accommodate subjects with various wrist thicknesses and can improve the detection accuracy of electrocardiogram waveforms.

Means for Solving the Problems

[0008] In order to solve the above problems, the biological information measurement device of the present invention is a biological information measurement device having at least a main body portion, and the main body portion includes a first arm portion and a second arm portion that are curved from the upper part to the lower part of the main body portion and extend left and right, and the ends of the first arm portion and the second arm portion are separated from each other, and at least one of the ends of the first arm portion and the second arm portion is provided with an electrode for measuring biological information.

Effects of the Invention

[0009] According to the above biological information measurement device, it is possible to provide a biological information measurement device that can accommodate subjects with various wrist thicknesses and can improve the detection accuracy of electrocardiogram waveforms.

Brief Description of the Drawings

[0010]

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Mode for Carrying Out the Invention

[0011] The contents of the embodiments of the present invention will be listed and described. The biological information measurement device according to the embodiment of the present invention has the following configuration. [Item 1] A biological information measurement device having at least a main body part, The main body part includes a first arm part and a second arm part that are curved from the upper part of the main body part to the lower part of the main body part and extend left and right, The ends of the first arm part and the second arm part are separated from each other, An electrode for measuring biological information is provided on at least one end side of the first arm part and the second arm part, A biological information measurement device characterized by the above. [Item 2] At least one of the first arm part and the second arm part extends while being displaced outward in the front-rear direction at the lower part of the main body part, The biological information measurement device according to claim 1, characterized by the above. [Item 3] At least a part of both ends of the first arm part and the second arm part extends to a length that overlaps with each other in the front-rear direction at the lower part of the main body part, The biological information measurement device according to claim 2, characterized by the above. [Item 4] At least one of the ends of the first arm part and the second arm part is further curved from the lower side of the main body part toward the upper side of the main body part, The biological information measuring device according to any one of claims 1 to 3, characterized by the above. [Item 5] The materials of the first arm part and the second arm part include a thermoplastic elastomer. The biological information measuring device according to any one of claims 1 to 4, characterized by the above. [Item 6] The thermoplastic elastomer includes at least a polyether block amide. The biological information measuring device according to claim 5, characterized by the above. [Item 7] The main body part does not have a display part. The biological information measuring device according to any one of claims 1 to 6, characterized by the above. [Item 8] Two of the electrodes are provided on the same end side of the end sides of the first arm part and the second arm part. The biological information measuring device according to any one of claims 1 to 6, characterized by the above. [Item 9] One of the electrodes is provided on each of the different end sides of the end sides of the first arm part and the second arm part. The biological information measuring device according to any one of claims 1 to 6, characterized by the above. [Item 10] Two of the electrodes are provided on each of the different end sides of the end sides of the first arm part and the second arm part. The biological information measuring device according to any one of claims 1 to 6, characterized by the above. [Item 11] An amplifier for amplifying the potential difference between two electrodes provided on the same end side is provided. The biological information measuring device according to any one of claims 1 to 10, characterized by the above. [Item 12] The main body part has a reference voltage terminal for obtaining a reference voltage at the upper part of the main body part, and inputs the reference voltage to the amplifier. The biological information measuring device according to claim 11, characterized by the above. [Item 13] The reference voltage terminal is connected to a thermistor that measures the skin temperature of the person being measured. The biological information measuring device according to claim 12, characterized in that. [Item 14] The main body part includes an optical sensor module that measures the pulse wave of the person being measured. The biological information measuring device according to any one of claims 1 to 13, characterized in that. [Item 15] The main body part includes a communication part that outputs the measured biological information to the outside. The biological information measuring device according to any one of claims 1 to 14, characterized in that.

[0012] Hereinafter, this embodiment will be described. Note that the embodiment described below does not unduly limit the content of the present invention described in the claims. Also, not all of the configurations described in this embodiment are essential constituent elements of the present invention. In addition, the features shown in each embodiment can be applied to other embodiments as long as they do not contradict each other.

[0013] <Configuration> Using FIGS. 1-3, the biological information measuring device 100 in this embodiment and the arm, which is the measurement site of the person being measured, will be described. FIG. 1(A) shows a state where the biological information measuring device 100 is worn on the left arm of the person being measured. FIG. 1(B) shows a perspective view of the radial artery and ulnar artery of the left arm of the person being measured, and shows the positional relationship between the radial artery, the ulnar artery, and the electrodes of the biological information measuring device 100. FIG. 1(C) is a diagram showing the positional relationship between the arm of the person being measured, the electrodes of the biological information measuring device 100, and the optical sensor. FIG. 2 is a perspective view of the biological information measuring device 100. FIG. 3 is a six-sided view of the biological information measuring device 100. In FIG. 2, for convenience, the direction in which the arm of the biological information measuring device 100 is inserted is defined as the front-rear direction, the direction on the side of the upper surface part 102 and the direction opposite to the arm is defined as the up-down direction, and the direction in which the first arm part 131 and the second arm part 132 extend from the upper part of the main body part 101 is defined as the left-right direction.

[0014] As shown in FIGS. 1-3, the biological information measuring device 100 includes a main body portion 101 and an upper surface portion 102. The main body portion 101 includes a first arm portion 131 and a second arm portion 132 that are curved from the upper part of the back of the hand side of the main body portion 101 along the wrist of the subject and extend to the lower part of the main body portion 101, respectively. The ends of the first arm portion 131 and the second arm portion 132 are separated from each other and have a non-circular ring shape as a component (that is, it does not prevent the surfaces of both ends of the first arm portion 131 and the second arm portion 132 that are separated from each other from contacting each other to form a shape that can be called a circular ring). And at least one of the ends of the first arm portion 131 and the second arm portion 132 (both ends in FIGS. 2 and 3) may extend while being displaced outward in the front-rear direction at the lower part of the main body portion 101. In particular, as shown in the lower view of FIG. 3, at least a part of both ends of the first arm portion 131 and the second arm portion 132 may extend to a length such that they overlap each other in the front-rear direction. Further, at least one of the ends of the first arm portion 131 and the second arm portion 132 (the end of the first arm portion 131 in FIGS. 2 and 3) may be curved inward on the side of the inserted arm (from the lower side of the main body portion 101 to the upper side of the main body portion 101). The material of part or all of the biological information measuring device 100 (especially the material of the first arm portion 131 and the second arm portion 132) is not particularly limited, but is preferably a thermoplastic elastomer having elasticity and excellent processability, and particularly preferably a polyether block amide (PEBA). And, for example, at least a part of at least one of the main body portion 101, the upper surface portion 102, the first arm portion 131, and the second arm portion 132 may be created by a molding process using the above-mentioned material, and the biological information measuring device 100 may be configured by connecting the members created in this way to each other.

[0015] With such a configuration, when the arm of the subject is inserted between the first arm portion 131 and the second arm portion 132 of the main body portion 101, the first arm portion 131 and the second arm portion 132 can be elastically deformed and expanded at least in the left - right direction, so that it is possible to accommodate various arm sizes with one size. Also, since it is possible to configure it so as not to require fasteners (fixing tools) such as belts or surface fasteners, for example, even if the hand is paralyzed, it is easy to wear. Further, the ends of the first arm portion 131 and the second arm portion 132 are displaced and extended outward in the front - rear direction and extend to a length such that they overlap each other in the front - rear direction. Therefore, compared with the case of being annular like a bracelet, it is possible to take a sufficient length. For example, even when a thick arm is inserted into the biological information measuring device 100, each electrode (described later) provided on the end side of the first arm portion 131 and the second arm portion 132 can be arranged near the artery without being too far from the artery. Furthermore, since the ends of the first arm portion 131 and the second arm portion 132 are curved inward (from the lower side of the main body portion 101 to the upper side of the main body portion 101) on the side of the arm through which they are inserted, even when the first arm portion 131 and the second arm portion 132 are elastically deformed and expanded at least in the left - right direction, the structure is such that it is easy to catch on the subject's arm, and each electrode provided on the end side of the first arm portion 131 and the second arm portion 132 can be sufficiently in contact with the surface of the arm.

[0016] The upper surface portion 102 is provided outside the upper part of the main body portion 101 and may serve as a lid portion when storing a circuit board, a battery, etc. in the main body portion 101. Also, the upper surface portion 102 may have a display portion function. For example, it may have a time display function or a biological information display function. However, when the upper surface portion 102 is provided with a display portion function, since there are many necessary components and the main body portion 101 becomes large, it is more preferable not to have a display portion function when miniaturization is required. In that case, when the subject wants to confirm his or her own biological information, communication may be performed between the biological information measuring device 100 and an external terminal device 200 (see FIG. 5), and the biological information may be displayed on the terminal device display portion 214 of the terminal device 200.

[0017] The main body 101 has a first electrode 121 and a second electrode 122 on the end side of the second arm part 132, a third electrode 123 and a fourth electrode 124 on the end side of the first arm part 131, and includes a fifth electrode 125, a sixth electrode 126, an optical sensor module 111, etc. on the upper inner side of the main body 101. The sixth electrode 126 may be provided, for example, as a terminal for charging a battery, as a terminal for communication with an external device, may serve both purposes, or may be provided for other purposes.

[0018] As shown in FIG. 1(B), the radial artery 911 and the ulnar artery 912 pass through the arm of the subject to be measured. The radial artery 911 passes between the radius and the skin on the surface of the wrist, and the ulnar artery 912 passes between the ulna and the skin on the surface of the wrist. The radial artery 911 and the ulnar artery 912 branch from the brachial artery (not shown) in the upper arm.

[0019] As shown in FIGS. 1(B), 2, and 3, the first electrode 121 and the second electrode 122 are arranged side by side in the circumferential direction of the wrist in the vicinity of the radial artery 911 on the palm side of the wrist, and detect a potential linked to the electrocardiogram from the radial artery 911. The third electrode 123 and the fourth electrode 124 are arranged side by side in the circumferential direction of the wrist in the vicinity of the ulnar artery 912 on the palm side of the wrist, and detect a potential linked to the electrocardiogram from the ulnar artery 912. As shown in FIGS. 1(C), 2, and 3, the fifth electrode 125 is arranged on the back side of the wrist and detects the bio-reference potential. With such a configuration, with the fifth electrode 125 as the reference potential, the potential detected by at least one of the first electrode 121 or the second electrode 122, or at least one of the third electrode 123 or the fourth electrode 124 is measured by an amplifier (for example, an operational amplifier, etc.) over time, so that an electrocardiogram can be accurately obtained and an electrocardiogram waveform can be measured. Further, the fifth electrode 125 may be, for example, a ground potential. By using this, the fluctuation of the reference potential of the measurement can be suppressed, so that the detection accuracy of an electrocardiogram waveform with a minute change (inflection point) such as a T wave detected by at least one of the first to fourth electrodes can be improved.

[0020] Here, the number of electrodes for obtaining an electrocardiogram is not limited to five as described above, and may be appropriately increased or decreased as needed. Regarding this, modified examples of the electrodes will be described below.

[0021] <Modified Example 1 of Electrode> For example, if an electrocardiogram waveform with minute changes (inflection points) such as T waves can be sufficiently detected from at least any one of the first electrode 121 to the fourth electrode 124, a configuration without the fifth electrode 125 may be adopted.

[0022] <Modified Examples 2 and 3 of Electrode> The first electrode 121 to the fourth electrode 124 can be appropriately arranged near either the radial artery 911 or the ulnar artery 912 of the subject to be measured, for example, such that a biological information measuring device 100 of various sizes can be fabricated. In such a case, a configuration including any one of the first electrode 121 to the fourth electrode 124 (modified example 2), or a configuration including two electrodes, one for the radial artery 911 by either the first electrode 121 or the second electrode 122 and one for the ulnar artery 912 by either the third electrode 123 or the fourth electrode 124 (modified example 3), may be adopted.

[0023] <Modified Example 4 of Electrode> A configuration may also be adopted in which either one set (a total of two electrodes), such as one set of the first electrode 121 and the second electrode 122 for the radial artery 911, or one set of the third electrode 123 and the fourth electrode 124 for the ulnar artery 912, is used.

[0024] Here, in the configuration where one set is provided for at least either the radial artery 911 or the ulnar artery 912 as in the above-described embodiment and this modification example 4, for example, it may be a configuration that calculates the potential difference between both electrodes within one set. That is, for example, when the first arm part 131 and the second arm part 132 elastically deform and expand at least in the left-right direction, or when the biological information measurement device 100 rotates in the circumferential direction of the wrist and the position is displaced, the electrodes move away from the artery, so that it extremely approaches 0, and further, the influence of noise is likely to appear. Therefore, for example, when providing one electrode for the artery, the necessity of arranging it at an appropriate position increases. On the other hand, by arranging one set of electrodes side by side in the circumferential direction of the wrist with respect to the artery, for example, even if one electrode moves away from the artery, the other electrode can be arranged near the artery. Thus, the detection accuracy of the electrocardiogram waveform with minute changes (inflection points) such as T waves can be improved. Also, although the detected potential may become small, instead of the potential difference, it may be a configuration that calculates the average value of the potentials from both electrodes of one set as the electrocardiogram potential. Also, although the determination configuration may become complicated, instead of the potential difference, it may be a configuration that selects the potential of either electrode of one set of both electrodes as the electrocardiogram potential by comparing it with a reference potential for determination or comparing the potentials of both.

[0025] Also, as in the above-described embodiment and modification example 2, when obtaining two types for the radial artery 911 and the ulnar artery 912, it may be a configuration that calculates the average value of both as the electrocardiogram potential, compares it with a reference potential for determination, or compares the potentials (potential differences) of both, and employs the potential (potential difference) of either of the two types of electrodes for the detection of the electrocardiogram waveform.

[0026] Further, a configuration may be adopted in which a thermistor is connected to at least any one of the first electrode 121 to the sixth electrode 126 so that the skin temperature can be obtained. In particular, in view of the fact that the fifth electrode 125 is provided on the upper part of the main body 101, it is more preferable as an electrode provided with a thermistor than other electrodes. FIG. 4 shows an example in which a thermistor 1252 is connected to the fifth electrode 125 provided on the back surface 103 of the main body 101. For example, in the fifth electrode 125, the terminal 1251 is connected to a reference potential (for example, ground potential GND), and the thermistor 1252 may include a ground terminal 1253 and an output terminal 1254, respectively. The thermistor 1252 may be connected to the fifth electrode 125 via a thermally conductive adhesive 1255 having a high thermal conductivity, as illustrated in FIG. 4, or may be directly connected to the fifth electrode 125 (in particular, by making a recess on the back side of the fifth electrode 125 and inserting and fixing a part of the thermistor 1252). Thereby, since the heat of the skin is transmitted to the thermistor 1252 through an electrode that directly touches the skin of the person to be measured (for example, the fifth electrode 125 illustrated in FIG. 4), the skin temperature of the person to be measured can be measured.

[0027] As shown in Fig. 1(C), the optical sensor module 111 includes a light emitting unit 112 and a light receiving unit 113. The light emitting unit 112 includes, for example, a green light emitting LED, and the light receiving unit 113 is composed of a photodiode capable of receiving the light emitted from the light emitting unit 112. The light emitting unit 112 is not limited to a green light emitting LED, and may be a red light emitting LED, a blue light emitting LED, an infrared LED, etc., and may include a plurality of the same color or a plurality of types of LEDs. More specifically, for example, the light emitting unit 112 may be configured to include a total of four elements: two green light emitting LEDs, a red light emitting LED, and an infrared LED. Also, regarding the light receiving unit 113, the number corresponding to each LED included in the light emitting unit 112 may be provided, or may be provided in common for some LEDs. The light emitted from the light emitting unit 112 to the wrist is reflected inside the wrist and received by the light receiving unit 113. Based on the temporal change in the intensity of the light received by the light receiving unit 113, the pulse waveform can be measured due to the volume change of the blood vessels caused by the heartbeat of the subject to be measured. The pulse waveform that can be detected by this method is a photoelectric volume pulse waveform. The optical sensor module 111 is disposed on the back of the hand of the wrist, and is disposed at a position facing the first electrode 121 etc. with the wrist interposed therebetween. Thereby, the measurement sites of the electrocardiogram waveform measured by the first electrode 121 etc. and the photoelectric volume pulse waveform measured by the optical sensor module 111 can be separated. As a result, the pulse transit time PTT_SYS (Pulse Transit Time_Diastolic) during ventricular contraction and the pulse transit time PTT_DIA during ventricular dilation described later can be lengthened, and the reliability of the measurement can be improved.

[0028] Next, with reference to Fig. 5, the configuration and outline of a biological information measurement system 1 including a server device 400 that calculates the biological information of a subject based on the information from the biological information measurement device 100 in the first embodiment will be described. Note that Fig. 5 is a block diagram of the biological information measurement system 1 of the present embodiment.

[0029] As shown in FIG. 5, the biological information measurement system 1 of this embodiment is composed of a biological information measurement device 100, a terminal device 200, and a server device 400. The terminal device 200 and the server device 400 are configured to be connectable to a network 300 such as the Internet or a LAN. Note that the biological information measurement device 100 and the terminal device 200 may be integrally configured, or the biological information measurement device 100 may be provided with a network communication function that enables communication via the network 300, so that communication can be performed between the biological information measurement device 100 and the server device 400. Also, part or all of the arithmetic processing of predetermined biological information (biologically generated information) may be performed by the biological information measurement device 100 instead of the arithmetic operation by the server device 400. However, when the arithmetic operation is performed by the biological information measurement device 100, the arithmetic processing load becomes high, so there is a possibility that the biological information measurement device 100 may be enlarged or the cost may increase. Therefore, it is more preferable to perform the arithmetic operation by the server device 400.

[0030] The biological information measurement device 100 includes an electrocardiogram detection unit 110, a pulse wave detection unit 120, a measurement device control unit 140, a measurement device storage unit 150, a measurement device operation unit 160, and a measurement device communication unit 170. These functional units are realized by executing a predetermined program for the biological information measurement device 100.

[0031] Note that examples of biological information include electrocardiogram information and pulse wave information as biological measurement information, or blood pressure information as biologically generated information obtained from these. However, the biological information is not limited to these. By known methods, examples of biological measurement information include skin temperature information (body temperature information), acceleration information, and angular velocity information of the subject to be measured. Further, examples of biologically generated data obtained from these biological measurement information include heart rate information, blood oxygen content information, maximum oxygen uptake information, blood glucose level information, respiratory rate, body temperature information, step count information, step width information, center of gravity position information, posture information, stress information, exercise amount information, exercise load information, movement distance information, movement speed information, activity amount information, and operation information of a wearing site such as a hand or a leg of the subject to be measured.

[0032] The electrocardiogram detection unit 110 includes, for example, a first electrode 121 and a second electrode 122 for detecting the electrocardiogram of the radial artery, a third electrode 123 and a fourth electrode 124 for detecting the electrocardiogram of the ulnar artery, and a fifth electrode 125 for measuring the reference potential.

[0033] The pulse wave detection unit 120 includes an optical sensor module 111. The optical sensor module 111 is composed of the light emitting unit 112 and the light receiving unit 113 described above.

[0034] The measurement device control unit 140 includes an electrocardiogram measurement control unit 141 and a pulse wave measurement control unit 142. The electrocardiogram measurement control unit 141 detects, for example, at least one of the differences in the detected potentials from the first electrode 121 and the second electrode 122, or the differences in the detected potentials from the third electrode 123 and the fourth electrode 124, amplifies it using the reference potential of the fifth electrode 125, and adds time information to form an electrocardiogram waveform. The pulse wave measurement control unit 142 controls the light emission of the light emitting unit 112 of the pulse wave detection unit 120, and also receives the detection signal from the light receiving unit 113.

[0035] The measurement device storage unit 150 stores, for example, the electrocardiogram information received by the electrocardiogram measurement control unit 117, and also stores the pulse wave information received by the pulse wave measurement control unit 118. The electrocardiogram information includes electrocardiogram waveform information regarding an electrocardiogram waveform in which the electrocardiogram information received by the measurement device control unit 140 is continuously arranged, and measurement time information of the electrocardiogram waveform and the like is added. The pulse wave information is information regarding a photoelectric plethysmogram waveform in which the pulse wave information received by the pulse wave measurement control unit 142 is continuously arranged, and measurement time information of the photoelectric plethysmogram waveform and the like is added. The electrocardiogram information and the pulse wave information are transmitted to the terminal device 200 via the measurement device communication unit 170 described later, but can also be temporarily stored for reasons such as reducing the transmission frequency for power saving or when the communication connection with the terminal device 200 is interrupted.

[0036] The measurement device operation unit 160 is an operation unit for the subject or the like to perform operations such as powering on the biological information measurement device 100, starting and ending measurements.

[0037] The measurement device communication unit 170 is a communication interface for communicating between the biological information measurement device 100 and an external device such as the terminal device 200. The measurement device communication unit 170 transmits, for example, the electrocardiogram information received by the electrocardiogram measurement control unit 141, the pulse wave information received by the pulse wave measurement control unit 142, the electrocardiogram information and the pulse wave information stored in the measurement device storage unit 150 to the terminal device 200, or receives information for operating the biological information measurement device 100 from the terminal device 200. Bluetooth (registered trademark) is used as the communication means in this embodiment. As other communication means, Near Field radio Communication (NFC), Afero (registered trademark), Zigbee (registered trademark), Z-Wave (registered trademark), or wireless LAN etc. may be used. Or, a wired connection may be made using the sixth electrode 126.

[0038] The terminal device 200 includes a terminal device control unit 211, a terminal device storage unit 212, and a terminal device communication unit 213. The terminal device 200 is an information processing device such as a smartphone, a mobile phone, a PHS, or a PDA. Also, it may be a terminal device dedicated to the biological information measurement device instead of a general-purpose device such as a smartphone. These functional units are realized by executing a predetermined program of the terminal device 200.

[0039] The terminal device control unit 211 performs storage control of biological information such as electrocardiogram information and pulse wave information received by the terminal device communication unit 213 from the biological information measurement device 100 to the terminal device storage unit 212, or transmits biological information such as electrocardiogram information and pulse wave information from the terminal device storage unit 212 to the server device 400, or receives biological generation information calculated based on the biological measurement information by the server device 400.

[0040] The terminal device storage unit 212 stores biological information such as electrocardiogram information and pulse wave information received by the terminal device communication unit 213.

[0041] The terminal device communication unit 213 is a communication interface for communicating with the biological information measurement device 100 and the server device 400. It receives biological information such as electrocardiogram information and pulse wave information transmitted from the biological information measurement device 100, and also transmits setting information to the biological information measurement device 100 and request signals for biological information such as electrocardiogram information and pulse wave information. In addition, it transmits biological information such as electrocardiogram information and pulse wave information to the server device 400, and also receives request signals for biological information such as electrocardiogram information and pulse wave information from the server device 400. In this embodiment, the communication with the biological information measurement device 100 is the aforementioned Bluetooth (registered trademark), but other communication means may also be used. Also, the communication with the server device 400 can be performed via a network 301 such as the Internet by wireless LAN.

[0042] The terminal device display unit 214 displays biological information and abnormality notifications transmitted from the biological information measurement device 100 or the server device 400 in accordance with, for example, the rules of the application executed on the terminal device 200.

[0043] The server device 400 includes a server device control unit 411, a server device communication unit 412, and a server device storage unit 413.

[0044] The server device control unit 411 is configured to include a pulse wave propagation time calculation unit 421 as the first calculation unit and a biological information calculation unit 422 as the second calculation unit. The server device control unit 411 (the third calculation unit) calculates second-order differential data from the photoelectric plethysmogram waveform data. The pulse wave propagation time calculation unit 421 detects the R wave and the T wave from the waveform profile in the electrocardiogram information described later, and also detects the P wave and the D wave from the waveform profile in the photoelectric plethysmogram waveform data, and based on this information, calculates the pulse wave propagation time PTT_SYS during ventricular contraction and the pulse wave propagation time PTT_DIA during ventricular relaxation. Also, the biological information calculation unit 422 calculates blood pressure information from the acceleration pulse wave characteristic information based on the second-order differential data described later calculated by the server device control unit 411, the pulse wave propagation time PTT_SYS during ventricular contraction, and the pulse wave propagation time PTT_DIA during ventricular relaxation. Furthermore, the server device control unit 411 determines the health status of the subject based on the blood pressure information and issues an abnormality notification to the terminal device 200. When detecting the R wave and the T wave, the pulse wave propagation time calculation unit 421 may use the first-order differential data or the second-order differential data of the photoelectric plethysmogram waveform data.

[0045] Also, the biological information calculation unit 422 can obtain heartbeat information as biological information (biologically generated information) from, for example, the interval of the QRS wave in the electrocardiogram waveform data (such as the electrocardiogram waveform data in FIG. 6) measured by the biological information measurement device 100 worn by the subject at rest.

[0046] Also, the biological information calculation unit 422 can obtain temperature information as biological information (biologically generated information) from the skin temperature information of the subject measured by, for example, the temperature sensor (such as a thermistor) of the biological information measurement device 100 worn by the subject.

[0047] In addition, the biological information calculation unit 422 can obtain walking speed information as biological information (biologically generated information) by using a known calculation method or the like alone or in combination (for example, averaging or weighting) from the waveform data of the acceleration data measured by the biological information measurement device 100 worn on the wrist of the subject. For example, the walking speed information can be obtained as biological information (biologically generated information) by integrating the acceleration data at predetermined time intervals.

[0048] In addition, the biological information calculation unit 422 can obtain stride information as biological information (biologically generated information) by using a known calculation method or the like alone or in combination (for example, averaging or weighting) from the waveform data of the acceleration data measured by the biological information measurement device 100 worn on the wrist of the subject. For example, when walking, the hands swing like pendulums. Therefore, based on the information of the above acceleration sensor (for example, the timing when the acceleration component in the traveling direction is the smallest or the timing when it switches to the reverse direction, or the timing when the acceleration component in the direction perpendicular to the traveling direction is the smallest or the timing when the up and down switches), the interval of one step can be determined. Furthermore, by using time information, the stride information can be obtained as biological information (biologically generated information). Alternatively, for example, when kicking the ground, the acceleration components in the kicking direction are combined. Therefore, it is also possible to determine the interval of one step based on the generation timing of the acceleration components in that direction.

[0049] In addition, the biological information calculation unit 422 can obtain motion information, which indicates how fast and at what angle the part (such as the wrist or ankle) where the biological information measurement device 100 is worn is moving, as biological information (biologically generated information) from the acceleration data and angular velocity data measured by the biological information measurement device 100 worn by the subject.

[0050] In addition, the biological information calculation unit 422 frequency-analyzes, for example, acceleration data measured by the biological information measurement device 100 that is routinely worn, and calculates, for example, based on predetermined conditions such as the correspondence between the high and low frequencies and the high and low activity frequencies, and what percentage of the day is occupied by activities above a predetermined frequency, to obtain activity amount information as biological information (biologically generated information).

[0051] In addition, the biological information calculation unit 422 can identify acceleration data during exercise including walking from, for example, acceleration data measured by the biological information measurement device 100 that is routinely worn, by known calculation methods or the like. Therefore, for example, momentum information can be obtained as biological information (biologically generated information) by calculating based on predetermined conditions using frequency analysis or the like. Also, by further using additional information such as angular velocity information, it is possible to obtain more accurate momentum information.

[0052] In addition, the biological information calculation unit 422 weights, for example, the above-mentioned activity amount information and momentum information derived from acceleration data measured by the biological information measurement device 100 that is routinely worn, with heart rate information that increases with exercise load, for example, to obtain exercise load amount information as biological information (biologically generated information). Also, for example, by taking into account vector information of acceleration data, state information such as walking environment (hills, stairs, etc.) and posture (standing position, sitting position, etc.) can also be identified, and the state information may be further used. Also, by further using additional information such as angular velocity information, it is possible to obtain more accurate exercise load amount information.

[0053] In addition, the biological information calculation unit 422 can obtain maximum oxygen uptake amount information as biological information (biologically generated information) by using, for example, the above-mentioned resting heart rate information and a known mathematical formula such as VO2max = 15×(220 - age)÷resting heart rate.

[0054] Further, based on teacher data associated by a known learning device or the like according to a correspondence relationship (which may include information indicating the degree or range of error, etc.) between, for example, biological measurement information, biological generation information generated based on the biological measurement information (such as heartbeat information and blood pressure information), and positive biological information (such as heartbeat information and blood pressure information based on known medical devices), a machine learning model may be created in advance, and the biological information calculation unit 422 may generate biological information by using the determination using the machine learning model as the above-described predetermined calculation (analysis).

[0055] The server device communication unit 412 is a communication interface for communicating with the terminal device 200 via a network 300 such as the Internet. It receives biological information such as electrocardiogram information and pulse wave information transmitted from the terminal device 200, and transmits a request signal for biological information such as electrocardiogram information and pulse wave information to the terminal device 200. Further, it transmits an abnormality notification to the terminal device 200.

[0056] The server device storage unit 413 stores biological information such as electrocardiogram information and pulse wave information received by the server device communication unit 412. It also stores blood pressure information calculated by the biological information calculation unit 422.

[0057] <Electrocardiogram waveform, photoelectric plethysmogram waveform, velocity pulse waveform, acceleration pulse waveform, blood pressure information calculation method> FIG. 6 shows an electrocardiogram waveform and a photoelectric plethysmogram waveform of a non-measured person measured by the biological information measurement device 100, and a velocity pulse waveform and an acceleration pulse waveform calculated by the server device 400. In order from the top in FIG. 6, there are an electrocardiogram waveform, a photoelectric plethysmogram waveform, a velocity pulse waveform, and an acceleration pulse waveform. The vertical axis indicates the intensity of each waveform, and the electrocardiogram waveform and the photoelectric plethysmogram waveform are represented in mV indicating potential. The horizontal axis indicates the passage of time, showing the passage of time from left to right.

[0058] The electrocardiogram waveform is a waveform that shows the periodic changes in the electrical signals that cause the beating of the human heart. The electrocardiogram waveform has the names of P wave, Q wave, R wave, S wave, and T wave assigned to the inflection points of its shape respectively, indicating one cycle of the heartbeat. The P wave represents atrial contraction, the Q wave, R wave, and S wave represent the state of ventricular contraction, and the T wave represents the start of ventricular relaxation.

[0059] The photoelectric plethysmogram waveform is a waveform that shows the changes in blood pressure and volume in the peripheral vascular system accompanying the beating of the human heart. The photoelectric plethysmogram waveform has the names of A wave, P wave, V wave, and D wave assigned to the inflection points of its shape respectively, indicating one cycle of the heartbeat. Using the A wave as the reference point when the arterial pulse wave occurs, the P wave represents the Percussion wave (shock wave) generated by left ventricular ejection, the V wave represents the Valley wave (wave due to repeated elevation) generated when the aortic valve closes, and the D wave represents the Dicrotic wave (repeated wave) which is the reflected vibration wave.

[0060] The velocity pulse waveform is the first-order time derivative of the photoelectric plethysmogram waveform. The acceleration pulse waveform is the first-order time derivative of the velocity pulse waveform, that is, the second-order time derivative of the photoelectric plethysmogram waveform. As shown in Figure 6, the acceleration pulse waveform has the names of a wave (positive wave at the beginning of contraction), b wave (negative wave at the beginning of contraction), c wave (re-rising wave in the middle of contraction), d wave (re-falling wave in the late stage of contraction), e wave (positive wave at the beginning of relaxation), and f wave (negative wave at the beginning of relaxation) assigned to each peak of its waveform. The ratio of the intensity of the b wave to the intensity of the a wave, and the ratio of the intensity of the f wave to the intensity of the e wave are parameters indicating the elasticity, that is, the stretchability of the blood vessels. The main components of blood vessels are endothelium, elastin, collagen, and smooth muscle. Each of these components has different properties, and collagen and elastin have a strong influence on the elasticity of blood vessels at maximum blood pressure and minimum blood pressure respectively. Therefore, the elasticity varying with blood pressure values can be indicated by the parameters of the ratio of the intensity of the b wave to the intensity of the a wave (b / a) and the ratio of the intensity of the f wave to the intensity of the e wave (f / e), and these values also vary due to the influence of age, gender, and environmental variables (such as temperature). Therefore, the values of (b / a) and (f / e) can be calculated as characteristic information of the acceleration pulse waveform.

[0061] As shown in FIG. 6, the time difference between the time Tr when the R wave occurs and the time Tp when the P wave occurs is the ventricular systolic pulse wave propagation time PTT_SYS. The time difference between the time Tt when the T wave occurs and the time Td when the D wave occurs is the ventricular diastolic pulse wave propagation time PTT_DIA. That is, from the time Tr of the R wave and the time Tt of the T wave in the electrocardiogram waveform, and the time Tp of the T wave and the time Td of the D wave in the photoelectric plethysmogram waveform, as shown in equations (1) and (2), the ventricular systolic pulse wave propagation time PTT_SYS and the ventricular diastolic pulse wave propagation time PTT_DIA can be calculated.

[0062] PTT_SYS = Tp - Tr ···(1)

[0063] PTT_DIA = Td - Tt ···(2)

[0064] The first electrode 121 to the fourth electrode 124 for measuring the electrocardiogram waveform and the optical sensor module 111 for measuring the photoelectric plethysmogram waveform are opposed to each other through the wrist, and by increasing the arrangement distance, the detection site of the electrocardiogram waveform and the measurement site of the photoelectric plethysmogram waveform are separated. Therefore, by generating a time lag at which each characteristic waveform occurs, the absolute calculation time of the ventricular systolic pulse wave propagation time PTT_SYS and the ventricular diastolic pulse wave propagation time PTT_DIA can be extended. Therefore, when obtaining the change information of the ventricular systolic pulse wave propagation time PTT_SYS and the ventricular diastolic pulse wave propagation time PTT_DIA, the accuracy of the change information can be improved.

[0065] Here, the blood pressure calculation formula will be described.

[0066] From the following formula (3) for the pulse wave propagation velocity (Moens - Korteweg formula), the relationship between the pulse wave propagation velocity and the longitudinal elastic modulus of the arterial wall is shown.

[0067] L / T_PTT = √(E·h / (2·r·ρ)) ···(3)

[0068] Each parameter in equation (3) is as follows: L is the distance between measurements, T_PTT is the pulse wave transit time, r is the inner diameter of the blood vessel, E is the longitudinal elastic modulus of the blood vessel, h is the thickness of the blood vessel, and ρ is the blood density.

[0069] It is known that the longitudinal elastic modulus and the blood pressure value are in a correlation relationship.

[0070] E = E0·exp(α·P) ···(4)

[0071] It can be expressed as follows. Here, P is the blood pressure value, α is a constant, and E0 is the initial value.

[0072] From equations (3) and (4),

[0073] P = (-2·ln(T_PTT) + ln(2·r·ρ·L 2 / (E0·h))) / α ···(5)

[0074] can be derived. ln represents the natural logarithm. At this time, since "r·ρ" is proportional to the blood volume at the measurement site, it can be represented by the high values (Vp, Vd) shown in the photoelectric plethysmogram waveform. Also, since "E0·h" is a value proportional to the elasticity of the blood vessel, it can be replaced using the parameters (b / a) and (f / e) indicating elasticity.

[0075] Therefore, the systolic blood pressure BP_SYS (Blood Pressure_Systolic) and the diastolic blood pressure BP_DIA (Blood Pressure_Diastolic) can be expressed by equations (6) and (7) shown below.

[0076] BP_SYS = A1·ln(PTT_SYS) + A2·ln(Vp) + A3·ln(b / a) + A4 ···(6)

[0077] BP_DIA = A5·ln(PTT_DIA) + A6·ln(Vd) + A7·ln(f / e) + A8 ···(7)

[0078] A1 to A8 are constants determined according to conditions. The systolic blood pressure BP_SYS that can be calculated by equation (6) can be obtained by adding the product of the natural logarithm of the ventricular systolic pulse wave propagation time PTT_SYS and the constant A1, the product of the natural logarithm of the P-wave intensity Vp and the constant A2, the product of the natural logarithm of (b / a) and the constant A3, and the constant A4. The diastolic blood pressure BP_SYS that can be calculated by equation (7) can be obtained by adding the product of the natural logarithm of the ventricular diastolic pulse wave propagation time PTT_DIA and the constant A5, the product of the natural logarithm of the D-wave intensity Vd and the constant A6, the product of the natural logarithm of (f / e) and the constant A7, and the constant A8. By obtaining each constant according to the characteristics of the device and the measurement subject, etc., it is possible to obtain the systolic blood pressure BP_SYS and the diastolic blood pressure BP_DIA. However, when checking the change states of the systolic blood pressure BP_SYS and the diastolic blood pressure BP_DIA, it is not necessary to determine all the constants, and it is possible to obtain the values as information regarding the systolic blood pressure BP_SYS and the diastolic blood pressure BP_DIA while substituting with provisional numerical values. The natural logarithm of the P-wave intensity Vp and the natural logarithm of the D-wave intensity Vd are terms considering the influence of blood density. Also, the natural logarithm of (b / a) and the natural logarithm of (f / e) are terms considering the influence of the longitudinal elastic modulus of the arterial wall. Therefore, depending on the measurement conditions, it may be possible to perform the calculation of the information regarding the systolic blood pressure BP_SYS and the information regarding the diastolic blood pressure BP_DIA by selecting one of the terms and making the other terms constant.

[0079] <Flow of the process> Next, the operation of the biological information measurement system 1 according to the first embodiment of the present invention will be described with reference to the flowchart illustrated in FIG. 7. The flowchart of FIG. 7 shows the related states of the operations of the biological information measurement device 100, the terminal device 200, and the server device 400.

[0080] In step S101, the biological information measurement device 100 loops until the measurement subject starts the measurement and performs an end operation until step S122.

[0081] In step S102, the electrocardiogram measurement control unit 141 detects an electrocardiogram from the first electrode 121 to the fourth electrode 124. Note that step S102 and step S104, and step S103 and step S105 are processed simultaneously in parallel by parallel processing.

[0082] In step S103, the electrocardiogram measurement control unit 141 generates an electrocardiogram waveform from the time change of the electrocardiogram detected in step S102.

[0083] In step S104, the pulse wave measurement control unit 142 controls the optical sensor module 111 to detect a pulse wave. Specifically, the light-emitting LED of the light-emitting unit 112 is caused to emit light and irradiate the wrist. The light-receiving unit 113 receives the light reflected from the wrist. The light-receiving unit 113 converts the received light into an electrical signal by a photodiode of the light-receiving unit 113 and transmits it to the pulse wave measurement control unit 142 as pulse wave information.

[0084] In step S105, the pulse wave measurement control unit 142 generates a photoelectric volume pulse waveform from the time change of the pulse wave information based on the pulse wave detected in step S104.

[0085] In step S106, the measurement device control unit 140 adds the detected time as the measurement time to the electrocardiogram waveform generated in step S103 and the photoelectric volume pulse waveform generated in step S105, and stores them in the measurement device storage unit 150 as electrocardiogram information and pulse wave information.

[0086] In step S107, the measurement device control unit 140 determines whether there is a measurement device data transmission trigger. When there is a measurement device data transmission trigger, that is, "yes" or "Y", it proceeds to step S107. When there is no such trigger, that is, "no" or "N", it proceeds to step S122. The measurement device data transmission trigger is an internal parameter within the biological information measurement device 100. When the biological information measurement device 100 constantly transmits electrocardiogram information and pulse wave information to the terminal device 200, this parameter is constantly set to "yes" or "1". When the biological information measurement device 100 periodically transmits electrocardiogram information and pulse wave information to the terminal device 200, the internal counter is used to set the measurement device data communication trigger to "1" at the set timing. Also, the measurement device data communication trigger may be set to "1" upon request from the terminal device 200.

[0087] In step S108, the measurement device control unit 140 transmits the electrocardiogram information and pulse wave information stored in the measurement device storage unit 150 to the terminal device 200.

[0088] In step S109, the terminal device control unit 211 stores the electrocardiogram information and pulse wave information received by the terminal device communication unit 213 in the terminal device storage unit 212.

[0089] In step S110, the terminal device control unit 211 determines whether there is a terminal device data transmission trigger. When there is a terminal device data transmission trigger, that is, "yes" or "Y", it proceeds to step S111. When there is no such trigger, that is, "no" or "N", it proceeds to step S121. The terminal device data transmission trigger is an internal parameter within the terminal device 200. When the terminal device 200 constantly transmits electrocardiogram information and pulse wave information to the server device 400, this parameter is constantly set to "yes" or "1". When the terminal device 200 periodically transmits electrocardiogram information and pulse wave information to the server device 400, the internal counter is used to set the terminal device data communication trigger to "1" at the set timing. Also, the terminal device data communication trigger may be set to "1" upon request from the server device 400.

[0090] In step S111, the terminal device control unit 211 transmits the electrocardiogram information and pulse wave information stored in the terminal device storage unit 212 to the server device 400.

[0091] In step S112, the server device control unit 411 stores the electrocardiogram information and pulse wave information received by the server device communication unit 412 in the server device storage unit 413.

[0092] In step S113, the server device control unit 411 calculates the pulse wave transit time from the electrocardiogram information and pulse wave information stored in the server device storage unit 413. The specific operation procedure will be described below. The pulse wave transit time calculation unit 421 extracts the waveform profiles in the electrocardiogram information and the pulse wave information that are close to the measurement timing. Next, the pulse wave transit time calculation unit 421 detects the R wave and T wave from the waveform profile in the electrocardiogram information, and stores the generated time information of the detected R wave and T wave as Tr and Tt. Similarly, the pulse wave transit time calculation unit 421 detects the P wave and D wave from the waveform profile in the photoelectric volume pulse waveform data, and stores the generated time information of the detected P wave and D wave as Tp and Td. At the same time, the intensity Vp of the P wave and the intensity Vd of the D wave are detected and stored. The pulse wave transit time calculation unit 421 calculates the difference between the generated time information Tr of the R wave and the generated time information Tp of the P wave as shown in FIG. 6, and calculates the ventricular systolic pulse wave transit time PTT_SYS. Similarly, the difference between the generated time information Tt of the T wave and the generated time information Td of the D wave is calculated to calculate the ventricular diastolic pulse wave transit time PTT_DIA.

[0093] In step S114, the server device control unit 411 calculates the second-order differential data from the photoelectric volume pulse waveform data stored in the server device storage unit 413. Specifically, as shown in FIG. 6, the first-order differential of the photoelectric volume pulse waveform data is performed, and the data obtained by the first-order differential is further differentiated to obtain the second-order differential data. The waveform obtained by differentiating the pulse wave twice is called the acceleration pulse waveform.

[0094] In step S115, the server device control unit 411 calculates the characteristic information of the acceleration pulse waveform from the second-order differential data obtained in step S114. The characteristic information of the acceleration pulse waveform is obtained by performing calculations from the intensities of the a-wave, b-wave, e-wave, and f-wave indicating the peaks of the acceleration pulse waveform described above.

[0095] In step S116, the server device control unit 411 calculates blood pressure information from the systolic pulse wave propagation time PTT_SYS obtained in step S113, the diastolic pulse wave propagation time PTT_DIA, and the characteristic information of the acceleration pulse waveform obtained in step S115. Calculations for blood pressure information related to the maximum blood pressure are performed from the systolic pulse wave propagation time PTT_SYS and the characteristic information of the acceleration pulse wave, and calculations for blood pressure information related to the minimum blood pressure are performed from the diastolic pulse wave propagation time PTT_DIA and the characteristic information of the acceleration pulse waveform. The calculations are performed using the aforementioned equations (6) and (7).

[0096] In step S117, the server device control unit 411 stores the blood pressure information calculated in step S116 in the server device storage unit 413.

[0097] In step S118, the server device control unit 411 analyzes the change state of the blood pressure information stored in the server device storage unit 413. If the change state is determined to be a deterioration in the health state of the subject being measured, the determination flag is set to "present" as abnormal. The determination flag is an internal parameter of the server device 400.

[0098] In step S119, the server device control unit 411 determines whether the determination flag is "present". If it is "present", the process proceeds to step S120; if it is "absent", the flow ends.

[0099] In step S120, the server device control unit 411 sends an abnormality notification to the terminal device 200 via the server device communication unit 412.

[0100] In step S121, the terminal device control unit 211 performs control to cause the terminal device display unit 214 to display a notification indicating that there is an abnormality in the health state based on the abnormality notification received by the terminal device communication unit 213. As a result, the terminal device 200 can notify the subject of an abnormality in the health state.

[0101] In step S122, the biological information measurement device 100 loops between step S101 until the power of the biological information measurement device 100 is turned off or an end operation of measurement is performed from the measurement device control unit 140.

[0102] <Description of the effect> As described above, the biological information measurement device 100 of the present invention can cope with subjects having various arm thicknesses, particularly by having the first arm portion 131 and the second arm portion 132, and can improve the detection accuracy of the electrocardiogram waveform.

[0103] As described above, some embodiments of the present invention have been described. However, these embodiments can be implemented in various other forms, and various omissions, replacements, and changes can be made without departing from the gist of the invention. These embodiments and their modifications are included in the scope and gist of the invention, and are also included in the invention described in the claims and the equivalent scope thereof.

Description of reference numerals

[0104] 1 ··· Biological information measurement system 100 ··· Biological information measurement device 200 ··· Terminal device 300 ··· Network 400 ··· Server device

Claims

1. A biological information measuring device having at least a main body part, wherein the main body part includes a first arm part and a second arm part that are curved from the upper part to the lower part of the main body part and extend left and right, the ends of the first arm part and the second arm part are separated from each other, and at least one of the ends of the first arm part and the second arm part is provided with an electrode for measuring biological information. A biological information measuring device characterized by the above.

2. At least one of the first arm part and the second arm part extends while being displaced outward in the front-rear direction at the lower part of the main body part. The biological information measuring device according to claim 1, characterized by the above.

3. At least a part of both ends of the first arm part and the second arm part extends to a length that overlaps with each other in the front-rear direction at the lower part of the main body part. The biological information measuring device according to claim 2, characterized by the above.

4. At least one of the ends of the first arm part and the second arm part is further curved from the lower side of the main body part toward the upper side of the main body part. The biological information measuring device according to any one of claims 1 to 3, characterized by the above.

5. The materials of the first arm part and the second arm part include a thermoplastic elastomer. The biological information measuring device according to any one of claims 1 to 4, characterized by the above.

6. The thermoplastic elastomer includes at least a polyether block amide. The biological information measuring device according to claim 5, characterized by the above.

7. The main body part does not have a display part. The biological information measuring device according to any one of claims 1 to 6, characterized by the above.

8. Two of the electrodes are provided on the same end side of the end sides of the first arm part and the second arm part. The biological information measuring device according to any one of claims 1 to 6, characterized by the above.

9. One of the electrodes is provided on each of the different end sides of the end sides of the first arm part and the second arm part. The biological information measuring device according to any one of claims 1 to 6, characterized by the above.

10. Two of the electrodes are provided on each of the different end sides of the end sides of the first arm part and the second arm part. The biological information measuring device according to any one of claims 1 to 6, characterized by the above.

11. An amplifier for amplifying the potential difference between two electrodes provided on the same end side is provided. The biological information measuring device according to any one of claims 1 to 10, characterized by the above.

12. The main body has a reference voltage terminal for obtaining a reference voltage at the upper part of the main body, and inputs the reference voltage to the amplifier. The biological information measuring device according to claim 11, characterized in that.

13. The reference voltage terminal is connected to a thermistor that measures the skin temperature of the person to be measured. The biological information measuring device according to claim 12, characterized in that.

14. The main body includes an optical sensor module that measures the pulse wave of the person to be measured. The biological information measuring device according to any one of claims 1 to 13, characterized in that.

15. The main body includes a communication unit that outputs the measured biological information to the outside. The biological information measuring device according to any one of claims 1 to 14, characterized in that.

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