Configuration method and device for detection items

Abstract

To provide a method and device for updating the configuration of detection items, a control terminal, and a sample analysis system.SOLUTION: A method comprises the steps of: obtaining a program mapping relation of a target detection item, the program mapping relation comprising a mapping relation between a plurality of target sample types and at least one target first experiment program; obtaining program configuration information of a target second experimental program, wherein the target second experimental program uniquely corresponds to the item type of the target detection item; and configuring the target detection item based on the program mapping relation and the program configuration information of the target second experimental program. According to the scheme, the convenience and efficiency of project configuration can be improved, and the sample registration efficiency and accuracy can be improved.SELECTED DRAWING: Figure 2

Description

[Technical Field]

[0001] The present application relates to the field of computer technology, and more particularly to a method and apparatus for setting detection items, a computer-readable storage medium, a control terminal, and a sample analysis system. [Background technology]

[0002] In vitro diagnostics refers to the detection and analysis of biological samples outside of a living organism using laboratory methods. Sample analysis usually involves a sample analysis device and a control terminal, where the control terminal is responsible for managing information and controlling the experiment, and the sample analysis device is responsible for performing the experimental operations.

[0003] The user needs to set the detection items in the control terminal, including setting the relevant experimental procedures for the detection items, and then input the sample information for the samples to be detected and register the items to be detected, and then use the control terminal to control the sample analysis instrument to perform the corresponding experimental operations according to the status of the samples to be detected and the items to be detected.

[0004] However, in the conventional detection item setting method, multiple detection items for the same type of detection item must be created and set on the control terminal, which makes the setting operation complicated and inefficient, and requires a lot of work when correcting the settings of subsequent items.In addition, confusion is likely to occur when the user registers samples, which delays the detection progress of the experiment and may even lead to incorrect registration and poor results. Summary of the Invention [Problem to be solved by the invention]

[0005] Based on this, it is necessary to provide a method and device for updating detection item settings, a control terminal, and a sample analysis system to address technical problems such as the complicated and inefficient operation of setting items proposed in the prior art, the large amount of work required for correction, and delays in experimental detection. [Means for solving the problem]

[0006] The method for setting detection items according to the present application is as follows: obtaining a procedure mapping relationship for the target detection items, the procedure mapping relationship including a mapping relationship between a plurality of target sample types and at least one target first experimental procedure; a step of acquiring procedure setting information of a target second experimental procedure, wherein the target second experimental procedure uniquely corresponds to the item type of the target detection item; and setting the target detection items based on the procedure mapping relationship and procedure setting information of the target second experimental procedure.

[0007] The detection item setting device according to the present application comprises: a mapping relationship acquisition module for acquiring a procedure mapping relationship of a target detection item, the procedure mapping relationship including a mapping relationship between a plurality of target sample types and at least one target first experimental procedure; a procedure setting acquisition module for acquiring procedure setting information of a target second experimental procedure, wherein the target second experimental procedure uniquely corresponds to the item type of the target detection item; and a detection item setting module for setting the target detection items based on the procedure mapping relationship and procedure setting information of the target second experimental procedure.

[0008] A computer-readable storage medium according to the present application stores a computer program that, when executed by a processor, causes the processor to perform the steps of the above-described method.

[0009] The control terminal according to the present application comprises a memory and a processor, and the memory stores a computer program that, when executed by the processor, causes the processor to perform the above method.

[0010] The sample analysis system according to the present application includes the above-described control terminal and sample analysis device, wherein the control terminal and the sample analysis device are communicatively connected, the control terminal is for acquiring and storing procedure mapping relationships of target detection items and procedure setting information of target second experimental procedures, the procedure mapping relationships including mapping relationships between a plurality of target sample types and at least one target first experimental procedure, and the target second experimental procedure uniquely corresponding to the item type of the target detection items; The control terminal is also used to classify experimental batches for the samples waiting to be detected based on the sample types and items waiting to be detected of the samples waiting to be detected, and to send experimental control commands to the sample analysis device for each of the experimental batches based on the procedure mapping relationship between the sample types and items waiting to be detected of the experimental batches and the procedure setting information of the second experimental procedure, wherein the samples waiting to be detected in the same experimental batch have the same sample types and items waiting to be detected, or the samples waiting to be detected in the same experimental batch correspond to the same first experimental procedure and have the same items waiting to be detected; The sample analysis equipment is for performing corresponding experimental operations on actual samples corresponding to samples to be detected in each of the experimental batches based on the experimental control instructions. [Effects of the Invention]

[0011] The above detection item setting method and device, computer-readable storage medium, control terminal, and sample analysis system obtain a mapping relationship between multiple sample types corresponding to a target detection item and at least one first experimental procedure, obtain procedure setting information for a second experimental procedure that uniquely corresponds to the item type of the target detection item, and set the target detection item based on the mapping relationship and procedure setting information. This allows a first experimental procedure corresponding to different sample types to be set for one detection item. When one detection item has multiple sample types, it is not necessary to create a separate detection item for each sample type; only one detection item is required. This simplifies the item setting and subsequent modification work and improves the convenience and efficiency of item setting. Furthermore, since only one detection item is displayed in the sample registration interface for detection items of the same type, confusion is effectively avoided when the user registers samples, and the registration efficiency and accuracy are improved. [Brief explanation of the drawings]

[0012] [Figure 1] FIG. 1 is a diagram illustrating an application environment of a detection item setting method according to an embodiment. [Figure 2] 1 is a flowchart of a method for setting detection items in one embodiment. [Figure 3] FIG. 10 is a diagram illustrating an operation for setting a first experimental procedure for a detection item in one embodiment. [Figure 4] FIG. 10 is an interface diagram of an item setting interface in one embodiment; [Figure 5] FIG. 10 is an interface diagram of an item setting interface in one embodiment; [Figure 6] FIG. 2 is a software interface diagram of the control software in one embodiment. [Figure 7] FIG. 1 is a diagram showing an example of the process of creating and setting up a nucleic acid extraction procedure. [Figure 8] FIG. 1 is a diagram showing an example of the process of creating and setting up a nucleic acid extraction procedure. [Figure 9] FIG. 10 is a diagram showing an example of a process for creating and setting nucleic acid detection items. [Figure 10] FIG. 10 is a diagram showing an example of a process for creating and setting nucleic acid detection items. [Figure 11] 1 is a block diagram showing the configuration of a detection item setting device according to an embodiment; [Figure 12] FIG. 2 is a block diagram showing the configuration of a control terminal in one embodiment. DETAILED DESCRIPTION OF THE INVENTION

[0013] With respect to technical terms used in this application, terms such as "comprise," "include," "have," "display," and any variations thereof are intended to cover a non-exclusive inclusion; for example, a process, method, system, product, or apparatus comprising a series of steps or units is not limited to the explicitly listed steps or units, but may further include steps or units not explicitly listed, or other steps or units inherent in the process, method, product, or apparatus. Terms such as "plurality" and "multiple types," and any variations thereof, mean at least two, unless otherwise clearly and specifically limited. Terms such as "first," "second," etc., are used to distinguish similar objects nomenclature, but the objects themselves are not limited by these terms, and should not be understood to indicate or imply relative importance, or to implicitly specify the number, particular order, or primary-subordinate relationship of the technical features indicated.

[0014] To make the objects and advantages of the present application clearer, the inventors have discovered that corresponding problems exist in the prior art and will now be described in detail.

[0015] In the field of in vitro diagnostics, during the process of sample analysis, it is necessary to set up detection items in a control terminal, including setting up related experimental procedures for the detection items. Usually, it is necessary to set up multiple types of experimental procedures for the detection items, including at least a first experimental procedure that is an experimental procedure related to the sample type of the detection item and a second experimental procedure that is an experimental procedure related to the item type of the detection item. For example, when setting up a nucleic acid detection item, it is necessary to set up a nucleic acid extraction procedure related to the sample type of the nucleic acid detection item and a nucleic acid amplification procedure related to the item type of the nucleic acid detection item.

[0016] However, the inventor discovered that in the conventional setting method, one detection item is created in the control terminal, and a first experimental procedure corresponding to one sample type is set for that detection item, and a second experimental procedure corresponding to such detection item is set; however, one type of detection item may correspond to multiple sample types, and multiple sample types may correspond to multiple first experimental procedures.Therefore, it is necessary to create multiple detection items in the control terminal and set a first experimental procedure corresponding to one of the sample types for each detection item, and also, since the item types of the multiple detection items are similar (i.e., they are the same type of detection items), a similar second experimental procedure is set for each detection item. For example, the novel coronavirus nucleic acid detection item corresponds to three sample types: throat swab, serum, and stool; these three sample types correspond to nucleic acid extraction procedures TQ1, TQ2, and TQ3, respectively; and a detection item such as novel coronavirus nucleic acid detection corresponds to nucleic acid amplification procedure KZ. Therefore, the control terminal creates three novel coronavirus nucleic acid detection items P1, P2, and P3, and sets nucleic acid extraction procedure TQ1 and nucleic acid amplification procedure KZ for novel coronavirus nucleic acid detection item P1, nucleic acid extraction procedure TQ2 and nucleic acid amplification procedure KZ for novel coronavirus nucleic acid detection item P2, and nucleic acid extraction procedure TQ3 and nucleic acid amplification procedure KZ for novel coronavirus nucleic acid detection item P3.

[0017] In this way, multiple detection items must be created and configured for the same type of detection item, and since there is a lot of common setting information among the multiple detection items, there are many duplicate operations in both item setting and subsequent modifications, which increases the amount of setting work, makes operations cumbersome, and reduces efficiency.

[0018] The inventors discovered that after completing the item setting, when registering a detection item for a sample to be detected, the control terminal displays a list of the item names of all detection items that have already been created in the sample registration interface, and the user identifies the detection item by its name and then selects and registers the corresponding detection item for each sample to be detected. However, if multiple detection items are created for one type of detection item, the multiple detection items are displayed simultaneously in the sample registration interface; for example, the above-mentioned novel coronavirus nucleic acid detection items P1, P2, and P3 are displayed simultaneously.

[0019] In this way, users are likely to forget the sample type corresponding to each displayed detection item, and are unable to clearly distinguish which detection item to select and register for the sample awaiting detection. For example, when selecting the detection item awaiting detection for a throat swab sample, the user may not be able to clearly distinguish which of P1, P2, and P3 is compatible with the throat swab sample type, which may reduce registration efficiency, delay the detection progress of the experiment, and may even cause registration errors and result in poor results.

[0020] To solve the above problems, the present application provides a detection item setting method and device, a computer-readable storage medium, a control terminal, and a sample analysis system for setting a first experimental procedure corresponding to different sample types for one detection item. Even if one type of detection item has multiple sample types, there is no need to create one detection item for each sample type, and only one detection item needs to be created. This simplifies the item setting and subsequent modification work and improves the convenience and efficiency of item setting. In addition, since only one detection item is displayed for the same type of detection item in the sample registration interface, confusion when the user registers samples is effectively avoided and the registration efficiency and accuracy are improved.

[0021] In order to facilitate understanding of the implementation of the technology of the present application, the application field and application environment of the present application will be described in detail.

[0022] The present application is applicable to the field of in vitro diagnostics, and a specific example of a specific field is nucleic acid detection. As shown in Figure 1, the application environment includes a control terminal 110 and a sample analysis device 120, control software is installed in the control terminal 110, and the control terminal 110 and the sample analysis device 120 are communicatively connected.

[0023] Specifically, the control software in the control terminal 110 first sets the detection items. That is, the control software acquires the item setting information for the detection items and then sets the detection items based on the related item setting information. The item setting information includes a mapping relationship between multiple sample types corresponding to the detection items and at least one first experimental procedure, and procedure setting information for a second experimental procedure that uniquely corresponds to the item type of the detection items. After the user places a sample in the sample analysis instrument 120, the user registers the sample in the control software. Specifically, the user inputs sample information for the sample to be detected and registers items to be detected for the sample to be detected, thereby obtaining sample registration information. Furthermore, the control software generates and transmits an experiment control command to the sample analysis instrument 120 based on the sample registration information for the sample to be detected and the item setting information for the registered items to be detected.

[0024] The sample analysis device 120 performs the corresponding experimental operation on the sample to be detected according to the experimental operation method instructed by the experimental control command, thereby obtaining the experimental detection data and sending it to the control software. In response, the control software analyzes and processes the experimental detection data to obtain the experimental detection results and display them to the user.

[0025] Here, the control terminal 110 may be, but is not limited to, various desktop computers, laptop computers, tablet computers, IoT (Internet of Things) devices, and smartphones. The sample analyzer 120 may be, but is not limited to, an in vitro diagnostic device, such as a PCR device.

[0026] A server (not shown) may be added to the application environment of the present application, and the control terminal 110 is communicatively connected to the sample analysis instrument 120 and the server, of which the server can be implemented as an independent server or a server cluster consisting of multiple servers. In this case, the control software in the control terminal 110 is responsible for providing a human-machine interaction interface for the user to perform related operations, and the corresponding data processing and storage tasks are implemented by the server. Specifically, for example, the user performs related operations in the control software interface, and the control software obtains item setting information for detection items and sample registration information for samples to be detected and sends this information to the server. The server further processes and stores this information, and when the experiment starts, the server generates an experiment control command based on the related information and sends it to the sample analysis instrument 120 via the control software in the control terminal 110.

[0027] The application environment of the present application may include only smart laboratory equipment, for example, a smart sample analysis equipment that integrates the functions of the control terminal 110 and the sample analysis equipment 120 in Figure 1. In this way, all process matters such as information management, experiment control, and execution of experiment operations can be realized by concentrating them in a single equipment.

[0028] To make the application environment of the present application more clearly understandable, the present application will be supplementarily described as an example, being applied to the subfield of nucleic acid detection in in vitro diagnostics.

[0029] The control terminal 110 in the application environment shown in FIG. 1 may be a PC host computer on which control software is installed, and the sample analyzer 120 may be a PCR multifunction machine.

[0030] Among these, the PCR multifunction machine, also known as a nucleic acid multifunction machine, is a type of PCR instrument, where PCR stands for polymerase chain reaction. A PCR multifunction machine includes a reagent preparation module, a nucleic acid extraction module, and a nucleic acid amplification module. The reagent preparation module completes the task of configuring the extraction plate and the amplification plate, i.e., configuring the extraction plate with extraction reagents and configuring the amplification plate with amplification reagents. The nucleic acid extraction module completes tasks such as sample addition, nucleic acid extraction, and nucleic acid transfer, i.e., taking a sample from a sample tube and adding it to the extraction plate, then performing nucleic acid extraction on the sample in the extraction plate and transferring the extracted nucleic acid to the amplification plate. The nucleic acid amplification module uses PCR technology to amplify the nucleic acid in the amplification plate to obtain PCR detection data.

[0031] If a sample to be detected requires a specific nucleic acid detection item, the control software of the PC host computer can be configured with the corresponding nucleic acid detection item. That is, the control software acquires the item setting information for the nucleic acid detection item and configures the nucleic acid detection item based on the relevant item setting information. The item setting information includes a mapping relationship between multiple sample types corresponding to the nucleic acid detection item and at least one nucleic acid extraction procedure, as well as procedure setting information for the nucleic acid amplification procedure corresponding to the nucleic acid detection item. After placing the sample in the sample chamber of the PCR multifunction printer, the user registers the sample in the control software. Specifically, the user inputs sample information for the sample to be detected and registers the nucleic acid detection item configured as described above as a target item for the sample to be detected, thereby obtaining sample registration information. Furthermore, the control software generates an experiment control command based on the sample registration information for the sample to be detected and the item setting information for the registered target item, and sends it to the PCR multifunction printer.

[0032] The PCR multifunction machine, according to the experimental operation mode instructed by the experimental control command, correspondingly completes experimental operations such as arranging the extraction plate and the amplification plate, adding the sample to the extraction plate, extracting nucleic acid, transferring nucleic acid, amplifying nucleic acid, etc., to obtain PCR detection data, and transmits the PCR detection data to the control software. Furthermore, the control software performs analysis processing on the PCR detection data to obtain the experimental detection results of the samples to be detected, which are displayed on the relevant interface.

[0033] The present invention will be described in more detail below with reference to the drawings and examples. Note that the following description will be given by taking the example of applying the method of the present invention to the control terminal in FIG. 1 as an example, but this is merely an illustrative description and does not limit the scope of the method to be executed by the control terminal alone.

[0034] In one embodiment, as shown in FIG. 2, a detection item setting method is provided, which includes the following steps S202 to S206.

[0035] In S202, the procedure mapping relationship of the target detection item is obtained.

[0036] A detection item is a medical item that performs a detection analysis on a biological sample to provide a detection result, and the biological sample is a collected body fluid or tissue used for detection analysis, such as blood, saliva, urine, skin, or other tissue. Depending on the sample analysis device, the detection item may be a nucleic acid detection item, specifically, a novel coronavirus nucleic acid detection item, an HPV nucleic acid detection item (Human Papilloma Virus), etc.

[0037] The target detection item is a detection item waiting to be set. The target detection item can be determined based on a user operation. For example, the user can trigger the control software to create a new detection item, and the control software can set the newly created detection item as the target detection item. Alternatively, the control software can display already created detection items, and the user can select one of them, and the control software can set the selected detection item as the target detection item.

[0038] In this embodiment, it is necessary to set an experimental procedure for the target detection item, and the set experimental procedure includes a first experimental procedure. The experimental procedure refers to the operational flow of the experimental stage related to the detection item, and the first experimental procedure refers to the experimental procedure related to the sample type of the detection item. For example, for a nucleic acid detection item, the first experimental procedure includes a nucleic acid extraction procedure, and the nucleic acid extraction procedure refers to the operational flow of the nucleic acid extraction stage in the nucleic acid detection item, which usually includes a liquid transfer step and an extraction step, and is related to the sample type of the nucleic acid detection item.

[0039] The procedure mapping relationship and the detection item have a one-to-one correspondence relationship, i.e., one detection item corresponds to a set of procedure mapping relationships, and the procedure mapping relationship includes a mapping relationship between multiple sample types of the detection items and at least one first experimental procedure. Correspondingly, the procedure mapping relationship of the target detection item includes a mapping relationship between multiple target sample types and at least one target first experimental procedure, where the target sample type is the sample type corresponding to the target detection item, and the target first experimental procedure is the first experimental procedure corresponding to the target detection item. From the perspective of data processing, the procedure mapping relationship can be realized using a commonly seen data structure, such as a mapping table.

[0040] In this embodiment, there are three cases of procedure mapping relationships for one target detection item.

[0041] In Case 1, the procedure mapping relationship includes a mapping relationship between multiple target sample types and multiple target first experimental procedures in one-to-one correspondence, and different target sample types may correspond to different target first experimental procedures. For example, for target detection item A1, the procedure mapping relationship includes a mapping relationship between five target sample types and five target first experimental procedures in one-to-one correspondence, i.e., five different target sample types correspond to five different target first experimental procedures.

[0042] In Case 2, the procedure mapping relationship includes mapping relationships between multiple target sample types and multiple target first experimental procedures, but these are not one-to-one correspondence relationships. Instead, the number of target sample types is greater than the number of target first experimental procedures, and each target first experimental procedure corresponds to one or more target sample types, with at least one of the target first experimental procedures simultaneously corresponding to multiple target sample types. That is, each of the multiple target sample types corresponds to a single target first experimental procedure, but some target sample types may correspond to similar target first experimental procedures. For example, for target detection item A2, the procedure mapping relationship includes mapping relationships between five target sample types and four target first experimental procedures, of which two target sample types correspond to the same target first experimental procedure and the other three target sample types correspond one-to-one to the other three first target experimental procedures. Or, for target detection item A3, the procedure mapping relationship includes mapping relationships between five target sample types and three target first experimental procedures, among which two target sample types correspond to the same target first experimental procedure, two other target sample types correspond to another one target first experimental procedure, and the remaining one target sample type corresponds to the remaining one target first experimental procedure.

[0043] In Case 3, the procedure mapping relationship may include mapping relationships between multiple target sample types and one target first experimental procedure, and all target sample types may correspond to the same target first experimental procedure. For example, for target detection item A4, the procedure mapping relationship may include mapping relationships between two target sample types and one target first experimental procedure, and both sample types correspond to the same target first experimental procedure.

[0044] In addition, there are multiple sources for the procedure mapping relationships of the target detection items, such as acquisition based on user input operations on the relevant interface of the control software, acquisition by code scanning, or transmission from another device to the control terminal. Correspondingly, a specific method for acquiring the procedure mapping relationships of the target detection items may involve first acquiring the mapping relationship between one target sample type and the corresponding first target experimental procedure, then acquiring the mapping relationship between the next target sample type and the corresponding first target experimental procedure, and so on, until the mapping relationships between all target sample types and all first target experimental procedures of the target detection items are acquired. Alternatively, a data packet including the mapping relationships between all target sample types and all first target experimental procedures of the target detection items, i.e., the procedure mapping relationships of the target detection items, may be directly acquired.

[0045] In S204, procedure setting information for the target second experimental procedure is acquired.

[0046] In this embodiment, in addition to setting a first experimental procedure for the target detection item, a second experimental procedure must also be set. The second experimental procedure refers to the experimental procedure related to the item type of the detection item, and different types of detection items can correspond to different second experimental procedures. For example, for a nucleic acid detection item, the second experimental procedure may include a nucleic acid amplification procedure. The novel coronavirus nucleic acid detection item and the HPV nucleic acid detection item may correspond to different nucleic acid amplification procedures, but the nucleic acid amplification procedure for the novel coronavirus nucleic acid detection item is the same regardless of the sample type, such as throat swab, serum, or stool.

[0047] Correspondingly, the target second experimental procedure refers to a second experimental procedure corresponding to the target detection item, and the target second experimental procedure uniquely corresponds to the item type of the target detection item. In this manner, in this embodiment, for one target detection item, one or more first experimental procedures can be set for the target detection item corresponding to multiple sample types of the target detection item, but since the item type of the target detection item is constant and unique, it can be understood that only one second experimental procedure can be set for the target detection item.

[0048] The procedure setting information is information for setting an experimental procedure. The content of the procedure setting information can be set according to detection needs. For example, the procedure setting information for a second experimental procedure usually includes experimental operation information for instructing the experimental operation method of the corresponding experimental stage. That is, the sample analysis instrument performs the experimental operation in the experimental stage according to the experimental operation method instructed by the corresponding experimental operation information. For example, for a nucleic acid detection item, the experimental operation information for a nucleic acid amplification procedure includes procedure segment distribution information and specific procedure segment setting information. The procedure segment distribution information includes, for example, the number of isothermal segments, circulation segments, and melting segments, and the order of each procedure segment. The specific procedure segment setting information includes, for example, the temperature, time, and circulation number of the isothermal segments. The control software can control the sample analysis instrument to perform the nucleic acid amplification process according to the experimental operation method instructed by the experimental operation information. In addition, the procedure setting information for the second experimental procedure may further include basic procedure information for describing the basic situation of the second experimental procedure, for example, a procedure identifier that is a unique identifier for the second experimental procedure; specifically, the control software may generate one procedure ID as a procedure identifier for the second experimental procedure, or the control software may obtain related information for the second experimental procedure (for example, the procedure name) and use that as the procedure identifier.

[0049] Similarly, there are multiple sources of procedure setting information for the second target experimental procedure, and for example, it may be obtained based on user input operations on the relevant interface of the control software, obtained by a code scanning method, or transmitted from another device to the control terminal.

[0050] In S206, the target detection items are set based on the procedure mapping relationship and the procedure setting information of the target second experimental procedure.

[0051] In this embodiment, in the process of setting the target detection items, the corresponding experimental procedures can be set for the target detection items based on the procedure mapping relationship of the target detection items and the procedure setting information of the target second experimental procedure; that is, the first experimental procedure can be set for the target detection items based on the procedure mapping relationship of the target detection items, and the second experimental procedure can be set for the target detection items based on the procedure setting information of the target second experimental procedure.

[0052] Note that setting a first experimental procedure for a target detection item may be performed in a similar manner, where a detection item has been created but the first experimental procedure has not yet been set, and the target detection item is subsequently set as the target detection item, and its procedure mapping relationship is acquired, and the first experimental procedure is then set for the target detection item so that it becomes something from nothing, based on the procedure mapping relationship. In another embodiment, a detection item may be created and a first experimental procedure has already been set, but if it is necessary to subsequently modify the first experimental procedure for that detection item, the target detection item may be set as the target detection item, and its procedure mapping relationship may be acquired, and the first experimental procedure may be updated and set for the target detection item based on the procedure mapping relationship. Setting a second experimental procedure for a target detection item is similar, and therefore will not be described here.

[0053] Specifically, the implementation method for setting the first experimental procedure and the second experimental procedure for the target detection item may store the procedure mapping relationship of the target detection item in association with the item identifier of the target detection item, and may store the procedure setting information of the target second experimental procedure in association with the item identifier of the target detection item, wherein the item identifier is a unique identifier of the target detection item, specifically, the control software may generate one item ID for the target detection item as the item identifier, or the control software may obtain related information of the target detection item (for example, the item name) as the item identifier.

[0054] For ease of understanding, the following description will be illustratively provided with reference to a specific embodiment. The control software pre-generates an item mapping table including fields such as an item identifier, a sample type, a procedure identifier for a first experimental procedure, and a procedure identifier for a second experimental procedure. For one target detection item, the control software acquires the item identifier, a procedure mapping relationship including type identifiers for multiple sample types of the target detection item and procedure identifiers for the first experimental procedure corresponding to each sample type, and procedure setting information for the second experimental procedure including the procedure identifier for the second experimental procedure. The acquired information, including the item identifier, the multiple type identifiers, and at least one procedure identifier for the first experimental procedure and the procedure identifier for the second experimental procedure, is stored in the item mapping table stored in the database in association with each other, thereby setting the first and second experimental procedures for the target detection item. Setting the first and second experimental procedures for other target detection items also involves saving the information for the target detection item in the item mapping table, and recording the associated setting information for all detection items created by the control software in the item mapping table according to the pre-defined fields.

[0055] In addition, when setting a target detection item, the relevant setting items can be determined according to the actual situation of the item, and in addition to setting the first and second experimental procedures for the target detection item, other setting items can be set for the target detection item. For example, when setting a nucleic acid detection item, in addition to setting an extraction procedure and an amplification procedure for the nucleic acid detection item, five setting items can be set for the nucleic acid detection item, including item basic information, reagent composition, detection target, result judgment, and quality control settings. In this way, in addition to obtaining the procedure mapping relationship of the target detection item and the procedure setting information of the target second experimental procedure, related setting information of other setting items can be obtained and used to set corresponding setting items for the target detection item.

[0056] The above detection item setting method obtains a mapping relationship between multiple sample types corresponding to a target detection item and at least one first experimental procedure, obtains procedure setting information for a second experimental procedure that uniquely corresponds to the item type of the target detection item, and sets the target detection item based on the mapping relationship and procedure setting information. This allows a first experimental procedure corresponding to different sample types to be set for one detection item. When one detection item has multiple sample types, it is not necessary to create a separate detection item for each sample type; only one detection item is required. This simplifies the item setting and subsequent modification work and improves the convenience and efficiency of item setting. Furthermore, since only one detection item is displayed for the same type of detection item in the sample registration interface, confusion is effectively avoided when the user registers samples, and the registration efficiency and accuracy are improved.

[0057] In one embodiment, step S202, which is a step of obtaining the procedure mapping relationship of the target detection items, may include the steps of: determining multiple target sample types based on a user's sample type input operation in the item setting interface; determining, for each target sample type, a first experimental procedure associated with the target sample type based on the procedure setting information of the first experimental procedure stored in advance; and determining a target first experimental procedure corresponding to the target sample type from the associated first experimental procedures based on the user's procedure selection operation in the item setting interface; and acquiring the procedure mapping relationship of the target detection items based on the determined multiple target sample types and the target first experimental procedures respectively corresponding to them.

[0058] The item setting interface is a software interaction interface for setting items. The item setting interface can be implemented in various ways, such as a single page or multiple pages. For example, the item setting interface can adopt a tab page. That is, the item setting interface includes multiple tab options corresponding to multiple setting items of the target detection item. Selecting one of the tab options displays a setting page for the corresponding setting item. Here, a tab option corresponding to a setting item called a first experimental procedure is included. Selecting this tab option displays a setting page for the first experimental procedure, allowing the user to perform related setting operations to set the first experimental procedure for the target detection item.

[0059] The sample type input operation is an operation in which the user inputs a sample type for a target detection item in the item setting interface, i.e., an operation in which the user inputs a target sample type. The sample type input operation may be performed, for example, by the user selecting a sample type from a drop-down box, or by the user entering information related to the target sample type in a text control.

[0060] The procedure selection operation is an operation in which a user inputs a first experimental procedure for a target detection item in the item setting interface, i.e., an operation in which a user selects a target first experimental procedure corresponding to a target sample type. The implementation manner of the procedure selection operation includes, for example, the user selecting from the first experimental procedures displayed in a drop-down box.

[0061] In this embodiment, for any target sample type entered by the user, a first experimental procedure associated with the target sample type is determined based on the procedure setting information of the first experimental procedure stored in advance. Therefore, before determining the first experimental procedure associated with the target sample type, it is necessary to perform procedure setting in advance for the first experimental procedure to be set for the target detection item. That is, it is necessary to complete the procedure setting task for the first target experimental procedure in advance, and obtain and store the procedure setting information of the first target experimental procedure. It can be understood that the procedure setting information of the first target experimental procedure includes at least the sample type associated with the first target experimental procedure. As mentioned above, the novel coronavirus nucleic acid detection item corresponds to three sample types: throat swab, serum, and feces. Before setting up the nucleic acid extraction procedure for the novel coronavirus nucleic acid detection item, it is necessary to first set up the procedure for the three nucleic acid extraction procedures, TQ1, TQ2, and TQ3, to obtain and store the procedure setting information for each of the three nucleic acid extraction procedures. The procedure setting information for TQ1, TQ2, and TQ3 is correspondingly recorded as being associated with the sample types of throat swab, serum, and feces.

[0062] For any target sample type, there may be only one or more first experimental procedures associated with it based on the procedure setting information of the first experimental procedures stored in advance. In actual applications, multiple target detection items are typically set in the control software one after another, so the database simultaneously stores procedure setting information for multiple first experimental procedures set for multiple detection items. If the procedure setting information for multiple first experimental procedures currently stored in the database for any target sample type is recorded as being associated with that target sample type, there will be multiple first experimental procedures associated with the confirmed target sample type, and the user will have to manually select one of them. However, if the database records only one procedure setting information for a first experimental procedure as being associated with that target sample type, there will only be one first experimental procedure associated with the confirmed target sample type, and the user only needs to confirm it.

[0063] The user must input multiple sample types for the target detection item and select a corresponding first experimental procedure for each sample type, and there are multiple specific implementation methods. For example, the user may input one sample type for the target detection item and select a corresponding first experimental procedure for that sample type, then input the next sample type and select a corresponding first experimental procedure for that sample type, and so on, until all sample types for the target detection item have been input and a corresponding first experimental procedure has been selected for each sample type. Alternatively, the user may input all sample types for the target detection item at once and select a corresponding first experimental procedure for each sample type.

[0064] The process of obtaining the procedure mapping relationship in this embodiment will be described below with reference to a specific example for clarity: Before setting a first experimental procedure for a target detection item, the control software pre-sets the procedure for the first experimental procedure that needs to be set for the target detection item, i.e., pre-sets the procedure for the target first experimental procedure, and obtains and stores procedure setting information for the target first experimental procedure, which includes a type identifier for the sample type associated with the first experimental procedure.

[0065] The control software then displays the item setting interface shown in FIG. 3 , which displays a tag option 301 corresponding to a setting item called "First Experimental Procedure." When the user selects this tag option 301, the control software displays a setting page for the First Experimental Procedure. The user inputs a target sample type by performing a sample type input operation on the setting page. Specifically, when the user clicks the Add New button 302 on the setting page, a setting pop-up box 303 pops up on the setting page. A sample pull-down box 3031 and a procedure pull-down box 3032 are displayed in the setting pop-up box. The user selects one of the sample types displayed in the sample pull-down box 3031. The selected sample type is the target sample type to be input, and the control software acquires its type identifier. Furthermore, the control software determines a first experimental procedure associated with the target sample type based on the type identifier and the procedure setting information of the first experimental procedure pre-stored in the database, and displays it in the procedure pull-down box 3032. The user selects one of the first experimental procedures displayed in the procedure pull-down box by performing a procedure selection operation. The control software then sets the selected first experimental procedure as the target first experimental procedure corresponding to the target sample type and obtains its procedure identifier. When the user then clicks the Save button 3033 in the setting pop-up box, the control software binds the type identifier of the target sample type with the procedure identifier of the target first experimental procedure to obtain a correspondence between them, and displays the entered target sample type and the corresponding target first experimental procedure on the setting page. For example, if the user selects a sample type called amniotic fluid and a first experimental procedure numbered 20221013151156, amniotic fluid and 20221013151156 are correspondingly displayed in FIG. 3 .The user inputs all target sample types and selects a corresponding target first experimental procedure for each target sample type, and the control software repeats the above operations until it correspondingly acquires type identifiers for multiple target sample types, procedure identifiers for at least one target first experimental procedure, and the correspondence between them, thereby obtaining the procedure mapping relationship of the target detection items.

[0066] In this embodiment, not only can the first experimental procedure be set for the target detection item by performing sample input operations and procedure selection operations in the item setting interface, but also the second experimental procedure and other setting items can be set for the target detection item by performing related setting operations in the item setting interface.The specific implementation method can adopt any applicable method in this field, so its description will be omitted here.

[0067] In summary, in this embodiment, the setting of target detection items is realized based on the user's operation on the item setting interface, allowing the user to flexibly input item setting information, providing high compatibility with item settings from third-party manufacturers and convenient operation.

[0068] In one embodiment, before the step of acquiring the procedure mapping relationship of the target detection item, i.e., before step S202, the method may further include a step of acquiring item basic information of the target detection item based on a user's basic information input operation in the item setting interface, and a step of creating the target detection item based on the item basic information in response to a user's operation to create a new item. Based on this, step S206, which is a step of setting the target detection item based on the procedure mapping relationship and the procedure setting information of the target second experimental procedure, may include a step of updating the target detection item based on the procedure mapping relationship and the procedure setting information of the second experimental procedure.

[0069] The basic information input operation is an operation in which a user inputs basic item information for a target detection item in the item setting interface, where the basic item information describes the basic status of the target detection item, such as the item name, item type, etc. The basic information input operation can be performed in such a way that the user enters the basic item information in a text control, or selects it from a pull-down box, or a combination of these two ways.

[0070] The new item creation operation is an operation that triggers the creation of a target detection item, that is, when the user performs the new item creation operation, it triggers the control software to create a target detection item. The new item creation operation can be performed, for example, by the user clicking the save item button in the item setting interface, or by performing a pre-defined gesture operation in the item setting interface, specifically, by the user drawing a pre-defined trajectory in the item setting interface using a touch or mouse.

[0071] Specifically, first, the user performs a basic information input operation in the item setting interface, and the control software acquires the item basic information of the target detection item. Then, the user performs a new item creation operation, and the control software creates the target detection item based on the item basic information in response to the operation. Although the control software has created one target detection item, it has only set the item basic information for the target detection item and has not set other setting items such as the first and second experimental procedures. Then, the user performs a sample type input operation and a procedure selection operation for the target detection item, and the control software acquires the procedure mapping relationship of the target detection item and sets the first experimental procedure for the target detection item based on the procedure mapping relationship, and acquires procedure setting information for the second target experimental procedure and sets the second experimental procedure for the target detection item based on the procedure setting information, thereby updating the related settings of the target detection item.

[0072] To sum up, in this embodiment, the user only needs to input the basic item information of the target detection item to trigger the control software to create the target detection item, and then can select the timing according to the actual situation to further set other setting items such as experimental procedures for the target detection item. Since the user does not need to input the related setting information for all setting items at once, the item setting is highly flexible and can better meet the needs of users in different scenarios.

[0073] In other embodiments, the creation of a target detection item may be prohibited unless the user inputs the relevant setting information for all setting items of the target detection item. In this method, the user needs to input a lot of information at once, which increases the operating pressure, but it can prevent the item setting contents from being omitted and causing adverse effects. For example, if it is discovered that the item setting contents have been omitted after the experimental detection has begun, it will be necessary to make corrections, which may have a significant impact on the experimental process.

[0074] In one embodiment, step S202, which is a step of obtaining a procedure mapping relationship of a target detection item, may include a step of analyzing item graphic code information obtained by scanning with a code scanning device to obtain a procedure mapping relationship of the target detection item.

[0075] The item graphic code is a graphic code for setting the target detection item, and there is a one-to-one correspondence between the item graphic code and the target detection item, i.e., one target detection item corresponds to one item graphic code. Specifically, the item graphic code only needs to store related item setting information, and may be a two-dimensional code or a barcode. In practical applications, the item graphic code is usually printed on the kit.

[0076] The code scanning device is a device for scanning item graphic codes, and may be a code scanning gun, a tablet, a mobile phone, or any other applicable device, and is communicatively connected to a control terminal via wire or wirelessly.

[0077] In this embodiment, a user scans an item graphic code using a code scanning device, and the control software obtains the item graphic code information and analyzes the item graphic code information according to a preset decoding procedure to obtain the procedure mapping relationship of the target detection item. Specifically, the control software analyzes the item graphic code information to obtain type identifiers of multiple target sample types, procedure identifiers of at least one target first experimental procedure, and the correspondence relationship between them.

[0078] To sum up, in this embodiment, the user does not need to manually input a large amount of information, and the procedure mapping relationship of the target detection item can be obtained by code scanning, so the input of item setting information can be completed efficiently and easily. Furthermore, since the item setting information is pre-packaged in a graphic code, the information content will not be disclosed to the outside, which is advantageous for information confidentiality in self-research and production scenarios.

[0079] In one embodiment, before the step of setting the target detection item based on the procedure mapping relationship and the procedure setting information of the second target experimental procedure, i.e., before step S206, the method may further include a step of analyzing the item graphic code to obtain item basic information of the target detection item. Based on this, step S204, which is a step of obtaining the procedure setting information of the second target experimental procedure, may include a step of analyzing the item graphic code to obtain the procedure setting information of the second target experimental procedure. Then, step S206, which is a step of setting the target detection item based on the procedure mapping relationship and the procedure setting information of the second target experimental procedure, may include a step of creating and setting the target detection item based on the item basic information, the procedure mapping relationship, and the procedure setting information of the second target experimental procedure.

[0080] In this embodiment, the control software analyzes the item graphic code information according to a preset decoding procedure, and then obtains the procedure mapping relationship of the target detection item as well as the item basic information of the target detection item and the procedure setting information of the second experimental procedure, and further creates the target detection item and sets the item basic information, the first experimental procedure, and the second experimental procedure for the target detection item. By scanning the item graphic code and obtaining more item setting information of the target detection item, item setting can be performed efficiently and easily.

[0081] In another embodiment, the relevant setting information of all the setting items of the target detection item can be obtained by scanning the item graphic code, and then the target detection item can be created and all the setting items can be configured for the target detection item. For example, as described above, seven setting items, including item basic information, reagent composition, detection target, result judgment, nucleic acid extraction procedure, nucleic acid amplification procedure, and quality control settings, need to be configured for the nucleic acid detection item. The item graphic code contains the relevant setting information of the seven setting items. The user can use a code scanning device to scan the item graphic code, and the control terminal can analyze the item graphic code information according to a preset decoding procedure to obtain the setting information corresponding to each of the seven setting items, thereby efficiently completing the task of creating and configuring the corresponding nucleic acid detection item.

[0082] In one embodiment, the method for setting detection items according to the present application includes: displaying an item setting interface, the item setting interface including a mode selection control, an item list area, and an item editing area, the mode selection control including an open option and a closed option; If the mode selection control corresponds to an open option, displaying open detection items in the item list area, the open detection items including detection items created based on a user's operation on the item setting interface; a step of displaying a setting page corresponding to the selected open-type detection item in an item editing area based on a selection operation for the displayed open-type detection item, the setting page corresponding to the open-type detection item including a setting page for a first experimental procedure and a setting page for a second experimental procedure; if the mode selection control corresponds to a closed option, displaying closed-type detection items in the item list area, the closed-type detection items including detection items created by the item graphic code; The method may further include a step of displaying a setting page corresponding to the selected closed-type detection item in the item editing area based on a selection operation for the displayed closed-type detection item, wherein the setting page corresponding to the closed-type detection item does not include a setting page for the first experimental procedure and a setting page for the second experimental procedure.

[0083] Here, the mode selection control is for switching between open options and closed options, and the user can select the open option or the closed option according to actual needs. In specific implementation, a pull-down box or any other applicable display control can be adopted. The item list area is an area for displaying previously created detection items, and the item editing area is an area for displaying a setting page corresponding to the detection item. Specifically, when one of the detection items displayed in the item list area is selected, the setting page corresponding to the selected detection item is correspondingly displayed in the item editing area. In the item setting interface, the arrangement positions and sizes of the mode selection control, item list area, and item editing area can all be implemented in various ways and can be flexibly designed according to actual needs. For example, the item list area and item editing area are respectively located on the left and right sides of the item setting interface, and the mode selection control is located above the item list area.

[0084] Specifically, when the mode selection control corresponds to a closed-type option, all the closed-type detection items that have already been created are displayed in the item list area, among which the closed-type detection items include detection items created by item graphic codes. As a specific display method, for example, each closed-type detection item may be listed in list form, so that the user can grasp the overall situation of the closed-type detection items through the item list area, for example, the total number of items, and can further view and edit the related content by selecting a specific closed-type detection item in the item list area.

[0085] When a user selects one of the closed-type detection items displayed in the item list area, a setting page corresponding to the selected closed-type detection item is displayed in the item editing area. Specifically, the setting page corresponds to the public setting item of the closed-type detection item, and the setting page and the public setting item may correspond one-to-one. The public setting item of the closed-type detection item can be preset according to actual needs, and may be set to one or more. However, considering information confidentiality, the public setting items set for the closed-type detection item are usually relatively few. For example, the public setting items are preset to include only a setting item called "item basic information." Therefore, for the closed-type detection item, the setting pages of other setting items are not displayed in the item editing area, and only the setting page of the item basic information is displayed. Note that in this embodiment, the public setting items of the closed-type detection item are required not to include the two setting items called "first experimental procedure" and "second experimental procedure." That is, for the closed-type detection item, the setting page of the first experimental procedure and the setting page of the second experimental procedure are not displayed in the item editing area.

[0086] The specific display content on the setting page usually includes the public setting information of the corresponding public setting item, i.e., the setting information disclosed to the outside, and the public setting information may be set in advance according to actual needs, and specifically may include edit permission information and edit prohibition information, and on the setting page, edit prohibition information is in a state where it cannot be edited, and users are not allowed to edit it but are only allowed to view it, and edit permission information is in a state where it can be edited, and both viewing and editing are possible.

[0087] To explain this by way of example, the sample analysis device is a PCR multifunction machine, and correspondingly, a nucleic acid detection item is set in the control software. The public setting items for the closed detection item are pre-set to include only two setting items: item basic information and quality control settings, and do not include the five setting items of reagent composition, detection target, result judgment, nucleic acid extraction procedure, and nucleic acid amplification procedure. The public setting information for the public setting item, item basic information, includes item abbreviation, item name, item type, item number, LIS channel number, number of repetitions, result unit, and display order. The public setting information for the quality control settings is pre-set to include the quality control type required for each batch of experiments, of which the LIS channel number, number of repetitions, result unit, display order, and quality control type are pre-set as editable information, and the rest are pre-set as non-editable information.

[0088] There are several methods for displaying setting pages in the item editing area. For example, a Tabs tab page can be used, in which tab options corresponding to each public setting item are displayed in the item editing area. When one of the tab options is selected, the setting page of the corresponding public setting item is displayed in the item editing area. If another tab option is then selected, the setting page of the other public setting item is switched to and displayed in the item editing area. As described above, for a nucleic acid detection item, when the closed option is selected in the mode selection control 401, the item setting interface displays all closed nucleic acid detection items that have already been created in the item list area 402, as shown in Figure 4. When the user selects the closed nucleic acid detection item "(Closed) COVID" from among these, the item editing area 403 displays tab options 4031 and 4032 corresponding to two public setting items, namely, item basic information and quality control settings. Furthermore, since the control software selected tab option 4031 corresponding to item basic information by default, the item editing area displays setting page 4033 for the item basic information of the closed nucleic acid detection item by default. If the user then changes to and selects tab option 4032 corresponding to quality control settings, the item editing area switches to and displays the setting page (not shown) for the quality control settings of the closed nucleic acid detection item.

[0089] When the mode selection control corresponds to the open option, the item list area displays all open detection items that have already been created, among which the open detection items include detection items created based on the user's operation in the item setting interface. Similarly, a specific display method may be, for example, listing each open detection item in list form, so that the user can grasp the overall status of the open detection items through the item list area, and can create a new open detection item in the item setting interface and set related content, or can directly select a specific open detection item from the item list area to further view and set related content.

[0090] Similar to the closed-type detection items, when a user selects one of the open-type detection items displayed in the item list area, a setting page corresponding to the selected open-type detection item is displayed in the item editing area. Specifically, the setting page corresponds to the public setting items of the open-type detection item, and one setting page may correspond to one public setting item. The public setting items of the open-type detection item may be pre-set according to actual needs. Typically, multiple setting items are set, and the user is required to fully input the related setting information for the related setting items to ensure that the experimental detection is performed normally. In this embodiment, the public setting items of the open-type detection item are required to include two setting items, namely, a first experimental procedure and a second experimental procedure. That is, for an open-type detection item, a setting page for the first experimental procedure and a setting page for the second experimental procedure are displayed in the item editing area. Similarly, the setting page specifically displays the public setting information of the corresponding public setting item, which may be pre-set according to actual needs. Specifically, it includes editing permission information and editing prohibition information, but this description is omitted here.

[0091] Similarly, taking a nucleic acid detection item as an example, the public setting items for an open detection item include seven setting items: item basic information, reagent composition, detection target, result judgment, nucleic acid extraction procedure, nucleic acid amplification procedure, and quality control settings. The public setting information for the item basic information is pre-set to include item abbreviation, item name, item type, item number, LIS channel number, number of repetitions, result unit, display order, nucleic acid addition amount, and exogenous internal standard addition amount. Except for the item type, which is set as non-editable information, the rest are all set as editable information. The public setting information for the nucleic acid extraction procedure includes sample type and nucleic acid extraction procedure, both of which are set as editable information. The public setting information for the nucleic acid amplification procedure includes procedure segment distribution information and specific setting information for the procedure segments, both of which are set as editable information. The public setting information for other setting items can also be set according to actual needs, but since this is not the focus of this application, its description will be omitted here.

[0092] 5, when the open option is selected in the mode selection control 501, all open-type nucleic acid detection items that have already been created are displayed in the item list area 502. When the user selects the open-type nucleic acid detection item "(Open) COVID," the item editing area 503 displays tab options corresponding to seven setting items: item basic information, reagent composition, detection target, result judgment, nucleic acid extraction procedure, nucleic acid amplification procedure, and quality control settings. The control software selects tab option 5031 corresponding to the item basic information by default, and thus displays setting page 5032 for the item basic information of the open-type nucleic acid detection item by default in the item editing area. When the user then changes to and selects tab option 5033 corresponding to the nucleic acid extraction procedure, the item editing area switches to and displays setting page 5034 for the nucleic acid extraction procedure of the open-type nucleic acid detection item.

[0093] In summary, this embodiment simultaneously supports two types of information input modes: closed type and open type. In the open type, target detection items are created and set based on user operations in the item setting interface, and the user can input and view related item setting information in the item setting interface. In the closed type, target detection items are created and set using code scanning, and the user can further view and edit a small amount of item setting information in the item setting interface. This can flexibly meet the item setting needs of different scenarios, and can efficiently, easily, and safely set items for self-research and production scenarios, and can also be compatible and flexibly input item setting information for third-party manufacturers.

[0094] In one embodiment, the detection item setting method of the present application may include at least one of a first term for acquiring and storing procedure setting information for a first target experimental procedure based on a user's procedure information input operation on a procedure setting interface, and a second term for analyzing procedure graphic code information to acquire and store procedure setting information for the first target experimental procedure.

[0095] As described above, it is necessary to perform procedure setting for the first target experimental procedure itself and obtain and store procedure setting information for the first target experimental procedure. Similar to the setting of the target detection item, the first target experimental procedure may be created and set based on user operations on the procedure setting interface, or may be created and set using a code scanning method, or these two methods may be supported simultaneously.

[0096] In one embodiment, procedure setting information for a target first experimental procedure is acquired and stored based on a user's procedure information input operation on a procedure setting interface.

[0097] The procedure setting interface is a software interaction interface for setting the first experimental procedure. Like the item setting interface, the procedure setting interface can be implemented in a single-page or multi-page format, specifically, a tab page. The procedure information input operation is an operation for inputting procedure setting information for the target first experimental procedure in the procedure setting interface. Specifically, this can be implemented by, for example, the user entering procedure setting information in a text control, the user selecting from a drop-down box, or a combination of these two methods. The procedure setting information for the first experimental procedure includes basic procedure information and experimental step information. The basic procedure information describes the basic conditions of the first experimental procedure, including at least the sample type associated with the first experimental procedure and usually further including the procedure name. The experimental step information indicates the experimental operation method for the corresponding experimental stage. For example, for a nucleic acid detection item, the experimental operation information for the nucleic acid extraction procedure includes liquid transfer step information and extraction step information.

[0098] Taking the procedure setting interface as an example, a Tabs tab page will be described. When setting the procedure for the first experimental procedure, the procedure setting interface includes multiple tab options corresponding to multiple setting items of the first experimental procedure, respectively. Selecting one of the tab options will display a setting page for the corresponding setting item, including tab options corresponding to setting items such as basic procedure information and experimental steps. Selecting a tab option corresponding to the basic procedure information will correspondingly display a setting page for the basic procedure information. Selecting a tab option corresponding to an experimental step will correspondingly display a setting page for the experimental step, allowing the user to input related setting information to realize the procedure setting for the first experimental procedure itself.

[0099] In this embodiment, the procedure setting of the target first experimental procedure is realized based on the user's operation on the procedure setting interface, which allows the user to flexibly input procedure setting information, has high compatibility with procedure settings from third-party manufacturers, and is easy to operate.

[0100] In another embodiment, the procedure setting information of the target first experimental procedure is obtained and stored by analyzing the procedure graphic code information.

[0101] Among them, the procedure graphic code is a graphic code for setting the first target experimental procedure, and like the item graphic code, the procedure graphic code and the first target experimental procedure have a one-to-one correspondence relationship, and specifically, may be a two-dimensional code or a barcode, etc. Similarly, in this embodiment, the procedure setting information of the first target experimental procedure also includes basic procedure information and experimental step information, and the code scanning device is the same as described above, so its description will be omitted.

[0102] Specifically, when a user scans a procedure graphic code using a code scanning device, the control terminal obtains the procedure graphic code information, and then analyzes the procedure graphic code information according to a preset decoding procedure to obtain and store the procedure setting information of the target first experimental procedure. This method eliminates the need for the user to manually enter a large amount of information, and allows the user to efficiently and easily complete the input of procedure setting information. Furthermore, since the procedure setting information is pre-packaged in the graphic code, the information content will not be disclosed to the outside, which is advantageous for information confidentiality.

[0103] In another embodiment, the control software can support the above two methods simultaneously. The user can either input procedure information in the procedure setting interface or scan the procedure graphic code using a code scanning device. When the control software detects the procedure information input operation, it obtains the procedure setting information of the first target experimental procedure based on the operation. When the control software obtains the procedure graphic code information, it analyzes it to obtain the procedure setting information of the first target experimental procedure, so as to flexibly meet the needs of different scenarios.

[0104] In one embodiment, the method for setting detection items according to the present application may further include the steps of: displaying a sample registration interface in which samples awaiting detection and candidate detection items are displayed; determining samples awaiting registration from the samples awaiting detection based on a sample selection operation in the sample registration interface; determining items awaiting detection from the candidate detection items based on an item selection operation in the sample registration interface; and registering the items awaiting detection for the samples awaiting registration in response to a registration trigger operation.

[0105] The sample registration interface is a software interaction page for realizing the sample registration function. During the sample analysis process, after creating and setting the target detection items, it is necessary to perform sample registration, including registering the items to be detected for the samples to be detected. In this embodiment, sample registration can be realized through the sample registration interface.

[0106] Specifically, samples to be detected are displayed in the sample registration interface, and the samples to be detected correspond one-to-one to target entity samples placed in the sample analysis device, where the target entity samples are entity samples placed in the sample analysis device that require experimental detection. For example, a laboratory needs to perform experimental detection on N entity samples. A user places the N entity samples in the sample analysis device, and the N entity samples may be target entity samples. The control software displays N samples to be detected in the sample registration interface, each corresponding one-to-one to the N target entity samples, so that the user can perform sample registration operations. The samples to be detected may also be interface elements. For example, the sample registration interface may display sample icons, each representing a sample to be detected, or the sample registration interface may display a sample list, each entry in the sample list representing a sample to be detected.

[0107] The sample registration interface further displays candidate detection items, which include all detection items already created in the control software, including the closed-type detection items and open-type detection items described above. In other words, any detection item already created in the control software is displayed in the sample registration interface for the user to use when registering a sample.

[0108] The sample selection operation is an operation of selecting a sample to be registered from the samples to be detected displayed in the sample registration interface, and the samples to be registered are samples to be detected that currently require sample registration. Specifically, this may be a single selection operation in which the user selects only one sample to be detected at a time and registers it alone, or a multiple selection operation in which the user selects multiple samples to be detected at a time and registers them all at once. In a specific implementation, the sample selection operation may be a click operation on the sample to be detected, a check operation on a checkbox set for each sample to be detected, or a frame selection operation on the samples to be detected, etc.

[0109] The item selection operation is an operation of selecting an item to be detected for a sample to be registered. Similarly, it may be a single selection operation in which the user selects and registers only one item to be detected for a sample to be registered at a time, or a multiple selection operation in which the user selects and registers multiple items to be detected for a sample to be registered at a time. Similarly, specifically, any applicable operation method such as clicking, checking, or frame selection may be adopted.

[0110] In this embodiment, the control software displays a sample registration interface that lists samples to be detected and candidate detection items. The user performs a sample selection operation on the interface to select one or more samples to be detected as samples to be registered, and performs an item selection operation to select one or more detection items from the candidate detection items as detection items. After the user performs a registration trigger operation, the control software registers the detection items for the samples to be registered. The user can also repeat the above operation according to actual needs to register multiple samples to be detected, and then perform experimental detection for the samples to be detected whose registration has been completed.

[0111] In addition, sample registration may include not only registering items to be detected for samples to be detected, but also entering other registration items, such as sample information for samples to be detected. The sample information may be specifically set according to actual needs, such as the sample number and sample type. There may be multiple ways to trigger the display of the sample registration interface, such as the user clicking a sample registration button or the user performing a preset gesture operation. The sample registration interface may employ any applicable page design, as long as it can realize the sample registration function.

[0112] In one embodiment, the detection item setting method of the present application may further include the steps of: in response to an experiment start operation, dividing an experimental batch into samples awaiting detection based on the sample type and items awaiting detection of the samples awaiting detection; and, for each experimental batch, controlling a sample analysis device to perform a corresponding experimental operation on a target entity sample corresponding to the samples awaiting detection in the experimental batch based on the sample type of the experimental batch and the procedure mapping relationship of the items awaiting detection of the experimental batch and the procedure setting information of the second experimental procedure.

[0113] The experiment start operation is an operation that triggers the experiment detection. In the sample analysis process, the experiment detection can be started after completing the sample registration. For example, the user can click the experiment start button to trigger the sample analysis device to start performing the corresponding experiment operation.

[0114] In this embodiment, after detecting the experiment start operation, the control software may classify the experimental batches for the samples to be detected, specifically, based on the sample types of the samples to be detected and the registered items to be detected, then perform corresponding experimental detection for each experimental batch, and control the sample analyzer to perform corresponding experimental operations on the target entity samples corresponding to the samples to be detected in the experimental batch based on the procedure mapping relationship between the sample types of the experimental batch and the items to be detected in the experimental batch and the procedure setting information of the second experimental procedure, specifically, determine a first experimental procedure corresponding to the experimental batch based on the sample types of the experimental batch and the procedure mapping relationship between the items to be detected in the experimental batch, obtain the procedure setting information for the first experimental procedure from the database, and obtain the procedure setting information for the second experimental procedure for the items to be detected in the experimental batch, and further control the sample analyzer to perform corresponding experimental operations on the target entity samples corresponding to the samples to be detected in the experimental batch based on the procedure setting information for the first experimental procedure and the procedure setting information for the second experimental procedure.

[0115] Regarding the specific manner of dividing the experimental batches, in one embodiment, samples to be detected that are divided into the same experimental batch may have the same sample type and item to be detected.

[0116] In another embodiment, samples to be detected that are grouped into the same experimental batch may correspond to the same first experimental procedure and have the same item to be detected. That is, samples to be detected in the same experimental batch may be of different sample types as long as each sample type corresponds to the same first experimental procedure. For example, if there are five samples to be detected, all of which have the same item to be detected, but the five samples to be detected are of three different sample types, with two of the samples to be detected, S1 and S2, being of the first sample type, two of the samples to be detected, S3 and S4, being of the second sample type, and sample to be detected, S5, being of the third sample type, and in the procedure mapping relationship, the first and second sample types correspond to the same first experimental procedure, and the third sample type corresponds to a different, different first experimental procedure, then, when grouping the experimental batches, samples to be detected S1-S4 may be grouped into the same experimental batch, and sample to be detected S5 may be grouped into a different experimental batch.

[0117] In response to this, the inventor discovered that in the prior art, multiple detection items for the same type of detection item must be created and configured, and the control terminal must control the sample analysis device to perform the experimental detection. When experimental detection is performed on a batch-by-batch basis, only one detection item is configured for each experimental batch. Even if the same type of detection item is performed on multiple samples to be detected, different detection items are registered for different sample types, and the samples are further divided into different experimental batches for detection. For example, as mentioned above, if a novel coronavirus nucleic acid detection item is performed on each of 10 samples to be detected, three of which are throat swabs, three are serum, and four are feces, three novel coronavirus nucleic acid detection items P1, P2, and P3 are registered and further divided into three experimental batches. This increases the number of experimental batches, further extending the time required for experimental detection and wasting resources such as experimental reagents and consumables. However, in the present application, for one detection item, a first experimental procedure corresponding to different sample types is set, and samples awaiting detection in the same experimental batch correspond to the same first experimental procedure and have the same items awaiting detection, so that more samples awaiting detection can be divided into the same experimental batch for experimental detection, thereby reducing the number of experimental batches, saving experimental time and reducing waste of experimental resources.

[0118] In the sample analysis process, the control software integrates various information to control the sample analysis equipment to perform the experiment. The above only describes the first and second experimental procedures for the items waiting for detection. However, other procedures such as quality control and reagents are not the focus of this application and can be realized by any applicable method in this field, so the description thereof will be omitted here.

[0119] In the following, the main contents of the present application will be explained with reference to one specific application example for clear and intuitive understanding.

[0120] In this example, applied to the field of nucleic acid detection, novel coronavirus nucleic acid detection was performed on 10 samples, of which three were throat swabs, three were serum, and four were feces. These three sample types correspond to nucleic acid extraction procedures TQ1, TQ2, and TQ3, respectively, and the novel coronavirus nucleic acid detection item corresponds to nucleic acid amplification procedure KZ.

[0121] Specifically, the application environment includes a control terminal and a PCR multifunction device, and control software is installed on the control terminal. The control software has major functional modules, such as a sample module, a result module, a reagent module, a quality control module, a calibration module, and a setting module. As shown in FIG. 6, the control software interface has a guide area 601 on the left side, an experiment control area 602 at the top, and a function area 603 in the middle. The guide area 601 has function buttons such as Sample (6012), Result, Reagent, Quality Control, Calibration, Setting (6011), and Homepage. Clicking any of the function buttons displays the corresponding function interface in the function area 603. The experiment control area 602 has function buttons such as Start Experiment (6021), Pause Sample Addition, and Shutdown. Clicking any of the function buttons controls the PCR multifunction device to transition to the corresponding operating state.

[0122] The novel coronavirus nucleic acid detection for the above 10 samples mainly involves four aspects: setting the nucleic acid extraction procedure, setting the novel coronavirus nucleic acid detection items, sample registration, and experimental detection control, which are explained below.

[0123] 1. Nucleic Acid Extraction Procedure Setup First, it is necessary to set up procedures for each of the three nucleic acid extraction procedures, TQ1, TQ2, and TQ3, and obtain and store the procedure setting information for these three nucleic acid extraction procedures.

[0124] When the user clicks the settings button 6011 in the guide area 601, a software setting interface is displayed in the function area 603. When the user clicks the extraction procedure setting button in the interface, the control software displays a procedure setting interface, as shown in the upper diagram of FIG. 7 , which includes a mode pull-down box 701, a procedure list area 702, and a procedure editing area 703. The control software supports two information input modes: closed and open. When the closed option is selected in the mode pull-down box 701, the procedure list area 702 displays all nucleic acid extraction procedures created by the procedure two-dimensional code in a list format (hereinafter referred to as closed nucleic acid extraction procedures). A specific nucleic acid extraction procedure can then be selected in the procedure list area 702, and related content can be viewed in the procedure editing area 703. When the open option is selected in the mode pull-down box 701, the procedure list area 702 displays all nucleic acid extraction procedures (hereinafter referred to as open nucleic acid extraction procedures) created based on user operations in the procedure setting interface in a list format, and a specific nucleic acid extraction procedure can be selected in the procedure list area 702, and related content can be viewed and edited in the procedure editing area 703.

[0125] Below, we will explain the process of creating and setting three nucleic acid extraction procedures, TQ1, TQ2, and TQ3, in the control software using the closed and open types.

[0126] 1) When adopting a closed system The user scans the two-dimensional procedure code corresponding to the nucleic acid extraction procedure TQ1 using a code scanning gun. The control software then analyzes the two-dimensional procedure code information to obtain procedure setting information for the nucleic acid extraction procedure TQ1. Specifically, the setting information includes three setting items for the nucleic acid extraction procedure TQ1: basic procedure information, the transfer step, and the extraction step. The basic procedure information includes the procedure name, sample type, and sample addition amount. The transfer step includes the reagent composition and addition amount. The extraction step includes step distribution information and parameter setting information for each step (e.g., parameters such as time, rotation speed, and temperature for steps such as pyrolysis, magnetic attraction beads, binding, wash I, and wash II). Furthermore, the control software associates the procedure identifier for the nucleic acid extraction procedure TQ1 with the procedure setting information and stores it to create and configure the nucleic acid extraction procedure TQ1. The above procedure is then repeated to create and configure the nucleic acid extraction procedures TQ2 and TQ3.

[0127] As shown in the lower diagram of Figure 7, when the mode pull-down box 701 in the procedure setting interface corresponds to the closed-type option, the procedure list area 702 of the interface displays a list of nucleic acid extraction procedures TQ1, TQ2, and TQ3. Furthermore, when a user selects closed-type nucleic acid extraction procedure TQ1 in the procedure list area 702, the procedure editing area 703 displays a basic procedure information setting page instead of the setting pages for the liquid transfer step and extraction step. The basic procedure information setting page specifically displays the procedure name, sample type, and sample addition amount for nucleic acid extraction procedure TQ1. None of this public setting information is editable; it is only viewable by the user. The procedure list area 702 displays all closed-type nucleic acid extraction procedures that have already been created, including TQ1 to TQ3, along with any other closed-type nucleic acid extraction procedures that have been created. Clicking on any one of the nucleic acid extraction procedures in the procedure list area 702 is similar to clicking on TQ1, and therefore will not be described here.

[0128] 2) When using an open type In the control software, the public setting items for an open extraction procedure are pre-set to include three setting items: basic procedure information, transfer step, and extraction step. If necessary, the public setting information for each public setting item is pre-set so that, for example, the public setting information for the basic procedure information includes the procedure name, sample type, and sample addition amount, and the public setting information for the transfer step includes the reagent composition and addition amount, etc., and all are set to allow editing of the contents.

[0129] Based on this, as shown in the upper diagram of Figure 8, the control software displays a procedure setting interface, and when the user selects the open option in the mode pull-down box 801 in the interface, all open nucleic acid extraction procedures are centrally displayed in list form in the procedure list area 802 of the interface (the upper diagram of Figure 8 corresponds to the case where an open nucleic acid extraction procedure has not yet been created in the control software, so the procedure list area 802 is blank). In the procedure editing area 803, three tab options corresponding to three public setting items, namely, procedure basic information, liquid transfer step, and extraction step, are displayed, and the three tab options correspond to the setting pages of the three public setting items, respectively. In the procedure editing area 803, the setting page of the public setting item corresponding to the selected tab option is displayed. Specifically, the control software selects the tab option corresponding to the procedure basic information by default, so that the user can select the open option in the mode pull-down box 801 and directly display the setting page of the procedure basic information in the procedure editing area 803. Then, the user changes to and selects the tab option corresponding to the liquid transfer step, and switches to and displays the setting page of the liquid transfer step in the procedure editing area 803.

[0130] An Add New button is provided on the basic procedure information settings page, and when the user clicks this Add New button, the control software automatically enters the procedure name of the nucleic acid extraction procedure to be newly created in the procedure name field on the settings page (for example, a series of codes such as "20231213100907" is automatically entered, but the user is allowed to modify this themselves, and the user modifies it to TQ1, as shown in the lower diagram of Figure 8).Furthermore, when the user manually enters the sample type and sample addition amount for nucleic acid extraction procedure TQ1 on the settings page and then clicks the Save button on the settings page, the control software creates nucleic acid extraction procedure TQ1 and associates the procedure identifier of nucleic acid extraction procedure TQ1 with the entered procedure setting information and stores it, so as to set a setting item called basic procedure information.When the user clicks the Save button, nucleic acid extraction procedure TQ1 is added and displayed in the procedure list area 801, as shown in the lower diagram of Figure 8, and is automatically selected.

[0131] Furthermore, when the user selects the tag option corresponding to the liquid transfer step in the procedure editing area 803, the control software displays a setting page for the liquid transfer step, and when the user manually inputs setting information for the liquid transfer step of the nucleic acid extraction procedure TQ1 on the setting page, the control software associates the information entered by the user with the procedure identifier of the nucleic acid extraction procedure TQ1 and stores it so that the setting item called the liquid transfer step is set for the nucleic acid extraction procedure TQ1; and when the user clicks on the tag option corresponding to the setting item called the extraction step, the control software displays a setting page for the extraction step, and when the user manually inputs setting information for the extraction step on the setting page, the control software associates the information entered by the user with the procedure identifier of the nucleic acid extraction procedure TQ1 and stores it so that the setting item called the extraction step is set for the nucleic acid extraction procedure TQ1; up to this point, the control software has completed the creation and configuration of the open nucleic acid extraction procedure called TQ1.

[0132] The above procedure is then repeated to create and configure nucleic acid extraction procedures TQ2 and TQ3 (not shown).

[0133] 2. Nucleic acid detection item setting After creating and configuring nucleic acid extraction procedures TQ1, TQ2, and TQ3, create and configure the novel coronavirus nucleic acid detection item COVID.

[0134] When a user clicks the PCR item setting button in the software setting interface shown in FIG. 6 , the control software displays an item setting interface including a mode pull-down box 901, an item list area 902, and an item editing area 903, as shown in the upper diagram of FIG. 9 . Similarly, the control software supports two information input modes: closed and open. When the closed option is selected in the mode pull-down box 901, all nucleic acid detection items created by item two-dimensional codes (hereinafter referred to as closed nucleic acid detection items) are displayed in a list format in the item list area 902. A specific closed nucleic acid detection item can be selected in the item list area 902, and related content can be viewed and edited in the item editing area 903. When the open option is selected in the mode pull-down box 901, all nucleic acid detection items created based on user operations in the item setting interface (hereinafter referred to as open nucleic acid detection items) are displayed in a list format in the item list area 902. A specific open nucleic acid detection item can be selected from the item list area 902, and related content can be viewed and edited in the item editing area 903. (Note that the upper diagram in FIG. 9 shows a case where it is assumed that the control software has created only two closed nucleic acid detection items, "HPV (closed)" and "HBV (closed)," before creating the novel coronavirus nucleic acid detection item COVID, and therefore only these two are displayed in the item list area 902.) The following describes the process of creating and configuring the COVID novel coronavirus nucleic acid detection item in the control software using the closed and open methods.

[0135] 1) When adopting a closed system The user uses a code scanning gun to scan the item two-dimensional code corresponding to the novel coronavirus nucleic acid detection item COVID, and the control software analyzes the item two-dimensional code information to obtain item setting information for the novel coronavirus nucleic acid detection item COVID, specifically including setting information for seven setting items: item basic information, reagent composition, detection target, result judgment, nucleic acid extraction procedure, nucleic acid amplification procedure, and quality control settings for the novel coronavirus nucleic acid detection item COVID, and furthermore, the control software associates the item identifier of the novel coronavirus nucleic acid detection item COVID with the above item setting information and stores it, and thus the creation and setting of this novel coronavirus nucleic acid detection item COVID has been completed.

[0136] For basic item information, the item 2D code is analyzed to specifically obtain the item abbreviation, item name, item type, item number, LIS channel number, number of repetitions, result unit, display order, nucleic acid addition amount, and exogenous internal standard for the COVID novel coronavirus nucleic acid detection item. For nucleic acid extraction procedures, the procedure mapping relationship for the COVID novel coronavirus nucleic acid detection item is obtained, i.e., the one-to-one mapping relationship between the three sample types (throat swab, serum, and feces) and the three nucleic acid extraction procedures (TQ1, TQ2, and TQ3). For nucleic acid amplification procedures, the procedure setting information for the nucleic acid amplification procedure KZ is obtained, which may specifically include the aforementioned procedure segment distribution information and specific procedure segment setting information. The four setting items (reagent composition, detection target, result judgment, and quality control settings) are not the focus of this application, and as long as the related setting information meets the standard requirements in this field, they will not be described here.

[0137] Furthermore, when the mode pull-down box 901 in the item setting interface corresponds to the closed option, as shown in the lower diagram of Figure 9, the item list area 902 of the interface displays all closed nucleic acid detection items that have already been created in list format, including HPV (closed), HBV (closed), and the novel coronavirus nucleic acid detection item COVID.

[0138] When the user selects the novel coronavirus nucleic acid detection item COVID in the item list area 902, tab options 9031 and 9032 corresponding to two setting items, item basic information and quality control settings, respectively, are displayed in the item editing area 903. The two tab options correspond to the item basic information setting page and quality control settings setting page, respectively, and the setting page for the public setting item corresponding to the selected tab option is displayed in the item editing area 903. Specifically, the control software selects tag option 9031 corresponding to the item basic information by default, thereby displaying the item basic information setting page for the novel coronavirus nucleic acid detection item COVID by default in the item editing area 903. The user then changes to and selects tag option 9032 corresponding to quality control settings, and switches to and displays the setting page for the novel coronavirus nucleic acid detection item COVID in the item editing area 903. Specifically, some of the information displayed on the settings page, such as the item abbreviation, item name, item type, and item number in the item basic information, are not allowed to be edited and are only allowed to be viewed by the user, while other information, such as the LIS channel number, number of repetitions, result unit, display order, and quality control type required for each batch experiment in the quality control settings, are allowed to be both viewed and edited by the user.

[0139] 2) When using an open type In the control software, the public setting items for the open-type nucleic acid detection item include seven setting items: item basic information, reagent composition, detection target, result judgment, nucleic acid extraction procedure, nucleic acid amplification procedure, and quality control settings. Of these, the public setting information for the item basic information includes item abbreviation, item name, item type, item number, LIS channel number, number of repetitions, result unit, display order, nucleic acid addition amount, and exogenous internal standard. The public setting information for the nucleic acid extraction procedure includes the procedure mapping relationship, i.e., the mapping relationship between the sample type and the nucleic acid extraction procedure. The public setting information for the nucleic acid amplification procedure is pre-set to include procedure segment distribution information and specific setting information for the procedure segment, and all of the contents are set to be editable. The four setting items, reagent composition, detection target, result judgment, and quality control settings, are not the focus of this application. As long as their public setting information meets the conventional requirements in this field, their description will be omitted here.

[0140] Based on this, as shown in the upper diagram of Figure 10, the control software displays an item setting interface. When the user selects the open option in the mode pull-down box 1001 of the interface, all open-type nucleic acid extraction items that have already been created are centrally displayed in a list format in the item list area 1002 (the upper diagram of Figure 10 corresponds to a case where no open-type nucleic acid detection items have yet been created in the control software, so the item list area 1002 is blank). The item editing area 1003 displays seven tab options corresponding to the seven public setting items, respectively. The seven tab options correspond to the setting pages of the seven public setting items, and the item editing area 1003 displays the setting page of the public setting item corresponding to the selected tab option. Specifically, the control software selects the tab option corresponding to the item basic information by default. Therefore, when the user selects the open option in the mode pull-down box 1001, the item editing area 1003 directly displays the setting page of the item basic information. Then, the user changes to and selects the tab option corresponding to the nucleic acid extraction procedure, and the item editing area 1003 switches to and displays the setting page of the nucleic acid extraction procedure.

[0141] An Add New button is provided on the item basic information settings page. When the user clicks the Add New button and then manually enters the basic item information for the novel coronavirus nucleic acid detection item COVID, including the item abbreviation, item name, item type, etc. on the settings page and clicks the Save button, the control software creates the novel coronavirus nucleic acid detection item COVID and associates the entered basic item information with the item identifier of the novel coronavirus nucleic acid detection item COVID, setting a settings item called item basic information. After the user clicks the Save button, the novel coronavirus nucleic acid detection item COVID is added and displayed in the item list area 1002 and automatically selected, as shown in the lower figure of Figure 10.

[0142] Furthermore, when the user selects the tag option corresponding to the nucleic acid extraction procedure in the item editing area 1003, the control software displays the setting page for the nucleic acid extraction procedure for the novel coronavirus nucleic acid detection item COVID, and the user performs the relevant operations in the interface to input the sample type and nucleic acid extraction procedure for the novel coronavirus nucleic acid detection item COVID.

[0143] Specifically, as shown in the example corresponding to FIG. 3, when a user clicks the Add New button on the setting page, the control software displays an extraction procedure pop-up box including a sample type pull-down box and a nucleic acid extraction procedure pull-down box. When a user selects a throat swab sample type in the sample type pull-down box, the control software obtains a corresponding type identifier and determines a nucleic acid extraction procedure associated with the throat swab sample type based on the type identifier and the procedure setting information of multiple pre-stored nucleic acid extraction procedures. For example, suppose that only the procedure setting information of three nucleic acid extraction procedures, TQ1, TQ2, and TQ3, is pre-stored. Then, nucleic acid extraction procedure TQ1 is determined as the nucleic acid extraction procedure associated with the throat swab sample type. Only nucleic acid extraction procedure TQ1 is displayed in the nucleic acid extraction procedure drop-down box. When the user selects nucleic acid extraction procedure TQ1, the control software obtains the procedure identifier for nucleic acid extraction procedure TQ1. When the user clicks the Save button in the pop-up box, the control software associates the type identifier of the throat swab sample type with the procedure identifier of nucleic acid extraction procedure TQ1 and stores it, thereby obtaining a mapping relationship between the two. That is, the throat swab sample type is input for the novel coronavirus nucleic acid detection item COVID, and the corresponding nucleic acid extraction procedure TQ1 is determined. Then, the above operation is repeated, and two sample types, serum and stool, are input for the novel coronavirus nucleic acid detection item COVID, and the corresponding nucleic acid extraction procedures TQ2 and TQ3 are determined. Thus, the control software has obtained a one-to-one mapping relationship between the three sample types and the three nucleic acid extraction procedures, that is, the procedure mapping relationship for the novel coronavirus nucleic acid detection item COVID.

[0144] Then, when the user selects a tag option corresponding to the nucleic acid amplification procedure in the item editing area 1003, the control software displays a setting page for the nucleic acid amplification procedure, and when the user manually enters the procedure setting information for the nucleic acid amplification procedure on the setting page and clicks the save button, the control software stores the basic procedure information entered by the user in association with the item identifier of the novel coronavirus nucleic acid detection item COVID, and sets the nucleic acid amplification procedure for that item.

[0145] In addition, when the user selects tag options corresponding to the reagent composition, detection target, result judgment, and quality control settings, the control software will display the corresponding setting page, and the user can manually enter the setting information corresponding to the novel coronavirus nucleic acid detection item COVID on the setting page, and the control software will set the setting items corresponding to the novel coronavirus nucleic acid detection item COVID. However, these setting items are not the focus of this application and can be realized in any application method, so their description will be omitted here.

[0146] So far, the control software has completed the creation and configuration of the novel coronavirus nucleic acid detection item COVID.

[0147] 3. Sample Registration After creating and setting the COVID novel coronavirus nucleic acid detection item, register the samples for the above 10 samples to enter sample information and register items waiting to be detected.

[0148] Specifically, when a user places 10 samples in the sample chamber of the PCR multifunction peripheral and then clicks the sample button 6012 in the guide area 601 shown in Fig. 6, the control software displays a sample registration interface (not shown). The sample registration interface displays 10 samples awaiting detection that correspond one-to-one with the 10 samples. The user inputs sample information for each of the 10 samples awaiting detection in the sample registration interface, for example, by inputting the sample type. Specifically, the sample types input for three of the samples awaiting detection are throat swabs, the other three are serum, and the remaining four are feces. Furthermore, when the user checks the 10 samples awaiting detection and clicks the item registration button in the sample registration interface, the control software will display an item registration pop-up box, which will display all detection items already created in the control software, including the novel coronavirus detection item COVID. When the user selects the novel coronavirus detection item COVID and clicks the confirm button, the control software will bind the sample identifiers of the 10 samples awaiting detection with the item identifier of the novel coronavirus detection item COVID, i.e., register the novel coronavirus detection item COVID for the 10 samples awaiting detection.

[0149] 4. Experimental Detection After sample registration is completed, when the user clicks the start experiment button 6021 in the experiment control area 602 shown in FIG. 6, the control software can control the PCR multifunction machine to perform the relevant experiment operations.

[0150] Specifically, the control software divides test batches for samples awaiting detection, and samples awaiting detection that are divided into the same test batch have the same sample type and awaiting detection item. Since all 10 samples awaiting detection are registered with the novel coronavirus detection item COVID, they are divided into three test batches corresponding to the three sample types. Furthermore, the control software controls the PCR multifunction device to perform corresponding experimental operations for each experimental batch. Taking the experimental batch containing three throat swab samples awaiting detection as an example, the control software controls the PCR multifunction device to perform operations such as setting the extraction plate, setting the amplification plate, adding samples, extracting nucleic acid, transferring nucleic acid, and amplifying nucleic acid in the corresponding experimental operation manner based on the type identifier of the throat swab sample type and the item setting information for the novel coronavirus nucleic acid detection item COVID. Thus, the PCR multifunction device obtains and transmits the experimental detection data for the three samples awaiting detection to the control software.

[0151] For the nucleic acid extraction portion, the control software searches for the procedure identifier for the nucleic acid extraction procedure TQ1 in the procedure mapping relationship for the novel coronavirus nucleic acid detection item COVID based on the type identifier of the throat swab sample type and the item identifier for the novel coronavirus nucleic acid detection item COVID. The control software then searches for the procedure setting information for the nucleic acid extraction procedure TQ1 based on the procedure identifier. The control software then controls the PCR multifunction device to perform the nucleic acid extraction process according to the experimental procedure specified by the procedure setting information. For the nucleic acid amplification portion, the control software searches for the procedure setting information for the nucleic acid amplification procedure for the novel coronavirus nucleic acid detection item COVID based on the item identifier for the novel coronavirus nucleic acid detection item COVID. As mentioned above, controlling the PCR multifunction device to complete all experimental procedures for one experimental batch involves numerous processes, such as quality control and calibration. However, these are not the focus of this application and can be achieved using any applicable method in this field, and therefore will not be described here.

[0152] The control software then controls the PCR multifunction machine to perform the corresponding experimental operations for the experimental batches containing the three serum samples and four fecal samples in a similar manner, thereby obtaining and transmitting the experimental detection data for these seven samples to the control software (details are omitted). Thus far, 10 samples have been successfully tested for novel coronavirus nucleic acid.

[0153] Although the steps in the flowcharts according to the above-described embodiments are displayed sequentially according to the direction of the arrows, it should be reasonably understood that these steps are not necessarily performed sequentially according to the order indicated by the arrows. Unless otherwise specified in this specification, the order in which these steps are performed is not strictly limited, and these steps may be performed in other orders. Furthermore, at least some of the steps in each flowchart may include multiple substeps or multiple stages, and these substeps or stages do not necessarily have to be performed at the same time but may be performed at different times. The order in which these substeps or stages are performed is also not necessarily sequential, and they may be performed in order or alternately with other steps or at least some of the substeps or stages of other steps.

[0154] In one embodiment, as shown in FIG. 11, a detection item setting device 1100 is further provided, which includes the following modules 1102 to 1106.

[0155] The mapping relationship acquisition module 1102 is for acquiring a procedure mapping relationship of a target detection item, where the procedure mapping relationship includes a mapping relationship between a plurality of target sample types and at least one target first experimental procedure.

[0156] The procedure setting acquisition module 1104 is for acquiring procedure setting information of the target second experimental procedure, and the target second experimental procedure uniquely corresponds to the item type of the target detection item.

[0157] The detection item setting module 1106 is for setting target detection items based on the procedure mapping relationship and the procedure setting information of the target second experiment procedure.

[0158] The detection item setting device obtains a mapping relationship between multiple sample types corresponding to a target detection item and at least one first experimental procedure, obtains procedure setting information for a second experimental procedure that uniquely corresponds to the item type of the target detection item, and sets the target detection item based on the mapping relationship and procedure setting information. This allows a first experimental procedure corresponding to different sample types to be set for one detection item. When one detection item has multiple sample types, it is not necessary to create a separate detection item for each sample type; only one detection item is required. This simplifies the item setting and subsequent modification work and improves the convenience and efficiency of item setting. Furthermore, since only one detection item is displayed in the sample registration interface for the same type of detection item, confusion is effectively avoided when the user registers samples, and the registration efficiency and accuracy are improved.

[0159] In one embodiment, the mapping relationship acquisition module 1102 includes a sample type determination module, a first experimental procedure determination module, and a mapping relationship acquisition module, wherein the sample type determination module is for determining multiple target sample types based on a user's sample type input operation in the item setting interface, the first experimental procedure determination module is for determining, for each target sample type, a first experimental procedure associated with the target sample type based on pre-stored procedure setting information of the first experimental procedure, and for determining a target first experimental procedure corresponding to the target sample type from the associated first experimental procedures based on a user's procedure selection operation in the item setting interface, and the mapping relationship acquisition module is for acquiring procedure mapping relationships of target detection items based on the determined multiple target sample types and the corresponding target first experimental procedures.

[0160] In one embodiment, the detection item setting device 1100 includes an item basic information acquisition module and a first detection item creation module. The item basic information acquisition module is for acquiring item basic information of a target detection item based on a user's basic information input operation in the item setting interface, and the first detection item creation module is for creating a target detection item based on the item basic information in response to a user's new item creation operation. Based on this, the detection item setting module 1106 includes a detection item update module for updating the target detection item based on the procedure mapping relationship and the procedure setting information of the second experimental procedure.

[0161] In one embodiment, the mapping relationship acquisition module 1102 includes a first analysis module for analyzing the item graphic code information scanned and acquired by the code scanning device to acquire the procedure mapping relationship of the target detection item.

[0162] In one embodiment, the detection item setting device 1100 includes a second analysis module for analyzing the item graphic code to obtain item basic information of the target detection item. Based on this, the procedure setting acquisition module 1104 includes a third analysis module for analyzing the item graphic code to obtain procedure setting information of the target second experimental procedure. And the detection item setting module 1106 includes a second detection item creation module for creating and setting the target detection item based on the item basic information, the procedure mapping relationship, and the procedure setting information of the target second experimental procedure.

[0163] In one embodiment, the detection item setting device 1100 includes: a setting interface display module for displaying an item setting interface, the item setting interface including a mode selection control, an item list area, and an item editing area, the mode selection control including an open option and a closed option; an open-type item display module for displaying open-type detection items in the item list area when the mode selection control corresponds to an open-type option, the open-type detection items including detection items created based on a user's operation on the item setting interface; an open-type setting page display module for displaying a setting page corresponding to a selected open-type detection item in an item editing area based on a selection operation for the displayed open-type detection item, the setting page corresponding to the open-type detection item including a setting page for a first experimental procedure and a setting page for a second experimental procedure; a closed-type item display module for displaying closed-type detection items in the item list area when the mode selection control corresponds to a closed-type option, the closed-type detection items including detection items created by item graphic codes; The closed-type setting page display module may include a closed-type setting page display module for displaying a setting page corresponding to a selected closed-type detection item in an item editing area based on a selection operation for the displayed closed-type detection item, wherein the setting page corresponding to the closed-type detection item does not include a setting page for a first experimental procedure and a setting page for a second experimental procedure.

[0164] In one embodiment, the detection item setting device 1100 includes: A first item acquires and stores procedure setting information for the first target experimental procedure, including basic procedure information and experimental step information for the first target experimental procedure, based on a user's procedure information input operation on the procedure setting interface; and a second item that analyzes the procedure graphic code information scanned and acquired by the code scanning device to acquire and store procedure setting information for the target first experimental procedure, including basic procedure information and experimental step information for the target first experimental procedure.

[0165] In one embodiment, the detection item setting device 1100 includes a registration interface display module, a sample to be registered determination module, an item to be detected determination module, and a registration module, wherein the registration interface display module is for displaying a sample registration interface displaying samples to be detected and candidate detection items, where the samples to be detected have a one-to-one correspondence with the target entity samples placed in the sample analysis device, the sample to be registered determination module is for determining samples to be registered from the samples to be detected based on a sample selection operation in the sample registration interface, the item to be detected determination module is for determining items to be detected from the candidate detection items based on an item selection operation in the sample registration interface, and the registration module is for registering the items to be detected for the samples to be registered in response to a registration trigger operation.

[0166] In one embodiment, the detection item setting device 1100 includes an experimental batch classification module and an experiment control module. In response to an experiment start operation, the experimental batch classification module classifies the experimental batch for samples to be detected based on the sample type and the items to be detected of the samples to be detected, where the samples to be detected in the same experimental batch have the same sample type and items to be detected, or the samples to be detected in the same experimental batch correspond to the same first experimental procedure and have the same items to be detected. The experiment control module controls the sample analysis instrument to perform corresponding experimental operations on target entity samples corresponding to the samples to be detected in the experimental batch based on the sample type of the experimental batch, the procedure mapping relationship of the items to be detected in the experimental batch, and the procedure setting information of the second experimental procedure.

[0167] Note that specific limitations on the detection item setting device 1100 can be found in the limitations on the detection item setting method described above, and therefore a detailed description thereof will be omitted here. Each module in the detection item setting device 1100 described above may be realized in whole or in part by software, hardware, or a combination thereof. Each module may be embedded in or stand-alone in a processor in a computer device in the form of hardware, or may be stored in a memory in a computer device in the form of software so that the processor can call and execute operations corresponding to each module.

[0168] In one embodiment, a control terminal is provided that includes a memory and a processor, wherein a computer program is stored in the memory, and when the processor executes the computer program, the control terminal implements the steps of the detection item setting method provided by any one of the embodiments of the present application.

[0169] Specifically, the internal configuration of the control terminal includes a processor, memory, a network interface, a display screen, an input device, and an audio collection device, all connected via a system bus, as shown in FIG. 12. The processor provides computing and control capabilities. The memory includes a non-volatile storage medium and an internal memory. The non-volatile storage medium of the control terminal stores an operating system and a computer program. When the computer program is executed by the processor, the processor can implement the detection item setting method provided by any one of the embodiments of the present application. The internal memory provides an environment for the operation of the operating system and the computer program stored in the non-volatile storage medium. The network interface is for connecting and communicating with external terminals via a network. The display screen may be a liquid crystal display or an electronic ink display. The input device may be a touch screen coated on the display screen, a button, a trackball, or a touch panel on the case of the computer device, or an external keyboard, touch panel, or mouse. As will be understood by those skilled in the art, the configuration shown in FIG. 12 is merely a block diagram of a portion of the configuration of the technical solution of the present application, and is not intended to limit the control terminal to which the technical solution of the present application is applied; a specific control terminal may include more or fewer components than those shown in FIG. 12, may combine certain components, or may have a different component arrangement.

[0170] In one embodiment, the detection item configuration device provided in the present application can be realized as a computer program operable on a control terminal shown in Fig. 12. The memory of the control terminal stores program modules constituting the device, such as the mapping relationship acquisition module 1102 and procedure setting acquisition module 1104 shown in Fig. 11. The computer program constituted by the program modules causes a processor to execute steps in the detection item configuration method according to each embodiment of the present application described in this specification. For example, the control terminal shown in Fig. 12 may cause the mapping relationship acquisition module 1102 in the detection item configuration device 1100 shown in Fig. 11 to execute step S202 and the procedure setting acquisition module 1104 to execute step S204.

[0171] Those skilled in the art will understand that implementing all or part of the steps in the above-described method embodiments can be accomplished by instructing relevant hardware to complete the process using a computer program. The program can be stored in a non-volatile computer-readable storage medium and, when executed, can include the steps of the above-described method embodiments. Any references to memory, storage, databases, or other media used in the embodiments provided herein may include non-volatile and / or volatile memory. Non-volatile memory may include read-only memory (ROM), programmable read-only memory (PROM), electrically programmable read-only memory (EPROM), electrically erasable programmable read-only memory (EEPROM), or flash memory. Volatile memory may include random access memory (RAM) or external cache memory. Unless otherwise specified, RAM can be implemented in various forms, such as SRAM (Static RAM), DRAM (Dynamic RAM), SDRAM (Synchronous Dynamic RAM), DDRSDRAM (Double Data Rate Synchronous Dynamic RAM), ESDRAM (Enhanced Synchronous Dynamic RAM), SLDRAM (Synchlink Dynamic RAM), RDRAM (Rambus Direct RAM), DRDRAM (Direct Rambus Dynamic RAM), and RDRAM (Rambus Dynamic RAM).

[0172] Accordingly, in one embodiment, a computer-readable storage medium is provided that stores a computer program that, when executed by a processor, causes the processor to perform the steps of a detection item setting method according to any one of the embodiments of the present application.

[0173] In one embodiment, the system includes a sample analysis instrument and the above-mentioned control terminal, wherein the control terminal is configured to acquire and store procedure mapping relationships for target detection items and procedure setting information for target second experimental procedures, wherein the procedure mapping relationships include mapping relationships between multiple target sample types and at least one target first experimental procedure, and wherein the target second experimental procedure and the item type of the target detection items uniquely correspond to each other. The control terminal is also configured to sort experimental batches for the samples to be detected based on the sample types and the items to be detected of the samples to be detected, and to send experimental control commands to the sample analysis instrument for each experimental batch based on the procedure mapping relationships for the sample types and the items to be detected of the experimental batch and the procedure setting information of the second experimental procedure, wherein the samples to be detected in the same experimental batch have the same sample types and items to be detected, or the samples to be detected in the same experimental batch correspond to the same first experimental procedure and have the same items to be detected. The sample analysis instrument is configured to perform corresponding experimental operations on the actual samples corresponding to the samples to be detected in each experimental batch based on the experimental control commands.

[0174] The technical features of the above embodiments can be combined in any way, and for the sake of brevity, not all combinations of the technical features in the above embodiments are described, but as long as the combinations of these technical features are not contradictory, they should be considered to be within the scope described in this specification.

[0175] The above examples merely illustrate some embodiments of the present application, and although they have been specifically and in detail described, they should not be understood as limiting the scope of the claims of the present application. Those skilled in the art may make minor modifications and improvements without departing from the concept of the present application, and all of these are within the scope of protection of the present application. Therefore, the scope of protection of the present application should be determined by reference to the appended claims.

Claims

1. obtaining a procedure mapping relationship for a target detection item, the procedure mapping relationship including a mapping relationship between a plurality of target sample types and at least one target first experimental procedure; a step of acquiring procedure setting information of a target second experimental procedure, the target second experimental procedure uniquely corresponding to the item type of the target detection item; and setting the target detection items based on the procedure mapping relationship and procedure setting information of the target second experimental procedure. A method for setting detection items, comprising:

2. The step of obtaining a procedure mapping relationship of the target detection items includes: determining a plurality of target sample types based on a user's sample type input operation in the item setting interface; For each of the target sample types, determining a first experimental procedure associated with the target sample type based on procedure setting information of the first experimental procedure stored in advance, and determining a target first experimental procedure corresponding to the target sample type from the associated first experimental procedures based on a procedure selection operation by a user on the item setting interface; and obtaining a procedure mapping relationship of target detection items based on the determined plurality of target sample types and their corresponding target first experimental procedures.

2. The method of claim 1 .

3. Before the step of obtaining a procedure mapping relationship of the target detection item, acquiring basic item information of the target detection item based on a user's basic information input operation in an item setting interface; and creating the target detection item based on the item basic information in response to a user's operation to create a new item, The step of setting the target detection items based on the procedure mapping relationship and procedure setting information of the target second experimental procedure includes: updating the target detection items based on the procedure mapping relationship and procedure setting information of the second experimental procedure; 3. The method of claim 2.

4. The step of obtaining a procedure mapping relationship of the target detection items includes: Analyzing the item graphic code information to obtain the procedure mapping relationship of the target detection item, the item graphic code information being obtained by scanning with a code scanning device; 2. The method of claim 1 .

5. before the step of setting the target detection items based on the procedure mapping relationship and the procedure setting information of the target second experimental procedure; The method further includes analyzing the item graphic code information to obtain item basic information of the target detection item; The step of acquiring procedure setting information of the target second experimental procedure includes: Analyzing the item graphic code to obtain procedure setting information of a target second experimental procedure; The step of setting the target detection items based on the procedure mapping relationship and procedure setting information of the target second experimental procedure includes: creating and setting a target detection item based on the item basic information, the procedure mapping relationship, and procedure setting information of the target second experimental procedure; 5. The method of claim 4.

6. displaying an item setting interface, the item setting interface including a mode selection control, an item list area, and an item editing area, the mode selection control including an open option and a closed option; If the mode selection control corresponds to an open option, displaying open detection items in the item list area, the open detection items including detection items created based on a user's operation on the item setting interface; a step of displaying a setting page corresponding to the selected open-type detection item in the item editing area based on a selection operation for the displayed open-type detection item, the setting page corresponding to the open-type detection item including a setting page for the first experimental procedure and a setting page for the second experimental procedure; If the mode selection control corresponds to a closed option, displaying closed detection items in the item list area, the closed detection items including detection items created by item graphic code information; and a step of displaying a setting page corresponding to the selected closed-type detection item in the item editing area based on a selection operation for the displayed closed-type detection item, wherein the setting page corresponding to the closed-type detection item does not include a setting page for the first experimental procedure and a setting page for the second experimental procedure.

3. The method of claim 2.

7. acquiring and storing procedure setting information for a first target experimental procedure based on a user's procedure information input operation on a procedure setting interface, the procedure setting information including basic procedure information and experimental step information for the first target experimental procedure; analyzing the procedure graphic code information to obtain and store procedure setting information of the target first experimental procedure, the procedure graphic code information being obtained by scanning with a code scanning device, and the procedure setting information including at least one of procedure basic information and experiment step information of the target first experimental procedure; 2. The method of claim 1 .

8. displaying a sample registration interface, wherein the sample registration interface displays samples to be detected and candidate detection items, the samples to be detected corresponding one-to-one to target entity samples to be placed in the sample analysis device; determining samples to be registered from the samples to be detected based on a sample selection operation in the sample registration interface; determining a waiting-to-detect item from the candidate detection items based on an item selection operation in the sample registration interface; and registering the item waiting to be detected for the sample waiting to be registered in response to a registration trigger operation.

2. The method of claim 1 .

9. In response to an experiment start operation, a step of dividing an experimental batch into samples awaiting detection based on the sample type and the item awaiting detection of the samples awaiting detection, wherein the samples awaiting detection in the same experimental batch have the same sample type and the item awaiting detection, or the samples awaiting detection in the same experimental batch correspond to the same first experimental procedure and have the same item awaiting detection; For each of the experimental batches, the method further includes controlling a sample analysis device to perform a corresponding experimental operation on a target entity sample corresponding to the sample to be detected in the experimental batch according to the sample type of the experimental batch, the procedure mapping relationship of the items to be detected in the experimental batch, and the procedure setting information of the second experimental procedure; 9. The method of claim 8.

10. a mapping relationship acquisition module for acquiring a procedure mapping relationship of a target detection item, the procedure mapping relationship including a mapping relationship between a plurality of target sample types and at least one target first experimental procedure; a procedure setting acquisition module for acquiring procedure setting information of a target second experimental procedure, the target second experimental procedure uniquely corresponding to the item type of the target detection item; a detection item setting module for setting the target detection items based on the procedure mapping relationship and procedure setting information of the target second experimental procedure; A detection item setting device characterized by:

11. A computer-readable storage medium on which a computer program is stored, The computer program, when executed by a processor, causes the processor to perform the steps of the method according to any one of claims 1 to 9. A computer-readable storage medium comprising:

12. A control terminal comprising a memory and a processor, wherein a computer program is stored in the memory, When said processor executes said computer program, it implements the steps of the method according to any one of claims 1 to 9.

1. A control terminal comprising:

13. a sample analysis device and the control terminal according to claim 12, wherein the sample analysis device and the control terminal are communicatively connected; the control terminal is for acquiring and storing procedure mapping relationships of target detection items and procedure setting information of target second experimental procedures, the procedure mapping relationships including mapping relationships between a plurality of target sample types and at least one target first experimental procedure, and the target second experimental procedure uniquely corresponding to the item type of the target detection item; The control terminal is also used to classify experimental batches for the samples waiting to be detected based on the sample types and items waiting to be detected of the samples waiting to be detected, and to send experimental control commands to the sample analysis device for each of the experimental batches based on the procedure mapping relationship between the sample types and items waiting to be detected of the experimental batches and the procedure setting information of the second experimental procedure, whereby the samples waiting to be detected in the same experimental batch have the same sample types and items waiting to be detected, or the samples waiting to be detected in the same experimental batch correspond to the same first experimental procedure and have the same items waiting to be detected; The sample analysis device is configured to perform corresponding experimental operations on actual samples corresponding to samples to be detected in each of the experimental batches based on the experimental control instructions. A sample analysis system characterized by:

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