Combined imaging system and method

Abstract

To provide a combining and display method associated with cardiac cycle data of both a live patient image and a non-live blood vessel image data patient image.SOLUTION: A combined imaging method includes collecting angiography image data, and correlating an angiography image frame with time-varying data related to a cardiac cycle of a patient. The time-varying data may be compared with live cardiac cycle data of the patient such that the collected angiography image frame may be interlaced within display of a live fluoroscopic image of the patient.SELECTED DRAWING: Figure 9

Description

[Technical Field]

[0001] This disclosure relates generally to the field of vascular imaging and data acquisition systems and methods. In particular, the present disclosure provides a method for capturing live images, such as fluoroscopic images, in combination with co-registered angiographic frames. A method for providing an X-ray image.

[0002] [CROSS-REFERENCE TO RELATED APPLICATIONS] This application is a continuation of U.S. Provisional Patent Application No. 62 / 902,948, filed September 19, 2019. No. 60 / 019,999, filed on Oct. 1, 2002, the disclosure of which is incorporated herein by reference. Let's say. [Background technology]

[0003] Coronary artery disease is one of the leading causes of death worldwide. The ability to treat and treat can be life-saving. A variety of medical and technical personnel Includes angiographic and live fluoroscopic imaging as part of stent planning or delivery You are browsing multiple sources of information. Switching between these two data sources can be tiring. Such personnel must use fluoroscopic vision as part of stent planning and delivery. Mentally associate images and other data when switching from a change in view to an angiogram It is therefore often necessary to provide useful diagnostic information and to improve planning and cardiovascular There exists a need for systems, methods, and devices that improve imaging for systemic procedures. are.

[0004] The present disclosure addresses these and other challenges. Summary of the Invention

[0005] In part, the present disclosure relates to converting live fluoroscopy image data into angiography image data. The present invention relates to a system and method for co-registering a first image with a second image. During a session, a first set of time-varying data corresponding to the cardiac cycle at one or more time points is collected. acquiring, wherein the first imaging session produces a set of angiographic frames; and angiographic imaging of the subject for obtaining blood flow corresponding to a first subset of the time-varying data. identifying a vascular contrast frame and, during the second imaging session, tracking or collecting a second set of time-varying data corresponding to a cardiac cycle, wherein the second The imaging session is used to generate a set of live fluoroscopy and angiography frames. The method includes live fluoroscopic imaging of a subject for imaging, converting a first set of time-varying data into a second set of time-varying data. and correlating the data to identify an angiography frame that corresponds to the live fluoroscopy frame. , one or more live fluoroscopy frames of a first set and one or more live fluoroscopy frames of a second set. and displaying one or more angiographic frames corresponding to the frame.

[0006] Various sources and streams of intravascular and peripheral vascular image data are described herein. In addition, various cardiovascular signals can be combined and interlaced as disclosed in Co-register two or more imaging modalities using signals and rhythms, then co-register One or both of the co-registered imaging modalities may be fluoroscopy, cine, or is used in catheter laboratories ("cath labs") for other live imaging, etc. It can support combining with live image data. One or more devices is a combination of one or more user interfaces and endovascular data or data derived from such data. Other information can be displayed: intravascular data, IVUS or OCT-based data It can be acquired using an acquisition system and probe or other imaging modality. The method involves the display of endovascular data and user interface via a graphic user interface (GUI). and receives user input and includes one or more image processing and frame selection software components. Implemented using one or more computing devices and memory storage, including The computing device may be a microprocessor, an ASIC, or a It may be any other processor suitable for use with an endoscopy imaging system.

[0007] In part, this disclosure uses a combination of live fluoroscopy and angiography frames. The present invention relates to a system and method for evaluating and deploying a stent using an interlaced catheter. The combination of frames is used for imaging, analysis and diagnostic systems and the aforementioned combinations. Supports enhanced atherectomy, stent placement, and balloon-based treatments. The present disclosure provides a method for one or more processors to generate a first set of subjects captured during a first time period. acquiring an image and a first set of time-varying data corresponding to the subject's cardiac cycle during a first period of time; and one or more processors extracting a subset of the first set of subject images into a first section. and correlating the time-varying data subset of the second period with the one or more processors. a second set of subject images captured during the second period and a second set of subject images captured during the second period; a second set of time-varying data corresponding to the period; and , correlating a first set of time-varying data with a second set of time-varying data; and a processor for generating a first set of test data corresponding to a subset of the second set of time-varying data; identifying one or more image frames from the subject image; and one or more processors a first set of subject images interlaced with a plurality of image frames from a second set of subject images; and providing the identified one or more image frames from the examiner image for display. , systems and methods are provided.

[0008] According to the present disclosure, the first set of subject images may be angiographic images, and the second set of The image of the subject in the image may be a fluoroscopic image. In addition, the fluoroscopic image may be a live image of the subject. and the second set of time-varying data may be the subject's live cardiac cycle data. good.

[0009] According to another aspect of the disclosed systems and methods, a first set of time-varying data and a second set of time-varying data are The set of time-varying data may include aortic (AO) pressure values ​​and / or ECG values. Additionally, the first period may include an intravascular probe having one or more opaque markers, such as an OCT. Alternatively, the method may include simultaneously intravascularly imaging the subject using an IVUS probe or the like. Intravascular imaging of the subject produces a set of intravascular image frames. The system co-registers the intravascular image frames with the first set of subject images. The system may also be configured to include one or more live angiography frames. The system may be configured to display these or any subset of the intravascular image frames.

[0010] The disclosed system also includes a plurality of image frames from a second set of subject images. one or more identified image frames from the first set of interlaced subject images. The interlacing of the image frames may be configured to display the second One or more image frames from the first set of subject images are combined with one or more image frames from the second set of subject images. According to an aspect of the present disclosure, the second image may be replaced with one or more image frames. one or more image frames from the first set of subject images and one or more image frames from the second set of subject images One or more image frames are each acquired during a corresponding portion of the patient's cardiac cycle. The system may also include a first set of subject images interleaved with image frames from the second set of subject images. and inserting the identified one or more image frames from the first subject image into the second image frame. a first set of image frames interlaced with a plurality of image frames from a second set of subject images; may be configured to display one or more identified image frames from the subject image. .

[0011] The present invention relates to different aspects and embodiments, but the different aspects and embodiments disclosed herein are The embodiments may be integrated together in whole or in part as desired. It is understood that each embodiment disclosed herein may be implemented in a variety of ways. Each of the aspects may be incorporated to varying degrees as desired. problems and other related issues and problems, as well as various software to address some of the above. The software-based tools are useful for medical applications, including, but not limited to, stents, Other methods for displaying information related to blood vessels and two-dimensional and three-dimensional views thereof Other features and advantages of the disclosed embodiments are set forth in the accompanying drawings, which are incorporated herein by reference in their entirety. These points will become apparent from the following description and accompanying drawings.

[0012] The present disclosure relates to different aspects and embodiments and other features set forth and illustrated herein. However, each of the above disclosed herein may be used in whole or in part, as appropriate. It is understood that the present invention can be integrated together. Each embodiment incorporates each of the aspects to varying degrees as necessary for a given implementation. Additionally, the various stent expansion diagnostic tools described herein can be used with various imaging systems. It can be used with multiple modalities.

[0013] Other features and advantages of the disclosed embodiments will become apparent from the following description and accompanying drawings. It would be. [Brief explanation of the drawings]

[0014] [Figure 1A] 1 shows a schematic diagram of an imaging and data collection system according to aspects of the present disclosure. [Figure 1B] 1 illustrates an exemplary operational configuration of an embodiment according to aspects of the present disclosure. [Figure 2] 1 illustrates a diagram of synchronizing a subject's time-varying cardiac cycle data with angiographic images of the subject, according to aspects of the present disclosure. [Figure 3] 1 illustrates a diagram of synchronizing live and non-live data according to aspects of the present disclosure. [Figure 4A] 1 illustrates a diagram of correlating time-varying cardiac cycle signal data with angiographic images, according to aspects of the present disclosure. [Figure 4B] 1 illustrates a diagram of correlating time-varying cardiac cycle signal data with angiographic images, according to aspects of the present disclosure. [Figure 5] 1 illustrates live fluoroscopic images and live time-varying cardiac cycle signal data of a subject, according to aspects of the present disclosure. [Figure 6] 1 illustrates an illustration of real-time correlation between non-live and live data according to aspects of the present disclosure. [Figure 7] 1 illustrates the replacement of a live fluoroscopic image with a non-live angiographic image, according to aspects of the present disclosure. [Figure 8] 1 illustrates a live fluoroscopic image overlaid with markers, according to aspects of the present disclosure. [Figure 9] 1 shows a flow diagram of a method according to an aspect of the present disclosure. DETAILED DESCRIPTION OF THE INVENTION

[0015] In part, the present disclosure relates to measuring cardiovascular timing parameters and / or signals such as ECGs. and a pressure signal, such as the aortic pressure signal, to generate an angiographic frame corresponding to a portion of the cardiac cycle. SYSTEM AND METHOD FOR DISCRIMINATING SYSTOLE AND DIASTOLE Use the dicrotic notch and other timing indicators, such as those used to measure Furthermore, the disclosed systems and methods may be used to Based on real-time correlation with timing parameters, the angiogram corresponding to the current fluoroscopic image is Shadow frames can be identified.

[0016] In one embodiment, for each live fluoroscopy frame, a corresponding angiography frame are identified based on signal or timing parameter correlation, such as by ECG correlation. Additionally, in some embodiments, an intravascular probe marker, such as a radiopaque marker, is Used under contrast, optical coherence tomography (OCT) or as part of an intravascular imaging session. The first is intravascular ultrasound (IVUS) imaging. Intravascular imaging (such as OCT or IVUS) facilitates angiographic correlation.

[0017] OCT uses light to peer into the coronary artery walls and generate images of them for examination. Catheter-based imaging modalities include coherent light, interferometry, and micro-optics. Utilizing these components, OCT provides microscopic video-rate in vivo tomography of diseased blood vessels. Fiber optic probes can be used to measure subsurface structures with resolution up to 1000 kJ / s. High-resolution observation of tissues and organs is a key technology for minimally invasive imaging of internal tissues and organs. This level of detail made possible by OCT allows users to visualize coronary artery disease. This allows for the diagnosis as well as monitoring the progression of the disease. Intravascular ultrasound ("IVUS") imaging, which uses high-frequency sound waves to create images inside blood vessels. It is something that is created.

[0018] OCT / IVUS imaging of a patient's body parts is a useful diagnostic tool for physicians and others. For example, imaging of coronary arteries with intravascular OCT / IVUS can reveal narrowing or This information can reveal the location of the stenosis, allowing cardiologists to perform invasive coronary biliary Pathological procedures and minimally invasive catheters such as angioplasty or stent delivery It helps to choose between the standard procedure and the standard treatment. However, stent delivery has its own associated risks.

[0019] In one embodiment, co-registration of angiography and live fluoroscopy is combined with the above. Intravascular markers and intravascular image data or parameters can be overlaid with live fluoroscopy. Based on the collected endovascular data set, it may be possible to perform co-registration. Stent detection, stent expansion, side branches, and other image data detected by the three images As a result of the co-registration between the datasets, live fluoroscopic and angiographic images are linked. or may be displayed against them.

[0020] These various datasets, angiography, intravascular imaging (OCT / IVUS), and radiology Eve fluoroscopy can be combined, interlaced, used, juxtaposed, or may be integrated to present combined or joint registration data to the end user. Furthermore, in various embodiments, the present disclosure provides angiography frames interfacing with live fluoroscopy. The present invention relates to a method for reducing the amount of contrast agent solution used by performing a lacing operation, thereby Fewer angiographic frames are used and less contrast solution is required.

[0021] Angiographic images, fluoroscopic data, and intravascular data are used to support cardiovascular diagnosis and stenosis treatment. The use of MRI, as well as other imaging modalities, has led to expedited timeframes. When feasible, end-user assistance is extremely valuable. Addressing the various competing obstacles to achieving this goal presents a significant technical challenge. Use of co-registered data and signals such as KG, systolic transition, diastolic transition, etc. subsets and having a stored, historical, or otherwise non-live subset of frames Various interlaced, static, interlaced and mixed data streams are included. and generation of a fused dataset. do.

[0022] In part, the present disclosure relates to fusing angiographic co-registered images and / or data with live fluoroscopy. Additionally, the present disclosure relates to angiographic co-registration (co-reg) systems and methods. A system for combining registration (reg) information with one or more live fluoroscopy feeds. The present invention relates to a system and method.

[0023] 1A and 1B illustrate arteries, stents, and other cardiac Visualize vascular components and visualize live data with angiographic and intravascular data. Overview of imaging and data acquisition systems suitable for synchronizing with data acquired during registration. In one embodiment, the fluoroscopic feed is The images are acquired from a C-arm or other fluoroscopic imaging device or system. In some embodiments, the disclosed imaging systems, devices, and subsystems are used in cath labs. This is suitable for use in OCT / IVUS angiography co-registration systems. Provides direct guidance to physicians placing stents and devices in defined locations do.

[0024] The systems and methods disclosed herein allow physicians and other cath lab personnel to perform various procedures. It solves various technical problems that need to be addressed during installation. For example, 27, 82 or other displays on one screen, such as an angiography screen. The physicians working on the stent planning may be pushing the stent forward at the same time and far away. I looked at another screen 133 and tried to piece this information together in my head while watching the live Relaying fluoroscopic data is very burdensome. Other data, e.g., intravascular data or If pressure data is provided on different screens, the user's stress and mental The burden on the patient increases even more. The user can then push the stent forward, determining where the stent will go and where it will be positioned in the desired geometry. You need to plan in your mind how to orient yourself to an academic landing zone. This is done by periodically puffing or injecting a contrast solution to visualize the arteries. It is difficult to apply a dark contrast agent solution while pushing a dark object corresponding to the target. For example, visualizing the blood vessel, pushing the stent into the landing zone, contrast media The blood is forced into the solution, for example, as part of guiding the stent to the target zone near the side branch. It is very difficult to see the entire vessel. In addition to the above, angiography, fluoroscopy, and intravascular Having to move your head back and forth between different screens that may be far away from each other is a very difficult thing to sustain.

[0025] Furthermore, tortuous arteries have undulating branches that move in three dimensions, so the reference frame As a result, losing track of the target lane can be difficult. Geographical errors relative to the binding zone can occur. However, if you have kidney problems, you can continue to puff / push to compensate. Depending on various conditions, such as the stenosis, it is not recommended to use a large amount of contrast medium. or an under-expanded stent needs to be re-expanded with a balloon. The more complex the stent planning, the more complex the factors. It offers many advantages.

[0026] types of angiography systems that use OCT, IVUS, or other intravascular imaging systems Each data acquisition and diagnostic system uses a radiopaque mask to track a given probe. Considering that an imaging probe with a focuser is used, the angiographic data Both of these datasets can be co-registered with the aortic pressure data. The pressure signal or other pressure signals, EKG signals, dicrotic signals and field signals used to monitor and other timing signals to co-register, correlate, or interrogate with a live fluoroscopy feed. A dongle or other data transmitter such as that shown in Figure 2 can Transmitting pressure data on a given data acquisition device, such as an imaging system or pressure sensing system The pressure transducer from the subject can be connected to the intravascular imaging system wirelessly or by a wired connection. relaying pressure data applied to the stem and synchronizing the angiography data with the pressure data; Such data can be stored for use in the cath lab. Synchronization with angiography data The aforementioned processing of the collected pressure data may include other pressure signals, EKG signals, dicrotic signals and location, Other timing signals, frames of intravascular data, pressure data, flow data, and catheter This can also be achieved using other data collected in the live It can be shown on the fluoroscopic data.

[0027] In one embodiment, approximately K frames per second of angiographic data are obtained by A given curve, such as a curve or an ECG curve, is divided into K / n slices. In an embodiment, K is about 15. For a given angiography frame or OCT / IVUS frame, For each model, angiographic or OCT / IVUS data are plotted on a given AO plot, E CG plots, systolic plots, diastolic plots, or other time-varying functions suitable for co-registration Co-registration can be performed for bins, periods, slices, or time slices. In one embodiment, a given time-varying plot / function, such as an AO curve or an ECG plot, is The data is divided into K bins, for example 15 bins. As a result, the co-registration system Which frame corresponds to the first part of the cardiac cycle and which frame corresponds to the identified dicrotic notch or track or otherwise map which part of the frame corresponds to mid-diastole, etc. Thus, a given curve or plot can be divided into bins, subsets, slides, and so on. and maps the images onto frames of angiographic and / or intravascular and / or fluoroscopic data. In one embodiment, greater stability results from: AO pressure near the aortic notch may be preferred.

[0028] Each cardiac cycle is approximately 1 second. Furthermore, a typical angiographic imaging system measures approximately 15 cardiac cycles per second. In one embodiment, there are approximately 15 frames per cardiac cycle. In one embodiment, there are approximately 30 frames per cardiac cycle. It includes components for sampling K frames per cardiac cycle. The sampled data may be smoothed or filtered.

[0029] In one embodiment, a given cath lab data collection system and method embodiment There is a live fluoroscopy feed for each patient. Other timed data such as AO pressure data or ECG may also be available. The signal data is used to determine which portion of the cardiac cycle corresponds to a given AO pressure data. This is used to measure the systolic and diastolic phases of the cardiac cycle, or other phases relative to the cardiac cycle. This may correspond to identifying a traceable period of AO pressure data or other timing data. The data or signals are mapped to the cardiac cycle or other clock or timing subsystem. Once scanned, the subject data is then co-registered with the OCT / IVUS markers. Generally, the system and method are Which portion tracks or is associated with a particular frame of image data or other parameter of interest? Identify which corresponds to which.

[0030] The above is useful for co-registering live fluoroscopic data. Specifically, AO pressure data over time with respect to other data or signals, such as ECG data for fluoroscopic data Real-time correlation is used to effectively identify the portions of the cardiac cycle that can be tracked. , which selects any frame from the set of angiographic image frames and takes This facilitates replacing the frame with a live perspective frame. Substitution or picture-in-a-picture representations may also be used. In one embodiment, a transformation or other method is used to combine an angiography frame with a fluoroscopy frame. Various interlacing techniques can be used. Frame Swap uses a library of images from a previously generated angiogram using contrast media. Supports the use of

[0031] If you have knowledge of the time position of the image from the fluoroscopy in relation to the cardiac cycle, you can Interlacing a library of automatically generated angiography frames with live frames In this way, new angiography frames are not required to the same extent. The amount of contrast solution used can be reduced by not using the live fluoroscopy feed. Interlacing with a library of acquired angiographic frames at different time points is performed automatically. It is possible to do so.

[0032] These coregistrations based on cardiac cycle and other timing correlations have a number of advantages. For example, if flashing was used in a previously acquired angiography frame, Effectively simulating contrast flushing with libraries available or by using intravascular data such as OCT or IVUS image data. By doing so, the stent can be pushed into the vascular system and deployed. The system and method facilitates reducing contrast solution exposure and allows for the use of intravascular image data. By using a contrast agent solution, the need for contrast agents can be eliminated or at least greatly reduced. In various embodiments, the angle / position of the imaging device for fluoroscopy can be changed. Additionally, this can help reduce the need for contrast solutions.

[0033] In one embodiment, during intravascular pullback, the image frame is darkened under angiography. There is a separate period of pullback, which is tracked and indexed relative to the angiography frame. can be customized to match AO pressure data, ECG data, dicrotic notch, or other timing data. In one embodiment, subsequent interlaces of a frame All of these can be performed using AO data or other timing data. Use the display to pull frames from the live feed and capture angiography frames. using a frame grabber that interlaces with or combines with intravascular data. In practice, live fluoroscopic data is shown and then the vessels are Swap non-live angiogram data from a library of contrast frames, etc. Intravascular imaging markers such as OCT / IVUS markers and other information can be displayed in the live fluoroscopy frame. It may be combined with, overlaid on, or otherwise used with a feed. In this way, various types of image data can be fused or combined with live fluoroscopic data. This allows for accurate positioning of the stent landing zone, and various other outcomes. can support.

[0034] These and other techniques disclosed herein may also be used to perform atherectomy. The scan is guided to measure calcium and other The detection elements can include guidewires, stenoses, and other elements that can be detected using intravascular data. nt, side branch, lumen, MLA, lumen diameter, lumen profile, area, cross section, volume, malapposition Malapposition, under-expanded stents, jailed side branches, and other information The systems and methods disclosed herein can be used to co-register with live fluoroscopy. do.

[0035] FIG. 1A illustrates a method for collecting data or detecting characteristics of a subject 4 or assessing a condition of a subject 4. Various data collection services suitable for detecting conditions or otherwise diagnosing the subject 4. In one embodiment, the subject is seated on a table, a bed, The device is placed on a suitable support 19, such as a desk, a chair, or other suitable support. Specifically, the subject 4 is a human or another animal having a particular region of interest 25 .

[0036] The data acquisition system 5 may be a nuclear magnetic resonance, X-ray, computer-assisted tomography, or other suitable This includes non-invasive imaging systems, such as appropriate non-invasive imaging techniques. As one non-limiting example of a system, angiography suitable for generating cine is shown. Shown is an angiography system 21. The angiography system 21 may include a fluoroscopy system. The angiography system 21 may be configured to perform imaging in one or more imaging techniques, such as OCT or IVUS. The probe 30 is configured to image blood vessels within the region 25 of the subject 4 using angiography. blood flow, typically in the form of frames of image data, while a pullback procedure is performed using configured to non-invasively image a subject 4 so as to generate frames of angiographic data. It is done.

[0037] Angiography system 21 is in communication with an angiography data storage and image management system 22. In one embodiment, the angiography data storage and image management system 22 is In one embodiment, the collected data can be implemented as a station or a server. The data processing associated with the acquired angiographic signals is performed directly on the detector of the angiography system 21. Images from the system 21 are stored by angiography data storage and image management 22. Will other imaging systems disclosed herein replace system 21? Or the system 21 can be augmented.

[0038] Imaging data, such as vascular representations, and data derived therefrom, can rapidly provide diagnostic information. These are generated and displayed as part of the user interface to allow the user to visualize the different lumens. Profiles and values ​​at corresponding positions along their length, such as area, diameter, etc. It can take the form of a ratio of geometric values ​​of

[0039] The system in Figure 1A supports CT scans, ultrasound, IVUS, and X-ray-based imaging modalities. , magnetic resonance imaging, optical coherence tomography, infrared-based imaging, laser-based imaging, and one or more of the other imaging modalities for intravascular and extravascular imaging. and various imaging devices for imaging one or more arteries and / or components of the cardiovascular system. In one embodiment, the system server 50 and / or workstation Station 85 may handle the functions of system 22. In one embodiment, The entire system 5 generates electromagnetic radiation, such as x-rays. The system 22 also transmits radiation through the subject 4. The data processing system 22 receives such radiation after it has passed through the angiography system. Signals from the stem 21 are used to image one or more regions of the subject 4, including the region 25. do.

[0040] The region of interest 25 may be a subset of the vasculature, such as a particular blood vessel, or the peripheral vasculature. This subset includes OCT, ultrasound (alone or in combination), or other imaging modalities as described herein. It can be imaged using one of the other imaging modalities disclosed. In some embodiments, the region of interest may include a stent or a region where a stent is to be placed. The stent can be imaged at different times, such as after deployment and after additional stent expansion. This can be done.

[0041] A catheter-based data collection probe 30 is introduced into the subject 4, e.g., into the coronary arteries. A probe or other device containing a balloon is placed in the lumen of a particular blood vessel, such as a In response to detecting insufficient expansion of the stent using one or more imaging modalities , can also be used to increase the level of stent expansion.

[0042] The probe 30 may be, for example, an OCT probe, an FFR probe, an IVUS probe, or the above-mentioned and other probes suitable for intravascular imaging. The probes can be of various types of data collection probes, such as: In one embodiment, a balloon delivery device is described herein. The imaging probe shown is moved along the guidewire used for the imaging probe. In configuration, the probe 30 typically includes one or more radiopaque probe tips. The probe tip includes a light beam, a fiber optic, and a torque wire. directors, acoustic beam directors, pressure detector sensors, other transducers or detectors, and It includes one or more data collection subsystems, such as a combination of the above.

[0043] In the case of a probe including an optical beam director, the optical fiber 33 is The torque wire defines a hole through which the optical fiber is disposed. In Figure 1A, optical fiber 33 is shown without the torque wire surrounding it. Additionally, the probe 30 also includes a polymer sheath (not shown) that forms part of the catheter. In the context of an OCT system, the sample artefact of the interferometer may include a sheath. The optical fiber 33, which is part of the system, is connected to the patient interface unit (PMI) as shown. The patient interface unit (IU) 35 is optically coupled to the patient interface unit (IU) 35.

[0044] The patient interface unit 35 receives the end of the probe 30 and is optically coupled thereto. Typically, the data collection probe 30 is used The PIU35 is suitable for use based on the type of data collection probe used. Includes appropriate joints and elements, e.g., OCT and IVUS data collection probe combinations. The alignment requires OCT and IVUS PIU. PIU 35 typically uses torque The wire, sheath, and optical fiber 33 disposed therein are pulled back as part of the pullback procedure. In addition to being retracted, the probe tip also includes a motor suitable for retracting the probe tip. In this way, the blood vessel of the subject 4 is rotated longitudinally by the PIU 35. The probe 30 can also image fractional flow reserve (F Measure specific parameters such as fractional flow reserve (FR) or other pressure measurements can be used for

[0045] The PIU 35 is then connected to one or more intravascular data acquisition systems 42. The data acquisition system 42 may be an OCT system, an IVUS system, or another imaging system. , and combinations thereof. For example, probe 3, which is an OCT probe. The system 42 in the context of 0 includes a sample arm of an interferometer, a reference arm of an interferometer (refer The patient interface unit includes a patient control arm, a photodiode, a control system, and a patient interface unit. Similarly, as another example, in the context of an IVUS system, intravascular data The data acquisition system 42 includes ultrasonic signal generation and processing circuitry, noise filters, a rotatable jaw, In one embodiment, the device may include a power point, a motor, and an interface unit. The data acquisition system 42 and the angiography system 21 are connected to an angiography video frame time. and a co-located OCT image frame timestamp. It may have a clock or other timing signal.

[0046] Various extravascular imaging systems, such as angiography systems, can visualize various expanded states of stents, etc. A given region of interest can be imaged. The extravascular imaging data can be combined with the intravascular imaging data. The output of the intravascular and extravascular imaging modalities is shown in Figure 1B. Graphical user interfaces 127 on various displays 123 are used to This can be displayed to the patient in the telab.

[0047] In addition to the invasive and non-invasive image data collection systems and devices of FIG. 1A, regions of a subject 25 and other parameters of interest for the subject. For example, the data collection probe 30 may be connected to, for example, the pressure wire 23 shown in FIG. The pressure wires may include one or more pressure sensors, such as an OCT or ultrasound sensor. It can be used with or without the addition of components. It can be acquired along a segment of a blood vessel within the region 25 of the examiner 4 .

[0048] Such readings may be relayed by a wired connection or via a wireless connection. As shown in the fractional flow reserve FFR data collection system, the wireless transceiver 48 Receives pressure readings from the probe 30 and transmits them to the system to measure It can be configured to generate FFR measurements at one or more locations along a blood vessel. One or more displays 82, 83, 123 of FIGS. 1A and 1B may also display an angiographic view of the data. Frames, OCT frames, user interfaces for OCT and angiography data, and other controls and features of interest.

[0049] As shown in FIG. 1A, a flow of intravascular data generated using a data collection probe 30 Intravascular image data such as rhein is collected by a data collection and processing unit connected to the probe via PIU35. The angiography system 22 may route the image data generated using the angiography system 22 to the angiography system 42. The non-invasive image data is then transmitted to one or more servers, such as a co-registration server 50 and a workstation 85. to a server or workstation, where it may be stored and processed. a computer configured to capture angiographic image data from the system 22; A video frame grabber device 55, such as a video frame grabber board, may be used in various embodiments. do.

[0050] In one embodiment, the server 50 is stored in a memory 70 and operated by a processor 80. The server 50 includes one or more co-registration software modules 67 executed by Includes other typical components for a processor-based computing server. Alternatively, a database such as database 90 can be used to store the generated image data. data, subject parameters, and one or more of the system devices or components shown in Figure 1 generated by the user and received by or transferred to the database 90 The database 90 may be configured to receive other information transmitted to it. The data is stored in the memory of the workstation 85 while connected to the server 50. Although this is shown, this is only one exemplary configuration. For example, software module 6 7 can run on the processor of a workstation 85 and the database 90 The various software modules may be located in the memory of the server 50. The devices or systems used to perform the In this case, the hardware and software described herein are Acquire, process, and use such image data to describe the image data It is possible.

[0051] Unless otherwise stated herein, software module 67 is a preprocessing software. software, transformations, matrices, and other software-based components 67, which allows the processing of different types of image data by other software-based components. To facilitate or otherwise effect joint registration of data other software used to process image data or respond to patient triggers. The module can include scanline-based components. or lumen detection using image-based techniques, scanline-based or image-based techniques Stent detection, indicator generation, stent expansion evaluation and assessment using ation and assessment), stent landing zone detection, and indication of deployed stent Markers, co-registration of angiographic and intravascular imaging, and performing the methods disclosed herein The system may include other modules that support and are programmed to do so.

[0052] The database 90 is generated by the angiography system 21 and is stored in the frame grabber 55 sub-system. The image data 92 is received and stored in the memory 90. The database 90 can be configured as follows: The frame grabber 55 receives OCT / IVUS images such as image data acquired by the server 50. The image data 95 can be configured to be received and stored.

[0053] Additionally, the subject 4 may be connected to one or more monitors, such as monitor 49, via one or more electrodes. The monitor 49 may be electrically coupled to a cardiac monitor, such as, but not limited to, a monitor relating to cardiac function. an electrocardiogram configured to generate data indicative of various states of the subject, such as systole and diastole; The cardiac geometry, including the coronary arteries, can be monitored even during different cardiac cycles. Even over a period of time, the mental phase is almost the same at a certain mental phase. Therefore, knowing the mental phase is It can be used to assist in tracking vascular central lines.

[0054] The use of directional arrows, or lack thereof, in a given diagram indicates how information can flow. It is not intended to limit or require any particular orientation. For example, the elements shown in Figure 1A may be connected in any particular order. For a given connector, such as an arrow or line shown in The connection can be in one or more directions or in only one direction, as appropriate. Any suitable data transmission connection, such as an optical connection, a wired connection, a power connection, a wireless connection, or an electrical connection may include:

[0055] One or more software modules may be used in conjunction with an angiography system, such as system 21 shown in FIG. 1A. It can be used to process frames of angiographic data received from the system. Without limiting the scope of the Software, its components, or any software-based or various software programs that may include one or more steps of a processor-implemented method. A module may be used in any given embodiment of the present disclosure.

[0056] The system of Figures 1A and 1B is suitable for displaying intravascular and extravascular image data. In particular, the system includes a stent planning and stent expansion assessment and target stent expansion. In one embodiment, the stent expansion threshold is determined by the OC Provided by a diagnostic system such as T, IVUS, or other image data acquisition system or such thresholds can be adjusted by the end user via a user interface. In one embodiment, areas of insufficient expansion of the stent can be identified. The stent expansion threshold used to distinguish between the two ranges from about 80% to about 90%. When the tent inflates to a level of 48% at the first location along its length, it while in another area, the stent is tagged or represented with a visual cue or marking of If it extends to a level of or beyond, it is indicated by another visual cue or sign. be identified.

[0057] Figure 1B shows the results of OCT, FFR, IVUS, angiography, and C for one or more arteries in a patient. Figure 1A for performing T-scans or other types of imaging, measurements, and assessments Catheter lab set having components of an imaging and data acquisition system such as the system of A user may interact with or otherwise use the data collection system. The stored image data can be accessed and displayed through various displays shown in FIG. Intravascular imaging data and stent expansion data co-registered with angiography data can be used. An exemplary user interface showing the data is displayed. The support member 115 can be a table, a base, or the like. The support member 115 may be an accessory rail on a support rod or other support 120. 120, and the controller may be part of the support 12 It can be attached directly to 0.

[0058] In one embodiment, the controller may include any suitable input device. The user interface screen and the target stent expansion value and other stent expansion thresholds are displayed. It can be used to navigate through parameters such as values. A graphical user interface displayed on the monitor or display 123. In one embodiment, the monitor The graphical user interface can be mounted on a ceiling suspension. The user interface 127 can be displayed on a given monitor. The user interface provides stent expansion as well as co-registered endovascular data, e.g. This may include CT / IVUS data, angiography data, and fluoroscopic image data.

[0059] In one embodiment, the controller includes a graphical user interface 127 configured to map to commands and menus available to the user as part of The angiography system or other imaging system disclosed herein has a set of functions. 125 may be used to monitor a patient's X-ray while another data collection procedure, such as an OCT / IVUS procedure, is in progress. The line can be positioned relative to the support 120. The user interface 127 is capable of handling such OCT, angiography, FFR, IVUS, and other imaging applications. The controller can display the data to the user through the interface 127. configured to control and navigate the menu and image display functions presented to the user Co-registration of angiographic data with intravascular imaging allows assessment of the level of stent expansion. Second, fluoroscopy can be co-registered with angiography and intravascular imaging. This improves stent deployment and facilitates arterial-directed treatments such as stent placement, atherectomy, and angioplasty. This means that patients only need to look at one display during treatment.

[0060] The present disclosure provides a method for delineating areas of underexpansion of a stent and generating a stent image using intravascular data. At the target dilation level for the vessel representation, the target balloon for the implanted stent is Systems and methods are described that facilitate implant placement and sizing. and other imaging modalities, as shown and described herein, produce a variety of vascular representations. Various image data processing techniques are also performed to identify the lumen L, stent struts SS, Can be used to detect and / or visually represent side branches SB, and others .

[0061] These systems, devices, and methods may be used in conjunction with one or more diagnostic imaging modalities, such as cardiac imaging modalities. These imaging modalities are implemented when a subject is first evaluated using the method. These include, but are not limited to, OCT, IVUS, computer-assisted tomography, MRI, and angiography. Shadows, x-rays, cardiac and / or vasopressor operation and status data It can include a data-based model.

[0062] FIG. 2 shows a graph of the luminescence intensity of a sample collected from area 25 of patient 4 using the system described in FIGS. 1A and 1B. The angiographic data synchronized with the time-varying parameters of the patient's cardiac system, e.g. For example, an angiogram image 210 is shown. The collected cardiac data may be ECG data or pulse data. The pressure is picked up by the pressure wires 232 in the lobes 30 and transmitted to the wireless transceiver 48. The AO pressure data 220 may include AO pressure data 220 transmitted to a collection device 240. The AO pressure data 220 may include , which are time-varying parameters that can be synchronized with the angiographic data acquired from the patient. For example, The angiographic image 210 includes AO pressure data 2 corresponding to the time the angiographic image 210 was captured. By determining the part of 20, it can be synchronized with the part of AO data 220. This process can be performed on multiple angiograms, resulting in a The angiographic image is based on the time at which both the angiographic image and the AO pressure data 220 were acquired. , correlated with a particular portion of the patient's AO pressure data 220.

[0063] In FIG. 3, intravascular (OCT / IVUS) and angiography data 310 are acquired and Similar to the synchronization described in relation to Figure 2, co-registered intravascular / hemorrhagic The angiographic data 310 is synchronized to the AO data 220 so that a particular angiographic The image and the OCT / IVUS image are correlated with a specific portion of the AO data 220. The collected intravascular / angiographic data 310 and AO data 220 are shown in FIGS. 1A and 1B. In addition, the systems of FIGS. 1A and 1B may be stored in one or more storage devices. The system can acquire live fluoroscopic images 312 from the patient. These live fluoroscopic images 312 can be synchronized with live AO data 320. As an example, Although the synchronization described herein is used, it is possible to synchronize live and initial images, including ECG data. It can be performed with any recurring time-varying data acquired during the co-registration stage. The live AO data 320 is then compared and synchronized with the previously acquired AO data 220. The live fluoroscopic data 312 can then be used to generate an intravascular endovascular image based on this comparison. The contrast data 310 can be synchronized or co-registered. identifying corresponding fluoroscopic and angiographic images associated with a particular subset of the patient's cardiac cycle; It is possible.

[0064] In various embodiments, the ECG and AO pressure signals are used to measure the vascular pressure corresponding to each portion of the cardiac cycle. As shown in Figure 4A, the ECG pulse 424 is used to identify the contrast frame. , can be identified in the patient's ECG signal 414, while the AO pressure rise 422 and The dicrotic notch 423 can be identified in the patient's AO pressure signal 412. The ECG signal 414 and AO pressure signal 412 acquired during the imaging and angiography are taken. As mentioned above, the initial image data set of the intravascular angiography image is synchronized. Co-register the ECG and AO pressure signals acquired during co-registration with the live ECG and AO pressure signals. The live fluoroscopic image is then synchronized with the initially co-registered intravascular and angiographic images. The grid of vertical lines 430 in FIG. 4B can be synchronized with the ECG signal 414 and A 412, which corresponds to a time slice or bin of the cardiac cycle associated with a portion of the O signal 412. These are all correlated to specific angiographic image frames 442-448. Shadow image frame 442 shows the AO pressure signal 412 increasing from a signal minimum to a signal maximum. Therefore, the angiographic image frame 442 is acquired during the period when the A 0 is identified as being associated with this portion of the pressure signal 412. 44 and 446 are the start and end periods of the dicrotic notch in the AO pressure signal 412, respectively. Similarly, angiographic image frames acquired during the ECG pulse. The program 448 is associated with a corresponding period represented in the ECG signal 414. The process involves analysing the data so that each intravascular angiographic image is correlated to a specific period within the patient's cardiac cycle. It can be performed on all acquired intravascular and angiographic images.

[0065] FIG. 4B shows a single cardiac cycle decomposed into a series of time slices, but with multiple Similar divisions can be made relative to the cardiac cycle. In addition, the number of time slices can be varied. For example, the system illustrated in Figures 1A and 1B may be used to It may be configured to capture OCT / IVUS images and angiography images, The frame rate may be configured by the user. For example, the disclosed system Acquires angiographic images at either 15 frames per second or 30 frames per second Similarly, the disclosed system may be configured by the user to The pressure signal can be configured to be divided into time slices of various durations. The ECG and AO pressure signals are divided into 30 time slices per second, and the angiographic images are recorded at 3 times per second. If the time slice is 0 frames, the system will capture one angiogram image for each time slice. The ECG and AO pressure signals can be configured to be correlated at 15 time intervals per second. If the angiogram is divided into slices and the angiogram is acquired at a rate of 30 images per second, A number of angiographic images can be assigned to a particular time slice. If the number of devices is greater than the number of angiograms acquired during a given period, some time devices may be Only the Rice is correlated with the angiographic image. As mentioned above, the angiographic frame is The location of the markers in the images and the timing system used between the two imaging modalities Based on this, the image may be co-registered with simultaneously acquired OCT or other intravascular images.

[0066] The angiographic image is correlated to a particular portion or time slice of the patient's cardiac cycle data. The disclosed system and method provides real-time correlation with live ECG and AO signals. Based on this, an angiography image frame corresponding to the live fluoroscopic image can be identified. For example, FIG. 5 shows a live fluoroscopic image 510 and live ECG and AO pressure signals 520. The live fluoroscopic image 510 is taken at time 522 and includes an ECG and This live ECG and AO pressure signal 520 is correlated with a specific set of AO pressure signals. The ECG and AO signals are also correlated with previously acquired ECG and AO signals to generate live fluoroscopic images 510 and Correlation and co-registration with a library of previously acquired OCT / IVUS and angiographic images For example, the disclosed system can support ECG and AO pressure data. 5. The fluoroscopic image 510 is determined based on a live fluoroscopic image 512 taken previously during the same portion of the patient's cardiac cycle. The disclosed system may identify one or more embedded angiographic images. , track ECG and AO signals in live fluoroscopic images, and record previously captured intravascular and blood vessel images. The corresponding ECG and AO signals in the angiographic image can be identified.

[0067] For example, time slice 430 of ECG signal 414 and AO signal 412 shown in FIG. can be correlated with the ECG and AO signals 520 shown in FIG. As such, a time slice 630 of the ECG and AO pressure signal 420 is The ECG and AO signals at time 522 represent the portion of the patient's cardiac cycle in which the pulse occurs. The system disclosed herein is thus determined to correspond to the angiographic Determine that the shadow image 448 corresponds to the same part of the patient's cardiac cycle as the live fluoroscopic image 510. Based on this identified correlation with the previously acquired ECG and AO pressure signals 420, The live ECG and AO signals 520 are then compared to the previously captured OCT and angiography image data. It can serve as a timing signal onto which non-live data, including Therefore, the angiographic images 442-448 for different time slices are obtained by live E The CG and AO signals 520 can be correlated to corresponding portions of the signal.

[0068] Based on the correlation of the non-live and live signals described above, the angiographic image frames are lined. In combination with fluoroscopy, the amount of contrast agent solution used can be reduced. A series of live fluoroscopic image frames 702, 704, and 706 are shown, The image frame 704 is replaced in real time with an angiographic image frame 710. As such, the disclosed system generates angiographic image frames based on the patient's cardiac signals. 710 corresponds to the same portion of the patient's cardiac cycle as live fluoroscopic image frame 704. In this way, the physician can visualize angiographic and fluoroscopic images in a single sequence of image frames. In this way, the physician can view both the previously captured angiogram image and the By using the reference, the location of various devices and stents in the live fluoroscopic image can be determined. FIG. 7 shows that the fluoroscopic image 704 is compared with the angiographic image 71. 0 indicates that the interlacing of the angiogram image is replaced by the live fluoroscopy image. This may be done without removing image frames, e.g., by recomposing at a higher frame rate. One or more angiographic image frames are inserted into the live fluoroscopy to present the combined frame. Alternatively, one or more live fluoroscopic image frames may be inserted between the fluoroscopic image frames. The image frame may be replaced by one or more corresponding angiographic image frames. The system allows the user to select the number of consecutive fluoroscopic and angiographic images to be displayed. For example, the user may be able to select whether the system should display a series of three live fluoroscopic images. Configure the system to present two consecutive angiographic image frames following a frame. Alternatively, the user may configure the system to display one angiographic image in each series of four live fluoroscopic images. The user may also configure the system to display sequential fluoroscopic and angiographic images. The frame rate at which the images are shown may be configured. In this way, the user can The manner in which the visual and non-live angiographic image sequences are displayed can be controlled.

[0069] Additionally, the non-live image data may be converted into live fluoroscopic images in accordance with aspects of the present disclosure described above. For example, FIG. 7B shows stent planning markers 812, A live fluoroscopic image is displayed with 814 and 816 overlaid on the fluoroscopic image. These stent planning markers 812-816 are shown in a series of angiograms. The image may be based on markers placed within the image. The various arteries within the heart move as the patient's cardiac cycle progresses. Therefore, the relative locations of these markers may shift from one angiographic image to another. However, both the angiographic and fluoroscopic images are correlated to the patient's cardiac cycle. By doing so, the stent planning markers 812 and 814 indicate the location of the artery where the stent is to be placed. can be overlaid on each perspective image in a way that maintains their proper position relative to the Therefore, the system can extract the stem from the OCT angiography image on the live fluoroscopy feed. These markers and other markings are used by physicians to provide more accurate placement of OC planning markers. Geographical mismatches can be avoided by ensuring that the areas planned to be addressed are targeted. Other useful endovascular data includes data obtained from IVUS images. Angiographic data can also be overlaid on fluoroscopic images, but is not limited to this. do not have.

[0070] Flow diagram 900 of FIG. 9 illustrates how the system shown in FIGS. 1A and 1B interacts with a user. provides an example that can provide a display of sourced non-live and live images, where: The images are presented sequentially, with both live and non-live images corresponding to the patient's cardiac cycle. Although the operational blocks of FIG. 9 are provided in a particular order, they may be implemented in one or more of the disclosed systems. The processor may add operations, delete operations, or The order of the operations can be switched. The system may generate a first set of images and a first set of time-varying cardiac cycle data. As described above, the first set of images may be OCT images. Or it may include angiographic images along with co-registered intravascular images such as IVUS images. The eccentric cardiac cycle data may be data representing an ECG signal, AO pressure data, or data relating to the patient's cardiac cycle. These may include other time-varying data that are captured in the first set of images. In block 904, the first set of images collected is The correlation is performed on a specific subset of the time-varying data in the dataset. An example of this correlation is shown in Figure 4B. The angiographic images are then compared to the ECG and AO signals based on the period during which the angiographic images were acquired. Correlation of collected images with time-varying data involves: A method for identifying relationships between a particular image and a particular subset of time-varying data. Storing the variable data on a computer storage medium may be included. Each image from the block can be correlated with a specific portion of the patient's cardiac cycle. At step 906, a second set of images is acquired along with a subsequent set of time-varying cardiac cycle data. As mentioned above, the second set of images is collected along with the patient's live cardiac cycle data. This subsequent image may be a live fluoroscopic image, as provided in block 908. A set of live cardiac cycle data can be correlated with a first set of time-varying cardiac cycle data. can.

[0071] As mentioned above, a patient's cardiac cycle may follow a repetitive pattern, e.g., repeated pressure rises, dicrotic notches, These features of the live cardiac cycle data include the time, frequency, and ECG pulses. According to the system and method, the first set of cardiac cycle data can be correlated or matched. In block 910, the system generates a second set of one or more images of similar time-varying cardiac period. Identify one or more images in the first set that correspond to the period data. To compare live ECG and AO pressure data with non-live ECG and AO pressure data, By doing so, the system can visualize the patient's cardiac cycle at a similar time period to the live fluoroscopic image 510. The corresponding angiographic image 448 and the co-registered intravascular image can be identified.

[0072] Returning to flow diagram 900, the system then performs a second test that also corresponds to the same portion of the patient's cardiac cycle. An image containing one or more images from a first set interlaced with an image from a second set For example, live fluoroscopic images can be displayed in a sequence similar to non-live angiographic images. As mentioned above, interlacing of non-live images can be achieved by: This may include replacing one or more live fluoroscopic images with non-live angiographic images, Here, the replaced live fluoroscopic image and the selected non-live angiographic image are respectively: These are images captured during similar or corresponding portions of the patient's cardiac cycle. The interlace also identifies similar cardiac cycles of the patient based on the identification made in block 910. Instead of replacing the live fluoroscopic images captured during the segment, one or more non-radiographic images are The angiographic image may also be inserted into a live fluoroscopic image. By displaying the corresponding angiographic image as a picture-in-picture within the display of It can also be interlaced with live fluoroscopic images. In addition, the interlaced vessels The display of contrast-enhanced images includes blood images such as OCT or IVUS images co-registered with angiographic images. The co-registered intravascular frame may include an angiographic image and a fluoroscopic image. The images may be displayed on the same monitor or on a different monitor, and may be displayed in fluoroscopic and angiographic images. As provided in block 914, Thus, the system can determine whether the patient imaging session should continue. If so, the system can return to block 906 and add additional images of the second type. Images are acquired along with an additional set of time-varying cardiac cycle data. If input is received indicating completion, the process may end.

[0073] Non-limiting software for performing live fluoroscopy combined with other data such as image data Software Features and Embodiments In part, this disclosure provides a computer-aided visualization system for visualizing data against live fluoroscopic data. In one embodiment, the present disclosure relates to a database method, system, and device. By using pre-computed angiographic images that are interlaced with the live fluoroscopic images, Image segmentation can be performed using various techniques such as AI or machine learning. It can be done.

[0074] These assessment methods include one or more views of the artery from angiographic or intravascular imaging. This may include displaying the image relative to one or more live fluoroscopic image frames. Fluoroscopy-based methods reduce geographic errors and facilitate better imaging and artery-directed treatment. In one embodiment, the method is performed automatically. Live Fluoroscopy Mode The inserted stent was planned from the OCT / IVUS angiography co-registration system and method. can be placed in designated landing zones.

[0075] The systems and methods disclosed herein compare the detected stroke with the detected lumen contour. Evaluating the stent, calculating the stent expansion, calculating the MSA, stent Measuring parameters and the expansion level of the stent at different frames along the artery The various steps described herein, such as showing the bell, as well as other steps disclosed herein, In addition, the system can perform the features and methods. Co-registration with the data to show stent expansion data against angiographic data In one embodiment, live fluoroscopic data is recorded when the probe is from one or more intravascular imaging pullback sessions pulled back through a section of artery frames of data from one or more angiographic data acquisition sessions and one or more co-registered signals, such as AO pressure, ECG signals, and others disclosed herein. It is interlaced with the recording timing signal.

[0076] The following description is directed to device hardware suitable for implementing the methods of the present disclosure described herein. It is intended to provide an overview of the software and other operating components. This description is not intended to limit the applicable environments or the scope of the present disclosure. Similarly, hardware and other operational components may be suitable as part of the above-described apparatus. The present disclosure can be applied to personal computers, multiprocessor systems, systems, microprocessor-based or programmable electronic devices, network PCs Other system configurations, including minicomputers, mainframe computers, etc. The present disclosure also provides a method for controlling communication between devices, such as within different rooms of a catheter or cath lab. Distributed computing is a system in which tasks are performed by remote processing devices linked through a network. It may also be implemented in a computing environment.

[0077] Some portions of the detailed description refer to operations on data bits within a computer memory. These algorithmic descriptions and representations are presented in terms of algorithms and symbolic representations. It can be used by anyone skilled in the computer and software related fields. In embodiments, an algorithm, as used herein generally, is a set of operations that lead to a desired result. It is considered to be a self-consistent sequence of operations. The operations performed as steps or otherwise described herein are not limited to the physical manipulation of physical quantities. It is an operation that requires manipulations. These quantities are usually stored, transferred, combined, transformed, compared, and other forms of electrical or magnetic signals that can be manipulated in other ways. take.

[0078] Unless otherwise specified, as will be apparent from the following discussion, the term "processing" is used throughout the description. "processing" or "computing" or "overlaying" ) or "searching" or "detecting" or "measuring" "calculating" or "comparing" or "generating" "generating" or "determining" or "displaying" etc. Any discussion utilizing the terminology of Boolean logic or other related sets of operations is computer Refers to the actions and processes of a system or electronic device, and refers to the physical (electronic) quantities in the registers and memory of a computer system or electronic device. manipulate data represented as electronic memory or registers or other such It may also be represented as a physical quantity in such information storage, transmission, or display devices. It is recognized that the data may be converted to other data.

[0079] The present disclosure also relates, in some embodiments, to apparatus for performing the operations herein. This equipment may be specially constructed for the required purpose, or The device is selectively activated or reconfigured by a computer program stored in the computer. The present invention may include a general-purpose computer implemented on a computer.

[0080] Embodiments of the present disclosure may include a processor (e.g., a microprocessor, a microcontroller, computer for use with a computer (such as a digital signal processor, a Data-programmed logic, programmable logic devices (e.g., field programmed with a programmable gate array (FPGA) or other programmable logic device For use with programmable logic, discrete components, and integrated circuits (e.g. any other device, including, for example, an application specific integrated circuit (ASIC), or any combination thereof The present invention can be embodied in many different forms, including but not limited to the following: In an exemplary embodiment of the present disclosure, an OCT or IVUS probe and a processor-based Some or all of the processing of data collected using the system may be performed by computer programs. It is implemented as a set of RAM instructions, which are then converted into a computer-executable form. The program is converted and stored in a computer readable medium, and the program is then controlled by the operating system. Thus, the query response and input data are Generate imaging data, detect lumen boundaries, detect stent struts, and measure vertical The distance is compared with a set threshold, and image comparison, signal processing, lumen detection, stent detection, and the detected Comparison of the stents and other features and embodiments described above in other ways. The program is converted into processor understandable instructions suitable for processing.

[0081] Computer program logic that implements all or part of the functionality described herein The work may be in source code form, computer executable form, and various intermediate forms (e.g., (including formats produced by an assembler, compiler, linker, or locator), but The source code may be embodied in various forms, including but not limited to the above. For use with various operating systems or operating environments Programming language (e.g., object code, assembly language, or Fortran) in a high-level language such as .an, C, C++, JAVA, or HTML Source code can include a set of computer program instructions implemented in a specific language. The source code can define and use various data structures and communication messages. may be in a computer-executable form (e.g., via an interpreter); source code (e.g., via a translator, assembler, or compiler) It can be converted into a computer-executable format.

[0082] Computer programs are stored in semiconductor memory devices (e.g., RAM, ROM, PRO M, EEPROM, or flash programmable RAM), magnetic memory devices (e.g. diskette or fixed disk), optical memory devices (e.g., CD-ROM), P Tangible storage media such as C cards (e.g., PCMCIA cards) or other memory devices in any form (e.g., source code form, computer executable form, or intermediate form) Computer programs can be fixed permanently or temporarily in various communication technologies. The signal may be fixed in any form to a signal that can be transmitted to a computer using any of the techniques These communication technologies include analog technology, digital technology, optical technology, and wireless technology. technologies (e.g., Bluetooth), networking technologies, and Internetworking This includes, but is in no way limited to, computer programs. The document may be stored on a removable storage medium (e.g., a commercially available shrink wrap) with accompanying printed or electronic documentation. You may distribute it in any format, including as computer software (wrapped software) or It can be preloaded into the system (e.g., system ROM or fixed disk) or From a server or bulletin board to a communication system (e.g., the Internet or World Wide Web) It can also be distributed via the internet.

[0083] Hardware logic (programming logic) that implements all or part of the functionality described herein. (including programmable logic used in conjunction with programmable logic devices) They can be designed using traditional manual methods, or by computer-aided design (CAD), Hardware description language (e.g., VHDL or AHDL), or PLD programming language electronically using various tools such as grammar (e.g., PALASM, ABEL, or CUPL) It can also be designed, captured, simulated, or documented.

[0084] Programmable logic is a semiconductor memory device (e.g., RAM, ROM, PRO M, EEPROM, or flash programmable RAM), magnetic memory devices (e.g. a hard disk (e.g., a diskette or fixed disk), an optical memory device (e.g., a CD-ROM), or be fixed either permanently or temporarily to a tangible storage medium such as another memory device. Programmable logic is a technology that combines analog, digital, optical, and wireless technologies. (e.g., Bluetooth), networking technologies, and Internet working using any of a variety of communication technologies, including but not limited to Programmable logic can be attached to a signal that can be transmitted to a computer. Removable storage media containing printed or electronic documentation (e.g., commercial software) The software may be distributed as part of a computer system (e.g., in system ROM or hard disk drive). It can be preloaded onto a fixed disk or can be transmitted to a communication system from a server or electronic bulletin board. It may also be distributed via (e.g., the Internet or World Wide Web).

[0085] Various examples of suitable processing modules are discussed in more detail below. When used together, a module is adapted to perform a particular data processing or data transmission task. Typically, the preferred implementation is software, hardware, or firmware that In an embodiment, the module may receive instructions or OCT scan data, IVUS scan data, or data, interferometer signal data, target stent profile, post-stent deployment lumen profile Image and interpolated lumen profile view showing fully expanded stent, fully Geometry of the expanded stent-based lumen profile relative to the expanded lumen profile ratio of objective values, stent expansion level marking (color, hatching, etc.), pixel characteristic highlighting / Highlighting, side branch location, side branch diameter, stent expansion percentage or rate, pre-stent F FR values, post-stent FFR values, and other pre- and post-stent values, other information of interest Suitable for receiving, converting, routing and processing various types of data, such as "Software routine, program, or other memory-resident application" refers to a software routine, program, or other memory-resident application that executes a program or program.

[0086] The computers and computer systems described herein are used to acquire, process, and Record the software applications used when reading, storing, and / or communicating The method may include operably coupled computer-readable media, such as memory for storing the Such memory may be used by the computer or computer system to which it is operatively connected. Recognize that systems can be internal, external, remote, or local. can be done.

[0087] Memory may also be stored in a variety of storage media, including, but not limited to, hard disks, optical disks, floppy disks, and the like. Discs, DVDs (Digital Versatile Discs), CDs (Compact Discs), Memories tick, flash memory, ROM (read-only memory), RAM (random access memory) memory), DRAM (Dynamic Random Access Memory), PROM (Programmable Read Only Memory) EEPROM (Extended Erasable Programmable Read Only Memory), and / or other similar computer Including any means for storing software or other instructions, including a data-readable medium. can be done.

[0088] Generally, computer readable media applied in connection with the embodiments of the present disclosure described herein The memory medium is any medium capable of storing instructions that are executed by a programmable device. Where applicable, the method steps described herein may include , embodied or executed as instructions stored on one or more computer-readable memory media. These instructions can be written in various programming languages ​​such as C++, C, Java, etc. A programming language and / or a class that can be applied to create instructions according to embodiments of the present disclosure. Software embodied in various other types of software programming languages can be done.

[0089] The storage medium may be non-transitory or may include a non-transitory device. Thus, a non-transitory storage medium or device may include a tangible device, This means that a device may change its physical state but has a concrete physical form. Thus, for example, non-transient means that the data remains constant even if this state changes. This refers to the fact that the vise remains tangible.

[0090] The aspects, embodiments, features, and examples of the present disclosure are considered to be illustrative in all respects and are not to be construed as limiting the scope of the present disclosure. is not intended to limit the scope of the present disclosure, the scope of which is defined only by the claims. Other embodiments, modifications, and uses are within the spirit and scope of the claimed disclosure. It will be apparent to those skilled in the art without departing from the scope of the present invention.

[0091] The use of headings and paragraphs in this application is not meant to limit the disclosure, and each paragraph , may be applied to any aspect, embodiment, or feature of the present disclosure.

[0092] Throughout this application, compositions are referred to as having, including, or comprising certain components. or a process has, includes, or When stated to comprise, the composition of the present teachings does not consist essentially of the recited components. and the process of the present teachings essentially comprises the components listed. The process steps are listed in the table below. It is planned.

[0093] In this application, an element or component may be a list of enumerated elements or components. When a reference is made to an element or component being included in and / or selected from a list, that element or component is A component can be any one of the listed elements or components, Also, the elements or components may be selected from the group consisting of two or more of the listed elements or components. Furthermore, it should be understood that the elements of the compositions, devices, or methods described herein The elements and / or features, whether expressly or implicitly set forth herein, are within the scope of the present teachings. It is understood that the various elements may be combined in various ways without departing from the spirit and scope of the present invention. should be.

[0094] The terms "include", "includes", "including", " The use of "have," "has," or "having" should generally be understood to be open-ended and non-limiting unless otherwise specified. .

[0095] Use of the singular herein includes the plural (and vice versa) unless otherwise specified. Further, unless the context clearly dictates otherwise, the singular forms "a," "an," and "the" are used interchangeably. "The" includes plural forms. Furthermore, the terms "about" or "substantially" Where the use of "tantially" precedes a quantitative value, the present teachings are not intended to be limiting unless otherwise specified. The terms "about" and "substantially" as used herein include, for example, the quantitative value itself. Through real-world measurement or handling procedures, accidental changes in these procedures through tolerances, through differences / faults in the manufacturing of materials such as composite tapes, through defects Variations in the quantities that may occur, as well as variations where such variations are performed by the prior art. Unless otherwise specified, these values ​​will be recognized as equivalents by those skilled in the art. Typically, the terms "about" or "substantially" refer to a variation of 1 / 10 of the stated value, e.g. For example, ±10% means greater than or less than the stated value or range of values.

[0096] The order of steps or order for performing certain actions may be changed without departing from the spirit or scope of the present teachings. It should be understood that the number of steps is not critical, so long as the number of steps is not critical. The actions can be performed simultaneously.

[0097] The use of headings and paragraphs in this application is not meant to limit the disclosure. may be applied to any aspect, embodiment, or feature of the present disclosure. Only patent claims using "means for" are construed under 35 U.S.C. 112, 6 U.S.C. It is intended that the invention be In such cases, such claims should not be construed under 35 U.S.C. § 112. Any limitations from the specification shall be deemed to be inapplicable unless such limitations are expressly included in the claims. Nor is it intended to be read into the claims of the present application.

[0098] Where values ​​or ranges of values ​​are given, the endpoints of each value and the given range and the values ​​therebetween are Values ​​remain within the teachings of the present disclosure unless any different range is specifically stated. However, it can be increased or decreased by 20%.

[0099] If a range or list of values ​​is provided, the value between the upper and lower limits of that range or list of values Each intervening value is individually contemplated and is treated as if each value were specifically recited herein. Further, any smaller amounts between and including the upper and lower limits of a given range are encompassed within the present disclosure. Small ranges are contemplated and encompassed within this disclosure. A list of example values ​​or ranges may be used to It does not exclude other values ​​or ranges between and including the upper and lower limits of the range.

[0100] The figures and descriptions of the disclosure may be omitted for clarity, while other elements may be omitted to provide a clear understanding of the disclosure. It is understood that the present invention has been simplified to show elements that are relevant for the present invention. However, it will be appreciated that these and other factors may be desirable. However, because such elements are well known in the art and because they are not In order not to facilitate a better understanding of the disclosure, a description of such elements is not provided herein. It is understood that the figures are presented for illustrative purposes and not as structural diagrams. Omitted details and modifications or alternative embodiments are within the knowledge of those skilled in the art. It's inside.

[0101] In certain aspects of the present disclosure, to provide an element or structure, or to Replacing a single component with multiple components to perform a given function You can also replace multiple components with a single component. It can be recognized that such substitutions may be used to implement certain embodiments of the present disclosure. Except where not otherwise possible to achieve the same, such substitutions are considered to be within the scope of this disclosure. can be obtained.

[0102] The examples presented herein are intended to illustrate possible and specific implementations of the present disclosure. The examples are intended primarily to illustrate the present disclosure for those skilled in the art. No modifications to these figures or this specification may be made without departing from the spirit of this disclosure. There may be variations on the operations described in the document. For example, in certain cases, The steps or operations may be performed or executed in a different order or the operations may be It can be added, deleted or modified.

Claims

1. The one or more processors acquire a first set of subject images captured during a first time period; and acquiring a first set of time-varying data corresponding to the subject's cardiac cycle during said first period. And, The one or more processors convert a subset of the first set of subject images into the first and correlating with a subset of the time-varying data in the set The one or more processors generate a second set of subject images captured during a second time period. and a second set of time periods corresponding to the cardiac cycle of the subject acquired during the second period. and acquiring the variable data. The one or more processors convert the first set of time-varying data into the second set of time-varying data. Correlating with variable data and the one or more processors respond to a subset of the second set of time-varying data. identifying one or more image frames from the first set of subject images; The one or more processors select a plurality of image frames from the second set of subject images. the identified one or more images from the first set of subject images interlaced with the image. providing an image frame for display; 1. A method for displaying a set of images of a subject, comprising:

2. The first set of subject images are angiographic images and the second set of subject images are angiographic images. The method of claim 1 , wherein the image is a perspective image.

3. The fluoroscopic images are live images of the subject, and the second set of time-varying data comprises: The method of claim 2 , wherein the subject's live cardiac cycle data.

4. The first set of time-varying data and the second set of time-varying data are aortic (AO) The method of claim 1 , including a pressure value.

5. The first set of time-varying data and the second set of time-varying data include ECG values. The method of claim 1 .

6. The first period includes measuring the blood flow using an intravascular probe having one or more opaque markers. and further comprising simultaneously intravascularly imaging the subject, wherein intravascularly imaging the subject. , the method of claim 1 , generating a set of intravascular image frames.

7. co-registering the intravascular image frames with the first set of subject images; The method of claim 6, comprising:

8. one or more intravascular image frames corresponding to one or more live angiography frames or The method of claim 7 further comprising displaying the subset.

9. interlaced with a plurality of image frames from the second set of subject images. the identified one or more image frames from the first set of subject images for display. Providing includes providing one or more image frames from the second set of subject images to the and replacing one or more image frames from a set of subject images.

1. The method according to claim 1.

10. The one or more image frames from the second set of subject images and the one or more image frames from the first set of subject images. The one or more image frames from the subject image each correspond to a corresponding portion of the patient's cardiac cycle.

10. The method of claim 9, wherein the polymer is incorporated between a portion of the polymer.

11. interlaced with a plurality of image frames from the second set of subject images. the identified one or more image frames from the first set of subject images for display. Providing includes: providing a first set of subject images between image frames from the second set of subject images; and inserting the identified one or more image frames from a previous subject image. The method according to claim 1.

12. a memory for storing image data and time-varying data corresponding to the cardiac cycle of the subject; one or more processors in communication with the memory; wherein the one or more processors: a first set of images of the subject captured during a first period of time; acquiring a first set of time-varying data corresponding to the examiner's cardiac cycle; A subset of the first set of subject images is divided into a subset of the first set of time-varying data. and to correlate with the a second set of subject images captured during a second time period; a second set of time-varying data corresponding to the cardiac cycle of the subject; correlating the first set of time-varying data with the second set of time-varying data; the first set of subject images corresponding to a subset of the second set of time-varying data; identifying one or more image frames from the image; interlaced with a plurality of image frames from the second set of subject images. the identified one or more image frames from the first set of subject images for display. To provide and A system for displaying a set of images of a subject, the system being operable to:

13. The first set of subject images are angiographic images and the second set of subject images are angiographic images. The system of claim 12 , wherein the image is a fluoroscopic image.

14. The fluoroscopic images are live images of the subject, and the second set of time-varying data comprises: The system of claim 13 , wherein the subject's live cardiac cycle data.

15. The first set of time-varying data and the second set of time-varying data are aortic (AO) The system of claim 12 including a pressure value.

16. The first set of time-varying data and the second set of time-varying data include ECG values. The system of claim 12.

17. The first period includes measuring the blood flow using an intravascular probe having one or more opaque markers. and further comprising simultaneously intravascularly imaging the subject, wherein intravascularly imaging the subject. , generating a set of intravascular image frames.

18. interlaced with a plurality of image frames from the second set of subject images. the identified one or more image frames from the first set of subject images for display. Providing includes providing one or more image frames from the second set of subject images to the and replacing one or more image frames from a set of subject images.

13. The system described in 12.

19. The one or more image frames from the second set of subject images and the one or more image frames from the first set of subject images. The one or more image frames from the subject image each correspond to a corresponding portion of the patient's cardiac cycle.

20. The system of claim 18, wherein the system is interposed between the two portions.

20. The one or more processors acquire a first set of subject images captured during a first time period; and acquiring a first set of time-varying data corresponding to the subject's cardiac cycle during said first period. And, The one or more processors convert a subset of the first set of subject images into the first and correlating with a subset of the time-varying data in the set The one or more processors generate a second set of subject images captured during a second time period. and a second set of time periods corresponding to the cardiac cycle of the subject acquired during the second period. and acquiring the variable data. The one or more processors convert the first set of time-varying data into the second set of time-varying data. Correlating with variable data and the one or more processors respond to a subset of the second set of time-varying data. identifying one or more portions of the first set of subject images; The one or more processors perform a step of image processing on one or more images from the second set of subject images. for displaying the one or more portions of the first set of subject images overlaid on the and 10. A method for combining image data of a subject, comprising:

Images