Composition for suppressing accumulation of abdominal visceral fat

Abstract

To provide a novel composition for suppressing accumulation of abdominal visceral fat, a novel composition for reducing neutral fat, or a novel composition for reducing thigh circumference in humans, the compositions comprising a naturally derived component as an active ingredient.SOLUTION: The inventors have discovered that a heated ginger extract has effects of suppressing accumulation of abdominal visceral fat, reducing neutral fat, and reducing thigh circumference in humans, thereby completing the present invention.SELECTED DRAWING: Figure 1

Description

[Technical Field]

[0001] The present invention relates to a composition for inhibiting abdominal visceral fat accumulation, which contains a component derived from a natural product as an active ingredient. [Background technology]

[0002] It is known that excessive accumulation of visceral fat causes abnormal secretion of adipokines and increases the risk of high blood pressure and hyperglycemia. High blood pressure and hyperglycemia can also cause lifestyle-related diseases such as heart disease and diabetes, and it is believed that suppressing the accumulation of excess visceral fat contributes to reducing the risk of lifestyle-related diseases.

[0003] Under these circumstances, research into anti-obesity and other such factors is being actively conducted, and for example, an anti-obesity composition or a composition for inhibiting fat accumulation, which contains a yeast-fermented product of heated ginger extract as an active ingredient (Patent Document 1), and a cellulite prevention or improvement agent, which contains ginger or its extract as an active ingredient (Patent Document 2), are known. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Japanese Patent Application Publication No. 2023-143554 [Patent Document 2] Patent Publication No. 2021-50188 Summary of the Invention [Problem to be solved by the invention]

[0005] The present invention aims to provide a novel composition for inhibiting the accumulation of abdominal visceral fat in humans, a composition for reducing neutral fat, or a composition for reducing thigh circumference, which contains a component derived from a natural product as an active ingredient. [Means for solving the problem]

[0006] The inventors have discovered that heated ginger extract has the effect of inhibiting the accumulation of abdominal visceral fat, reducing neutral fat, and reducing thigh circumference in humans, and have completed the present invention.

[0007] That is, the present invention comprises the following features [1] to [9]. [1] A composition for inhibiting abdominal visceral fat accumulation in humans, containing heated ginger extract as an active ingredient. [2] The composition for inhibiting abdominal visceral fat accumulation described in [1], wherein the heated ginger extract contains more shogaol than gingerol. [3] A food or drink, a medicine, or a quasi-drug containing the composition according to [1] or [2] for inhibiting abdominal visceral fat accumulation in humans. [4] A composition for reducing human neutral fat, containing heated ginger extract as an active ingredient. [5] The composition for reducing neutral fat in humans described in [4], wherein the heated ginger extract contains more shogaol than gingerol. [6] A food or drink, pharmaceutical product, or quasi-drug for reducing human neutral fat, comprising the composition according to [4] or [5]. [7] A composition for reducing thigh circumference in humans, containing heated ginger extract as an active ingredient. [8] The composition for reducing thigh circumference in humans described in [7], wherein the heated ginger extract contains more shogaol than gingerol. [9] A food or drink, medicine, or quasi-drug for reducing thigh circumference in humans, comprising the composition according to [7] or [8]. [Effects of the Invention]

[0008] The present invention provides a safe composition for inhibiting abdominal visceral fat accumulation in humans, a composition for reducing triglycerides, or a composition for reducing thigh circumference, which contains a component derived from a natural product as an active ingredient. When ingested, the composition can provide an effect of inhibiting abdominal visceral fat accumulation in humans, a effect of reducing triglycerides, or a effect of reducing thigh circumference, and can be used by being incorporated into various foods and beverages, pharmaceuticals, quasi-drugs, etc. [Brief explanation of the drawings]

[0009] [Figure 1]This is a graph showing abdominal visceral fat area (cm2) in the test food group and placebo group before screening and after 12 weeks of intake. [Figure 2] 1 is a graph showing the change (cm2) in abdominal visceral fat area over 12 weeks in the test food group and the placebo group. [Figure 3] This is a graph showing triglycerides (mg / dL) before screening and 12 weeks after intake in the test food group and placebo group for the PPS group and those under 40 years of age. [Figure 4] This is a graph showing the change in triglyceride levels (mg / dL) over 12 weeks in the test food group and placebo group in the PPS group under 40 years of age. [Figure 5] This is a graph showing thigh circumference (cm) before screening and after 12 weeks of intake in the test food group and placebo group for those with PPS and an average abdominal visceral fat area of ​​119.6 cm2 or more. [Figure 6] This is a graph showing the change (cm) in thigh circumference over 12 weeks in the test food group and placebo group for the group with PPS and an average abdominal visceral fat area of ​​119.6 cm2 or more. [Figure 7] This is a graph showing thigh circumference (cm) before screening and after 12 weeks of intake in the test food group and placebo group for PPS and age 48.2 years or older. [Figure 8] This is a graph showing the change (cm) in thigh circumference over 12 weeks in the test food group and placebo group for PPS and age 48.2 years or older. DETAILED DESCRIPTION OF THE INVENTION

[0010] The composition for inhibiting abdominal visceral fat accumulation in humans, the composition for reducing triglycerides, or the composition for reducing thigh circumference of the present invention contains heated ginger extract as an active ingredient, and when ingested, it exerts an effect of inhibiting abdominal visceral fat accumulation in humans, an effect of reducing blood triglycerides, or an effect of reducing thigh circumference. The effect of reducing triglycerides is significant in people under 40 years of age, and the effect of reducing thigh circumference is significant when the abdominal visceral fat area is 119.6 cm 2 or above 120cm 2 It is particularly noticeable in those aged 48.2 years or older, 49 years or older, or 50 years or older.

[0011] The heated ginger extract used in the present invention is preferably a non-fermented extract obtained by heating a plant of the Zingiberaceae family before or after extraction. Examples of extraction methods include supercritical extraction, steam distillation, and solvent extraction. The ginger extract may be subjected to solid-liquid separation by filtration using a nonwoven fabric or mesh, centrifugation, or the like, followed by heat treatment. Alternatively, the liquid portion may be recovered by extraction or solid-liquid separation after heat treatment. Concentrated and / or dried products are preferred, and can be dried and powdered by drum drying, air drying, spray drying, vacuum drying, and / or freeze drying, for example. Conventional excipients can be used. Specifically, the heated ginger extract is preferably a powder obtained by emulsifying with an emulsifier to enhance dispersibility, blending with an excipient such as dextrin, and spray drying. For example, Ginger Extract Powder S, H, E, or NE (manufactured by Ikeda Tohka Kogyo Co., Ltd.) can be used. It is known that the gingerol content is much lower in raw plants or in uncooked ginger extracts, but in the present invention, the gingerol content is increased by performing a treatment such as heating before or after extraction, and the heated ginger extract preferably contains more gingerol than gingerol, more preferably 1.5 times or more gingerol, more preferably 2 times or more, and particularly preferably 3 times or more. The upper limit is not particularly limited, but 15 times or less is preferable, and 10 times or less is more preferable. A heated ginger extract with a high gingerol content can be produced by heating at, for example, 100 to 300°C, preferably 120 to 250°C, as long as the gingerol content is increased, and is not particularly limited as long as the production method is. The gingerol content in the heated ginger extract is preferably 0.1 to 20% by weight, more preferably 0.2 to 15% by weight, and even more preferably 0.5 to 10% by weight, and the zingiberene content is preferably 0.1% by weight or less, more preferably 0.05% by weight or less, and even more preferably 0.01% by weight or less.

[0012] The emulsifier is not particularly limited as long as it is a component having emulsifying ability, and examples thereof include polysaccharides such as gum acacia, gum ghatti, xanthan gum, and starch sodium octenyl succinate, proteins or protein hydrolysates such as casein and soybean protein, lecithin, enzyme-treated lecithin, polyglycerol fatty acid esters, and sucrose fatty acid esters. The emulsification treatment can be carried out by a general emulsification method. Specifically, the emulsification treatment can be carried out using an emulsification device, such as a high-pressure homogenizer, a colloid mill, an ultrasonic emulsifier, a homomixer, or a homodisper, and two or more types of devices can be combined.

[0013] The method of ingestion of the composition of the present invention involves oral ingestion of the heated ginger extract. The amount of intake is not particularly limited as long as the effects of the present invention are observed. The daily intake of heated ginger extract per person is preferably 5 to 2,000 mg, more preferably 10 to 1,000 mg, and even more preferably 20 to 500 mg. The daily intake of 6-shogaol contained in the heated ginger extract per person is preferably 0.1 to 50 mg, more preferably 0.2 to 40 mg, even more preferably 0.4 to 20 mg, and particularly preferably 0.5 to 15 mg. To achieve this intake, the composition of the present invention may be taken once a day or in divided doses. Continuous ingestion is preferred, and for example, for at least 1 week, at least 2 weeks, at least 5 weeks, at least 8 weeks, at least 10 weeks, or at least 12 weeks is more preferred.

[0014] The composition of the present invention, whose active ingredients are derived from natural products and is easy to manufacture, is widely applicable and can be added to various products, either in liquid or dried form. The foods and beverages to which the composition can be added are not particularly limited, and the composition can be used in various foods and beverages, such as beverages, foods, seasonings, functional foods, and supplements, as well as pharmaceuticals and quasi-drugs. Examples include foods and beverages for inhibiting visceral fat accumulation, reducing triglycerides, or reducing thigh circumference, as well as pharmaceuticals and quasi-drugs. The content of heated ginger extract in various products is not particularly limited, as long as the effects of the present invention are observed when ingested, but is preferably 0.001 to 80% by weight, more preferably 0.005 to 60% by weight, and even more preferably 0.01 to 50% by weight. [Example]

[0015] The present invention will be specifically described below with reference to examples, but the present invention is not limited to the following examples. In the present invention, all % is by weight unless otherwise specified.

[0016] [Example 1] (Abdominal visceral fat area evaluation test) This study was conducted on healthy Japanese adult men and women with a BMI of 25 kg / m 2 More than 30kg / m 2 Subjects with a mean age of less than 18 years and relatively large abdominal visceral fat area at the screening and pre-intake test were asked to take one capsule containing 100 mg of heated ginger extract, the active ingredient of which is 6-shogaol, once daily for 12 consecutive weeks to examine the effect on body fat. 68 subjects were assigned to a test food group and a placebo group, with 34 subjects each. The analysis dataset for efficacy evaluation items was a per protocol analysis set (PPS). Five subjects (2 subjects in the test food group, 3 subjects in the placebo group) with a test food intake rate of less than 80% were excluded, leaving 63 subjects (32 subjects in the test food group, 31 subjects in the placebo group) for this study.

[0017] The capsules for the test food group contained 100 mg (40%) of powdered heated ginger extract (Ginger Extract Powder E, Ikeda Tohka Kogyo Co., Ltd.) obtained by adding acacia gum (instant gum, manufactured by Nexira Co., Ltd.) as an emulsifier to heated ginger extract, followed by the addition of dextrin (Sandec (registered trademark) #300, manufactured by Sanwa Starch Co., Ltd.) as an excipient, and spray drying the resulting mixture. The resulting mixture contained 147 mg (58.8%) of dextrin (Pinedex (registered trademark) #100, manufactured by Matsutani Chemical Industry Co., Ltd.), and 3 mg (1.2%) of calcium stearate (total 250 mg). The capsules for the placebo group contained 100 mg of dextrin (Sandec (registered trademark) #300), 147 mg of dextrin (Pinedex (registered trademark) #100), and 3 mg of calcium stearate (total 250 mg).

[0018] The contents of 6-gingerol, 6-shogaol, and 6-paradol contained in the heated ginger extract (ginger extract powder E) are shown in Table 1.

[0019] [Table 1]

[0020] At screening and before intake and at the 12-week examination, abdominal visceral fat area was evaluated by measuring the fat area in the cross section of the umbilicus using X-ray CT. The results are shown as the mean and standard deviation, and comparisons were made between groups using ANCOVA with baseline (at screening and before intake) as a covariate. Abdominal visceral fat area (cm) at screening and before intake and at 12 weeks 2 ) are shown in Figure 1, and the change in abdominal visceral fat area (cm 2 ) is shown in Figure 2.

[0021] As shown in Figures 1 and 2, the abdominal visceral fat area was significantly lower in the test food group compared to the placebo group at the time of examination 12 weeks after intake, confirming the effect of taking 100 mg / day of heated ginger extract in suppressing visceral fat accumulation.

[0022] [Example 2] (Neutral fat evaluation test) Triglycerides (TG) were measured and evaluated by peripheral blood tests at screening and before intake and at the 12-week test. Stratified analysis showed that in the PPS group under 40 years of age (5 cases in the test food group, 6 cases in the placebo group), the actual measured triglyceride (TG) values ​​and changes at the test 12 weeks after intake of the test food group were significantly lower than those in the placebo group. Triglycerides (mg / dL) before screening and intake and after 12 weeks are shown in Figure 3, and the changes in triglycerides over 12 weeks (mg / dL) are shown in Figure 4.

[0023] From the above, it was revealed that taking 100 mg / day of heated ginger extract has a triglyceride-reducing effect in people under 40 years of age, and it was found that heated ginger extract is a useful composition for reducing triglycerides in people under 40 years of age, containing the active ingredient.

[0024] [Example 3] (Thigh circumference evaluation test) At the screening and pre-intake examination and at the 12-week post-intake examination, thigh circumference (right leg, left leg, and average of both legs) was measured and evaluated. The thigh circumference was measured by wrapping a tape measure around the thigh so that it was horizontal at a height of 10 cm from the upper edge of the patella on the central side. As a result of stratified analysis, the average value of PPS and abdominal visceral fat area was 119.6 cm. 2 In the above groups (15 in the test food group, 12 in the placebo group) and the group with PPS and an average age of 48.2 years or older (13 in the test food group, 17 in the placebo group), the actual thigh circumference measurements and changes at the time of examination after 12 weeks of intake of the test food group were significantly lower than those in the placebo group. PPS and abdominal visceral fat area average: 119.6 cm 2 Figure 5 shows the thigh circumference (cm) of the above groups before screening and after 12 weeks of intake, and Figure 6 shows the change in thigh circumference (cm) over 12 weeks. Figure 7 shows the thigh circumference (cm) of the PPS group aged 48.2 years or older before screening and after 12 weeks of intake, and Figure 8 shows the change in thigh circumference (cm) over 12 weeks.

[0025] From the above, the average abdominal visceral fat area is 119.6 cm 2 In the above group and the group aged 48.2 years or older, the intake of 100 mg / day of heated ginger extract was found to have a reducing effect on thigh circumference, and abdominal visceral fat area was reduced by 119.6 cm 2 It has been found that the composition containing heated ginger extract as an active ingredient is useful for reducing thigh circumference in people aged 48.2 years or older or 48.2 years or older.

Claims

1. A composition for inhibiting abdominal visceral fat accumulation in humans, comprising heated ginger extract as an active ingredient.

2. 2. The composition for inhibiting abdominal visceral fat accumulation according to claim 1, wherein the heated ginger extract contains more shogaol than gingerol.

3. A food or drink, a drug or a quasi-drug, which comprises the composition according to claim 1 or 2 and is used to inhibit abdominal visceral fat accumulation in humans.

4. A composition for reducing human neutral fat, containing heated ginger extract as an active ingredient.

5. 5. The composition for reducing neutral fat in humans according to claim 4, wherein the heated ginger extract contains more shogaol than gingerol.

6. A food or drink, a medicine, or a quasi-drug, which comprises the composition according to claim 4 or 5 and is used to reduce neutral fat in humans.

7. A composition for reducing thigh circumference in humans, comprising heated ginger extract as an active ingredient.

8. 8. The composition for reducing thigh circumference in humans according to claim 7, wherein the heated ginger extract contains more shogaol than gingerol.

9. A food or drink, a medicine, or a quasi-drug, which comprises the composition according to claim 7 or 8 and is used to reduce thigh circumference in humans.

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