Concentration bag and processing system

Abstract

To provide a concentration bag and a processing system that suppress clogging and the like of a concentrator by enabling delivery of a relatively dilute body fluid, thereby allowing stable execution of a recirculation process.SOLUTION: A concentration bag for collecting a concentrated liquid used in a processing system for treating blood and / or body cavity fluid comprises a concentration line for delivering the concentrated liquid into the concentration bag, and a recirculation line for withdrawing the liquid in the concentration bag for reconcentration, where a mouth of the recirculation line is arranged at a position higher than a mouth of the concentration line.SELECTED DRAWING: Figure 1

Description

[Technical Field]

[0001] The present invention relates to a concentrate bag and a processing system. [Background technology]

[0002] One treatment for ascites, a type of body cavity fluid, is cell-free and concentrated ascites reinfusion therapy, in which the ascites is extracted from the patient, pathogenic substances such as bacteria and cancer cells are removed from the ascites, the fluid is concentrated while leaving useful components such as albumin, and the concentrated fluid is then returned to the body.

[0003] Such treatment generally uses an ascites treatment system. This ascites treatment system consists of an ascites bag, a filter, a concentrator, and a concentrated ascites bag, connected in that order, and filters and concentrates the ascites by pumping or using a drop in the water. Separation membranes such as hollow fiber membranes are used in the filter and concentrator.

[0004] Furthermore, some ascites treatment systems as described above have a function of performing a re-concentration process in which concentrated ascites collected in a concentrated ascites bag is re-concentrated in a concentrator and circulated back to the concentrated ascites bag (see, for example, Patent Document 1). In this ascites treatment system, the concentration and volume of the concentrated ascites produced can be adjusted by combining the above-mentioned filtration / concentration process with re-concentration. [Prior art documents] [Patent documents]

[0005] [Patent Document 1] Japanese Patent Application Publication No. 2019-80975 Summary of the Invention [Problem to be solved by the invention]

[0006] In the body cavity fluid treatment system and other blood treatment systems, the concentrated body fluid that has passed through the filter or concentrator is stored in a concentrate bag, and the concentrated body fluid may be recirculated from the concentrate bag to the concentrator to adjust the volume of the concentrated body fluid stored in the concentrate bag.

[0007] In this case, the concentrated body fluid stored in the concentrate bag tends to be relatively denser at the bottom and thinner at the top, so in a conventional concentrate bag configuration where the line supplying the concentrated body fluid and the line for recirculation are located at the bottom, the dense body fluid is likely to be sent to the concentrator. This increases the pressure on the concentrator during the recirculation process, resulting in a large loss of useful substances from the ascites and the possibility of the concentrator becoming clogged, causing an interruption to treatment.

[0008] The present invention has been made in consideration of the above-mentioned problems, and aims to provide a concentration bag and processing system that can prevent clogging of the concentrator by making it possible to transport relatively dilute body fluids, and can perform recirculation processing stably. [Means for solving the problem]

[0009] That is, the present invention is as follows. [1] A concentrate bag for collecting a concentrate used in a treatment system for treating blood and / or body cavity fluid, comprising: a concentrate line for delivering concentrated liquid into the concentrate bag; a recirculation line for removing liquid from the concentrate bag for reconcentration; The mouth of the recirculation line is configured at a higher position than the mouth of the concentrate line. Concentrate bag. [2] the recirculation line port and the concentrate line port are provided at the bottom of the concentrate bag; The bottom of the concentrate bag is inclined, The recirculation line opening is positioned higher than the concentration line opening at the bottom of the concentration bag. The concentrated bag described in [1]. [3] The recirculation line is a tube inserted into the concentrate bag from below, the mouth of the recirculation line is located within the concentrate bag; The concentrated bag described in [1]. [4] The recirculation line is provided to the side or above the concentrate bag. The concentrated bag described in [1]. [5] A concentrate bag for collecting a concentrate used in a treatment system for treating blood and / or body cavity fluid, comprising: a concentrate line for delivering the concentrated liquid into the concentrate bag; a recirculation line for removing the liquid in the concentrate bag for reconcentration; a partition capable of preventing a liquid having a higher concentration than the liquid delivered from the concentration line from moving to the recirculation line; Equipped with Concentrated Bag [6] The partition extends upward from the bottom of the bag to at least partially separate the concentrate line from the recirculation line. The concentrated bag described in [5]. [7] The partition is provided upward from the side of the concentrate bag so as to at least partially separate the concentrate line from the recirculation line. The concentrated bag described in [5]. [8] The concentrated liquid delivered from the concentration line can be stored in a space formed by the partition and the upper and / or side of the concentration bag. The concentrated bag described in [5]. [9] The height, length, and angle of the partition with the base or side are variable. The concentrated bag described in [5].

[10] The partition includes a first portion and a second portion located above the first portion, and the first portion has a lower water permeability than the second portion. The concentrated bag described in [5].

[11] A concentrate bag for collecting a concentrate used in a treatment system for treating blood and / or body cavity fluid, comprising: a concentrate line for delivering concentrated liquid into the concentrate bag; a recirculation line for removing liquid from the concentrate bag for reconcentration; a partition at least partially separating the concentrate line from the recirculation line; Equipped with Concentrate bag.

[12] A set of concentrate bags including a concentrate bag for collecting concentrate used in a treatment system for treating blood and / or body cavity fluid, and a jig for clamping the concentrate bag from the outside, The concentrate bag includes a concentrate line for delivering concentrated liquid into the concentrate bag and a recirculation line for removing liquid from the concentrate bag for reconcentration; The jig sandwiches the concentration bag from the outside to form a partition that at least partially separates a first space on the concentration line side from a second space on the recirculation line side. A set of concentrate bags.

[13] The concentration bag has a mark indicating the position where it is clamped by the jig. A set of concentrated bags according to

[12] .

[14] The jig is at least a part of a holding portion of the concentrate bag included in a processing system for processing blood and / or body cavity fluid. A set of concentrated bags according to

[12] .

[15] 1. A treatment system for treating blood and / or body cavity fluids, comprising: A set of the concentrated bag according to any one of [1] to

[11] or the concentrated bag according to any one of

[12] to

[14] ; A concentrator; a first flow path connecting the recirculation line of the concentrate bag and the concentrator; a second flow path connecting the concentrator and a concentration line of the concentration bag; a first liquid delivery unit provided in the first flow path and configured to discharge the liquid from the concentrate bag via the recirculation line and the first flow path; a second liquid delivery unit provided in the second flow path and configured to supply the liquid to the concentration bag via the concentration line and the second flow path; A control unit that controls the first liquid delivery unit and the second liquid delivery unit, Processing system.

[16] the control unit controls driving or stopping of the first liquid delivery unit depending on the amount of liquid delivered by the second liquid delivery unit. The processing system according to

[15] .

[17] The control unit controls the driving or stopping of the first liquid delivery unit according to the weight of the concentrated bag. The processing system according to

[15] .

[18] When the concentration bag has a partition, either alone or by a jig, the control unit controls driving or stopping of the first liquid delivery unit depending on the height and length of the partition and the angle formed between the partition and a downward or lateral direction. The processing system according to

[15] .

[19] the recirculation line has a detector that detects the presence or absence of liquid in the recirculation line; Controlling the driving or stopping of the first liquid delivery unit according to the detection result of the detection unit. The processing system according to

[15] . [Effects of the Invention]

[0010] According to the present invention, it is possible to provide a concentrate bag and a processing system that can prevent clogging of the concentrator by making it possible to send relatively dilute body fluids, and that can perform recirculation processing stably. [Brief explanation of the drawings]

[0011] [Figure 1] 1 is an explanatory diagram showing an outline of the configuration of a processing system according to an embodiment of the present invention; [Figure 2A] 1 is a schematic diagram showing one aspect of a concentrate bag of the first embodiment. FIG. [Figure 2B] 1 is a schematic diagram showing one aspect of a concentrate bag of the first embodiment. FIG. [Figure 2C] 1 is a schematic diagram showing one aspect of a concentrate bag of the first embodiment. FIG. [Figure 2D] FIG. 10 is a schematic diagram showing one aspect of the concentrate bag of the second embodiment. [Figure 2E] FIG. 10 is a schematic diagram showing one aspect of the concentrate bag of the second embodiment. [Figure 2F] FIG. 10 is a schematic diagram showing one aspect of the concentrate bag of the second embodiment. [Figure 2G] FIG. 1 is a schematic diagram showing one aspect of a set of concentrate bags according to the present embodiment. [Figure 2H] FIG. 10 is a schematic diagram showing one aspect of the concentrate bag of the second embodiment. [Figure 3] FIG. 2 is a schematic diagram showing a concentrated bag disposed in the treatment device of the present embodiment. DETAILED DESCRIPTION OF THE INVENTION

[0012] An embodiment of the present invention (hereinafter referred to as "the present embodiment") will be described in detail below, but the present invention is not limited to this and various modifications are possible without departing from the spirit of the present invention. In the drawings, the same elements are given the same reference numerals and redundant explanations will be omitted. Furthermore, positional relationships such as up, down, left, and right will be based on the positional relationships shown in the drawings unless otherwise specified. Furthermore, the dimensional ratios of the drawings are not limited to those shown in the drawings.

[0013] 1 is an explanatory diagram showing an outline of the configuration of a processing system of this embodiment. The processing system 1 of this embodiment is a processing system for processing blood and / or body cavity fluid.

[0014] The processing system 1 includes a processing bag 10, a filter 11, a concentrator 12, a concentration bag 13, a first liquid transfer line 14, a second liquid transfer line 15, a third liquid transfer line 16, a fourth liquid transfer line 17, a fifth liquid transfer line 18, a sixth liquid transfer line 19, a cleaning liquid supply means 20, a weighing scale 21, etc.

[0015] The processing bag 10 is, for example, a flexible bag, and is capable of containing ascites collected from a patient.

[0016] The filter 11 has, for example, a cylindrical housing. The filter 11 has liquid passage ports 11a and 11b at both ends in the longitudinal direction (vertical direction) and two liquid passage ports 11c and 11d on its side. In this specification, the up and down directions of the processing system 1 are based on the posture during normal use.

[0017] The filter 11 includes a filtration membrane 30 that removes predetermined pathogenic substances such as bacteria and cancer cells and allows predetermined useful components such as albumin to pass through. The filtration membrane 30 is composed of, for example, a number of hollow fiber membranes. A space 30a on the primary side of the filtration membrane 30 (the internal space of the hollow fiber membrane) communicates with the liquid passage ports 11a and 11b, and a space 30b on the secondary side of the filtration membrane 30 (the external space of the hollow fiber membrane) communicates with the liquid passage ports 11c and 11d.

[0018] The concentrator 12 has, for example, a cylindrical housing. The concentrator 12 has liquid passage ports 12a and 12b at both ends in the longitudinal direction (vertical direction) and two liquid passage ports 12c and 12d on the side surface.

[0019] The concentrator 12 is equipped with a concentration membrane 40 that removes water from, for example, ascites and concentrates it. The concentration membrane 40 is composed of, for example, a number of hollow fiber membranes. A space 40a on the primary side of the concentration membrane 40 (the inner space of the hollow fiber membrane) communicates with the liquid passage ports 12a and 12b, and a space 40b on the secondary side of the concentration membrane 40 (the outer space of the hollow fiber membrane) communicates with the liquid passage ports 12c and 12d.

[0020] The concentrated bag 13 is, for example, a flexible bag, and can contain the concentrated ascites concentrated in the concentrator 12 .

[0021] The first fluid supply line 14 connects the processing bag 10 and the filter 11. The upstream end of the first fluid supply line 14 is connected to the processing bag 10, and the downstream end of the first fluid supply line 14 is connected to the fluid passage 11a of the filter 11. That is, the fluid passage 11a of the filter 11 serves as the inlet of the filter 11 into which the ascites flows. In this specification, the "upstream side" refers to the direction that is the upstream side during normal ascites treatment, in which the ascites flows through the filter 11 and then the concentrator 12, and the "downstream side" refers to the direction that is the downstream side during normal ascites treatment.

[0022] A first pressure measuring device 50 is provided in the first liquid supply line 14. The first pressure measuring device 50 is in communication with the space 30a on the primary side of the filter 11, and is capable of measuring the pressure in this space 30a.

[0023] The upstream end of the sixth liquid supply line 19 is connected to the liquid passage port 11b of the filter 11. The downstream end of the sixth liquid supply line 19 is connected to a waste liquid section (not shown) that receives, for example, the drained liquid removed from the ascites by the filter 11.

[0024] A gas introduction line 70 that is open to the atmosphere is connected to the liquid passage port 11c of the filter 11. A second pressure measuring device 71 that can measure the pressure in the space 30b on the secondary side of the filter 11 is connected to the gas introduction line 70.

[0025] The second liquid feed line 15 connects the filter 11 and the concentrator 12. The upstream end of the second liquid feed line 15 is connected to the liquid passage port 11d of the filter 11, and the downstream end of the second liquid feed line 15 is connected to the liquid passage port 12a at the upper end of the concentrator 12. In other words, the liquid passage port 11d of the filter 11 serves as the outlet of the filter 11, and the liquid passage port 12a of the concentrator 12 serves as the inlet of the concentrator 12.

[0026] In the second liquid transfer line 15, for example, a valve 80, a first liquid transfer unit 81, and a drip chamber 82 are provided in this order from the upstream side to the downstream side. The valve 80 opens and closes the second liquid transfer line 15. The first liquid transfer unit 81 is a tube pump that transfers liquid through the tube of the second liquid transfer line 15. The first liquid transfer unit 81 also functions as a blocking means for blocking the tube when stopped.

[0027] A third pressure measuring device 83 is connected to the drip chamber 82. The third pressure measuring device 83 is in communication with the space 40a on the primary side of the concentrator 12, and is capable of measuring the pressure in this space 40a.

[0028] The third liquid feed line 16 connects the concentrator 12 and the concentration bag 13. The upstream end of the third liquid feed line 16 is connected to the liquid passage port 12b at the lower end of the concentrator 12, and the downstream end of the third liquid feed line 16 is connected to the concentration line 132 of the concentration bag 13. In other words, the liquid passage port 12b of the concentrator 12 serves as the first outlet of the concentrator 12.

[0029] The third liquid transfer line 16 is provided with a second liquid transfer unit 90. The second liquid transfer unit 90 is a tube pump that transfers liquid through the tube of the third liquid transfer line 16. The second liquid transfer unit 90 may also function as a blocking means for blocking the tube when stopped.

[0030] An upstream end of the fourth liquid supply line 17 is connected to, for example, the liquid passage ports 12c and 12d of the concentrator 12. That is, the liquid passage ports 12c and 12d of the concentrator 12 serve as second outlets of the concentrator 12. The upstream end of the fourth liquid supply line 17 may be connected to only one of the liquid passage ports 12c and 12d. A downstream end of the fourth liquid supply line 17 is connected to a waste liquid section (not shown) that receives the effluent (mainly water) removed from the ascites by the concentrator 12.

[0031] The fourth liquid supply line 17 is provided with a valve 100 and a fourth pressure measuring device 101. The valve 100 opens and closes the fourth liquid supply line 17. The fourth pressure measuring device 101 is connected to the space 40b on the secondary side of the concentrator 12 and can measure the pressure in this space 40b.

[0032] The fifth liquid transfer line 18 connects the concentrate bag 13 and the second liquid transfer line 15. One end (upstream end) of the fifth liquid transfer line 18 is connected to the concentrate bag 13. The other end (downstream end) of the fifth liquid transfer line 18 is connected to the second liquid transfer line 15 upstream of the first liquid transfer section 81. The fifth liquid transfer line 18 is provided with a valve 110 that opens and closes the fifth liquid transfer line 18. The first to sixth liquid transfer lines 14 to 19 are made of, for example, flexible tubes.

[0033] The cleaning liquid supply means 20 supplies the cleaning liquid to the second liquid transfer line 15. The supply means 20 includes, for example, a storage section 120 that stores the cleaning liquid, a supply line 121 that connects the storage section 120 to the second liquid transfer line 15, and a valve 122 as an opening / closing means for opening and closing the supply line 121. The supply line 121 is connected to the second liquid transfer line 15 downstream of the first liquid transfer section 81. The opening / closing means may be a pump instead of a valve. The cleaning liquid is, for example, physiological saline.

[0034] The pressure measurement results of the first to fourth pressure measuring devices 50, 71, 83, and 101 are output to the control unit 5. From the pressure P1 measured by the first pressure measuring device 50 and the pressure P2 measured by the second pressure measuring device 71, the transmembrane pressure in the filter 11 (the pressure difference P3 (P1-P2) between the primary space 30a and the secondary space 30b) can be measured. Furthermore, from the pressure P4 measured by the third pressure measuring device 83 and the pressure P5 measured by the fourth pressure measuring device 101, the transmembrane pressure in the concentrator 12 (the pressure difference P6 (P4-P5) between the primary space 40a and the secondary space 40b) can be measured.

[0035] Weigh scale 21 can measure the weight of concentrate bag 13. The measurement results of weigh scale 21 are output to control unit 5. The measurement results of weigh scale 21 can be used to measure the weight of concentrate bag 13 and the volume of concentrated ascites in concentrate bag 13. The volume of concentrated ascites in concentrate bag 13 is calculated by subtracting the weight of empty concentrate bag 13 from the weight of concentrate bag 13 containing concentrated ascites, for example.

[0036] 1. Concentrate Bag 1.1. Concentration Bag (First Embodiment) The concentration bag 13 of the first embodiment is a concentration bag 13 for recovering concentrated liquid used in the above-mentioned processing system 1, and is equipped with a concentration line 132 for sending concentrated liquid to the internal space 131 of the concentration bag, and a recirculation line 133 for removing the liquid in the concentration bag for re-concentration, and the mouth 133a of the recirculation line 133 is configured at a higher position than the mouth 132a of the concentration line 132.

[0037] The body fluid sent from the concentration line 132 to the internal space 131 can create a concentration gradient in the internal space 131, with the upper layer having a relatively low concentration and the lower layer having a relatively high concentration. Therefore, with the above configuration, the liquid with a relatively low concentration located in the upper layer of the concentration bag 13 flows into the recirculation line 133 in preference to the liquid with a relatively high concentration located in the lower layer. Therefore, by being able to send a relatively dilute body fluid, clogging of the concentrator 12 can be suppressed, and the recirculation process can be performed stably.

[0038] 2A to 2C show schematic configuration diagrams of the concentration bag 13 of the first embodiment. As shown in Fig. 2A, at least a portion of the bottom side 13a of the concentration bag 13 is inclined, and the opening 133a of the recirculation line 133 and the opening 132a of the concentration line 132 may be provided on the bottom side 13a of the concentration bag 13. In this case, the opening 133a of the recirculation line 133 is provided on the inclined portion 13a1 of the bottom side 13a of the concentration bag 13, so that the opening 133a is positioned higher than the opening 132a of the concentration line 132.

[0039] 2A shows an example in which the port 132a of the concentration line 132 is provided in the non-inclined portion 13a2 of the bottom side 13a, but instead, the port 132a of the concentration line 132 may be provided in the inclined portion 13a1. In this case, however, the port 132a of the concentration line 132 is located in the inclined portion 13a1 so as to be lower than the port 133a of the recirculation line 133.

[0040] 2H, a slope other than slope 13a1 may be provided on the bottom side of the bag, and port 132a of concentration line 132 may be provided on that slope. In this case, port 133a of recirculation line 133 is located above bottom side 13a, so that the liquid with a relatively low concentration located in the upper layer of concentration bag 13 flows into recirculation line 133 in preference to the liquid with a relatively high concentration located in the lower layer.

[0041] In addition, in the example shown in FIG. 2A, the bottom side 13a has the inclined portion 13a1 and the non-inclined portion 13a2, but the bottom side 13a does not have to have the non-inclined portion 13a2.

[0042] 2B , the recirculation line 133 may be a tube inserted into the concentrate bag 13 from below, and the opening 133a of the recirculation line 133 may be located inside the concentrate bag 13. In other words, the tube of the recirculation line 133 may extend from the bottom 13a of the concentrate bag 13 further into the internal space 131.

[0043] In this case, the mouth 132a of the concentration line 132 may be located at the bottom 13a of the concentration bag 13, as shown in Figure 2B, or the tube of the concentration line 132 may extend further from the bottom 13a of the concentration bag 13 into the internal space 131, as long as it does not exceed the height of the mouth 133a of the recirculation line 133.

[0044] 2C, the recirculation line 133 may be provided on the side 13c or on the top 13b of the concentrate bag 13. This allows the liquid with a relatively low concentration located in the upper layer to be guided to the recirculation line 133 when a predetermined amount of liquid is accumulated in the concentrate bag 13 and the liquid level reaches the opening 133a of the recirculation line 133 provided on the side 13c or on the top 13b.

[0045] The recirculation line 133 provided on the side 13c or upper portion 13b of the concentration bag 13 may extend further from the side 13c or upper portion 13b into the internal space 131, as shown in Figure 2C, or the opening 133a of the recirculation line 133 may be located on the side 13c or upper portion 13b of the concentration bag 13.

[0046] The recirculation line 133 may be provided on either the side 13c or the top 13b of the concentrate bag 13, or on both as shown in Figure 2C. When the recirculation line 133 is provided on both the side 13c or the top 13b, in actual use, one recirculation line 133 may be closed and liquid may be collected from the other recirculation line 133.

[0047] 2C , the port 132a of the concentration line 132 may be located at the bottom 13a of the concentration bag 13, or the tube of the concentration line 132 may extend from the bottom 13a of the concentration bag 13 into the internal space 131, as long as the height from the bottom 13a does not exceed the height of the port 133a of the recirculation line 133. The port 132a of the concentration line 132 may be located on the side 13c, or may extend from the side 13c into the internal space 131, as long as the height from the bottom 13a does not exceed the height of the port 133a of the recirculation line 133. The port 132a of the concentration line 132 may extend from the top 13b into the internal space 131, as long as the height from the bottom 13a does not exceed the height of the port 133a of the recirculation line 133.

[0048] 1.2. Concentration Bag (Second Embodiment) The concentration bag 13 of the second embodiment is a concentration bag for recovering concentrated liquid used in the above-mentioned processing system 1, and is equipped with a concentration line 132 for sending concentrated liquid to the internal space 131 of the concentration bag, a recirculation line 133 for removing the liquid in the concentration bag 13 for re-concentration, and a partition 134 that can prevent liquid of a higher concentration than the concentrated liquid sent from the concentration line 132 from moving to the recirculation line 133.

[0049] The body fluid sent from the concentration line 132 to the internal space 131 can create a concentration gradient in the internal space 131, with the upper layer having a relatively low concentration and the lower layer having a relatively high concentration. Therefore, with the above configuration, the liquid with a relatively low concentration will have priority over the liquid with a relatively high concentration and will flow over the partition 134 into the recirculation line 133. Therefore, by being able to send a relatively dilute body fluid, clogging of the concentrator can be suppressed, and the recirculation process can be performed stably.

[0050] It can also be said that the concentration bag 13 of the second embodiment includes a partition 134 that at least partially separates the concentration line 132 and the recirculation line 133 from each other.

[0051] 2D and 2E show schematic configuration diagrams of the first embodiment of the concentrate bag 13. As shown in FIG. 2D, a partition 134 may be provided upward from the bottom side 13a of the concentrate bag 13 so as to at least partially separate the concentrate line 132 and the recirculation line 133.

[0052] The partition 134 is not particularly limited as long as it is provided between the concentration line 132 and the recirculation line 133. For example, it may be any partition that blocks the movement of the concentrated liquid sent from the concentration line 132 toward the recirculation line 133, and the length, angle, and the like are not limited to the example shown in FIG. 2D. As shown in FIG. 2D, the concentration line 132 and the recirculation line 133 may be provided on the bottom side 13a of the concentration bag 13, or on the side (side surface) 13c of the concentration bag 13.

[0053] 2E, the concentration line 132 and the recirculation line 133 may be provided at the top 13b and bottom 13a of the concentration bag 13, respectively. In this case, a partition 134 may be provided upward from the side 13c of the bag so as to at least partially separate the concentration line 132 from the recirculation line 131. This may allow the concentrated liquid delivered from the concentration line 132 to be stored in the space 131c formed by the partition 134 and the top and / or side of the concentration bag 13. The angle on the top 13b side formed by the partition 134 and the side 13c on which the partition 134 is provided may be any angle that allows the concentrated liquid delivered from the concentration line 132 to be stored, and may be, for example, less than 90°.

[0054] The height and length of the partition 134, and the angle between the partition 134 and the bottom side 13a or the side 13c may be variable. For example, the partition 134 may be formed by engaging a zipper having a pair of interlocking engaging portions provided on the inner space 131 side of the concentration bag 13, and the height and length of the partition 134 may be adjustable by changing the length of the zipper engagement.

[0055] 2F, the partition 134 includes a first portion 134a and a second portion 134b located above the first portion 134a, and the water permeability of the first portion 134a may be lower than that of the second portion 134b. This allows moisture to move from the second portion 134b of the partition 134 toward the recirculation line 133.

[0056] 1.3.Setting the concentrate bag The concentrated bag set of this embodiment is a concentrated bag set that includes a concentrated bag 13 for collecting concentrated liquid used in a processing system that processes blood and / or body cavity fluid, and a jig that clamps the concentrated bag 13 from the outside.

[0057] Concentration bag 13 includes a concentration line 132 for sending concentrated liquid into internal space 131 of the concentration bag, and a recirculation line 133 for removing the liquid from concentration bag 13 for reconcentration. Jig 135 sandwiches concentration bag 13 from the outside, thereby forming a partition that at least partially separates first space 131a on the concentration line 132 side from second space 131b on the recirculation line 133 side.

[0058] 2G, the concentration bag 13 may have a mark 137 that indicates the position where the bag is clamped by the jig 135. The shape and form of the mark are not particularly limited.

[0059] 3 is a schematic diagram showing a concentrate bag placed in the treatment device of this embodiment. As shown in FIG. 3, jig 135 may be at least a part of a holder for the concentrate bag provided in a treatment system for treating blood and / or body cavity fluid. For example, by setting the concentrate bag in the holder of the housing of the treatment system, the holder may sandwich concentrate bag 13 from the outside, and this portion may form a partition that at least partially separates first space 131a on the concentration line 132 side from second space 131b on the recirculation line 133 side.

[0060] 2. Processing System The processing system 1 of this embodiment includes a filtration and concentration unit 2 that performs a filtration and concentration step, a re-concentration unit 3 that performs a re-concentration step, and a control unit 5. FIG. 1 is an explanatory diagram showing an outline of the configuration of the processing system of this embodiment. The processing system 1 of this embodiment is a processing system that processes blood and / or body cavity fluid. Note that the configuration of the processing system 1 is not limited to that shown in FIG. 1, and may be any system that is capable of performing filtration and concentration.

[0061] The filtering and concentrating unit 2 filters and concentrates the blood and / or body cavity fluid in the processing bag 10 and stores it in a concentration bag 13. The filtering and concentrating unit 2 is composed of, for example, the processing bag 10, a filter 11, a concentrator 12, a concentration bag 13, a first liquid transfer line 14, a second liquid transfer line 15, a third liquid transfer line 16, a fourth liquid transfer line 17, a sixth liquid transfer line 19, valves 80 and 100, a first liquid transfer unit 81, and a second liquid transfer unit 90.

[0062] The re-concentration unit 3 re-concentrates the liquid stored in the concentration bag 13 by passing it through the concentrator 12. The re-concentration unit 3 is composed of, for example, the concentrator 12, the concentration bag 13, a fifth liquid feed line 18, a second liquid feed line 15, a third liquid feed line 16, a fourth liquid feed line 17, valves 100 and 110, a first liquid feed unit 81, a second liquid feed unit 90, etc.

[0063] Here, the fifth liquid supply line 18 and the second liquid supply line 15 constitute a first flow path 61 that connects the recirculation line 133 of the concentration bag 13 to the concentrator 12. Furthermore, the third liquid supply line 16 constitutes a second flow path 62. The first flow path 61 may have a first liquid supply unit 81 that discharges liquid from the concentration bag 13 via the recirculation line 133 and the first flow path 61. Furthermore, the second flow path 62 may have a second liquid supply unit 90 that supplies the liquid discharged from the concentrator 12 to the concentration bag 13 via the concentration line 132 and the second flow path 62.

[0064] The control unit 5 is, for example, a computer having a CPU, memory, etc. The control unit 5 can execute a predetermined ascites treatment by controlling the operation of each device, such as the first fluid supply unit 81, the second fluid supply unit 90, the valves 80, 100, 110, 122, the pressure measuring devices 50, 71, 83, 101, and the weight scale 21. The control unit 5 can realize the ascites treatment by, for example, executing a program stored in the memory with the CPU.

[0065] For example, by executing a predetermined program stored in memory, the control unit 5 causes the filtration and concentration unit 2 to perform a filtration and concentration step, and when the amount of concentrated ascites fluid in the concentration bag 13 reaches a first predetermined amount during the filtration and concentration step, the control unit 5 subsequently causes the re-concentration unit 3 to perform a re-concentration step, and when the pressure corresponding to the transmembrane pressure difference P6 of the concentrator 12 reaches a predetermined threshold during the re-concentration step, the control unit 5 returns to the filtration and concentration step by the filtration and concentration unit 2. The control unit 5 also repeatedly performs the filtration and concentration step and the re-concentration step, and finally performs the filtration and concentration step.

[0066] For example, the control unit 5 may control the driving or stopping of the first liquid delivery unit 81 depending on the amount of liquid delivered by the second liquid delivery unit 90. Specifically, when the control unit 5 determines that the amount of liquid delivered by the second liquid delivery unit 90 has reached a predetermined amount, the control unit 5 may drive the first liquid delivery unit 81 and execute the re-concentration step. Furthermore, for example, when the control unit 5 determines that the amount of liquid delivered by the second liquid delivery unit 90 during the execution of the re-concentration step has reached a predetermined amount, the control unit 5 may stop the first liquid delivery unit 81 and end the re-concentration step.

[0067] Furthermore, the control unit 5 may control the driving or stopping of the first liquid delivery unit 81 depending on the weight of the concentration bag 13. Specifically, when the control unit 5 determines that the weight of the concentration bag 13 has reached a predetermined value, the control unit 5 may drive the first liquid delivery unit 81 and execute the re-concentration process. Furthermore, for example, when the control unit 5 determines that the amount of decrease or change in the weight of the concentration bag 13 during the execution of the re-concentration process has reached a predetermined value, the control unit 5 may stop the first liquid delivery unit 81 and end the re-concentration process.

[0068] Furthermore, when the concentration bag 13 has a partition, either alone or by a jig, the control unit 5 may control the drive or stop of the first liquid delivery unit 81 depending on the height and length of the partition 134 and the angle between the partition 134 and the bottom side 13a or the side 13c. Specifically, the control unit 5 may control the drive or stop of the first liquid delivery unit 81 depending on the size of the space capable of storing the concentrated liquid, which is determined based on the height and length of the partition 134 and the angle between the partition 134 and the bottom side 13a or the side 13c. When the control unit 5 determines that the amount of liquid delivered by the second liquid delivery unit 90 has reached a predetermined amount determined based on the size of the space capable of storing the concentrated liquid, the control unit 5 may drive the first liquid delivery unit 81 and execute the re-concentration process. Furthermore, for example, when the control unit 5 determines that the amount of liquid delivered by the second liquid delivery unit 90 during the re-concentration process has reached a predetermined amount, the control unit 5 may stop the first liquid delivery unit 81 and terminate the re-concentration process. The predetermined amount may be, for example, a value exceeding the size of the space capable of storing the concentrated liquid. Furthermore, when the control unit 5 determines that the weight of the concentration bag 13 has reached a specified value determined according to the size of the space capable of storing the concentrated liquid, the control unit 5 may drive the first liquid delivery unit 81 to execute the re-concentration process. Furthermore, for example, when the control unit 5 determines that the amount of decrease or change in the weight of the concentration bag 13 during the execution of the re-concentration process has reached a predetermined value, the control unit 5 may stop the first liquid delivery unit 81 and end the re-concentration process.

[0069] The recirculation line 133 may have a detection unit that detects the presence or absence of liquid in the recirculation line 133, and the driving or stopping of the first liquid delivery unit 81 may be controlled according to the detection result of the detection unit. Specifically, when the detection unit 136 detects the presence of liquid, the first liquid delivery unit 81 may be driven to execute the re-concentration step, and when the detection unit 136 does not detect the presence of liquid, the first liquid delivery unit 81 may be stopped to end the re-concentration step.

[0070] The control unit 5 may control a reverse operation in which the liquid contained in the concentration bag is discharged from the concentration line 132 to the recirculation line 133 via the first flow path and the second flow path 62. Positioning the port 133a of the recirculation line 133 above the port 132a of the concentration line 132 facilitates reconcentration of the relatively dilute liquid in the concentration bag 13. However, some liquid, such as the liquid located below the port 133a of the recirculation line 133, cannot be concentrated in the concentration bag 13. Furthermore, even if the relatively dilute liquid in the concentration bag 13 is reconcentrated, clogging may occur on the inlet side of the concentrator 12, making reconcentration impossible. To solve this problem, it is possible to reverse the roles of the concentration line 132 and the recirculation line 133. That is, the control unit 5 may perform a reverse operation in which the liquid is discharged from the concentration bag 13 via the concentration line 132 and the second flow path 62. Specifically, the control unit 5 may drive the second liquid delivery unit 90 in a direction opposite to that shown in FIG. 1 to discharge the liquid from the concentration bag 13 via the concentration line 132. The discharged liquid is delivered to the concentration bag 13 via the concentrator 12, the first flow path 61, the second flow path 62, and the recirculation line 133. That is, the control unit 5 drives the first liquid delivery unit 81 in a direction opposite to that shown in FIG. 1, closes valves 80 and 122, and opens valve 110. These controls enable the concentrated liquid to be reconcentrated even when the liquid level is below the opening 133a of the recirculation line 133. In this case, because the concentrated liquid is delivered at a higher concentration than the liquid supplied from the recirculation line 133, the control unit 5 may drive the second liquid delivery unit 90 at a higher speed than when processing the liquid supplied from the recirculation line 133. Furthermore, when the control unit 5 detects a pressure increase on the liquid inlet side of the concentrator 12, it can also remove clogging on the liquid inlet side of the concentrator 12 by performing the reverse operation described above. In addition, if the pressure rise is not relieved even after reverse operation, it can be determined that a blockage has occurred on the side of the hollow fibers of the concentrator 12, and this information can be used to take measures to continue the treatment thereafter. Note that recirculation from the recirculation line 133 and recirculation by reverse operation from the concentration line 132 may be performed alternately.This allows efficient recirculation while suppressing clogging on the liquid inlet side of the concentrator 12.

[0071] The processing system 1 may also include the concentration bag 13 of this embodiment, or a set of the concentration bag 13 of this embodiment and the jig 135. The concentration bag of this embodiment is a concentration bag for collecting a concentrated liquid used in this processing system. [Explanation of symbols]

[0072] 1... treatment system, 2... filtration / concentration section, 3... reconcentration section, 5... control section, 10... treatment bag, 11... filter, 11a... liquid passage port, 11b... liquid passage port, 11c... liquid passage port, 11d... liquid passage port, 12... concentrator, 12a... liquid passage port, 12b... liquid passage port, 12c... liquid passage port, 12d... liquid passage port, 13... concentration bag, 13a... bottom, 13a1... inclined section , 13a2...non-inclined portion, 13b...upper portion, 13c...side portion, 14...first liquid transfer line, 15...second liquid transfer line, 16...third liquid transfer line, 17...fourth liquid transfer line, 18...fifth liquid transfer line, 19...sixth liquid transfer line, 20...supply means, 21...weighing scale, 30...filtration membrane, 30a...space, 30b...space, 40...concentration membrane, 40a ...space, 40b...space, 50...first pressure measuring device, 61...first flow path, 62...second flow path, 70...gas introduction line, 71...second pressure measuring device, 80...valve, 81...first liquid delivery section, 82...drip chamber, 83...third pressure measuring device, 90...second liquid delivery section, 100...valve, 101...fourth pressure measuring device, 110...valve, 120...storage section, 121...supply line, 122...valve, 131...internal space, 131a...first space, 131b...second space, 131c...space, 132...concentration line, 132a...port, 133...recirculation line, 133a...port, 134a...first part, 134b...second part, 135...jig, 136...detection section, 137...mark.

Claims

1. A concentrate bag for collecting a concentrate used in a treatment system for treating blood and / or body cavity fluid, comprising: a concentrate line for delivering concentrated liquid into the concentrate bag; a recirculation line for removing liquid from the concentrate bag for reconcentration; The mouth of the recirculation line is configured at a higher position than the mouth of the concentrate line. Concentrate bag.

2. the recirculation line port and the concentrate line port are provided at the bottom of the concentrate bag; The bottom of the concentrate bag is inclined, The recirculation line opening is positioned higher than the concentration line opening at the bottom of the concentration bag. The concentrate bag of claim 1.

3. The recirculation line is a tube inserted into the concentrate bag from below, and the mouth of the recirculation line is located inside the concentrate bag. The concentrate bag of claim 1.

4. The recirculation line is provided to the side or above the concentrate bag. The concentrate bag of claim 1.

5. A concentrate bag for collecting a concentrate used in a treatment system for treating blood and / or body cavity fluid, comprising: a concentrate line for delivering the concentrated liquid into the concentrate bag; a recirculation line for removing the liquid in the concentrate bag for reconcentration; a partition that can prevent a liquid having a higher concentration than the liquid sent from the concentration line from moving to the recirculation line; Concentrate bag.

6. The partition extends upward from the bottom of the bag to at least partially separate the concentrate line from the recirculation line. The concentrate bag of claim 5.

7. The partition is provided upward from the side of the concentrate bag so as to at least partially separate the concentrate line from the recirculation line. The concentrate bag of claim 5.

8. The concentrated liquid delivered from the concentration line can be stored in a space formed by the partition and the upper and / or side of the concentration bag. The concentrate bag of claim 5.

9. The height, length, and angle of the partition with the base or side are variable. The concentrate bag of claim 5.

10. The partition includes a first portion and a second portion located above the first portion, and the first portion has a lower water permeability than the second portion. The concentrate bag of claim 5.

11. A concentrate bag for collecting a concentrate used in a treatment system for treating blood and / or body cavity fluid, comprising: a concentrate line for delivering concentrated liquid into the concentrate bag; a recirculation line for removing liquid from the concentrate bag for reconcentration; and a partition at least partially separating the concentrate line from the recirculation line. Concentrate bag.

12. A set of concentrate bags including a concentrate bag for collecting a concentrate used in a treatment system for treating blood and / or body cavity fluid, and a jig for clamping the concentrate bag from the outside, The concentrate bag includes a concentrate line for delivering concentrated liquid into the concentrate bag and a recirculation line for removing liquid from the concentrate bag for reconcentration; The jig sandwiches the concentration bag from the outside to form a partition that at least partially separates a first space on the concentration line side from a second space on the recirculation line side. A set of concentrate bags.

13. The concentration bag has a mark indicating the position where it is clamped by the jig.

13. The set of concentrate bags of claim 12.

14. The jig is at least a part of a holding portion of the concentrate bag included in a processing system for processing blood and / or body cavity fluid.

13. The set of concentrate bags of claim 12.

15. 1. A treatment system for treating blood and / or body cavity fluids, comprising: A set of a concentrate bag according to any one of claims 1 to 11 or a concentrate bag according to any one of claims 12 to 14; A concentrator; a first flow path connecting the recirculation line of the concentrate bag and the concentrator; a second flow path connecting the concentrator and a concentration line of the concentration bag; a first liquid delivery unit provided in the first flow path and configured to discharge the liquid from the concentrate bag via the recirculation line and the first flow path; a second liquid delivery unit provided in the second flow path and configured to supply the liquid to the concentration bag via the concentration line and the second flow path; a control unit that controls the first liquid delivery unit and the second liquid delivery unit, Processing system.

16. the control unit controls driving or stopping of the first liquid delivery unit depending on the amount of liquid delivered by the second liquid delivery unit. The processing system of claim 15.

17. The control unit controls driving or stopping of the first liquid delivery unit depending on the weight of the concentrated bag. The processing system of claim 15.

18. When the concentration bag has a partition, either alone or by a jig, the control unit controls driving or stopping of the first liquid delivery unit depending on the height and length of the partition and the angle formed between the partition and the bottom or side. The processing system of claim 15.

19. the recirculation line has a detector that detects the presence or absence of liquid in the recirculation line; controlling the driving or stopping of the first liquid delivery unit according to the detection result of the detection unit; The processing system of claim 15.

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