Biological state estimation system, biological state estimation method, program, and recording medium

Abstract

To provide a new system that allows, for example, a subject or a person acting on behalf of the subject (for example, a family member or a doctor) to easily and quickly obtain typing results, biological state information based on those results, and optionally, corresponding information.SOLUTION: A biological state estimation system of the present invention includes a terminal and a server, both of which are connectable via a communication network. The terminal includes a biomolecule information acquisition unit and an output unit. The biomolecule information acquisition unit analyzes a biological sample from a subject to acquire biomolecule information, and the output unit outputs the biomolecule information to the server. The server includes a storage unit, a biological state estimation unit, and an output unit. The storage unit has an estimation information set in which the biomolecule information and biological state information are associated with each other. The biological state estimation unit estimates the biological state of the subject from the biomolecule information of the subject received from the terminal and the estimation information set. The output unit outputs estimated information on the biological state.SELECTED DRAWING: Figure 1

Description

[Technical Field]

[0001] The present invention relates to a biological state estimation system, a biological state estimation method, a program, and a recording medium. [Background technology]

[0002] From the perspective of medical care and health promotion, nucleic acid typing and protein marker detection have become common testing methods in recent years. When a subject self-collects a sample using a commercially available collection kit, the subject sends the sample to a testing center, which then returns the test results and biometric information derived from the test results to the subject as a report. The same process applies when a sample is collected at a clinic: the clinic sends the sample to the testing center, which then returns the test results and biometric information derived from the test results to the clinic as a report. Furthermore, recent advances in genomic medicine have revealed that human genetic polymorphisms determine phenotypic traits such as disease, disease susceptibility, and constitution, and information on which genetic polymorphisms determine phenotypic traits is rapidly accumulating. Demand for genotyping is expected to increase in the future. Traditionally, these methods involved sending the subject's sample to a testing center, where the results of analysis were reported to the subject. Summary of the Invention [Problem to be solved by the invention]

[0003] However, transporting specimens collected from living organisms is time-consuming and costly, as some specimens require transportation at refrigerated or room temperature. Furthermore, depending on the test item, if the subject does not receive the results as soon as possible, it may interfere with their daily lives or even be life-threatening.

[0004] In recent years, on-site testing has been developed, allowing subjects to collect samples and obtain test results on the spot. In particular, point-of-care testing (POCT) devices have been developed, allowing test results to be obtained in a short time after the sample is submitted to the testing device, making on-site testing very common. Furthermore, the devices are portable and pocket-sized, allowing self-collected samples to be tested anytime, anywhere.

[0005] Therefore, the present invention aims to provide a new system that enables a subject or a person acting on behalf of the subject (e.g., a family member, a doctor, a medical professional, etc.) to easily and quickly report information on the biological condition (including, for example, instructions from a doctor or a medical professional) to the subject using on-site testing that can eliminate the influence on test results of sample denaturation that occurs during sample transportation. [Means for solving the problem]

[0006] In order to achieve the above object, the biological state estimation system of the present invention comprises: a terminal and a server, The terminal and the server are connectable via a communication network; The terminal A biomolecule information acquisition unit and an output unit are included, The biomolecule information acquisition unit Analyzing the subject's biological sample to obtain biomolecular information; The output unit outputting the biomolecule information to the server; The server a storage unit, a biological state estimation unit, and an output unit; The storage unit having an estimated information set; the estimated information set is an information set in which biomolecule information and biological state information are linked together, The biological state estimation unit Estimating a biological state of the subject from the biomolecule information of the subject from the terminal and the estimation information set; The output unit outputting the estimated information on the biological state; It is characterized by:

[0007] The biological state estimation method of the present invention comprises: Using the biological state estimation system of the present invention, The system includes a terminal and a server, the server has a storage unit, the storage unit has an estimated information set; the estimated information set is an information set in which biomolecule information and biological state information are linked together, a biomolecule information acquisition step, a first output step from the terminal, a biological state estimation step, and a second output step from the server, the biomolecule information acquisition step includes analyzing a biological sample from a subject by the terminal to acquire biomolecule information; the first output step outputs the biomolecule information from the terminal to the server; the biological state estimating step includes estimating, by the server, a biological state of the subject from the biomolecule information of the subject from the terminal and the estimation information set in the storage unit; The second output step outputs the estimated information on the biological state from the server. It is characterized by:

[0008] The program of the present invention is characterized by causing a computer to execute the biological state estimation method of the present invention.

[0009] The recording medium of the present invention is computer-readable and stores the program of the present invention. [Effects of the Invention]

[0010] According to the present invention, for example, a subject or his / her representative (hereinafter referred to as a user) introduces a biological sample of the subject into the terminal, which then analyzes the biological sample, and the server estimates the biological condition of the subject, which can then be output as an email to the user's smartphone, etc. [Brief explanation of the drawings]

[0011] [Figure 1] FIG. 1 is a block diagram showing an example of a biological state estimating system according to the first embodiment. [Figure 2] FIG. 2 is a schematic diagram illustrating an example of a storage unit according to the first embodiment. [Figure 3] FIG. 3 is a block diagram showing another example of the biological state estimating system according to the first embodiment. [Figure 4] FIG. 4 is a block diagram showing an example of a biological state estimating system according to the second embodiment. [Figure 5] FIG. 5 is a schematic diagram illustrating an example of a storage unit according to the second embodiment. [Figure 6] FIG. 6 is a block diagram showing another example of the biological state estimation system according to the fourth embodiment. [Figure 7] FIG. 7 is a block diagram showing another example of the biological state estimation system according to the fourth embodiment. [Figure 8] FIG. 8 is a block diagram showing another example of the hardware configuration of the biological state estimating system according to the first embodiment. DETAILED DESCRIPTION OF THE INVENTION

[0012] The present invention includes, for example, the following aspects. [1] A system including a terminal and a server, The terminal and the server are connectable via a communication network; The terminal A biomolecule information acquisition unit and an output unit are included, The biomolecule information acquisition unit Analyzing the subject's biological sample to obtain biomolecular information; The output unit outputting the biomolecule information to the server; The server a storage unit, a biological state estimation unit, and an output unit; The storage unit having an estimated information set; the estimated information set is an information set in which biomolecule information and biological state information are linked together, The biological state estimation unit Estimating a biological state of the subject from the biomolecule information of the subject from the terminal and the estimation information set; The output unit outputting the estimated information on the biological state; A biological state estimation system characterized by: [2] The biological state estimation system according to [1], wherein the biomolecule information is nucleic acid sequence information or nucleic acid modification information. [3] The biological state estimation system according to [1] or [2], wherein the biomolecule information is DNA or RNA sequence information, or DNA or RNA modification information. [4] A biological state estimation system according to any one of [1] to [3], wherein the biological state information is information on a disease, information on disease susceptibility, or information on a constitution. [5] The storage unit further includes correspondence information for improving the biological condition, and the biological condition information and the correspondence information are linked, Further, a correspondence selection unit is provided, The correspondence selection unit selecting correspondence information for the estimated biological state from the estimation information of the biological state estimated by the biological state estimation unit and the correspondence information in the storage unit; The output unit The biological state estimation system according to any one of [1] to [4], which outputs the biological state estimation information and the selected corresponding information. [6] The server is a first server; Further, a second server is included, the first server outputs the estimated information of the biological state to a second server; the second server has a storage unit, a correspondence selection unit, and an output unit; The storage unit The biological condition information includes correspondence information for improving the biological condition, and the biological condition information and the correspondence information are linked to each other; The correspondence selection unit selecting correspondence information for the estimated biological state from the estimation information of the biological state estimated by the biological state estimation unit and the correspondence information in the storage unit; The output unit The biological state estimation system according to any one of [1] to [5], which outputs the biological state estimation information and the selected correspondence information. [7] Using the biological state estimation system according to any one of [1] to [6], The system includes a terminal and a server, the server has a storage unit, the storage unit has an estimated information set; the estimated information set is an information set in which biomolecule information and biological state information are linked together, a biomolecule information acquisition step, a first output step from the terminal, a biological state estimation step, and a second output step from the server, the biomolecule information acquisition step includes analyzing a biological sample from a subject by the terminal to acquire biomolecule information; the first output step outputs the biomolecule information from the terminal to the server; the biological state estimating step includes estimating, by the server, a biological state of the subject from the biomolecule information of the subject from the terminal and the estimation information set in the storage unit; The second output step outputs the estimated information on the biological state from the server. A biological state estimation method comprising: [8] The biological state estimation method according to [7], wherein the biomolecule information is nucleic acid sequence information or nucleic acid modification information. [9] The biological state estimation method according to [7] or [8], wherein the biological state information is information on a disease, information on disease susceptibility, or information on a constitution.

[10] The storage unit further includes correspondence information for improving the biological condition, and the biological condition information and the correspondence information are linked together; Further, it has a correspondence selection step, the correspondence selection step includes selecting, by the server, correspondence information for the estimated biological state from the estimation information of the biological state and correspondence information in the storage unit; The biological state estimation method according to any one of [7] to [9], wherein the second output step outputs the biological state estimation information and the selected corresponding information from the server.

[11] A program that causes a computer to execute the biological state estimation method described in any one of [7] to

[10] .

[12] A computer-readable recording medium having the program described in

[11] recorded thereon.

[0013] Embodiments of the present invention will be described with reference to the drawings. The present invention is not limited to the following embodiments. In the following drawings, the same parts are designated by the same reference numerals. The descriptions of the embodiments can be used interchangeably unless otherwise specified. The configurations of the embodiments can be combined unless otherwise specified.

[0014] [Embodiment 1] An example of a biological state estimation system and a biological state estimation method according to the present invention will be described with reference to the drawings.

[0015] The biological state estimation system of this embodiment is a system in which a terminal and a server can be connected via a communication network. Fig. 1 is a block diagram showing an example of the configuration of the biological state estimation system of this embodiment. In the biological state estimation system 10, a terminal 2 and a server 3 can be connected via a communication network 4. The server 3 is also called a processing device.

[0016] (Terminal 2) The terminal 2 has a biomolecule information acquisition unit 23 and an output unit 24, and may further have, for example, a storage unit 21 and a biological sample introduction unit 25, and may further have an input unit and a display unit.

[0017] In the terminal 2, a biological sample from a subject is introduced into the biological sample introduction unit 25. The biomolecule information acquisition unit 23 analyzes the introduced biological sample and acquires biomolecule information. The output unit 24 outputs the acquired biomolecule information to the server 3 via the communication network 4.

[0018] As will be described later, the server 3 outputs information to the terminal 2 via the communication network 4, and therefore the terminal 2 can, for example, input information from the server 3 via the input unit and display it on the display unit. The terminal 2 can also store the information from the server 3 in the storage unit 21.

[0019] The type of biomolecule information obtained by the terminal 2 is not particularly limited. The biomolecule information may be information obtained from a biological sample, and examples thereof include information on nucleic acids such as genes, proteins, peptides, small molecules, etc. The nucleic acid information may be, for example, DNA information or RNA information. In the case of nucleic acid information, the type of information is not particularly limited, and examples thereof include nucleic acid sequence information, nucleic acid modification information, etc. The nucleic acid sequence information is not particularly limited, and examples thereof include the presence or absence or sequence of any gene, and the presence or type of any mutation in any gene (e.g., the presence or type of SNP, etc.). Furthermore, the nucleic acid modification information is, for example, information on methylation, hydroxymethylation, etc. The modification information can be used, for example, to determine from which organ the nucleic acid is derived.

[0020] The terminal 2 may be any device that can acquire information on a target biomolecule by introducing a biological sample, and may be selected depending on the type of biomolecule information. In this embodiment, the following description will be given taking the case where the biomolecule information is nucleic acid information as a specific example, but the biomolecule information is not limited to this.

[0021] Terminal 2 is, for example, a gene amplification device that obtains genetic information by gene amplification, and more specifically, a device that performs an amplification reaction of any gene on nucleic acids in the biological sample. Terminal 2 can obtain the desired nucleic acid information by, for example, setting an analytical cartridge containing the necessary amplification reagents depending on the type of nucleic acid information to be obtained. The type of amplification reaction is not particularly limited, and may be, for example, isothermal amplification, in which the reaction is carried out at a constant temperature, or non-isothermal amplification, in which the temperature is changed. Examples of the former include the SmartAmp (registered trademark) method, and examples of the latter include PCR.

[0022] As the terminal 2 for carrying out gene amplification, for example, a commercially available gene amplification device can be used, and as a specific example, GenPad (DNAFORM, Mirai Genomics) or the like can be used.

[0023] As described above, the terminal 2 may, for example, optionally include an input unit. The input unit further inputs output destination information to which the estimated information on the biological state estimated by the server 3 is to be output. The output destination information may, for example, be a user's email address. The user may, for example, be the subject or a person acting on behalf of the subject (e.g., a family member, a doctor, a medical professional, etc.). This output destination information may then be linked to the biomolecule information and output to the server 3 by the output unit 24.

[0024] The terminal 2 may, for example, input information about the biological sample using the input unit and store it in the memory unit 21, and may link this information with the biomolecule information and output it to the server 3 using the output unit 24. Examples of information about the biological sample include the type of organism, age, sex, and medical history; and the type of sample. The type of organism is, for example, the type of subject, and may be a human (subject) or a non-human animal (subject animal). The type of sample is not particularly limited and may be, for example, blood, urine, oral mucosa, nasal mucosa, nasal secretion, etc.

[0025] The terminal 2 may be controlled by the terminal 2 itself, or by an external device (for example, a mobile phone such as a smartphone, a tablet, a PC, or a server).

[0026] (Server 3) The server 3 includes a storage unit 31, a biological state estimation unit 33, and an output unit 34, and may further include an input unit, for example.

[0027] The storage unit 31 has an estimated information set. The estimated information set is an information set in which biomolecule information and biological state information are linked. As shown in FIG. 2, for example, a gene sequence or mutation, which is biomolecule information 51, is linked to the type of biological state information 52. In the present invention, examples of the biological state information include disease information, disease susceptibility information, and constitution information. Furthermore, the estimated information set may link the biomolecule information and the biological state information for, for example, one or a combination of two or more of the type of organism, age, sex, and medical history.

[0028] The biological state estimation unit 33 estimates the biological state of the subject from the biomolecular information of the subject from the terminal 2 and the estimation information set. For example, if the biomolecular information of the subject is mutation 1-1 of gene 1, as shown in Figure 2, since the mutation 1-1 is linked to biological state information A, the biological state estimation unit 33 can estimate that the biological state of the subject is the biological state of A.

[0029] The output unit 34 outputs the estimated information on the biological state of the subject estimated by the biological state estimation unit 33 to the outside via the communication network 4. The output destination is not particularly limited, and may be, for example, an external device. The external device may be, for example, a terminal 2 having a biomolecule information acquisition unit 23, or the user's device. The user's device may be, for example, a mobile phone such as a smartphone, a tablet, a PC, a server, an electronic medical record, or the like.

[0030] (Biological condition estimation method) As described above, the biological state estimation method of the present invention can be performed using the biological state estimation system of the present invention, and includes a biomolecule information acquisition step, a first output step from the terminal, a biological state estimation step, and a second output step from the server. An example of a method using the biological state estimation system of the present embodiment 1 will be described below.

[0031] The biomolecule information acquisition step is a step of acquiring biomolecule information by analyzing a biological sample from a subject using the terminal 2. Specifically, this step involves introducing the biological sample into the biological sample introduction unit 25 of the terminal 2, analyzing the biological sample using the biomolecule information acquisition unit 23, and acquiring biomolecule information about the biological sample. As described above, the biomolecule information to be acquired can be set arbitrarily depending on the purpose, for example.

[0032] The first output step is a step of outputting the biomolecule information from the terminal 2 to the server 3. Specifically, in this step, the biomolecule information is output from the output unit 24 of the terminal 2 to the server 3 via the communication network 4.

[0033] The biological state estimation step is a step of estimating the biological state of the subject by the server 3 from the biomolecule information of the subject from the terminal 2 and the estimation information set in the storage unit 31. This step can be performed by the biological state estimation unit 33 of the server 3.

[0034] The second output step is a step of outputting the estimated information of the biological state from the server 3 to the outside. Specifically, in this step, the estimated information is output from the output unit 34 of the server 3 via the communication network 4. The output destination is not particularly limited, and may be, for example, the external device described above.

[0035] The biological state estimating method may further include a display step in which, when the external device has a display unit, the server 3 outputs the estimated information to the external device, and then the display step displays the estimated information on the display unit of the external device.

[0036] The biological state estimation system and biological state estimation method of the present invention make the following possible. Specifically, when a user carrying a terminal 2 introduces a biological sample from a subject into the terminal 2, the biological state estimation system 10 analyzes the biological sample using the terminal 2, transmits the analysis results (i.e., biomolecular information about the biological sample) to the server 3, estimates the biological state of the subject, and outputs the estimated information to an external device (e.g., the aforementioned terminal 2, a mobile phone, a PC, the user's server, etc.). In other words, a user can start analyzing the biomolecular information by simply introducing the subject's biological sample into the terminal 2 on-site, and obtain the estimated results of the subject's biological state on the user's external device. Therefore, for example, if the terminal 2 is installed in a company, government office, school, etc., as shown in FIG. 3 , analysis of the biological samples of multiple subjects can be easily initiated by simply introducing the biological samples of staff or students into the installed terminal 2, and further, estimated results regarding the biological state can be easily obtained. Furthermore, if terminal 2 is installed in a store such as a pharmacy or convenience store, customers can simply introduce the subject's biological sample to begin analysis of the biological sample, and can easily obtain estimated results.

[0037] The terminal of the present invention is a terminal used in the biological state estimation system of the present invention, and the description of the terminal in the biological state estimation system can be used. The server of the present invention is a server used in the biological state estimation system of the present invention, and the description of the server in the biological state estimation system can be used.

[0038] [Embodiment 2] As shown in FIG. 4, the biological state estimating system 11 of this embodiment is configured such that the server 3 further includes a response selecting unit .

[0039] In this case, the storage unit 31 further includes correspondence information for improving the biological condition. As shown in Fig. 5, for example, types of biological condition information 52 are linked to corresponding correspondence information 53. The correspondence information 53 is also called instructions, and examples thereof include cautions, suggestions for supplements, suggestions for improving lifestyle habits, suggestions for exercise, and suggestions for visiting a hospital.

[0040] The correspondence selection unit 35 of the server 3 selects correspondence information for the estimated biological state from the estimation information of the biological state estimated by the biological state estimation unit 33 and the correspondence information in the storage unit 31. Then, the output unit 34 of the server 3 outputs the estimation information of the biological state and the selected correspondence information to the outside via the communication network 4.

[0041] The user can receive the estimated information on the biological condition of the subject together with corresponding information from the external device, for example, so that the user can not only obtain the estimated information on the biological condition but also obtain corresponding measures at the same time.

[0042] [Embodiment 3] The biological state estimation system and biological state estimation method of the present invention can be used, for example, to prevent heatstroke.

[0043] CPT2 (carnitine palmitoyltransferase) is one of the enzymes involved in the energy metabolism of fatty acids. When the CPT2 gene is mutated, the enzyme's heat resistance decreases. As a result, when body temperature rises, the degree of decrease in enzyme activity increases, reducing the ability to use fatty acids as an energy source. This hinders the production of ATP, increasing the risk of multiple organ failure. As a result, it has been reported that heatstroke, which causes an increase in body temperature, is more likely to become severe, and that fever caused by influenza infection increases the risk of influenza encephalopathy.

[0044] Therefore, in the storage unit 31 of the server 3, information on mutations in the CPT2 gene is stored as biomolecule information 51, disease susceptibility (constitution) caused by ATP production inhibition is stored as biological condition information 52, and suggestions such as avoiding direct sunlight, wearing a parasol or hat, replenishing salt and / or sugar, and taking breaks are stored as response information 53. Furthermore, an analytical cartridge for typing the CPT2 mutant gene is set in the terminal 2, for example. Thus, by simply introducing a biological sample from the subject into the terminal 2, the user can easily receive information on disease susceptibility (e.g., whether or not there is a risk of the disease becoming severe) that may arise from the mutation of the CPT2 gene and response information for prevention.

[0045] [Embodiment 4] The biological status system of this embodiment is exemplified as having a second server in addition to the server 3 (referred to as the first server) in the embodiment 1. Note that this embodiment is similar to the embodiments 1 and 2 unless otherwise specified.

[0046] A biological state estimating system 60 in FIG. 6 is a configuration in which the biological state estimating system 10 in FIG. 1 further includes a second server 7 in addition to the first server 3.

[0047] In the biological state estimation system 60, the first server 3 outputs the estimation information of the biological state to the second server 7.

[0048] The second server 7 has a storage unit, a correspondence selection unit, and an output unit. The storage unit contains correspondence information for improving the biological condition, and the biological condition information is linked to the correspondence information. The correspondence selection unit selects correspondence information for the estimated biological condition from the estimated information of the biological condition estimated by the biological condition estimation unit and the correspondence information in the storage unit. Then, the output unit outputs the selected correspondence information to the first server 3. Then, the output unit 34 of the first server 3 outputs the estimated information of the biological condition and the correspondence information to the outside.

[0049] A biological state estimating system 61 in FIG. 7 is a configuration in which the biological state estimating system 11 in FIG.

[0050] In the biological state estimation system 61, the first server 3 outputs the estimation information of the biological state to the second server 7.

[0051] The second server 7 has a storage unit, a correspondence selection unit, and an output unit. The storage unit contains correspondence information for improving the biological condition, and the biological condition information and the correspondence information are linked. The correspondence selection unit selects correspondence information for the estimated biological condition from the estimated information of the biological condition estimated by the biological condition estimation unit and the correspondence information in the storage unit. Then, the output unit outputs the selected correspondence information to the first server 3.

[0052] Then, the output unit 34 of the first server 3 outputs to the outside the correspondence information selected by the correspondence selection unit 35 of the first server 3, the correspondence information selected by the second server 7, and the estimated information of the biological state.

[0053] (Variation 1) In the biological state estimation system 60 or 61, the second server 7 may be, for example, configured within the system or configured outside the system. When the second server 7 is configured outside the system, it is sufficient that it can be connected to the first server 3 of the biological state estimation system 10 or 11 via a communication network. The communication network may be, for example, wireless or wired, and the examples described above can be used.

[0054] The second server 7 may be, for example, a database that stores biomolecular information, biological information related to the biomolecular information, and / or correspondence information for the biological information. The various types of information in the second server 7 may be stored in the second server 7 by experts (for example, medical institutions, doctors, or medical professionals). In this case, the correspondence information may include, for example, comments from experts.

[0055] (Variation 2) In the biological state estimation system 60 or 61, for example, the biomolecule information and / or estimated biological state information in the first server 3 may be presented to an expert (for example, a medical institution, a doctor, or a medical professional). Then, correspondence information and comments on the biological state of the subject by the expert may be input to the first server 3. Then, the correspondence information and comments may be output to a user from the first server 3 together with the estimated biological state information.

[0056] [Embodiment 5] 8 shows an example of a block diagram of the hardware configuration of the server 3 in the embodiment 1. The server 3 includes, for example, a CPU (Central Processing Unit) 301, a memory 302, a bus 303, an input unit 32, a display unit 304, a communication device 305, and a storage unit 31. The units of the server 3 are connected to each other via their respective interfaces (I / F) through the bus 303.

[0057] The CPU 301 is a processor that is responsible for overall control of the server 3, and is not limited to a CPU and may be another processor. In the server 3, the CPU 301 executes, for example, the program of the present invention and other programs, and also reads and writes various types of information.

[0058] The server 3 can be connected to a communication network 4 by, for example, a communication device 305 connected to a bus 303, and can also be connected to an external terminal 2 via the communication network 4. There are no particular limitations on the method of connection between the server 3 and the terminal 2, and a wireless connection is preferred, for example. There are no particular limitations on the communication network 4, and any known communication network can be used, such as the Internet, a telephone line, a LAN (Local Area Network), or WiFi (Wireless Fidelity).

[0059] The memory 302 includes, for example, a main memory, which is also referred to as a primary storage device. When the CPU 301 performs processing, the memory 302 reads, for example, a program 306 stored in an auxiliary storage device (described later), and the CPU 301 receives data from the memory 302 and executes the program 306. The program 306 is, for example, various operating programs such as the program of the present invention. The main memory is, for example, a RAM (random access memory). The memory 302 further includes, for example, a ROM (read only memory).

[0060] The storage unit 31 is also referred to as an auxiliary storage device, for example, in contrast to the main memory (primary storage device). The storage unit 31 includes, for example, a storage medium and a drive for reading and writing data from and to the storage medium. The storage medium is not particularly limited and may be internal or external, and examples thereof include a hard disk (HD), CD-ROM, CD-R, CD-RW, MO, DVD, flash memory, and memory card. The drive is not particularly limited. The storage unit 31 may also be exemplified by a hard disk drive (HDD) in which a storage medium and a drive are integrated. For example, the storage unit 31 stores the program 306, as described above. When the CPU 301 executes the program, the memory 302 reads the program 306 from the storage unit 31, as described above. The storage unit 31 may further include, for example, an estimated information set, etc., as described below.

[0061] The input unit 32 is, for example, an input device such as a touch panel, a keyboard, a scanner, etc. The display unit 304 is, for example, a display device, and specific examples include a display device such as an LED display or a liquid crystal display.

[0062] [Embodiment 6] The program of the present invention is a program that can execute the biological state estimation method of the present invention on a computer. Alternatively, the program of this embodiment may be recorded on, for example, a computer-readable recording medium. The recording medium is not particularly limited, and examples thereof include the storage media described above.

[0063] Although the present invention has been described above with reference to the embodiments, the present invention is not limited to the above-described embodiments. Various modifications that can be understood by those skilled in the art can be made to the configuration and details of the present invention within the scope of the present invention. [Industrial Applicability]

[0064] According to the present invention, for example, a subject or his / her representative (hereinafter referred to as a user) introduces a biological sample of the subject into the terminal, which then analyzes the biological sample, and the server estimates the biological condition of the subject, which can then be output as an email to the user's smartphone, etc.

Claims

1. a terminal and a server, The terminal and the server can be connected via a communication network; The terminal A biomolecule information acquisition unit and an output unit are included, The biomolecule information acquisition unit Analyzing the subject's biological sample to obtain biomolecular information; The output unit outputting the biomolecule information to the server; The server a storage unit, a biological state estimation unit, and an output unit; The storage unit having an estimated information set; the estimated information set is an information set in which biomolecule information and biological state information are linked together, The biological state estimation unit Estimating a biological state of the subject from the biomolecule information of the subject from the terminal and the estimation information set; The output unit outputting the estimated information on the biological state; A biological state estimation system characterized by:

2. The biological state estimation system according to claim 1 , wherein the biomolecule information is nucleic acid sequence information or nucleic acid modification information.

3. The biological state estimation system according to claim 1 , wherein the biomolecule information is DNA or RNA sequence information or DNA or RNA modification information.

4. The biological state estimation system according to claim 1 , wherein the biological state information is information on a disease, information on disease susceptibility, or information on a constitution.

5. the storage unit further includes correspondence information for improving the biological condition, and the biological condition information and the correspondence information are linked; Further, a correspondence selection unit is provided, The correspondence selection unit selecting correspondence information for the estimated biological state from the estimation information of the biological state estimated by the biological state estimation unit and the correspondence information in the storage unit; The output unit The biological state estimation system according to claim 1 , further comprising: a processor configured to output the biological state estimation information and the selected corresponding information.

6. the server is a first server; Further, a second server is included, the first server outputs the estimated information of the biological state to a second server; the second server has a storage unit, a response selection unit, and an output unit; The storage unit The biological condition information includes correspondence information for improving the biological condition, and the biological condition information and the correspondence information are linked to each other; The correspondence selection unit selecting correspondence information for the estimated biological state from the estimation information of the biological state estimated by the biological state estimation unit and the correspondence information in the storage unit; The output unit outputting the selected correspondence information to the first server; The output unit of the first server The biological state estimation system according to claim 1 , further comprising: a processor configured to output the biological state estimation information and the selected corresponding information.

7. Using the biological state estimation system according to any one of claims 1 to 6, the biological state estimating system includes a terminal and a server, the server has a storage unit, the storage unit has an estimated information set; the estimated information set is an information set in which biomolecule information and biological state information are linked together, a biomolecule information acquisition step, a first output step from the terminal, a biological state estimation step, and a second output step from the server, the biomolecule information acquisition step includes analyzing a biological sample from a subject by the terminal to acquire biomolecule information; the first output step outputs the biomolecule information from the terminal to the server; the biological state estimating step includes estimating, by the server, a biological state of the subject from the biomolecule information of the subject from the terminal and the estimation information set in the storage unit; The second output step outputs the estimated information on the biological state from the server. A biological state estimation method comprising:

8. The biological state estimation method according to claim 7 , wherein the biomolecule information is nucleic acid sequence information or nucleic acid modification information.

9. 9. The biological state estimation method according to claim 7, wherein the biological state information is information on a disease, information on disease susceptibility, or information on a constitution.

10. the storage unit further includes correspondence information for improving the biological condition, and the biological condition information and the correspondence information are linked; Further, it has a correspondence selection step, the correspondence selection step includes selecting, by the server, correspondence information for the estimated biological state from the estimation information of the biological state and correspondence information in the storage unit; The biological state estimation method according to claim 7 , wherein the second output step outputs the biological state estimation information and the selected corresponding information from the server.

11. A program causing a computer to execute the biological state estimation method according to any one of claims 7 to 10.

12. A computer-readable recording medium having the program according to claim 11 recorded thereon.

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